[ { "uniprot_canonical_ac": "Q9D806-1", "uniprot_id": [ { "id": "VSTM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D806", "type": "external" } ], "mass": 22564.0, "length": 199, "protein_name": "V-set and transmembrane domain-containing protein 5", "gene_name": "Vstm5", "organism": "Mouse", "refseq_name": "V-set and transmembrane domain-containing protein 5 precursor", "refseq_ac": [ { "id": "NP_081231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081231", "type": "external" } ], "gene_names_uniprotkb": "Vstm5", "gene_names_refseq": "2200002K05Rik; Vstm5", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 5", "protein_names_refseq": "V-set and transmembrane domain-containing protein 5 precursor; V-set and transmembrane domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:69137)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25826454;27683913;28746350;36308908", "class_list": "", "function": "Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain., [UniProtKB, PubMed]; Data indicate that four N-linked glycosylation sites (Asn43, Asn87, Asn101, and Asn108) are predicted to be located in the extracellular N-terminus of V-set and transmembrane domain-containing protein 5 (Vstm5), but their functional roles may not be identical. Publication Status: Online-Only, [RefSeq, PubMed]; In this study, we demonstrate for the first time that V-set and transmembrane domain-containing protein 5 (Vstm5), a putative cell adhesion membrane protein, modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics., [RefSeq, PubMed]; VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006955 immune response;GO:0046847 filopodium assembly;GO:0051260 protein homooligomerization;GO:0021517 ventral spinal cord development;GO:1904891 positive regulation of excitatory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D806-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "T1NXB5-1", "uniprot_id": [ { "id": "VSTM4_MOUSE", "url": "https://www.uniprot.org/uniprot/T1NXB5", "type": "external" } ], "mass": 35899.0, "length": 319, "protein_name": "V-set and transmembrane domain-containing protein 4", "gene_name": "Vstm4", "organism": "Mouse", "refseq_name": "V-set and transmembrane domain-containing protein 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_848906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848906", "type": "external" } ], "gene_names_uniprotkb": "Vstm4", "gene_names_refseq": "E130203B14Rik; Vstm4", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 4", "protein_names_refseq": "V-set and transmembrane domain-containing protein 4 isoform 1 precursor; V-set and transmembrane domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:320736)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22912796;25698653", "class_list": "", "function": "Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors., [UniProtKB, PubMed]; Vascular endothelial growth factor receptor 2 (VEGFR2) interacted with peptide Lv., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042311 vasodilation;GO:0043542 endothelial cell migration;GO:0061298 retina vasculature development in camera-type eye;GO:0002040 sprouting angiogenesis;GO:0001935 endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "T1NXB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E870-1", "uniprot_id": [ { "id": "TRIPC_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E870", "type": "external" } ], "mass": 224128.0, "length": 2025, "protein_name": "E3 ubiquitin-protein ligase TRIP12", "gene_name": "Trip12", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIP12", "refseq_ac": [ { "id": "NP_598736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598736", "type": "external" } ], "gene_names_uniprotkb": "Trip12", "gene_names_refseq": "1110036I07Rik; 6720416K24Rik; Gtl6; TRIP-12; Trip12", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIP12; 2.3.2.26; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; TRIP-12; Thyroid receptor-interacting protein 12", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIP12; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; gene trap locus 6; thyroid receptor interactor TRIP12; thyroid receptor-interacting protein 12", "tax_id": 10090, "disease": "Clark-Baraitser syndrome (Disease Ontology:DOID:0080234); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:14897); (R-MMU-983168)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;22028794;23806337;24788674;25428506;31219806;31616917;33080340;34428180;35820727;36210013;37863914", "class_list": "", "function": "Control of TGFbeta signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB]; Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY88;Q3UYT5;Q8BM59;Q8K051", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "G5E870-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01831-1", "uniprot_id": [ { "id": "THY1_MOUSE", "url": "https://www.uniprot.org/uniprot/P01831", "type": "external" } ], "mass": 18080.0, "length": 162, "protein_name": "Thy-1 membrane glycoprotein", "gene_name": "Thy1", "organism": "Mouse", "refseq_name": "thy-1 membrane glycoprotein preproprotein", "refseq_ac": [ { "id": "NP_033408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033408", "type": "external" } ], "gene_names_uniprotkb": "Thy1; Thy-1", "gene_names_refseq": "CD90; T25; Thy-1.2; Thy-1; Thy1.1; Thy1.2; Thy1", "protein_names_uniprotkb": "Thy-1 membrane glycoprotein; Thy-1 antigen", "protein_names_refseq": "thy-1 antigen; thy-1 membrane glycoprotein preproprotein; thy-1 membrane glycoprotein", "tax_id": 10090, "disease": "retinal ischemia (Disease Ontology:DOID:12510); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:21838); (R-MMU-163125)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;2582427;26192747;26495903;2857501;2866091;2868059;30779550;30899004;33300544;34428180;37828378;40885482;6177036", "class_list": "", "function": "May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 43, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0005096 GTPase activator activity;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0007267 cell-cell signaling;GO:0043547 positive regulation of GTPase activity;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 6.6, "record_id": "P01831-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1S4-1", "uniprot_id": [ { "id": "UNC5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1S4", "type": "external" } ], "mass": 98857.0, "length": 898, "protein_name": "Netrin receptor UNC5A", "gene_name": "Unc5a", "organism": "Mouse", "refseq_name": "netrin receptor UNC5A isoform 2 precursor", "refseq_ac": [ { "id": "NP_001298057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298057", "type": "external" } ], "gene_names_uniprotkb": "Unc5a; Kiaa1976; Unc5h1", "gene_names_refseq": "Unc5a; Unc5h1; mKIAA1976", "protein_names_uniprotkb": "Netrin receptor UNC5A; Protein unc-5 homolog 1; Protein unc-5 homolog A", "protein_names_refseq": "netrin receptor UNC5A isoform 2 precursor; netrin receptor UNC5A; protein unc-5 homolog 1; protein unc-5 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:107448); (R-MMU-373752)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12351186;12598531;21750661;22405201;22645316;25374360;28202721;33109704;34678516;36240740;40885482", "class_list": "", "function": "A mechanism for UNC5H1-mediated apoptosis that requires an interaction with the MAGE protein NRAGE, [RefSeq, PubMed]; GPC3-Unc5 receptor complex structure and role in cell migration., [RefSeq, PubMed]; Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions., [RefSeq, PubMed]; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand., [UniProtKB, UniProtKB]; Unc5h1 was cloned; its expression is restricted to the central nervous system in developing mouse, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 5, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 5, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 5, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 5, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEF7;Q80T71", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0006915 apoptotic process;GO:0007411 axon guidance;GO:0038007 netrin-activated signaling pathway;GO:0033564 anterior/posterior axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8K1S4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1110000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYV5-1", "uniprot_id": [ { "id": "TM135_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYV5", "type": "external" } ], "mass": 52364.0, "length": 458, "protein_name": "Transmembrane protein 135", "gene_name": "Tmem135", "organism": "Mouse", "refseq_name": "transmembrane protein 135 isoform a", "refseq_ac": [ { "id": "NP_082619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082619", "type": "external" } ], "gene_names_uniprotkb": "Tmem135", "gene_names_refseq": "2810439K08Rik; PMP52; Tmem135", "protein_names_uniprotkb": "Transmembrane protein 135; PMP52; Peroxisomal membrane protein 52", "protein_names_refseq": "peroxisomal membrane protein 52; transmembrane protein 135 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:72759)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "17768142;18299400;21151927;21750661;22872234;25428506;25605945;27802388;27863209;30084848;30779550;32515224;34428180;35031662;36599953;37773161;38154611", "class_list": "", "function": "A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (PubMed:27863209). May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L (PubMed:27863209). May be involved in peroxisome organization (By similarity)., [UniProtKB, UniProtKB, PubMed]; Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene., [RefSeq, PubMed]; TMEM135 integrates biological processes involving fat metabolism and energy expenditure in both the worm (invertebrates) and in mammalian organisms Publication Status: Online-Only, [RefSeq, PubMed]; TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics., [RefSeq, PubMed]; The authors observed localization of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as well as Tmem135 overexpressing cells, indicating that TMEM135 is involved in the regulation of mitochondrial dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSY5;Q8CCZ6;Q8CE78", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005811 lipid droplet", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0009409 response to cold;GO:0010628 positive regulation of gene expression;GO:0006633 fatty acid biosynthetic process;GO:0007031 peroxisome organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9CYV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62318-1", "uniprot_id": [ { "id": "TIF1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62318", "type": "external" } ], "mass": 88847.0, "length": 834, "protein_name": "Transcription intermediary factor 1-beta", "gene_name": "Trim28", "organism": "Mouse", "refseq_name": "transcription intermediary factor 1-beta", "refseq_ac": [ { "id": "NP_035718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035718", "type": "external" } ], "gene_names_uniprotkb": "Trim28; Kap1; Krip1; Tif1b", "gene_names_refseq": "KAP-1; KRIP-1; MommeD9; Tif1beta; Tif1b; Trim28", "protein_names_uniprotkb": "Transcription intermediary factor 1-beta; 2.3.2.27; E3 SUMO-protein ligase TRIM28; KRAB-A-interacting protein; KRIP-1; RING-type E3 ubiquitin transferase TIF1-beta; TIF1-beta; Tripartite motif-containing protein 28", "protein_names_refseq": "E3 SUMO-protein ligase TRIM28; KRAB-A-interacting protein; RING-type E3 ubiquitin transferase TIF1-beta; TIF1-beta; transcription intermediary factor 1-beta; transcriptional intermediary factor 1, beta; tripartite motif protein 28; tripartite motif-containing protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:21849); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 42, "publication_id_list": "10.1101/2023.09.13.557529;10330177;10562550;10940561;11154279;11331580;12154074;15345747;16452087;17242355;19131326;19144319;19321449;20164836;20508149;21183079;21518874;21540332;22110054;23806337;24413057;24463520;25247314;25605945;26495903;27123980;27658112;28011936;28648892;29187734;30017584;33657380;34428180;34887587;35820727;35984892;36852467;37507081;39627609;8978696;8986806;9742105", "class_list": "", "function": "E3 SUMO and ubiquitin ligase that plays a pivotal role in embryonic development, genomic imprinting, and maintenance of genomic stability through repression of repetitive and retroviral elements. Also involved in DNA repair, regulation of innate immunity or cellular energy homeostasis. Acts as a scaffold for assembling transcriptional repression complexes containing methyltransferases, histone deacetylases, and chromatin remodelers. Serves as a nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs), mediating gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1, which methylates histone H3 at Lys-9 (H3K9me), leading to heterochromatin formation (PubMed:20164836, PubMed:22110054, PubMed:25247314, PubMed:27658112). In collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836). Functions as a coactivator for CEBPB and NR3C1 (glucocorticoid receptor) in transcriptional activation of ORM1, and as a corepressor for ERBB4. Inhibits E2F1 activity by promoting E2F1-HDAC1 complex formation and preventing E2F1 acetylation. This contributes to CDKN1A/p21(CIP1) regulation and provides a partial backup to suppress E2F1-mediated apoptosis in the absence of RB1. Mediates the nuclear localization of several KRAB-ZFP transcription factors including KOX1, ZNF268, and ZNF300 among others. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs)(PubMed:20164836). Acts as a corepressor for ZFP568. Beyond its nuclear functions, acts as a positive regulator of type I interferon (IFN-I) signaling by promoting Lys-63-linked ubiquitination of TBK1, facilitating TBK1-IRF3 complex formation. Mediates TRAF6 SUMOylation to regulate its nucleo-cytoplasmic shuttling and modulate activation of the canonical NF-kappa-B signaling pathway. Facilitates SUMOylation of NLRP3, protecting it from 'Lys-48'-linked ubiquitination and proteasomal degradation and thereby enhancing inflammasome activation (By similarity)., [UniProtKB, UniProtKB]; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) (PubMed:20164836, PubMed:22110054, PubMed:25247314, PubMed:27658112). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:20164836). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Acts as a corepressor for ZFP568 (PubMed:22110054, PubMed:27658112)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70391;Q8C283;Q99PN4", "ec_number_list": [ { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0035851 Krueppel-associated box domain binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0043045 epigenetic programming of gene expression;GO:0044790 suppression of viral release by host;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q62318-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1C0-1", "uniprot_id": [ { "id": "TAF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1C0", "type": "external" } ], "mass": 39126.0, "length": 341, "protein_name": "Transcription initiation factor TFIID subunit 7", "gene_name": "Taf7", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 7", "refseq_ac": [ { "id": "NP_786964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786964", "type": "external" } ], "gene_names_uniprotkb": "Taf7; Taf2f", "gene_names_refseq": "55kDa; TAFII55; Taf2f; Taf7", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 7; RNA polymerase II TBP-associated factor subunit F; TAF(II)55; TAFII-55; TAFII55; Transcription initiation factor TFIID 55 kDa subunit", "protein_names_refseq": "RNA polymerase II TBP-associated factor subunit F; TAF(II)55; TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kDa; TAFII-55; TATA box binding protein (TBP) associated factor, RNA polymerase II, F, 55 kDa; transcription initiation factor TFIID 55 kDa subunit; transcription initiation factor TFIID subunit 7", "tax_id": 10090, "disease": "oligospermia (Disease Ontology:DOID:14228)", "pathway": " (mmu:24074); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10438527;17242355;21183079;34428180;36852467", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0046966 nuclear thyroid hormone receptor binding;GO:0061628 histone H3K27me3 reader activity;GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0071339 MLL1 complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R1C0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUK6-1", "uniprot_id": [ { "id": "TLR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUK6", "type": "external" } ], "mass": 95519.0, "length": 835, "protein_name": "Toll-like receptor 4", "gene_name": "Tlr4", "organism": "Mouse", "refseq_name": "toll-like receptor 4 precursor", "refseq_ac": [ { "id": "NP_067272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067272", "type": "external" } ], "gene_names_uniprotkb": "Tlr4; Lps", "gene_names_refseq": "Lps; Ly87; Ran/M1; Rasl2-8; Tlr4", "protein_names_uniprotkb": "Toll-like receptor 4", "protein_names_refseq": "Toll like receptor 4; lipopolysaccharide response; toll-like receptor 4 precursor", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); mastoiditis (Disease Ontology:DOID:0060322); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); meningococcal meningitis (Disease Ontology:DOID:0080176); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); urinary tract infection (Disease Ontology:DOID:0080784); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hymenolepiasis (Disease Ontology:DOID:10074); dry eye syndrome (Disease Ontology:DOID:10140); dermatomyositis (Disease Ontology:DOID:10223); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); mastitis (Disease Ontology:DOID:10690); primary open angle glaucoma (Disease Ontology:DOID:1070); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); cholesteatoma of middle ear (Disease Ontology:DOID:10964); pulpitis (Disease Ontology:DOID:11121); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); sciatic neuropathy (Disease Ontology:DOID:11446); suppurative otitis media (Disease Ontology:DOID:11506); hepatorenal syndrome (Disease Ontology:DOID:11823); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); carotid stenosis (Disease Ontology:DOID:13001); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); low tension glaucoma (Disease Ontology:DOID:13544); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); cystic echinococcosis (Disease Ontology:DOID:1495); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); glucose metabolism disease (Disease Ontology:DOID:4194); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); keratitis (Disease Ontology:DOID:4677); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); uric acid nephrolithiasis (Disease Ontology:DOID:580); myocardial infarction (Disease Ontology:DOID:5844); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); lung disease (Disease Ontology:DOID:850); collagen disease (Disease Ontology:DOID:854); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21898); (R-MMU-140534); (R-MMU-166016); (R-MMU-166166); (R-MMU-2562578); (R-MMU-5686938); (R-MMU-936964); (R-MMU-937041); (R-MMU-937072); (R-MMU-9707616); (R-MMU-975163); (R-MMU-9824878)", "pathway_count": 12, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;10087992;10548109;10952994;11104518;17478729;17538624;17803912;18780723;20037584;20133493;20865800;21750661;22078883;22496641;22532668;23812099;24380872;25116192;25302613;25428506;25736436;26095358;28098138;30084848;31226171;33912181;34428180;35896747;38378891;9851930;9989976", "class_list": "", "function": "(Microbial infection) Mediates activation of bone marrow-derived dendritic cells and macrophages, and production of pro-inflammatory cytokines, such as IL12 (IL12B/IL12A), triggered by Toxoplasma gondii micronemal protein 4 (MIC4) and micronemal protein 1 (MIC1) (PubMed:31226171). Mediates production of anti-inflammatory cytokine IL10 triggered by Toxoplasma gondii micronemal protein 4 (MIC4) and micronemal protein 1 (MIC1) in murine bone marrow-derived macrophages (PubMed:33912181)., [UniProtKB, PubMed, PubMed]; (Microbial infection) Required for the virulence of fungus C.neoformans var. grubii serotype A (strain KN99) CPL1 (PubMed:35896747). Independently of Ly96/Md2, activated by CPL1 which results in a type 2 inflammation response characterized by Arg1/arginase-1 induction in interstitial macrophages (PubMed:35896747)., [UniProtKB, PubMed]; Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS., [RefSeq, PubMed]; Global genetic deficiency of TLR4 also ameliorates renal inflammation, fibrosis and podocytopathy and could be important in diabetic nephropathy., [RefSeq, PubMed]; There is a pivotal contribution of TLR-4 to the pathologic tissue fibrosis of systemic sclerosis murine models., [RefSeq, PubMed]; These data establish that upon microbial detection, an upstream Pattern Recognition Receptor, CD14 controls the trafficking and signaling functions of a downstream Pattern Recognition Receptor, TLR4., [RefSeq, PubMed]; This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]., [RefSeq]; Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:20133493, PubMed:9851930, PubMed:9989976). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:9851930, PubMed:9989976). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:24380872). Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Using an in vitro system of lipopolysaccharide tolerance in murine macrophages, we show that TLR-induced genes fall into two categories on the basis of their functions and regulatory requirements Erratum:[Nature. 2008 Jan 3;451(7174):102], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 3, "disease_count": 91, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q9D691;Q9QZF5;Q9Z203", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0032700 negative regulation of interleukin-17 production;GO:0002246 wound healing involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q9QUK6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUN7-1", "uniprot_id": [ { "id": "TLR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUN7", "type": "external" } ], "mass": 89449.0, "length": 784, "protein_name": "Toll-like receptor 2", "gene_name": "Tlr2", "organism": "Mouse", "refseq_name": "toll-like receptor 2 precursor", "refseq_ac": [ { "id": "NP_036035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036035", "type": "external" } ], "gene_names_uniprotkb": "Tlr2", "gene_names_refseq": "Ly105; Tlr2", "protein_names_uniprotkb": "Toll-like receptor 2", "protein_names_refseq": "toll-like receptor 2 precursor", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); mastoiditis (Disease Ontology:DOID:0060322); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); meningococcal meningitis (Disease Ontology:DOID:0080176); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); urinary tract infection (Disease Ontology:DOID:0080784); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hymenolepiasis (Disease Ontology:DOID:10074); dry eye syndrome (Disease Ontology:DOID:10140); dermatomyositis (Disease Ontology:DOID:10223); leprosy (Disease Ontology:DOID:1024); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); anogenital venereal wart (Disease Ontology:DOID:11168); suppurative otitis media (Disease Ontology:DOID:11506); alveolar echinococcosis (Disease Ontology:DOID:12148); vitiligo (Disease Ontology:DOID:12306); carotid stenosis (Disease Ontology:DOID:13001); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); cystic echinococcosis (Disease Ontology:DOID:1495); alcohol use disorder (Disease Ontology:DOID:1574); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); skin papilloma (Disease Ontology:DOID:3178); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); glucose metabolism disease (Disease Ontology:DOID:4194); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); keratitis (Disease Ontology:DOID:4677); pancreatitis (Disease Ontology:DOID:4989); eye disease (Disease Ontology:DOID:5614); uric acid nephrolithiasis (Disease Ontology:DOID:580); primary immunodeficiency disease (Disease Ontology:DOID:612); acne (Disease Ontology:DOID:6543); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); gastroesophageal reflux disease (Disease Ontology:DOID:8534); collagen disease (Disease Ontology:DOID:854); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); bacterial pneumonia (Disease Ontology:DOID:874); seborrheic dermatitis (Disease Ontology:DOID:8741); molluscum contagiosum (Disease Ontology:DOID:8867); psoriasis (Disease Ontology:DOID:8893); cutaneous leishmaniasis (Disease Ontology:DOID:9111); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); keratoconjunctivitis (Disease Ontology:DOID:9368); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:24088); (R-MMU-1461957); (R-MMU-5686938); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10358136;10548109;10666214;10823826;11095740;15690042;17486091;17889651;18250455;18780723;19362712;19931471;21750661;22174456;22665377;25689444;26283364;27220037;27802388;27805901;31226171;31599954;34428180;35362478", "class_list": "", "function": "(Microbial infection) Mediates activation of bone marrow-derived dendritic cells and macrophages, and production of pro-inflammatory cytokines, such as IL12 (IL12B/IL12A), triggered by Toxoplasma gondii micronemal protein 4 (MIC4) and micronemal protein 1 (MIC1)., [UniProtKB, PubMed]; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 70, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U400;Q9DBC4", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0042497 triacyl lipopeptide binding;GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0032741 positive regulation of interleukin-18 production;GO:0032289 central nervous system myelin formation;GO:0032700 negative regulation of interleukin-17 production;GO:0002730 regulation of dendritic cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9QUN7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI84-1", "uniprot_id": [ { "id": "TGO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI84", "type": "external" } ], "mass": 213675.0, "length": 1930, "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "Mia3", "organism": "Mouse", "refseq_name": "transport and Golgi organization protein 1 homolog precursor", "refseq_ac": [ { "id": "NP_796363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796363", "type": "external" } ], "gene_names_uniprotkb": "Mia3; Kiaa0268; Tango", "gene_names_refseq": "9130229H14Rik; A930039G15Rik; B230399H06Rik; Gm1525; Mia3; TANGO1; Tango", "protein_names_uniprotkb": "Transport and Golgi organization protein 1 homolog; Melanoma inhibitory activity protein 3; TANGO1", "protein_names_refseq": "melanoma inhibitory activity 3; melanoma inhibitory activity protein 3; transport and Golgi organization protein 1 homolog precursor; transport and Golgi organization protein 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:338366); (R-MMU-381426); (R-MMU-5694530); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;15183315;17242355;19131326;19144319;21183079;21606205;21750661;22645316;24129315;25428506;30059200;30899004;31219806;32848054;34428180;34678516;34858331;36852467", "class_list": "", "function": "MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration. Publication Status: Online-Only, [RefSeq, PubMed]; Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms Erratum:[J Cell Biol. 2011 Jul 25;194(2):347], [RefSeq, PubMed]; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES., [UniProtKB, UniProtKB]; Revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A0JLX8;Q3UFI9;Q571D7;Q8BJE9;Q8BL31;Q8C5B9", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0007162 negative regulation of cell adhesion;GO:0015031 protein transport;GO:0042953 lipoprotein transport;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q8BI84-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHN8-1", "uniprot_id": [ { "id": "TIRR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHN8", "type": "external" } ], "mass": 23414.0, "length": 211, "protein_name": "Tudor-interacting repair regulator protein", "gene_name": "Nudt16l1", "organism": "Mouse", "refseq_name": "tudor-interacting repair regulator protein isoform 2", "refseq_ac": [ { "id": "NP_001303644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303644", "type": "external" } ], "gene_names_uniprotkb": "Nudt16l1; Sdos; Tirr", "gene_names_refseq": "1110001K21Rik; 5330437I08Rik; Nudt16l1; Sdos; syndesmos", "protein_names_uniprotkb": "Tudor-interacting repair regulator protein; NUDT16-like protein 1; Protein syndesmos", "protein_names_refseq": "NUDT16-like protein 1; nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1; protein syndesmos; tudor-interacting repair regulator protein isoform 2; tudor-interacting repair regulator protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66911)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11805099;21750661;26100207;26495903", "class_list": "", "function": "Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW47;Q8R039;Q8R3D9;Q9CR90;Q9D8M0", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAG4-1", "uniprot_id": [ { "id": "SMIP9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAG4", "type": "external" } ], "mass": 21041.0, "length": 180, "protein_name": "Protein SPMIP9", "gene_name": "Spmip9", "organism": "Mouse", "refseq_name": "protein SPMIP9 isoform 1", "refseq_ac": [ { "id": "NP_083101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083101", "type": "external" } ], "gene_names_uniprotkb": "Spmip9; Tex37; Tsc21", "gene_names_refseq": "1700011F03Rik; Spmip9; Tex37; Tsc21", "protein_names_uniprotkb": "Protein SPMIP9; Sperm microtubule inner protein 9; Testis-expressed sequence 37 protein; Testis-specific conserved protein of 21 kDa", "protein_names_refseq": "protein SPMIP9 isoform 1; protein SPMIP9; protein TSC21; testis expressed 37; testis-expressed sequence 37 protein; testis-specific conserved protein of 21 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:74221)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17091336;29563520;37295417", "class_list": "", "function": "Identification of a novel gene, Tsc21, exclusively expressed in testes., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagella axoneme., [UniProtKB, PubMed]; Study of the mouse Tex37 and Prss55 - genes evolutionarily conserved in eutherians (including human) found that these genes had a testis-enriched expression pattern in mice, but they are not individually essential for spermatogenesis, testis development and male fertility in mice in laboratory conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q810N1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM61-1", "uniprot_id": [ { "id": "THSD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM61", "type": "external" } ], "mass": 94696.0, "length": 851, "protein_name": "Thrombospondin type-1 domain-containing protein 1", "gene_name": "Thsd1", "organism": "Mouse", "refseq_name": "thrombospondin type-1 domain-containing protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_062522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062522", "type": "external" } ], "gene_names_uniprotkb": "Thsd1; Tmtsp", "gene_names_refseq": "4833423O18Rik; Thsd1; Tmtsp", "protein_names_uniprotkb": "Thrombospondin type-1 domain-containing protein 1; Transmembrane molecule with thrombospondin module", "protein_names_refseq": "thrombospondin type-1 domain-containing protein 1 isoform 1 precursor; thrombospondin type-1 domain-containing protein 1; transmembrane molecule with thrombospondin module", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); intracranial berry aneurysm 12 (Disease Ontology:DOID:0080975)", "pathway": " (mmu:56229); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16455951;21183079;21750661;26822228;27895300;30084848;34428180;35820727", "class_list": "", "function": "Expression profiling of Tmtsp demonstrated its specific expression in hematopoietic and endothelial cells, [RefSeq, PubMed]; Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix., [UniProtKB, UniProtKB]; THSD1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7Q9", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0048041 focal adhesion assembly;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JM61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23950-1", "uniprot_id": [ { "id": "TISB_MOUSE", "url": "https://www.uniprot.org/uniprot/P23950", "type": "external" } ], "mass": 36385.0, "length": 338, "protein_name": "mRNA decay activator protein ZFP36L1", "gene_name": "Zfp36l1", "organism": "Mouse", "refseq_name": "mRNA decay activator protein ZFP36L1", "refseq_ac": [ { "id": "NP_031590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031590", "type": "external" } ], "gene_names_uniprotkb": "Zfp36l1; Brf1; Tis11b", "gene_names_refseq": "Berg36; Brf1; D530020L18Rik; ERF1; TIS11b; Zfp36l1; cMG1", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36L1; Butyrate response factor 1; TPA-induced sequence 11b; ZFP36-like 1; Zinc finger protein 36, C3H1 type-like 1", "protein_names_refseq": "TPA-induced sequence 11b; ZFP36-like 1; butyrate response factor 1; mRNA decay activator protein ZFP36L1; zinc finger protein 36, C3H1 type-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12192); (R-MMU-450385)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11796723;15226444;15465005;17013884;17889962;19179481;1996120;20622884;21750661;22701344;23046558;24700863;24733888;25815583;26180518;27102483;30084848", "class_list": "", "function": "Results suggest that lack of Zfp36L1 expression during mid-gestation results in the abnormal stabilization of one or more mRNAs whose encoded proteins lead directly or indirectly to abnormal placentation and fetal death., [RefSeq, PubMed]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22701344, PubMed:24700863, PubMed:24733888, PubMed:27102483). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylating complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:22701344, PubMed:24700863, PubMed:24733888). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (By similarity). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (PubMed:24733888). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (By similarity). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (PubMed:27102483). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in vasculogenesis and endocardial development (PubMed:15226444, PubMed:17013884). Involved in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity). Plays a role in myoblast cell differentiation (PubMed:17889962)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0003342 proepicardium development;GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:0097403 cellular response to raffinose;GO:1902172 regulation of keratinocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P23950-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2APB8-1", "uniprot_id": [ { "id": "TPX2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2APB8", "type": "external" } ], "mass": 85894.0, "length": 745, "protein_name": "Targeting protein for Xklp2", "gene_name": "Tpx2", "organism": "Mouse", "refseq_name": "targeting protein for Xklp2", "refseq_ac": [ { "id": "NP_001135447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447", "type": "external" } ], "gene_names_uniprotkb": "Tpx2", "gene_names_refseq": "2610005B21Rik; DIL2; REPP86; Tpx2; p100", "protein_names_uniprotkb": "Targeting protein for Xklp2", "protein_names_refseq": "TPX2, microtubule-associated protein homolog; targeting protein for Xklp2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72119); (R-MMU-6804756); (R-MMU-8854518)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17242355;18663142;19144319;21183079;22872234;23806337;25605945;27753540;28528544;31219806;34428180", "class_list": "", "function": "Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U500;Q6P9S6", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0006915 apoptotic process;GO:0032147 activation of protein kinase activity;GO:0007020 microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2APB8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY73-1", "uniprot_id": [ { "id": "TMM59_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY73", "type": "external" } ], "mass": 36314.0, "length": 323, "protein_name": "Transmembrane protein 59", "gene_name": "Tmem59", "organism": "Mouse", "refseq_name": "transmembrane protein 59 precursor", "refseq_ac": [ { "id": "NP_083841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083841", "type": "external" } ], "gene_names_uniprotkb": "Tmem59; ORF18; Tdcf1", "gene_names_refseq": "1110001M20Rik; 3110046P06Rik; D4Ertd20e; MTDCF1; ORF18; Tmem59", "protein_names_uniprotkb": "Transmembrane protein 59; Thymic dendritic cell-derived factor 1", "protein_names_refseq": "thymic dendritic cell-derived factor 1; transmembrane protein 59 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:56374); (R-MMU-9013407); (R-MMU-9696273)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16393994;18365309;21183079;21750661;21955788;22336716;26495903;34583192;35606143;37506857", "class_list": "", "function": "A preliminary study on abnormal brain function and autistic behavior in mice caused by dcf1 deletion., [RefSeq, PubMed]; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis., [RefSeq, PubMed]; Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice., [RefSeq, PubMed]; Overexpression of the dcf1 gene, the NSCs were maintained in undifferentiated status. After the dcf1 gene was silenced, cells tended to differentiate into neurons and astrocytes., [RefSeq, PubMed]; The expression of tmem59 is an important factor contributing to Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWB4;Q99LY8;Q9D1P9", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006914 autophagy;GO:0010508 positive regulation of autophagy;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QY73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35235-1", "uniprot_id": [ { "id": "TNF11_MOUSE", "url": "https://www.uniprot.org/uniprot/O35235", "type": "external" } ], "mass": 35003.0, "length": 316, "protein_name": "Tumor necrosis factor ligand superfamily member 11", "gene_name": "Tnfsf11", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 11", "refseq_ac": [ { "id": "NP_035743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035743", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf11; Opgl; Rankl; Trance", "gene_names_refseq": "Ly109l; ODF; OPGL; RANKL; Tnfsf11; Trance", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 11; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; TRANCE", "protein_names_refseq": "OPG ligand; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor-related activation-induced cytokine", "tax_id": 10090, "disease": "autosomal recessive osteopetrosis 2 (Disease Ontology:DOID:0110943); osteoporosis (Disease Ontology:DOID:11476); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); myocardial infarction (Disease Ontology:DOID:5844); myocarditis (Disease Ontology:DOID:820); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:21943); (R-MMU-5668541); (R-MMU-5669034); (R-MMU-5676594); (R-MMU-9856649)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10196481;10224132;11250921;11581298;11733492;18586671;20483727;21514407;22437732;23039992;23395171;24039232;25428506;26644563;27336669;28973003;9312132;9367155;9520411;9568710", "class_list": "", "function": "Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor (PubMed:22437732). Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (By similarity). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:18586671, PubMed:24039232, PubMed:27336669). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35306;Q3TWY5;Q9JJK8;Q9JJK9;Q9R1Y0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001206 positive regulation of osteoclast development;GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35235-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UTY6-1", "uniprot_id": [ { "id": "THSD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UTY6", "type": "external" } ], "mass": 113243.0, "length": 1018, "protein_name": "Thrombospondin type-1 domain-containing protein 4", "gene_name": "Thsd4", "organism": "Mouse", "refseq_name": "thrombospondin type-1 domain-containing protein 4 isoform a precursor", "refseq_ac": [ { "id": "NP_001035516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035516", "type": "external" } ], "gene_names_uniprotkb": "Thsd4", "gene_names_refseq": "ADAMTSL-6; ADAMTSL6; Adamtsl4; B230114P05Rik; Thsd4", "protein_names_uniprotkb": "Thrombospondin type-1 domain-containing protein 4; A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6; ADAMTS-like protein 4; ADAMTS-like protein 6; ADAMTSL-4; ADAMTSL-6", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6; ADAMTS-like protein 4; ADAMTS-like protein 6; ADAMTSL-4; thrombospondin type-1 domain-containing protein 4 isoform a precursor; thrombospondin type-1 domain-containing protein 4", "tax_id": 10090, "disease": "thoracic aortic aneurysm (Disease Ontology:DOID:14004); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:207596); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18757743;19940141;21750661;21880733;22645316;30899004;32855533", "class_list": "", "function": "ADAMTSL6beta has a role in fibrillin-1 microfibril formation, [RefSeq, PubMed]; Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm., [RefSeq, PubMed]; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN., [UniProtKB, PubMed, PubMed, PubMed]; Results indicated that ADAMTSL-6 is a novel microfibril-associated protein that binds directly to fibrillin-1 and promotes fibrillin-1 matrix assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLE5", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0048251 elastic fiber assembly;GO:0160054 microfibril assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UTY6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKT7-1", "uniprot_id": [ { "id": "THOC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKT7", "type": "external" } ], "mass": 78686.0, "length": 683, "protein_name": "THO complex subunit 5 homolog", "gene_name": "Thoc5", "organism": "Mouse", "refseq_name": "THO complex subunit 5 homolog isoform 1", "refseq_ac": [ { "id": "NP_766026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766026", "type": "external" } ], "gene_names_uniprotkb": "Thoc5; Fmip; Kiaa0983", "gene_names_refseq": "1700060C24Rik; A430085L24Rik; Fmip; PK1.3; Sgk2; Thoc5", "protein_names_uniprotkb": "THO complex subunit 5 homolog; FMIP; Fms-interacting protein", "protein_names_refseq": "Fms interacting protein; THO complex subunit 5 homolog isoform 1; THO complex subunit 5 homolog; fms-interacting protein; serum/glucocorticoid regulated kinase 2", "tax_id": 10090, "disease": "breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:107829); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10597251;15221008;15451025;16909111;17242355;19015024;20051105;20173027;21183079;21750661;24618812;25428506;25605945;30779550;31219806;34203471;34428180;37828378", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes., [UniProtKB, UniProtKB]; FMIP influences the differentiation of C/EBP alpha gene during adipocyte differentiation of multipotent C2C12 cells., [RefSeq, PubMed]; Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development., [UniProtKB]; THOC5/Fms interacting protein is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein causes the down-regulation of THOC1, which may contribute to altered THO complex function and cell death Publication Status: Online-Only, [RefSeq, PubMed]; These results imply that murine leukemia virus requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts. Publication Status: Online-Only, [RefSeq, PubMed]; Wild-type FMIP and FMIPSS5,6AA inhibited M-CSF-mediated survival signaling, while FMIPSS5,6EE-expressing cells survived and differentiated into macrophages more efficiently than wild-type cells in the presence of M-CSF or TPA, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZU0;Q8CHR3", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000445 THO complex part of transcription export complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0000902 cell morphogenesis;GO:0008380 RNA splicing;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BKT7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWT1-1", "uniprot_id": [ { "id": "THIM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWT1", "type": "external" } ], "mass": 41830.0, "length": 397, "protein_name": "3-ketoacyl-CoA thiolase, mitochondrial", "gene_name": "Acaa2", "organism": "Mouse", "refseq_name": "3-ketoacyl-CoA thiolase, mitochondrial", "refseq_ac": [ { "id": "NP_803421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803421", "type": "external" } ], "gene_names_uniprotkb": "Acaa2", "gene_names_refseq": "0610011L04Rik; Acaa2; D18Ertd240e", "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase, mitochondrial; 2.3.1.16; 2.3.1.9; 3.1.2.-; 3.1.2.1; 3.1.2.2; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase", "protein_names_refseq": "3-ketoacyl-CoA thiolase, mitochondrial; acetyl-CoA acetyltransferase; acetyl-CoA acyltransferase; acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase); acyl-CoA hydrolase, mitochondrial; beta-ketothiolase; mitochondrial 3-oxoacyl-CoA thiolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:52538); (R-MMU-77289)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;17208939;17242355;21183079;21750661;23576753;23806337;30084848;31599954;31682939;34105348;34428180;34474245;36288343;37453647;37507081;39927985;40495125", "class_list": "", "function": "ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor beta1., [RefSeq, PubMed]; Chromatin immunoprecipitation-deep sequencing, confirmed the predominant association of OGDH and ACAA2 with H2A.Z-occupied transcription start sites and enhancers, the former of which we confirmed is conserved in both mouse and human tissue, [RefSeq, PubMed]; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIT9;Q8JZR8", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" } ], "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0016604 nuclear body;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006084 acetyl-CoA metabolic process;GO:0071456 cellular response to hypoxia;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8BWT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D771-1", "uniprot_id": [ { "id": "PACC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D771", "type": "external" } ], "mass": 40178.0, "length": 350, "protein_name": "Proton-activated chloride channel", "gene_name": "Pacc1", "organism": "Mouse", "refseq_name": "proton-activated chloride channel", "refseq_ac": [ { "id": "NP_080140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080140", "type": "external" } ], "gene_names_uniprotkb": "Pacc1; Tmem206", "gene_names_refseq": "2310028N02Rik; PAC; Pacc1; Tmem206", "protein_names_uniprotkb": "Proton-activated chloride channel; PAC; Transmembrane protein 206", "protein_names_refseq": "proton-activated chloride channel; transmembrane protein 206", "tax_id": 10090, "disease": "", "pathway": " (mmu:66950)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19144319;25605945;26495903;27802388;28011936;28935714;31023925;35984892;37828378", "class_list": "", "function": "Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9552, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0061797 pH-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9D771-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48787-1", "uniprot_id": [ { "id": "TNNI3_MOUSE", "url": "https://www.uniprot.org/uniprot/P48787", "type": "external" } ], "mass": 24259.0, "length": 211, "protein_name": "Troponin I, cardiac muscle", "gene_name": "Tnni3", "organism": "Mouse", "refseq_name": "troponin I, cardiac muscle", "refseq_ac": [ { "id": "NP_033432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033432", "type": "external" } ], "gene_names_uniprotkb": "Tnni3", "gene_names_refseq": "Tn1; Tnni3; cTnI", "protein_names_uniprotkb": "Troponin I, cardiac muscle; Cardiac troponin I", "protein_names_refseq": "cardiac troponin I; troponin I, cardiac muscle", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); hypertrophic cardiomyopathy 7 (Disease Ontology:DOID:0110313); dilated cardiomyopathy 1FF (Disease Ontology:DOID:0110459); dilated cardiomyopathy 2A (Disease Ontology:DOID:0110460); familial restrictive cardiomyopathy 1 (Disease Ontology:DOID:0111425); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299); coronary artery disease (Disease Ontology:DOID:3393); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (mmu:21954); (R-MMU-390522); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "11934831;12003851;12181153;12551921;12923217;15201148;15507454;15774859;16445938;17010989;17615373;17854829;19201758;19426736;19850940;21183079;21750661;22086914;22527640;22940544;25961037;29669813;36288343;37507081;8195157;8276817", "class_list": "", "function": "Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0031014 troponin T binding;GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0005737 cytoplasm;GO:0030017 sarcomere;GO:0030016 myofibril;GO:0097512 cardiac myofibril", "go_biological_process": "GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions;GO:0001570 vasculogenesis;GO:0003009 skeletal muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P48787-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WG7-1", "uniprot_id": [ { "id": "TRI36_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WG7", "type": "external" } ], "mass": 82791.0, "length": 729, "protein_name": "E3 ubiquitin-protein ligase Trim36", "gene_name": "Trim36", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Trim36 isoform 2", "refseq_ac": [ { "id": "NP_001164326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164326", "type": "external" } ], "gene_names_uniprotkb": "Trim36", "gene_names_refseq": "D18Wsu100e; Trim36; haprin", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Trim36; 2.3.2.27; Acrosome RBCC protein; Haprin; RING-type E3 ubiquitin transferase TRIM36; Tripartite motif-containing protein 36", "protein_names_refseq": "E3 ubiquitin-protein ligase Trim36 isoform 2; E3 ubiquitin-protein ligase Trim36; RING-type E3 ubiquitin transferase TRIM36; acrosome RBCC protein; tripartite motif-containing protein 36", "tax_id": 10090, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (mmu:28105); (R-MMU-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12917430;16434393;19232519;21750661;28087737;32311190", "class_list": "", "function": "E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Haprin-deficient spermatozoa are incapable of in vitro fertilization., [RefSeq, PubMed]; Results indicated that the novel RBCC protein Haprin plays a key role in the acrosome reaction and fertilization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNM1", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007340 acrosome reaction;GO:0000281 mitotic cytokinesis;GO:0007051 spindle organization;GO:0051726 regulation of cell cycle;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80WG7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWC0-1", "uniprot_id": [ { "id": "TPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWC0", "type": "external" } ], "mass": 83595.0, "length": 731, "protein_name": "Two pore channel protein 2", "gene_name": "Tpcn2", "organism": "Mouse", "refseq_name": "two pore channel protein 2", "refseq_ac": [ { "id": "NP_666318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666318", "type": "external" } ], "gene_names_uniprotkb": "Tpcn2; Tpc2", "gene_names_refseq": "D830047E22Rik; Gm35086; Tpcn2", "protein_names_uniprotkb": "Two pore channel protein 2; Two pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2", "protein_names_refseq": "two pore calcium channel protein 2; two pore channel protein 2; voltage-dependent calcium channel protein TPC2", "tax_id": 10090, "disease": "pigmentation disease (Disease Ontology:DOID:10123); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:233979); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "19387438;19557428;20495006;20547763;21750661;22833668;23063126;23394946;25144390;25722412;27231233;29187734;32167471;34428180;36744839", "class_list": "", "function": "(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm., [UniProtKB, PubMed]; Analysis of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes, [RefSeq, PubMed]; Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:19387438, PubMed:20495006, PubMed:20547763, PubMed:25144390, PubMed:27231233). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy (PubMed:23063126, PubMed:23394946, PubMed:25144390). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis (PubMed:32167471). Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites (PubMed:19387438, PubMed:20495006, PubMed:20547763, PubMed:23063126, PubMed:23394946, PubMed:25144390, PubMed:32167471). Also expressed in melanosomes of pigmented cells where mediates a Ca(2+) channel and/or PI(3,5)P2-activated melanosomal Na(+) channel to acidify pH and inhibit tyrosinase activity required for melanogenesis and pigmentation (PubMed:27231233). Unlike the voltage-dependent TPCN1, TPCN2 is voltage independent and can be activated solely by PI(3,5)P2 binding. In contrast, PI(4,5)P2, PI(3,4)P2, PI(3)P and PI(5)P have no obvious effect on channel activation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Proteins mediate a key NAADP-regulated tissue response brought about by agonist activation of a cell surface recepto, [RefSeq, PubMed]; Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons., [RefSeq, PubMed]; TPC2 is a novel critical molecule for osteoclastogenesis., [RefSeq, PubMed]; TPCN2 is a major component of the long-sought lysosomal NAADP-dependent Ca(2+)-release channel., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6NSV0;Q8BTJ7;Q8R396", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0005262 calcium channel activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0010506 regulation of autophagy;GO:0019722 calcium-mediated signaling;GO:0006874 intracellular calcium ion homeostasis;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BWC0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4K4-1", "uniprot_id": [ { "id": "TRIB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4K4", "type": "external" } ], "mass": 41281.0, "length": 372, "protein_name": "Tribbles homolog 1", "gene_name": "Trib1", "organism": "Mouse", "refseq_name": "tribbles homolog 1", "refseq_ac": [ { "id": "NP_653132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653132", "type": "external" } ], "gene_names_uniprotkb": "Trib1; Trb1", "gene_names_refseq": "A530090O15Rik; TRB-1; Trb1; Trib1", "protein_names_uniprotkb": "Tribbles homolog 1; TRB-1", "protein_names_refseq": "tribbles homolog 1", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:211770)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15299019;17576771;17724128;20410507;23515163;24003916;31219806;37078290;37355685;37527035", "class_list": "", "function": "Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:20410507, PubMed:23515163). Promotes CEBPA degradation and inhibits its function (PubMed:20410507). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (PubMed:23515163, PubMed:24003916). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (PubMed:23515163). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Describe suppression of adipocyte differentiation by TRBs Trib1, Trib2, Trib3, [RefSeq, PubMed]; TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response. Publication Status: Online-Only, [RefSeq, PubMed]; The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR[+] CD8[+] effector state, and its deletion improves checkpoint blockade., [RefSeq, PubMed]; These results demonstrate that Trib1 is a negative regulator of NF-IL6 protein expression and modulates NF-IL6-dependent gene expression in toll-like receptors-mediated signaling., [RefSeq, PubMed]; Trib1 Deficiency Promotes Hyperlipidemia, Inflammation, and Atherosclerosis in LDL Receptor Knockout Mice., [RefSeq, PubMed]; Trib1 transduced hematopoietic stem cells developed acute myeloid leukemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFS7;Q8BJR9;Q8BZX3;Q91W04", "ec_number_list": [], "go_molecular_function": "GO:0055106 ubiquitin-protein transferase regulator activity;GO:0019901 protein kinase binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045645 positive regulation of eosinophil differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide;GO:0014912 negative regulation of smooth muscle cell migration;GO:0048662 negative regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K4K4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MS8-1", "uniprot_id": [ { "id": "TPGS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MS8", "type": "external" } ], "mass": 32626.0, "length": 303, "protein_name": "Tubulin polyglutamylase complex subunit 1", "gene_name": "Tpgs1", "organism": "Mouse", "refseq_name": "tubulin polyglutamylase complex subunit 1", "refseq_ac": [ { "id": "NP_683736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683736", "type": "external" } ], "gene_names_uniprotkb": "Tpgs1; Gm16517; Gtrgeo22", "gene_names_refseq": "Gm16517; Gtrgeo22; PGs1; Tpgs1", "protein_names_uniprotkb": "Tubulin polyglutamylase complex subunit 1; PGs1; p32", "protein_names_refseq": "PGs1 protein p32; gene trap ROSA b-geo 22; tubulin polyglutamylase complex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:110012)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12242242;12972506;15890843;17360631;21750661;25605945;31219806;36210013", "class_list": "", "function": "Constitutes a tubulin polyglutamylase complex., [RefSeq, PubMed]; Mutation results in a gross loss of alpha-tubulin polyglutamylation in brain, abnormal intracellular localization of a kinesin motor, KIF1A, and impaired synaptic transmission., [RefSeq, PubMed]; Mutation results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat, [RefSeq, PubMed]; Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (PubMed:12242242, PubMed:12972506, PubMed:15890843). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5Q9;Q9R0B5", "ec_number_list": [], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0030534 adult behavior;GO:0007268 chemical synaptic transmission;GO:0000226 microtubule cytoskeleton organization;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99MS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922Y2-1", "uniprot_id": [ { "id": "TRI59_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922Y2", "type": "external" } ], "mass": 47238.0, "length": 403, "protein_name": "Tripartite motif-containing protein 59", "gene_name": "Trim59", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 59", "refseq_ac": [ { "id": "NP_080139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080139", "type": "external" } ], "gene_names_uniprotkb": "Trim59; Mrf1", "gene_names_refseq": "2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1; Trim59", "protein_names_uniprotkb": "Tripartite motif-containing protein 59; 2.3.2.27; RING finger protein 1", "protein_names_refseq": "RING finger 1; RING finger protein 1; tripartite motif-containing protein 59; tumor suppressor TSBF1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66949)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12095697;21750661;22588174;25428506;29467473;33045573;34428180;37729796;38291200;38992114", "class_list": "", "function": "E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:29467473). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (PubMed:29467473)., [UniProtKB, PubMed, UniProtKB, PubMed]; E3 ubiquitin ligase involved in different processes such as development and immune response. Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT. Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination., [UniProtKB, UniProtKB]; TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages., [RefSeq, PubMed]; TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3. Publication Status: Online-Only, [RefSeq, PubMed]; Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKA7;Q9CSP2;Q9CUD5;Q9D740", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0016567 protein ubiquitination;GO:0046597 host-mediated suppression of symbiont invasion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q922Y2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1R2-1", "uniprot_id": [ { "id": "TRIM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1R2", "type": "external" } ], "mass": 80774.0, "length": 744, "protein_name": "Tripartite motif-containing protein 3", "gene_name": "Trim3", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 3 isoform a", "refseq_ac": [ { "id": "NP_001272799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272799", "type": "external" } ], "gene_names_uniprotkb": "Trim3; Hac1; Rnf22", "gene_names_refseq": "BERP1; HAC1; Rnf22; Trim3", "protein_names_uniprotkb": "Tripartite motif-containing protein 3; 2.3.2.27; RING finger protein 22; RING finger protein HAC1", "protein_names_refseq": "RING finger protein HAC1; ring finger protein 22; tripartite motif protein 3; tripartite motif-containing protein 3 isoform a; tripartite motif-containing protein 3", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:55992)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11331580;16452087;20543135;21183079;21750661;24086586;26527743;30084848;32878999;33253119;34428180;35820727;37212515", "class_list": "", "function": "Brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner, [RefSeq, PubMed]; E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:24086586, PubMed:26527743). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation (By similarity). Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (PubMed:26527743). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A. Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:26527743). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway., [RefSeq, PubMed]; TRIM3 inhibits colorectal cancer cell migration and lipid droplet formation by promoting FABP4 degradation., [RefSeq, PubMed]; Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMU5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0030425 dendrite", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0015031 protein transport;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R1R2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWY8-1", "uniprot_id": [ { "id": "TYB10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWY8", "type": "external" } ], "mass": 5026.0, "length": 44, "protein_name": "Thymosin beta-10", "gene_name": "Tmsb10", "organism": "Mouse", "refseq_name": "thymosin beta-10", "refseq_ac": [ { "id": "NP_001034481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034481", "type": "external" } ], "gene_names_uniprotkb": "Tmsb10; Ptmb10", "gene_names_refseq": "Ptmb10; Tb10; Tmsb10", "protein_names_uniprotkb": "Thymosin beta-10", "protein_names_refseq": "thymosin beta-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:19240)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;24623079;25605945;26495903;28011936;31219806;32782141;34428180", "class_list": "", "function": "Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tbeta10 has multiple functions in the developmental course from initiation to root formation of the tooth germ, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2M3", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6ZWY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UE37-1", "uniprot_id": [ { "id": "UBE2Z_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UE37", "type": "external" } ], "mass": 38368.0, "length": 356, "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "Ube2z", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 Z", "refseq_ac": [ { "id": "NP_758504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758504", "type": "external" } ], "gene_names_uniprotkb": "Ube2z; D11Moh35", "gene_names_refseq": "C030047H17Rik; D11Moh35; Ube2z", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 Z; 2.3.2.23; E2 ubiquitin-conjugating enzyme Z; Uba6-specific E2 conjugating enzyme 1; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z; Use1", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme Z; uba6-specific E2 conjugating enzyme 1; ubiquitin carrier protein Z; ubiquitin-conjugating enzyme E2 Z; ubiquitin-conjugating enzyme E2Z (putative); ubiquitin-protein ligase Z; use1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268470); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6M3;Q3TFZ8;Q3U618;Q7TMY6;Q8BVL2;Q9DAU4", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UE37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U5Q9-1", "uniprot_id": [ { "id": "UIMC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U5Q9", "type": "external" } ], "mass": 81478.0, "length": 727, "protein_name": "BRCA1-A complex subunit RAP80", "gene_name": "Uimc1", "organism": "Mouse", "refseq_name": "BRCA1-A complex subunit RAP80 isoform 2", "refseq_ac": [ { "id": "NP_001280589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280589", "type": "external" } ], "gene_names_uniprotkb": "Uimc1; Rap80; Rip110; Rxrip110", "gene_names_refseq": "9430016E08Rik; D330018D10Rik; D630032M02Rik; RIP110; Rxrip110; Uimc1", "protein_names_uniprotkb": "BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1", "protein_names_refseq": "BRCA1-A complex subunit RAP80 isoform 2; BRCA1-A complex subunit RAP80; receptor-associated protein 80; retinoid X receptor interacting protein 110; ubiquitin interaction motif-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20184); (R-MMU-5689901); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "12954732;19536136;21183079;21750661;22689573;22896338;33300544;34428180;35938958;36852467;39172790;40997131;7760852", "class_list": "", "function": "A model in which SUMO and Ub modification is coordinated to recruit Rap80 and BRCA1 to DNA damage sites., [RefSeq, PubMed]; Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition., [RefSeq, PubMed]; DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair., [RefSeq, PubMed]; Data indicate that RAP80-deficiency promotes genomic instability and causes an increase in cancer risk consistent with the concept that RAP80 exhibits a tumor suppressor function., [RefSeq, PubMed]; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19536136). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU77;Q60811;Q8C3Z8;Q8C719;Q8K1X7", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0046965 nuclear retinoid X receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0070531 BRCA1-A complex;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5U5Q9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XC3-1", "uniprot_id": [ { "id": "US6NL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XC3", "type": "external" } ], "mass": 93574.0, "length": 819, "protein_name": "USP6 N-terminal-like protein", "gene_name": "Usp6nl", "organism": "Mouse", "refseq_name": "USP6 N-terminal-like protein isoform b", "refseq_ac": [ { "id": "NP_001074017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074017", "type": "external" } ], "gene_names_uniprotkb": "Usp6nl; Kiaa0019", "gene_names_refseq": "RNTRE; TRE2NL; Usp6nl; mKIAA0019", "protein_names_uniprotkb": "USP6 N-terminal-like protein", "protein_names_refseq": "USP6 N-terminal-like protein isoform b; USP6 N-terminal-like protein; novel TBC domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:98910); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;21183079;24239119;31219806;34428180", "class_list": "", "function": "Acts as a GTPase-activating protein for RAB43, RAB5A and RAB30. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex., [UniProtKB, UniProtKB]; These findings identify RN-tre as the Rab5-GAP that spatiotemporally controls focal adhesion remodeling during chemotactic cell migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR45;A2AR46;Q3U2W3;Q6ZQK8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007030 Golgi organization;GO:0019068 virion assembly;GO:0048227 plasma membrane to endosome transport;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80XC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z49-1", "uniprot_id": [ { "id": "UIF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Z49", "type": "external" } ], "mass": 35887.0, "length": 317, "protein_name": "UAP56-interacting factor", "gene_name": "Fyttd1", "organism": "Mouse", "refseq_name": "UAP56-interacting factor isoform 2", "refseq_ac": [ { "id": "NP_001152821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152821", "type": "external" } ], "gene_names_uniprotkb": "Fyttd1; Uif", "gene_names_refseq": "2010005M05Rik; 3830411L18Rik; 3830421F13Rik; 4933423A17Rik; Fyttd1", "protein_names_uniprotkb": "UAP56-interacting factor; Forty-two-three domain-containing protein 1; Protein 40-2-3", "protein_names_refseq": "UAP56-interacting factor isoform 2; UAP56-interacting factor; forty-two-three domain-containing protein 1; protein 40-2-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69823); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;22872859;25428506;30084848;30779550;34428180", "class_list": "", "function": "Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9859, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ68;Q3UT89;Q8BVM8;Q8K361;Q921B0;Q9D6A8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006406 mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91Z49-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY01-1", "uniprot_id": [ { "id": "ULK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY01", "type": "external" } ], "mass": 112877.0, "length": 1037, "protein_name": "Serine/threonine-protein kinase ULK2", "gene_name": "Ulk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase ULK2", "refseq_ac": [ { "id": "NP_038909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038909", "type": "external" } ], "gene_names_uniprotkb": "Ulk2; Kiaa0623", "gene_names_refseq": "A830085I22Rik; Ulk2; Unc51.2; mKIAA0623", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK2; 2.7.11.1; Serine/threonine-protein kinase Unc51.2; Unc-51-like kinase 2", "protein_names_refseq": "serine/threonine-protein kinase ULK2; serine/threonine-protein kinase Unc51.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:29869)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10557072;10624947;15014045;16887332;18443221;21183079;21258367;21460634;22517741;22645316;22826440;30084848;32848054;34428180;34678516;35104184;35822049;40885482", "class_list": "", "function": "Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80TV7;Q9WTP4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0007165 signal transduction;GO:0010506 regulation of autophagy;GO:0042594 response to starvation;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9QY01-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUP7-1", "uniprot_id": [ { "id": "UCHL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUP7", "type": "external" } ], "mass": 37617.0, "length": 329, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "gene_name": "Uchl5", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2", "refseq_ac": [ { "id": "NP_001153338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153338", "type": "external" } ], "gene_names_uniprotkb": "Uchl5; Uch37", "gene_names_refseq": "5830413B11Rik; Uch37; Uchl5", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L5; 3.4.19.12; UCH-L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5", "protein_names_refseq": "UCH-L5; ubiquitin C-terminal hydrolase 37; ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin thioesterase L5", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658)", "pathway": " (mmu:56207); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "21048919;21750661;23341450;23806337;30084848;30779550;31219806;32296042;34428180;35820727;36210013;36778113;37044315;37507081", "class_list": "", "function": "Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome., [RefSeq, PubMed]; NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs. Publication Status: Online-Only, [RefSeq, PubMed]; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity)., [UniProtKB]; This is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVJ4;Q9CXZ3;Q9R107", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0045880 positive regulation of smoothened signaling pathway;GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WUP7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AY13-1", "uniprot_id": [ { "id": "UBP24_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AY13", "type": "external" } ], "mass": 294001.0, "length": 2617, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 24", "gene_name": "Usp24", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 24", "refseq_ac": [ { "id": "NP_899048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899048", "type": "external" } ], "gene_names_uniprotkb": "Usp24", "gene_names_refseq": "2700066K03Rik; 2810030C21Rik; B130021E18; Usp24", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 24; 3.4.19.12; Deubiquitinating enzyme 24; Ubiquitin thioesterase 24; Ubiquitin-specific-processing protease 24", "protein_names_refseq": "deubiquitinating enzyme 24; ubiquitin carboxyl-terminal hydrolase 24; ubiquitin specific protease 24; ubiquitin thioesterase 24; ubiquitin thiolesterase 24; ubiquitin-specific-processing protease 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:329908); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17947660;18630941;19144319;21183079;21750661;22645316;25428506;25605945;30084848;30779550;31219806;33355202;34428180;38056575", "class_list": "", "function": "Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity)., [UniProtKB]; USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma., [RefSeq, PubMed]; Upregulation of NF-kappaB by USP24 aggravates ferroptosis in diabetic cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLI7", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "B1AY13-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE47-1", "uniprot_id": [ { "id": "UBA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE47", "type": "external" } ], "mass": 44790.0, "length": 403, "protein_name": "Ubiquitin-like modifier-activating enzyme 5", "gene_name": "Uba5", "organism": "Mouse", "refseq_name": "ubiquitin-like modifier-activating enzyme 5", "refseq_ac": [ { "id": "NP_079968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079968", "type": "external" } ], "gene_names_uniprotkb": "Uba5", "gene_names_refseq": "5730525G14Rik; Uba5; Ube1dc1", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme 5", "protein_names_refseq": "UFM1-activating enzyme; ubiquitin-activating enzyme 5; ubiquitin-activating enzyme E1 domain-containing protein 1; ubiquitin-activating enzyme E1-domain containing 1; ubiquitin-like modifier-activating enzyme 5", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 44 (Disease Ontology:DOID:0080424); autosomal recessive spinocerebellar ataxia 24 (Disease Ontology:DOID:0111615)", "pathway": " (mmu:66663); (R-MMU-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20018847;21183079;21304510;21750661;30084848;33372156;33811063", "class_list": "", "function": "A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy. Publication Status: Online-Only, [RefSeq, PubMed]; E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:21304510). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (By similarity). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (By similarity). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (By similarity). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (By similarity). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:33372156). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (PubMed:21304510)., [UniProtKB, UniProtKB, PubMed, PubMed]; The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG27;Q3U8X9;Q3U9E7;Q9CYD6", "ec_number_list": [], "go_molecular_function": "GO:0071566 UFM1 activating enzyme activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0008641 ubiquitin-like modifier activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0050905 neuromuscular process;GO:0030218 erythrocyte differentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VE47-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08747-1", "uniprot_id": [ { "id": "UNC5C_MOUSE", "url": "https://www.uniprot.org/uniprot/O08747", "type": "external" } ], "mass": 103063.0, "length": 931, "protein_name": "Netrin receptor UNC5C", "gene_name": "Unc5c", "organism": "Mouse", "refseq_name": "netrin receptor UNC5C isoform 2 precursor", "refseq_ac": [ { "id": "NP_033498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033498", "type": "external" } ], "gene_names_uniprotkb": "Unc5c; Rcm; Unc5h3", "gene_names_refseq": "B130051O18Rik; Unc5c; Unc5h3; rcm", "protein_names_uniprotkb": "Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; Rostral cerebellar malformation protein", "protein_names_refseq": "UNC-5 homolog 3; netrin receptor UNC5C isoform 2 precursor; netrin receptor UNC5C; rostral cerebellar malformation protein; unc-5 homolog C; unc5 homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22253)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10399920;11533026;12451134;21183079;21750661;22405201;22685302;25419706;28483977;9126743;9389662", "class_list": "", "function": "Receptor for netrin required for axon guidance (PubMed:22685302). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:22685302). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302). Also involved in corticospinal tract axon guidance independently of DCC (PubMed:12451134, PubMed:9126743, PubMed:9389662). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CD16", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0015631 tubulin binding;GO:0005042 netrin receptor activity;GO:0005043 netrin receptor activity involved in chemorepulsion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007420 brain development;GO:0030334 regulation of cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08747-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81615-1", "uniprot_id": [ { "id": "UCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P81615", "type": "external" } ], "mass": 13558.0, "length": 122, "protein_name": "Urocortin", "gene_name": "Ucn", "organism": "Mouse", "refseq_name": "urocortin preproprotein", "refseq_ac": [ { "id": "NP_001332939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001332939", "type": "external" } ], "gene_names_uniprotkb": "Ucn", "gene_names_refseq": "Mpv17; Ucn1; Ucn", "protein_names_uniprotkb": "Urocortin", "protein_names_refseq": "urocortin preproprotein", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); thromboangiitis obliterans (Disease Ontology:DOID:12918); dilated cardiomyopathy (Disease Ontology:DOID:12930); asthma (Disease Ontology:DOID:2841); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:22226); (R-MMU-373080)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10690896;12091910;20937857;25358399;25473847;27053649;28140406;9628819", "class_list": "", "function": "Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%. Publication Status: Online-Only, [RefSeq, PubMed]; Hormone that plays a central role in whole body adaptation to stress (PubMed:12091910, PubMed:20937857). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptors CRHR1 and CRHR2 (By similarity). UCN-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Plays a role in the establishment of normal hearing thresholds (PubMed:12091910). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; It is shown that CRH and UCN upregulate galectin-1 expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1. Publication Status: Online-Only, [RefSeq, PubMed]; Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus, [RefSeq, PubMed]; This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]., [RefSeq]; This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation., [RefSeq, PubMed]; Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88390;Q14A76", "ec_number_list": [], "go_molecular_function": "GO:0046811 histone deacetylase inhibitor activity;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0051430 corticotropin-releasing hormone receptor 1 binding;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0001964 startle response;GO:2000252 negative regulation of feeding behavior;GO:0001934 positive regulation of protein phosphorylation;GO:0006979 response to oxidative stress;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P81615-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCJ3-3", "uniprot_id": [ { "id": "UFL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCJ3", "type": "external" } ], "mass": 89520.0, "length": 793, "protein_name": "E3 UFM1-protein ligase 1", "gene_name": "Ufl1", "organism": "Mouse", "refseq_name": "E3 UFM1-protein ligase 1", "refseq_ac": [ { "id": "NP_080470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080470", "type": "external" } ], "gene_names_uniprotkb": "Ufl1; Kiaa0776; Maxer; Rcad", "gene_names_refseq": "1810074P20Rik; Kiaa0776; Maxer; Rcad; Ufl1; mKIAA0776", "protein_names_uniprotkb": "E3 UFM1-protein ligase 1; 2.3.2.-; E3 UFM1-protein transferase 1; Multiple alpha-helix protein located at ER; Regulator of C53/LZAP and DDRGK1", "protein_names_refseq": "E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; multiple alpha-helix protein located at ER; regulator of C53/LZAP and DDRGK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67490); (R-MMU-983168)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "17208939;17242355;20228063;20484733;20531390;21494687;21952136;22872234;24129315;25428506;25605945;25952549;28575669;29461087;30084848;30354401;30701081;31219806;34418053;34428180;36210013;37131258;37795761;38377992;39627609", "class_list": "", "function": "E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:28575669, PubMed:37795761, PubMed:38377992). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (PubMed:28575669, PubMed:37795761, PubMed:38377992). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (By similarity). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:25952549, PubMed:29461087, PubMed:30701081). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (PubMed:38377992). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (By similarity). Mediates ufmylation of TP53/p53, promoting its stability (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis (PubMed:25952549)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Results identify a novel molecule named multiple alpha-helix protein located at ER (Maxer) downregulated by mutant ataxin-1 (Atx1) in Bergmann glia., [RefSeq, PubMed]; UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RSP7;B1AXU5;B1AXU6;Q3V145;Q6ZQ50;Q8BT70;Q8C484;Q9D8I8", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0019901 protein kinase binding;GO:0061666 UFM1 ligase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0032790 ribosome disassembly;GO:0060252 positive regulation of glial cell proliferation;GO:0044546 NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8CCJ3-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5H1-1", "uniprot_id": [ { "id": "UBP15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5H1", "type": "external" } ], "mass": 112325.0, "length": 981, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 15", "gene_name": "Usp15", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 15 isoform 2", "refseq_ac": [ { "id": "NP_001288557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288557", "type": "external" } ], "gene_names_uniprotkb": "Usp15; Kiaa0529", "gene_names_refseq": "4921514G19Rik; E430033I05Rik; Gcap18; Usp15", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 15; 3.4.19.12; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15", "protein_names_refseq": "deubiquitinating enzyme 15; granule cell antiserum positive 18; ubiquitin carboxyl-terminal hydrolase 15 isoform 2; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin thioesterase 15; ubiquitin thiolesterase 15; ubiquitin-specific-processing protease 15", "tax_id": 10090, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:14479); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;12532266;17242355;21183079;21750661;24852371;25153642;25428506;28135057;30084848;30779550;30874560;31219806;31599954;34428180;37507081;37874479", "class_list": "", "function": "Both mouse and human have 22 exons with identical splice sites and an exon/intron structure identical to the mouse Usp4 gene., [RefSeq, PubMed]; Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy., [RefSeq, PubMed]; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGF5;Q3TTB2;Q3UL25;Q3UZH0;Q80TY6;Q80UK9", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0042802 identical protein binding;GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:1905035 negative regulation of antifungal innate immune response;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R5H1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62394-1", "uniprot_id": [ { "id": "ZN185_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62394", "type": "external" } ], "mass": 38322.0, "length": 352, "protein_name": "Zinc finger protein 185", "gene_name": "Zfp185; Znf185", "organism": "Mouse", "refseq_name": "zinc finger protein 185 isoform b", "refseq_ac": [ { "id": "NP_001102513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102513", "type": "external" } ], "gene_names_uniprotkb": "Zfp185; Znf185; Zfp185", "gene_names_refseq": "P1; Zfp185; Znf185", "protein_names_uniprotkb": "Zinc finger protein 185; LIM domain protein Zfp185; P1-A", "protein_names_refseq": "LIM domain protein Zfp185; P1-A; zinc finger protein 185 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:22673)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;28627666;36631535;8828036", "class_list": "", "function": "May be involved in the regulation of cellular proliferation and/or differentiation., [UniProtKB]; ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; ZNF185 was highly expressed in Leydig cells of the testis and involved in the secretion of testosterone and the knockdown of ZNF185 expression did not significantly affect cell cycle progression or apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62394-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1N0-1", "uniprot_id": [ { "id": "ZN830_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1N0", "type": "external" } ], "mass": 40658.0, "length": 363, "protein_name": "Zinc finger protein 830", "gene_name": "Znf830", "organism": "Mouse", "refseq_name": "zinc finger protein 830", "refseq_ac": [ { "id": "NP_080160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080160", "type": "external" } ], "gene_names_uniprotkb": "Znf830; Ccdc16; Omcg1; Zfp830", "gene_names_refseq": "2410003C20Rik; Ccdc16; Omcg1; Zfp830; Znf830", "protein_names_uniprotkb": "Zinc finger protein 830; Coiled-coil domain-containing protein 16; Ovus mutant candidate gene 1 protein", "protein_names_refseq": "coiled-coil domain containing 16; coiled-coil domain-containing protein 16; zinc finger protein 830", "tax_id": 10090, "disease": "", "pathway": " (mmu:66983); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-72163)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "15345747;15988037;17242355;17525332;21183079;21191184;22872234;23213458;25168238;30779550;34428180", "class_list": "", "function": "May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity (PubMed:15988037, PubMed:21191184, PubMed:23213458, PubMed:25168238). During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation (PubMed:21191184). Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells (PubMed:23213458). During the embryo preimplantation, controls different aspects of M phase (PubMed:15988037). During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (PubMed:25168238)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Omcg1 disruption results in the lengthening of M phase and it is an important regulator of the cell cycle in the preimplantation embryo. GeneRIF: Phenotype of knock-out mice suggests that Omcg1 (Ccdc16) is a key regulator of the cell cycle in the preimplantation mouse embryo, [RefSeq, PubMed]; Omcg1 plays a role in the tight coupling between mRNA pathways and maintenance of genome integrity during cell cycle progression., [RefSeq, PubMed]; Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR52;Q9CWV9;Q9CYI6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0005694 chromosome", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0006396 RNA processing;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R1N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERU3-1", "uniprot_id": [ { "id": "ZNF22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERU3", "type": "external" } ], "mass": 27294.0, "length": 237, "protein_name": "Zinc finger protein 22", "gene_name": "Znf22", "organism": "Mouse", "refseq_name": "zinc finger protein 22", "refseq_ac": [ { "id": "NP_001289368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289368", "type": "external" } ], "gene_names_uniprotkb": "Znf22; Krox25; Krox26; Zfp422", "gene_names_refseq": "2900028O21Rik; KOX15; Krox-25-2; Krox-26; Krox25; Krox26; Zfp422; Znf22", "protein_names_uniprotkb": "Zinc finger protein 22; Zinc finger protein 422; Zinc finger protein Krox-25; Zinc finger protein Krox-26", "protein_names_refseq": "Kruppel type zinc finger protein Krox26; zinc finger protein 22; zinc finger protein Krox-25; zinc finger protein Krox-26", "tax_id": 10090, "disease": "", "pathway": " (mmu:67255)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12489153;12952191;14630903;14706453;23806337;31685980;34428180", "class_list": "", "function": "Analysis revealed an intense expression of Krox-25 mRNA in rat and mouse teeth; results suggest that Krox-25 plays an important role as a transcription factor for the cytodifferentiation and amelogenesis of enamel epithelium., [RefSeq, PubMed]; Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation., [UniProtKB, PubMed, PubMed]; Human gene locus mapping assoicated with permanent tooth agenesis, [RefSeq, PubMed]; This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]; Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF83;Q8VEK7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0042476 odontogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ERU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNM2-1", "uniprot_id": [ { "id": "TRI46_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNM2", "type": "external" } ], "mass": 83432.0, "length": 759, "protein_name": "Tripartite motif-containing protein 46", "gene_name": "Trim46", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 46 isoform 2", "refseq_ac": [ { "id": "NP_898858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898858", "type": "external" } ], "gene_names_uniprotkb": "Trim46; Trific", "gene_names_refseq": "TRIFIC; Trim46", "protein_names_uniprotkb": "Tripartite motif-containing protein 46; Gene Y protein; GeneY; Tripartite, fibronectin type-III and C-terminal SPRY motif protein", "protein_names_refseq": "geneY; tripartite motif-containing protein 46 isoform 2; tripartite motif-containing protein 46; tripartite, fibronectin type III and C-terminal SPRY motif-containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:360213)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16434393;21183079;21750661;26671463;31461655;33556457;39251352;8597643", "class_list": "", "function": "Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS., [RefSeq, PubMed]; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration., [UniProtKB, PubMed]; TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM46 defines a unique axonal cytoskeletal compartment for regulating microtubule organization during neuronal development., [RefSeq, PubMed]; The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q60717;Q6P1I9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0044304 main axon;GO:0015630 microtubule cytoskeleton;GO:1904115 axon cytoplasm;GO:0043194 axon initial segment;GO:1990769 proximal neuron projection", "go_biological_process": "GO:0099612 protein localization to axon;GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0032880 regulation of protein localization;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TNM2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCZ2-1", "uniprot_id": [ { "id": "TM45B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCZ2", "type": "external" } ], "mass": 32388.0, "length": 278, "protein_name": "Transmembrane protein 45B", "gene_name": "Tmem45b", "organism": "Mouse", "refseq_name": "transmembrane protein 45B", "refseq_ac": [ { "id": "NP_659185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659185", "type": "external" } ], "gene_names_uniprotkb": "Tmem45b", "gene_names_refseq": "Tmem45b", "protein_names_uniprotkb": "Transmembrane protein 45B", "protein_names_refseq": "transmembrane protein 45B", "tax_id": 10090, "disease": "", "pathway": " (mmu:235135)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;36322717", "class_list": "", "function": "Plays a role in innate immunity (By similarity). Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity (PubMed:36322717)., [UniProtKB, UniProtKB, PubMed]; Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNB2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0048265 response to pain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VCZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AZA5-1", "uniprot_id": [ { "id": "TM245_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AZA5", "type": "external" } ], "mass": 97357.0, "length": 876, "protein_name": "Transmembrane protein 245", "gene_name": "Tmem245", "organism": "Mouse", "refseq_name": "transmembrane protein 245 isoform 2", "refseq_ac": [ { "id": "NP_001356189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001356189", "type": "external" } ], "gene_names_uniprotkb": "Tmem245; D730040F13Rik", "gene_names_refseq": "A630051L19Rik; D730040F13Rik; Tmem245", "protein_names_uniprotkb": "Transmembrane protein 245", "protein_names_refseq": "likely ortholog of H. sapiens chromosome 9 open reading frame 5 (C9orf5); transmembrane 245; transmembrane protein 245 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:242474)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;19131326;19144319;21183079;21750661;25605945;30084848;30899004;31219806;34428180;40021952", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "B1AZA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TX08-1", "uniprot_id": [ { "id": "TRM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TX08", "type": "external" } ], "mass": 72373.0, "length": 663, "protein_name": "tRNA (guanine(26)-N(2))-dimethyltransferase", "gene_name": "Trmt1", "organism": "Mouse", "refseq_name": "tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1", "refseq_ac": [ { "id": "NP_001158031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158031", "type": "external" } ], "gene_names_uniprotkb": "Trmt1; D8Ertd812e", "gene_names_refseq": "6720406L13Rik; 6720477L24; D8Ertd812e; Trmt1", "protein_names_uniprotkb": "tRNA (guanine(26)-N(2))-dimethyltransferase; 2.1.1.216; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase", "protein_names_refseq": "TRM1 tRNA methyltransferase 1 homolog; n(2),N(2)-dimethylguanosine tRNA methyltransferase; tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1; tRNA (guanine(26)-N(2))-dimethyltransferase; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 68 (Disease Ontology:DOID:0081229)", "pathway": " (mmu:212528)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;25428506;25428507;25605945;29237092;30084848;30779550;31219806;34428180", "class_list": "", "function": "Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IZW7;Q3TBY4;Q8R2M8", "ec_number_list": [ { "id": "2.1.1.216", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.216", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0160104 tRNA (guanine(26)-N2)-dimethyltransferase activity;GO:0016423 tRNA (guanine) methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0002940 tRNA N2-guanine methylation;GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3TX08-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K284-1", "uniprot_id": [ { "id": "TF3C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K284", "type": "external" } ], "mass": 237476.0, "length": 2101, "protein_name": "General transcription factor 3C polypeptide 1", "gene_name": "Gtf3c1", "organism": "Mouse", "refseq_name": "general transcription factor 3C polypeptide 1", "refseq_ac": [ { "id": "NP_997122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997122", "type": "external" } ], "gene_names_uniprotkb": "Gtf3c1", "gene_names_refseq": "Gtf3c1", "protein_names_uniprotkb": "General transcription factor 3C polypeptide 1; TF3C-alpha; TFIIIC 220 kDa subunit; TFIIIC box B-binding subunit; TFIIIC220; Transcription factor IIIC 220 kDa subunit; Transcription factor IIIC subunit alpha", "protein_names_refseq": "TF3C-alpha; TFIIIC 220 kDa subunit; TFIIIC box B-binding subunit; TFIIIC220; general transcription factor 3C polypeptide 1; transcription factor IIIC 220 kDa subunit; transcription factor IIIC subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:233863); (R-MMU-76061); (R-MMU-76066)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11741993;17242355;21183079;21750661;25428506;30084848;31219806;34428180;37761933", "class_list": "", "function": "Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity)., [UniProtKB]; The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; The partial purification of pol III transcription factors from PE and EC cells revealed that TFIIIC2 activity could be purified from both cell types, whereas TFIIIC1 activity was dramatically reduced in extracts from PE cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAL9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K284-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBY1-1", "uniprot_id": [ { "id": "SYVN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBY1", "type": "external" } ], "mass": 67296.0, "length": 612, "protein_name": "E3 ubiquitin-protein ligase synoviolin", "gene_name": "Syvn1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase synoviolin", "refseq_ac": [ { "id": "NP_001158181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158181", "type": "external" } ], "gene_names_uniprotkb": "Syvn1; Hrd1; Kiaa1810", "gene_names_refseq": "1200010C09Rik; D530017H19Rik; Hrd1; Syvn1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase synoviolin; 2.3.2.27; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1", "protein_names_refseq": "E3 ubiquitin-protein ligase synoviolin; RING-type E3 ubiquitin transferase synoviolin; synoviolin 1", "tax_id": 10090, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:74126); (R-MMU-5358346)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12975321;15519674;15611074;16055742;17059562;17170702;21750661;21911472;25428506;27064360;29907570;30084848;30779550;34428180;35820727;38378757;38423151;38815686;39455574", "class_list": "", "function": "Dysregulated SYVN1 promotes CAV1 protein ubiquitination and accentuates ischemic stroke., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12975321, PubMed:15611074). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12975321, PubMed:15611074). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Required for embryogenesis (PubMed:15611074). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (PubMed:21911472). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (PubMed:29907570)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion. Publication Status: Online-Only, [RefSeq, PubMed]; HRD1-mediated ubiquitination of HDAC2 regulates PPARalpha-mediated autophagy and alleviates metabolic-associated fatty liver disease., [RefSeq, PubMed]; Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD. Publication Status: Online-Only, [RefSeq, PubMed]; Synoviolin has an indispensable role in embryogenesis, [RefSeq, PubMed]; Transcriptional regulation of synoviolin via EBS-1 (ETS binding site) plays an important role in cellular homeostasis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80T88;Q8CGB5", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0001701 in utero embryonic development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9DBY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V09-1", "uniprot_id": [ { "id": "WDR13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V09", "type": "external" } ], "mass": 53664.0, "length": 485, "protein_name": "WD repeat-containing protein 13", "gene_name": "Wdr13", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 13 isoform 1", "refseq_ac": [ { "id": "NP_080413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080413", "type": "external" } ], "gene_names_uniprotkb": "Wdr13", "gene_names_refseq": "1700060B08Rik; 5730411P10Rik; DXHXS7467e; Wdr13; mMg21", "protein_names_uniprotkb": "WD repeat-containing protein 13", "protein_names_refseq": "WD repeat-containing protein 13 isoform 1; WD repeat-containing protein 13; memory-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73447)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.3389/fragi.2021.757801;16094675;21750661;22517741;22645316;22715406;24129315;26306915;28222755;30369599;32848054;32883989;34428180;35822049;40021952;40885482", "class_list": "", "function": "Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Results provide evidence that WDR13 is a novel transcriptional activator of AP1 target genes in the presence of JNK signal. The lack of Wdr13 gene conferred protection to a large extent against colitis-induced colorectal tumor in mice through reduced expression of AP1 target genes. Publication Status: Online-Only, [RefSeq, PubMed]; Using two types of heterozygous females carrying either maternally and paternally derived mutant Wdr13 allele we provide genetic evidence that development of placenta determines body weight of mice for the entire life. Publication Status: Online-Only, [RefSeq, PubMed]; WDR13 is a novel negative regulator of the pancreatic beta cell proliferation., [RefSeq, PubMed]; WDR13 is localized to the locus XA1.1 and is predominantly expressed in the testis., [RefSeq, PubMed]; Wdr13(-/0) mice exhibited higher serum insulin levels, better glucose clearance and significantly higher number of proliferating beta-cells; reiterating the finding that absence of WDR13 helps in beta-cell hyper-proliferation and recovery from diabetes Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0034451 centriolar satellite;GO:0005634 nucleus", "go_biological_process": "GO:1904691 negative regulation of type B pancreatic cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q91V09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35598-1", "uniprot_id": [ { "id": "ADA10_MOUSE", "url": "https://www.uniprot.org/uniprot/O35598", "type": "external" } ], "mass": 83968.0, "length": 749, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "Adam10", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 10 preproprotein", "refseq_ac": [ { "id": "NP_031425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031425", "type": "external" } ], "gene_names_uniprotkb": "Adam10; Kuz; Madm", "gene_names_refseq": "1700031C13Rik; Adam10; MADM; kuzbanian; kuz", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 10; 3.4.24.81; ADAM 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease", "protein_names_refseq": "a disintegrin and metalloprotease domain (ADAM) 10; disintegrin and metalloproteinase domain-containing protein 10 preproprotein; disintegrin and metalloproteinase domain-containing protein 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); reticulate acropigmentation of Kitamura (Disease Ontology:DOID:0060258); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease 18 (Disease Ontology:DOID:0110050); Alzheimer's disease (Disease Ontology:DOID:10652); thoracic aortic aneurysm (Disease Ontology:DOID:14004); status epilepticus (Disease Ontology:DOID:1824); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11487); (R-MMU-1474228); (R-MMU-381426); (R-MMU-6798695); (R-MMU-8957275); (R-MMU-9013507)", "pathway_count": 6, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;10958785;17245433;17322886;19224205;19349973;20173027;21183079;21750661;22872234;23035126;23676497;25428506;26668317;26740625;26876177;28011936;28068307;29325091;29397483;29430990;30084848;30446855;30463011;30639848;30779550;30899004;34428180;35820727;35984892;37828378;38863060;39123091;9244301", "class_list": "", "function": "Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Non-canonical function of ADAM10 in presynaptic plasticity. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]., [RefSeq]; Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:17245433, PubMed:29325091, PubMed:29430990, PubMed:30639848). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26668317, PubMed:30463011, PubMed:9244301). Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|-Leu-688' (By similarity). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (PubMed:9244301). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (PubMed:28068307). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (PubMed:29325091). Cleaves NRCAM (PubMed:29430990). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (PubMed:29397483, PubMed:30446855). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (PubMed:30639848). May regulate the EFNA5-EPHA3 signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B8JJJ0", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "3.4.24.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.86", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0017124 SH3 domain binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006509 membrane protein ectodomain proteolysis;GO:0007162 negative regulation of cell adhesion;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "O35598-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C006-1", "uniprot_id": [ { "id": "TRI35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C006", "type": "external" } ], "mass": 57345.0, "length": 501, "protein_name": "E3 ubiquitin-protein ligase TRIM35", "gene_name": "Trim35", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM35", "refseq_ac": [ { "id": "NP_084255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084255", "type": "external" } ], "gene_names_uniprotkb": "Trim35; Hls5; Kiaa1098; Mair", "gene_names_refseq": "0710005M05Rik; A430106H13Rik; HLS5; Mair; NC8; Trim35; mKIAA1098", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM35; 2.3.2.27; Hemopoietic lineage switch protein 5; Macrophage-derived apoptosis-inducing RBCC protein; Protein MAIR; Protein Nc8", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM35; hemopoietic lineage switch protein 5; macrophage-derived apoptosis-inducing RBCC protein; protein Nc8; tripartite motif-containing protein 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:66854)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12692137;14662771;15345747;20529561;21750661;31219806;32562145;34203471;34428180;35421414;38860363;39304904", "class_list": "", "function": "A novel RING-B-box-coiled-coil (RBCC) protein that consists of an N-terminal RING finger, followed by a B-box zinc finger, a coiled-coil domain, and a B30.2 domain; cloning and characterization, [RefSeq, PubMed]; C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response (By similarity) (PubMed:32562145). Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity)., [UniProtKB, UniProtKB, PubMed]; Isolated from monocytoid variant, but not parental J2E erythroleukemia cells; expressed in wide range of adult tissues; at different stages of embryogenesis, Hls5 was detected in the branchial arches, spinal cord, dorsal root ganglia, limb buds, and brain, [RefSeq, PubMed]; TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure., [RefSeq, PubMed]; TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H681;Q6ZPY0;Q7TQL7;Q810V7;Q8BVY9;Q8VID4;Q9CW74;Q9D208", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C006-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0V1-1", "uniprot_id": [ { "id": "TERB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0V1", "type": "external" } ], "mass": 86835.0, "length": 768, "protein_name": "Telomere repeats-binding bouquet formation protein 1", "gene_name": "Terb1", "organism": "Mouse", "refseq_name": "telomere repeats-binding bouquet formation protein 1", "refseq_ac": [ { "id": "NP_851289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851289", "type": "external" } ], "gene_names_uniprotkb": "Terb1; Ccdc79", "gene_names_refseq": "4930532D21Rik; Ccdc79; Terb1", "protein_names_uniprotkb": "Telomere repeats-binding bouquet formation protein 1; Coiled-coil domain-containing protein 79", "protein_names_refseq": "coiled-coil domain containing 79; coiled-coil domain-containing protein 79; telomere repeats-binding bouquet formation protein 1", "tax_id": 10090, "disease": "spermatogenic failure 60 (Disease Ontology:DOID:0112355)", "pathway": " (mmu:320022)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17660561;21750661;24413433;24885367;26548954;29083414;30718482;32408858;34428180", "class_list": "", "function": "Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis (PubMed:24413433, PubMed:24885367, PubMed:26548954). Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA (PubMed:26548954). In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment' (PubMed:26548954). Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex (PubMed:24413433, PubMed:24885367). Also recruits cohesin to telomeres to develop structural rigidity (PubMed:24413433)., [UniProtKB, PubMed, PubMed, PubMed]; The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans. Publication Status: Online-Only, [RefSeq, PubMed]; The coiled-coil-domain containing protein 79 (CCDC79) is a meiosis specific telomere-associated protein in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope Publication Status: Online-Only, [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L2Z9;E9QPF2;Q14CI1;Q8C0N5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0007129 homologous chromosome pairing at meiosis;GO:1990918 double-strand break repair involved in meiotic recombination;GO:0045141 meiotic telomere clustering", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C0V1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51830-1", "uniprot_id": [ { "id": "ADCY9_MOUSE", "url": "https://www.uniprot.org/uniprot/P51830", "type": "external" } ], "mass": 150954.0, "length": 1353, "protein_name": "Adenylate cyclase type 9", "gene_name": "Adcy9", "organism": "Mouse", "refseq_name": "adenylate cyclase type 9 isoform 1", "refseq_ac": [ { "id": "NP_033754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033754", "type": "external" } ], "gene_names_uniprotkb": "Adcy9", "gene_names_refseq": "AC9; ACtp10; Adcy9; D16Wsu65e; mKIAA0520", "protein_names_uniprotkb": "Adenylate cyclase type 9; 4.6.1.1; AC9; ACTP10; ATP pyrophosphate-lyase 9; Adenylate cyclase type IX; Adenylyl cyclase 9; Adenylyl cyclase type 10", "protein_names_refseq": "ATP pyrophosphate-lyase 9; adenylate cyclase type 9 isoform 1; adenylate cyclase type 9; adenylate cyclase type IX; adenylyl cyclase 9; adenylyl cyclase type 10", "tax_id": 10090, "disease": "newborn respiratory distress syndrome (Disease Ontology:DOID:12716); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:11515); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;34428180;37054880;7528319;7575502;8662814", "class_list": "", "function": "Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice., [RefSeq, PubMed]; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and by beta-adrenergic receptors., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61279", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51830-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88573-1", "uniprot_id": [ { "id": "AFF1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88573", "type": "external" } ], "mass": 131558.0, "length": 1216, "protein_name": "AF4/FMR2 family member 1", "gene_name": "Aff1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aff1; Mllt2h; Mllt2", "gene_names_refseq": "", "protein_names_uniprotkb": "AF4/FMR2 family member 1; Protein AF-4; Proto-oncogene AF4", "protein_names_refseq": "", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:17355)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;34428180;9880680", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0032783 super elongation complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0050877 nervous system process;GO:0045893 positive regulation of DNA-templated transcription;GO:0006354 DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88573-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59016-1", "uniprot_id": [ { "id": "VP33B_MOUSE", "url": "https://www.uniprot.org/uniprot/P59016", "type": "external" } ], "mass": 70526.0, "length": 617, "protein_name": "Vacuolar protein sorting-associated protein 33B", "gene_name": "Vps33b", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 33B isoform 1", "refseq_ac": [ { "id": "NP_835171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835171", "type": "external" } ], "gene_names_uniprotkb": "Vps33b", "gene_names_refseq": "Vps33b", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 33B", "protein_names_refseq": "vacuolar protein sorting-associated protein 33B isoform 1; vacuolar protein sorting-associated protein 33B", "tax_id": 10090, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); arthrogryposis, renal dysfunction, and cholestasis 1 (Disease Ontology:DOID:0111353); cholestasis (Disease Ontology:DOID:13580); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:233405)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;18299400;19224205;20173027;20190753;21411634;21750661;21952136;25428506;25947942;30084848;30779550;31219806;32152506;34203471;34428180;34732466;35705052;35820727;37828378", "class_list": "", "function": "Abnormal protein trafficking and impairment in multivesicular bodies maturation in Megakaryocytes underlie the alpha-granule deficiency in Vps33b(fl/fl)-ER(T2) mouse and ARC patients., [RefSeq, PubMed]; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (By similarity). Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating in part VIPAS39 (By similarity). In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependentrecycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (PubMed:25947942)., [UniProtKB, PubMed, PubMed, UniProtKB]; Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation., [RefSeq, PubMed]; Vps33B in Dendritic Cells Regulates House Dust Mite-Induced Allergic Lung Inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070889 platelet alpha granule organization;GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0030199 collagen fibril organization;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P59016-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M6U3-1", "uniprot_id": [ { "id": "TEX14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M6U3", "type": "external" } ], "mass": 162541.0, "length": 1450, "protein_name": "Inactive serine/threonine-protein kinase TEX14", "gene_name": "Tex14", "organism": "Mouse", "refseq_name": "inactive serine/threonine-protein kinase TEX14 isoform a", "refseq_ac": [ { "id": "NP_001186222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186222", "type": "external" } ], "gene_names_uniprotkb": "Tex14", "gene_names_refseq": "Tex14", "protein_names_uniprotkb": "Inactive serine/threonine-protein kinase TEX14; Testis-expressed sequence 14 protein; Testis-expressed sequence 14", "protein_names_refseq": "inactive serine/threonine-protein kinase TEX14 isoform a; inactive serine/threonine-protein kinase TEX14; testis-expressed protein 14; testis-expressed sequence 14 protein", "tax_id": 10090, "disease": "spermatogenic failure 23 (Disease Ontology:DOID:0070181)", "pathway": " (mmu:83560)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11279525;12711554;16118233;16549803;17383626;19020301;20176808;21183079;21364893;21750661;22245112;22405274;35820727", "class_list": "", "function": "Predicted to be localized to the nucleus, suggesting a key role in regulating gene expression during mammalian spermatogenesis., [RefSeq, PubMed]; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility, [RefSeq, PubMed]; Tex14 is expressed throughout spermatogenesis, [RefSeq, PubMed]; Tex14 is specifically expressed in testis in a cDNA subtraction screen, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGL0;Q3UT36;Q5NC10;Q5NC11;Q8CGK1;Q8CGK2;Q99MV8", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0000776 kinetochore;GO:0030496 midbody", "go_biological_process": "GO:0043063 intercellular bridge organization;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:1990830 cellular response to leukemia inhibitory factor;GO:0051306 mitotic sister chromatid separation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7M6U3-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50544-1", "uniprot_id": [ { "id": "ACADV_MOUSE", "url": "https://www.uniprot.org/uniprot/P50544", "type": "external" } ], "mass": 70875.0, "length": 656, "protein_name": "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadvl", "organism": "Mouse", "refseq_name": "very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_059062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059062", "type": "external" } ], "gene_names_uniprotkb": "Acadvl; Vlcad", "gene_names_refseq": "Acadvl; vlcad", "protein_names_uniprotkb": "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.8; 1.3.8.9; Long-chain specific acyl-CoA dehydrogenase, mitochondrial; MVLCAD; VLCAD", "protein_names_refseq": "MVLCAD; very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "very long chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080155); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:11370); (R-MMU-77305)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23281369;23576753;23806337;25428506;30084848;30779550;31599954;34428180;36288343;37453647;37507081;37558007;39927985;9680378", "class_list": "", "function": "Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains, but can also catalyze monounsaturated fatty acids such as oleate ((9Z)-octadecenoate), (9Z)-hexadecenoate, and others. In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACAD9 and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed., [UniProtKB, UniProtKB]; Remodeling of lipid landscape in high fat fed very-long chain acyl-CoA dehydrogenase null mice favors pro-arrhythmic polyunsaturated fatty acids and their downstream metabolites., [RefSeq, PubMed]; This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]., [RefSeq]; Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35289;O55133", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0006635 fatty acid beta-oxidation;GO:0009062 fatty acid catabolic process;GO:0009409 response to cold;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P50544-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12657-1", "uniprot_id": [ { "id": "ACM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P12657", "type": "external" } ], "mass": 51379.0, "length": 460, "protein_name": "Muscarinic acetylcholine receptor M1", "gene_name": "Chrm1", "organism": "Mouse", "refseq_name": "muscarinic acetylcholine receptor M1", "refseq_ac": [ { "id": "NP_001106167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106167", "type": "external" } ], "gene_names_uniprotkb": "Chrm1; Chrm-1", "gene_names_refseq": "Chrm-1; Chrm1; M1R; M1", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M1", "protein_names_refseq": "AChR M1; m1 muscarinic acetylcholine receptor protein; muscarinic acetylcholine receptor M1", "tax_id": 10090, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); asthma (Disease Ontology:DOID:2841); myasthenia gravis (Disease Ontology:DOID:437)", "pathway": " (mmu:12669); (R-MMU-390648); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21183079;21750661;2848036;38427478", "class_list": "", "function": "Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer's Disease., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q52KQ0;Q8BJN3", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse;GO:0043679 axon terminus", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0007274 neuromuscular synaptic transmission;GO:0040012 regulation of locomotion;GO:0043270 positive regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P12657-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28474-1", "uniprot_id": [ { "id": "ADHX_MOUSE", "url": "https://www.uniprot.org/uniprot/P28474", "type": "external" } ], "mass": 39548.0, "length": 374, "protein_name": "Alcohol dehydrogenase class-3", "gene_name": "Adh5", "organism": "Mouse", "refseq_name": "alcohol dehydrogenase class-3 isoform 2", "refseq_ac": [ { "id": "NP_001275507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275507", "type": "external" } ], "gene_names_uniprotkb": "Adh5; Adh-2; Adh2", "gene_names_refseq": "Adh-5; Adh3; Adh5; GSNOR", "protein_names_uniprotkb": "Alcohol dehydrogenase class-3; 1.1.1.-; 1.1.1.1; 1.1.1.284; ADH-B2; Alcohol dehydrogenase 2; Alcohol dehydrogenase 5; Alcohol dehydrogenase B2; Alcohol dehydrogenase class-III; FALDH; FDH; GSH-FDH; Glutathione-dependent formaldehyde dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase", "protein_names_refseq": "ADH-B2; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; S-nitrosoglutathione reductase; alcohol dehydrogenase 2; alcohol dehydrogenase B2; alcohol dehydrogenase class-3 isoform 2; alcohol dehydrogenase class-3; alcohol dehydrogenase class-III; glutathione-dependent formaldehyde dehydrogenase", "tax_id": 10090, "disease": "AMED syndrome (Disease Ontology:DOID:0080952); cholestasis (Disease Ontology:DOID:13580); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:11532); (R-MMU-71384)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11260719;11465105;1472709;14980227;17242355;2053480;21183079;21750661;23806337;28935714;34428180;35984892;37453647;37507081;37828378;38570588;39927985;7738026;8647091", "class_list": "", "function": "Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (By similarity). Class-III ADH is remarkably ineffective in oxidizing ethanol (By similarity). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (PubMed:11260719, PubMed:14980227)., [UniProtKB, UniProtKB, PubMed, PubMed]; GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW83;Q8C662", "ec_number_list": [ { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0005504 fatty acid binding;GO:0008270 zinc ion binding;GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0003016 respiratory system process;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P28474-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21981-1", "uniprot_id": [ { "id": "TGM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P21981", "type": "external" } ], "mass": 77061.0, "length": 686, "protein_name": "Protein-glutamine gamma-glutamyltransferase 2", "gene_name": "Tgm2", "organism": "Mouse", "refseq_name": "protein-glutamine gamma-glutamyltransferase 2", "refseq_ac": [ { "id": "NP_033399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033399", "type": "external" } ], "gene_names_uniprotkb": "Tgm2", "gene_names_refseq": "G[a]h; TG2; TGase2; Tgm2; tTGas; tTG", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 2; 2.3.1.-; 2.3.2.13; 3.4.-.-; 3.5.1.44; Isopeptidase TGM2; Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; TG2; TGase II; TGase-2; TGase2; Tissue transglutaminase; Transglutaminase II; Transglutaminase-2; tTG", "protein_names_refseq": "C polypeptide; TG(C); TGC; TGase C; TGase II; TGase-2; isopeptidase TGM2; protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; tissue transglutaminase; transglutaminase C; transglutaminase II; transglutaminase-2", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524)", "pathway": " (mmu:21817)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10200571;10334875;11113189;11274171;12205028;12810961;15905580;1670766;19644512;20489165;21750661;22142843;22759359;23806337;26495903;32116663;34428180;35820727;36288343;37453647;37507081;38959068;39009200;8626785", "class_list": "", "function": "Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (By similarity). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:11113189, PubMed:11274171, PubMed:20489165). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:12810961, PubMed:15905580). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:32116663). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (PubMed:32116663). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:11274171)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells., [RefSeq, PubMed]; Transglutaminase 2 knockout mice are protected from bleomycin-induced lung fibrosis with preserved lung function and reduced metabolic derangements., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88901;Q3TLV2;Q8C217;Q91VG9;Q9R1F7", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:1903672 positive regulation of sprouting angiogenesis;GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P21981-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YX0-1", "uniprot_id": [ { "id": "THMS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YX0", "type": "external" } ], "mass": 74378.0, "length": 663, "protein_name": "Protein THEMIS2", "gene_name": "Themis2", "organism": "Mouse", "refseq_name": "protein THEMIS2", "refseq_ac": [ { "id": "NP_001028480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028480", "type": "external" } ], "gene_names_uniprotkb": "Themis2; Icb1", "gene_names_refseq": "ICB-1; Themis2", "protein_names_uniprotkb": "Protein THEMIS2; Induced by contact to basement membrane 1 protein; Protein ICB-1; Thymocyte-expressed molecule involved in selection protein 2", "protein_names_refseq": "basement membrane-induced protein; induced by contact to basement membrane 1 protein; protein ICB-1; protein THEMIS2; thymocyte-expressed molecule involved in selection protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230787)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19597497;19597499;20644716;22732588;24907343;26495903;27992403;34428180;37938555;38619282", "class_list": "", "function": "Data indicate that Themis2 protein is not required for B cell development, for activation, or for antibody responses either to model Ags or to influenza viral infection., [RefSeq, PubMed]; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (PubMed:27992403)., [UniProtKB, PubMed, PubMed]; Study hypothesise that Themis2 may constitute a novel, physiological control point in macrophage inflammatory responses. Publication Status: Online-Only, [RefSeq, PubMed]; THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling., [RefSeq, PubMed]; Themis2 regulates natural killer cell memory function and formation. Publication Status: Online-Only, [RefSeq, PubMed]; This stuidy identifies a unique function for Themis2 in differential signaling and provide insight into how B cells discriminate between antigens of different quantity and quality, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5K5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0050852 T cell receptor signaling pathway;GO:0050864 regulation of B cell activation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91YX0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UF7-1", "uniprot_id": [ { "id": "TCAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UF7", "type": "external" } ], "mass": 79230.0, "length": 732, "protein_name": "TIR domain-containing adapter molecule 1", "gene_name": "Ticam1", "organism": "Mouse", "refseq_name": "TIR domain-containing adapter molecule 1", "refseq_ac": [ { "id": "NP_778154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778154", "type": "external" } ], "gene_names_uniprotkb": "Ticam1; Trif", "gene_names_refseq": "TICAM-1; TRIF; Ticam1", "protein_names_uniprotkb": "TIR domain-containing adapter molecule 1; TICAM-1; TIR domain-containing adapter protein inducing IFN-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta", "protein_names_refseq": "TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1", "tax_id": 10090, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:106759); (R-MMU-140534); (R-MMU-166166); (R-MMU-2562578); (R-MMU-936964); (R-MMU-937041); (R-MMU-937072); (R-MMU-975163); (R-MMU-9824878)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "12539043;12855817;12872135;16002681;16306936;17457343;18849341;21703541;25736436;26392463;31219806;32848054;34428180;36852467", "class_list": "", "function": "Findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense, [RefSeq, PubMed]; Identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3, [RefSeq, PubMed]; Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12855817, PubMed:16002681, PubMed:21703541). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12855817, PubMed:16002681, PubMed:21703541). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12855817, PubMed:16002681, PubMed:21703541). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (PubMed:21703541)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Lps2 mutation is a distal frameshift error in Trif or Ticam-1; Trif(Lps2) homozygotes are markedly resistant to the toxic effects of LPS, and are hypersusceptible to mouse cytomegalovirus, failing to produce type I interferons when infected, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDB7;Q3UP66;Q6P6J2;Q8CIB7;Q8JZV0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80UF7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88342-1", "uniprot_id": [ { "id": "WDR1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88342", "type": "external" } ], "mass": 66407.0, "length": 606, "protein_name": "WD repeat-containing protein 1", "gene_name": "Wdr1", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 1", "refseq_ac": [ { "id": "NP_035845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035845", "type": "external" } ], "gene_names_uniprotkb": "Wdr1", "gene_names_refseq": "Aip1; D5Wsu185e; Wdr1; rede", "protein_names_uniprotkb": "WD repeat-containing protein 1; AIP1; Actin-interacting protein 1", "protein_names_refseq": "WD repeat-containing protein 1; WD40 repeat protein 1; actin-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22388); (R-MMU-114608)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10036186;17515402;18034455;18250455;21750661;23806337;24840128;25428506;25915128;30084848;31219806;32868491;33300544;34203471;34428180;36210013;37453647;37507081;37828378;39927985", "class_list": "", "function": "Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0043297 apical junction assembly;GO:0042247 establishment of planar polarity of follicular epithelium;GO:0030834 regulation of actin filament depolymerization;GO:0002446 neutrophil mediated immunity;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O88342-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R090-1", "uniprot_id": [ { "id": "VMAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R090", "type": "external" } ], "mass": 56033.0, "length": 521, "protein_name": "Chromaffin granule amine transporter", "gene_name": "Slc18a1", "organism": "Mouse", "refseq_name": "chromaffin granule amine transporter", "refseq_ac": [ { "id": "NP_694694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694694", "type": "external" } ], "gene_names_uniprotkb": "Slc18a1; Vmat1", "gene_names_refseq": "4832416I10Rik; Slc18a1; Vat1; Vmat1", "protein_names_uniprotkb": "Chromaffin granule amine transporter; Solute carrier family 18 member 1; VAT1; Vesicular amine transporter 1", "protein_names_refseq": "chromaffin granule amine transporter; solute carrier family 18 member 1; vesicular amine transporter 1", "tax_id": 10090, "disease": "von Hippel-Lindau disease (Disease Ontology:DOID:14175); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (mmu:110877)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21712771;21750661;23201251;30685272;35820727;37828378", "class_list": "", "function": "Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling., [RefSeq, PubMed]; Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:21712771). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0005335 serotonin:sodium:chloride symporter activity;GO:0015311 monoamine:proton antiporter activity", "go_cellular_component": "GO:0043195 terminal bouton;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0030667 secretory granule membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0033603 positive regulation of dopamine secretion;GO:0051612 negative regulation of serotonin uptake;GO:0090494 dopamine uptake;GO:0051610 serotonin uptake;GO:0015842 aminergic neurotransmitter loading into synaptic vesicle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1L4-1", "uniprot_id": [ { "id": "XLRS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1L4", "type": "external" } ], "mass": 25575.0, "length": 224, "protein_name": "Retinoschisin", "gene_name": "Rs1", "organism": "Mouse", "refseq_name": "retinoschisin precursor", "refseq_ac": [ { "id": "NP_035432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035432", "type": "external" } ], "gene_names_uniprotkb": "Rs1; Rs1h; Xlrs1", "gene_names_refseq": "Rs1h; Rs1; Xlrs1; tmgc1", "protein_names_uniprotkb": "Retinoschisin; X-linked juvenile retinoschisis protein homolog", "protein_names_refseq": "X-linked juvenile retinoschisis protein homolog; retinoschisin precursor; retinoschisin; retinoschisis 1 homolog", "tax_id": 10090, "disease": "X-linked juvenile retinoschisis 1 (Disease Ontology:DOID:0060763); retinoschisis (Disease Ontology:DOID:8465)", "pathway": " (mmu:20147)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10023077;10051329;10915776;11983912;17325137;20677810;21750661;36227606;38797343", "class_list": "", "function": "Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (PubMed:17325137, PubMed:20677810). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (By similarity). Required for normal structure and function of the retina (PubMed:11983912, PubMed:17325137)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides. May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells. Required for normal structure and function of the retina., [UniProtKB, UniProtKB]; Inactivation of Rs1h suggests a role of retinoschisin in retinal cell layer organization and synaptic structure, [RefSeq, PubMed]; Retinoschisin Is Required for Pineal Gland Calcification and Cellular Communication in Pinealocytes of Rats and Mice., [RefSeq, PubMed]; Targeted Expression of Retinoschisin by Retinal Bipolar Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From Photoreceptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0007155 cell adhesion;GO:0051260 protein homooligomerization;GO:0007601 visual perception;GO:0010842 retina layer formation;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z1L4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CC88-1", "uniprot_id": [ { "id": "VWA8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CC88", "type": "external" } ], "mass": 213421.0, "length": 1905, "protein_name": "von Willebrand factor A domain-containing protein 8", "gene_name": "Vwa8", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 8 isoform 1 precursor", "refseq_ac": [ { "id": "NP_082182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082182", "type": "external" } ], "gene_names_uniprotkb": "Vwa8; Kiaa0564", "gene_names_refseq": "1300010F03Rik; 4932416F07Rik; Kiaa0564; Vwa8; mKIAA0564", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 8", "protein_names_refseq": "von Willebrand factor A domain-containing protein 8 isoform 1 precursor; von Willebrand factor A domain-containing protein 8", "tax_id": 10090, "disease": "retinitis pigmentosa 97 (Disease Ontology:DOID:0061110)", "pathway": " (mmu:219189)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;25428506;28414126;29660410;30084848;31702900;34428180;37507081", "class_list": "", "function": "Analyses indicate that the mouse Vwa8 gene produces two transcripts; the full-length Vwa8a is highly expressed relative to the truncated Vwa8b transcript across all developmental time points and tissues analyzed.These data establish the development timeline and expression profile for both Vwa8a and Vwa8b., [RefSeq, PubMed]; Exhibits ATPase activity in vitro., [UniProtKB, PubMed]; The VWA8 protein was targeted exclusively to mitochondria in mouse AML12 liver cells, and this was prevented by deletion of the targeting sequence., [RefSeq, PubMed]; VWA8 null cells had higher levels of oxidative stress and protein degradation; assays of hydrogen peroxide production revealed higher levels of production of reactive oxygen species., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4P9;Q6ZQ94;Q8CDH8;Q8VCU3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CC88-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4P0-1", "uniprot_id": [ { "id": "WDR33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4P0", "type": "external" } ], "mass": 145267.0, "length": 1330, "protein_name": "pre-mRNA 3' end processing protein WDR33", "gene_name": "Wdr33", "organism": "Mouse", "refseq_name": "pre-mRNA 3' end processing protein WDR33 isoform 1", "refseq_ac": [ { "id": "NP_083142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083142", "type": "external" } ], "gene_names_uniprotkb": "Wdr33; Wdc146", "gene_names_refseq": "1110001N06Rik; 2310011G05Rik; 2810021O11Rik; 8430413N20Rik; WDC146; Wdr33", "protein_names_uniprotkb": "pre-mRNA 3' end processing protein WDR33; WD repeat-containing protein 33; WD repeat-containing protein of 146 kDa", "protein_names_refseq": "WD repeat-containing protein 33; WD repeat-containing protein WDC146; WD repeat-containing protein of 146 kDa; pre-mRNA 3' end processing protein WDR33 isoform 1; pre-mRNA 3' end processing protein WDR33", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:74320); (R-MMU-159231); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11162572;21750661;23806337;24129315;31219806", "class_list": "", "function": "Essential for both cleavage and polyadenylation of pre-mRNA 3' ends., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7C6;Q8CD02", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K4P0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R105-1", "uniprot_id": [ { "id": "VP37C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R105", "type": "external" } ], "mass": 38453.0, "length": 352, "protein_name": "Vacuolar protein sorting-associated protein 37C", "gene_name": "Vps37c", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 37C isoform 1", "refseq_ac": [ { "id": "NP_852068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852068", "type": "external" } ], "gene_names_uniprotkb": "Vps37c", "gene_names_refseq": "5730409F24Rik; Vps37c", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 37C; ESCRT-I complex subunit VPS37C", "protein_names_refseq": "ESCRT-I complex subunit VPS37C; vacuolar protein sorting-associated protein 37C isoform 1; vacuolar protein sorting-associated protein 37C", "tax_id": 10090, "disease": "", "pathway": " (mmu:107305); (R-MMU-917729)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;26495903;31219806;34428180", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY76", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0031902 late endosome membrane;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0006612 protein targeting to membrane;GO:0016236 macroautophagy;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R105-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ40-1", "uniprot_id": [ { "id": "ZIC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQ40", "type": "external" } ], "mass": 64542.0, "length": 622, "protein_name": "Zinc finger protein ZIC 5", "gene_name": "Zic5", "organism": "Mouse", "refseq_name": "zinc finger protein ZIC 5", "refseq_ac": [ { "id": "NP_075363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075363", "type": "external" } ], "gene_names_uniprotkb": "Zic5; Opr", "gene_names_refseq": "1700049L20Rik; Opr; Zic5", "protein_names_uniprotkb": "Zinc finger protein ZIC 5; Odd paired-related protein; Opa-related protein; Zinc finger protein of the cerebellum 5", "protein_names_refseq": "Zic family member 5 (odd-paired homolog, Drosophila); odd paired-related protein; odd-paired related; opa-related protein; zinc finger protein ZIC 5", "tax_id": 10090, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:65100)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11044622;15136147;15465018;21183079;21750661;30059200;36752150", "class_list": "", "function": "Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Findings suggested that Zic5 is involved in the generation of neural crest tissue in mouse development, [RefSeq, PubMed]; MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2. Publication Status: Online-Only, [RefSeq, PubMed]; Results describe the molecular properties of Zic4 and Zic5 proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQW1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030900 forebrain development;GO:0007417 central nervous system development;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TQ40-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1E1-1", "uniprot_id": [ { "id": "ZMIZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1E1", "type": "external" } ], "mass": 115851.0, "length": 1072, "protein_name": "Zinc finger MIZ domain-containing protein 1", "gene_name": "Zmiz1", "organism": "Mouse", "refseq_name": "zinc finger MIZ domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001297595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297595", "type": "external" } ], "gene_names_uniprotkb": "Zmiz1; Rai17; Zimp10", "gene_names_refseq": "E330020C23; Gm10397; I920194n01; Rai17; Zimp10; Zmiz1", "protein_names_uniprotkb": "Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; Retinoic acid-induced protein 17", "protein_names_refseq": "PIAS-like protein Zimp10; retinoic acid induced 17; retinoic acid-induced protein 17; zinc finger MIZ domain-containing protein 1 isoform 2; zinc finger MIZ domain-containing protein 1", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:328365)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16777850;16862223;23161489;25428506;26163108;26522984;30084848;34428180;36307047;38718095;40997131", "class_list": "", "function": "A physiological role for Zimp10 in regulating Smad3/4-mediated transcription is demonstrated in mouse embryonic fibroblasts., [RefSeq, PubMed]; Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (By similarity)., [UniProtKB, UniProtKB, PubMed]; Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function. Publication Status: Online-Only, [RefSeq, PubMed]; Zmiz1 is required for mature beta-cell function and mass expansion upon high fat feeding., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDK9;Q6PF85;Q8BW47", "ec_number_list": [], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0007296 vitellogenesis;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P1E1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0C0-1", "uniprot_id": [ { "id": "ZHX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0C0", "type": "external" } ], "mass": 92259.0, "length": 836, "protein_name": "Zinc fingers and homeoboxes protein 2", "gene_name": "Zhx2", "organism": "Mouse", "refseq_name": "zinc fingers and homeoboxes protein 2", "refseq_ac": [ { "id": "NP_955520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955520", "type": "external" } ], "gene_names_uniprotkb": "Zhx2; Afr1; Raf", "gene_names_refseq": "Afr-1; Afr1; Raf; Zhx2; mKIAA0854", "protein_names_uniprotkb": "Zinc fingers and homeoboxes protein 2; AFP regulator 1; Alpha-fetoprotein regulator 1; Regulator of AFP; Zinc finger and homeodomain protein 2", "protein_names_refseq": "AFP regulator 1; alpha fetoprotein regulation 1, adult; alpha-fetoprotein regulator 1; regulator of AFP; zinc finger and homeodomain protein 2; zinc fingers and homeoboxes protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:387609)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14659886;17056598;19515908;21183079;25428506;30084848;30146259;34428180;36852467;37582865;37847682;40021952;40885482;40997131", "class_list": "", "function": "Acts as a transcriptional repressor (PubMed:19515908). Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (PubMed:30146259). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (PubMed:19515908)., [UniProtKB, UniProtKB, PubMed, PubMed]; Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression., [RefSeq, PubMed]; Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045665 negative regulation of neuron differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8C0C0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12961-1", "uniprot_id": [ { "id": "7B2_MOUSE", "url": "https://www.uniprot.org/uniprot/P12961", "type": "external" } ], "mass": 23866.0, "length": 212, "protein_name": "Neuroendocrine protein 7B2", "gene_name": "Scg5", "organism": "Mouse", "refseq_name": "neuroendocrine protein 7B2 isoform a precursor", "refseq_ac": [ { "id": "NP_033188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033188", "type": "external" } ], "gene_names_uniprotkb": "Scg5; Sgne-1; Sgne1", "gene_names_refseq": "7B2; Scg5; Sgne-1; Sgne1", "protein_names_uniprotkb": "Neuroendocrine protein 7B2; Secretogranin V; Secretogranin-5; Secretory granule endocrine protein I", "protein_names_refseq": "neuroendocrine protein 7B2 isoform a precursor; neuroendocrine protein 7B2; secretogranin-5; secretory granule endocrine protein I; secretory granule neuroendocrine protein 1, 7B2 protein", "tax_id": 10090, "disease": "pituitary-dependent Cushing's disease (Disease Ontology:DOID:3946)", "pathway": " (mmu:20394)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10089884;11439082;21183079;2542174;29955078;32928873;8016065;8034690;9348280", "class_list": "", "function": "Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro., [UniProtKB, PubMed, PubMed]; Brain 7B2 can impact Abeta disposition in a manner that facilitates plaque formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCZ3;Q9CYP0;Q9D2P6;Q9DB14", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0051082 unfolded protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0030141 secretory granule", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007218 neuropeptide signaling pathway;GO:0016486 peptide hormone processing;GO:0046883 regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P12961-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYL4-1", "uniprot_id": [ { "id": "SYYM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYL4", "type": "external" } ], "mass": 52597.0, "length": 472, "protein_name": "Tyrosine--tRNA ligase, mitochondrial", "gene_name": "Yars2", "organism": "Mouse", "refseq_name": "tyrosine--tRNA ligase, mitochondrial", "refseq_ac": [ { "id": "NP_937889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937889", "type": "external" } ], "gene_names_uniprotkb": "Yars2", "gene_names_refseq": "2210023C10Rik; Yars2; tyrRS", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, mitochondrial; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "tyrosine--tRNA ligase, mitochondrial", "tax_id": 10090, "disease": "myopathy, lactic acidosis, and sideroblastic anemia 2 (Disease Ontology:DOID:0111186)", "pathway": " (mmu:70120)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;21952136;23576753;25428506;25605945;30084848;31599954;33649389;34428180;37828378", "class_list": "", "function": "Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAH7", "ec_number_list": [ { "id": "6.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding;GO:0072545 L-tyrosine binding;GO:0004831 tyrosine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0070184 mitochondrial tyrosyl-tRNA aminoacylation;GO:0043039 tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation;GO:0006437 tyrosyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BYL4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ44-1", "uniprot_id": [ { "id": "TM218_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ44", "type": "external" } ], "mass": 12464.0, "length": 115, "protein_name": "Transmembrane protein 218", "gene_name": "Tmem218", "organism": "Mouse", "refseq_name": "transmembrane protein 218 isoform 1", "refseq_ac": [ { "id": "NP_001297025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297025", "type": "external" } ], "gene_names_uniprotkb": "Tmem218", "gene_names_refseq": "1810021J13Rik; Tmem218", "protein_names_uniprotkb": "Transmembrane protein 218", "protein_names_refseq": "transmembrane protein 218 isoform 1", "tax_id": 10090, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Joubert syndrome (Disease Ontology:DOID:0050777)", "pathway": " (mmu:66279)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25161209;26982032", "class_list": "", "function": "May be involved in ciliary biogenesis or function., [UniProtKB, PubMed]; Tmem218-/- mice develop progressive cystic kidney disease and retinal degeneration, a model for Senior-Loken syndrome, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF13", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQ44-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKD8-1", "uniprot_id": [ { "id": "TBX21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKD8", "type": "external" } ], "mass": 57852.0, "length": 530, "protein_name": "T-box transcription factor TBX21", "gene_name": "Tbx21", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX21", "refseq_ac": [ { "id": "NP_062380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062380", "type": "external" } ], "gene_names_uniprotkb": "Tbx21; Tbet; Tblym", "gene_names_refseq": "TBT1; Tbet; Tblym; Tbx21", "protein_names_uniprotkb": "T-box transcription factor TBX21; T-box protein 21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM", "protein_names_refseq": "T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM", "tax_id": 10090, "disease": "immunodeficiency 88 (Disease Ontology:DOID:0061058); childhood-onset asthma (Disease Ontology:DOID:0080815); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); malaria (Disease Ontology:DOID:12365); dilated cardiomyopathy (Disease Ontology:DOID:12930); uveitis (Disease Ontology:DOID:13141); orchitis (Disease Ontology:DOID:2518); asthma (Disease Ontology:DOID:2841); autoimmune thyroiditis (Disease Ontology:DOID:7188); periapical periodontitis (Disease Ontology:DOID:823); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:57765)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10761931;11087660;11786643;11786644;11960012;15662016;17923685;21095589;21151104;21690296;23616576;25605945;27292648;27430722;28424242;28607488;28623086;29133416", "class_list": "", "function": "Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (PubMed:10761931, PubMed:17923685, PubMed:21095589). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC (PubMed:21151104). Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2 (PubMed:15662016, PubMed:21690296, PubMed:23616576). Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN- stimulated genes (PubMed:28623086). Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (PubMed:27430722)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells, [RefSeq, PubMed]; T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma., [RefSeq, PubMed]; T-bet regulates IgG class switching and pathogenic autoantibody production., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U150;Q9R0A6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0032703 negative regulation of interleukin-2 production;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0002296 T-helper 1 cell lineage commitment;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JKD8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F285-1", "uniprot_id": [ { "id": "TM256_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5F285", "type": "external" } ], "mass": 11656.0, "length": 113, "protein_name": "Transmembrane protein 256", "gene_name": "Tmem256", "organism": "Mouse", "refseq_name": "transmembrane protein 256 precursor", "refseq_ac": [ { "id": "NP_081258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081258", "type": "external" } ], "gene_names_uniprotkb": "Tmem256; 1810027O10Rik", "gene_names_refseq": "1810027O10Rik; 3110009M16Rik; Tmem256", "protein_names_uniprotkb": "Transmembrane protein 256", "protein_names_refseq": "UPF0451 protein C17orf61 homolog; transmembrane protein 256 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69186)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23576753;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5F285-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52196-1", "uniprot_id": [ { "id": "THTR_MOUSE", "url": "https://www.uniprot.org/uniprot/P52196", "type": "external" } ], "mass": 33466.0, "length": 297, "protein_name": "Thiosulfate sulfurtransferase", "gene_name": "Tst", "organism": "Mouse", "refseq_name": "thiosulfate sulfurtransferase", "refseq_ac": [ { "id": "NP_033463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033463", "type": "external" } ], "gene_names_uniprotkb": "Tst", "gene_names_refseq": "Tst; rhodanese", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase; 2.8.1.1; Rhodanese", "protein_names_refseq": "thiosulfate sulfurtransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:22117); (R-MMU-1614558)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "23576753;23806337;27287690;30084848;32444140;34428180;37453647;37507081;7488186", "class_list": "", "function": "Catalyzes the transfer of sulfur ion from thiosulfate to cyanide, although other thiol compounds, besides cyanide, can act as sulfur ion acceptors (By similarity). It also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Has a pivotal role in cyanide detoxification. Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results identified two regulatory variants between fat and lean mice: one overlaps an evolutionary constrained Tst intronic element and the other resides in the seed region of a predicted 3'UTR miRNA binding site. Publication Status: Online-Only, [RefSeq, PubMed]; Tst gene mediates protection against palmitate-induced inflammation in 3T3-L1 adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.1", "type": "external" } ], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0008097 5S rRNA binding;GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0051029 rRNA transport;GO:0030855 epithelial cell differentiation;GO:0035928 rRNA import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P52196-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62441-1", "uniprot_id": [ { "id": "TLE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62441", "type": "external" } ], "mass": 83787.0, "length": 773, "protein_name": "Transducin-like enhancer protein 4", "gene_name": "Tle4", "organism": "Mouse", "refseq_name": "transducin-like enhancer protein 4 isoform 2", "refseq_ac": [ { "id": "NP_035730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035730", "type": "external" } ], "gene_names_uniprotkb": "Tle4; Grg4", "gene_names_refseq": "5730411M05Rik; Bce-1; Bce1; ESTM13; ESTM14; Grg4; Tle4; grg-4", "protein_names_uniprotkb": "Transducin-like enhancer protein 4; Grg-4; Groucho-related protein 4", "protein_names_refseq": "B lymphocyte gene 1; groucho-related protein 4; transducin-like enhancer of split 4, homolog of Drosophila E(spl); transducin-like enhancer protein 4 isoform 2; transducin-like enhancer protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:21888); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4641265)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10811620;11266540;12050133;16314515;18254933;21183079;21317240;21606357;22517741;23371388;23990468;29237092;32782141;32848054;35822049;36852467;40021952;40885482;8892234", "class_list": "", "function": "Transcriptional corepressor that binds to a number of transcription factors (PubMed:21317240). Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling (PubMed:10811620). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (PubMed:12050133). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (PubMed:23371388)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKQ9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q62441-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2L8-1", "uniprot_id": [ { "id": "TPC12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2L8", "type": "external" } ], "mass": 87694.0, "length": 797, "protein_name": "Trafficking protein particle complex subunit 12", "gene_name": "Trappc12", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 12 isoform 1", "refseq_ac": [ { "id": "NP_001154882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154882", "type": "external" } ], "gene_names_uniprotkb": "Trappc12; Ttc15", "gene_names_refseq": "CGI-87; D930014A20Rik; Trappc12; Ttc15", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 12; TPR repeat protein 15; Tetratricopeptide repeat protein 15", "protein_names_refseq": "TPR repeat protein 15; tetratricopeptide repeat domain 15; tetratricopeptide repeat protein 15; trafficking protein particle complex subunit 12 isoform 1; trafficking protein particle complex subunit 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:217449); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;25428506;25605945;30084848;34428180", "class_list": "", "function": "Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QLQ6;Q8BX27", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:1905342 positive regulation of protein localization to kinetochore;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K2L8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J99-1", "uniprot_id": [ { "id": "THTM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J99", "type": "external" } ], "mass": 33097.0, "length": 297, "protein_name": "3-mercaptopyruvate sulfurtransferase", "gene_name": "Mpst", "organism": "Mouse", "refseq_name": "3-mercaptopyruvate sulfurtransferase", "refseq_ac": [ { "id": "NP_001155964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155964", "type": "external" } ], "gene_names_uniprotkb": "Mpst", "gene_names_refseq": "3MST; Mpst; Mst", "protein_names_uniprotkb": "3-mercaptopyruvate sulfurtransferase; 2.8.1.2; MST", "protein_names_refseq": "3-mercaptopyruvate sulfurtransferase", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:246221); (R-MMU-1614558)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "18855522;21732914;21750661;21937432;22808324;23104984;23576753;23759691;23806337;28079151;30084848;34428180;36288343;37453647;39927985", "class_list": "", "function": "Behavioral abnormality in MST-KO mice is caused by MST function defects such as an antioxidant insufficiency or a new transducer, H2S (or HS(-)) and/or SOx deficiency., [RefSeq, PubMed]; SiRNA silencing of 3-MPST reduced basal bioenergetic parameters and prevented the stimulating effect of 3-MP on mitochondrial bioenergetics., [RefSeq, PubMed]; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW66;Q505N7", "ec_number_list": [ { "id": "2.8.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.2", "type": "external" } ], "go_molecular_function": "GO:0016784 3-mercaptopyruvate sulfurtransferase activity;GO:0042802 identical protein binding;GO:0004792 thiosulfate-cyanide sulfurtransferase activity;GO:0016783 sulfurtransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0001889 liver development;GO:0021510 spinal cord development;GO:0001822 kidney development;GO:0019346 transsulfuration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99J99-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X56-1", "uniprot_id": [ { "id": "TRI69_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X56", "type": "external" } ], "mass": 57312.0, "length": 500, "protein_name": "E3 ubiquitin-protein ligase TRIM69", "gene_name": "Trim69", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM69 isoform 1", "refseq_ac": [ { "id": "NP_536771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536771", "type": "external" } ], "gene_names_uniprotkb": "Trim69; Rnf36; Trif", "gene_names_refseq": "4921519C19Rik; Rnf36; Trif; Trim69; Trimless", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM69; 2.3.2.27; RING finger B-box coiled-coil transcription factor; RING finger protein 36; RING-type E3 ubiquitin transferase TRIM69; Testis-specific RING finger protein; Tripartite motif-containing protein 69", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM69 isoform 1; E3 ubiquitin-protein ligase TRIM69; RFP-like (B30.2) domain protein; RING finger B-box coiled-coil transcription factor; RING-type E3 ubiquitin transferase TRIM69; ring finger protein 36; testis-specific RING finger protein; tripartite motif-containing protein 69", "tax_id": 10090, "disease": "", "pathway": " (mmu:70928); (R-MMU-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11578878;12837286;31178136;33273151", "class_list": "", "function": "E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1., [UniProtKB, UniProtKB]; Trim69 might be a functionally essential inhibitor of ASK1 activation during the pathogenesis of hippocampal inflammation and apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHZ6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0007098 centrosome cycle;GO:0071539 protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80X56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFW4-1", "uniprot_id": [ { "id": "TRI65_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFW4", "type": "external" } ], "mass": 58458.0, "length": 522, "protein_name": "E3 ubiquitin-protein ligase TRIM65", "gene_name": "Trim65", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM65", "refseq_ac": [ { "id": "NP_848917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848917", "type": "external" } ], "gene_names_uniprotkb": "Trim65", "gene_names_refseq": "4732463G12Rik; Trim65", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM65; 2.3.2.27; Tripartite motif-containing protein 65", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM65; tripartite motif-containing protein 65", "tax_id": 10090, "disease": "", "pathway": " (mmu:338364)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;28031478;31219806;31310649;34512673;37080331;37608612;38212319;38218012", "class_list": "", "function": "E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:31310649, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs. This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (By similarity). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade. Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (By similarity). Also plays a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673)., [UniProtKB, UniProtKB, PubMed, PubMed]; TRIM65 Suppresses oxLDL-induced Endothelial Inflammation by Interaction with VCAM-1 in Atherogenesis., [RefSeq, PubMed]; TRIM65 as an essential component for the MDA5 signaling pathway and provide physiological evidence showing that ubiquitination is important for MDA5 oligomerization and activation., [RefSeq, PubMed]; TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway., [RefSeq, PubMed]; The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3. Publication Status: Online-Only, [RefSeq, PubMed]; Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A867;Q6PGD3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0044546 NLRP3 inflammasome complex assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BFW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PJ2-1", "uniprot_id": [ { "id": "TRIM8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PJ2", "type": "external" } ], "mass": 61602.0, "length": 551, "protein_name": "E3 ubiquitin-protein ligase TRIM8", "gene_name": "Trim8", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM8 isoform 1", "refseq_ac": [ { "id": "NP_444330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444330", "type": "external" } ], "gene_names_uniprotkb": "Trim8; Gerp; Rnf27", "gene_names_refseq": "GERP; Rnf27; Trim8", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM8; 2.3.2.27; Glioblastoma-expressed RING finger protein; RING finger protein 27; RING-type E3 ubiquitin transferase TRIM8; Tripartite motif-containing protein 8", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM8 isoform 1; RING-type E3 ubiquitin transferase TRIM8; glioblastoma-expressed RING finger protein; probable E3 ubiquitin-protein ligase TRIM8; ring finger protein 27; tripartite motif protein 8; tripartite motif-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:93679)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11118312;11331580;12163497;15345195;21689689;27995356;28747347;31360105;31904480;34428180;36617827;38237865", "class_list": "", "function": "E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:28747347, PubMed:31360105). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (By similarity). Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (By similarity). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Gerp transcribes interferon-gamma in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues., [RefSeq, PubMed]; Knockdown of TRIM8 alleviates dextran sulfate sodium-induced colitis in mice by inhibiting the NF-kappaB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4alpha stability., [RefSeq, PubMed]; TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2G3;Q8C508;Q8C700;Q8CGI2;Q99PQ4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99PJ2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35561-1", "uniprot_id": [ { "id": "KCNJ2_MOUSE", "url": "https://www.uniprot.org/uniprot/P35561", "type": "external" } ], "mass": 48389.0, "length": 428, "protein_name": "Inward rectifier potassium channel 2", "gene_name": "Kcnj2", "organism": "Mouse", "refseq_name": "inward rectifier potassium channel 2", "refseq_ac": [ { "id": "NP_032451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032451", "type": "external" } ], "gene_names_uniprotkb": "Kcnj2; Irk1", "gene_names_refseq": "IRK1; Kcnf1; Kcnj2; Kir2.1", "protein_names_uniprotkb": "Inward rectifier potassium channel 2; IRK-1; Inward rectifier K(+) channel Kir2.1; Potassium channel, inwardly rectifying subfamily J member 2", "protein_names_refseq": "IRK-1; inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel 2; potassium channel, inwardly rectifying subfamily J member 2", "tax_id": 10090, "disease": "Andersen-Tawil syndrome (Disease Ontology:DOID:0050434); familial atrial fibrillation (Disease Ontology:DOID:0050650); short QT syndrome (Disease Ontology:DOID:0050793); atrial fibrillation (Disease Ontology:DOID:0060224); EAST syndrome (Disease Ontology:DOID:0060484); familial periodic paralysis (Disease Ontology:DOID:1029); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16518); (R-MMU-1296041); (R-MMU-1296053); (R-MMU-5576886); (R-MMU-997272)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "19144319;21209095;33300544;38448811;38586877;7680768;8282096;9533862", "class_list": "", "function": "Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1. Publication Status: Online-Only, [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:7680768, PubMed:8282096). Can be blocked by extracellular barium and cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Visceral adipose of obese mice inhibits endothelial inwardly rectifying K[+] channels in a CD36-dependent fashion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0086011 membrane repolarization during action potential;GO:0014861 regulation of skeletal muscle contraction via regulation of action potential;GO:0015693 magnesium ion transport;GO:0051289 protein homotetramerization;GO:0060306 regulation of membrane repolarization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35561-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ20-1", "uniprot_id": [ { "id": "M1IP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ20", "type": "external" } ], "mass": 20356.0, "length": 182, "protein_name": "Mid1-interacting protein 1", "gene_name": "Mid1ip1", "organism": "Mouse", "refseq_name": "mid1-interacting protein 1", "refseq_ac": [ { "id": "NP_001160107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160107", "type": "external" } ], "gene_names_uniprotkb": "Mid1ip1; Mig12", "gene_names_refseq": "3110038L01Rik; Mid1ip1; Mig12; S14R", "protein_names_uniprotkb": "Mid1-interacting protein 1; Gastrulation-specific G12-like protein; Mid1-interacting G12-like protein; Protein STRAIT11499 homolog; S14R; Spot 14-R; Spot 14-related protein", "protein_names_refseq": "gastrulation-specific G12-like protein; mid1-interacting G12-like protein; mid1-interacting protein 1; protein STRAIT11499 homolog; spot 14-R; spot 14-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68041); (R-MMU-200425)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15070402;15890771;17242355;18556348;20457939;20952656;21183079;21750661;34428180", "class_list": "", "function": "Mig12 is expressed in the embryonic ventral midline and co-operates with Mid1 to stabilize microtubules Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules., [UniProtKB, PubMed, PubMed, PubMed]; The S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHT5", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007026 negative regulation of microtubule depolymerization;GO:0045723 positive regulation of fatty acid biosynthetic process;GO:0051258 protein polymerization;GO:0046890 regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQ20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924X6-1", "uniprot_id": [ { "id": "LRP8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924X6", "type": "external" } ], "mass": 109818.0, "length": 996, "protein_name": "Low-density lipoprotein receptor-related protein 8", "gene_name": "Lrp8", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 8 isoform a precursor", "refseq_ac": [ { "id": "NP_444303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444303", "type": "external" } ], "gene_names_uniprotkb": "Lrp8; Apoer2", "gene_names_refseq": "4932703M08Rik; ApoER2; Lr8b; Lrp8", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 8; Apolipoprotein E receptor 2; LRP-8", "protein_names_refseq": "apolipoprotein E receptor 2; low density lipoprotein receptor relative, 8 ligand binding repeats, brain; low-density lipoprotein receptor-related protein 8 isoform a precursor; low-density lipoprotein receptor-related protein 8", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); coronary artery disease (Disease Ontology:DOID:3393); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16975); (R-MMU-432142); (R-MMU-975634)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10380922;10827199;11294845;12169628;12426372;12573468;12695510;12871934;12899622;18174160;18778775;21750661;29336888;30899004;37212552;37726747;38281682;38716730;9685741", "class_list": "", "function": "Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:10380922, PubMed:11294845, PubMed:12899622, PubMed:18778775). LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail (PubMed:10380922). Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons (PubMed:10380922). LRP8 has higher affinity for Reelin than VLDLR (PubMed:10380922, PubMed:11294845). LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development (PubMed:10380922, PubMed:11294845, PubMed:18778775). Binds the endoplasmic reticulum resident receptor-associated protein (RAP) (PubMed:12899622). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (PubMed:12695510). May also function as an endocytic receptor (PubMed:12169628). Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (PubMed:18174160). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (PubMed:29336888)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency., [RefSeq, PubMed]; Regulation of the hippocampal translatome by Apoer2-ICD release. Publication Status: Online-Only, [RefSeq, PubMed]; Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for Hereditary Spastic Paraplegia. Erratum:[Prog Neurobiol. 2024 Oct;241:102662. doi: 10.1016/j.pneurobio.2024.102662. PMID: 39294072], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAK9;Q8CDF5;Q921B6", "ec_number_list": [], "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0048306 calcium-dependent protein binding;GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0006897 endocytosis;GO:0007268 chemical synaptic transmission;GO:0021766 hippocampus development;GO:0045860 positive regulation of protein kinase activity;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q924X6-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLN9-1", "uniprot_id": [ { "id": "MTOR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLN9", "type": "external" } ], "mass": 288789.0, "length": 2549, "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "Mtor", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase mTOR", "refseq_ac": [ { "id": "NP_064393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064393", "type": "external" } ], "gene_names_uniprotkb": "Mtor; Frap1; Frap", "gene_names_refseq": "2610315D21Rik; FRAP2; FRAP; Frap1; Mtor; RAFT1; RAPT1; flat", "protein_names_uniprotkb": "Serine/threonine-protein kinase mTOR; 2.7.10.2; 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; Mechanistic target of rapamycin; RAPT1; Rapamycin target protein 1; Tyrosine-protein kinase mTOR; mTOR", "protein_names_refseq": "FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP12-rapamycin complex-associated protein; angiopoietin-like factor CDT6; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); rapamycin target protein 1; serine/threonine-protein kinase mTOR; tyrosine-protein kinase mTOR", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); crescentic glomerulonephritis (Disease Ontology:DOID:13139); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); chondrosarcoma (Disease Ontology:DOID:3371); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); kidney angiomyolipoma (Disease Ontology:DOID:8411); vascular dementia (Disease Ontology:DOID:8725); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56717); (R-MMU-1257604); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-3371571); (R-MMU-380972); (R-MMU-389357); (R-MMU-5218920); (R-MMU-5628897); (R-MMU-6804757); (R-MMU-8943724); (R-MMU-9639288); (R-MMU-9856530)", "pathway_count": 14, "publication_count": 141, "publication_id_list": "10.1101/2023.09.13.557529;10567225;11792863;11930000;14970221;15467718;15485918;15545625;16086373;16221682;16915281;16962653;17242355;17978888;18046414;18566586;18566587;18767117;19291319;19346248;19440205;19487463;19704009;20022946;20801936;21045808;21183079;21258367;21321111;21659604;21927580;21949739;22359505;23027611;23071621;23142081;23342114;23388827;23409704;23440873;24062605;24187137;24280377;24391749;24647338;24670654;24682776;24809512;24967341;25280966;25428506;25428507;25439029;25605945;25716553;25991723;26222260;26267903;26299806;26312014;26314207;26359501;26597054;26728896;26745759;26795633;26858121;27257474;27599409;27781091;27913603;27930667;28151473;28333151;28364027;28464882;28467426;28638048;28718972;28810557;28938574;28980850;29150432;29232555;29554968;29574227;29623927;29720580;29723221;29734780;29750810;29854093;29858083;30014636;30084848;30409162;30410062;30410750;30569110;30622053;30696333;30787203;30876754;30961637;30973211;31138988;31159888;31207499;31213901;31219806;31373126;31519159;31548312;31726709;31786107;31998287;32107468;32207633;32231246;32316601;32399718;32498424;32716920;32751882;33071755;33184378;33300544;33637094;33658993;33741019;33850054;33918604;34203471;34217376;34245780;34289345;34428180;35820727;36210013;39388284;7809080", "class_list": "", "function": "Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:15467718, PubMed:15485918, PubMed:15545625, PubMed:16221682, PubMed:16915281, PubMed:16962653, PubMed:18046414, PubMed:19440205, PubMed:21659604). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15467718, PubMed:15545625, PubMed:16221682, PubMed:16915281, PubMed:16962653, PubMed:18046414, PubMed:19440205, PubMed:21659604). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15467718, PubMed:16962653, PubMed:21659604). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:15485918). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:15485918). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:15485918). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (By similarity). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (By similarity). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (By similarity). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:11792863). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (PubMed:18046414). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:21258367). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:21258367). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (By similarity). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (By similarity). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (By similarity). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (By similarity). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (By similarity). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:27913603). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:27913603). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (PubMed:19346248). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:18566586, PubMed:21045808, PubMed:21321111, PubMed:24670654, PubMed:29232555, PubMed:31548312, PubMed:33850054). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:18566587, PubMed:18566586, PubMed:21045808, PubMed:21321111, PubMed:24670654, PubMed:31548312, PubMed:33850054). In contrast to mTORC1, mTORC2 is nutrient-insensitive. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:18566586, PubMed:21321111, PubMed:24670654, PubMed:33850054). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (By similarity). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (PubMed:23142081, PubMed:23388827). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR (By similarity). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (PubMed:19440205). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (PubMed:29750810)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 35, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2KHT0;Q811J5;Q9CST1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1904263 positive regulation of TORC1 signaling;GO:0050882 voluntary musculoskeletal movement;GO:1904059 regulation of locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 14.6, "record_id": "Q9JLN9-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22893-1", "uniprot_id": [ { "id": "TTP_MOUSE", "url": "https://www.uniprot.org/uniprot/P22893", "type": "external" } ], "mass": 33613.0, "length": 319, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "Zfp36", "organism": "Mouse", "refseq_name": "mRNA decay activator protein ZFP36", "refseq_ac": [ { "id": "NP_035886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035886", "type": "external" } ], "gene_names_uniprotkb": "Zfp36; Nup475; Tis11a; Tis11; Ttp", "gene_names_refseq": "Gos24; Nup475; TIS11D; TISII; Tis11; Ttp; Zfp-36; Zfp36", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; Growth factor-inducible nuclear protein NUP475; TPA-induced sequence 11; Tristetraprolin; Zfp-36; Zinc finger protein 36", "protein_names_refseq": "TPA-induced sequence 11; growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; tristetraproline; tristetraprolin", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:22695); (R-MMU-450513)", "pathway_count": 2, "publication_count": 47, "publication_id_list": "10330172;10706852;10805719;11533235;11796723;11886850;12515557;14688255;15014438;15187092;15634918;15967811;16508014;16508015;16514065;1699942;17030620;17170118;17288565;17971298;1861870;19144319;19188452;1996120;20166898;20221403;20595389;21078877;21278420;2204625;22701344;22844456;23046558;23468959;24733888;25815583;26002976;26763119;27193233;27802388;2915901;34090459;38708503;7559666;7768935;8630730;9703499", "class_list": "", "function": "Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10706852, PubMed:10805719, PubMed:15014438, PubMed:15187092, PubMed:15634918, PubMed:17030620, PubMed:19188452, PubMed:20595389, PubMed:21078877, PubMed:22701344, PubMed:27193233). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:21278420). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:21278420). Also functions by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:21278420). Self-regulates by destabilizing its own mRNA (PubMed:15187092, PubMed:17288565). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:11533235, PubMed:15187092, PubMed:16508014, PubMed:17288565, PubMed:17971298, PubMed:20595389, PubMed:21078877, PubMed:21278420, PubMed:22701344, PubMed:27193233). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (PubMed:15014438, PubMed:16514065, PubMed:8630730, PubMed:9703499). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (By similarity). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (By similarity). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (PubMed:25815583). Also associates with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (By similarity). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (By similarity). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (By similarity). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (PubMed:22844456). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (PubMed:22844456). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; [Zinc finger protein-36 deficiency inhibits osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells and preosteoblasts by activating the ERK/MAPK pathway]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11520", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0050779 RNA destabilization;GO:0032703 negative regulation of interleukin-2 production;GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:1902172 regulation of keratinocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P22893-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70280-1", "uniprot_id": [ { "id": "VAMP7_MOUSE", "url": "https://www.uniprot.org/uniprot/P70280", "type": "external" } ], "mass": 24967.0, "length": 220, "protein_name": "Vesicle-associated membrane protein 7", "gene_name": "Vamp7", "organism": "Mouse", "refseq_name": "vesicle-associated membrane protein 7 isoform 2", "refseq_ac": [ { "id": "NP_001289067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289067", "type": "external" } ], "gene_names_uniprotkb": "Vamp7; Sybl1", "gene_names_refseq": "Sybl1; TI-VAMP; VAMP-7; Vamp7", "protein_names_uniprotkb": "Vesicle-associated membrane protein 7; Synaptobrevin-like protein 1; VAMP-7", "protein_names_refseq": "synaptobrevin like 1; tetanus neurotoxin-insensitive vesicle-associated membrane protein; vesicle-associated membrane protein 7 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20955)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10564831;15470500;19144319;21952136;21998198;22872234;23217709;25428506;25605945;26740625;30084848;32652719;34428180;38029541;9302271", "class_list": "", "function": "Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation., [UniProtKB, PubMed]; Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons., [RefSeq, PubMed]; VAMP7 knockdown in secretory granules impairs CCL2 secretion in mast cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0043312 neutrophil degranulation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0008333 endosome to lysosome transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70280-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3E5-1", "uniprot_id": [ { "id": "AHI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3E5", "type": "external" } ], "mass": 119650.0, "length": 1047, "protein_name": "Jouberin", "gene_name": "Ahi1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ahi1", "gene_names_refseq": "", "protein_names_uniprotkb": "Jouberin; AHI-1; Abelson helper integration site 1 protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); autism spectrum disorder (Disease Ontology:DOID:0060041); Joubert syndrome 3 (Disease Ontology:DOID:0110998); Joubert syndrome 4 (Disease Ontology:DOID:0110999); nephronophthisis (Disease Ontology:DOID:12712); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:52906); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12186888;15467982;18633336;19625297;21565611;21623382;21750661;22179047;22645316;23658157;29899041;34428180", "class_list": "", "function": "Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium (PubMed:19625297). Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (PubMed:22179047). Involved in neuronal differentiation (PubMed:23658157). As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNV2;Q9CVY1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0034329 cell junction assembly;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K3E5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46656-1", "uniprot_id": [ { "id": "ADX_MOUSE", "url": "https://www.uniprot.org/uniprot/P46656", "type": "external" } ], "mass": 20123.0, "length": 188, "protein_name": "Adrenodoxin, mitochondrial", "gene_name": "Fdx1", "organism": "Mouse", "refseq_name": "adrenodoxin, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_001288657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288657", "type": "external" } ], "gene_names_uniprotkb": "Fdx1", "gene_names_refseq": "Fdx1", "protein_names_uniprotkb": "Adrenodoxin, mitochondrial; Adrenal ferredoxin; Ferredoxin-1", "protein_names_refseq": "adrenal ferredoxin; adrenodoxin, mitochondrial isoform 2 precursor; adrenodoxin, mitochondrial", "tax_id": 10090, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:14148); (R-MMU-1362409); (R-MMU-196108); (R-MMU-211976); (R-MMU-2395516); (R-MMU-9857492)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "21183079;21750661;23576753;23806337;36288343;37517308;38251655;7640310;7893748", "class_list": "", "function": "Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons., [UniProtKB, UniProtKB]; FDX1 regulates leydig cell ferroptosis mediates PM2.5-induced testicular dysfunction of mice., [RefSeq, PubMed]; Ferredoxin 1 is essential for embryonic development and lipid homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0051353 positive regulation of oxidoreductase activity;GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P46656-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCJ4-1", "uniprot_id": [ { "id": "AMER2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCJ4", "type": "external" } ], "mass": 69933.0, "length": 672, "protein_name": "APC membrane recruitment protein 2", "gene_name": "Amer2", "organism": "Mouse", "refseq_name": "APC membrane recruitment protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001158177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158177", "type": "external" } ], "gene_names_uniprotkb": "Amer2; Fam123a", "gene_names_refseq": "2600011E07Rik; Amer2; Fam123a", "protein_names_uniprotkb": "APC membrane recruitment protein 2; Amer2; Protein FAM123A", "protein_names_refseq": "APC membrane recruitment protein 2 isoform 2; APC membrane recruitment protein 2; family with sequence similarity 123, member A; protein FAM123A", "tax_id": 10090, "disease": "", "pathway": " (mmu:72125)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15345747;16452087;21183079;21750661;22898821;34428180", "class_list": "", "function": "Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Amer2-EB1-APC complex regulates cell migration by altering microtubule stability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNC5;Q8K0U9;Q9D0Q2", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008013 beta-catenin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0007398 ectoderm development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CCJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18654-1", "uniprot_id": [ { "id": "KS6A3_MOUSE", "url": "https://www.uniprot.org/uniprot/P18654", "type": "external" } ], "mass": 83694.0, "length": 740, "protein_name": "Ribosomal protein S6 kinase alpha-3", "gene_name": "Rps6ka3", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase alpha-3 isoform 1", "refseq_ac": [ { "id": "NP_683747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683747", "type": "external" } ], "gene_names_uniprotkb": "Rps6ka3; Mapkapk1b; Rps6ka-rs1; Rsk2", "gene_names_refseq": "MAPKAPK-1b; MPK-9; Rps6ka3; Rsk2; S6K-alpha3; p90RSK3; pp90RSK2", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-3; 2.7.11.1; 90 kDa ribosomal protein S6 kinase 3; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2; Ribosomal S6 kinase 2; S6K-alpha-3; p90-RSK 3; p90RSK3; pp90RSK2", "protein_names_refseq": "90 kDa ribosomal protein S6 kinase 3; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; ribosomal protein S6 kinase 2; ribosomal protein S6 kinase alpha-3 isoform 1; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase polypeptide 3", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 19 (Disease Ontology:DOID:0112019); intellectual disability (Disease Ontology:DOID:1059); Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (mmu:110651); (R-MMU-198753); (R-MMU-199920); (R-MMU-2559582); (R-MMU-442742); (R-MMU-444257); (R-MMU-881907)", "pathway_count": 7, "publication_count": 31, "publication_id_list": "10480933;10856237;12016217;14504289;15109498;17785202;17906627;18084304;19956600;21183079;21750661;22645316;22827337;25337589;25605945;26083344;27732676;2779569;28528544;30084848;31219806;31599954;32152506;34203471;34428180;35820727;35853487;36210013;37068088;37201672;39627609", "class_list": "", "function": "RSK2 inactivation cooperates with AXIN1 inactivation or beta-catenin activation to promote hepatocarcinogenesis., [RefSeq, PubMed]; Ribosomal S6 Protein Kinase 2 Aggravates the Process of Systemic Scleroderma., [RefSeq, PubMed]; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10856237, PubMed:15109498). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (By similarity). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (By similarity). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (By similarity). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (By similarity). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (By similarity). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:14504289). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (PubMed:17785202, PubMed:17906627). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (PubMed:22827337). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (PubMed:22827337). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (By similarity). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (PubMed:15109498)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXN4;Q03140;Q8K3J8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0038202 TORC1 signaling;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P18654-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54967-1", "uniprot_id": [ { "id": "ACK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54967", "type": "external" } ], "mass": 116975.0, "length": 1055, "protein_name": "Activated CDC42 kinase 1", "gene_name": "Tnk2", "organism": "Mouse", "refseq_name": "activated CDC42 kinase 1 isoform 2", "refseq_ac": [ { "id": "NP_001103617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103617", "type": "external" } ], "gene_names_uniprotkb": "Tnk2; Ack1", "gene_names_refseq": "Ack-1; Ack1; Ack; Cdgip; Pyk1; Tnk2", "protein_names_uniprotkb": "Activated CDC42 kinase 1; 2.7.10.2; 2.7.11.1; ACK-1; Non-receptor protein tyrosine kinase Ack; Tyrosine kinase non-receptor protein 2", "protein_names_refseq": "Cdc42 GTPase-inhibiting protein; P21cdc42Hs kinase; activated CDC42 kinase 1 isoform 2; activated CDC42 kinase 1; non-receptor protein tyrosine kinase ACK; tyrosine kinase non-receptor protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:51789); (R-MMU-9842663)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "16052498;16750431;16777958;17182860;18034455;18477472;20086093;20333297;21169560;21183079;21309750;21750661;22517741;22645316;24129315;25223282;26495903;29386546;30059200;31219806;32782141;32848054;33730447;34428180;34678516;35669783;35822049;36852467;40021952;40885482", "class_list": "", "function": "ACK1 Contributes to the Pathogenesis of Inflammation and Autoimmunity by Promoting the Activation of TLR Signaling Pathways. Publication Status: Online-Only, [RefSeq, PubMed]; ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation., [RefSeq, PubMed]; Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain., [RefSeq, PubMed]; Ack1/Pyk1 tyrosine kinase may be involved both in adult synaptic function and plasticity and in brain development., [RefSeq, PubMed]; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR., [UniProtKB, PubMed, PubMed]; These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q0Z844;Q8C2U0;Q8K0K4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007286 spermatid development;GO:2000369 regulation of clathrin-dependent endocytosis;GO:0016310 phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "O54967-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62484-1", "uniprot_id": [ { "id": "ABI2_MOUSE", "url": "https://www.uniprot.org/uniprot/P62484", "type": "external" } ], "mass": 49387.0, "length": 446, "protein_name": "Abl interactor 2", "gene_name": "Abi2", "organism": "Mouse", "refseq_name": "abl interactor 2 isoform 1", "refseq_ac": [ { "id": "NP_001185499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185499", "type": "external" } ], "gene_names_uniprotkb": "Abi2", "gene_names_refseq": "8430425M24Rik; Abi2; AblBP3; ArgBP1; C130078H13", "protein_names_uniprotkb": "Abl interactor 2; Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1", "protein_names_refseq": "abelson interactor 2; abi-2; abl interactor 2 isoform 1; abl-binding protein 3; arg-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:329165); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10995551;11516653;15572692;21183079;21750661;22517741;22645316;27605705;31219806;32848054;33300544;34428180;40021952;40684658;40885482", "class_list": "", "function": "Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (By similarity). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (By similarity). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (PubMed:15572692). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (PubMed:27605705). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (PubMed:15572692). Also required for nascent adherens junction assembly in epithelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHU3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005912 adherens junction", "go_biological_process": "GO:0007611 learning or memory;GO:0016358 dendrite development;GO:0016477 cell migration;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P62484-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8B0-1", "uniprot_id": [ { "id": "ALX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8B0", "type": "external" } ], "mass": 36931.0, "length": 326, "protein_name": "ALX homeobox protein 1", "gene_name": "Alx1", "organism": "Mouse", "refseq_name": "ALX homeobox protein 1 isoform 1", "refseq_ac": [ { "id": "NP_766141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766141", "type": "external" } ], "gene_names_uniprotkb": "Alx1; Cart1", "gene_names_refseq": "Alx1; C130005I02; Cart1", "protein_names_uniprotkb": "ALX homeobox protein 1; CART-1; Cartilage homeoprotein 1", "protein_names_refseq": "ALX homeobox protein 1 isoform 1; ALX homeobox protein 1; cartilage homeoprotein 1", "tax_id": 10090, "disease": "frontonasal dysplasia 3 (Disease Ontology:DOID:0081047)", "pathway": " (mmu:216285)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12929931;21750661;8673125", "class_list": "", "function": "Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:8673125). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C370", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0030326 embryonic limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C8B0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TS3-1", "uniprot_id": [ { "id": "AGRL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TS3", "type": "external" } ], "mass": 171080.0, "length": 1537, "protein_name": "Adhesion G protein-coupled receptor L3", "gene_name": "Adgrl3", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor L3 isoform 4 precursor", "refseq_ac": [ { "id": "NP_001334298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334298", "type": "external" } ], "gene_names_uniprotkb": "Adgrl3; Kiaa0768; Lec3; Lphn3", "gene_names_refseq": "5430402I23Rik; Adgrl3; CIRL-3; D130075K09Rik; Gm1379; LEC3; Lphn3; mKIAA0768", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L3; Latrophilin-3; Lectomedin-3", "protein_names_refseq": "G protein coupled receptor Lec3; adhesion G protein-coupled receptor L3 isoform 4 precursor; calcium-independent alpha-latrotoxin receptor homolog 3; latrophilin-3; lectomedin-3", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:319387)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;12679517;17114649;21183079;21750661;22405201;22575564;22645316;24739570;25728924;26235031;26495903;30792275;30899004;32778842;33300544;34428180;36244455;36309016;38233523;39798870", "class_list": "", "function": "Null mutant Lphn3 mice had a hyperactive phenotype in the open field test, independent of sex, and were more sensitive to locomotor stimulation., [RefSeq, PubMed]; Orphan adhesion G protein-coupled receptor (aGPCR) (PubMed:38233523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:38233523). Isoform 7 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (PubMed:38233523)., [UniProtKB, PubMed]; Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity (PubMed:36244455, PubMed:38233523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:36244455, PubMed:36309016). ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context (PubMed:32778842, PubMed:36309016, PubMed:39798870). Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient (PubMed:32778842, PubMed:36244455). Following G protein-coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity (PubMed:22405201, PubMed:25728924, PubMed:26235031, PubMed:30792275, PubMed:39798870). Specifically mediates the establishment of Schaffer-collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus (PubMed:30792275). Localizes to postsynaptic spines in excitatory synapses in the S.oriens and S.radiatum and interacts with presynaptic cell adhesion molecules FLRT3 and TENM2, promoting synapse formation (PubMed:30792275). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity (PubMed:38233523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:38233523). Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:38233523). Following G protein-coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation (PubMed:38233523)., [UniProtKB, PubMed]; Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 47, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHI7;Q3UM79;Q504Z9;Q5HZJ6;Q80T56", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0140693 molecular condensate scaffold activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030424 axon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q80TS3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXK8-1", "uniprot_id": [ { "id": "AGAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXK8", "type": "external" } ], "mass": 94411.0, "length": 857, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1", "gene_name": "Agap1", "organism": "Mouse", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001032213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032213", "type": "external" } ], "gene_names_uniprotkb": "Agap1; Centg2; Kiaa1099", "gene_names_refseq": "Agap1; Centg2; Ggap1; mKIAA1099", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; AGAP-1; Centaurin-gamma-2; Cnt-g2", "protein_names_refseq": "AGAP-1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; centaurin-gamma-2; cnt-g2", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); cerebral palsy (Disease Ontology:DOID:1969)", "pathway": " (mmu:347722)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12640130;15381706;21183079;21750661;22453919;25428506", "class_list": "", "function": "AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase, [RefSeq, PubMed]; GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity., [RefSeq, PubMed]; GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHA0;Q6ZPX9;Q8BZG0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0098845 postsynaptic endosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0099159 regulation of modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BXK8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D842-1", "uniprot_id": [ { "id": "APLF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D842", "type": "external" } ], "mass": 54968.0, "length": 499, "protein_name": "Aprataxin and PNK-like factor", "gene_name": "Aplf", "organism": "Mouse", "refseq_name": "aprataxin and PNK-like factor isoform 1", "refseq_ac": [ { "id": "NP_001163960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163960", "type": "external" } ], "gene_names_uniprotkb": "Aplf", "gene_names_refseq": "2010301N04Rik; Aplf", "protein_names_uniprotkb": "Aprataxin and PNK-like factor; 3.1.-.-; Apurinic-apyrimidinic endonuclease APLF", "protein_names_refseq": "aprataxin and PNK-like factor isoform 1; aprataxin and PNK-like factor; apurinic-apyrimidinic endonuclease APLF", "tax_id": 10090, "disease": "", "pathway": " (mmu:72103)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21211721;21750661;27875275;31599954;33277378;38968704", "class_list": "", "function": "APLF has a role in chromosomal DNA double-strand break repair., [RefSeq, PubMed]; Histone chaperone APLF level dictates the implantation of mouse embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Histone chaperone involved in single-strand and double-strand DNA break repair (By similarity). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (By similarity). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:27875275). Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (By similarity). Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (PubMed:27875275). Required for the embryo implantation during the epithelial to mesenchymal transition in females (PubMed:33277378)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells., [RefSeq, PubMed]; The downregulation of histone chaperone Aprataxin PNK-like factor (APLF) promotes reprogramming by augmenting the expression of E-cadherin. Erratum:[J Cell Sci. 2018 Apr 19;131(8):jcs218842. doi: 10.1242/jcs.218842. PMID: 29674330], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZL5;Q99LX6", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0000166 nucleotide binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0004520 DNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0090734 site of DNA damage", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D842-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHG2-1", "uniprot_id": [ { "id": "AMOT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHG2", "type": "external" } ], "mass": 120915.0, "length": 1126, "protein_name": "Angiomotin", "gene_name": "Amot", "organism": "Mouse", "refseq_name": "angiomotin isoform 2", "refseq_ac": [ { "id": "NP_001277203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277203", "type": "external" } ], "gene_names_uniprotkb": "Amot; Kiaa1071", "gene_names_refseq": "Amot; CAG-2; D0Kist1; Sii6", "protein_names_uniprotkb": "Angiomotin", "protein_names_refseq": "angiomotin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:27494); (R-MMU-2028269); (R-MMU-9762292)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12406577;17242355;21750661;22517741;22645316;23791731;25428506;29237092;30016717;30059200;30084848;32782141;32848054;34428180;36852467;40021952;40885482", "class_list": "", "function": "Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity). Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2AMJ9;A2AMK0;Q6PFB8;Q6ZPZ1", "ec_number_list": [], "go_molecular_function": "GO:0043532 angiostatin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q8VHG2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBW3-1", "uniprot_id": [ { "id": "ABI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBW3", "type": "external" } ], "mass": 52288.0, "length": 481, "protein_name": "Abl interactor 1", "gene_name": "Abi1", "organism": "Mouse", "refseq_name": "abl interactor 1 isoform 1", "refseq_ac": [ { "id": "NP_001070658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070658", "type": "external" } ], "gene_names_uniprotkb": "Abi1; Ssh3bp1", "gene_names_refseq": "Abi1; E3B1; NAP1; Ssh3bp1; abi-1", "protein_names_uniprotkb": "Abl interactor 1; Abelson interactor 1; Abi-1; Ablphilin-1; Eps8 SH3 domain-binding protein; Eps8-binding protein; Spectrin SH3 domain-binding protein 1; e3B1", "protein_names_refseq": "abelson interactor 1; abl interactor 1 isoform 1; ablphilin-1; eps8 SH3 domain-binding protein; eps8 binding protein; spectrin SH3 domain binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11308); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 7, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10499589;10995551;11477655;11516653;11526477;12672821;14765121;15143189;15558031;18034455;19131326;19144319;21183079;21750661;26428302;31219806;33300544;34203471;34428180;35820727;7590237", "class_list": "", "function": "May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8V0;Q60747;Q91ZM5;Q923I9;Q99KH4", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030296 protein tyrosine kinase activator activity;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030027 lamellipodium", "go_biological_process": "GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0001764 neuron migration;GO:0001756 somitogenesis;GO:0035855 megakaryocyte development;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8CBW3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XL6-1", "uniprot_id": [ { "id": "ACD11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XL6", "type": "external" } ], "mass": 87366.0, "length": 779, "protein_name": "Acyl-CoA dehydrogenase family member 11", "gene_name": "Acad11", "organism": "Mouse", "refseq_name": "acyl-CoA dehydrogenase family member 11", "refseq_ac": [ { "id": "NP_780533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780533", "type": "external" } ], "gene_names_uniprotkb": "Acad11", "gene_names_refseq": "5730439E10Rik; Acad11", "protein_names_uniprotkb": "Acyl-CoA dehydrogenase family member 11; 1.3.8.8; ACAD-11", "protein_names_refseq": "acyl-CoA dehydrogenase family member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:102632); (R-MMU-77289)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17242355;17768142;21750661;23576753;23806337;25428506;31219806;34428180;37453647", "class_list": "", "function": "Participates in fatty acid beta-oxidation (FAO) and energy production in the central nervous system (CNS), and to a lesser extent in the liver. Catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, with maximal activity towards saturated docosanoyl-CoA (CoA 22:0) in both the cerebellum and the liver. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACADV and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed, such as the CNS, where together with ACAD9, they accommodate the full spectrum of long chain fatty acid substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK19", "ec_number_list": [ { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity;GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046395 carboxylic acid catabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80XL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61315-1", "uniprot_id": [ { "id": "APC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61315", "type": "external" } ], "mass": 311089.0, "length": 2845, "protein_name": "Adenomatous polyposis coli protein", "gene_name": "Apc", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Apc", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenomatous polyposis coli protein; Protein APC; mAPC", "protein_names_refseq": "", "tax_id": 10090, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); medulloblastoma (Disease Ontology:DOID:0050902); familial adenomatous polyposis 1 (Disease Ontology:DOID:0080409); hereditary desmoid disease (Disease Ontology:DOID:0111349); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); adenocarcinoma (Disease Ontology:DOID:299); acinar cell carcinoma (Disease Ontology:DOID:3025); gallbladder cancer (Disease Ontology:DOID:3121); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-MMU-111465); (R-MMU-195253); (R-MMU-196299); (R-MMU-3769402); (R-MMU-4641262); (R-MMU-5689896)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;1350108;15311282;16611247;19893577;21183079;21750661;22645316;32848054;34428180;35822049;40885482;8242607", "class_list": "", "function": "Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells (PubMed:19893577). Associates with both microtubules and actin filaments, components of the cytoskeleton (By similarity). Plays a role in mediating the organization of F-actin into ordered bundles (By similarity). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (PubMed:15311282). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 25, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q62044", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0001708 cell fate specification;GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0009798 axis specification;GO:0007399 nervous system development;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q61315-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61824-1", "uniprot_id": [ { "id": "ADA12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61824", "type": "external" } ], "mass": 98504.0, "length": 903, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 12", "gene_name": "Adam12", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 12 preproprotein", "refseq_ac": [ { "id": "NP_031426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031426", "type": "external" } ], "gene_names_uniprotkb": "Adam12; Mltna", "gene_names_refseq": "5830403F22Rik; Adam12; Mltna", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 12; 3.4.24.-; ADAM 12; Meltrin-alpha", "protein_names_refseq": "a disintegrin and metallopeptidase domain 12 (meltrin alpha); a disintegrin and metalloprotease domain 12; a disintegrin and metalloproteinase domain 12 (meltrin alpha); disintegrin and metalloproteinase domain-containing protein 12 preproprotein; disintegrin and metalloproteinase domain-containing protein 12", "tax_id": 10090, "disease": "osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:11489); (R-MMU-8941237)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10788519;11127814;21750661;25428506;34428180;35610640;35946473;36545255;36866761;37495855;7566181;9622634", "class_list": "", "function": "A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelialmesenchymal transition., [RefSeq, PubMed]; ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy., [RefSeq, PubMed]; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors., [UniProtKB]; MicroRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery., [RefSeq, PubMed]; Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "F8VQN4", "ec_number_list": [ { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.86", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q61824-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46662-1", "uniprot_id": [ { "id": "MERL_MOUSE", "url": "https://www.uniprot.org/uniprot/P46662", "type": "external" } ], "mass": 69776.0, "length": 596, "protein_name": "Merlin", "gene_name": "Nf2", "organism": "Mouse", "refseq_name": "merlin isoform 1", "refseq_ac": [ { "id": "NP_001239179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239179", "type": "external" } ], "gene_names_uniprotkb": "Nf2; Nf-2", "gene_names_refseq": "Nf2; merlin", "protein_names_uniprotkb": "Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomin", "protein_names_refseq": "merlin isoform 1; moesin-ezrin-radixin-like protein; neurofibromatosis 2; schwannomin", "tax_id": 10090, "disease": "vestibular schwannomatosis (Disease Ontology:DOID:0111252); otitis media (Disease Ontology:DOID:10754); coloboma (Disease Ontology:DOID:12270); acoustic neuroma (Disease Ontology:DOID:12689); epilepsy (Disease Ontology:DOID:1826); neurilemmoma (Disease Ontology:DOID:3192); meningioma (Disease Ontology:DOID:3565); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18016); (R-MMU-2029482); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "15913605;20181838;21085651;21750661;25428506;30084848;32422606;33414453;34428180;35820727;7981675;8012352;8088840", "class_list": "", "function": "Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR03", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0008013 beta-catenin binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0035330 regulation of hippo signaling;GO:1902115 regulation of organelle assembly;GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P46662-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGM1-1", "uniprot_id": [ { "id": "AGRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGM1", "type": "external" } ], "mass": 169863.0, "length": 1561, "protein_name": "Adhesion G protein-coupled receptor B2", "gene_name": "Adgrb2", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor B2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001186625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186625", "type": "external" } ], "gene_names_uniprotkb": "Adgrb2; Bai2", "gene_names_refseq": "Adgrb2; Bai2", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor B2; Brain-specific angiogenesis inhibitor 2", "protein_names_refseq": "G protein-coupled receptor brain-specific angiogenesis inhibitor 1; adhesion G protein-coupled receptor B2 isoform 2 precursor; brain-specific angiogenesis inhibitor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230775)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12218411;16412436;18034455;20367554;21110148;21750661;28891236;28894906;30899004;31219806", "class_list": "", "function": "BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway, [RefSeq, PubMed]; Orphan G protein-coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G protein GNAZ. Involved in angiogenesis inhibition (PubMed:12218411)., [UniProtKB, PubMed, UniProtKB]; Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia., [RefSeq, PubMed]; Surface expression of Bai2 R619W is markedly reduced relative to wild-type Bai2., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B1ASB7;B1ASB8;B2FDE3;Q3TYC8;Q3UN11;Q3UNE2;Q6PGN0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0051965 positive regulation of synapse assembly;GO:0007422 peripheral nervous system development;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8CGM1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V1L4-1", "uniprot_id": [ { "id": "5NTC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V1L4", "type": "external" } ], "mass": 64809.0, "length": 560, "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "Nt5c2", "organism": "Mouse", "refseq_name": "cytosolic purine 5'-nucleotidase isoform 1", "refseq_ac": [ { "id": "NP_001157835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157835", "type": "external" } ], "gene_names_uniprotkb": "Nt5c2", "gene_names_refseq": "2010002I23Rik; CnII; Gm9751; Gmp; Nt5b; Nt5c2; Pnt5; cN-II", "protein_names_uniprotkb": "Cytosolic purine 5'-nucleotidase; 2.7.1.77; 3.1.3.5; 3.1.3.99; Cytosolic nucleoside phosphotransferase 5'N", "protein_names_refseq": "cytosolic 5'-nucleotidase II; cytosolic nucleoside phosphotransferase 5'N; cytosolic purine 5'-nucleotidase isoform 1; cytosolic purine 5'-nucleotidase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 45 (Disease Ontology:DOID:0110797); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:76952); (R-MMU-2161541); (R-MMU-74259); (R-MMU-9755088)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;25428506;28325731;30084848;30779550;34428180;40885482", "class_list": "", "function": "Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P223;Q8BZ43;Q9D8G6", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0050146 nucleoside phosphotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050689 negative regulation of defense response to virus by host;GO:0046054 dGMP metabolic process;GO:0046037 GMP metabolic process;GO:0046040 IMP metabolic process;GO:0046085 adenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3V1L4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88566-1", "uniprot_id": [ { "id": "AXIN2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88566", "type": "external" } ], "mass": 92906.0, "length": 840, "protein_name": "Axin-2", "gene_name": "Axin2", "organism": "Mouse", "refseq_name": "axin-2", "refseq_ac": [ { "id": "NP_056547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056547", "type": "external" } ], "gene_names_uniprotkb": "Axin2", "gene_names_refseq": "Axi1; Axil; Axin2; Conductin", "protein_names_uniprotkb": "Axin-2; Axil; Axin-like protein; Axis inhibition protein 2; Conductin", "protein_names_refseq": "axin-2; axin-like protein; axis inhibition protein 2", "tax_id": 10090, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); orofacial cleft (Disease Ontology:DOID:0050567); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colon adenoma (Disease Ontology:DOID:0050912); colorectal carcinoma (Disease Ontology:DOID:0080199); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); craniosynostosis (Disease Ontology:DOID:2340); endometrial adenocarcinoma (Disease Ontology:DOID:2870); gallbladder cancer (Disease Ontology:DOID:3121); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (mmu:12006); (R-MMU-201681); (R-MMU-4641257); (R-MMU-5689880)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12183362;21750661;23562159;27713059;34428180;36210013;9554852", "class_list": "", "function": "Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFZ9;Q9QXJ6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation;GO:0048255 mRNA stabilization;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88566-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97346-1", "uniprot_id": [ { "id": "NXN_MOUSE", "url": "https://www.uniprot.org/uniprot/P97346", "type": "external" } ], "mass": 48344.0, "length": 435, "protein_name": "Nucleoredoxin", "gene_name": "Nxn", "organism": "Mouse", "refseq_name": "nucleoredoxin", "refseq_ac": [ { "id": "NP_032776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032776", "type": "external" } ], "gene_names_uniprotkb": "Nxn; Gn25", "gene_names_refseq": "Nxn; l11Jus13", "protein_names_uniprotkb": "Nucleoredoxin; 1.8.1.8; Protein Red-1", "protein_names_refseq": "nucleoredoxin; protein Red-1", "tax_id": 10090, "disease": "autosomal recessive Robinow syndrome 2 (Disease Ontology:DOID:0060974)", "pathway": " (mmu:18230)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10903915;15670764;16604061;16764867;20970343;29187734;34428180;9119370", "class_list": "", "function": "Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5H8T6;Q5H8U0;Q99KF3", "ec_number_list": [ { "id": "1.8.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.8", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0072359 circulatory system development;GO:0001701 in utero embryonic development;GO:0030154 cell differentiation;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97346-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC56-1", "uniprot_id": [ { "id": "RNF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC56", "type": "external" } ], "mass": 55517.0, "length": 488, "protein_name": "E3 ubiquitin-protein ligase RNF8", "gene_name": "Rnf8", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF8", "refseq_ac": [ { "id": "NP_067394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067394", "type": "external" } ], "gene_names_uniprotkb": "Rnf8", "gene_names_refseq": "3830404E21Rik; AIP37; Rnf8; laXp180", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF8; 2.3.2.27; AIP37; ActA-interacting protein 37; LaXp180; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8", "protein_names_refseq": "ActA binding protein 2; E3 ubiquitin-protein ligase RNF8; RING-type E3 ubiquitin transferase RNF8; actA-interacting protein 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:58230); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "11207567;19124460;20080757;20153262;21706008;21750661;21857671;22101936;22266820;24953653;25428506;28552346;31219806;32597970;34225362;35622272;37697435", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Promotes the recruitment of NBN to DNA damage sites by catalyzing 'Lys-6'-linked ubiquitination of NBN. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis (PubMed:20153262, PubMed:28552346). At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed]; Neuroprotective Effect of E3 Ubiquitin Ligase RNF8 Against Ischemic Stroke via HDAC2 Stability Reduction and Reelin-Dependent GSK3beta Inhibition. Erratum:[Mol Neurobiol. 2022 Aug;59(8):4791-4792. doi: 10.1007/s12035-022-02938-9. PMID: 35789977], [RefSeq, PubMed]; RNF8 induces autophagy and reduces inflammation by promoting AKT degradation via ubiquitination in ulcerative colitis mice., [RefSeq, PubMed]; RNF8 is not required for histone-to-protamine exchange in spermiogenesisdagger., [RefSeq, PubMed]; RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells., [RefSeq, PubMed]; Subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJV7;Q9JK13", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VC56-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZN5-1", "uniprot_id": [ { "id": "ACAD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZN5", "type": "external" } ], "mass": 68722.0, "length": 625, "protein_name": "Complex I assembly factor ACAD9, mitochondrial", "gene_name": "Acad9", "organism": "Mouse", "refseq_name": "complex I assembly factor ACAD9, mitochondrial", "refseq_ac": [ { "id": "NP_766266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766266", "type": "external" } ], "gene_names_uniprotkb": "Acad9", "gene_names_refseq": "2600017P15Rik; 4732402K02; Acad9; C630012L17Rik; NPD002", "protein_names_uniprotkb": "Complex I assembly factor ACAD9, mitochondrial; 1.3.8.7; 1.3.8.8; ACAD-9; Acyl-CoA dehydrogenase family member 9", "protein_names_refseq": "acyl-CoA dehydrogenase family member 9, mitochondrial; complex I assembly factor ACAD9, mitochondrial; very-long-chain acyl-CoA dehydrogenase VLCAD homolog", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 20 (Disease Ontology:DOID:0112072)", "pathway": " (mmu:229211); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16199475;21183079;21750661;23576753;23806337;25428506;26740625;30084848;34428180;37507081", "class_list": "", "function": "Together with NDUFAF1 and ECSIT, forms part of the mitochondrial complex I (MCIA),which is required for the biogenesis of respiratory Complex I (CI) and is therefore crucial for the activation of the oxidative phosphorylation system. ECSIT binding triggers a large conformational change, switching ACAD9 from a fatty acid oxidation (FAO) enzyme to a CI assembly factor. The function in CI assembly is independent of the fatty acid oxidation (FAO) activity of the protein. As FAO enzyme, it catalyzes the first step in mitochondrial FAO, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Its preferred substrates are both saturated and unsaturated long-chain acyl-CoA substrates, with optimum activity toward the latter. In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACADV and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed. It differs significantly from ACADVL in the use of polyunsaturated substrates in vitro, especially docosahexaenoic acid (which is not primarily used for energy but mainly beta-oxidized in the peroxisomes)., [UniProtKB, UniProtKB]; We conclude that disturbed mitochondrial bioenergetics in BAT is a critical contributing factor for the cold sensitivity in VLCAD deficiency, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULL9;Q8BK76;Q8C0B5", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0030674 protein-macromolecule adaptor activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0031966 mitochondrial membrane;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0051791 medium-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8JZN5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZZ7-1", "uniprot_id": [ { "id": "AGRL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZZ7", "type": "external" } ], "mass": 166577.0, "length": 1487, "protein_name": "Adhesion G protein-coupled receptor L2", "gene_name": "Adgrl2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adgrl2; Kiaa0786; Lphn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L2; CIRL-2; Calcium-independent alpha-latrotoxin receptor 2; Latrophilin-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:99633)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19349973;19656770;21183079;21750661;24273166;25428506;28972101;30779550;30792275;30899004;33300544;34428180;37828378", "class_list": "", "function": "Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity (PubMed:28972101, PubMed:30792275). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G protein-coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity (PubMed:24273166, PubMed:30792275). Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus (PubMed:28972101, PubMed:30792275). Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (PubMed:30792275)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9Q6C7;Q8BM90", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030246 carbohydrate binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0097060 synaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0050808 synapse organization;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q8JZZ7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZR0-1", "uniprot_id": [ { "id": "ACSL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZR0", "type": "external" } ], "mass": 76206.0, "length": 683, "protein_name": "Long-chain-fatty-acid--CoA ligase 5", "gene_name": "Acsl5", "organism": "Mouse", "refseq_name": "long-chain-fatty-acid--CoA ligase 5", "refseq_ac": [ { "id": "NP_082252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082252", "type": "external" } ], "gene_names_uniprotkb": "Acsl5; Facl5", "gene_names_refseq": "1700030F05Rik; ACS2; ACS5; Acsl5; Facl5", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 5; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; LACS 5; Long-chain acyl-CoA synthetase 5", "protein_names_refseq": "LACS 5; arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 5; long-chain acyl-CoA synthetase 5; long-chain-fatty-acid--CoA ligase 5", "tax_id": 10090, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (mmu:433256); (R-MMU-75876)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15051725;21750661;23576753;26740625;30084848;31219806;34428180;36208627;37453647;37507081;38499083", "class_list": "", "function": "Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth Erratum:[J Biol Chem. 2005 Mar 25;280(12):12064], [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL (By similarity). May have a role in the survival of glioma cells (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity)., [UniProtKB, UniProtKB]; Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation., [RefSeq, PubMed]; Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates postprandial GLP-1 & PYY secretion, reduces food intake, and protects against diet-induced obesity., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity;GO:0090434 oleoyl-CoA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0015908 fatty acid transport;GO:2001236 regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8JZR0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8Q8-1", "uniprot_id": [ { "id": "AGRF5_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8Q8", "type": "external" } ], "mass": 149387.0, "length": 1348, "protein_name": "Adhesion G protein-coupled receptor F5", "gene_name": "Adgrf5", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor F5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001074647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074647", "type": "external" } ], "gene_names_uniprotkb": "Adgrf5; Gpr116", "gene_names_refseq": "8430401C09Rik; 9330185D23; Adgrf5; Gpr116; mKIAA0758", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F5; G protein-coupled hepta-helical receptor Ig-hepta; G protein-coupled receptor 116; Ig-Hepta", "protein_names_refseq": "G protein coupled receptor Gpr116; G protein-coupled receptor 116; G-protein coupled hepta-helical receptor Ig-hepta; Ig-Hepta; adhesion G protein-coupled receptor F5 isoform 1 precursor; probable G-protein coupled receptor 116", "tax_id": 10090, "disease": "", "pathway": " (mmu:224792); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22837050;22971422;23590306;23684610;23922714;26394398;28154189;28570277;30899004;31219806;33004624;34016966;34428180;36073784;37266730;38228886", "class_list": "", "function": "Adhesion G protein-coupled receptor (PubMed:23590306, PubMed:23684610, PubMed:23922714, PubMed:28570277). In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis (PubMed:23590306, PubMed:23684610, PubMed:23922714, PubMed:28570277). Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation (PubMed:28570277). In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump (PubMed:33004624). As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue (PubMed:22971422, PubMed:34016966)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Adhesion G protein-coupled receptor. In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis. Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation. In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump. As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue., [UniProtKB, UniProtKB]; GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc[-]/GSH/GPX4., [RefSeq, PubMed]; The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 30, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0031410 cytoplasmic vesicle;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043129 surfactant homeostasis;GO:0019216 regulation of lipid metabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "G5E8Q8-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08509-1", "uniprot_id": [ { "id": "EPS8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08509", "type": "external" } ], "mass": 91737.0, "length": 821, "protein_name": "Epidermal growth factor receptor kinase substrate 8", "gene_name": "Eps8", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor kinase substrate 8 isoform 2", "refseq_ac": [ { "id": "NP_001258516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258516", "type": "external" } ], "gene_names_uniprotkb": "Eps8", "gene_names_refseq": "Eps8", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8", "protein_names_refseq": "epidermal growth factor receptor kinase substrate 8 isoform 2; epidermal growth factor receptor kinase substrate 8", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 102 (Disease Ontology:DOID:0110463)", "pathway": " (mmu:13860)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10499589;11524436;12127568;15558031;15592455;16452087;17115031;19144319;19528316;19564905;20532239;21183079;21236676;21750661;21835647;23314863;23918390;24741995;28214294;30084848;34428180;34887587;36395759;7537362;8404850;9303002", "class_list": "", "function": "Chlamydia repurposes the actin-binding protein EPS8 to disassemble epithelial tight junctions and promote infection., [RefSeq, PubMed]; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM41", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0070358 actin polymerization-dependent cell motility;GO:0008344 adult locomotory behavior;GO:0048149 behavioral response to ethanol;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q08509-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XG73-1", "uniprot_id": [ { "id": "ACBD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XG73", "type": "external" } ], "mass": 56614.0, "length": 508, "protein_name": "Acyl-CoA-binding domain-containing protein 5", "gene_name": "Acbd5", "organism": "Mouse", "refseq_name": "acyl-CoA-binding domain-containing protein 5 isoform d", "refseq_ac": [ { "id": "NP_001095906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095906", "type": "external" } ], "gene_names_uniprotkb": "Acbd5", "gene_names_refseq": "1300014E15Rik; Acbd5", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 5", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 5 isoform d; acyl-CoA-binding domain-containing protein 5", "tax_id": 10090, "disease": "retinal dystrophy with leukodystrophy (Disease Ontology:DOID:0080946); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (mmu:74159); (R-MMU-390918); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9603798)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17768142;21183079;21750661;23576753;27802388;33244184;34428180;37453647", "class_list": "", "function": "Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQX9;A2AQY0;Q6P7V7;Q7TSC2;Q8BKU6;Q8CI99;Q9CW41", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0000425 pexophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5XG73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIF0-1", "uniprot_id": [ { "id": "ANM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIF0", "type": "external" } ], "mass": 42436.0, "length": 371, "protein_name": "Protein arginine N-methyltransferase 1", "gene_name": "Prmt1", "organism": "Mouse", "refseq_name": "protein arginine N-methyltransferase 1 isoform 2", "refseq_ac": [ { "id": "NP_001239405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239405", "type": "external" } ], "gene_names_uniprotkb": "Prmt1; Hrmt1l2; Mrmt1", "gene_names_refseq": "6720434D09Rik; Hrmt1l2; Mrmt1; Prmt1", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 1; 2.1.1.319; Histone-arginine N-methyltransferase PRMT1", "protein_names_refseq": "arginine N-methyltransferase 1; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; histone-arginine N-methyltransferase PRMT1; protein arginine N-methyltransferase 1 isoform 2", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:15469); (R-MMU-3214858); (R-MMU-8936459); (R-MMU-9009391); (R-MMU-9018519)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10848611;11835310;15327772;19858291;21540332;21750661;22872234;22872859;23806337;25153642;25428506;28883095;30321814;31219806;34428180;38006878;38460517;38605214;38970508;40997131", "class_list": "", "function": "Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP, MAP3K5/ASK1, MICU1 and NPRL2 (PubMed:15327772, PubMed:19858291, PubMed:38006878). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-3' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway (By similarity). Methylates RBM15, promoting ubiquitination and degradation of RBM15 (By similarity). Methylates MRE11 and TP53BP1, promoting the DNA damage response (By similarity). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:19858291). Methylates MAP3K5/ASK1 at 'Arg-85' and 'Arg-87' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (By similarity). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (By similarity). Plays a role in regulating alternative splicing in the heart (PubMed:30321814). Methylates NPRL2 at 'Arg-78' leading to inhibition of its GTPase activator activity and then the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions (PubMed:38006878). Methylates the C-terminus of DSP, promoting its phosphorylation by GSK3B and subsequent recruitment to desmosome cell-cell junctions (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; EGR3 reduces podocyte inflammatory damage in obesity related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway., [RefSeq, PubMed]; LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis., [RefSeq, PubMed]; PRMT1 promotes pancreatic cancer development and resistance to chemotherapy., [RefSeq, PubMed]; Type I protein arginine methyltransferase (PRMT) activity produces asymmetric dimethylation of the terminal guanidinonitrogen of arginines in substrate proteins, particularly glycine and arginine-rich (GAR) segments of proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LS4", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0008170 N-methyltransferase activity;GO:0008276 protein methyltransferase activity;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9JIF0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZI0-1", "uniprot_id": [ { "id": "AF1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZI0", "type": "external" } ], "mass": 86638.0, "length": 768, "protein_name": "Actin filament-associated protein 1-like 1", "gene_name": "Afap1l1", "organism": "Mouse", "refseq_name": "actin filament-associated protein 1-like 1", "refseq_ac": [ { "id": "NP_849259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849259", "type": "external" } ], "gene_names_uniprotkb": "Afap1l1", "gene_names_refseq": "Afap1l1", "protein_names_uniprotkb": "Actin filament-associated protein 1-like 1; AFAP1-like protein 1", "protein_names_refseq": "AFAP1-like protein 1; actin filament-associated protein 1-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106877)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15345747;21183079;21750661", "class_list": "", "function": "May be involved in podosome and invadosome formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKB8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0002102 podosome;GO:0001725 stress fiber;GO:0042995 cell projection;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BZI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08501-1", "uniprot_id": [ { "id": "PRLR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08501", "type": "external" } ], "mass": 68241.0, "length": 608, "protein_name": "Prolactin receptor", "gene_name": "Prlr", "organism": "Mouse", "refseq_name": "prolactin receptor isoform 3 precursor", "refseq_ac": [ { "id": "NP_001240711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240711", "type": "external" } ], "gene_names_uniprotkb": "Prlr; PRLR", "gene_names_refseq": "Pr-1; Pr-3; Prlr-rs1; Prlr", "protein_names_uniprotkb": "Prolactin receptor; PRL-R", "protein_names_refseq": "PRL-R; prolactin receptor isoform 3 precursor; prolactin receptor related sequence 1", "tax_id": 10090, "disease": "familial medullary thyroid carcinoma (Disease Ontology:DOID:0050547); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (mmu:19116); (R-MMU-1170546); (R-MMU-982772)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17675186;21750661;25428506;2725531;8262385;8319571", "class_list": "", "function": "This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P15212;P15213;Q62099", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding", "go_cellular_component": "GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity;GO:0008284 positive regulation of cell population proliferation;GO:0030155 regulation of cell adhesion;GO:0043066 negative regulation of apoptotic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q08501-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48193-1", "uniprot_id": [ { "id": "EPB41_MOUSE", "url": "https://www.uniprot.org/uniprot/P48193", "type": "external" } ], "mass": 95911.0, "length": 858, "protein_name": "Protein 4.1", "gene_name": "Epb41", "organism": "Mouse", "refseq_name": "protein 4.1 isoform 2", "refseq_ac": [ { "id": "NP_001122078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122078", "type": "external" } ], "gene_names_uniprotkb": "Epb41; Epb4.1; Kiaa4056", "gene_names_refseq": "4.1R; D4Ertd442e; Elp-1; Elp1; Epb4.1; Epb41; mKIAA4056", "protein_names_uniprotkb": "Protein 4.1; 4.1R; Band 4.1; Erythrocyte membrane protein band 4.1; P4.1", "protein_names_refseq": "P4.1; Protein 4.1R; band 4.1; erythrocyte protein band 4.1; protein 4.1 isoform 2; protein 4.1", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); hereditary elliptocytosis (Disease Ontology:DOID:2373)", "pathway": " (mmu:269587); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11432737;17242355;17947660;19144319;21183079;21750661;23460639;31219806;33385415;34364872;34428180;34717920;35822049;37507081;40885482;8429050", "class_list": "", "function": "Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation., [RefSeq, PubMed]; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase., [UniProtKB, UniProtKB]; Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid., [RefSeq, PubMed]; The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A843;Q5DTQ8;Q68FF1;Q6NVF5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0051219 phosphoprotein binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051301 cell division;GO:0051924 regulation of calcium ion transport;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P48193-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q394-1", "uniprot_id": [ { "id": "AKP13_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q394", "type": "external" } ], "mass": 303976.0, "length": 2776, "protein_name": "A-kinase anchor protein 13", "gene_name": "Akap13", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 13", "refseq_ac": [ { "id": "NP_083608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083608", "type": "external" } ], "gene_names_uniprotkb": "Akap13; Brx", "gene_names_refseq": "1700026G02Rik; 5730522G15Rik; 5830460E08Rik; AKAP-13; AKAP-Lbc; Akap13; BRX; Ht31; LBC; PROTO-LBC; PROTO-LB", "protein_names_uniprotkb": "A-kinase anchor protein 13; AKAP-13; AKAP-Lbc", "protein_names_refseq": "A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; type II cAMP-dependent protein kinase anchoring protein Ht31", "tax_id": 10090, "disease": "", "pathway": " (mmu:75547); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "16469733;17242355;17537920;19144319;20139090;21102438;21183079;21750661;23090968;23658642;24161911;25428506;25605945;25892096;29653158;34428180;40885482", "class_list": "", "function": "Akap13 haploinsufficiency led to sex-dependent, compulsive-like behavioral changes in a murine model. Interestingly, Akap13 haploinsufficiency also led to a sex-dependent increase in body weight., [RefSeq, PubMed]; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members (By similarity). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G protein-coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (By similarity). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (By similarity). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (PubMed:24161911). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (By similarity). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (PubMed:20139090). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:24161911). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:17537920, PubMed:24161911). Plays a role in osteogenesis (PubMed:25892096)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEI5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0043410 positive regulation of MAPK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043406 positive regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9Q394-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1F4-1", "uniprot_id": [ { "id": "AKTS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1F4", "type": "external" } ], "mass": 27483.0, "length": 257, "protein_name": "Proline-rich AKT1 substrate 1", "gene_name": "Akt1s1", "organism": "Mouse", "refseq_name": "proline-rich AKT1 substrate 1 isoform b", "refseq_ac": [ { "id": "NP_001240849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240849", "type": "external" } ], "gene_names_uniprotkb": "Akt1s1; Pras", "gene_names_refseq": "1110012J22Rik; Akt1s1; Lobel; Lobe; PRAS40", "protein_names_uniprotkb": "Proline-rich AKT1 substrate 1; Proline-rich AKT substrate", "protein_names_refseq": "AKT1 substrate 1 (proline-rich); proline-rich AKT substrate; proline-rich AKT1 substrate 1 isoform b; proline-rich AKT1 substrate 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67605); (R-MMU-165159); (R-MMU-166208); (R-MMU-198323); (R-MMU-3371571)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12524439;14973226;15345747;16397181;17242355;21183079;21750661;24129315;25153642;28294542;29176673;31740404;38311163", "class_list": "", "function": "Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (By similarity). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (By similarity). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (By similarity). May also play a role in nerve growth factor-mediated neuroprotection (PubMed:14973226, PubMed:16397181)., [UniProtKB, UniProtKB, PubMed, PubMed]; Overexpression of SOD1 may affect the PRAS pathway after transient focal cerebral ischemia by reducing the direct oxidative reaction to pPRAS after reperfusion injury, [RefSeq, PubMed]; PRAS phosphorylation and its interaction with pAkt and 14-3-3 might play an important role in neuroprotection mediated by NGF in apoptotic neuronal cell death after transient focal cerebral ischemia, [RefSeq, PubMed]; PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease., [RefSeq, PubMed]; Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis., [RefSeq, PubMed]; The protein product encoded by 1110012J22 gene is proline-rich substrate of Akt which also binds to 14-3-3. A proposed name for this protein is thus PRAS40, for proline-rich substrate of Akt of 40 kDa., [RefSeq, PubMed]; This study, for the first time, links PF4's anti-RNV function to an intracellular signaling molecule PRAS40 and its phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RT52", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0031931 TORC1 complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0006469 negative regulation of protein kinase activity;GO:0031669 cellular response to nutrient levels;GO:0032007 negative regulation of TOR signaling;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D1F4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXG4-1", "uniprot_id": [ { "id": "ACSA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXG4", "type": "external" } ], "mass": 78862.0, "length": 701, "protein_name": "Acetyl-coenzyme A synthetase, cytoplasmic", "gene_name": "Acss2", "organism": "Mouse", "refseq_name": "acetyl-coenzyme A synthetase, cytoplasmic", "refseq_ac": [ { "id": "NP_062785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062785", "type": "external" } ], "gene_names_uniprotkb": "Acss2; Acas2; Acecs1", "gene_names_refseq": "1110017C11Rik; ACAS; ACS; Acas1; Acas2; AceCS1; Acs1; Acss2; aceCS", "protein_names_uniprotkb": "Acetyl-coenzyme A synthetase, cytoplasmic; 6.2.1.-; 6.2.1.17; 6.2.1.1; ACS; AceCS1; AceCS; Acetate--CoA ligase; Acetyl-CoA synthetase 1; Acetyl-CoA synthetase; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Lactyl-CoA synthetase; Propionyl-CoA synthetase", "protein_names_refseq": "acetate--CoA ligase; acetyl-CoA synthetase 1; acetyl-Coenzyme A synthetase 1 (AMP forming); acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-Coenzyme A synthetase 2 (AMP forming); acetyl-coenzyme A synthetase, cytoplasmic; acyl-activating enzyme; propionate--CoA ligase", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); morbid obesity (Disease Ontology:DOID:11981); alcohol use disorder (Disease Ontology:DOID:1574); lymphangioleiomyomatosis (Disease Ontology:DOID:3319)", "pathway": " (mmu:60525); (R-MMU-2151201); (R-MMU-71384)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11150295;12049778;16790548;17114649;17242355;18630941;21183079;21750661;27180971;28552616;28562591;31219806;34428180;37507081", "class_list": "", "function": "Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548, PubMed:28562591). Acetate is the preferred substrate but can also utilize propionate with a much lower affinity (PubMed:11150295). Catalyzes the conversion of lactate into lactoyl-CoA (By similarity). Does not catalyze the conversion of butyrate or crotonate to their corresponding acyl-CoAs (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (By similarity). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (By similarity). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (By similarity). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (PubMed:28562591). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (PubMed:28562591)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK97", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0003987 acetate-CoA ligase activity;GO:0050218 propionate-CoA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008610 lipid biosynthetic process;GO:0006068 ethanol catabolic process;GO:0006085 acetyl-CoA biosynthetic process;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QXG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UGP8-1", "uniprot_id": [ { "id": "AG10B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UGP8", "type": "external" } ], "mass": 55465.0, "length": 474, "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "Alg10b; Alg10", "organism": "Mouse", "refseq_name": "dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "refseq_ac": [ { "id": "NP_001028613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028613", "type": "external" } ], "gene_names_uniprotkb": "Alg10b; Alg10; Alg10b", "gene_names_refseq": "Alg10b; Alg10; Deaf1; Gm917; nse5", "protein_names_uniprotkb": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; 2.4.1.256; Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10-B; Asparagine-linked glycosylation protein 10 homolog B", "protein_names_refseq": "alpha-1,2-glucosyltransferase ALG10-A; alpha-2-glucosyltransferase ALG10-B; asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase); asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase); asparagine-linked glycosylation protein 10 homolog B; dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; potassium channel regulator 1; putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; putative alpha-1,2-glucosyltransferase ALG10-B", "tax_id": 10090, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); long QT syndrome 2 (Disease Ontology:DOID:0110645)", "pathway": " (mmu:380959)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;21952136;24303013;25428507;31219806;33649389;34428180;37828378", "class_list": "glycogene;glycosyltransferase", "function": "A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLS4", "ec_number_list": [ { "id": "2.4.1.256", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.256", "type": "external" } ], "go_molecular_function": "GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 41, "hit_score": 0.9, "record_id": "Q3UGP8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70180-1", "uniprot_id": [ { "id": "ANPRC_MOUSE", "url": "https://www.uniprot.org/uniprot/P70180", "type": "external" } ], "mass": 59808.0, "length": 536, "protein_name": "Atrial natriuretic peptide receptor 3", "gene_name": "Npr3", "organism": "Mouse", "refseq_name": "atrial natriuretic peptide receptor 3 isoform a precursor", "refseq_ac": [ { "id": "NP_032754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032754", "type": "external" } ], "gene_names_uniprotkb": "Npr3", "gene_names_refseq": "ANP-C; ANPR-C; EF-2; NPR-C; Npr3; lgj; stri", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 3; ANP-C; ANPR-C; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; EF-2; NPR-C", "protein_names_refseq": "Nppc receptor; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor 3 isoform a precursor; atrial natriuretic peptide receptor type C; longjohn; strigosus", "tax_id": 10090, "disease": "bone disease (Disease Ontology:DOID:0080001); hypertension (Disease Ontology:DOID:10763); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:18162)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10377427;10468599;14523025;17951249;19244276;21750661;8620881;9032278", "class_list": "", "function": "Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP (PubMed:10377427, PubMed:17951249). May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects (PubMed:10377427, PubMed:17951249). Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (PubMed:14523025, PubMed:19244276)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X9E5;P97804;Q9R025;Q9R027;Q9R028", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031404 chloride ion binding;GO:0042562 hormone binding;GO:0017046 peptide hormone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006182 cGMP biosynthetic process;GO:0007165 signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70180-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9J9-1", "uniprot_id": [ { "id": "ANO6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9J9", "type": "external" } ], "mass": 106255.0, "length": 911, "protein_name": "Anoctamin-6", "gene_name": "Ano6", "organism": "Mouse", "refseq_name": "anoctamin-6 isoform 1", "refseq_ac": [ { "id": "NP_001240742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240742", "type": "external" } ], "gene_names_uniprotkb": "Ano6; Tmem16f", "gene_names_refseq": "2900059G15Rik; Ano6; F730003B03Rik; Tmem16f", "protein_names_uniprotkb": "Anoctamin-6; SCAN channel; Small-conductance calcium-activated nonselective cation channel; Transmembrane protein 16F", "protein_names_refseq": "SCAN channel; anoctamin-6 isoform 1; small-conductance calcium-activated nonselective cation channel; transmembrane protein 16F", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); Scott syndrome (Disease Ontology:DOID:0111052); ankylosing spondylitis (Disease Ontology:DOID:7147)", "pathway": " (mmu:105722); (R-MMU-2672351); (R-MMU-6798695); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;18729231;19059364;19656770;20056604;21107324;21750661;21908539;22075693;22302790;22936354;23021219;23532839;25428506;29187734;30084848;30785399;31015464;31219806;34428180;35820727;39136057;39495104;39627609", "class_list": "", "function": "Data show the expression of Tmem16f during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems., [RefSeq, PubMed]; During mouse cephalic development: detected in subventricular zone and differentiating fields, in rostral spinal cord motor neuron area, stria vascularis,in submandibular autonomic ganglia, in palate, tooth and tongue, and in osteoblasts and chondrocytes, [RefSeq, PubMed]; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes (PubMed:21107324, PubMed:21908539, PubMed:22936354, PubMed:23021219, PubMed:23532839, PubMed:30785399, PubMed:31015464, PubMed:39495104). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (PubMed:22936354, PubMed:23021219). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (PubMed:23021219)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TMEM16F Expressed in Kupffer Cells Regulates Liver Inflammation and Metabolism to Protect Against Listeria Monocytogenes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 32, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8C242", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005227 calcium-activated cation channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0034707 chloride channel complex;GO:0097060 synaptic membrane;GO:0098981 cholinergic synapse", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0090026 positive regulation of monocyte chemotaxis;GO:0007596 blood coagulation;GO:0045332 phospholipid translocation;GO:0030501 positive regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q6P9J9-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01341-1", "uniprot_id": [ { "id": "ADCY6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01341", "type": "external" } ], "mass": 130319.0, "length": 1165, "protein_name": "Adenylate cyclase type 6", "gene_name": "Adcy6", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adcy6", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate cyclase type 6; 4.6.1.1; AC6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase", "protein_names_refseq": "", "tax_id": 10090, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (mmu:11512); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-400042); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;1332848;1379717;17567809;18071070;20173027;20359598;20371630;20466003;20864687;21183079;21670265;21750661;23753526;24158982;24277577;24363043;24854272;31219806;34428180", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:18071070, PubMed:24363043). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:18071070). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption (PubMed:20466003, PubMed:20864687). Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion (PubMed:24854272). Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (PubMed:23753526). Signaling mediates cAMP-dependent activation of protein kinase PKA and promotes increased phosphorylation of various proteins, including AKT (PubMed:18071070, PubMed:23753526). Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility (PubMed:18071070). May contribute to normal heart function (PubMed:18071070, PubMed:20359598). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (By similarity). Contributes to bone cell responses to mechanical stimuli (PubMed:20371630, PubMed:24277577)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9890, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q01341-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58742-1", "uniprot_id": [ { "id": "AAAS_MOUSE", "url": "https://www.uniprot.org/uniprot/P58742", "type": "external" } ], "mass": 59431.0, "length": 546, "protein_name": "Aladin", "gene_name": "Aaas", "organism": "Mouse", "refseq_name": "aladin", "refseq_ac": [ { "id": "NP_700465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700465", "type": "external" } ], "gene_names_uniprotkb": "Aaas", "gene_names_refseq": "AAA; ADRACALA; Aaas; D030041N15Rik; GL003", "protein_names_uniprotkb": "Aladin; Adracalin", "protein_names_refseq": "adracalin; aladin", "tax_id": 10090, "disease": "triple-A syndrome (Disease Ontology:DOID:0050602); achalasia (Disease Ontology:DOID:9164)", "pathway": " (mmu:223921); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-8980692)", "pathway_count": 19, "publication_count": 12, "publication_id_list": "19131326;21183079;21750661;25428506;25605945;26495903;27754849;29187734;30084848;30779550;31219806;34428180", "class_list": "", "function": "Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544M6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0006979 response to oxidative stress;GO:0007612 learning;GO:0009566 fertilization;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P58742-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KI0-1", "uniprot_id": [ { "id": "ACON_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KI0", "type": "external" } ], "mass": 85464.0, "length": 780, "protein_name": "Aconitate hydratase, mitochondrial", "gene_name": "Aco2", "organism": "Mouse", "refseq_name": "aconitate hydratase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_542364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542364", "type": "external" } ], "gene_names_uniprotkb": "Aco2", "gene_names_refseq": "Aco-2; Aco2; Aco3; D10Wsu183e; Irp1", "protein_names_uniprotkb": "Aconitate hydratase, mitochondrial; 4.2.1.3; Aconitase; Citrate hydro-lyase", "protein_names_refseq": "aconitate hydratase, mitochondrial precursor; aconitate hydratase, mitochondrial; citrate hydro-lyase", "tax_id": 10090, "disease": "infantile cerebellar-retinal degeneration (Disease Ontology:DOID:0050883); optic atrophy 9 (Disease Ontology:DOID:0111442); neurodegenerative disease (Disease Ontology:DOID:1289); optic nerve disease (Disease Ontology:DOID:1891); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:11429); (R-MMU-71403); (R-MMU-9837999); (R-MMU-9854311)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10657609;21183079;21750661;23576753;23806337;25428506;26495903;28011936;31599954;32839225;34428180;34887587;35820727;35984892;36288343;37453647;37507081;37828378;38007539;39627609;39927985", "class_list": "", "function": "ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDK9;Q3ULG9;Q3UNH7;Q505P4", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0003994 aconitate hydratase activity;GO:0005506 iron ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q99KI0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100100000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0J2-1", "uniprot_id": [ { "id": "A16L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0J2", "type": "external" } ], "mass": 68172.0, "length": 607, "protein_name": "Autophagy-related protein 16-1", "gene_name": "Atg16l1", "organism": "Mouse", "refseq_name": "autophagy-related protein 16-1 isoform 1", "refseq_ac": [ { "id": "NP_001192320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192320", "type": "external" } ], "gene_names_uniprotkb": "Atg16l1; Apg16l", "gene_names_refseq": "1500009K01Rik; Apg16l; Atg16l1; Atg16l; WDR30", "protein_names_uniprotkb": "Autophagy-related protein 16-1; APG16-like 1", "protein_names_refseq": "APG16-like 1; Atg16L1 gamma; autophagy-related 16-like 1 gamma; autophagy-related protein 16-1 isoform 1; autophagy-related protein 16-1", "tax_id": 10090, "disease": "inflammatory bowel disease 10 (Disease Ontology:DOID:0110885)", "pathway": " (mmu:77040); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "12665549;18321988;18448665;18849966;19898471;19966812;21183079;21750661;22082872;22645316;23262492;23392225;24089209;24238340;24553140;24821797;24954904;28082356;31219806;32960676;33087875;33586810;34428180;34678516;38227290", "class_list": "", "function": "Atg16L complex is a new type of E3-like enzyme that functions as a scaffold for LC3 lipidation by dynamically localizing to the putative source membranes for autophagosome formation., [RefSeq, PubMed]; In conjunction with Apg12-Apg5, Apg16L associates with the autophagic isolation membrane for the duration of autophagosome formation., [RefSeq, PubMed]; Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:12665549, PubMed:18849966, PubMed:19898471, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:33586810). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:33586810). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (By similarity). Thereby, controls the elongation of the nascent autophagosomal membrane (By similarity). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (PubMed:38227290). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (By similarity). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (PubMed:33586810). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:19898471, PubMed:19966812, PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Rab33 modulates autophagosome formation through interaction with Atg16L, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAT7;Q80U97;Q80U98;Q80U99;Q80Y53;Q9DB63", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0039689 negative stranded viral RNA replication;GO:0051607 defense response to virus;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8C0J2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70302-1", "uniprot_id": [ { "id": "CIDEA_MOUSE", "url": "https://www.uniprot.org/uniprot/O70302", "type": "external" } ], "mass": 24669.0, "length": 217, "protein_name": "Lipid transferase CIDEA", "gene_name": "Cidea", "organism": "Mouse", "refseq_name": "lipid transferase CIDEA", "refseq_ac": [ { "id": "NP_031728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031728", "type": "external" } ], "gene_names_uniprotkb": "Cidea", "gene_names_refseq": "Cidea", "protein_names_uniprotkb": "Lipid transferase CIDEA; Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A", "protein_names_refseq": "cell death activator CIDE-A; cell death-inducing DFFA-like effector A; lipid transferase CIDEA", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12683); (R-MMU-8964572)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12910269;15063110;18509062;20810722;22144693;22245780;26609809;26733203;34428180;36477540;9564035", "class_list": "", "function": "A role for Cidea in regulating energy balance and adiposity, [RefSeq, PubMed]; First protein known to directly modulate Ucp1 activity in regulation of thermogenesis and development of obesity and diabetes. Review. Review article, [RefSeq, PubMed]; Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18509062, PubMed:22144693, PubMed:26609809, PubMed:36477540). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18509062, PubMed:22144693, PubMed:26609809). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18509062, PubMed:22144693, PubMed:26609809). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (PubMed:18509062, PubMed:22144693). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (PubMed:22245780). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (PubMed:22245780). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (PubMed:9564035)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9X2", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0070300 phosphatidic acid binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005811 lipid droplet", "go_biological_process": "GO:0070417 cellular response to cold;GO:0001659 temperature homeostasis;GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70302-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHD1-1", "uniprot_id": [ { "id": "AGRB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHD1", "type": "external" } ], "mass": 173297.0, "length": 1582, "protein_name": "Adhesion G protein-coupled receptor B1", "gene_name": "Adgrb1", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor B1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_778156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778156", "type": "external" } ], "gene_names_uniprotkb": "Adgrb1; Bai1", "gene_names_refseq": "Adgrb1; B830018M07Rik; Bai1; mKIAA4089", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1", "protein_names_refseq": "adhesion G protein-coupled receptor B1 isoform 1 precursor; brain-specific angiogenesis inhibitor 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:107831)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11245925;11875720;17960134;20888903;21183079;21245295;21750661;23595754;23615608;23782696;25428506;25751059;26838550;33340495;35114205;35820727;38564333", "class_list": "", "function": "BAI1 is a phosphatidylserine recognition receptor that can directly recruit a Rac-GEF complex to mediate the uptake of apoptotic cells., [RefSeq, PubMed]; BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing., [RefSeq, PubMed]; Expression pattern in brain regions and role as anti-angiogenic factor in mature neuropil, [RefSeq, PubMed]; Inhibits angiogenesis in a CD36-dependent manner., [UniProtKB, UniProtKB]; Inhibits angiogenesis., [UniProtKB, UniProtKB]; LncRNA embryonic stem cells expressed 1 (Lncenc1) is identified as a novel regulator in neuropathic pain by interacting with EZH2 and downregulating the expression of Bai1 in mouse microglia., [RefSeq, PubMed]; Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development., [RefSeq, PubMed]; Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:17960134). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:21245295, PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (PubMed:23615608). Activates the Rho pathway in a G protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (PubMed:25751059). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 2, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 2, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 2, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 7, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH36;Q8CGM0", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0001530 lipopolysaccharide binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007399 nervous system development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q3UHD1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1110000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60823-1", "uniprot_id": [ { "id": "AKT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60823", "type": "external" } ], "mass": 55742.0, "length": 481, "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "Akt2", "organism": "Mouse", "refseq_name": "RAC-beta serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_001103678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103678", "type": "external" } ], "gene_names_uniprotkb": "Akt2", "gene_names_refseq": "2410016A19Rik; Akt2; PKBbeta; PKB", "protein_names_uniprotkb": "RAC-beta serine/threonine-protein kinase; 2.7.11.1; PKB beta; Protein kinase Akt-2; Protein kinase B beta; RAC-PK-beta", "protein_names_refseq": "PKB beta; RAC-PK-beta; RAC-beta serine/threonine-protein kinase; protein kinase Akt-2; protein kinase B, beta; thymoma viral proto-oncogene 2", "tax_id": 10090, "disease": "hypoinsulinemic hypoglycemia with hemihypertrophy (Disease Ontology:DOID:0112263); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); carcinoma (Disease Ontology:DOID:305); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:11652); (R-MMU-1257604); (R-MMU-1358803); (R-MMU-165158); (R-MMU-165159); (R-MMU-165181); (R-MMU-198323); (R-MMU-198693); (R-MMU-199418); (R-MMU-211163); (R-MMU-3769402); (R-MMU-389357); (R-MMU-389513); (R-MMU-392451); (R-MMU-5218920); (R-MMU-5628897); (R-MMU-6804757); (R-MMU-6804758); (R-MMU-6804759); (R-MMU-69202); (R-MMU-69656); (R-MMU-8876198); (R-MMU-8948751); (R-MMU-9607240); (R-MMU-9614399); (R-MMU-9634638); (R-MMU-9755511)", "pathway_count": 27, "publication_count": 28, "publication_id_list": "16792529;17565718;18160256;19139280;20019746;20074525;20189988;21183079;21432781;21620960;21737686;21750661;21907143;21954288;24156551;24670654;26100075;26286748;26866272;27251941;28052965;28102348;28528544;29678907;31270932;31548312;34428180;7566964", "class_list": "", "function": "AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:21954288, PubMed:26286748, PubMed:29678907, PubMed:31548312). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:21954288, PubMed:26286748, PubMed:29678907, PubMed:31548312). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:26286748, PubMed:31548312). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:31548312). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (By similarity). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (PubMed:29678907). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation (PubMed:17565718). In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (PubMed:20019746). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (PubMed:21737686). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (PubMed:21907143). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (PubMed:20074525)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0032000 positive regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q60823-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06649-1", "uniprot_id": [ { "id": "3BP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06649", "type": "external" } ], "mass": 62208.0, "length": 559, "protein_name": "SH3 domain-binding protein 2", "gene_name": "Sh3bp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sh3bp2; 3bp2", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3 domain-binding protein 2; 3BP-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "cherubism 1 (Disease Ontology:DOID:1856)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "12709437;15751964;17242355;21183079;21750661;34428180;35820727;8438166", "class_list": "", "function": "Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06649-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MR0-1", "uniprot_id": [ { "id": "ACL6B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MR0", "type": "external" } ], "mass": 46891.0, "length": 426, "protein_name": "Actin-like protein 6B", "gene_name": "Actl6b", "organism": "Mouse", "refseq_name": "actin-like protein 6B isoform 1", "refseq_ac": [ { "id": "NP_113581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113581", "type": "external" } ], "gene_names_uniprotkb": "Actl6b; Actl6; Arpna; Baf53b", "gene_names_refseq": "Actl6b; Actl6; ArpNa; Baf53b", "protein_names_uniprotkb": "Actin-like protein 6B; 53 kDa BRG1-associated factor B; Actin-related protein Baf53b; ArpN-alpha; ArpNa; BAF53B; BRG1-associated factor 53B", "protein_names_refseq": "53 kDa BRG1-associated factor B; BRG1-associated factor 53B; actin-like 6; actin-like protein 6B isoform 1; actin-like protein 6B; actin-related protein Baf53b; arpN-alpha", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 76 (Disease Ontology:DOID:0112212); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:83766); (R-MMU-3214858); (R-MMU-8939243)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11239002;12368262;12437990;17640523;17920018;21750661;22952240;26601204;31219806", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A88", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99MR0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K371-1", "uniprot_id": [ { "id": "AMOL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K371", "type": "external" } ], "mass": 85278.0, "length": 772, "protein_name": "Angiomotin-like protein 2", "gene_name": "Amotl2", "organism": "Mouse", "refseq_name": "angiomotin-like protein 2", "refseq_ac": [ { "id": "NP_062738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062738", "type": "external" } ], "gene_names_uniprotkb": "Amotl2", "gene_names_refseq": "Amotl2; Lccp; MASCOT; mKIAA0989", "protein_names_uniprotkb": "Angiomotin-like protein 2", "protein_names_refseq": "Leman coiled-coil protein; angiomotin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56332); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12406577;17397395;21183079;21205866;21750661;23525008;24806444;25428506;27802388;28842668;30084848;34323359;34428180;35820727;39195920", "class_list": "", "function": "AMOTL2 restrains transforming growth factor-beta1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation., [RefSeq, PubMed]; Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1., [RefSeq, PubMed]; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (PubMed:24806444). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (By similarity). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (By similarity). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (By similarity). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (By similarity). May play a role in the polarity, proliferation and migration of endothelial cells., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JK80;Q3TPM1;Q7TPE4;Q8BP84;Q8BS08;Q9QUS0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0055037 recycling endosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8K371-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQC1-1", "uniprot_id": [ { "id": "3BHS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQC1", "type": "external" } ], "mass": 41135.0, "length": 369, "protein_name": "3 beta-hydroxysteroid dehydrogenase type 7", "gene_name": "Hsd3b7", "organism": "Mouse", "refseq_name": "3 beta-hydroxysteroid dehydrogenase type 7 isoform a", "refseq_ac": [ { "id": "NP_598704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598704", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b7", "gene_names_refseq": "Hsd3b7", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase type 7; 1.1.1.-; 1.1.1.181; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; C(27) 3-beta-HSD; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase type 7 isoform a; 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; c(27) 3-beta-HSD; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase", "tax_id": 10090, "disease": "congenital bile acid synthesis defect 1 (Disease Ontology:DOID:0111071); intrahepatic cholestasis (Disease Ontology:DOID:1852)", "pathway": " (mmu:101502); (R-MMU-193368); (R-MMU-193775); (R-MMU-193807)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11067870;17601774;21750661;22999953;25428506;31219806;34428180", "class_list": "glycogene", "function": "Catalyzes two reactions required for inversion of the cholesterol 3beta-hydroxyl group to the 3alpha-hydroxyl of bile acids; its stereochemical alteration eliminates cholesterol absorption in the gut and enterohepatic circulation feedback regulation., [RefSeq, PubMed]; Findings indicate that CYP7B1 and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues., [RefSeq, PubMed]; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTR5", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.181", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.181", "type": "external" } ], "go_molecular_function": "GO:0047016 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001558 regulation of cell growth;GO:0035754 B cell chemotaxis;GO:0006694 steroid biosynthetic process;GO:0006707 cholesterol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EQC1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4G5-1", "uniprot_id": [ { "id": "ABLM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4G5", "type": "external" } ], "mass": 96805.0, "length": 861, "protein_name": "Actin-binding LIM protein 1", "gene_name": "Ablim1", "organism": "Mouse", "refseq_name": "actin-binding LIM protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001096647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096647", "type": "external" } ], "gene_names_uniprotkb": "Ablim1; Ablim; Kiaa0059", "gene_names_refseq": "2210411C18Rik; 2610209L21Rik; 4833406P10Rik; 9330196J19Rik; Ablim1; Limab1; mKIAA0059", "protein_names_uniprotkb": "Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; abLIM-1", "protein_names_refseq": "actin-binding LIM protein 1 isoform 2; actin-binding LIM protein family member 1; actin-binding double zinc finger protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:226251)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11163266;12849746;15345747;16452087;17242355;18034455;18630941;19458039;21183079;21540332;21750661;22517741;22645316;26495903;29187734;29237092;29904924;29921413;32782141;32848054;34428180;34678516;34887587;35822049;37507081;40885482;9245787", "class_list": "", "function": "ABLIM1 is associated with the regulation of preosteoclast motility via the PI3K/Akt/Rac1 pathway during RANKL-mediated osteoclastogenesis., [RefSeq, PubMed]; AbLIM1 regulated the localization of tubulin, migration, and fusion in osteoclasts. Thus, these results indicate that abLIM1 negatively controls osteoclast differentiation by regulating cell migration and fusion mediated via actin formation., [RefSeq, PubMed]; May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q80U86;Q8BIR9;Q8K4G3;Q8K4G4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0060271 cilium assembly;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q8K4G5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V140-1", "uniprot_id": [ { "id": "ACRBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V140", "type": "external" } ], "mass": 61141.0, "length": 540, "protein_name": "Acrosin-binding protein", "gene_name": "Acrbp", "organism": "Mouse", "refseq_name": "acrosin-binding protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_001120812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120812", "type": "external" } ], "gene_names_uniprotkb": "Acrbp", "gene_names_refseq": "Acrbp; OY-TES-1; sp32", "protein_names_uniprotkb": "Acrosin-binding protein; ACRPB-C; Acrosin-binding protein, 32 kDa form, mature form; Acrosin-binding protein, 60 kDa form; Proacrosin-binding protein sp32; Sp32", "protein_names_refseq": "acrosin-binding protein isoform 2 precursor; acrosin-binding protein, 60 kDa form", "tax_id": 10090, "disease": "", "pathway": " (mmu:54137)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22357636;23426433;27303034;29716999;30606959", "class_list": "", "function": "ACRBP-null male mice showed a severely reduced fertility, because of malformation of the acrosome., [RefSeq, PubMed]; Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data suggest that the fertility defect in PCSK4 (proprotein convertase subtilisin/kexin type 4) knockout mice is due, in part, to altered processing/proteolysis of ACRBP as well as structural abnormalities in sperm heads and acrosomes., [RefSeq, PubMed]; Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis (PubMed:27303034). Partially also contributes to the assembly of acrosomal proteins to form an acrosomal granule (PubMed:27303034)., [UniProtKB, PubMed]; Male subfertility of ACRBP-deficient mice may be attributed to incompleteness of the acrosome reaction rather than impairment in sperm migration from the uterus to the oviduct., [RefSeq, PubMed]; Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis (PubMed:27303034). In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis (PubMed:27303034)., [UniProtKB, PubMed]; Setd2 deficiency results in complete loss of H3K36me3 and significantly decreases expression of thousands of genes, including those encoding acrosin-binding protein 1 (Acrbp1) and protamines, required for spermatogenesis., [RefSeq, PubMed]; Two forms of Acrbp mRNA-wild-type Acrbp-W and variant Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in the mouse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62253;Q62254;Q8C621;Q91VQ1", "ec_number_list": [], "go_molecular_function": "GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V140-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41216-1", "uniprot_id": [ { "id": "ACSL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P41216", "type": "external" } ], "mass": 77951.0, "length": 699, "protein_name": "Long-chain-fatty-acid--CoA ligase 1", "gene_name": "Acsl1", "organism": "Mouse", "refseq_name": "long-chain-fatty-acid--CoA ligase 1 isoform 1", "refseq_ac": [ { "id": "NP_001289092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289092", "type": "external" } ], "gene_names_uniprotkb": "Acsl1; Acsl2; Facl2", "gene_names_refseq": "Acas1; Acas; Acsl1; Acs; FACS; Facl2; LACS 1; LACS1", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 1; 6.2.1.15; 6.2.1.24; 6.2.1.3; Arachidonate--CoA ligase; LACS 1; Long-chain acyl-CoA synthetase 1; Phytanate--CoA ligase", "protein_names_refseq": "acetate-CoA ligase; acetyl-CoA synthetase; acetyl-Coenzyme A synthetase 1 (ADP forming); arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 2; long-chain acyl-CoA synthetase 1; long-chain-fatty-acid--CoA ligase 1 isoform 1; long-chain-fatty-acid--CoA ligase 1; phytanate--CoA ligase", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14081); (R-MMU-2046105); (R-MMU-2046106); (R-MMU-75876)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19648649;21183079;21245374;21750661;23426369;23576753;30084848;30779550;31219806;34428180;36064721;36210013;36288343;37453647;37507081;39442449;39927985", "class_list": "", "function": "ACSL1 positively regulates adipogenic differentiation., [RefSeq, PubMed]; Acsl1 is required for heart fatty acid oxidation. Heart-specific Acsl1 deficiency causes cardiac hypertrophy., [RefSeq, PubMed]; Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages, [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe a knock-out model of acyl-CoA synthetase-1 (ACSL1) and its effects in liver and in whole body metabolism., [RefSeq, PubMed]; The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTG6;Q9DBK5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0050197 phytanate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P41216-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K209-1", "uniprot_id": [ { "id": "AGRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K209", "type": "external" } ], "mass": 77255.0, "length": 687, "protein_name": "Adhesion G protein-coupled receptor G1", "gene_name": "Adgrg1", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor G1 isoform c precursor", "refseq_ac": [ { "id": "NP_001185823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185823", "type": "external" } ], "gene_names_uniprotkb": "Adgrg1; Cyt28; Gpr56", "gene_names_refseq": "Adgrg1; Cyt28; Gpr56; TM7LN4; TM7XN1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G1; ADGRG1 C-terminal fragment; ADGRG1 N-terminal fragment; ADGRG1 NT; ADGRG1-CT; G protein-coupled receptor 56; GPR56 7TM; GPR56 C-terminal fragment; GPR56 CT; GPR56 N-terminal fragment; GPR56 NT; GPR56 extracellular subunit; GPR56 seven-transmembrane subunit; GPR56 subunit alpha; GPR56 subunit beta; GPR56(C); GPR56(N); Serpentine receptor cyt28", "protein_names_refseq": "G-protein coupled receptor 56; adhesion G-protein coupled receptor G1 isoform c precursor; secretin receptor; serpentine receptor cyt28", "tax_id": 10090, "disease": "complex cortical dysplasia with other brain malformations 14A (Disease Ontology:DOID:0080922); complex cortical dysplasia with other brain malformations 14B (Disease Ontology:DOID:0080924)", "pathway": " (mmu:14766)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;15044805;17576745;18378689;18509043;19515912;20981830;21750661;21768377;22238662;23478665;24531968;25428506;26740625;27068534;27657451;29809138;30899004;31628191;32452062;33097663;33300544;34428180;39389061", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for phosphatidylserine, which is involved in microglia-mediated synapse pruning during development (PubMed:32452062). Required to maintain appropriate synaptic numbers in several brain regions in a time- and circuit-dependent fashion: phosphatidylserine-binding acts as a 'eat-me' signal for apoptotic cells, leading to microglial engulfment of phosphatidylserine-positive synapses (PubMed:32452062)., [UniProtKB, PubMed]; Adhesion G protein-coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions (PubMed:31628191, PubMed:39389061). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:39389061). ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (PubMed:18378689, PubMed:33097663, PubMed:39389061). Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury (PubMed:39389061). Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2 (By similarity). Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (PubMed:18509043). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway (PubMed:19515912, PubMed:21768377, PubMed:24531968). Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (PubMed:29809138). Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner (PubMed:33097663). Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (By similarity). Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche (PubMed:23478665). Plays an essential role in testis development (PubMed:20981830)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Preferential expression in neuronal progenitor cells of the cerebral cortical ventricular and subventricular zones duing periods of neurogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR17;Q9QZT2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0050840 extracellular matrix binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0097451 glial limiting end-foot", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q8K209-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BL65-1", "uniprot_id": [ { "id": "ABLM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BL65", "type": "external" } ], "mass": 68107.0, "length": 612, "protein_name": "Actin-binding LIM protein 2", "gene_name": "Ablim2", "organism": "Mouse", "refseq_name": "actin-binding LIM protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001171168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171168", "type": "external" } ], "gene_names_uniprotkb": "Ablim2", "gene_names_refseq": "Ablim2; C230091L11", "protein_names_uniprotkb": "Actin-binding LIM protein 2; Actin-binding LIM protein family member 2; abLIM-2", "protein_names_refseq": "abLIM-2; actin-binding LIM protein 2 isoform 2; actin-binding LIM protein family member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231148)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "16005990;16452087;17194709;21183079;21750661;22517741;22645316;30084848;30779550;32848054;34428180;34678516;40021952;40885482", "class_list": "", "function": "ABLIM-2 and -3 associate with STARS and directly bind F-actin, [RefSeq, PubMed]; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The highest expression of both isoforms was observed in rat brain and eye and in mouse embryos. ABLIM2 protein was necessary for the normal functioning of neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B2RUF8;Q6H8P8;Q80WK6;Q8BUT1;Q8BXI7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030016 myofibril;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8BL65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC66-1", "uniprot_id": [ { "id": "ADIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC66", "type": "external" } ], "mass": 70956.0, "length": 615, "protein_name": "Afadin- and alpha-actinin-binding protein", "gene_name": "Ssx2ip", "organism": "Mouse", "refseq_name": "afadin- and alpha-actinin-binding protein isoform b", "refseq_ac": [ { "id": "NP_001240697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240697", "type": "external" } ], "gene_names_uniprotkb": "Ssx2ip", "gene_names_refseq": "Adip; Ssx2ip", "protein_names_uniprotkb": "Afadin- and alpha-actinin-binding protein; ADIP; Afadin DIL domain-interacting protein", "protein_names_refseq": "SSX 2 interacting protein; afadin DIL domain-interacting protein; afadin- and alpha-actinin-binding protein isoform b; afadin- and alpha-actinin-binding protein; synovial sarcoma, X 2 interacting protein; synovial sarcoma, X breakpoint 2 interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:99167)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12446711;21183079;21750661;22027834;24356449;33987909", "class_list": "", "function": "Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (PubMed:12446711). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (PubMed:22027834). Involved in ciliogenesis (By similarity). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Localization at cell-cell adherens junctions, [RefSeq, PubMed]; OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring., [RefSeq, PubMed]; The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone., [RefSeq, PubMed]; The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG59;Q8C7X0;Q8K2F7", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005912 adherens junction;GO:0031252 cell leading edge;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007155 cell adhesion;GO:2000145 regulation of cell motility;GO:0060271 cilium assembly;GO:0007098 centrosome cycle;GO:0035020 regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VC66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59672-1", "uniprot_id": [ { "id": "ANS1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P59672", "type": "external" } ], "mass": 125242.0, "length": 1150, "protein_name": "Ankyrin repeat and SAM domain-containing protein 1A", "gene_name": "Anks1a; Anks1", "organism": "Mouse", "refseq_name": "ankyrin repeat and SAM domain-containing protein 1A isoform 2", "refseq_ac": [ { "id": "NP_001272970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272970", "type": "external" } ], "gene_names_uniprotkb": "Anks1a; Anks1; Anks1; Kiaa0229; Odin", "gene_names_refseq": "Anks1a; Anks1; mKIAA0229", "protein_names_uniprotkb": "Ankyrin repeat and SAM domain-containing protein 1A; Odin", "protein_names_refseq": "Odin; ankyrin repeat and SAM domain-containing protein 1A isoform 2; ankyrin repeat and SAM domain-containing protein 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:224650)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12439753;15345747;15500253;17242355;17875921;20173027;21183079;21750661;38123547", "class_list": "", "function": "ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells. Erratum:[Nat Commun. 2024 Apr 9;15(1):3062. doi: 10.1038/s41467-024-47249-w. PMID: 38594263] Publication Status: Online-Only, [RefSeq, PubMed]; Odin expression in mice is not essential for any major developmental pathway; it could play a significant functional role to negatively regulate growth factor receptor signaling pathways. [Odin], [RefSeq, PubMed]; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQG0", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0043005 neuron projection;GO:0005737 cytoplasm;GO:0042995 cell projection", "go_biological_process": "GO:0016322 neuron remodeling;GO:0048013 ephrin receptor signaling pathway;GO:0006929 substrate-dependent cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P59672-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQK5-1", "uniprot_id": [ { "id": "ACAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQK5", "type": "external" } ], "mass": 87211.0, "length": 770, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "gene_name": "Acap2", "organism": "Mouse", "refseq_name": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "refseq_ac": [ { "id": "NP_084414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084414", "type": "external" } ], "gene_names_uniprotkb": "Acap2; Centb2; Kiaa0041", "gene_names_refseq": "4832442G16; 9530039J15Rik; Acap2; CNT-B2; Centb2; mKIAA0041", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; Centaurin-beta-2; Cnt-b2", "protein_names_refseq": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; centaurin, beta 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:78618)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15592455;17114649;17242355;21183079;21750661;22045739;23572513;25428506;26740625;28135057;28528544;30084848;34203471;34428180", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GTPase-activating protein for the ADP ribosylation factor family., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHL4;Q811F3;Q9CTS8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0001726 ruffle", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0032456 endocytic recycling;GO:0030029 actin filament-based process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6ZQK5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4J6-1", "uniprot_id": [ { "id": "MRTFA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4J6", "type": "external" } ], "mass": 102546.0, "length": 964, "protein_name": "Myocardin-related transcription factor A", "gene_name": "Mrtfa", "organism": "Mouse", "refseq_name": "myocardin-related transcription factor A isoform 1", "refseq_ac": [ { "id": "NP_694629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694629", "type": "external" } ], "gene_names_uniprotkb": "Mrtfa; Bsac; Mal; Mkl1", "gene_names_refseq": "AMKL; Bsac; Mal; Mkl1; Mrtf-A; Mrtfa", "protein_names_uniprotkb": "Myocardin-related transcription factor A; Basic SAP coiled-coil transcription activator; MKL/myocardin-like protein 1; MRTF-A; Megakaryoblastic leukemia 1 protein homolog; Megakaryocytic acute leukemia protein homolog", "protein_names_refseq": "MKL (megakaryoblastic leukemia)/myocardin-like 1; MKL/myocardin-like protein 1; basic SAP and coiled-coil domains; basic SAP coiled-coil transcription activator; megakaryoblastic leukemia (translocation) 1 homolog; megakaryocytic acute leukemia protein homolog; myocardial related transcription factor A; myocardin-related transcription factor A isoform 1", "tax_id": 10090, "disease": "immunodeficiency 66 (Disease Ontology:DOID:0111998); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)", "pathway": " (mmu:223701); (R-MMU-3899300); (R-MMU-5663220)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "12019265;12397177;12732141;14970199;17588931;19008859;19350017;20818336;21673315;21750661;23558171;24732378;25428506;25759381;27304076;30084848;32848054;34428180;35822049;37770456;38713765;39222836;40021952;40885482", "class_list": "", "function": "BSAC is a novel transcriptional activator with antiapoptotic function, [RefSeq, PubMed]; Interacts with serum response factor and stimulates its transcriptional activity, [RefSeq, PubMed]; MKL1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells, [RefSeq, PubMed]; MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage MKL1 contributes to cardiac fibrosis in a mouse model of myocardial infarction., [RefSeq, PubMed]; Rho-actin signaling regulates the subcellular localization of the myocardin-related SRF coactivator MAL, [RefSeq, PubMed]; The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex., [RefSeq, PubMed]; Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q642U1", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0003785 actin monomer binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2000491 positive regulation of hepatic stellate cell activation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8K4J6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1K7-1", "uniprot_id": [ { "id": "APCL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1K7", "type": "external" } ], "mass": 243139.0, "length": 2274, "protein_name": "Adenomatous polyposis coli protein 2", "gene_name": "Apc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Apc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenomatous polyposis coli protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); complex cortical dysplasia with other brain malformations 10 (Disease Ontology:DOID:0061143); familial adenomatous polyposis 1 (Disease Ontology:DOID:0080409); autosomal recessive intellectual developmental disorder 74 (Disease Ontology:DOID:0081218); Sotos syndrome 3 (Disease Ontology:DOID:0112104); intestinal cancer (Disease Ontology:DOID:10155); alcohol use disorder (Disease Ontology:DOID:1574); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:23805)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10021369;15018807;17310996;21183079;21750661;22517741;22645316;25753423;26192747;31219806;32848054;34428180;40021952;40885482", "class_list": "", "function": "Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 8, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008013 beta-catenin binding;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005884 actin filament", "go_biological_process": "GO:0001708 cell fate specification;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9Z1K7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TMQ6-1", "uniprot_id": [ { "id": "ANG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TMQ6", "type": "external" } ], "mass": 16425.0, "length": 144, "protein_name": "Angiogenin-4", "gene_name": "Ang4", "organism": "Mouse", "refseq_name": "angiogenin-4 precursor", "refseq_ac": [ { "id": "NP_808212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808212", "type": "external" } ], "gene_names_uniprotkb": "Ang4", "gene_names_refseq": "Ang4; Raa4; Rnase5d", "protein_names_uniprotkb": "Angiogenin-4; 3.1.27.-", "protein_names_refseq": "angiogenin-4 precursor; angiogenin-4; ribonuclease A a4", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 9 (Disease Ontology:DOID:0060200); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); eosinophilic esophagitis (Disease Ontology:DOID:13922); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cerebral infarction (Disease Ontology:DOID:3526); trophoblastic neoplasm (Disease Ontology:DOID:4085); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:219033)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12548285;15772759;17279775;22970115;24358364;36881568", "class_list": "", "function": "Ang1 and Ang4 differentially affect colitis and carcinogenesis in an AOM-DSS mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro)., [UniProtKB, PubMed, PubMed]; Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge. Publication Status: Online-Only, [RefSeq, PubMed]; Protein structure of angiogenin 4, [RefSeq, PubMed]; The cellular source of mouse Ang4 in the colon following T. muris infection is the goblet cell and expression is under the control of IL-13., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWE7;Q80XS4;Q80Z85", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0001878 response to yeast;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TMQ6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2S7-1", "uniprot_id": [ { "id": "AMGO3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2S7", "type": "external" } ], "mass": 55625.0, "length": 508, "protein_name": "Amphoterin-induced protein 3", "gene_name": "Amigo3", "organism": "Mouse", "refseq_name": "amphoterin-induced protein 3 precursor", "refseq_ac": [ { "id": "NP_796249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249", "type": "external" } ], "gene_names_uniprotkb": "Amigo3; Ali3; Kiaa1851", "gene_names_refseq": "Amigo3; E430002N15Rik; ali3; mKIAA1851", "protein_names_uniprotkb": "Amphoterin-induced protein 3; AMIGO-3; Alivin-3", "protein_names_refseq": "AMIGO-3; alivin 3; amphoterin induced gene and ORF 3; amphoterin-induced protein 3 precursor; amphoterin-induced protein 3", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:320844)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12629050;25428506;27802388;30084848;34428180", "class_list": "", "function": "May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPH1;Q8CEB3", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0010977 negative regulation of neuron projection development;GO:0007420 brain development;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C2S7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NH0-1", "uniprot_id": [ { "id": "ANR17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NH0", "type": "external" } ], "mass": 274213.0, "length": 2603, "protein_name": "Ankyrin repeat domain-containing protein 17", "gene_name": "Ankrd17", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 17 isoform a", "refseq_ac": [ { "id": "NP_112148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112148", "type": "external" } ], "gene_names_uniprotkb": "Ankrd17; Foe; Gtar; Kiaa0697", "gene_names_refseq": "4933425K22Rik; A130069E23Rik; A930008M01; Ankrd17; Foe; Gtar; Mask; mKIAA0697", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 17; Ankyrin repeat domain-containing protein FOE; Gene trap ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain containing protein FOE; ankyrin repeat domain-containing protein 17 isoform a; ankyrin repeat domain-containing protein 17; gene trap ankyrin repeat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:81702)", "pathway_count": 1, "publication_count": 43, "publication_id_list": "10.1101/2023.09.13.557529;11165478;11740861;17242355;18299400;19224205;19619540;20173027;21183079;21750661;21952136;22190705;22517741;22645316;22872234;24129315;25428506;25428507;25605945;27669760;29187734;29237092;30016717;30059200;30084848;30779550;31219806;31599954;32152506;32782141;32848054;33649389;33725478;34203471;34428180;34678516;35820727;35822049;36852467;37828378;40021952;40885482;40997131", "class_list": "", "function": "ANKRD17 expression was predominantly restricted to pachytene spermatocytes and round spermatids. ANKRD17 was diffusely distributed throughout the nucleus of pachytene cells but excluded from the XY body and other heterochromatic regions. Publication Status: Online-Only, [RefSeq, PubMed]; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors RIGI and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (PubMed:19619540)., [UniProtKB, PubMed, UniProtKB]; Data demonstrate the indispensability of Ankrd17 functioning for vascular maturation during early development., [RefSeq, PubMed]; This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 53, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 53, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 53, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 60, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV99;Q5F4T7;Q6PG69;Q6ZQ66;Q8CHT4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0000785 chromatin", "go_biological_process": "GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0001955 blood vessel maturation;GO:0006275 regulation of DNA replication;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 10.6, "record_id": "Q99NH0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54774-1", "uniprot_id": [ { "id": "AP3D1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54774", "type": "external" } ], "mass": 135081.0, "length": 1199, "protein_name": "AP-3 complex subunit delta-1", "gene_name": "Ap3d1", "organism": "Mouse", "refseq_name": "AP-3 complex subunit delta-1 isoform 1", "refseq_ac": [ { "id": "NP_031486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031486", "type": "external" } ], "gene_names_uniprotkb": "Ap3d1; Ap3d", "gene_names_refseq": "Ap3d1; Ap3d; Bolvr; mBLVR1; mh; mocha", "protein_names_uniprotkb": "AP-3 complex subunit delta-1; AP-3 complex subunit delta; Adaptor-related protein complex 3 subunit delta-1; Delta-adaptin; mBLVR1", "protein_names_refseq": "AP-3 complex subunit delta-1 isoform 1; AP-3 complex subunit delta-1; adapter-related protein complex 3 subunit delta-1; adaptor-related protein complex 3 subunit delta-1; adaptor-related protein complex 3, delta subunit; adaptor-related protein complex AP-3, delta subunit; delta-adaptin", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 1 (Disease Ontology:DOID:0060539); Hermansky-Pudlak syndrome 2 (Disease Ontology:DOID:0060540); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:11776)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "16452087;17242355;18630941;19131326;19144319;21183079;21750661;21998198;25428507;26495903;30084848;33300544;33649389;34428180;34874227;35820727;36445457;9420263", "class_list": "", "function": "A homozygous AP3D1 missense variant in patients with sensorineural hearing loss as the leading manifestation., [RefSeq, PubMed]; Long noncoding RNA SNHG8 accelerates acute gouty arthritis development by upregulating AP3D1 in mice., [RefSeq, PubMed]; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). Involved in process of CD8+ T-cell and NK cell degranulation (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:21998198)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0030424 axon;GO:0043195 terminal bouton", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0060155 platelet dense granule organization;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O54774-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESC8-1", "uniprot_id": [ { "id": "AFF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESC8", "type": "external" } ], "mass": 126639.0, "length": 1160, "protein_name": "AF4/FMR2 family member 4", "gene_name": "Aff4", "organism": "Mouse", "refseq_name": "AF4/FMR2 family member 4 isoform 1", "refseq_ac": [ { "id": "NP_291043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291043", "type": "external" } ], "gene_names_uniprotkb": "Aff4; Alf4", "gene_names_refseq": "AF5Q31; Aff4; Alf4; Laf4l; MCEF", "protein_names_uniprotkb": "AF4/FMR2 family member 4", "protein_names_refseq": "AF4/FMR2 family member 4 isoform 1; ALL1 fused gene from 5q31", "tax_id": 10090, "disease": "skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:93736); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10704283;16024815;21183079;21750661;22195968;23273992;23806337;25605945;29187734;31219806;33878354;34428180;36149892;36401176;36852467", "class_list": "", "function": "AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival., [RefSeq, PubMed]; AFF4 regulates cellular adipogenic differentiation via targeting autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of the transcription factor, AFF4, as a new target of miR-203 in CNS., [RefSeq, PubMed]; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RST9;Q8C6K4;Q8C6W3;Q8CCH3", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0001650 fibrillar center;GO:0016604 nuclear body", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0050877 nervous system process;GO:0007286 spermatid development;GO:0006354 DNA-templated transcription elongation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9ESC8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61288-1", "uniprot_id": [ { "id": "ACVL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61288", "type": "external" } ], "mass": 56519.0, "length": 502, "protein_name": "Activin receptor type-1-like", "gene_name": "Acvrl1", "organism": "Mouse", "refseq_name": "activin receptor type-1-like isoform a precursor", "refseq_ac": [ { "id": "NP_001264186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264186", "type": "external" } ], "gene_names_uniprotkb": "Acvrl1; Acvrlk1; Alk-1", "gene_names_refseq": "Acvrl1; Acvrlk1; Alk1", "protein_names_uniprotkb": "Activin receptor type-1-like; 2.7.11.30; ALK-1; Activin receptor-like kinase 1; SKR3; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; TSR-I", "protein_names_refseq": "SKR3; TGF-B superfamily receptor type I; TSR-I; activin receptor type-1-like isoform a precursor; activin receptor type-1-like; activin receptor-like kinase 1; serine/threonine-protein kinase receptor R3", "tax_id": 10090, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); arteriovenous malformation (Disease Ontology:DOID:11294); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:11482); (R-MMU-201451)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;26495903;26740625;28011936;30899004;35984892;38064044;39196046;7488127;7750489", "class_list": "", "function": "ALK1 Deficiency Impairs the Wound-Healing Process and Increases Mortality in Murine Model of Myocardial Infarction., [RefSeq, PubMed]; Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice., [RefSeq, PubMed]; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61289;Q91YR0", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0070724 BMP receptor complex", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61288-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811D2-1", "uniprot_id": [ { "id": "ANR26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811D2", "type": "external" } ], "mass": 180647.0, "length": 1581, "protein_name": "Ankyrin repeat domain-containing protein 26", "gene_name": "Ankrd26", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ankrd26; Kiaa1074", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 26", "protein_names_refseq": "", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:232339); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16364570;17242355;18162531;21750661;21952136;22666460;24633808;34428180;35820727;40021952", "class_list": "", "function": "Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZS2;Q9CS61", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0046621 negative regulation of organ growth;GO:0019216 regulation of lipid metabolic process;GO:0019217 regulation of fatty acid metabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q811D2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60710-1", "uniprot_id": [ { "id": "ACTB_MOUSE", "url": "https://www.uniprot.org/uniprot/P60710", "type": "external" } ], "mass": 41737.0, "length": 375, "protein_name": "Actin, cytoplasmic 1", "gene_name": "Actb", "organism": "Mouse", "refseq_name": "actin, cytoplasmic 1", "refseq_ac": [ { "id": "NP_031419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031419", "type": "external" } ], "gene_names_uniprotkb": "Actb", "gene_names_refseq": "Actb; Actx; E430023M04Rik; beta-actin", "protein_names_uniprotkb": "Actin, cytoplasmic 1; 3.6.4.-; Beta-actin", "protein_names_refseq": "A-X actin-like protein; actin, beta, cytoplasmic; actin, cytoplasmic 1; melanoma X-actin", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:11461); (R-MMU-190873); (R-MMU-196025); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-418990); (R-MMU-437239); (R-MMU-4420097); (R-MMU-445095); (R-MMU-446353); (R-MMU-5626467); (R-MMU-5663213); (R-MMU-5663220); (R-MMU-5674135); (R-MMU-8856828); (R-MMU-9013418); (R-MMU-9764561); (R-MMU-9913351); (R-MMU-9958825)", "pathway_count": 19, "publication_count": 39, "publication_id_list": "10.1101/2023.09.13.557529;11180120;12522145;16139798;18250455;20173027;21128978;213279;21750661;21969592;22645316;23558171;23911929;24806444;25428507;25759381;28315936;28935714;29237092;30016717;30626964;30659401;3084797;31605441;33300544;34428180;34887587;35984892;36210013;36288343;37453647;37507081;3754329;37952086;39627609;39927985;7522249;8746565;9707606", "class_list": "glycogene", "function": "Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB, UniProtKB]; This gene encodes a member of the actin family of proteins. Actins are highly conserved proteins that are among the most abundant proteins in eukaryotic cells and are involved in cell motility, structure, and integrity. Localization, stability, and translation of the transcribed mRNA are regulated through the binding of multiple factors to its 3' UTR sequence. Homozygous knockout mice for this gene exhibit embryonic lethality. Numerous pseudogenes of this gene have been identified in the mouse genome. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 12, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P02570;P70514;P99021;Q11211;Q3TI89;Q3TVP6;Q64316;Q6ZWM3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P60710-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTI7-1", "uniprot_id": [ { "id": "ANR52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTI7", "type": "external" } ], "mass": 115032.0, "length": 1076, "protein_name": "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C", "gene_name": "Ankrd52", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C", "refseq_ac": [ { "id": "NP_766378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766378", "type": "external" } ], "gene_names_uniprotkb": "Ankrd52", "gene_names_refseq": "6430544C07; Ankrd52; G431002C21Rik", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; PP6-ARS-C; Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C", "protein_names_refseq": "PP6-ARS-C; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; serine/threonine-protein phosphatase 6 regulatory subunit ARS-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:237615)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;21952136;22872234;34428180;35820727;36210013", "class_list": "", "function": "Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148Z3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BTI7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97783-1", "uniprot_id": [ { "id": "AF1Q_MOUSE", "url": "https://www.uniprot.org/uniprot/P97783", "type": "external" } ], "mass": 10029.0, "length": 90, "protein_name": "Protein AF1q", "gene_name": "Mllt11", "organism": "Mouse", "refseq_name": "protein AF1q", "refseq_ac": [ { "id": "NP_064298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064298", "type": "external" } ], "gene_names_uniprotkb": "Mllt11; Af1q", "gene_names_refseq": "Af1q; Mllt11; Zfp692", "protein_names_uniprotkb": "Protein AF1q", "protein_names_refseq": "ALL1-fused gene from chromosome 1q; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); protein AF1q; translocated to, 11; zinc finger protein 692", "tax_id": 10090, "disease": "", "pathway": " (mmu:56772)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15530661;21183079;25428506;30084848;35379703;35820727;36131367", "class_list": "", "function": "Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate., [UniProtKB, UniProtKB]; Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development., [RefSeq, PubMed]; Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11., [RefSeq, PubMed]; The mouse Af1q, homologue of human AF1q, was found to be significantly up-regulated during the neuronal production from neural stem cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0097191 extrinsic apoptotic signaling pathway;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97783-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01338-1", "uniprot_id": [ { "id": "ADA2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01338", "type": "external" } ], "mass": 50555.0, "length": 465, "protein_name": "Alpha-2A adrenergic receptor", "gene_name": "Adra2a", "organism": "Mouse", "refseq_name": "alpha-2A adrenergic receptor", "refseq_ac": [ { "id": "NP_031443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031443", "type": "external" } ], "gene_names_uniprotkb": "Adra2a", "gene_names_refseq": "Adra-2a; Adra-2; Adra2a; alpha(2A)AR; alpha2-C10; alpha2A-AR; alpha2A", "protein_names_uniprotkb": "Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR", "protein_names_refseq": "alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha2A-adrenergic receptor; subtype alpha2-C10", "tax_id": 10090, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); substance abuse (Disease Ontology:DOID:302); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11551); (R-MMU-390696); (R-MMU-392023); (R-MMU-400042); (R-MMU-418594); (R-MMU-418597); (R-MMU-5683826)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10647009;1353249;24129315;34428180", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (PubMed:10647009)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3URE6", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0032795 heterotrimeric G-protein binding;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0097305 response to alcohol;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0051044 positive regulation of membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q01338-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTE0-1", "uniprot_id": [ { "id": "ADAM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTE0", "type": "external" } ], "mass": 84534.0, "length": 751, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 5", "gene_name": "Adam5", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001258986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258986", "type": "external" } ], "gene_names_uniprotkb": "Adam5; Tmdc2", "gene_names_refseq": "Adam5; tMDC II; tMDCII", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 5; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; tMDC II", "protein_names_refseq": "a disintegrin and metalloprotease domain (ADAM) 5; disintegrin and metalloproteinase domain-containing protein 5 isoform 2 precursor; disintegrin and metalloproteinase domain-containing protein 5; transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II", "tax_id": 10090, "disease": "", "pathway": " (mmu:11499)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;20945367;21750661;23969891;25428506;34428180;36210013;7750654", "class_list": "", "function": "This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]., [RefSeq]; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTE2;Q52KQ5;Q60623;Q60816;Q8CDV5;Q9D4F0", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3TTE0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHD9-1", "uniprot_id": [ { "id": "AGAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHD9", "type": "external" } ], "mass": 124511.0, "length": 1186, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "gene_name": "Agap2", "organism": "Mouse", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001028435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028435", "type": "external" } ], "gene_names_uniprotkb": "Agap2; Centg1; Kiaa0167", "gene_names_refseq": "AGAP-2; Agap2; Centg1; PIKE; cnt-g1; mKIAA0167", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; AGAP-2; Centaurin-gamma-1; Cnt-g1; PIKE; Phosphatidylinositol 3-kinase enhancer", "protein_names_refseq": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; phosphatidylinositol 3-kinase enhancer", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:216439)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18469807;20068140;21183079;21750661;22517741;24449917;28096359;28404596;32848054;33300544;34428180;40885482", "class_list": "", "function": "Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses., [RefSeq, PubMed]; Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice. DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn-KO mice than in wild-type mice exposed to alpha synuclein and MPTP., [RefSeq, PubMed]; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development., [RefSeq, PubMed]; PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation., [RefSeq, PubMed]; PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system, [RefSeq, PubMed]; The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in multiple defects, including neural deficiencies, while increased expression of this gene has been observed in some tumors. Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU45", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:2000010 positive regulation of protein localization to cell surface;GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3UHD9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMR0-1", "uniprot_id": [ { "id": "ANR27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMR0", "type": "external" } ], "mass": 116809.0, "length": 1048, "protein_name": "Ankyrin repeat domain-containing protein 27", "gene_name": "Ankrd27", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 27 isoform 1", "refseq_ac": [ { "id": "NP_663608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663608", "type": "external" } ], "gene_names_uniprotkb": "Ankrd27; Varp", "gene_names_refseq": "Ankrd27; D330003H11Rik; Varp", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 27; VPS9 domain-containing protein; VPS9-ankyrin-repeat protein", "protein_names_refseq": "VPS9 domain-containing protein; VPS9-ankyrin repeat-containing protein; VPS9-ankyrin-repeat protein; ankyrin repeat domain 27 (VPS9 domain); ankyrin repeat domain-containing protein 27 isoform 1; ankyrin repeat domain-containing protein 27; mFLJ00040 protein", "tax_id": 10090, "disease": "eosinophilic esophagitis (Disease Ontology:DOID:13922)", "pathway": " (mmu:245886); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16525121;17242355;19403694;19745841;21183079;21187289;21750661;22171327;26620560;27066885;34428180", "class_list": "", "function": "May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (By similarity). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (PubMed:19403694, PubMed:21187289). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (PubMed:19745841, PubMed:22171327). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (By similarity). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (By similarity). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes, [RefSeq, PubMed]; Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes., [RefSeq, PubMed]; Varp is a potential Rab21 guanine nucleotide exchange factor and might regulate endosome dynamics in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAU0;Q6P1F9;Q7TNY8;Q8BUD2;Q91W65", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0015031 protein transport;GO:0048812 neuron projection morphogenesis;GO:0045022 early endosome to late endosome transport;GO:0035646 endosome to melanosome transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UMR0-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3Z3-1", "uniprot_id": [ { "id": "AGRG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3Z3", "type": "external" } ], "mass": 58675.0, "length": 524, "protein_name": "Adhesion G protein-coupled receptor G5", "gene_name": "Adgrg5", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor G5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001028640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028640", "type": "external" } ], "gene_names_uniprotkb": "Adgrg5; Gm1109; Gpr114; Pgr27", "gene_names_refseq": "Adgrg5; Gm1109; Gpr114; PGR27", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G5; G protein-coupled receptor 114; G protein-coupled receptor PGR27", "protein_names_refseq": "G protein coupled receptor Gpr114; G protein-coupled receptor 114; G-protein coupled receptor PGR27; adhesion G-protein coupled receptor G5 isoform 2 precursor; probable G-protein coupled receptor 114", "tax_id": 10090, "disease": "", "pathway": " (mmu:382045)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22575658;25428506;25713288;26499266;30084848;34428180;35820727", "class_list": "", "function": "Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking)., [UniProtKB, PubMed]; Orphan adhesion G protein-coupled receptor (aGPCR) (PubMed:22575658). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22575658). ADGRG5 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22575658)., [UniProtKB, PubMed]; This study used cell culture-based assays to investigate 2 natural splice variants within the Stachel sequence of the orphan Gs coupling aGPCR GPR114/ADGRG5., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A6H6A1;G5E8G8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3V3Z3-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60718-1", "uniprot_id": [ { "id": "ADAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60718", "type": "external" } ], "mass": 82375.0, "length": 735, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 2", "gene_name": "Adam2", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 2 preproprotein", "refseq_ac": [ { "id": "NP_033748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033748", "type": "external" } ], "gene_names_uniprotkb": "Adam2; Ftnb", "gene_names_refseq": "Adam2; Ftnb; Ph30-beta", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Fertilin subunit beta; PH-30; PH30-beta; PH30", "protein_names_refseq": "a disintegrin and metalloprotease domain 2 (fertilin beta); disintegrin and metalloproteinase domain-containing protein 2 preproprotein; disintegrin and metalloproteinase domain-containing protein 2; fertilin subunit beta", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:11495); (R-MMU-2534343)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20945367;21183079;37258521;7593287;7750654", "class_list": "", "function": "In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer. Erratum:[Nat Commun. 2023 Sep 5;14(1):5404. doi: 10.1038/s41467-023-41255-0. PMID: 37670013] Publication Status: Online-Only, [RefSeq, PubMed]; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity)., [UniProtKB]; This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is predominantly expressed in the epididymis, where the encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Male mice lacking the encoded protein are infertile and exhibit multiple defects in reproduction. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q60814;Q9D4G3;Q9QWJ0", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008542 visual learning;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60718-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VW7-1", "uniprot_id": [ { "id": "AKNA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VW7", "type": "external" } ], "mass": 153123.0, "length": 1404, "protein_name": "Microtubule organization protein AKNA", "gene_name": "Akna", "organism": "Mouse", "refseq_name": "microtubule organization protein AKNA isoform 1", "refseq_ac": [ { "id": "NP_001038979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038979", "type": "external" } ], "gene_names_uniprotkb": "Akna; Kiaa1968", "gene_names_refseq": "Akna", "protein_names_uniprotkb": "Microtubule organization protein AKNA; AT-hook-containing transcription factor", "protein_names_refseq": "AT-hook-containing transcription factor; microtubule organization protein AKNA isoform 1; microtubule organization protein AKNA", "tax_id": 10090, "disease": "", "pathway": " (mmu:100182)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21606955;30787442;31219806;34428180;40885482", "class_list": "", "function": "Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (PubMed:30787442). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (PubMed:30787442). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (PubMed:30787442). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (PubMed:30787442). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (By similarity). Binds to A/T-rich promoters (By similarity). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable)., [UniProtKB, UniProtKB, PubMed]; Targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC64;Q3TDM3;Q3U3N4;Q6ZPF9;Q8CFV0;Q8R114", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050727 regulation of inflammatory response;GO:0001837 epithelial to mesenchymal transition;GO:0021849 neuroblast division in subventricular zone", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80VW7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZF8-1", "uniprot_id": [ { "id": "AGRB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZF8", "type": "external" } ], "mass": 171314.0, "length": 1522, "protein_name": "Adhesion G protein-coupled receptor B3", "gene_name": "Adgrb3", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor B3 precursor", "refseq_ac": [ { "id": "NP_783573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783573", "type": "external" } ], "gene_names_uniprotkb": "Adgrb3; Bai3", "gene_names_refseq": "A830096D10Rik; Adgrb3; Bai3", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor B3; Brain-specific angiogenesis inhibitor 3", "protein_names_refseq": "G protein-coupled receptor BAI3; adhesion G protein-coupled receptor B3 precursor; brain-specific angiogenesis inhibitor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:210933)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15225653;16452087;21183079;22645316;23628982;27802388;30899004;32848054;37337931;38069416", "class_list": "", "function": "Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression., [RefSeq, PubMed]; Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (PubMed:23628982). Promotes myoblast fusion through ELMO/DOCK1 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "G3XA05", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0043083 synaptic cleft;GO:0098839 postsynaptic density membrane;GO:0150053 cerebellar climbing fiber to Purkinje cell synapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0016322 neuron remodeling;GO:0048814 regulation of dendrite morphogenesis;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q80ZF8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLD6-1", "uniprot_id": [ { "id": "ANR55_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLD6", "type": "external" } ], "mass": 68524.0, "length": 626, "protein_name": "Ankyrin repeat domain-containing protein 55", "gene_name": "Ankrd55", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 55 isoform 2", "refseq_ac": [ { "id": "NP_001161875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161875", "type": "external" } ], "gene_names_uniprotkb": "Ankrd55", "gene_names_refseq": "Ankrd55; C030011J08Rik", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 55", "protein_names_refseq": "ankyrin repeat domain-containing protein 55 isoform 2; ankyrin repeat domain-containing protein 55", "tax_id": 10090, "disease": "", "pathway": " (mmu:77318)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9876, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPX4;Q3UUM0;Q9CTM6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BLD6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1V6-3", "uniprot_id": [ { "id": "ADA22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1V6", "type": "external" } ], "mass": 99715.0, "length": 904, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 22", "gene_name": "Adam22", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor", "refseq_ac": [ { "id": "NP_001007221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007221", "type": "external" } ], "gene_names_uniprotkb": "Adam22", "gene_names_refseq": "2900022I03Rik; Adam22; MDC2", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 22; ADAM 22", "protein_names_refseq": "a disintegrin and metalloprotease domain (ADAM) 22; disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor; disintegrin and metalloproteinase domain-containing protein 22", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 61 (Disease Ontology:DOID:0080434)", "pathway": " (mmu:11496); (R-MMU-5682910)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10433968;15876356;16990550;18974846;20089912;21183079;26269648;30899004;33300544;33397806;37555799;40885482", "class_list": "", "function": "A disintegrin and metalloproteinase 22 activates integrin beta1 through its disintegrin domain to promote the progression of pituitary adenoma., [RefSeq, PubMed]; ADAM22 is closely involved in the correct functioning of the nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention., [RefSeq, PubMed]; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1., [UniProtKB, PubMed, UniProtKB]; This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 19, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5TLI8;Q5TLI9;Q5TLJ0;Q5TLJ1;Q5TLJ2;Q5TLJ3;Q5TLJ4;Q5TLJ5;Q5TLJ6;Q5TLJ7;Q5TLJ8;Q5TLJ9;Q5TLK0;Q5TLK1;Q5TLK2;Q5TLK3;Q5TLK4;Q5TLK5;Q5TLK6;Q5TLK7;Q5TLK8;Q8BSF2;Q9R1V5", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043194 axon initial segment", "go_biological_process": "GO:0006508 proteolysis;GO:0008344 adult locomotory behavior;GO:0022011 myelination in peripheral nervous system;GO:0014037 Schwann cell differentiation;GO:0042063 gliogenesis", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q9R1V6-3", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61337-1", "uniprot_id": [ { "id": "BAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61337", "type": "external" } ], "mass": 22080.0, "length": 204, "protein_name": "Bcl2-associated agonist of cell death", "gene_name": "Bad", "organism": "Mouse", "refseq_name": "bcl2-associated agonist of cell death isoform 1", "refseq_ac": [ { "id": "NP_031548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031548", "type": "external" } ], "gene_names_uniprotkb": "Bad; Bbc6", "gene_names_refseq": "Bad; Bbc2", "protein_names_uniprotkb": "Bcl2-associated agonist of cell death; BAD; Bcl-2-binding component 6; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death", "protein_names_refseq": "bcl-2-binding component 6; bcl-xL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; bcl2-associated agonist of cell death isoform 1", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); prostatic hypertrophy (Disease Ontology:DOID:11132); endometrial cancer (Disease Ontology:DOID:1380); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12015); (R-MMU-111447); (R-MMU-111453); (R-MMU-193648)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10611223;10679322;10880354;10949026;11278362;11342610;11493700;11717309;12049737;12954615;14967141;15849194;16509771;17242355;21183079;21546903;21750661;7834748;8929531;9346240;9381178", "class_list": "", "function": "Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019901 protein kinase binding;GO:0008289 lipid binding;GO:0071889 14-3-3 protein binding;GO:0030346 protein phosphatase 2B binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0008283 cell population proliferation;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61337-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02248-1", "uniprot_id": [ { "id": "CTNB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02248", "type": "external" } ], "mass": 85471.0, "length": 781, "protein_name": "Catenin beta-1", "gene_name": "Ctnnb1", "organism": "Mouse", "refseq_name": "catenin beta-1 isoform 1", "refseq_ac": [ { "id": "NP_001159374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159374", "type": "external" } ], "gene_names_uniprotkb": "Ctnnb1; Catnb", "gene_names_refseq": "Bfc; Catnb; Ctnnb1; Mesc", "protein_names_uniprotkb": "Catenin beta-1; Beta-catenin", "protein_names_refseq": "beta-catenin; catenin (cadherin associated protein), beta 1; catenin beta-1 isoform 1", "tax_id": 10090, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 19 (Disease Ontology:DOID:0070049); exudative vitreoretinopathy 7 (Disease Ontology:DOID:0080264); traumatic brain injury (Disease Ontology:DOID:0081292); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); granulosa cell tumor (Disease Ontology:DOID:2999); carcinoma (Disease Ontology:DOID:305); teratoma (Disease Ontology:DOID:3307); invasive lobular carcinoma (Disease Ontology:DOID:3457); lung carcinoma (Disease Ontology:DOID:3905); lung squamous cell carcinoma (Disease Ontology:DOID:3907); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); fibrolamellar carcinoma (Disease Ontology:DOID:5015); pilomatrixoma (Disease Ontology:DOID:5374); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); neuropathy (Disease Ontology:DOID:870); in situ carcinoma (Disease Ontology:DOID:8719); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:12387); (R-MMU-195253); (R-MMU-196299); (R-MMU-201681); (R-MMU-201722); (R-MMU-3134973); (R-MMU-351906); (R-MMU-3769402); (R-MMU-4086398); (R-MMU-418990); (R-MMU-4641262); (R-MMU-5218920); (R-MMU-525793); (R-MMU-5626467); (R-MMU-8951430); (R-MMU-9762292); (R-MMU-9764561); (R-MMU-9766229); (R-MMU-9768727); (R-MMU-9825892); (R-MMU-9943962); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 23, "publication_count": 158, "publication_id_list": "10.1101/2023.09.13.557529;10581160;10679188;10704462;10772923;10882138;11348595;11590244;11707392;11959983;12408825;12432063;12494996;12640114;12874278;14687547;15063782;1509266;15132997;16325582;17009320;17052462;17053159;17208333;17237784;17242355;17289029;17344318;17925400;18093941;18423204;19104148;19107203;19118113;19224205;19404440;19458197;19816403;19892989;20086044;20133717;20173027;20307497;20361929;20413591;20705246;21183079;21307168;21325504;21623382;21750661;21858154;21952136;21970630;22422579;22510880;22645316;22981369;22992673;23071615;23138569;23308088;23444350;23474484;23691015;23744610;23772418;23935526;24122933;24278135;24911876;25232112;25428506;25428507;25443287;25517963;25520007;25560280;25605945;25670795;25799508;25924235;25970250;25979161;26495903;26739494;26884171;27015268;27292568;27375112;27384483;27507058;27550469;27572314;27595133;28011936;28114280;28254818;28583374;28667836;28848542;29140564;29148101;29161772;29391154;29422917;29449540;29463067;29497040;29530069;29555825;29872041;29872733;30013660;30084848;30389919;30413815;30419856;30568578;30613263;30792401;31219806;31330317;31410155;31413570;31714894;31864412;31900217;31974426;32231574;32308412;32533114;32575075;32681081;32764573;32848054;32929341;32934692;33011305;33188033;33288902;33300544;33443517;33815677;33898435;34346496;34428180;34678516;34887587;35820727;37507081;37828378;39642888;40021952;40885482;7982500;9298899;9783587", "class_list": "", "function": "Key downstream component of the canonical Wnt signaling pathway (PubMed:15132997). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Also acts as a coactivator for other transcription factors, such as NR5A2 (By similarity). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (PubMed:16325582, PubMed:18093941). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (PubMed:21325504). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (PubMed:15132997). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (PubMed:29148101). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (PubMed:29148101)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 39, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q922W1;Q9D335", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0090279 regulation of calcium ion import;GO:0030316 osteoclast differentiation;GO:0030997 regulation of centriole-centriole cohesion;GO:1904888 cranial skeletal system development", "synthesized_glycan_count": 0, "hit_score": 16.9, "record_id": "Q02248-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55041-1", "uniprot_id": [ { "id": "GEM_MOUSE", "url": "https://www.uniprot.org/uniprot/P55041", "type": "external" } ], "mass": 33725.0, "length": 295, "protein_name": "GTP-binding protein GEM", "gene_name": "Gem", "organism": "Mouse", "refseq_name": "GTP-binding protein GEM", "refseq_ac": [ { "id": "NP_034406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034406", "type": "external" } ], "gene_names_uniprotkb": "Gem; Kir", "gene_names_refseq": "Gem", "protein_names_uniprotkb": "GTP-binding protein GEM; GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR", "protein_names_refseq": "GTP binding protein (gene overexpressed in skeletal muscle); GTP-binding mitogen-induced T-cell protein; GTP-binding protein GEM; RAS-like protein KIR", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:14579)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "34085299;34349016;34428180;7809057;7912851;8810259", "class_list": "", "function": "Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity., [UniProtKB]; Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke., [RefSeq, PubMed]; The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZS1", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0051233 spindle midzone;GO:0009898 cytoplasmic side of plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0000278 mitotic cell cycle;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P55041-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09022-1", "uniprot_id": [ { "id": "HXA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P09022", "type": "external" } ], "mass": 36037.0, "length": 331, "protein_name": "Homeobox protein Hox-A1", "gene_name": "Hoxa1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxa1; Era-1; Hox-1.6; Hoxa-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-A1; Early retinoic acid 1; Homeobox protein Hox-1.6; Homeoboxless protein ERA-1-399; Homeotic protein ERA-1-993", "protein_names_refseq": "", "tax_id": 10090, "disease": "Athabaskan brainstem dysgenesis syndrome (Disease Ontology:DOID:0050682); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:15394)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;2569969;2891503;2906112;29465778", "class_list": "", "function": "Sequence-specific transcription factor (PubMed:29465778). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (By similarity). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (PubMed:29465778)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The homeobox domain presumably directs sequence-specific DNA binding. The N-terminal portion of ERA-1-993 may be involved in interactions with one or more other regulatory proteins. Such an interaction could regulate either the DNA-binding activity or the transcriptional regulatory activity of ERA-1-993., [UniProtKB]; The homeoboxless ERA-1-399 protein could act as a competitive inhibitor of the ERA-1-993 protein by competing for interaction with regulatory protein(s) while being unable to bind to DNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P15463", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021569 rhombomere 3 development;GO:0021570 rhombomere 4 development;GO:0021571 rhombomere 5 development;GO:0021754 facial nucleus development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09022-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33175-1", "uniprot_id": [ { "id": "KIF5A_MOUSE", "url": "https://www.uniprot.org/uniprot/P33175", "type": "external" } ], "mass": 117019.0, "length": 1027, "protein_name": "Kinesin heavy chain isoform 5A", "gene_name": "Kif5a", "organism": "Mouse", "refseq_name": "kinesin heavy chain isoform 5A", "refseq_ac": [ { "id": "NP_001034089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034089", "type": "external" } ], "gene_names_uniprotkb": "Kif5a; Kiaa4086; Kif5; Nkhc1", "gene_names_refseq": "D10Bwg0738e; Khc; Kif5a; Kif5; Kns; mKIAA4086", "protein_names_uniprotkb": "Kinesin heavy chain isoform 5A; 5.6.1.3; Kinesin heavy chain neuron-specific 1; NKHC; Neuronal kinesin heavy chain", "protein_names_refseq": "NKHC; kinesin heavy chain isoform 5A; kinesin heavy chain neuron-specific 1; neuronal kinesin heavy chain", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 25 (Disease Ontology:DOID:0081379); hereditary spastic paraplegia 10 (Disease Ontology:DOID:0110763); prostate cancer (Disease Ontology:DOID:10283); spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); multiple sclerosis (Disease Ontology:DOID:2377); hereditary spastic paraplegia (Disease Ontology:DOID:2476); rheumatoid arthritis (Disease Ontology:DOID:7148); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (mmu:16572); (R-MMU-2132295); (R-MMU-5625970); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11986669;12682084;1447303;14600269;18539120;21183079;21750661;21976701;24251978;35430760;35820727;37164288;37258573;39333504;9782088", "class_list": "", "function": "Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model., [RefSeq, PubMed]; Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders. Publication Status: Online-Only, [RefSeq, PubMed]; An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity., [RefSeq, PubMed]; Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant., [RefSeq, PubMed]; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (PubMed:12682084). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (PubMed:21976701). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTP1;Q6PDY7;Q9Z2F9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite;GO:0035253 ciliary rootlet", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0016192 vesicle-mediated transport;GO:0007411 axon guidance;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P33175-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR95-1", "uniprot_id": [ { "id": "NECP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR95", "type": "external" } ], "mass": 29639.0, "length": 275, "protein_name": "Adaptin ear-binding coat-associated protein 1", "gene_name": "Necap1", "organism": "Mouse", "refseq_name": "adaptin ear-binding coat-associated protein 1", "refseq_ac": [ { "id": "NP_080543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080543", "type": "external" } ], "gene_names_uniprotkb": "Necap1", "gene_names_refseq": "1200016B17Rik; Necap1", "protein_names_uniprotkb": "Adaptin ear-binding coat-associated protein 1; NECAP endocytosis-associated protein 1; NECAP-1", "protein_names_refseq": "NECAP endocytosis-associated protein 1; adaptin ear-binding coat-associated protein 1; brain enriched NECAP2 similar protein; clathrin-coated vesicle coat protein; snoRNA MBI-129", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 21 (Disease Ontology:DOID:0080443)", "pathway": " (mmu:67602); (R-MMU-432722); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14555962;14665628;15359277;22517741;22645316;24399846;35822049;40885482;40997131", "class_list": "", "function": "Involved in endocytosis., [UniProtKB, PubMed]; NECAP1 mutation links trafficking pathway in early infantile epileptic encephalopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH13;Q78JW3;Q8C4P1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0098793 presynapse", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0140238 presynaptic endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9CR95-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26450-1", "uniprot_id": [ { "id": "P85A_MOUSE", "url": "https://www.uniprot.org/uniprot/P26450", "type": "external" } ], "mass": 83517.0, "length": 724, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "Pik3r1", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2", "refseq_ac": [ { "id": "NP_001070963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070963", "type": "external" } ], "gene_names_uniprotkb": "Pik3r1", "gene_names_refseq": "PI3K; Pik3r1; p50alpha; p55alpha; p85alpha", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-alpha", "protein_names_refseq": "PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)", "tax_id": 10090, "disease": "agammaglobulinemia 7 (Disease Ontology:DOID:0081139); SHORT syndrome (Disease Ontology:DOID:0111454); immunodeficiency 36 (Disease Ontology:DOID:0111949); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); endometrial cancer (Disease Ontology:DOID:1380); X-linked agammaglobulinemia (Disease Ontology:DOID:14179); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); astroblastoma (Disease Ontology:DOID:7305); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18708); (R-MMU-109704); (R-MMU-112399); (R-MMU-114604); (R-MMU-1250342); (R-MMU-1257604); (R-MMU-1266695); (R-MMU-1433557); (R-MMU-1660499); (R-MMU-180292); (R-MMU-186763); (R-MMU-1963642); (R-MMU-198203); (R-MMU-201556); (R-MMU-202424); (R-MMU-2029485); (R-MMU-210993); (R-MMU-2424491); (R-MMU-2730905); (R-MMU-389357); (R-MMU-416476); (R-MMU-430116); (R-MMU-4420097); (R-MMU-512988); (R-MMU-5654689); (R-MMU-5654695); (R-MMU-5654710); (R-MMU-5654720); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8851907); (R-MMU-8853659); (R-MMU-8980692); (R-MMU-9009391); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424); (R-MMU-9027276); (R-MMU-9035034); (R-MMU-912526); (R-MMU-912631); (R-MMU-9607240); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273); (R-MMU-983695); (R-MMU-9842663); (R-MMU-9927354)", "pathway_count": 55, "publication_count": 32, "publication_id_list": "10353604;10521483;10528161;10646608;11006284;11113178;11294897;11526404;11711534;12052866;14610044;15592455;16249387;1646396;17016431;17947660;18034455;1849460;19915142;20348926;21183079;21750661;25328665;27708159;29237092;34428180;38141889;38353615;38411015;8128248;8943348;9312046", "class_list": "", "function": "Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues (PubMed:27708159). Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926)., [UniProtKB, PubMed, PubMed]; Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention., [RefSeq, PubMed]; Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help., [RefSeq, PubMed]; SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3B3", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0005161 platelet-derived growth factor receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P26450-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61588-1", "uniprot_id": [ { "id": "RND3_MOUSE", "url": "https://www.uniprot.org/uniprot/P61588", "type": "external" } ], "mass": 27368.0, "length": 244, "protein_name": "Rho-related GTP-binding protein RhoE", "gene_name": "Rnd3", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoE", "refseq_ac": [ { "id": "NP_083086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083086", "type": "external" } ], "gene_names_uniprotkb": "Rnd3; Arhe; Rhoe", "gene_names_refseq": "2610017M01Rik; Arhe; Rhoe; Rnd3", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoE; 3.6.5.2; Rho family GTPase 3; Rnd3", "protein_names_refseq": "ras homolog gene family, member E; rho-related GTP-binding protein RhoE", "tax_id": 10090, "disease": "ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:74194); (R-MMU-9696264)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12009891;12773565;15340047;21750661;35820727;37743632;38482696;38744409", "class_list": "", "function": "Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins., [UniProtKB]; Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3., [RefSeq, PubMed]; RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson's disease by suppressing NLRP3 inflammasome activation., [RefSeq, PubMed]; RhoE induces stress fiber disassembly by directly binding ROCK I and inhibiting it from phosphorylating downstream targets, [RefSeq, PubMed]; RhoE inhibits cell cycle progression upstream of the pRb checkpoint., [RefSeq, PubMed]; Rnd3 suppresses endothelial cell pyroptosis in atherosclerosis through regulation of ubiquitination of TRAF6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52199;Q6ZWS2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P61588-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60605-1", "uniprot_id": [ { "id": "UB2G2_MOUSE", "url": "https://www.uniprot.org/uniprot/P60605", "type": "external" } ], "mass": 18566.0, "length": 165, "protein_name": "Ubiquitin-conjugating enzyme E2 G2", "gene_name": "Ube2g2", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 G2", "refseq_ac": [ { "id": "NP_062777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062777", "type": "external" } ], "gene_names_uniprotkb": "Ube2g2; Ubc7", "gene_names_refseq": "1110003O05Rik; D10Xrf369; UBC7; Ubc7p; Ube2g2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 G2; 2.3.2.23; E2 ubiquitin-conjugating enzyme G2; Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme G2; ubiquitin carrier protein G2; ubiquitin-conjugating enzyme 7 homolog; ubiquitin-conjugating enzyme E2 G2; ubiquitin-protein ligase G2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22213); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11278356;21750661", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P56554", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60605-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0Y6-1", "uniprot_id": [ { "id": "AL1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0Y6", "type": "external" } ], "mass": 98709.0, "length": 902, "protein_name": "Cytosolic 10-formyltetrahydrofolate dehydrogenase", "gene_name": "Aldh1l1", "organism": "Mouse", "refseq_name": "cytosolic 10-formyltetrahydrofolate dehydrogenase", "refseq_ac": [ { "id": "NP_081682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081682", "type": "external" } ], "gene_names_uniprotkb": "Aldh1l1; Fthfd", "gene_names_refseq": "1810048F20Rik; Aldh1l1; FDH; Fthfd; Neut2", "protein_names_uniprotkb": "Cytosolic 10-formyltetrahydrofolate dehydrogenase; 1.5.1.6; 10-FTHFDH; Aldehyde dehydrogenase family 1 member L1; FDH", "protein_names_refseq": "10-FTHFDH; 10-formyltetrahydrofolate dehydrogenase; aldehyde dehydrogenase family 1 member L1; cytosolic 10-formyltetrahydrofolate dehydrogenase", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (mmu:107747); (R-MMU-196757)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17111379;17242355;21750661;23806337;31624291;34418053;34428180;37453647", "class_list": "", "function": "Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:31624291). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity)., [UniProtKB, UniProtKB, PubMed]; These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0016155 formyltetrahydrofolate dehydrogenase activity;GO:0033721 aldehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009258 10-formyltetrahydrofolate catabolic process;GO:0046655 folic acid metabolic process;GO:0006740 NADPH regeneration;GO:0035999 tetrahydrofolate interconversion;GO:0006730 one-carbon metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R0Y6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61072-1", "uniprot_id": [ { "id": "ADAM9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61072", "type": "external" } ], "mass": 92079.0, "length": 845, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 9", "gene_name": "Adam9", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 9 isoform 2 precursor", "refseq_ac": [ { "id": "NP_031430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031430", "type": "external" } ], "gene_names_uniprotkb": "Adam9; Kiaa0021; Mdc9; Mltng", "gene_names_refseq": "Adam9; MDC9; Mltng; mKIAA0021", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 9; 3.4.24.-; ADAM 9; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase", "protein_names_refseq": "a disintegrin and metallopeptidase domain 9 (meltrin gamma); a disintegrin and metalloproteinase domain 9 (meltrin gamma); disintegrin and metalloproteinase domain-containing protein 9 isoform 2 precursor; disintegrin and metalloproteinase domain-containing protein 9; metalloprotease/disintegrin/cysteine-rich protein 9; myeloma cell metalloproteinase", "tax_id": 10090, "disease": "cone-rod dystrophy 9 (Disease Ontology:DOID:0111020); Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:11502)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10531379;10825303;11839819;16075062;19273593;19409519;21750661;25605945;25795784;26495903;28011936;30899004;31219806;31599954;32535037;32612155;32906814;33911034;34428180;37828378;38755212;7566181;8146185;8647900;9920899", "class_list": "", "function": "ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-beta1., [RefSeq, PubMed]; ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N(6)-Methyladenosine Dataset. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5 (PubMed:19273593, PubMed:9920899). May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins (PubMed:10825303)., [UniProtKB, PubMed, PubMed, PubMed]; MiR-30e-5p is sponged by Kcnq1ot1 and represses Angiotensin II-induced hypertrophic phenotypes in cardiomyocytes by targeting ADAM9., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 7, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QPP2;Q60618;Q61853;Q80U94", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005178 integrin binding;GO:0008237 metallopeptidase activity;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0016485 protein processing;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q61072-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7B6-1", "uniprot_id": [ { "id": "ACAD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7B6", "type": "external" } ], "mass": 45020.0, "length": 413, "protein_name": "Isobutyryl-CoA dehydrogenase, mitochondrial", "gene_name": "Acad8", "organism": "Mouse", "refseq_name": "isobutyryl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080138", "type": "external" } ], "gene_names_uniprotkb": "Acad8", "gene_names_refseq": "2310016C19Rik; Acad8", "protein_names_uniprotkb": "Isobutyryl-CoA dehydrogenase, mitochondrial; 1.3.8.5; ACAD-8; Acyl-CoA dehydrogenase family member 8", "protein_names_refseq": "ACAD-8; acyl-CoA dehydrogenase family member 8; isobutyryl-CoA dehydrogenase, mitochondrial precursor; isobutyryl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:66948); (R-MMU-70895); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21659959;21750661;23576753;23806337;34428180;36210013;37453647", "class_list": "", "function": "Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; N-ethyl-N-nitrosourea-mediated mutagenesis caused alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK36;Q8BKQ8;Q8CFY9;Q9D2L8", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0003853 short-chain 2-methyl fatty acyl-CoA dehydrogenase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006574 L-valine catabolic process;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D7B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZV8-1", "uniprot_id": [ { "id": "AGRA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZV8", "type": "external" } ], "mass": 143170.0, "length": 1336, "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "Adgra2", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor A2 precursor", "refseq_ac": [ { "id": "NP_473385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385", "type": "external" } ], "gene_names_uniprotkb": "Adgra2; Gpr124; Tem5", "gene_names_refseq": "8430414O08Rik; 9530074E10Rik; Adgra2; Gpr124; Tem5; mKIAA1531", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor A2; G protein-coupled receptor 124; Tumor endothelial marker 5", "protein_names_refseq": "G protein coupled receptor Gpr124; G-protein coupled receptor 124; adhesion G protein-coupled receptor A2 precursor; tumor endothelial marker 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:78560)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11559528;18848646;21071672;21282641;21421844;21750661;25373781;25428506;25558062;26495903;28288111;28803732;30084848;31219806;34428180;35552394;35649360;36210013;38042462", "class_list": "", "function": "An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates., [RefSeq, PubMed]; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:25373781, PubMed:25558062, PubMed:28803732). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781, PubMed:28288111). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2-tethering function does not rely on its G protein-coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury., [RefSeq, PubMed]; The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "B2RRK0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030175 filopodium;GO:1990909 Wnt signalosome;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0010595 positive regulation of endothelial cell migration;GO:0007417 central nervous system development;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q91ZV8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTU0-1", "uniprot_id": [ { "id": "AF1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTU0", "type": "external" } ], "mass": 92175.0, "length": 825, "protein_name": "Actin filament-associated protein 1-like 2", "gene_name": "Afap1l2", "organism": "Mouse", "refseq_name": "actin filament-associated protein 1-like 2 isoform 1", "refseq_ac": [ { "id": "NP_001171267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171267", "type": "external" } ], "gene_names_uniprotkb": "Afap1l2; Kiaa1914", "gene_names_refseq": "Afap1l2; mKIAA1914", "protein_names_uniprotkb": "Actin filament-associated protein 1-like 2; AFAP1-like protein 2", "protein_names_refseq": "AFAP1-like protein 2; actin filament-associated protein 1-like 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226250)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18034455;21183079;21750661;27029000;30084848;30820526", "class_list": "", "function": "May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We showed that XB130 might play protective roles in lipopolysaccharide-induced systemic septic response and acute lung injury, [RefSeq, PubMed]; XB130 acts as a tumor suppressor in carcinogen-induced skin tumorigenesis that may be mediated through inhibiting inflammation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BID1;Q8K2G0", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding;GO:0030296 protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007346 regulation of mitotic cell cycle;GO:0032675 regulation of interleukin-6 production;GO:0045893 positive regulation of DNA-templated transcription;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5DTU0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0H0-1", "uniprot_id": [ { "id": "ACOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0H0", "type": "external" } ], "mass": 74649.0, "length": 661, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 1", "gene_name": "Acox1", "organism": "Mouse", "refseq_name": "peroxisomal acyl-coenzyme A oxidase 1 isoform 2", "refseq_ac": [ { "id": "NP_001258827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258827", "type": "external" } ], "gene_names_uniprotkb": "Acox1; Acox; Paox", "gene_names_refseq": "AOX; Acox1; Acox; D130055E20Rik; Paox", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 1; 1.3.3.6; AOX; Palmitoyl-CoA oxidase; Peroxisomal fatty acyl-CoA oxidase; Straight-chain acyl-CoA oxidase", "protein_names_refseq": "palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1 isoform 2; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; peroxisomal fatty acyl-coenzyme A oxidase; peroxisomal straight-chain Acyl-CoA oxidase; straight-chain acyl-CoA oxidase", "tax_id": 10090, "disease": "peroxisomal acyl-CoA oxidase deficiency (Disease Ontology:DOID:0050797); Mitchell syndrome (Disease Ontology:DOID:0070516); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11430); (R-MMU-2046106); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10672038;11855929;17208939;20173027;20195242;21750661;23576753;23806337;25428506;25428507;30084848;30779550;34428180;36288343;37230398;37453647;37507081;37567517;38760332", "class_list": "", "function": "AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease., [RefSeq, PubMed]; Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (VLCFAs). Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes (By similarity). Involved in VLCFA-dependent hepatic-to-adipose tissue inter-organ signaling in response to diet. Through hepatic beta-oxidation of THA, may regulate THA systemic levels and THA-dependent activation of FFAR4 signaling in adipocytes, limiting adipose tissue thermogenesis (PubMed:38760332)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Is active against a much broader range of substrates and shows activity towards long-chain and very-long-chain fatty acyl-CoAs., [UniProtKB, UniProtKB]; Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro., [UniProtKB, UniProtKB]; This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]; Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A850;O35616;Q3TDG0;Q8BYC3", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.7.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.3.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003997 acyl-CoA oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0006629 lipid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9R0H0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHQ9-1", "uniprot_id": [ { "id": "ACO11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHQ9", "type": "external" } ], "mass": 67355.0, "length": 594, "protein_name": "Acyl-coenzyme A thioesterase 11", "gene_name": "Acot11", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 11 isoform 2", "refseq_ac": [ { "id": "NP_079866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079866", "type": "external" } ], "gene_names_uniprotkb": "Acot11; Bfit; Thea", "gene_names_refseq": "1110020M10Rik; 2010309H15Rik; Acot11; BFIT1; BFIT; Thea; Them1; mKIAA0707", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 11; 3.1.2.-; 3.1.2.2; Acyl-CoA thioester hydrolase 11; Acyl-CoA thioesterase 11; Adipose-associated thioesterase; BFIT; Brown fat-inducible thioesterase; Palmitoyl-coenzyme A thioesterase", "protein_names_refseq": "acyl-CoA thioester hydrolase 11; acyl-coenzyme A thioesterase 11 isoform 2; acyl-coenzyme A thioesterase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; palmitoyl-coenzyme A thioesterase; thioesterase, adipose associated", "tax_id": 10090, "disease": "", "pathway": " (mmu:329910); (R-MMU-77289)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11696000;21183079;21750661;29208699;31219806;34108467", "class_list": "", "function": "BFIT supports the transition of thermogenic brown adipose tissue towards increased metabolic activity, probably through alteration of intracellular fatty acyl-CoA concentration., [RefSeq, PubMed]; Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The liver-specific Them1 expression did not influence glucose tolerance or insulin sensitivity, but did promote hepatic gluconeogenesis in high-fat-fed animals., [RefSeq, PubMed]; Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0008289 lipid binding;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0016790 thiolester hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0009409 response to cold;GO:0035556 intracellular signal transduction;GO:0009266 response to temperature stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VHQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SWU9-1", "uniprot_id": [ { "id": "ACACA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SWU9", "type": "external" } ], "mass": 265257.0, "length": 2345, "protein_name": "Acetyl-CoA carboxylase 1", "gene_name": "Acaca", "organism": "Mouse", "refseq_name": "acetyl-CoA carboxylase 1", "refseq_ac": [ { "id": "NP_579938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579938", "type": "external" } ], "gene_names_uniprotkb": "Acaca; Acac; Gm738", "gene_names_refseq": "A530025K05Rik; Acaca; Acac; Acc1; Gm738", "protein_names_uniprotkb": "Acetyl-CoA carboxylase 1; 6.4.1.2; ACC-alpha; ACC1; Acetyl-CoA carboxylase 265", "protein_names_refseq": "ACC-alpha; acetyl-CoA carboxylase 1; acetyl-CoA carboxylase 265", "tax_id": 10090, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:107476); (R-MMU-196780); (R-MMU-200425); (R-MMU-75105)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "11907024;12360400;12668174;15607423;17208939;17242355;18630941;19131326;20457939;20952656;21183079;21750661;21987372;22454291;22645316;22872234;25050742;30018077;31010828;31219806;34418053;34428180;37507081;38640826", "class_list": "", "function": "A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis, [RefSeq, PubMed]; Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656)., [UniProtKB, PubMed]; MiR-24-3p enhances the Treg/Th17 balance to improve cerebral ischemic injury by suppressing acetyl-CoA carboxylase 1 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A6H4;Q5SWU6;Q5SWU7;Q5SWU8;Q6JIZ1;Q6PHL9;Q705X8;Q705X9;Q91VC8;Q925C4;Q925C5", "ec_number_list": [ { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0009374 biotin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0001650 fibrillar center", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008610 lipid biosynthetic process;GO:0051289 protein homotetramerization;GO:0055088 lipid homeostasis;GO:0001894 tissue homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q5SWU9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YE8-1", "uniprot_id": [ { "id": "SYNP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YE8", "type": "external" } ], "mass": 116527.0, "length": 1087, "protein_name": "Synaptopodin-2", "gene_name": "Synpo2", "organism": "Mouse", "refseq_name": "synaptopodin-2 isoform 2", "refseq_ac": [ { "id": "NP_001375431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001375431", "type": "external" } ], "gene_names_uniprotkb": "Synpo2", "gene_names_refseq": "1110069I04Rik; 2310068J10Rik; 9530006G20Rik; Myo; Synpo2", "protein_names_uniprotkb": "Synaptopodin-2; Myopodin", "protein_names_refseq": "myopodin; mypodin; synaptopodin-2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:118449)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11673475;15883195;16309678;17923693;21183079;21750661;30016717;34428180;34637763;37507081;39927985", "class_list": "", "function": "Has an actin-binding and actin-bundling activity (PubMed:11673475). Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor., [UniProtKB, UniProtKB, UniProtKB]; Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress., [RefSeq, PubMed]; The identification of myopodin as a direct target of PKA, CaMKII, and calcineurin defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C592", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051393 alpha-actinin binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0061684 chaperone-mediated autophagy;GO:0000045 autophagosome assembly;GO:0030335 positive regulation of cell migration;GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91YE8-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSL4-1", "uniprot_id": [ { "id": "ABR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSL4", "type": "external" } ], "mass": 97667.0, "length": 859, "protein_name": "Active breakpoint cluster region-related protein", "gene_name": "Abr", "organism": "Mouse", "refseq_name": "active breakpoint cluster region-related protein isoform 4", "refseq_ac": [ { "id": "NP_001278115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278115", "type": "external" } ], "gene_names_uniprotkb": "Abr", "gene_names_refseq": "Abr", "protein_names_uniprotkb": "Active breakpoint cluster region-related protein", "protein_names_refseq": "active breakpoint cluster region-related protein isoform 4; active breakpoint cluster region-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:109934); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "11921339;17116687;19144319;20962234;21183079;21750661;24058174;24960694;34428180;35820727;36210013;37507586;37828378", "class_list": "", "function": "Abr and Bcr play important complementary roles during vestibular morphogenesis, [RefSeq, PubMed]; Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase., [RefSeq, PubMed]; Loss of abr expression causes defects in spine development., [RefSeq, PubMed]; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; These results identify Abr-regulated CD4(+) T cell migration as an important component of severe cockroach allergen-evoked allergic asthma in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5G0;Q3UQJ6;Q3UY38;Q5SYJ5;Q5SYJ7;Q5SYJ8;Q5SYJ9;Q6PCY1;Q6PDH3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1905522 negative regulation of macrophage migration;GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0042472 inner ear morphogenesis;GO:0043312 neutrophil degranulation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5SSL4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYC0-1", "uniprot_id": [ { "id": "ADDA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYC0", "type": "external" } ], "mass": 80647.0, "length": 735, "protein_name": "Alpha-adducin", "gene_name": "Add1", "organism": "Mouse", "refseq_name": "alpha-adducin isoform 1", "refseq_ac": [ { "id": "NP_001019629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019629", "type": "external" } ], "gene_names_uniprotkb": "Add1", "gene_names_refseq": "Add1", "protein_names_uniprotkb": "Alpha-adducin; Erythrocyte adducin subunit alpha", "protein_names_refseq": "adducin 1 (alpha); alpha-adducin isoform 1; alpha-adducin; erythrocyte adducin subunit alpha", "tax_id": 10090, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hydrocephalus (Disease Ontology:DOID:10908); gastroschisis (Disease Ontology:DOID:11044); familial combined hyperlipidemia (Disease Ontology:DOID:13809); atherosclerosis (Disease Ontology:DOID:1936); cerebral palsy (Disease Ontology:DOID:1969); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:11518); (R-MMU-264870); (R-MMU-5223345)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10602987;10845937;15345747;16452087;17242355;21183079;21750661;22517741;22645316;25428507;25605945;28982183;32782141;32848054;33300544;33771994;34428180;34678516;35822049;36056066;39627609;40021952;40885482", "class_list": "", "function": "Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization. Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLE3", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0071300 cellular response to retinoic acid;GO:0045766 positive regulation of angiogenesis;GO:0000902 cell morphogenesis;GO:0006884 cell volume homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q9QYC0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28352-1", "uniprot_id": [ { "id": "APEX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P28352", "type": "external" } ], "mass": 35490.0, "length": 317, "protein_name": "DNA repair nuclease/redox regulator APEX1", "gene_name": "Apex1", "organism": "Mouse", "refseq_name": "DNA repair nuclease/redox regulator APEX1", "refseq_ac": [ { "id": "NP_033817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033817", "type": "external" } ], "gene_names_uniprotkb": "Apex1; Apex; Ape; Ref1", "gene_names_refseq": "APE; Apex1; Apex; HAP1; Ref-1", "protein_names_uniprotkb": "DNA repair nuclease/redox regulator APEX1; 3.1.11.2; 3.1.21.-; AP endonuclease 1; APEN; APEX nuclease; Apurinic-apyrimidinic endonuclease 1; REF-1; Redox factor-1", "protein_names_refseq": "AP endonuclease 1; APEN; APEX nuclease; DNA repair nuclease/redox regulator APEX1; DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase; redox factor-1", "tax_id": 10090, "disease": "spina bifida (Disease Ontology:DOID:0080016); urinary bladder cancer (Disease Ontology:DOID:11054); severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); cervix carcinoma (Disease Ontology:DOID:2893); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:11792); (R-MMU-110357); (R-MMU-110362); (R-MMU-110373); (R-MMU-5651801); (R-MMU-73930); (R-MMU-73933)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "12542794;16617147;1716153;18025127;1939131;19556307;20473298;21183079;21750661;23382073;31599954;34428180;35984892;37453647;37523789;38244516;7533013;7782087", "class_list": "", "function": "APE1 promotes embryonic stem cell proliferation and teratoma formation by regulating GDNF/GFRalpha1 axis., [RefSeq, PubMed]; Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy., [RefSeq, PubMed]; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (By similarity). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (By similarity). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (PubMed:18025127, PubMed:23382073). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (By similarity). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (By similarity). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (By similarity). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (By similarity). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (By similarity). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (By similarity). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (By similarity). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (By similarity). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.2.2.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.29", "type": "external" }, { "id": "3.2.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.27", "type": "external" }, { "id": "3.2.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.21", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.31", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P28352-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LR1-1", "uniprot_id": [ { "id": "ABD12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LR1", "type": "external" } ], "mass": 45270.0, "length": 398, "protein_name": "Lysophosphatidylserine lipase ABHD12", "gene_name": "Abhd12", "organism": "Mouse", "refseq_name": "lysophosphatidylserine lipase ABHD12 isoform 1", "refseq_ac": [ { "id": "NP_077785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077785", "type": "external" } ], "gene_names_uniprotkb": "Abhd12", "gene_names_refseq": "1500011G07Rik; 6330583M11Rik; Abhd12", "protein_names_uniprotkb": "Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; 3.1.-.-; 3.1.1.-; 3.1.1.23; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12", "protein_names_refseq": "2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; lysophosphatidylserine lipase ABHD12 isoform 1; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12", "tax_id": 10090, "disease": "PHARC syndrome (Disease Ontology:DOID:0080181)", "pathway": " (mmu:76192); (R-MMU-426048)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "18096503;20657592;21750661;23297193;25580854;27802388;28135057;28528544;30237167;30420694;30643283;30899004;32364701;32462874;33571455;37507081;37828378", "class_list": "", "function": "ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease., [RefSeq, PubMed]; Data reveal that 85% of brain 2-arachidonoylglycerol hydrolase activity can be ascribed to monoacylglycerol lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and ABHD12., [RefSeq, PubMed]; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ANB4;Q99M06", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0120560 phosphatidylserine lysophospholipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0046464 acylglycerol catabolic process;GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q99LR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIX8-1", "uniprot_id": [ { "id": "ACINU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIX8", "type": "external" } ], "mass": 150719.0, "length": 1338, "protein_name": "Apoptotic chromatin condensation inducer in the nucleus", "gene_name": "Acin1", "organism": "Mouse", "refseq_name": "apoptotic chromatin condensation inducer in the nucleus isoform 3", "refseq_ac": [ { "id": "NP_001078941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078941", "type": "external" } ], "gene_names_uniprotkb": "Acin1; Acinus", "gene_names_refseq": "2610036I19Rik; 2610510L13Rik; Acin1; Acinus; Acn; acinusL; acinusS; mKIAA0670", "protein_names_uniprotkb": "Apoptotic chromatin condensation inducer in the nucleus; Acinus", "protein_names_refseq": "apoptotic chromatin condensation inducer in the nucleus isoform 3; apoptotic chromatin condensation inducer in the nucleus", "tax_id": 10090, "disease": "", "pathway": " (mmu:56215); (R-MMU-111465); (R-MMU-72163)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10490026;17242355;18559500;18630941;19131326;19144319;21183079;21750661;23806337;26495903;29187734;34428180;39128105;39627609", "class_list": "", "function": "Analysis of the Upregulated Expression Mechanism of Apoptotic Chromatin Condensation Inducer 1 in Hepatocellular Carcinoma Based on Bioinformatics., [RefSeq, PubMed]; Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JJ87;Q9CSN7;Q9CSR9;Q9CSX7;Q9R046;Q9R047", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030218 erythrocyte differentiation;GO:0045657 positive regulation of monocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JIX8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW75-1", "uniprot_id": [ { "id": "AOFB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW75", "type": "external" } ], "mass": 58558.0, "length": 520, "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "Maob", "organism": "Mouse", "refseq_name": "amine oxidase [flavin-containing] B", "refseq_ac": [ { "id": "NP_766366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766366", "type": "external" } ], "gene_names_uniprotkb": "Maob", "gene_names_refseq": "6330414K01Rik; MAO-B; Maob", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] B; 1.4.3.21; 1.4.3.4; MAO-B; Monoamine oxidase type B", "protein_names_refseq": "amine oxidase [flavin-containing] B; monoamine oxidase type B", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:109731); (R-MMU-141333)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23576753;30084848;31219806;33300544;34428180;34996979;36416117;37047416;37225849;37453647;37507081;4156831", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:4156831). Preferentially degrades benzylamine and phenylethylamine (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice., [RefSeq, PubMed]; Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation., [RefSeq, PubMed]; Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14CG9;Q8C0B2", "ec_number_list": [ { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0014063 negative regulation of serotonin secretion;GO:0042428 serotonin metabolic process;GO:0045964 positive regulation of dopamine metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BW75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVM7-1", "uniprot_id": [ { "id": "FACC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVM7", "type": "external" } ], "mass": 44916.0, "length": 383, "protein_name": "Flagellum-associated coiled-coil domain-containing protein 1", "gene_name": "Flacc1", "organism": "Mouse", "refseq_name": "flagellum-associated coiled-coil domain-containing protein 1 isoform b", "refseq_ac": [ { "id": "NP_780579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780579", "type": "external" } ], "gene_names_uniprotkb": "Flacc1; Als2cr12", "gene_names_refseq": "4933405P16Rik; 4933425F06Rik; Als2cr12; Flacc1", "protein_names_uniprotkb": "Flagellum-associated coiled-coil domain-containing protein 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog", "protein_names_refseq": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog; amyotrophic lateral sclerosis 2 chromosome region 12; flagellum-associated coiled-coil domain-containing protein 1 isoform b; flagellum-associated coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:108812)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21402173;21750661;33156557", "class_list": "", "function": "FLACC1 is testis-specific but dispensable for fertility in mice. GeneRIF: FLACC1 is dispensable for viability and fertility in mouse., [RefSeq, PubMed]; The expression of the Als2cr12 gene at the transcriptional, protein and cellular levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0036126 sperm flagellum;GO:0035686 sperm fibrous sheath", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BVM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZD8-1", "uniprot_id": [ { "id": "AMGO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZD8", "type": "external" } ], "mass": 55343.0, "length": 492, "protein_name": "Amphoterin-induced protein 1", "gene_name": "Amigo1", "organism": "Mouse", "refseq_name": "amphoterin-induced protein 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001004293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004293", "type": "external" } ], "gene_names_uniprotkb": "Amigo1; Ali2; Amigo; Kiaa1163", "gene_names_refseq": "Amigo1; Amigo; ali2", "protein_names_uniprotkb": "Amphoterin-induced protein 1; AMIGO-1; Alivin-2", "protein_names_refseq": "AMIGO-1; alivin 2; amphoterin induced gene and ORF (Amigo); amphoterin-induced protein 1 isoform a precursor; amphoterin-induced protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229715)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12629050;21183079;21750661;21983541;22056818;30084848;30779550;30899004", "class_list": "", "function": "Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:22056818)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AE40;Q69ZQ0;Q8R5D4;Q921U9", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0042552 myelination;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80ZD8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WG5-1", "uniprot_id": [ { "id": "AAKG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WG5", "type": "external" } ], "mass": 62949.0, "length": 566, "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "Prkag2", "organism": "Mouse", "refseq_name": "5'-AMP-activated protein kinase subunit gamma-2 isoform 3", "refseq_ac": [ { "id": "NP_001164027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164027", "type": "external" } ], "gene_names_uniprotkb": "Prkag2", "gene_names_refseq": "2410051C13Rik; AAKG2; AAKG; H91620p; Prkag2; WPWS", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma-2; AMPK gamma2; AMPK subunit gamma-2", "protein_names_refseq": "5'-AMP-activated protein kinase subunit gamma-2 isoform 3; 5'-AMP-activated protein kinase subunit gamma-2; AMPK gamma-2 chain; AMPK subunit gamma-2", "tax_id": 10090, "disease": "lethal congenital glycogen storage disease of heart (Disease Ontology:DOID:0090101); hypertrophic cardiomyopathy 6 (Disease Ontology:DOID:0110312); neurodegenerative disease (Disease Ontology:DOID:1289); glycogen storage disease (Disease Ontology:DOID:2747); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384)", "pathway": " (mmu:108099); (R-MMU-1632852); (R-MMU-163680); (R-MMU-200425); (R-MMU-380972); (R-MMU-5628897); (R-MMU-6804756); (R-MMU-9931269)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "16675525;17242355;17301033;17597581;21183079;21460634;21750661;25605945;29097735", "class_list": "", "function": "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive., [UniProtKB, UniProtKB]; CNTF(Ax15) bypasses diet-induced leptin resistance to reduce hypothalamic AMPK activity, [RefSeq, PubMed]; CR resulted in incerasd AMPK phosphorylation and, hence, activation. GHR knockout animals also exhibited invrease p-AMPK levels. P-AMPK levels were not altered by disruption of the GHR gene., [RefSeq, PubMed]; Despite high glycogen content, the TGT400N heart is not protected against ischemia-reperfusion injury., [RefSeq, PubMed]; Gamma2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemmal Ca(2+) release. In contrast, loss of gamma2 AMPK induces a reciprocal phenotype of increased heart rate, and prevents the adaptive intrinsic bradycardia of endurance training. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QK80;Q6V7V5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004679 AMP-activated protein kinase activity;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0035556 intracellular signal transduction;GO:0005977 glycogen metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0019217 regulation of fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91WG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBL1-1", "uniprot_id": [ { "id": "ACDSB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBL1", "type": "external" } ], "mass": 47874.0, "length": 432, "protein_name": "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadsb", "organism": "Mouse", "refseq_name": "short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_080102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080102", "type": "external" } ], "gene_names_uniprotkb": "Acadsb", "gene_names_refseq": "1300003O09Rik; 2-MEBCAD; Acadsb; SBCAD", "protein_names_uniprotkb": "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.5; 2-MEBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; SBCAD", "protein_names_refseq": "2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:66885); (R-MMU-70895); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;23576753;23806337;30084848;33920575;34428180;37507081;39927985", "class_list": "", "function": "LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p. Publication Status: Online-Only, [RefSeq, PubMed]; Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0009055 electron transfer activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006637 acyl-CoA metabolic process;GO:0006550 L-isoleucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DBL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08785-1", "uniprot_id": [ { "id": "CLOCK_MOUSE", "url": "https://www.uniprot.org/uniprot/O08785", "type": "external" } ], "mass": 96393.0, "length": 855, "protein_name": "Circadian locomoter output cycles protein kaput", "gene_name": "Clock", "organism": "Mouse", "refseq_name": "circadian locomoter output cycles protein kaput isoform 1", "refseq_ac": [ { "id": "NP_001276755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276755", "type": "external" } ], "gene_names_uniprotkb": "Clock", "gene_names_refseq": "5330400M04Rik; Clock; KAT13D", "protein_names_uniprotkb": "Circadian locomoter output cycles protein kaput; 2.3.1.48; mCLOCK", "protein_names_refseq": "circadian locomoter output cycles protein kaput isoform 1; circadian locomoter output cycles protein kaput; circadian locomotor output cycles kaput", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); cholestasis (Disease Ontology:DOID:13580); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:12753)", "pathway_count": 1, "publication_count": 74, "publication_id_list": "11116088;11779462;12738229;12897057;14645221;14672706;16678094;16717091;16980631;17242355;17310242;17417633;18075593;18316400;18430226;18662546;18662547;19129230;19141540;19286518;19299583;19414601;19605937;19946213;20385766;20430893;20562852;20658528;20861012;20956306;21113167;21750661;21768648;21930935;21960634;22284746;22653727;22895791;22900038;22981862;23160374;23291174;23303907;23395175;23395176;23576606;23756047;23785138;23916625;24043798;24089055;24154698;24235147;24270424;24333415;24378737;24385426;24395244;24442997;24529706;28903391;28985504;29937374;30012868;32782141;34428180;35822049;38734687;38805270;40885482;40997131;9160755;9160756;9616112", "class_list": "", "function": "Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells., [RefSeq, PubMed]; The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner (By similarity). Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (PubMed:30012868)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.12", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051775 response to redox state", "synthesized_glycan_count": 0, "hit_score": 7.8, "record_id": "O08785-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63101-1", "uniprot_id": [ { "id": "1433Z_MOUSE", "url": "https://www.uniprot.org/uniprot/P63101", "type": "external" } ], "mass": 27771.0, "length": 245, "protein_name": "14-3-3 protein zeta/delta", "gene_name": "Ywhaz", "organism": "Mouse", "refseq_name": "14-3-3 protein zeta/delta isoform 1", "refseq_ac": [ { "id": "NP_001240734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240734", "type": "external" } ], "gene_names_uniprotkb": "Ywhaz", "gene_names_refseq": "1110013I11Rik; 14-3-3zeta; Ywhaz", "protein_names_uniprotkb": "14-3-3 protein zeta/delta; KCIP-1; Protein kinase C inhibitor protein 1; SEZ-2", "protein_names_refseq": "14-3-3 protein zeta/delta isoform 1; 14-3-3 protein zeta/delta; 14-3-3 zeta; KCIP-1; SEZ-2; protein kinase C inhibitor protein 1", "tax_id": 10090, "disease": "absence epilepsy (Disease Ontology:DOID:0070309); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:22631); (R-MMU-111447); (R-MMU-3769402); (R-MMU-392517); (R-MMU-430116); (R-MMU-450604); (R-MMU-512988); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-75035); (R-MMU-9013700); (R-MMU-9614399)", "pathway_count": 12, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10455159;12176995;15345747;16075062;16959763;19218246;20478393;21183079;21189996;21478148;21750661;22645316;22701344;24788674;25428506;25605945;26047703;26452228;26740625;31076568;33300544;33725478;34203471;34260942;34428180;36288343;37453647;37507081;38908751;39927985;8645260;9016762;9197417;9705322", "class_list": "", "function": "14-3-3zeta suppresses RANKL signaling by destabilizing TRAF6., [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P35215;P70197;P97286;Q3TSF1;Q5EBQ1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0003016 respiratory system process;GO:0006468 protein phosphorylation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P63101-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHY3-1", "uniprot_id": [ { "id": "ANO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHY3", "type": "external" } ], "mass": 110916.0, "length": 960, "protein_name": "Anoctamin-1", "gene_name": "Ano1", "organism": "Mouse", "refseq_name": "anoctamin-1 isoform 2", "refseq_ac": [ { "id": "NP_001229278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229278", "type": "external" } ], "gene_names_uniprotkb": "Ano1; Tmem16a", "gene_names_refseq": "Ano1; Tmem16a", "protein_names_uniprotkb": "Anoctamin-1; Transmembrane protein 16A", "protein_names_refseq": "anoctamin-1 isoform 2; anoctamin-1; transmembrane protein 16A", "tax_id": 10090, "disease": "Moyamoya disease (Disease Ontology:DOID:13099)", "pathway": " (mmu:101772); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "18585372;18724360;18729231;20056604;21750661;22002868;22075693;22634729;23021219;23840801;24509911;24913262;25779870;28561733;28963502;29236684;29236691;29928889;30084848;30586313;31147466;31175367;33378669;34089532;34428180;34433575;35129434;35135993;39097775;39495104", "class_list": "", "function": "Calcium-activated chloride channel (CaCC) (PubMed:18724360, PubMed:22002868, PubMed:22634729, PubMed:23840801, PubMed:24913262, PubMed:25779870, PubMed:28561733, PubMed:28963502, PubMed:29236684, PubMed:29236691, PubMed:31147466, PubMed:34089532, PubMed:34433575, PubMed:35135993). Plays a role in transepithelial anion transport and smooth muscle contraction (PubMed:28561733, PubMed:29236684, PubMed:29236691). Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (By similarity). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (PubMed:30586313). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (By similarity). However, was shown in another study not to be required for MUC5AC expression (By similarity). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (PubMed:35129434). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (PubMed:34433575). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (PubMed:34089532). Acts as a heat sensor in nociceptive neurons (PubMed:22634729). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G protein-coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (PubMed:35135993). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (PubMed:31147466)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study reports that all mice homozygous for a null allele of Tmem16a died within one month of birth and exhibited severe tracheomalacia with gaps in the tracheal cartilage rings along the entire length of the trachea., [RefSeq, PubMed]; TMEM16A regulates satellite cell-mediated skeletal muscle regeneration by ensuring a moderate level of caspase 3 activity., [RefSeq, PubMed]; Transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride channel that is activated by intracellular Ca(2+) and Ca(2+)-mobilizing stimuli, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 49, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5C6;Q8BI26;Q99JK1", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005227 calcium-activated cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0034605 cellular response to heat;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0070254 mucus secretion", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8BHY3-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR21-1", "uniprot_id": [ { "id": "ACPM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR21", "type": "external" } ], "mass": 17370.0, "length": 156, "protein_name": "Acyl carrier protein, mitochondrial", "gene_name": "Ndufab1", "organism": "Mouse", "refseq_name": "acyl carrier protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_082453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082453", "type": "external" } ], "gene_names_uniprotkb": "Ndufab1", "gene_names_refseq": "2210401F17Rik; 2310039H15Rik; 2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; Ndufab1; SDAP", "protein_names_uniprotkb": "Acyl carrier protein, mitochondrial; ACP; CI-SDAP; NADH-ubiquinone oxidoreductase 9.6 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1; NADH-ubiquinone oxidoreductase 9.6 kDa subunit; acyl carrier protein, mitochondrial precursor; acyl carrier protein, mitochondrial", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (mmu:70316); (R-MMU-611105); (R-MMU-6799198); (R-MMU-77289); (R-MMU-9857492); (R-MMU-9937383)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "16479539;21750661;23576753;25605945;31530015;32152506;34203471;34428180;38575788", "class_list": "", "function": "Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:38575788). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Carrier of the growing fatty acid chain in fatty acid biosynthesis., [UniProtKB, UniProtKB, UniProtKB]; Skeletal muscle-specific ablation of NDUFAB1 disrupts glucose homeostasis and results in obesity and insulin resistance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D726;Q9D7V5", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0000035 acyl binding;GO:0000036 acyl carrier activity;GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0009249 protein lipoylation;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CR21-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08715-1", "uniprot_id": [ { "id": "AKAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08715", "type": "external" } ], "mass": 92195.0, "length": 857, "protein_name": "A-kinase anchor protein 1, mitochondrial", "gene_name": "Akap1", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 1, mitochondrial", "refseq_ac": [ { "id": "NP_001036006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036006", "type": "external" } ], "gene_names_uniprotkb": "Akap1; Akap", "gene_names_refseq": "AKAP121; AKAP84; Akap1; Akap; DAKAP1; S-AKAP84", "protein_names_uniprotkb": "A-kinase anchor protein 1, mitochondrial; D-AKAP-1; Dual specificity A-kinase-anchoring protein 1; PRKA1; Protein kinase A-anchoring protein 1; S-AKAP; Spermatid A-kinase anchor protein", "protein_names_refseq": "A kinase (PRKA) anchor protein 1; A-kinase anchor protein 1, mitochondrial; D-AKAP-1; PRKA1; S-AKAP; a kinase anchor protein 1, mitochondrial; dual specificity A-kinase-anchoring protein 1; protein kinase A-anchoring protein 1; spermatid A-kinase anchor protein", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:11640); (R-MMU-983231)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10352013;17242355;18630941;20173027;21183079;21750661;24101730;28528544;31219806;32072193;32312949;32848054;34428180;36288343;36852467;38286648;40885482;9065479;9182549", "class_list": "", "function": "AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte. Publication Status: Online-Only, [RefSeq, PubMed]; Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis., [RefSeq, PubMed]; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A (PubMed:9065479, PubMed:9182549). Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum (PubMed:9065479, PubMed:9182549). Involved in mitochondrial-mediated antiviral innate immunity (By similarity). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (PubMed:32072193). Under diabetic conditions, myocardial AKAP1 expression decreases which blocks the translocation of NDUFS1 from the cytosol to mitochondria (PubMed:32072193). Reduction of NDUFS1 in mitochondria decreases ATP production and increases mitochondrial ROS level, which causes mitochondrial dysfunction and cell apoptosis, respectively, thereby leading to cardiac dysfunction (PubMed:32072193)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AR25;O08714;P97488", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0006915 apoptotic process;GO:0042308 negative regulation of protein import into nucleus;GO:0035305 negative regulation of dephosphorylation;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O08715-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TCJ1-1", "uniprot_id": [ { "id": "ABRX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TCJ1", "type": "external" } ], "mass": 46943.0, "length": 415, "protein_name": "BRISC complex subunit Abraxas 2", "gene_name": "Abraxas2", "organism": "Mouse", "refseq_name": "BRISC complex subunit Abraxas 2", "refseq_ac": [ { "id": "NP_932134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932134", "type": "external" } ], "gene_names_uniprotkb": "Abraxas2; Abro1; Fam175b; Kiaa0157", "gene_names_refseq": "Abraxas2; Abro1; C430003P19Rik; Fam175b", "protein_names_uniprotkb": "BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B", "protein_names_refseq": "BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; abraxas brother protein 1; family with sequence similarity 175, member B", "tax_id": 10090, "disease": "", "pathway": " (mmu:109359); (R-MMU-5689901)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21195082;21750661;22974638;24075985;25428506;26344097;30084848;30779550;34428180;35820727", "class_list": "", "function": "Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (PubMed:21195082). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Data shows that the expression of Abro1 protein substantially increased (at least three-fold) in the hearts of mice that underwent MI/R compared to sham operated controls., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB08;Q8K0R4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0002931 response to ischemia;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3TCJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47738-1", "uniprot_id": [ { "id": "ALDH2_MOUSE", "url": "https://www.uniprot.org/uniprot/P47738", "type": "external" } ], "mass": 56538.0, "length": 519, "protein_name": "Aldehyde dehydrogenase, mitochondrial", "gene_name": "Aldh2", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_033786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033786", "type": "external" } ], "gene_names_uniprotkb": "Aldh2; Ahd-1; Ahd1", "gene_names_refseq": "AHD-M1; ALDH-E2; ALDHI; Ahd-5; Ahd5; Aldh2", "protein_names_uniprotkb": "Aldehyde dehydrogenase, mitochondrial; 1.2.1.3; AHD-M1; ALDH class 2; ALDH-E2; ALDHI", "protein_names_refseq": "ALDH class 2; aldehyde dehydrogenase, mitochondrial isoform 1 precursor; aldehyde dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); brain infarction (Disease Ontology:DOID:3454); liver disease (Disease Ontology:DOID:409); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:11669); (R-MMU-380612); (R-MMU-71384); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "21750661;23576753;23806337;26740625;28528544;29562282;31219806;32152506;33300544;34428180;36288343;37453647;37507081;38777148;39927985;40684658;7937138;7958964;8058062", "class_list": "", "function": "Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts., [RefSeq, PubMed]; Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0070404 NADH binding;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0048149 behavioral response to ethanol;GO:0006068 ethanol catabolic process;GO:2000377 regulation of reactive oxygen species metabolic process;GO:0046185 aldehyde catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P47738-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31230-1", "uniprot_id": [ { "id": "AIMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P31230", "type": "external" } ], "mass": 33997.0, "length": 310, "protein_name": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "gene_name": "Aimp1", "organism": "Mouse", "refseq_name": "aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001355555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355555", "type": "external" } ], "gene_names_uniprotkb": "Aimp1; Emap2; Scye1", "gene_names_refseq": "9830137A06Rik; AIMP1/p43; Aimp1; EMAPII; Emap2; Scye1; p43", "protein_names_uniprotkb": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; EMAP-II; Endothelial monocyte-activating polypeptide II; Multisynthase complex auxiliary component p43; Small inducible cytokine subfamily E member 1", "protein_names_refseq": "ARS inducible multifunctional protein 1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform 2; aminoacyl tRNA synthase complex-interacting multifunctional protein 1; endothelial monocyte activating polypeptide 2; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; small inducible cytokine subfamily E, member 1", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 3 (Disease Ontology:DOID:0060790); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:13722); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;11306575;12060739;1400342;15681823;17001013;17525271;18292511;18448069;20173027;21750661;22517741;22645316;22826440;23806337;25153642;28528544;30016717;30059200;31962335;32579851;32771459;32782141;32848054;33003470;34428180;35984892;36288343;39927985;40021952;40885482;7545917;7929199;9770485", "class_list": "", "function": "Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development., [RefSeq, PubMed]; Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells., [RefSeq, PubMed]; Non-catalytic component of the multisynthase complex (PubMed:12060739). Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (By similarity). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:1400342, PubMed:7545917). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (PubMed:18448069). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (PubMed:17001013). Promotes dermal fibroblast proliferation and wound repair (PubMed:15681823). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (PubMed:17525271). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelial cell apoptosis at high concentrations (By similarity). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:18292511). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The Role of the AIMP1 Pathway in Diabetic Retinopathy: AIMP1-Targeted Intervention Study in Diabetic Retinopathy., [RefSeq, PubMed]; Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q60659", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding;GO:0005125 cytokine activity;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0007267 cell-cell signaling;GO:0006915 apoptotic process;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P31230-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKW0-1", "uniprot_id": [ { "id": "AR6P1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKW0", "type": "external" } ], "mass": 23437.0, "length": 203, "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 1", "gene_name": "Arl6ip1", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 6-interacting protein 1", "refseq_ac": [ { "id": "NP_062292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062292", "type": "external" } ], "gene_names_uniprotkb": "Arl6ip1; Arl6ip", "gene_names_refseq": "AIP-6; ARMER; Aip-1; Arl6ip1; Arl6ip; mKIAA0069", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6-interacting protein 1; ARL-6-interacting protein 1; Aip-1; Protein TBX2", "protein_names_refseq": "ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation-like factor 6 interacting protein; ARL-6-interacting protein 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 61 (Disease Ontology:DOID:0110812); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:54208)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10508919;10995579;18299400;18684713;21750661;21952136;25428506;25605945;30084848;34428180;37216506;37934410", "class_list": "", "function": "ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model., [RefSeq, PubMed]; ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation., [RefSeq, PubMed]; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (PubMed:18684713). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLI9;Q9WUG3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0002038 positive regulation of L-glutamate import across plasma membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0071787 endoplasmic reticulum tubular network formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JKW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55096-1", "uniprot_id": [ { "id": "ABCD3_MOUSE", "url": "https://www.uniprot.org/uniprot/P55096", "type": "external" } ], "mass": 75475.0, "length": 659, "protein_name": "ATP-binding cassette sub-family D member 3", "gene_name": "Abcd3", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family D member 3 isoform 1", "refseq_ac": [ { "id": "NP_033017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033017", "type": "external" } ], "gene_names_uniprotkb": "Abcd3; Pmp70; Pxmp1", "gene_names_refseq": "Abcd3; PMP68; PMP70; Pxmp1", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 3; 3.1.2.-; 68 kDa peroxisomal membrane protein; 7.6.2.-; 70 kDa peroxisomal membrane protein; PMP68; PMP70", "protein_names_refseq": "68 kDa peroxisomal membrane protein; 70 kDa peroxisomal membrane protein; ATP-binding cassette sub-family D member 3 isoform 1; ATP-binding cassette, sub-family D (ALD), member 3; peroxisomal membrane protein 1; peroxisomal membrane protein, 70 kDa", "tax_id": 10090, "disease": "congenital bile acid synthesis defect 5 (Disease Ontology:DOID:0111066); adrenoleukodystrophy (Disease Ontology:DOID:10588); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (mmu:19299); (R-MMU-1369062); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9603798)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "17208939;17242355;21750661;22872234;23576753;25168382;25428506;28315936;30084848;31219806;33300544;34203471;34428180;35820727;36210013;37453647;37507081;7544098;7551822", "class_list": "", "function": "Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities (By similarity). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:25168382)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0006869 lipid transport;GO:0042760 very long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P55096-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70174-1", "uniprot_id": [ { "id": "ACHA4_MOUSE", "url": "https://www.uniprot.org/uniprot/O70174", "type": "external" } ], "mass": 70305.0, "length": 629, "protein_name": "Neuronal acetylcholine receptor subunit alpha-4", "gene_name": "Chrna4", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_056545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056545", "type": "external" } ], "gene_names_uniprotkb": "Chrna4; Acra4", "gene_names_refseq": "Acra-4; Acra4; Chrna4; EBN1; ENFL1", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-4", "protein_names_refseq": "a4 nicotinic receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; alpha4 nAChR; neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor; neuronal acetylcholine receptor subunit alpha-4", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autosomal dominant nocturnal frontal lobe epilepsy 1 (Disease Ontology:DOID:0060682); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); alcohol use disorder (Disease Ontology:DOID:1574); congenital myasthenic syndrome (Disease Ontology:DOID:3635); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:11438); (R-MMU-629587); (R-MMU-629594); (R-MMU-629597)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11434511;12944511;21183079;21750661;35820727;9749753", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (By similarity). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (By similarity). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (PubMed:12944511)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHE9;Q8VI10;Q9ET51", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O70174-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45952-1", "uniprot_id": [ { "id": "ACADM_MOUSE", "url": "https://www.uniprot.org/uniprot/P45952", "type": "external" } ], "mass": 46481.0, "length": 421, "protein_name": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadm", "organism": "Mouse", "refseq_name": "medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031408", "type": "external" } ], "gene_names_uniprotkb": "Acadm", "gene_names_refseq": "Acadm; MCAD", "protein_names_uniprotkb": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; MCAD", "protein_names_refseq": "medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "medium chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080153); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:11364); (R-MMU-77288); (R-MMU-77346); (R-MMU-77348)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "1438358;16121256;21183079;21750661;23576753;23806337;34428180;36288343;37453647;37507081;39927985;7829081", "class_list": "", "function": "Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:16121256). The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:16121256). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16 (PubMed:16121256)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64235", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030424 axon;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001889 liver development;GO:0006635 fatty acid beta-oxidation;GO:0007507 heart development;GO:0009409 response to cold;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P45952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K009-1", "uniprot_id": [ { "id": "AL1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K009", "type": "external" } ], "mass": 101590.0, "length": 923, "protein_name": "Mitochondrial 10-formyltetrahydrofolate dehydrogenase", "gene_name": "Aldh1l2", "organism": "Mouse", "refseq_name": "mitochondrial 10-formyltetrahydrofolate dehydrogenase", "refseq_ac": [ { "id": "NP_705771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705771", "type": "external" } ], "gene_names_uniprotkb": "Aldh1l2", "gene_names_refseq": "Aldh1l2; D330038I09Rik; mtFDH", "protein_names_uniprotkb": "Mitochondrial 10-formyltetrahydrofolate dehydrogenase; 1.5.1.6; Aldehyde dehydrogenase family 1 member L2; Mitochondrial 10-FTHFDH; mtFDH", "protein_names_refseq": "aldehyde dehydrogenase 1L2; aldehyde dehydrogenase family 1 member L2, mitochondrial; mitochondrial 10-FTHFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:216188); (R-MMU-196757)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;23806337;25428506;30084848;33168096;34428180;35820727;37507016;37828378;38923573", "class_list": "", "function": "Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil., [RefSeq, PubMed]; Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder. Publication Status: Online-Only, [RefSeq, PubMed]; FOXO1 induced fatty acid oxidation in hepatic cells by targeting ALDH1L2., [RefSeq, PubMed]; Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLV8", "ec_number_list": [ { "id": "1.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0016155 formyltetrahydrofolate dehydrogenase activity;GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006730 one-carbon metabolic process;GO:0009258 10-formyltetrahydrofolate catabolic process;GO:0046655 folic acid metabolic process;GO:0006740 NADPH regeneration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K009-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXD1-1", "uniprot_id": [ { "id": "ACOX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXD1", "type": "external" } ], "mass": 76863.0, "length": 681, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 2", "gene_name": "Acox2", "organism": "Mouse", "refseq_name": "peroxisomal acyl-coenzyme A oxidase 2", "refseq_ac": [ { "id": "NP_001155139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155139", "type": "external" } ], "gene_names_uniprotkb": "Acox2", "gene_names_refseq": "Acox2; THCCox", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 2; 1.3.3.6; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Branched-chain acyl-CoA oxidase 2; THCA-CoA oxidase; THCCox; Trihydroxycoprostanoyl-CoA oxidase", "protein_names_refseq": "3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; THCA-CoA oxidase; branched chain acyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 2; trihydroxycoprostanoyl-CoA oxidase", "tax_id": 10090, "disease": "Mitchell syndrome (Disease Ontology:DOID:0070516); congenital bile acid synthesis defect 6 (Disease Ontology:DOID:0111067)", "pathway": " (mmu:93732); (R-MMU-193368); (R-MMU-389887); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;23806337;31616917;34428180;40963015", "class_list": "", "function": "Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs) and bile acids intermediates. Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product. Oxidizes its substrates in a stereospecific way and can only desaturate isomers carrying (2S)-methyl groups (PubMed:40963015). In brown adipose tissue peroxisomes, mediates beta-oxidation of monomethyl branched-chain fatty acids with iso configuration (mmBCFAs) as part of a substrate synthesis and oxidation cycle fueled by FASN-dependent de novo mmBCFA synthesis. The mmBCFA catabolism is coupled to AMPK activation and mitochondrial ATP production as a thermogenic adaptation mechanism to maintain the body temperature in cold environment (PubMed:40963015). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3 (By similarity). In the liver, mediates side-chain beta-oxidation of C27 bile acyl-CoA intermediates carrying a (25S)-methyl group to yield 24,25-trans unsaturated derivatives as part of peroxisomal bile acid synthesis pathway (By similarity). Can oxidize straight-chain fatty acyl CoAs such as C10-CoA and C16-CoA with low efficiency (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCB0", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXD1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02152-1", "uniprot_id": [ { "id": "5HT2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02152", "type": "external" } ], "mass": 53597.0, "length": 479, "protein_name": "5-hydroxytryptamine receptor 2B", "gene_name": "Htr2b", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 2B", "refseq_ac": [ { "id": "NP_032337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032337", "type": "external" } ], "gene_names_uniprotkb": "Htr2b", "gene_names_refseq": "5-HT-2B; 5-HT-2F; 5-HT2B; Htr2b", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT-2F; 5-HT2B; NP75 protein; Serotonin receptor 2B", "protein_names_refseq": "5-hydroxytryptamine receptor 2B; NP75 protein; serotonin receptor 2B", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); brain infarction (Disease Ontology:DOID:3454); heart valve disease (Disease Ontology:DOID:4079); congestive heart failure (Disease Ontology:DOID:6000); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:15559); (R-MMU-390666); (R-MMU-416476)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10944220;11413089;11471062;12244304;12738797;1426253;16940156;17325130;17846081;18337424;19941613;21179162;21273425;21750661;23346101;38381131", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1426253, PubMed:17325130). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:1426253, PubMed:16940156). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (PubMed:16940156, PubMed:18337424). May play a role in the perception of pain (PubMed:21273425). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (PubMed:10944220, PubMed:11413089). Protects cardiomyocytes against apoptosis (PubMed:12738797). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (PubMed:12244304). Plays a role in vasoconstriction (PubMed:12244304, PubMed:23346101). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (PubMed:17846081). Required for normal proliferation of the interstitial cells of Cajal in the intestine (PubMed:19941613)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZK5;Q9QWS2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0019722 calcium-mediated signaling;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q02152-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76MZ3-1", "uniprot_id": [ { "id": "2AAA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q76MZ3", "type": "external" } ], "mass": 65323.0, "length": 589, "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "gene_name": "Ppp2r1a", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "refseq_ac": [ { "id": "NP_058587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058587", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r1a", "gene_names_refseq": "6330556D22Rik; PP2Aa; PP2A; PR65; Ppp2r1a", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PP2Aa", "protein_names_refseq": "protein phosphatase PP2A; serine/threonine protein phosphatase A subunit type 2A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 36 (Disease Ontology:DOID:0070066)", "pathway": " (mmu:51792); (R-MMU-113501); (R-MMU-1295596); (R-MMU-141430); (R-MMU-141444); (R-MMU-180024); (R-MMU-195253); (R-MMU-196299); (R-MMU-198753); (R-MMU-202670); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-2995383); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6804757); (R-MMU-6811558); (R-MMU-68877); (R-MMU-69231); (R-MMU-69273); (R-MMU-8854518); (R-MMU-9648025); (R-MMU-975957); (R-MMU-9833482); (R-MMU-9860927)", "pathway_count": 36, "publication_count": 32, "publication_id_list": "10100624;11665638;16258073;18250455;18299400;20173027;21750661;22417654;22466704;22645316;23806337;25153642;25428506;25605945;26740625;26974206;28528544;30084848;30611118;30779550;33300544;33505023;34428180;34887587;35405096;35820727;37453647;37507081;37828378;39627609;39927985;40684658", "class_list": "", "function": "Protein phosphatase 2A overexpression in NIH 3T3 cells, [RefSeq, PubMed]; Protein phosphatase 2A regulates cytotoxicity and drug resistance by dephosphorylating AHR and MDR1., [RefSeq, PubMed]; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:10100624, PubMed:26974206). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26974206, PubMed:33505023). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (PubMed:33505023). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (By similarity). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity). Regulates the recruitment of the SKA complex to kinetochores (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0019888 protein phosphatase regulator activity;GO:1990405 protein antigen binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0007059 chromosome segregation;GO:0070262 peptidyl-serine dephosphorylation;GO:0006366 transcription by RNA polymerase II;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q76MZ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41233-1", "uniprot_id": [ { "id": "ABCA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P41233", "type": "external" } ], "mass": 253912.0, "length": 2261, "protein_name": "Phospholipid-transporting ATPase ABCA1", "gene_name": "Abca1", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase ABCA1", "refseq_ac": [ { "id": "NP_038482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038482", "type": "external" } ], "gene_names_uniprotkb": "Abca1; Abc1", "gene_names_refseq": "ABC-1; Abc1; Abca1", "protein_names_uniprotkb": "Phospholipid-transporting ATPase ABCA1; 7.6.2.1; ABC-1; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1", "protein_names_refseq": "ATP-binding cassette 1; ATP-binding cassette transporter 1; ATP-binding cassette, sub-family A (ABC1), member 1; phospholipid-transporting ATPase ABCA1", "tax_id": 10090, "disease": "primary hypoalphalipoproteinemia 1 (Disease Ontology:DOID:0080957); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); membranous glomerulonephritis (Disease Ontology:DOID:10976); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); extrahepatic cholestasis (Disease Ontology:DOID:13619); hypolipoproteinemia (Disease Ontology:DOID:1387); Tangier disease (Disease Ontology:DOID:1388); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11303); (R-MMU-8963896); (R-MMU-9029569)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11352567;12032171;12196520;12777468;17205124;17242355;19349973;21183079;25428506;26495903;30084848;30899004;31599954;32152506;34428180;8088782", "class_list": "", "function": "Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain., [UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 17, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "B1AWZ8", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0034185 apolipoprotein binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0051117 ATPase binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P41233-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58137-1", "uniprot_id": [ { "id": "ACOT8_MOUSE", "url": "https://www.uniprot.org/uniprot/P58137", "type": "external" } ], "mass": 35827.0, "length": 320, "protein_name": "Acyl-coenzyme A thioesterase 8", "gene_name": "Acot8", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 8 isoform 1", "refseq_ac": [ { "id": "NP_573503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573503", "type": "external" } ], "gene_names_uniprotkb": "Acot8; Pte1", "gene_names_refseq": "Acot8; PTE-1; PTE-2; Pte1", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 8; 3.1.2.11; 3.1.2.1; 3.1.2.27; 3.1.2.2; 3.1.2.3; 3.1.2.5; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; PTE-1; PTE-2; Peroxisomal acyl-CoA thioesterase 2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long-chain acyl-CoA thioesterase 1", "protein_names_refseq": "acyl-coenzyme A thioesterase 8 isoform 1; acyl-coenzyme A thioesterase 8; choloyl-coenzyme A thioesterase; peroxisomal acyl-CoA thioesterase 1; peroxisomal acyl-CoA thioesterase 2; peroxisomal acyl-coenzyme A thioester hydrolase 1; peroxisomal long-chain acyl-CoA thioesterase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170789); (R-MMU-193368); (R-MMU-2046106); (R-MMU-389887); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11673457;16141203;21750661;22645316;30059200;31219806;34428180", "class_list": "", "function": "ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids, [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:11673457). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (PubMed:11673457). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:11673457). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (PubMed:11673457). Is also able to hydrolyze CoA esters of dicarboxylic acids (PubMed:16141203). It is involved in the metabolic regulation of peroxisome proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHM4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0004778 succinyl-CoA hydrolase activity;GO:0033882 choloyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0009062 fatty acid catabolic process;GO:0016559 peroxisome fission;GO:0043649 dicarboxylic acid catabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P58137-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UD01-1", "uniprot_id": [ { "id": "A7L3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UD01", "type": "external" } ], "mass": 10731.0, "length": 97, "protein_name": "Ataxin-7-like protein 3B", "gene_name": "Atxn7l3b", "organism": "Mouse", "refseq_name": "ataxin-7-like protein 3B", "refseq_ac": [ { "id": "NP_001028646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028646", "type": "external" } ], "gene_names_uniprotkb": "Atxn7l3b", "gene_names_refseq": "4921506J03Rik; 6230409E21Rik; Atxn7l3b", "protein_names_uniprotkb": "Ataxin-7-like protein 3B", "protein_names_refseq": "ataxin-7-like protein 3B; putative ataxin-7-like protein 3-like protein; putative ataxin-7-like protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:382423)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16680195;21183079;25428506;34428180;7496147", "class_list": "", "function": "By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 123, "biomarker_type": "", "glycan_count": 26, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q3UD01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V1N9-1", "uniprot_id": [ { "id": "A3LT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V1N9", "type": "external" } ], "mass": 42649.0, "length": 370, "protein_name": "Alpha-1,3-galactosyltransferase 2", "gene_name": "A3galt2", "organism": "Mouse", "refseq_name": "alpha-1,3-galactosyltransferase 2", "refseq_ac": [ { "id": "NP_001009819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009819", "type": "external" } ], "gene_names_uniprotkb": "A3galt2; Igb3s", "gene_names_refseq": "A3galt2; Gm433; iGb3S; iGb3", "protein_names_uniprotkb": "Alpha-1,3-galactosyltransferase 2; 2.4.1.87; Isoglobotriaosylceramide synthase; iGb3 synthase; iGb3S", "protein_names_refseq": "alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase); alpha-1,3-galactosyltransferase 2; iGb3 synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:215493)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15539565;16456004;17372206;18348765;25428506;34418053", "class_list": "glycogene;glycosyltransferase", "function": "A study evaluating aggressive behavior associated with cataract formation in mice with a knockout at this enzyme site is reported., [RefSeq, PubMed]; Invariant natural killer T cells with A3galt2 deficiency had normal development and function., [RefSeq, PubMed]; Molecular cloning and functional analysis of mouse iGb3 synthase in mouse thymus, with its enzyme-synthesized product verified by NMR spectrum., [RefSeq, PubMed]; Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2KGX5;B2KGX6;M9MMK2", "ec_number_list": [ { "id": "2.4.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.87", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity;GO:0001962 alpha-1,3-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0071287 cellular response to manganese ion", "synthesized_glycan_count": 2, "hit_score": 0.9, "record_id": "Q3V1N9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAL7-1", "uniprot_id": [ { "id": "AHDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAL7", "type": "external" } ], "mass": 168081.0, "length": 1594, "protein_name": "Transcription factor Gibbin", "gene_name": "Ahdc1", "organism": "Mouse", "refseq_name": "transcription factor Gibbin isoform 1", "refseq_ac": [ { "id": "NP_666267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666267", "type": "external" } ], "gene_names_uniprotkb": "Ahdc1", "gene_names_refseq": "Ahdc1; D030015G18Rik", "protein_names_uniprotkb": "Transcription factor Gibbin; AT-hook DNA-binding motif-containing protein 1", "protein_names_refseq": "AT-hook DNA-binding motif-containing protein 1; a.T hook DNA-binding motif-containing protein 1; transcription factor Gibbin isoform 1; transcription factor Gibbin", "tax_id": 10090, "disease": "Xia-Gibbs Syndrome (Disease Ontology:DOID:0070055)", "pathway": " (mmu:230793)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.3389/fragi.2021.757801;17525332;21183079;22645316;23806337;31219806;32848054;34428180;34678516;35585237;35822049;36852467;37819197;40885482;40997131", "class_list": "", "function": "Ahdc1 is a potent regulator of obesity and energy metabolism., [RefSeq, PubMed]; Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (By similarity). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q5U5N7;Q8C4Y6;Q8VCU7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0140585 promoter-enhancer loop anchoring activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0005694 chromosome", "go_biological_process": "GO:0006664 glycolipid metabolic process;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q6PAL7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUZ1-1", "uniprot_id": [ { "id": "ABRA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUZ1", "type": "external" } ], "mass": 42831.0, "length": 375, "protein_name": "Actin-binding Rho-activating protein", "gene_name": "Abra", "organism": "Mouse", "refseq_name": "actin-binding Rho-activating protein", "refseq_ac": [ { "id": "NP_780665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780665", "type": "external" } ], "gene_names_uniprotkb": "Abra", "gene_names_refseq": "Abra; C130068O12Rik; STARS", "protein_names_uniprotkb": "Actin-binding Rho-activating protein; STARS; Striated muscle activator of Rho-dependent signaling", "protein_names_refseq": "actin-binding Rho-activating protein; striated muscle activator of Rho-dependent signaling", "tax_id": 10090, "disease": "", "pathway": " (mmu:223513)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11983702;15798203;17194709;17415416;23720020;33963617", "class_list": "", "function": "A novel striated muscle activator of Rho signaling and serum response factor-dependent transcription (striated muscle activator of Rho signaling; STARS), [RefSeq, PubMed]; ABLIM-2 and -3 associate with STARS and directly bind F-actin, [RefSeq, PubMed]; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling., [UniProtKB, PubMed, PubMed]; Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between myocyte enhancer factor-2 and serum response factor., [RefSeq, PubMed]; STARS expression signaling is necessary for skeletal myotube survival but does not influence protein synthesis or degradation., [RefSeq, PubMed]; Striated muscle activator of Rho signalling (STARS) overexpression in the mdx mouse enhances muscle functional capacity and regulates the actin cytoskeleton and oxidative phosphorylation pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB05;Q3UU01;Q8BLH3;Q8K431", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030017 sarcomere;GO:0030016 myofibril", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0045893 positive regulation of DNA-templated transcription;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BUZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0T9-1", "uniprot_id": [ { "id": "ADCYA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0T9", "type": "external" } ], "mass": 186412.0, "length": 1614, "protein_name": "Adenylate cyclase type 10", "gene_name": "Adcy10", "organism": "Mouse", "refseq_name": "adenylate cyclase type 10 isoform 1", "refseq_ac": [ { "id": "NP_766617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766617", "type": "external" } ], "gene_names_uniprotkb": "Adcy10; Sacy; Sac", "gene_names_refseq": "4930431D04Rik; 4931412F17; Adcy10; Sacy; sAC", "protein_names_uniprotkb": "Adenylate cyclase type 10; 4.6.1.1; Germ cell soluble adenylyl cyclase; Testicular soluble adenylyl cyclase; sAC", "protein_names_refseq": "adenylate cyclase type 10 isoform 1; adenylate cyclase type 10; germ cell soluble adenylyl cyclase; testicular soluble adenylyl cyclase", "tax_id": 10090, "disease": "", "pathway": " (mmu:271639); (R-MMU-5610787)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11423534;12475901;14976244;16054031;21750661;25428506", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (PubMed:14976244, PubMed:16054031). Involved in ciliary beat regulation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRJ9;Q3V0F8", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0045819 positive regulation of glycogen catabolic process;GO:2001171 positive regulation of ATP biosynthetic process;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0006171 cAMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C0T9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQR4-1", "uniprot_id": [ { "id": "ACO13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQR4", "type": "external" } ], "mass": 15183.0, "length": 140, "protein_name": "Acyl-coenzyme A thioesterase 13", "gene_name": "Acot13", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 13", "refseq_ac": [ { "id": "NP_080066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080066", "type": "external" } ], "gene_names_uniprotkb": "Acot13; Them2", "gene_names_refseq": "0610006O17Rik; Acot13; Them2", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 13; 3.1.2.-; 3.1.2.2; Acyl-CoA thioesterase 13; Hotdog-fold thioesterase superfamily member 2; Palmitoyl-CoA hydrolase; THEM2; Thioesterase superfamily member 2", "protein_names_refseq": "acyl-coenzyme A thioesterase 13; hotdog-fold thioesterase superfamily member 2; palmitoyl-CoA hydrolase; thioesterase superfamily member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66834); (R-MMU-77289)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17045243;17704541;19405909;22345407;23576753;23901139;24072708;30523156;34428180;34433228;36288343;37453647;37507081;39927985", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:19405909). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (PubMed:19405909). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (PubMed:24072708)., [UniProtKB, UniProtKB, PubMed, PubMed]; PC-TP-THEM2 complex reduces phosphorylation and stability of IRS2 and increases stability of the TSC1-TSC2 complex Publication Status: Online-Only, [RefSeq, PubMed]; T a pathogenic role of Them2 in the biosynthesis of glycerolipid metabolites that promote hepatic insulin resistance, [RefSeq, PubMed]; Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice., [RefSeq, PubMed]; Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2) and the homeodomain transcription factor Pax3 (paired box gene 3), respectively, as PC-TP-interacting proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0051289 protein homotetramerization;GO:0120163 negative regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9CQR4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBL9-1", "uniprot_id": [ { "id": "ABHD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBL9", "type": "external" } ], "mass": 39155.0, "length": 351, "protein_name": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5", "gene_name": "Abhd5", "organism": "Mouse", "refseq_name": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1", "refseq_ac": [ { "id": "NP_080455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080455", "type": "external" } ], "gene_names_uniprotkb": "Abhd5", "gene_names_refseq": "1300003D03Rik; 2010002J10Rik; Abhd5; CGI-58; IECN5; NCIE2", "protein_names_uniprotkb": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 2.3.1.51; Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58; Protein CGI-58", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain-containing protein 5; lipid droplet-binding protein CGI-58", "tax_id": 10090, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); colon adenocarcinoma (Disease Ontology:DOID:234); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:67469)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15136565;15292255;16679289;17308334;18606822;18832586;19064991;19801371;21148142;21750661;25421061;26083785;36515301;37507081;38135254", "class_list": "", "function": "Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise., [RefSeq, PubMed]; CGI-58 binds to perilipin A-coated lipid droplets in a manner that is dependent upon the metabolic status of the adipocyte and the activity of cAMP-dependent protein kinase, [RefSeq, PubMed]; CGI-58 facilitates lipolysis in cooperation with perilipin and other factors, including lipases, [RefSeq, PubMed]; CGI-58 interacts with adipose triglyceride lipase, stimulating its TG hydrolase activity up to 20-fold, [RefSeq, PubMed]; CGI-58 interacts with perilipin and is localized to lipid droplets, [RefSeq, PubMed]; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:19801371). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor (PubMed:19801371). Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (PubMed:19801371). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (PubMed:26083785)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58. Erratum:[J Lipid Res. 2024 Aug;65(8):100613. doi: 10.1016/j.jlr.2024.100613. PMID: 39128381], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTY3", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity;GO:0060229 lipase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9DBL9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCD0-1", "uniprot_id": [ { "id": "6PGD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCD0", "type": "external" } ], "mass": 53247.0, "length": 483, "protein_name": "6-phosphogluconate dehydrogenase, decarboxylating", "gene_name": "Pgd", "organism": "Mouse", "refseq_name": "6-phosphogluconate dehydrogenase, decarboxylating isoform 1", "refseq_ac": [ { "id": "NP_001074743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074743", "type": "external" } ], "gene_names_uniprotkb": "Pgd", "gene_names_refseq": "0610042A05Rik; Pgd", "protein_names_uniprotkb": "6-phosphogluconate dehydrogenase, decarboxylating; 1.1.1.44", "protein_names_refseq": "6-phosphogluconate dehydrogenase, decarboxylating isoform 1; 6-phosphogluconate dehydrogenase, decarboxylating", "tax_id": 10090, "disease": "", "pathway": " (mmu:110208); (R-MMU-71336)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;23806337;31219806;33300544;33691103;34428180;34709178;37453647;37507081;39627609", "class_list": "", "function": "6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function. Publication Status: Online-Only, [RefSeq, PubMed]; Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function., [RefSeq, PubMed]; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD80", "ec_number_list": [ { "id": "1.1.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.44", "type": "external" } ], "go_molecular_function": "GO:0031406 carboxylic acid binding;GO:0030246 carbohydrate binding;GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006098 pentose-phosphate shunt;GO:0009051 pentose-phosphate shunt, oxidative branch;GO:0019322 pentose biosynthetic process;GO:0019521 D-gluconate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DCD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERZ3-1", "uniprot_id": [ { "id": "ACM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERZ3", "type": "external" } ], "mass": 66212.0, "length": 589, "protein_name": "Muscarinic acetylcholine receptor M3", "gene_name": "Chrm3", "organism": "Mouse", "refseq_name": "muscarinic acetylcholine receptor M3", "refseq_ac": [ { "id": "NP_150372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150372", "type": "external" } ], "gene_names_uniprotkb": "Chrm3; Chrm-3", "gene_names_refseq": "Chrm-3; Chrm3; M3R; M3", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M3; Mm3 mAChR", "protein_names_refseq": "AChR M3; mm3 mAChR; muscarinic acetylcholine receptor 3; muscarinic acetylcholine receptor M3", "tax_id": 10090, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); prune belly syndrome (Disease Ontology:DOID:0060889); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bladder disease (Disease Ontology:DOID:365); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:12671); (R-MMU-390648); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "19575010;21056967;21183079;31490711;39172154;7874308", "class_list": "", "function": "Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q64055", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:0042166 acetylcholine binding;GO:0031789 G protein-coupled acetylcholine receptor binding;GO:0050997 quaternary ammonium group binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ERZ3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXM0-1", "uniprot_id": [ { "id": "ABHD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXM0", "type": "external" } ], "mass": 48378.0, "length": 425, "protein_name": "Monoacylglycerol lipase ABHD2", "gene_name": "Abhd2", "organism": "Mouse", "refseq_name": "monoacylglycerol lipase ABHD2", "refseq_ac": [ { "id": "NP_061281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061281", "type": "external" } ], "gene_names_uniprotkb": "Abhd2; Labh-2; Labh2", "gene_names_refseq": "2210009N18Rik; Abhd2; LABH2; Labh-2", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD2; 2-arachidonoylglycerol hydrolase; 3.1.1.23; 3.1.1.6; 3.1.1.79; Abhydrolase domain-containing protein 2; Acetylesterase; Lung alpha/beta hydrolase 2; MmLABH2; Triacylglycerol lipase", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 2; acetylesterase; alpha/beta hydrolase fold protein; lung alpha/beta hydrolase 2; mmLABH2; monoacylglycerol lipase ABHD2; triacylglycerol lipase", "tax_id": 10090, "disease": "", "pathway": " (mmu:54608)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11922611;15721306;19250629;20173027;25428506;26989199;34203471;34428180;37523383;38088307;38197032", "class_list": "", "function": "ABHD2 deficiency aggravates ovalbumin-induced airway remodeling through the PI3K/Akt pathway in an animal model of chronic asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta. Publication Status: Online-Only, [RefSeq, PubMed]; LABH-2 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the testis, [RefSeq, PubMed]; Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin. Publication Status: Online-Only, [RefSeq, PubMed]; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration (PubMed:15721306)., [UniProtKB, PubMed, PubMed, UniProtKB]; These findings suggest that derangement in alveolar phospholipid metabolism can induce emphysema, and that Abhd2 plays a critical role in maintaining lung structural integrity., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5E8;Q5FWC6;Q9D7Y8", "ec_number_list": [ { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding;GO:0004806 triacylglycerol lipase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0046464 acylglycerol catabolic process;GO:0007340 acrosome reaction;GO:0009611 response to wounding;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QXM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY84-1", "uniprot_id": [ { "id": "ACL7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY84", "type": "external" } ], "mass": 49451.0, "length": 440, "protein_name": "Actin-like protein 7A", "gene_name": "Actl7a", "organism": "Mouse", "refseq_name": "actin-like protein 7A", "refseq_ac": [ { "id": "NP_033741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033741", "type": "external" } ], "gene_names_uniprotkb": "Actl7a; Tact2", "gene_names_refseq": "Actl7a; Tact2", "protein_names_uniprotkb": "Actin-like protein 7A; Actin-like-7-alpha; T-actin-2; Testis-specific actin-2", "protein_names_refseq": "T-actin-2; actin-like Tact2; actin-like protein 7A; actin-like-7-alpha; t-actin 2; testis-specific actin-2", "tax_id": 10090, "disease": "spermatogenic failure 86 (Disease Ontology:DOID:0070585); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); male infertility (Disease Ontology:DOID:12336); nemaline myopathy (Disease Ontology:DOID:3191); bladder urothelial carcinoma (Disease Ontology:DOID:4006); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:11470)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10373328;12672658;12704725;21278383;25428506;27802388;32923619;34418053;35921706;36734600;37667331", "class_list": "", "function": "Essential for normal spermatogenesis and male fertility (PubMed:35921706, PubMed:36734600, PubMed:37667331). Required for normal sperm head morphology, acroplaxome formation, acrosome attachment, and acrosome granule stability (PubMed:36734600, PubMed:37667331). May anchor and stabilize acrosomal adherence to the acroplaxome at least in part by facilitating the presence of F-actin in the subacrosomal space (PubMed:36734600). May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis (PubMed:32923619)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that T-ACTINs play important roles in sperm function and in the specific morphogenesis of spermatozoa during spermiogenesis, [RefSeq, PubMed]; Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AMK4;Q9D9P4;Q9JMI5", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QY84-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWN8-1", "uniprot_id": [ { "id": "ACOT4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWN8", "type": "external" } ], "mass": 46481.0, "length": 421, "protein_name": "Peroxisomal succinyl-coenzyme A thioesterase", "gene_name": "Acot4", "organism": "Mouse", "refseq_name": "peroxisomal succinyl-coenzyme A thioesterase", "refseq_ac": [ { "id": "NP_599008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599008", "type": "external" } ], "gene_names_uniprotkb": "Acot4; Pte1b; Pte2b", "gene_names_refseq": "Acot4; B430212I04Rik; PTE-Ib; Pte1b; Pte2b", "protein_names_uniprotkb": "Peroxisomal succinyl-coenzyme A thioesterase; 3.1.2.3; Acyl-CoA thioesterase 4; Acyl-coenzyme A thioesterase 4; PTE-2b; PTE-Ib; Peroxisomal acyl coenzyme A thioester hydrolase Ib; Peroxisomal long-chain acyl-CoA thioesterase Ib", "protein_names_refseq": "PTE-2b; acyl-coenzyme A thioesterase 4; peroxisomal acyl coenzyme A thioester hydrolase Ib; peroxisomal acyl-CoA thioesterase 2B; peroxisomal long-chain acyl-CoA thioesterase Ib; peroxisomal succinyl-coenzyme A thioesterase", "tax_id": 10090, "disease": "", "pathway": " (mmu:171282); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10567408;16141203;16940157;21750661;23806337;37453647", "class_list": "", "function": "ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids, [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16141203, PubMed:16940157). In contrast to its human ortholog, functions essentially as a succinyl-CoA thioesterase with no activity with medium to long chain saturated acyl-CoAs and with a low activity toward glutaryl-CoA (PubMed:16141203, PubMed:16940157)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJQ1;Q8BL20;Q9QYR8", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004778 succinyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006104 succinyl-CoA metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BWN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI91-1", "uniprot_id": [ { "id": "ACTN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI91", "type": "external" } ], "mass": 103834.0, "length": 894, "protein_name": "Alpha-actinin-2", "gene_name": "Actn2", "organism": "Mouse", "refseq_name": "alpha-actinin-2", "refseq_ac": [ { "id": "NP_150371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150371", "type": "external" } ], "gene_names_uniprotkb": "Actn2", "gene_names_refseq": "1110008F24Rik; Actn2", "protein_names_uniprotkb": "Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin skeletal muscle; alpha-actinin-2", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); congenital myopathy 8 (Disease Ontology:DOID:0081342); dilated cardiomyopathy 1AA (Disease Ontology:DOID:0110428); focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128)", "pathway": " (mmu:11472); (R-MMU-114608); (R-MMU-390522); (R-MMU-438066); (R-MMU-5673001)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10788519;11440986;19932097;21183079;21750661;34428180;36288343;37507081;39927985", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3UW84", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030054 cell junction", "go_biological_process": "GO:0006936 muscle contraction;GO:0042391 regulation of membrane potential;GO:0072659 protein localization to plasma membrane;GO:0043268 positive regulation of potassium ion transport;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JI91-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UNX5-1", "uniprot_id": [ { "id": "ACSM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UNX5", "type": "external" } ], "mass": 65623.0, "length": 580, "protein_name": "Acyl-coenzyme A synthetase ACSM3, mitochondrial", "gene_name": "Acsm3", "organism": "Mouse", "refseq_name": "acyl-coenzyme A synthetase ACSM3, mitochondrial", "refseq_ac": [ { "id": "NP_058566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058566", "type": "external" } ], "gene_names_uniprotkb": "Acsm3; Sah; Sa", "gene_names_refseq": "Acsm3; Sah; Sa", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM3, mitochondrial; 6.2.1.17; 6.2.1.2; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Propionate--CoA ligase; Protein SA homolog", "protein_names_refseq": "SA hypertension-associated homolog; acyl-coenzyme A synthetase ACSM3, mitochondrial; butyrate--CoA ligase 3; butyryl-coenzyme A synthetase 3; middle-chain acyl-CoA synthetase 3; propionate--CoA ligase; protein SA homolog", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); ulcerative colitis (Disease Ontology:DOID:8577); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (mmu:20216)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11470804;12707288;15525578;23576753;23806337;25744306;34428180;35820727;38191811;9449642;9507200", "class_list": "", "function": "Analysis of the role of the SA gene in blood pressure regulation., [RefSeq, PubMed]; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11470804). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (PubMed:11470804)., [UniProtKB, PubMed]; Data suggest that expression of Acsm3 in adipose tissue can be regulated by dietary factors; here, expression of Acsm3 in white adipose tissue is down-regulated in obesity caused by high-fat diet., [RefSeq, PubMed]; Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4alpha-p38 MAPK axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRY2;Q91WI1;Q9Z2F3;Q9Z2X0", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity;GO:0018729 propionate CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3UNX5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBK0-1", "uniprot_id": [ { "id": "ACO12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBK0", "type": "external" } ], "mass": 61762.0, "length": 556, "protein_name": "Acetyl-coenzyme A thioesterase", "gene_name": "Acot12", "organism": "Mouse", "refseq_name": "acetyl-coenzyme A thioesterase isoform 1", "refseq_ac": [ { "id": "NP_083066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083066", "type": "external" } ], "gene_names_uniprotkb": "Acot12; Cach1; Cach", "gene_names_refseq": "1300004O04Rik; 4930449F15Rik; Acot12; CACH-1; Cach; mCACH-1", "protein_names_uniprotkb": "Acetyl-coenzyme A thioesterase; 3.1.2.1; Acyl-CoA thioester hydrolase 12; Acyl-CoA thioesterase 12; Acyl-coenzyme A thioesterase 12; CACH-1; Cytoplasmic acetyl-CoA hydrolase 1; mCACH-1", "protein_names_refseq": "acetyl-coenzyme A thioesterase isoform 1; acetyl-coenzyme A thioesterase; acyl-CoA thioester hydrolase 12; acyl-coenzyme A thioesterase 12; cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase", "tax_id": 10090, "disease": "liver cancer (Disease Ontology:DOID:3571)", "pathway": " (mmu:74156); (R-MMU-77289)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12545200;23806337;30084848;31219806;34285335;34428180;37150501;37908734", "class_list": "", "function": "Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis., [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA., [UniProtKB, UniProtKB]; Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue., [RefSeq, PubMed]; Possibly involved in fat metabolism. Here it is sequenced and expressed functionally., [RefSeq, PubMed]; Upregulated FOXM1 stimulates chondrocyte senescence in Acot12[-/-]Nudt7[-/-] double knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544M5;Q8R108", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" } ], "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0052689 carboxylic ester hydrolase activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006084 acetyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DBK0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYR9-1", "uniprot_id": [ { "id": "ACOT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYR9", "type": "external" } ], "mass": 49657.0, "length": 453, "protein_name": "Acyl-coenzyme A thioesterase 2, mitochondrial", "gene_name": "Acot2", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_598949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598949", "type": "external" } ], "gene_names_uniprotkb": "Acot2; Mte1", "gene_names_refseq": "Acot2; MTE-I; Mte1", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 2, mitochondrial; 3.1.2.2; Acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterase 2; MTE-I; Very-long-chain acyl-CoA thioesterase", "protein_names_refseq": "acyl coenzyme A thioester hydrolase; acyl-coenzyme A thioesterase 2, mitochondrial precursor; acyl-coenzyme A thioesterase 2, mitochondrial; mitochondrial acyl-CoA thioesterase 1; very-long-chain acyl-CoA thioesterase", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:171210); (R-MMU-77289); (R-MMU-9033241); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10567408;11330065;23576753;23806337;25114170;31676684;31930115;36288343;37507081", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:25114170). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:25114170). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (PubMed:25114170)., [UniProtKB, PubMed]; MiR-27b-3p induces acyl-CoA thioesterase 2 (ACOT2) expression in 3T3-L1 cells. Publication Status: Online-Only, [RefSeq, PubMed]; The CoA-insensitive Acot2 could provide a constitutive siphon for long-chain fatty acyl-CoAs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9C9", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QYR9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPS6-1", "uniprot_id": [ { "id": "AKIB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPS6", "type": "external" } ], "mass": 121876.0, "length": 1085, "protein_name": "Ankyrin repeat and IBR domain-containing protein 1", "gene_name": "Ankib1", "organism": "Mouse", "refseq_name": "ankyrin repeat and IBR domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001003909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003909", "type": "external" } ], "gene_names_uniprotkb": "Ankib1; Kiaa1386", "gene_names_refseq": "2310061P20Rik; 4631416I11Rik; Ankib1; mKIAA1386", "protein_names_uniprotkb": "Ankyrin repeat and IBR domain-containing protein 1; 2.3.2.31", "protein_names_refseq": "ankyrin repeat and IBR domain-containing protein 1 isoform 2; ankyrin repeat and IBR domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70797)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;25428506;30016717", "class_list": "", "function": "Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXE1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6ZPS6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQF7-1", "uniprot_id": [ { "id": "AMPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQF7", "type": "external" } ], "mass": 75013.0, "length": 686, "protein_name": "Amphiphysin", "gene_name": "Amph", "organism": "Mouse", "refseq_name": "amphiphysin isoform 2", "refseq_ac": [ { "id": "NP_001276475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276475", "type": "external" } ], "gene_names_uniprotkb": "Amph; Amph1", "gene_names_refseq": "Amph", "protein_names_uniprotkb": "Amphiphysin", "protein_names_refseq": "amphiphysin isoform 2", "tax_id": 10090, "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220)", "pathway": " (mmu:218038); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15345747;21183079;21750661;23651931;34018922;40885482", "class_list": "", "function": "Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1C4", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0044877 protein-containing complex binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007612 learning;GO:0043547 positive regulation of GTPase activity;GO:0045807 positive regulation of endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TQF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0T6-1", "uniprot_id": [ { "id": "AGRG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0T6", "type": "external" } ], "mass": 60072.0, "length": 542, "protein_name": "Adhesion G protein-coupled receptor G3", "gene_name": "Adgrg3", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor G3 precursor", "refseq_ac": [ { "id": "NP_766624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766624", "type": "external" } ], "gene_names_uniprotkb": "Adgrg3; Gpr97", "gene_names_refseq": "A030001G24Rik; Adgrg3; Gpr97; Pb1; Pb99", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G3; G protein-coupled receptor 97", "protein_names_refseq": "G 97; adhesion G protein-coupled receptor G3 precursor; pre B-cell transcription factor 1; probable G-protein coupled receptor 97", "tax_id": 10090, "disease": "", "pathway": " (mmu:54672); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16281060;21750661;23436159;24113187;24178298;27089991;29531097;29860267;30084848;33560396;38345813", "class_list": "", "function": "A possible role of GPR97 in lymphatic remodeling, [RefSeq, PubMed]; Adhesion G protein-coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity (By similarity). May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo (By similarity). Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity (PubMed:24113187, PubMed:27089991, PubMed:38345813). Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes (By similarity). Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Data demonstrate that the pre-B-cell receptor is essential for monoallelic silencing of VpreB and lambda5 at the large pre-BII-cell stage., [RefSeq, PubMed]; Gpr97 deficiency results in an extensive reduction in B220(+) lymphocytes in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that G protein-coupled receptor 97 protein (Gpr97) plays an important role in the development of experimental autoimmune encephalomyelitis (EAE) and may have a therapeutic potential for the treatment of central nervous system (CNS) autoimmunity., [RefSeq, PubMed]; The GPR92 is expressed in the majority of T1R1-positive taste cells., [RefSeq, PubMed]; Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2Q3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0030183 B cell differentiation;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R0T6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70200-1", "uniprot_id": [ { "id": "AIF1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70200", "type": "external" } ], "mass": 16911.0, "length": 147, "protein_name": "Allograft inflammatory factor 1", "gene_name": "Aif1", "organism": "Mouse", "refseq_name": "allograft inflammatory factor 1 isoform a", "refseq_ac": [ { "id": "NP_062340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062340", "type": "external" } ], "gene_names_uniprotkb": "Aif1; Iba1", "gene_names_refseq": "AIF-1; Aif1; D17H6S50E; G1; Iba1", "protein_names_uniprotkb": "Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1", "protein_names_refseq": "allograft inflammatory factor 1 isoform a; ionized calcium binding adapter molecule 1; testis specific", "tax_id": 10090, "disease": "meningoencephalitis (Disease Ontology:DOID:10554); Alzheimer's disease (Disease Ontology:DOID:10652); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cerebral palsy (Disease Ontology:DOID:1969); motor neuron disease (Disease Ontology:DOID:231); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); brain infarction (Disease Ontology:DOID:3454); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:11629)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10934045;11500035;11722645;11916959;14656967;14756805;17011575;21750661", "class_list": "", "function": "Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0071677 positive regulation of mononuclear cell migration;GO:0001774 microglial cell activation;GO:0001934 positive regulation of protein phosphorylation;GO:0006911 phagocytosis, engulfment", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70200-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09174-1", "uniprot_id": [ { "id": "AMACR_MOUSE", "url": "https://www.uniprot.org/uniprot/O09174", "type": "external" } ], "mass": 41704.0, "length": 381, "protein_name": "Alpha-methylacyl-CoA racemase", "gene_name": "Amacr", "organism": "Mouse", "refseq_name": "alpha-methylacyl-CoA racemase", "refseq_ac": [ { "id": "NP_032563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032563", "type": "external" } ], "gene_names_uniprotkb": "Amacr; Macr1", "gene_names_refseq": "Amacr; Macr1", "protein_names_uniprotkb": "Alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; 5.1.99.4", "protein_names_refseq": "2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase; alpha-methylacyl-Coenzyme A racemase", "tax_id": 10090, "disease": "alpha-methylacyl-CoA racemase deficiency (Disease Ontology:DOID:0060602); congenital bile acid synthesis defect 4 (Disease Ontology:DOID:0111068); urinary bladder cancer (Disease Ontology:DOID:11054); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:17117); (R-MMU-193368); (R-MMU-193775); (R-MMU-389887); (R-MMU-9033241)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10770938;23576753;23680781;23806337;24735479;25428506;26248199;26648339;31599954;34428180;37453647;37507081;9307041", "class_list": "", "function": "AMACR has a role in the synthesis of bile acids., [RefSeq, PubMed]; Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (By similarity). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (By similarity)., [UniProtKB, UniProtKB]; Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids., [RefSeq, PubMed]; Observed a disease-dependent elevation of AMACR expression in monocytes and T cells from blood, draining lymph nodes and spleen of autoimmune experimental encephalomyelitis mice during preclinical phase; in vitro analysis revealed proliferation of T cells was inhibited in AMACR KO mice, but T-cell polarization was switched toward a pathogenic state, [RefSeq, PubMed]; Phytol causes primary failure in liver leading to death of Amacr-/- mice thus emphasizing the indispensable role of Amacr in detoxification of alpha-methyl-branched fatty acids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543Q9;Q9DCW6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008111 alpha-methylacyl-CoA racemase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006699 bile acid biosynthetic process;GO:0008206 bile acid metabolic process;GO:0008300 isoprenoid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O09174-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61549-1", "uniprot_id": [ { "id": "AGRE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61549", "type": "external" } ], "mass": 102130.0, "length": 931, "protein_name": "Adhesion G protein-coupled receptor E1", "gene_name": "Adgre1", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor E1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034260", "type": "external" } ], "gene_names_uniprotkb": "Adgre1; Emr1; Gpf480", "gene_names_refseq": "Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor", "protein_names_refseq": "EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; adhesion G protein-coupled receptor E1 isoform 1 precursor; cell surface glycoprotein F4/80", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:13733); (R-MMU-373080)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15883173;21750661;34428180;8550607;9169125", "class_list": "", "function": "Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61549-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPR4-1", "uniprot_id": [ { "id": "ACTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPR4", "type": "external" } ], "mass": 103068.0, "length": 892, "protein_name": "Alpha-actinin-1", "gene_name": "Actn1", "organism": "Mouse", "refseq_name": "alpha-actinin-1 isoform 1", "refseq_ac": [ { "id": "NP_598917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598917", "type": "external" } ], "gene_names_uniprotkb": "Actn1", "gene_names_refseq": "3110023F10Rik; Actn1a; Actn1", "protein_names_uniprotkb": "Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1", "protein_names_refseq": "F-actin cross-linking protein; alpha actinin 1a; alpha-actinin-1 isoform 1; alpha-actinin-1; non-muscle alpha-actinin-1", "tax_id": 10090, "disease": "platelet-type bleeding disorder 15 (Disease Ontology:DOID:0111053); focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128)", "pathway": " (mmu:109711); (R-MMU-114608); (R-MMU-446388); (R-MMU-9013418); (R-MMU-9035034)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "11114196;17298598;18250455;21540332;23100251;23434115;26495903;26740625;27301331;28011936;28528544;28935714;31219806;33300544;35984892;37453647", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament", "go_biological_process": "GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0048041 focal adhesion assembly;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7TPR4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGA8-1", "uniprot_id": [ { "id": "ACSM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGA8", "type": "external" } ], "mass": 64328.0, "length": 578, "protein_name": "Acyl-coenzyme A synthetase ACSM5, mitochondrial", "gene_name": "Acsm5", "organism": "Mouse", "refseq_name": "acyl-coenzyme A synthetase ACSM5, mitochondrial precursor", "refseq_ac": [ { "id": "NP_848873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848873", "type": "external" } ], "gene_names_uniprotkb": "Acsm5; Macs3", "gene_names_refseq": "Acsm5; C730019D22; C730027J19Rik", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM5, mitochondrial; 6.2.1.2", "protein_names_refseq": "acyl-coenzyme A synthetase ACSM5, mitochondrial precursor; acyl-coenzyme A synthetase ACSM5, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:272428); (R-MMU-177128); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;23576753;23806337;34428180;37957699", "class_list": "", "function": "ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Acyl-CoA synthetase that catalyzes the ATP-dependent activation of fatty acids to their corresponding acyl-CoA thioesters, the first committed step in fatty acid metabolism (By similarity). Negatively regulates lipid accumulation via inhibition of FABP4-PPARgamma signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJS0;Q8BM02;Q8BWQ8;Q8BWS7", "ec_number_list": [ { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R010-1", "uniprot_id": [ { "id": "AIMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R010", "type": "external" } ], "mass": 35378.0, "length": 320, "protein_name": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2", "gene_name": "Aimp2", "organism": "Mouse", "refseq_name": "aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001165617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165617", "type": "external" } ], "gene_names_uniprotkb": "Aimp2; Jtv1", "gene_names_refseq": "Aimp2(p38); Aimp2; Jtv1", "protein_names_uniprotkb": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1", "protein_names_refseq": "ARS interacting multifunctional protein 2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1; aminoacyl tRNA synthase complex-interacting multifunctional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; protein JTV-1", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 17 (Disease Ontology:DOID:0070404)", "pathway": " (mmu:231872); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12060739;12819782;16135753;17242355;18695251;21183079;25428506;27302160;30084848;34428180;34817071;36242734;39927985", "class_list": "", "function": "Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death., [RefSeq, PubMed]; Comparative proteomic profiling reveals a pathogenic role for the O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic steatosis in mice., [RefSeq, PubMed]; Our findings show how DX2 promotes lung cancer progression and how its activity may be thwarted as a strategy to treat patients with lung cancers exhibiting elevated DX2 levels, [RefSeq, PubMed]; Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:12060739). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation (PubMed:12819782). Blocks MDM2-mediated ubiquitination and degradation of p53/TP53 (PubMed:18695251). Functions as a proapoptotic factor (PubMed:16135753)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP67;Q8R2Y6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:0006412 translation;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R010-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Z0-1", "uniprot_id": [ { "id": "ADIPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Z0", "type": "external" } ], "mass": 33267.0, "length": 308, "protein_name": "Adipolin", "gene_name": "C1qtnf12", "organism": "Mouse", "refseq_name": "adipolin precursor", "refseq_ac": [ { "id": "NP_080401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080401", "type": "external" } ], "gene_names_uniprotkb": "C1qtnf12; C1qdc2; Ctrp12; Fam132a", "gene_names_refseq": "1110035L05Rik; C1qdc2; C1qtnf12; CTRP12; Fam132a; alipolin", "protein_names_uniprotkb": "Adipolin; Adipolin cleaved form; Adipolin fCTRP12; Adipolin full-length form; Adipolin gCTRP12; Adipose-derived insulin-sensitizing factor; Complement C1q tumor necrosis factor-related protein 12", "protein_names_refseq": "C1q domain containing 2; adipolin precursor; adipolin; adipose-derived insulin-sensitizing factor; complement C1q tumor necrosis factor-related protein 12; family with sequence similarity 132, member A; protein FAM132A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67389)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21849507;22275362;22351773;22736092;22942287;23068097;23633521;24358263;39627609", "class_list": "", "function": "Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes (PubMed:22942287)., [UniProtKB, PubMed]; Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes (PubMed:22942287)., [UniProtKB, PubMed]; Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism, [RefSeq, PubMed]; CTRP12 as a novel metabolic regulator linking adipose tissue to whole body glucose homeostasis through insulin-dependent and independent mechanisms., [RefSeq, PubMed]; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (PubMed:21849507, PubMed:22275362)., [UniProtKB, PubMed, PubMed]; The aim of this study was to demonstrate adipolin expression in human and murine chondrocytes and to elucidate the intracellular mechanism involved in adipolin basal expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQI8", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010906 regulation of glucose metabolic process;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0046324 regulation of D-glucose import;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R2Z0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPY7-1", "uniprot_id": [ { "id": "AMPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPY7", "type": "external" } ], "mass": 56141.0, "length": 519, "protein_name": "Cytosol aminopeptidase", "gene_name": "Lap3", "organism": "Mouse", "refseq_name": "cytosol aminopeptidase", "refseq_ac": [ { "id": "NP_077754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077754", "type": "external" } ], "gene_names_uniprotkb": "Lap3; Lapep", "gene_names_refseq": "2410015L10Rik; LAP-3; Lap3; Lapep; Lap; Pep-7; Pep-S; Pep7; Peps", "protein_names_uniprotkb": "Cytosol aminopeptidase; 3.4.11.1; 3.4.11.5; 3.4.13.23; Cysteinylglycine-S-conjugate dipeptidase; LAP-3; Leucine aminopeptidase 3; Leucyl aminopeptidase; Peptidase S; Proline aminopeptidase; Prolyl aminopeptidase", "protein_names_refseq": "cysteinylglycine-S-conjugate dipeptidase; cytosol aminopeptidase; leucyl aminopeptidase; peptidase 7; peptidase S; proline aminopeptidase; prolyl aminopeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66988)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17242355;21183079;21750661;23576753;23806337;26495903;26740625;30084848;33725478;34428180;37435895;37453647;37507081", "class_list": "", "function": "Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status., [UniProtKB, UniProtKB]; The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT-TFE3 pathway in C2C12 myoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFS5;Q4FJV1;Q4FK15;Q99P44;Q9CWN8", "ec_number_list": [ { "id": "3.4.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.1", "type": "external" }, { "id": "3.4.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.5", "type": "external" }, { "id": "3.4.13.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.23", "type": "external" }, { "id": "3.4.13.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.18", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004180 carboxypeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CPY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBT5-2", "uniprot_id": [ { "id": "AMPD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBT5", "type": "external" } ], "mass": 94696.0, "length": 824, "protein_name": "AMP deaminase 2", "gene_name": "Ampd2", "organism": "Mouse", "refseq_name": "AMP deaminase 2 isoform b", "refseq_ac": [ { "id": "NP_001276648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276648", "type": "external" } ], "gene_names_uniprotkb": "Ampd2", "gene_names_refseq": "1200014F01Rik; Ampd-2; Ampd2; m4521Dajl", "protein_names_uniprotkb": "AMP deaminase 2; 3.5.4.6; AMP deaminase isoform L", "protein_names_refseq": "AMP deaminase 2 isoform b; AMP deaminase 2; adenosine monophosphate deaminase 2 (isoform L)", "tax_id": 10090, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 9 (Disease Ontology:DOID:0060278); hereditary spastic paraplegia 63 (Disease Ontology:DOID:0110814)", "pathway": " (mmu:109674); (R-MMU-74217)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17242355;17947660;19131326;21183079;21952136;23911318;24129315;25428506;26495903;30084848;37567359;38992061", "class_list": "", "function": "AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle., [UniProtKB, PubMed]; AMPD2 plays important roles in regulating hepatic glucose and lipid metabolism., [RefSeq, PubMed]; Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AE27;A2AE28;Q91YI2", "ec_number_list": [ { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0009117 nucleotide metabolic process;GO:0097009 energy homeostasis;GO:0042632 cholesterol homeostasis;GO:0006188 IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DBT5-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLJ2-1", "uniprot_id": [ { "id": "AL9A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLJ2", "type": "external" } ], "mass": 53515.0, "length": 494, "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase", "gene_name": "Aldh9a1", "organism": "Mouse", "refseq_name": "4-trimethylaminobutyraldehyde dehydrogenase isoform 1", "refseq_ac": [ { "id": "NP_064377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064377", "type": "external" } ], "gene_names_uniprotkb": "Aldh9a1", "gene_names_refseq": "Abaldh; Aldh9a1; ESTM40; TMABA-DH; Tmabadh", "protein_names_uniprotkb": "4-trimethylaminobutyraldehyde dehydrogenase; 1.2.1.19; 1.2.1.3; 1.2.1.46; 1.2.1.47; Aldehyde dehydrogenase family 9 member A1; Formaldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; TMABA-DH; TMABADH", "protein_names_refseq": "4-trimethylaminobutyraldehyde dehydrogenase isoform 1; 4-trimethylaminobutyraldehyde dehydrogenase; aldehyde dehydrogenase family 9 member A1; formaldehyde dehydrogenase; gamma-aminobutyraldehyde dehydrogenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56752); (R-MMU-71262)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10702312;23576753;23806337;25428506;26495903;26740625;30084848;34428180;37453647;40684658", "class_list": "", "function": "Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U367", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0042802 identical protein binding;GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0051287 NAD binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0045329 carnitine biosynthetic process;GO:0009437 carnitine metabolic process;GO:0042429 serotonin catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZQ1-3", "uniprot_id": [ { "id": "AFAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZQ1", "type": "external" } ], "mass": 206499.0, "length": 1820, "protein_name": "Afadin", "gene_name": "Afdn", "organism": "Mouse", "refseq_name": "afadin", "refseq_ac": [ { "id": "NP_034936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034936", "type": "external" } ], "gene_names_uniprotkb": "Afdn; Af6; Mllt4", "gene_names_refseq": "5033403D15Rik; AF6; Af-6; Afadin; Afdn; Gm314; I-afadin; Mllt4; S-afadin", "protein_names_uniprotkb": "Afadin; Afadin adherens junction formation factor; Protein Af-6", "protein_names_refseq": "afadin; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia; protein Af-6; translocated to, 4", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:17356); (R-MMU-418990)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10477764;10744716;16452087;17242355;19131326;19144319;21183079;23806337;25428506;30084848;30463011;31219806;33963248;34203471;34428180;35820727;36210013;37276970;37828052", "class_list": "", "function": "Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm (PubMed:10477764). Essential for the organization of adherens junctions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Rap1 regulates lumen continuity via Afadin in renal epithelia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0050839 cell adhesion molecule binding;GO:0031267 small GTPase binding;GO:0030274 LIM domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:1903861 positive regulation of dendrite extension;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9QZQ1-3", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ5-1", "uniprot_id": [ { "id": "AKA12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTQ5", "type": "external" } ], "mass": 180695.0, "length": 1684, "protein_name": "A-kinase anchor protein 12", "gene_name": "Akap12", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 12", "refseq_ac": [ { "id": "NP_112462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112462", "type": "external" } ], "gene_names_uniprotkb": "Akap12; Gag12; Ssecks", "gene_names_refseq": "Akap12; SSeCKS; Srcs5; Tsga12", "protein_names_uniprotkb": "A-kinase anchor protein 12; AKAP-12; Germ cell lineage protein gercelin; SSeCKS; Src-suppressed C kinase substrate", "protein_names_refseq": "A kinase (PRKA) anchor protein (gravin) 12; A-kinase anchor protein 12; AKAP-12; gercelin; germ cell lineage protein gercelin; src-suppressed C kinase substrate; testis specific gene A12; v-src suppressed transcript 5", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); colorectal carcinoma (Disease Ontology:DOID:0080199); sciatic neuropathy (Disease Ontology:DOID:11446); brain ischemia (Disease Ontology:DOID:2316); osteosarcoma (Disease Ontology:DOID:3347); liver cirrhosis (Disease Ontology:DOID:5082); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:83397); (R-MMU-9035034)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "11429284;11799143;15345747;16452087;17622165;19131326;21183079;21750661;25428506;26495903;28528544;30084848;30779550;31219806;34428180;36464273;36852467;37507081;38506047;40021952;40885482", "class_list": "", "function": "AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction., [RefSeq, PubMed]; Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)., [UniProtKB]; Loss of AKAP12 aggravates rheumatoid arthritis-like symptoms and cardiac damage in collagen-induced arthritis mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80SS4;Q810D4;Q8BPK4;Q99MP1", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008179 adenylate cyclase binding;GO:0051018 protein kinase A binding;GO:0030159 signaling receptor complex adaptor activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035733 hepatic stellate cell activation;GO:0007165 signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9WTQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN4-1", "uniprot_id": [ { "id": "C1QL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESN4", "type": "external" } ], "mass": 26687.0, "length": 255, "protein_name": "Complement C1q-like protein 3", "gene_name": "C1ql3", "organism": "Mouse", "refseq_name": "complement C1q-like protein 3 precursor", "refseq_ac": [ { "id": "NP_694795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694795", "type": "external" } ], "gene_names_uniprotkb": "C1ql3; C1ql; Ctrp13", "gene_names_refseq": "1110065A22Rik; Adij; C1ql3; C1ql; C1qtnf13; CTRP13; K100", "protein_names_uniprotkb": "Complement C1q-like protein 3; C1q and tumor necrosis factor-related protein 13; C1q/TNF-related protein 13; CTRP13; Gliacolin", "protein_names_refseq": "C1q and tumor necrosis factor-related protein 13; C1q/TNF-related protein 13; adiponectin j; complement C1q-like protein 3 precursor; complement C1q-like protein 3; gliacolin", "tax_id": 10090, "disease": "", "pathway": " (mmu:227580)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10862616;21262840;21378161;23449976;37844630", "class_list": "", "function": "CTRP13 ablation improves systemic glucose and lipid metabolism., [RefSeq, PubMed]; CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase., [RefSeq, PubMed]; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUR9;B0LXL6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099558 maintenance of synapse structure;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0050807 regulation of synapse organization;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESN4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WT5-1", "uniprot_id": [ { "id": "AFTIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WT5", "type": "external" } ], "mass": 101131.0, "length": 931, "protein_name": "Aftiphilin", "gene_name": "Aftph", "organism": "Mouse", "refseq_name": "aftiphilin isoform 2", "refseq_ac": [ { "id": "NP_001239432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239432", "type": "external" } ], "gene_names_uniprotkb": "Aftph; Afth", "gene_names_refseq": "Aftph", "protein_names_uniprotkb": "Aftiphilin", "protein_names_refseq": "aftiphilin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216549)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;19144319;21183079;21750661;25153642;34428180", "class_list": "", "function": "Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SSE6;Q99KJ1", "ec_number_list": [], "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80WT5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UEG6-1", "uniprot_id": [ { "id": "AGT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UEG6", "type": "external" } ], "mass": 57115.0, "length": 513, "protein_name": "Alanine--glyoxylate aminotransferase 2, mitochondrial", "gene_name": "Agxt2", "organism": "Mouse", "refseq_name": "alanine--glyoxylate aminotransferase 2, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001297664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297664", "type": "external" } ], "gene_names_uniprotkb": "Agxt2", "gene_names_refseq": "Agxt2", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase 2, mitochondrial; (R)-3-amino-2-methylpropionate--pyruvate transaminase; 2.6.1.18; 2.6.1.40; 2.6.1.44; AGT 2; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase", "protein_names_refseq": "(R)-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase; alanine--glyoxylate aminotransferase 2, mitochondrial isoform 1; alanine--glyoxylate aminotransferase 2, mitochondrial; beta-ALAAT II; beta-alanine-pyruvate aminotransferase", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); mild cognitive impairment (Disease Ontology:DOID:0080832); hypertension (Disease Ontology:DOID:10763); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); intermittent claudication (Disease Ontology:DOID:3669); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:268782); (R-MMU-389661)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23023372;23154179;23280748;23576753;23806337;27062388;27752063;27752141;34428180;35672381;35990633;37453647", "class_list": "", "function": "Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure., [RefSeq, PubMed]; DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers. Publication Status: Online-Only, [RefSeq, PubMed]; In this work, we describe an assay for the AGXT2 activity in mouse liver and kidney tissue. The overall production rates of DMGV-d(6) in mice were 195.37 pmol/min/mg total protein in liver and 85.21 pmol/min/mg total protein in kidney tissue., [RefSeq, PubMed]; Multifunctional aminotransferase with a broad substrate specificity (PubMed:23023372, PubMed:23154179, PubMed:23280748, PubMed:27062388). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:27062388). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (PubMed:27062388). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:23023372, PubMed:23154179, PubMed:23280748). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:23023372)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure., [UniProtKB, UniProtKB, UniProtKB]; Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that diabetes-linked transcription factor HNF4alpha regulates maminotransferase 2etabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate Publication Status: Online-Only, [RefSeq, PubMed]; We experimentally proved the presence of a new pathway of homoarginine catabolism - its transamination by AGXT2 with formation of GOCA and demonstrated that endogenous AGXT2 is required for maintenance of homoarginine levels in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EIZ8", "ec_number_list": [ { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.6.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.40", "type": "external" }, { "id": "2.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008453 alanine-glyoxylate transaminase activity;GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity;GO:0016223 beta-alanine:pyruvate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0009436 glyoxylate catabolic process;GO:0019265 glycine biosynthetic process, by transamination of glyoxylate;GO:0019481 L-alanine catabolic process, by transamination;GO:2001299 N(omega),N(omega)-dimethyl-L-arginine catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3UEG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VA0-1", "uniprot_id": [ { "id": "ACSM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VA0", "type": "external" } ], "mass": 64760.0, "length": 573, "protein_name": "Acyl-coenzyme A synthetase ACSM1, mitochondrial", "gene_name": "Acsm1", "organism": "Mouse", "refseq_name": "acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_473435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473435", "type": "external" } ], "gene_names_uniprotkb": "Acsm1; Bucs1; Lae; Macs1", "gene_names_refseq": "Acas3; Acsm1; Bucs1; Macs", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM1, mitochondrial; 6.2.1.25; 6.2.1.2; Acyl-CoA synthetase medium-chain family member 1; Benzoate--CoA ligase; Butyrate--CoA ligase 1; Butyryl-coenzyme A synthetase 1; Lipoate-activating enzyme; Middle-chain acyl-CoA synthetase 1", "protein_names_refseq": "acetyl-Coenzyme A synthetase 3; acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 1; acyl-coenzyme A synthetase ACSM1, mitochondrial; benzoate--CoA ligase; butyrate--CoA ligase 1; butyryl Coenzyme A synthetase 1; butyryl-coenzyme A synthetase 1; lipoate-activating enzyme; middle-chain acyl-CoA synthetase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:117147); (R-MMU-177135); (R-MMU-177162)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11470804;12709059;16378734;21750661;23576753;23806337;30084848;34428180;37453647", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11470804, PubMed:12709059). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:11470804, PubMed:12709059). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UED4", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0102391 decanoate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2N8-1", "uniprot_id": [ { "id": "ACL6A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2N8", "type": "external" } ], "mass": 47448.0, "length": 429, "protein_name": "Actin-like protein 6A", "gene_name": "Actl6a", "organism": "Mouse", "refseq_name": "actin-like protein 6A", "refseq_ac": [ { "id": "NP_062647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062647", "type": "external" } ], "gene_names_uniprotkb": "Actl6a; Actl6; Baf53a", "gene_names_refseq": "2810432C06Rik; ARP4; Actl6a; Actl6; Baf53a", "protein_names_uniprotkb": "Actin-like protein 6A; 53 kDa BRG1-associated factor A; Actin-related protein Baf53a; BAF53A; BRG1-associated factor 53A", "protein_names_refseq": "53 kDa BRG1-associated factor A; BRG1-associated factor 53A; BRG1/brm-associated factor 53A; actin-like 6; actin-like protein 6A; actin-related protein Baf53a", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:56456); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5696394); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "17640523;21750661;22952240;25428506;26601204;29374058;30084848;33602870;34428180;9845365", "class_list": "", "function": "BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex., [RefSeq, PubMed]; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1W3;Q99M56", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016514 SWI/SNF complex;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0003407 neural retina development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z2N8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4F5-1", "uniprot_id": [ { "id": "ABHDB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4F5", "type": "external" } ], "mass": 33561.0, "length": 307, "protein_name": "sn-1-specific diacylglycerol lipase ABHD11", "gene_name": "Abhd11", "organism": "Mouse", "refseq_name": "sn-1-specific diacylglycerol lipase ABHD11 isoform 1", "refseq_ac": [ { "id": "NP_660250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660250", "type": "external" } ], "gene_names_uniprotkb": "Abhd11; Wbscr21", "gene_names_refseq": "1110054D16Rik; A630008N09Rik; Abhd11; Wbscr21", "protein_names_uniprotkb": "sn-1-specific diacylglycerol lipase ABHD11; 3.1.1.116; Abhydrolase domain-containing protein 11; Alpha/beta hydrolase domain-containing protein 11; Williams-Beuren syndrome chromosomal region 21 protein homolog", "protein_names_refseq": "Williams Beuren syndrome chromosome region 21; Williams-Beuren syndrome chromosomal region 21 protein homolog; Williams-Beuren syndrome critical region 21; abhydrolase domain-containing protein 11; alpha/beta hydrolase domain-containing protein 11; protein ABHD11; sn-1-specific diacylglycerol lipase ABHD11 isoform 1; sn-1-specific diacylglycerol lipase ABHD11", "tax_id": 10090, "disease": "", "pathway": " (mmu:68758)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12073013;17215164;21750661;23806337;25619660;32579589;32733886", "class_list": "", "function": "ABHD11, a new diacylglycerol lipase involved in weight gain regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (By similarity). 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (By similarity). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (PubMed:32733886)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Loss lncRNA Abhd11os likely contribute to striatal vulnerability in HD and lncRNA may play crucial roles in neurodegenerative diseases., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" } ], "go_molecular_function": "GO:0016298 lipase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K4F5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07356-1", "uniprot_id": [ { "id": "ANXA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P07356", "type": "external" } ], "mass": 38676.0, "length": 339, "protein_name": "Annexin A2", "gene_name": "Anxa2", "organism": "Mouse", "refseq_name": "annexin A2", "refseq_ac": [ { "id": "NP_031611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031611", "type": "external" } ], "gene_names_uniprotkb": "Anxa2; Anx2; Cal1h", "gene_names_refseq": "Anxa2; Cal1h; PAP-IV; p36", "protein_names_uniprotkb": "Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; PAP-IV; Placental anticoagulant protein IV; Protein I; p36", "protein_names_refseq": "33-kDa calcimedin; 33-kDa lymphocyte Ca<2+>- binding protein; 33kDa lymphocyte Ca<2+>- binding protein; 36-kDa calelectrin; annexin A2; annexin II; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; placental anticoagulant protein IV; protein I", "tax_id": 10090, "disease": "osteonecrosis (Disease Ontology:DOID:10159); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); hypothyroidism (Disease Ontology:DOID:1459); invasive ductal carcinoma (Disease Ontology:DOID:3008); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (mmu:12306); (R-MMU-6798695); (R-MMU-75205); (R-MMU-9860927)", "pathway_count": 4, "publication_count": 37, "publication_id_list": "14506282;14702107;15592455;16139798;19144319;2138915;21540332;21645192;21750661;22453828;22645316;22848640;23806337;24788674;25153642;26371245;26527544;26740625;27045038;27371724;30084848;3013423;31219806;34428180;34887587;35257889;36210013;36288343;37453647;37507081;37828378;38481805;38605477;39384746;39627609;39927985;8634333", "class_list": "", "function": "(Microbial infection) Contributes to protection against Pseudomonas aeruginosa infection by regulating autophagy via the AKT1-mTOR-ULK1/2 signaling pathway and activation of Rho GTPases via FAM13A-mediated mechanism., [UniProtKB, PubMed]; (Microbial infection) Promotes macrophage phagocytic efficiency towards Cryptococcus neoformans and ability to control fungal infection inside the cells., [UniProtKB, PubMed]; (Microbial infection) Protects against Klebsiella pneumoniae infection (PubMed:26527544). Attenuates bacteria-induced pulmonary inflammation and promotes intro-abdominal pathogen clearance (PubMed:26527544). Promotes anti-inflammatory responses by facilitating TLR4 internalization and translocation into early endosomal membranes; this leads to activation of TRAM-dependent endosomal signaling and release of anti-inflammatory cytokines (PubMed:26527544)., [UniProtKB, PubMed]; (Microbial infection) Regulates the formation of the NLRC4 inflammasome triggered by Anaplasma phagocytophilum infection., [UniProtKB, PubMed]; Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (PubMed:22453828). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (PubMed:14702107)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007155 cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P07356-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51174-1", "uniprot_id": [ { "id": "ACADL_MOUSE", "url": "https://www.uniprot.org/uniprot/P51174", "type": "external" } ], "mass": 47908.0, "length": 430, "protein_name": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadl", "organism": "Mouse", "refseq_name": "long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031407", "type": "external" } ], "gene_names_uniprotkb": "Acadl", "gene_names_refseq": "Acadl; LCAD", "protein_names_uniprotkb": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; 1.3.8.8; LCAD; Medium-chain acyl-CoA dehydrogenase, mitochondrial", "protein_names_refseq": "acetyl-Coenzyme A dehydrogenase, long-chain; long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; long-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "very long chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080155)", "pathway": " (mmu:11363); (R-MMU-77285); (R-MMU-77310)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "21183079;21750661;23576753;23806337;24121500;25605945;31219806;33300544;34428180;36210013;36288343;36810848;37453647;37507081;39927985;8530022;9545492;9861014", "class_list": "", "function": "Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase activity overlaps with that of ACADV and ACAD9, acting on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:9861014). Can use (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate as substrate in vitro (which is not primarily used for energy but mainly beta-oxidized in the peroxisomes). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Plays a primary role in FAO in tissues where it is the main long-chain ACAD expressed. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase acts on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity., [UniProtKB, UniProtKB]; The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGC6;O35302;Q8QZR6;Q9CU29;Q9DB83", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" } ], "go_molecular_function": "GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0009062 fatty acid catabolic process;GO:0009409 response to cold;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P51174-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48410-1", "uniprot_id": [ { "id": "ABCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48410", "type": "external" } ], "mass": 81859.0, "length": 736, "protein_name": "ATP-binding cassette sub-family D member 1", "gene_name": "Abcd1", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family D member 1", "refseq_ac": [ { "id": "NP_031461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031461", "type": "external" } ], "gene_names_uniprotkb": "Abcd1; Aldgh; Ald", "gene_names_refseq": "ALDP; Abcd1; Aldgh; Ald", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; ALDP; Adrenoleukodystrophy protein", "protein_names_refseq": "ATP-binding cassette sub-family D member 1; ATP-binding cassette, sub-family D (ALD), member 1; X-linked adrenoleukodystrophy (ALD) gene homolog; adrenoleukodystrophy protein", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (mmu:11666); (R-MMU-1369062); (R-MMU-2046105); (R-MMU-2046106); (R-MMU-390247); (R-MMU-9603798)", "pathway_count": 6, "publication_count": 31, "publication_id_list": "10504404;11875044;15276650;15489218;18344354;18723473;18854420;20484733;21750661;21952136;22299025;22521832;22872234;23123468;23604518;25255441;25428506;25583114;25605945;26108493;30084848;30779550;31219806;34203471;34428180;37507081;38146202;7894167;9126326;9256488;9418970", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Has fatty acyl-CoA thioesterase (ACOT) and ATPase activities. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:18854420, PubMed:23123468, PubMed:23604518, PubMed:25255441, PubMed:25583114, PubMed:26108493, PubMed:9126326, PubMed:9256488, PubMed:9418970). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:15489218, PubMed:26108493). Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization (PubMed:18344354, PubMed:22521832, PubMed:23604518, PubMed:25583114). And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Increased neurotoxicity of high-density lipoprotein secreted from murine reactive astrocytes deficient in a peroxisomal very-long-chain fatty acid transporter Abcd1., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in the human gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY41;Q9QZ32", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0051900 regulation of mitochondrial depolarization;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0032000 positive regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P48410-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PU5-1", "uniprot_id": [ { "id": "ACBG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PU5", "type": "external" } ], "mass": 80426.0, "length": 721, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG1", "gene_name": "Acsbg1", "organism": "Mouse", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG1", "refseq_ac": [ { "id": "NP_444408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444408", "type": "external" } ], "gene_names_uniprotkb": "Acsbg1; Kiaa0631; Lpd", "gene_names_refseq": "Acsbg1; BG1; Bgm; E230019G03Rik; GR-LACS; Lpd", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG1; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 1; GR-LACS; Gonadotropin-regulated long chain acyl CoA synthetase; Lipidosin; mBG1", "protein_names_refseq": "bubblegum; gonadotropin-regulated long chain acyl CoA synthetase; lipidosin; lipidosis-related protein lipidosin; lipodisin; long-chain-fatty-acid--CoA ligase ACSBG1", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (mmu:94180); (R-MMU-75876)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11112418;12975357;14516277;16125341;16452087;16469493;18034455;21183079;21750661;30084848;34428180;34758300", "class_list": "", "function": "Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis., [RefSeq, PubMed]; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity) (PubMed:11112418, PubMed:12975357, PubMed:14516277). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:11112418, PubMed:14516277)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Expression pattern and localization of bubblegum to microsomes., [RefSeq, PubMed]; In neurons, mBG1-activated long-chain fatty acids are directed toward mitochondrial degradation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ79", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0051384 response to glucocorticoid;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99PU5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4Z2-1", "uniprot_id": [ { "id": "ACACB_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4Z2", "type": "external" } ], "mass": 275750.0, "length": 2448, "protein_name": "Acetyl-CoA carboxylase 2", "gene_name": "Acacb", "organism": "Mouse", "refseq_name": "acetyl-CoA carboxylase 2 isoform 2", "refseq_ac": [ { "id": "NP_598665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598665", "type": "external" } ], "gene_names_uniprotkb": "Acacb; Acc2; Accb", "gene_names_refseq": "Acacb; Acc2; Accb", "protein_names_uniprotkb": "Acetyl-CoA carboxylase 2; 6.4.1.2; ACC-beta", "protein_names_refseq": "ACC-beta; acetyl-CoA carboxylase 2 isoform 2; acetyl-CoA carboxylase 2", "tax_id": 10090, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:100705); (R-MMU-196780); (R-MMU-200425)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10677481;11283375;12920182;15677334;17242355;18487439;20368432;21183079;21750661;21987372;22362781;22730442;24913514;25428506;26156967;30084848;34418053;34428180;37507081", "class_list": "", "function": "ACC2 plays an essential role in controlling fatty acid oxidation and is a potential target in therapy against obesity and related diseases., [RefSeq, PubMed]; Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (By similarity). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (By similarity). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (PubMed:24913514). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (PubMed:24913514)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6JIZ0", "ec_number_list": [ { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0009374 biotin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex", "go_biological_process": "GO:0046322 negative regulation of fatty acid oxidation;GO:0051289 protein homotetramerization;GO:0006084 acetyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0010884 positive regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "E9Q4Z2-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62259-1", "uniprot_id": [ { "id": "1433E_MOUSE", "url": "https://www.uniprot.org/uniprot/P62259", "type": "external" } ], "mass": 29174.0, "length": 255, "protein_name": "14-3-3 protein epsilon", "gene_name": "Ywhae", "organism": "Mouse", "refseq_name": "14-3-3 protein epsilon", "refseq_ac": [ { "id": "NP_033562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033562", "type": "external" } ], "gene_names_uniprotkb": "Ywhae", "gene_names_refseq": "Ywhae", "protein_names_uniprotkb": "14-3-3 protein epsilon; 14-3-3E", "protein_names_refseq": "14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide", "tax_id": 10090, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); left ventricular noncompaction (Disease Ontology:DOID:0060480)", "pathway": " (mmu:22627); (R-MMU-111447); (R-MMU-2028269); (R-MMU-205025); (R-MMU-2565942); (R-MMU-3371453); (R-MMU-3371511); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-75035); (R-MMU-8854518); (R-MMU-8876198)", "pathway_count": 17, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10409742;11278287;11471062;11533041;12796778;15722337;17320046;21078877;21183079;21540332;21750661;22645316;24788674;25605945;26047703;26495903;26740625;28528544;30031227;30611118;30973865;31219806;32152506;34428180;35820727;36288343;37453647;37507081;39927985;7750640", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P29360;P42655;Q63631", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0007165 signal transduction;GO:0000165 MAPK cascade;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P62259-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2L6-1", "uniprot_id": [ { "id": "AGRF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2L6", "type": "external" } ], "mass": 77331.0, "length": 698, "protein_name": "Adhesion G protein-coupled receptor F4", "gene_name": "Adgrf4", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor F4 precursor", "refseq_ac": [ { "id": "NP_001276428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276428", "type": "external" } ], "gene_names_uniprotkb": "Adgrf4; Gpr115", "gene_names_refseq": "4632435A09Rik; Adgrf4; Gpr115", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F4; G protein-coupled receptor 115", "protein_names_refseq": "G protein coupled receptor Gpr115; G protein-coupled receptor 115; adhesion G protein-coupled receptor F4 precursor; probable G-protein coupled receptor 115", "tax_id": 10090, "disease": "", "pathway": " (mmu:78249)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22837050;32868297", "class_list": "", "function": "G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts., [RefSeq, PubMed]; Orphan receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q5FW81", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0034505 tooth mineralization;GO:0003094 glomerular filtration;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D2L6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V24-1", "uniprot_id": [ { "id": "ABCA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V24", "type": "external" } ], "mass": 236884.0, "length": 2159, "protein_name": "ATP-binding cassette sub-family A member 7", "gene_name": "Abca7", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family A member 7 isoform 2", "refseq_ac": [ { "id": "NP_038878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038878", "type": "external" } ], "gene_names_uniprotkb": "Abca7", "gene_names_refseq": "ABCX; Abc51; Abca7", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 7", "protein_names_refseq": "ATP-binding cassette sub-family A member 7 isoform 2; ATP-binding cassette, sub-family A (ABC1), member 7", "tax_id": 10090, "disease": "Alzheimer's disease 9 (Disease Ontology:DOID:0111364)", "pathway": " (mmu:27403); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10708515;11435699;12917409;15550377;16445568;16908670;19144319;20495215;21750661;26260791;27030769;27472885;28091533;30899004;31219806;34203471;34428180;38135757;38506634", "class_list": "", "function": "ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism., [RefSeq, PubMed]; ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues, [RefSeq, PubMed]; Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:15550377, PubMed:16908670, PubMed:20495215, PubMed:27030769, PubMed:27472885). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (PubMed:28091533). Plays a role in phagocytosis of apoptotic cells by macrophages (PubMed:16908670). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (PubMed:20495215). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (PubMed:27472885). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791, PubMed:27030769)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The Abca7[V1613M] variant reduces Abeta generation, plaque load, and neuronal damage., [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. Defects in this gene cause an increase in amyloid-beta deposits in a mouse model of Alzheimer's disease, and a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jan 2017]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9JL36", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0005548 phospholipid transporter activity;GO:0034188 apolipoprotein A-I receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0007613 memory;GO:0008542 visual learning;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q91V24-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC29-1", "uniprot_id": [ { "id": "ABCB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC29", "type": "external" } ], "mass": 93770.0, "length": 842, "protein_name": "ATP-binding cassette sub-family B member 6", "gene_name": "Abcb6", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family B member 6", "refseq_ac": [ { "id": "NP_076221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076221", "type": "external" } ], "gene_names_uniprotkb": "Abcb6", "gene_names_refseq": "1200005B17Rik; Abcb6", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 6; 7.6.2.5; ABC-type heme transporter ABCB6", "protein_names_refseq": "ABC-type heme transporter ABCB6; ATP-binding cassette sub-family B member 6, mitochondrial; ATP-binding cassette sub-family B member 6; ATP-binding cassette, sub-family B (MDR/TAP), member 6", "tax_id": 10090, "disease": "dyschromatosis universalis hereditaria (Disease Ontology:DOID:0060304)", "pathway": " (mmu:74104); (R-MMU-1369007)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "17006453;21199866;21266531;21750661;22294697;22655043;23519333;25428506;26495903;27507172;30084848;30779550;31219806;34428180;35820727", "class_list": "", "function": "ABCB6 is uniquely located in the outer mitochondrial membrane and is required for mitochondrial porphyrin uptake, [RefSeq, PubMed]; ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:27507172). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:17006453, PubMed:22294697). May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (By similarity). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (By similarity). In addition may play a role in the transition metal homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Abcb6 is the sole ATP-dependent porphyrin importer, and loss of Abcb6 produces up-regulation of heme and iron pathways necessary for normal development., [RefSeq, PubMed]; Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8., [RefSeq, PubMed]; Homozygous disruption of the Abcb6 gene in mice exacerbates porphyria phenotypes in the mouse model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7N5;Q3UAZ6", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015439 ABC-type heme transporter activity;GO:0015562 efflux transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006878 intracellular copper ion homeostasis;GO:0055085 transmembrane transport;GO:0007420 brain development;GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9DC29-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHW9-1", "uniprot_id": [ { "id": "AL1A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHW9", "type": "external" } ], "mass": 56157.0, "length": 512, "protein_name": "Retinaldehyde dehydrogenase 3", "gene_name": "Aldh1a3", "organism": "Mouse", "refseq_name": "retinaldehyde dehydrogenase 3", "refseq_ac": [ { "id": "NP_444310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444310", "type": "external" } ], "gene_names_uniprotkb": "Aldh1a3; Aldh6; Raldh3", "gene_names_refseq": "ALDH6; Aldh1a3; RALDH3; V1", "protein_names_uniprotkb": "Retinaldehyde dehydrogenase 3; 1.2.1.36; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; RALDH-3; RalDH3", "protein_names_refseq": "RALDH-3; aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase-6; retinaldehyde dehydrogenase 3", "tax_id": 10090, "disease": "isolated microphthalmia 8 (Disease Ontology:DOID:0060841)", "pathway": " (mmu:56847); (R-MMU-5365859)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10906479;11013254;11025231;11044606;14623956;15911617;21750661;23536097;35098344", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:11013254, PubMed:11044606, PubMed:14623956, PubMed:15911617). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (PubMed:14623956)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQP7;Q9JI72", "ec_number_list": [ { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043584 nose development;GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0043065 positive regulation of apoptotic process;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JHW9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZS1-1", "uniprot_id": [ { "id": "AL1B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZS1", "type": "external" } ], "mass": 57553.0, "length": 519, "protein_name": "Aldehyde dehydrogenase family 1 member B1, mitochondrial", "gene_name": "Aldh1b1", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase X, mitochondrial precursor", "refseq_ac": [ { "id": "NP_082546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082546", "type": "external" } ], "gene_names_uniprotkb": "Aldh1b1", "gene_names_refseq": "2700007F14Rik; Aldh1b1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 1 member B1, mitochondrial; 1.2.1.28; 1.2.1.36; 1.2.1.3; 1.7.1.-; Nitroglycerin reductase ALDH1B1", "protein_names_refseq": "aldehyde dehydrogenase X, mitochondrial precursor; aldehyde dehydrogenase X, mitochondrial; aldehyde dehydrogenase family 1 member B1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:72535); (R-MMU-71384); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21750661;23142317;23576753;23806337;25428506;33300544;34428180;37395714;37453647;37507081;38194477", "class_list": "", "function": "ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools, [RefSeq, PubMed]; Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation., [RefSeq, PubMed]; Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes. Shows an absolute preference for NAD(+) as no activity is detected with NADP(+). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro. Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency. In vitro, it can also display a nitroglycerin reductase activity. Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo., [UniProtKB, UniProtKB]; The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAH5", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CZS1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70456-1", "uniprot_id": [ { "id": "1433S_MOUSE", "url": "https://www.uniprot.org/uniprot/O70456", "type": "external" } ], "mass": 27706.0, "length": 248, "protein_name": "14-3-3 protein sigma", "gene_name": "Sfn", "organism": "Mouse", "refseq_name": "14-3-3 protein sigma", "refseq_ac": [ { "id": "NP_061224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061224", "type": "external" } ], "gene_names_uniprotkb": "Sfn; Mkrn3", "gene_names_refseq": "14-3-3; Er; Mme1; Sfn; Ywhas", "protein_names_uniprotkb": "14-3-3 protein sigma; Stratifin", "protein_names_refseq": "14-3-3 protein sigma; 14-3-3 sigma protein; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:55948); (R-MMU-111447); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-6804114); (R-MMU-75035); (R-MMU-9614399)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "16710422;20478393;26047703;34428180", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (By similarity). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (By similarity). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (By similarity). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (PubMed:16710422). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (By similarity). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (By similarity). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEZ1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0050815 phosphoserine residue binding;GO:0051219 phosphoprotein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007165 signal transduction;GO:0030307 positive regulation of cell growth;GO:0031424 keratinization;GO:0045785 positive regulation of cell adhesion;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70456-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61982-1", "uniprot_id": [ { "id": "1433G_MOUSE", "url": "https://www.uniprot.org/uniprot/P61982", "type": "external" } ], "mass": 28303.0, "length": 247, "protein_name": "14-3-3 protein gamma", "gene_name": "Ywhag", "organism": "Mouse", "refseq_name": "14-3-3 protein gamma", "refseq_ac": [ { "id": "NP_061359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061359", "type": "external" } ], "gene_names_uniprotkb": "Ywhag", "gene_names_refseq": "14-3-3gamma; D7Bwg1348e; Ywhag", "protein_names_uniprotkb": "14-3-3 protein gamma", "protein_names_refseq": "14-3-3 gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 56 (Disease Ontology:DOID:0080282); intellectual disability (Disease Ontology:DOID:1059); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949)", "pathway": " (mmu:22628); (R-MMU-111447); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-75035); (R-MMU-8854518); (R-MMU-9614399); (R-MMU-9929491)", "pathway_count": 14, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;12176032;18034455;18250455;19224205;20173027;20478393;20484733;21183079;21952136;25086053;25428506;25605945;26047703;26495903;26740625;28011936;29121962;29187734;30084848;30779550;31599954;33300544;34428180;35342350;35820727;35984892;36288343;36604743;37453647;37507081;37828378;39927985", "class_list": "", "function": "14-3-3gamma haploinsufficiency leads to altered dopamine pathway and Parkinson's disease-like motor incoordination in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (By similarity). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (By similarity). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity)., [UniProtKB, UniProtKB, PubMed]; MiR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3gamma in early stage of 5xFAD mouse model of Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70457;P35214;Q3UFD6;Q4FK44;Q9UDP2;Q9UN99", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:1904263 positive regulation of TORC1 signaling;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P61982-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68254-1", "uniprot_id": [ { "id": "1433T_MOUSE", "url": "https://www.uniprot.org/uniprot/P68254", "type": "external" } ], "mass": 27778.0, "length": 245, "protein_name": "14-3-3 protein theta", "gene_name": "Ywhaq", "organism": "Mouse", "refseq_name": "14-3-3 protein theta", "refseq_ac": [ { "id": "NP_035869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035869", "type": "external" } ], "gene_names_uniprotkb": "Ywhaq", "gene_names_refseq": "2700028P07Rik; Ywhaq", "protein_names_uniprotkb": "14-3-3 protein theta; 14-3-3 protein tau", "protein_names_refseq": "14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 tau; 14-3-3 theta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:22630); (R-MMU-111447); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-75035); (R-MMU-9614399)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21183079;25428506;25605945;26047703;33413679;34203471;34428180;36210013;37453647;37507081;38366598;9197417;9211421", "class_list": "", "function": "14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model. Publication Status: Online-Only, [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)., [UniProtKB]; Targeting 14-3-3theta;-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P35216;Q3TW69;Q3UJN5;Q5SP76;Q5U423;Q66JR6", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006605 protein targeting;GO:0045892 negative regulation of DNA-templated transcription;GO:0007264 small GTPase-mediated signal transduction;GO:0034766 negative regulation of monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P68254-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68510-1", "uniprot_id": [ { "id": "1433F_MOUSE", "url": "https://www.uniprot.org/uniprot/P68510", "type": "external" } ], "mass": 28212.0, "length": 246, "protein_name": "14-3-3 protein eta", "gene_name": "Ywhah", "organism": "Mouse", "refseq_name": "14-3-3 protein eta", "refseq_ac": [ { "id": "NP_035868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035868", "type": "external" } ], "gene_names_uniprotkb": "Ywhah", "gene_names_refseq": "Ywhah", "protein_names_uniprotkb": "14-3-3 protein eta", "protein_names_refseq": "14-3-3 eta; 14-3-3 protein eta", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:22629); (R-MMU-111447); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-75035)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "11533041;12008017;18397886;20478393;25428506;25605945;26047703;26495903;26740625;28011936;33725478;34428180;36610251;37453647;37507081;37828378;38759835;38956068;39627609;9197417;9705322;9738002", "class_list": "", "function": "Activation of PPAR-alpha attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3eta. Publication Status: Online-Only, [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)., [UniProtKB]; The mechanism of 14-3-3eta in thyroxine induced mitophagy in cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P11576;P70198;Q3TGZ9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0006713 glucocorticoid catabolic process;GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P68510-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70445-1", "uniprot_id": [ { "id": "4EBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70445", "type": "external" } ], "mass": 12898.0, "length": 120, "protein_name": "Eukaryotic translation initiation factor 4E-binding protein 2", "gene_name": "Eif4ebp2", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E-binding protein 2", "refseq_ac": [ { "id": "NP_034254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034254", "type": "external" } ], "gene_names_uniprotkb": "Eif4ebp2", "gene_names_refseq": "2810011I19Rik; 4E-BP2; Eif4ebp2; PHAS-II", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E-binding protein 2; 4E-BP2; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2; eIF4E-binding protein 2", "protein_names_refseq": "eIF4E-binding protein 2; eukaryotic translation initiation factor 4E-binding protein 2; phosphorylated heat- and acid-stable protein regulated by insulin 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:13688)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "16237163;17029989;17273556;18515545;19175792;20347422;20424163;21183079;23172145;23184952;24139800;25153642;28135057;36454675;37797700;39467641;8939971", "class_list": "", "function": "4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes., [RefSeq, PubMed]; Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle., [RefSeq, PubMed]; Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:16237163, PubMed:17029989). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:17029989, PubMed:20347422, PubMed:23172145). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (PubMed:20347422, PubMed:23172145, PubMed:24139800). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:8939971)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0071598 neuronal ribonucleoprotein granule", "go_biological_process": "GO:0007613 memory;GO:0048167 regulation of synaptic plasticity;GO:0035176 social behavior;GO:0008286 insulin receptor signaling pathway;GO:0031929 TOR signaling", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P70445-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07417-1", "uniprot_id": [ { "id": "ACADS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07417", "type": "external" } ], "mass": 44890.0, "length": 412, "protein_name": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acads", "organism": "Mouse", "refseq_name": "short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031409", "type": "external" } ], "gene_names_uniprotkb": "Acads", "gene_names_refseq": "Acads; Bcd-1; Bcd1; Hdlq8; SCAD", "protein_names_uniprotkb": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.1; Butyryl-CoA dehydrogenase; SCAD", "protein_names_refseq": "butyryl-CoA dehydrogenase; short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; short-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "short chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080154); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:11409); (R-MMU-77350); (R-MMU-77352)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "21183079;23576753;23806337;28011936;34428180;36288343;37453647;37507081;38898632;39627609;39927985;8276399", "class_list": "", "function": "Aging-induced short-chain acyl-CoA dehydrogenase promotes age-related hepatic steatosis by suppressing lipophagy., [RefSeq, PubMed]; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains., [UniProtKB, UniProtKB]; This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91W85", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046359 butyrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q07417-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14DH7-1", "uniprot_id": [ { "id": "ACSS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14DH7", "type": "external" } ], "mass": 74518.0, "length": 682, "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "Acss3", "organism": "Mouse", "refseq_name": "acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001136276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136276", "type": "external" } ], "gene_names_uniprotkb": "Acss3", "gene_names_refseq": "8430416H19Rik; Acss3; Gm874", "protein_names_uniprotkb": "Acyl-CoA synthetase short-chain family member 3, mitochondrial; 6.2.1.17; 6.2.1.1; Acetate--CoA ligase 3; Propionate--CoA ligase", "protein_names_refseq": "acetate--CoA ligase 3; acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1; acyl-CoA synthetase short-chain family member 3, mitochondrial; propionate--CoA ligase", "tax_id": 10090, "disease": "", "pathway": " (mmu:380660); (R-MMU-77111)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23576753;23806337;37507081;37979225", "class_list": "", "function": "ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis., [RefSeq, PubMed]; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZX0", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0003987 acetate-CoA ligase activity;GO:0050218 propionate-CoA ligase activity;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q14DH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EG47-1", "uniprot_id": [ { "id": "AAPK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5EG47", "type": "external" } ], "mass": 63929.0, "length": 559, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "Prkaa1", "organism": "Mouse", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1", "refseq_ac": [ { "id": "NP_001013385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013385", "type": "external" } ], "gene_names_uniprotkb": "Prkaa1", "gene_names_refseq": "AMPKalpha1; C130083N04Rik; Prkaa1", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-1; 2.7.11.1; 2.7.11.26; 2.7.11.31; ACACA kinase; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; ACACA kinase; AMP-activated protein kinase, alpha 1 catalytic subunit; AMPK subunit alpha-1; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; tau-protein kinase PRKAA1", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:105787); (R-MMU-1632852); (R-MMU-380972); (R-MMU-5628897); (R-MMU-6804756); (R-MMU-9931269)", "pathway_count": 6, "publication_count": 36, "publication_id_list": "15878856;15980064;16054095;16148943;16308421;16804075;16804077;17227772;17242355;18254724;18439900;19144319;19833968;20173027;20361929;20647423;21183079;21205641;21258367;21459323;21460634;22645316;23283301;23842676;24093678;25002183;28528544;31219806;32912901;34077757;34428180;35820727;36804859;37828378;39695227;39695235", "class_list": "", "function": "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (By similarity). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (By similarity). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:15878856). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (PubMed:16804075, PubMed:16804077). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:16148943, PubMed:16308421, PubMed:20647423, PubMed:21459323). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (PubMed:16148943, PubMed:16308421). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (PubMed:20647423). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:18439900, PubMed:21205641, PubMed:21258367, PubMed:24093678, PubMed:25002183, PubMed:32912901, PubMed:39695235). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641, PubMed:21258367). In that process, it also activates WDR45/WIPI4 (By similarity). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (PubMed:23283301). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (PubMed:19833968). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (PubMed:20361929). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (By similarity). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (By similarity). Phosphorylates ALDH7A1 in response to cellular stress, such as hypoxia or ferroptotic stress, promoting ALDH7A1 recruitment to membranes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0016607 nuclear speck", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:1904263 positive regulation of TORC1 signaling;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904179 positive regulation of adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q5EG47-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60662-1", "uniprot_id": [ { "id": "AKAP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60662", "type": "external" } ], "mass": 93796.0, "length": 849, "protein_name": "A-kinase anchor protein 4", "gene_name": "Akap4", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 4 isoform b", "refseq_ac": [ { "id": "NP_001036007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036007", "type": "external" } ], "gene_names_uniprotkb": "Akap4; Akap82; Fsc1", "gene_names_refseq": "AKAP-4; AKAP82; Akap4; Fsc1; PRKA4; mAKAP82; p82", "protein_names_uniprotkb": "A-kinase anchor protein 4; A-kinase anchor protein 82 kDa; AKAP 82; AKAP-4; Major sperm fibrous sheath protein; PRKA4; Protein kinase A-anchoring protein 4; mAKAP82; p82", "protein_names_refseq": "A kinase (PRKA) anchor protein 4; A kinase anchoring protein 4; A-kinase anchor protein 4 isoform b; A-kinase anchor protein 82 kDa; major sperm fibrous sheath protein; protein kinase A-anchoring protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:11643)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12167408;12606363;23446454;31255637;33486757;34415320;35618043;35967402;37146716;38050179;7711182;8088444;9852104", "class_list": "", "function": "Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS., [RefSeq, PubMed]; Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4. Publication Status: Online-Only, [RefSeq, PubMed]; Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development., [RefSeq, PubMed]; Major structural component of sperm fibrous sheath (PubMed:12167408). Plays a role in sperm motility (PubMed:12167408, PubMed:31255637)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXM7;Q60630;Q8R2G7", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0045184 establishment of protein localization;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q60662-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60876-1", "uniprot_id": [ { "id": "4EBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60876", "type": "external" } ], "mass": 12325.0, "length": 117, "protein_name": "Eukaryotic translation initiation factor 4E-binding protein 1", "gene_name": "Eif4ebp1", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E-binding protein 1", "refseq_ac": [ { "id": "NP_031944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031944", "type": "external" } ], "gene_names_uniprotkb": "Eif4ebp1", "gene_names_refseq": "4e-bp1; Eif4ebp1; PHAS-I", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; eIF4E-binding protein 1", "protein_names_refseq": "eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1", "tax_id": 10090, "disease": "tuberous sclerosis (Disease Ontology:DOID:13515); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:13685); (R-MMU-166208); (R-MMU-72662)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11777913;17273556;18515545;19175792;20670887;21183079;21840999;23077579;24139800;25428506;26359501;30084848;32782141;34428180;35820727;7629182", "class_list": "", "function": "Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDS8;Q9CZ40", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity;GO:0051721 protein phosphatase 2A binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045931 positive regulation of mitotic cell cycle;GO:0071456 cellular response to hypoxia;GO:0071549 cellular response to dexamethasone stimulus;GO:0000082 G1/S transition of mitotic cell cycle;GO:0002192 IRES-dependent translational initiation of linear mRNA", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q60876-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M759-1", "uniprot_id": [ { "id": "AB17B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M759", "type": "external" } ], "mass": 32201.0, "length": 288, "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "Abhd17b", "organism": "Mouse", "refseq_name": "alpha/beta hydrolase domain-containing protein 17B precursor", "refseq_ac": [ { "id": "NP_666208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666208", "type": "external" } ], "gene_names_uniprotkb": "Abhd17b", "gene_names_refseq": "5730446C15Rik; Abhd17b; Cgi67; Fam108b1; Fam108b", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17B; 3.1.2.22; Abhydrolase domain-containing protein 17B", "protein_names_refseq": "Cgi67 serine protease; abhydrolase domain-containing protein 17B; abhydrolase domain-containing protein FAM108B1; alpha/beta hydrolase domain-containing protein 17B precursor; alpha/beta hydrolase domain-containing protein 17B; family with sequence similarity 108, member B; protein ABHD17B", "tax_id": 10090, "disease": "", "pathway": " (mmu:226016); (R-MMU-9648002)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12838346;21183079;21750661;27307232;28521134;31219806", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:27307232). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:27307232). Has depalmitoylating activity towards GAP43 (PubMed:27307232). Has depalmitoylating activity towards MAP6 (PubMed:28521134). Has depalmitoylating activity towards NRAS (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q58EV9;Q8K275", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:1902473 regulation of protein localization to synapse;GO:1902950 regulation of dendritic spine maintenance;GO:0002084 protein depalmitoylation;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7M759-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRK8-1", "uniprot_id": [ { "id": "AAPK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRK8", "type": "external" } ], "mass": 62022.0, "length": 552, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "Prkaa2", "organism": "Mouse", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1", "refseq_ac": [ { "id": "NP_835279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835279", "type": "external" } ], "gene_names_uniprotkb": "Prkaa2", "gene_names_refseq": "2310008I11Rik; A830082D05; AMPKalpha2; Prkaa2", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-2; 2.7.11.1; 2.7.11.31; ACACA kinase; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; ACACA kinase; AMPK subunit alpha-2; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:108079); (R-MMU-1632852); (R-MMU-163680); (R-MMU-200425); (R-MMU-380972); (R-MMU-5628897); (R-MMU-6804756); (R-MMU-9759194); (R-MMU-9931269)", "pathway_count": 9, "publication_count": 48, "publication_id_list": "12444247;12511592;15331533;15561936;15980064;16148943;16308421;16804075;16804077;17242355;17609368;18254724;18276828;18439900;19131647;19833968;20299472;20361929;20497424;20647423;21079619;21183079;21205641;21258367;21454484;21459323;21460634;21980456;22357971;22412912;22517326;23332761;23842676;24093678;25002183;26986624;27416746;27737949;27802388;30059200;30201684;32912901;34077757;34167027;34428180;37507081;39695227;39695235", "class_list": "", "function": "By sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis., [RefSeq, PubMed]; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (By similarity). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (By similarity). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:15331533, PubMed:15561936). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (PubMed:16804075, PubMed:16804077). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:17609368, PubMed:20647423, PubMed:21454484, PubMed:21459323). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (PubMed:16148943, PubMed:16308421). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (PubMed:20647423). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:18439900, PubMed:21205641, PubMed:21258367, PubMed:24093678, PubMed:25002183, PubMed:32912901, PubMed:39695235). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641, PubMed:21258367). In that process, it also activates WDR45/WIPI4 (By similarity). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (PubMed:19833968). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (PubMed:20361929). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (By similarity). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (PubMed:23332761). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (PubMed:23332761). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (By similarity). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (By similarity). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Extramuscular AMPKalpha2 catalytic subunit has a role in whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ASQ8;Q3UYM4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:1904263 positive regulation of TORC1 signaling;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q8BRK8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K370-1", "uniprot_id": [ { "id": "ACD10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K370", "type": "external" } ], "mass": 118979.0, "length": 1069, "protein_name": "Acyl-CoA dehydrogenase family member 10", "gene_name": "Acad10", "organism": "Mouse", "refseq_name": "acyl-CoA dehydrogenase family member 10", "refseq_ac": [ { "id": "NP_082313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082313", "type": "external" } ], "gene_names_uniprotkb": "Acad10", "gene_names_refseq": "2410021P16Rik; Acad10", "protein_names_uniprotkb": "Acyl-CoA dehydrogenase family member 10; 1.3.99.-; ACAD-10", "protein_names_refseq": "ACAD-10; acyl-CoA dehydrogenase family member 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:71985); (R-MMU-77289)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "23576753;23806337;25605945;28120165;31219806;33301490;34428180;35820727;36184612;36288343", "class_list": "", "function": "ACAD10 protein expression and Neurobehavioral assessment of Acad10-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; Acad10 mice accumulate excess abdominal adipose tissue, develop an early inflammatory liver process, exhibit fasting rhabdomyolysis, and have abnormal skeletal muscle mitochondria. Identify Acad10 as a genetic determinant of type 2 diabetes in mice., [RefSeq, PubMed]; Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA., [UniProtKB]; The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWQ0;Q8K313", "ec_number_list": [ { "id": "1.3.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.99.-", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K370-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCW8-1", "uniprot_id": [ { "id": "ACSF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCW8", "type": "external" } ], "mass": 67951.0, "length": 615, "protein_name": "Medium-chain acyl-CoA ligase ACSF2, mitochondrial", "gene_name": "Acsf2", "organism": "Mouse", "refseq_name": "medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_722502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722502", "type": "external" } ], "gene_names_uniprotkb": "Acsf2", "gene_names_refseq": "Acsf2", "protein_names_uniprotkb": "Medium-chain acyl-CoA ligase ACSF2, mitochondrial; 6.2.1.2", "protein_names_refseq": "acyl-CoA synthetase family member 2, mitochondrial; medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor; medium-chain acyl-CoA ligase ACSF2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:264895); (R-MMU-77289)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "23576753;23806337;25428506;28135057;28528544;30084848;34428180;36764625;37453647;37507081;38676722;39627609;39666251", "class_list": "", "function": "ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes., [RefSeq, PubMed]; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation., [UniProtKB, UniProtKB]; Inhibition of ACSF2 protects against renal ischemia/reperfusion injury via mediating mitophagy in proximal tubular cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDU9;Q3U5G9", "ec_number_list": [ { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VCW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZE5-1", "uniprot_id": [ { "id": "AGRE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZE5", "type": "external" } ], "mass": 77045.0, "length": 689, "protein_name": "Adhesion G protein-coupled receptor E4", "gene_name": "Adgre4", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor E4 precursor", "refseq_ac": [ { "id": "NP_631877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631877", "type": "external" } ], "gene_names_uniprotkb": "Adgre4; Emr4", "gene_names_refseq": "Adgre4; D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor E4; EGF-like module receptor 4; EGF-like module-containing mucin-like hormone receptor-like 4; F4/80-like-receptor; Seven-span membrane protein FIRE", "protein_names_refseq": "EGF-like module containing, mucin-like, hormone receptor-like sequence 4; EGF-like module receptor 4; EGF-like module-containing mucin-like hormone receptor-like 4; F4/80-like-receptor; adhesion G protein-coupled receptor E4 precursor; seven-span membrane protein FIRE", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:52614)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11564768;12023293;12709506;16753812;20173027;26495903;30084848;30779550;34428180", "class_list": "", "function": "Activated in mucosal [and cutaneous]wounds, [RefSeq, PubMed]; May mediate the cellular interaction between myeloid cells and B-cells., [UniProtKB, PubMed]; The first EGF-TM7 receptor known to mediate the cellular interaction between myeloid cells and B cells, [RefSeq, PubMed]; Two alternatively spliced human FIRE transcripts were identified, neither are predicted to express the TM7 cassette. Thus, if the human FIRE exists, it is likely to be expressed as a soluble secreted molecule., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1I7;Q8BYX0;Q8VIM3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91ZE5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J27-1", "uniprot_id": [ { "id": "ACATN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J27", "type": "external" } ], "mass": 61075.0, "length": 550, "protein_name": "Acetyl-coenzyme A transporter 1", "gene_name": "Slc33a1", "organism": "Mouse", "refseq_name": "acetyl-coenzyme A transporter 1 isoform 1", "refseq_ac": [ { "id": "NP_001258964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258964", "type": "external" } ], "gene_names_uniprotkb": "Slc33a1; Acatn", "gene_names_refseq": "Acatn; D630022N01Rik; Slc33a1", "protein_names_uniprotkb": "Acetyl-coenzyme A transporter 1; AT-1; Acetyl-CoA transporter 1; Solute carrier family 33 member 1", "protein_names_refseq": "AT-1; acetyl-CoA transporter 1; acetyl-coenzyme A transporter 1 isoform 1; acetyl-coenzyme A transporter 1; solute carrier family 33 member 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 42 (Disease Ontology:DOID:0110794)", "pathway": " (mmu:11416); (R-MMU-425397)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10570973;10812068;17208939;17242355;20826464;21183079;24828632;31477734;33080365;34428180;36210013;36852467", "class_list": "glycogene", "function": "Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrate, such as BACE1 (PubMed:24828632). Necessary for O-acetylation of gangliosides (PubMed:10570973)., [UniProtKB, UniProtKB, PubMed, PubMed]; Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis., [RefSeq, PubMed]; Results suggest that solute carrier family 33 (acetyl-CoA transporter) member 1 (AT-1) acts as an important metabolic regulator that maintains acetyl-CoA homeostasis by promoting functional crosstalk between different intracellular organelles. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTN1", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008521 acetyl-CoA transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035348 acetyl-CoA transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99J27-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99L13-1", "uniprot_id": [ { "id": "3HIDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99L13", "type": "external" } ], "mass": 35440.0, "length": 335, "protein_name": "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "gene_name": "Hibadh", "organism": "Mouse", "refseq_name": "3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_663542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663542", "type": "external" } ], "gene_names_uniprotkb": "Hibadh", "gene_names_refseq": "6430402H10Rik; Hibadh", "protein_names_uniprotkb": "3-hydroxyisobutyrate dehydrogenase, mitochondrial; 1.1.1.31; HIBADH", "protein_names_refseq": "3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor; 3-hydroxyisobutyrate dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:58875); (R-MMU-70895)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;23576753;23806337;31219806;34428180;37453647;37507081;39927985", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJY2", "ec_number_list": [ { "id": "1.1.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.31", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0008442 3-hydroxyisobutyrate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99L13-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQV8-1", "uniprot_id": [ { "id": "1433B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQV8", "type": "external" } ], "mass": 28086.0, "length": 246, "protein_name": "14-3-3 protein beta/alpha", "gene_name": "Ywhab", "organism": "Mouse", "refseq_name": "14-3-3 protein beta/alpha", "refseq_ac": [ { "id": "NP_061223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061223", "type": "external" } ], "gene_names_uniprotkb": "Ywhab", "gene_names_refseq": "1300003C17Rik; 14-3-3b; Ywhab", "protein_names_uniprotkb": "14-3-3 protein beta/alpha; KCIP-1; Protein kinase C inhibitor protein 1", "protein_names_refseq": "14-3-3 protein beta/alpha; 14-3-3 protein beta; KCIP-1; protein kinase C inhibitor protein 1; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:54401); (R-MMU-111447); (R-MMU-165159); (R-MMU-170968); (R-MMU-2028269); (R-MMU-392517); (R-MMU-450385); (R-MMU-450513); (R-MMU-5625740); (R-MMU-5628897); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5675221); (R-MMU-75035); (R-MMU-9614399)", "pathway_count": 15, "publication_count": 17, "publication_id_list": "11875115;12008017;15883195;16800626;18604201;20478393;21750661;25605945;26047703;26740625;33300544;34428180;36210013;36288343;37453647;37507081;9705322", "class_list": "glycogene", "function": "14-3-3 participates in the intracellular trafficking of IRS-1, [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13., [UniProtKB, UniProtKB]; The transcription start site was identified and the polyadenylation signals (AATAAA) were found in exon 2 of the mouse gene. In the 5'-upstream sequence, we found three cis elements including a CRE sequence, a TATA box-like sequence, and a C/EBP element., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70455;Q3TY33;Q3UAN6", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0050815 phosphoserine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006605 protein targeting;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9CQV8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCT1-1", "uniprot_id": [ { "id": "AKCL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCT1", "type": "external" } ], "mass": 34461.0, "length": 301, "protein_name": "1,5-anhydro-D-fructose reductase", "gene_name": "Akr1e2", "organism": "Mouse", "refseq_name": "1,5-anhydro-D-fructose reductase", "refseq_ac": [ { "id": "NP_061347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061347", "type": "external" } ], "gene_names_uniprotkb": "Akr1e2; Akr1cl2; Akr1e1", "gene_names_refseq": "1810061I10Rik; Akr1e1; Akr1e2", "protein_names_uniprotkb": "1,5-anhydro-D-fructose reductase; 1.1.1.263; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E1; Aldo-keto reductase family 1 member E2", "protein_names_refseq": "1,5-anhydro-D-fructose reductase; AF reductase; aldo-keto reductase family 1 member C-like protein 2; aldo-keto reductase family 1 member E2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56043); (R-MMU-70221)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;18323634;30084848;34428180", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol., [UniProtKB, PubMed]; Confirmed that cloned AKR1E1 is mouse ortholog of pig liver 1,5-anhydro-D-fructose reductase based on enzymatic properties of purified recombinant protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09125", "ec_number_list": [ { "id": "1.1.1.263", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.263", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0050571 1,5-anhydro-D-fructose reductase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY30-1", "uniprot_id": [ { "id": "ABCBB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY30", "type": "external" } ], "mass": 146749.0, "length": 1321, "protein_name": "Bile salt export pump", "gene_name": "Abcb11", "organism": "Mouse", "refseq_name": "bile salt export pump", "refseq_ac": [ { "id": "NP_066302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066302", "type": "external" } ], "gene_names_uniprotkb": "Abcb11; Bsep; Spgp", "gene_names_refseq": "ABC16; Abcb11; Bsep; Lith1; PFIC2; PGY4; SPGP", "protein_names_uniprotkb": "Bile salt export pump; 7.6.2.-; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein", "protein_names_refseq": "ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump; sister of P-glycoprotein", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis 2 (Disease Ontology:DOID:0070222); benign recurrent intrahepatic cholestasis 2 (Disease Ontology:DOID:0070232); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:27413); (R-MMU-159418); (R-MMU-193368)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10607905;11172067;14570929;17242355;19228692;22619174;23764895;34428180;38158489;38164042", "class_list": "", "function": "Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:11172067, PubMed:14570929, PubMed:19228692, PubMed:22619174, PubMed:23764895). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (By similarity). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCalpha-associated signalling under cholesterol stimulation., [RefSeq, PubMed]; Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the Expression of ABCB11 via PKC-alpha., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AUN4;Q9QZE8", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015126 canalicular bile acid transmembrane transporter activity;GO:0015432 ABC-type bile acid transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0055085 transmembrane transport;GO:0055088 lipid homeostasis;GO:0015721 bile acid and bile salt transport;GO:0015722 canalicular bile acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QY30-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R078-1", "uniprot_id": [ { "id": "AAKB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R078", "type": "external" } ], "mass": 30308.0, "length": 270, "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "Prkab1", "organism": "Mouse", "refseq_name": "5'-AMP-activated protein kinase subunit beta-1", "refseq_ac": [ { "id": "NP_114075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114075", "type": "external" } ], "gene_names_uniprotkb": "Prkab1", "gene_names_refseq": "1300015D22Rik; E430008F22; Prkab1", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb", "protein_names_refseq": "5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb", "tax_id": 10090, "disease": "", "pathway": " (mmu:19079); (R-MMU-1632852); (R-MMU-380972); (R-MMU-5628897); (R-MMU-6804756); (R-MMU-9931269)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "19131326;19144319;21183079;21460634;21750661;23806337;26359501;34428180;37428711;37507081", "class_list": "", "function": "Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Three-Dimensional Matrix Stiffness Activates the Piezo1-AMPK-Autophagy Axis to Regulate the Cellular Osteogenic Differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YN6", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004679 AMP-activated protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006633 fatty acid biosynthetic process;GO:0035878 nail development;GO:0031669 cellular response to nutrient levels;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R078-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1C8-1", "uniprot_id": [ { "id": "5HT6R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1C8", "type": "external" } ], "mass": 46998.0, "length": 440, "protein_name": "5-hydroxytryptamine receptor 6", "gene_name": "Htr6", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 6", "refseq_ac": [ { "id": "NP_067333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067333", "type": "external" } ], "gene_names_uniprotkb": "Htr6", "gene_names_refseq": "5-HT6; Htr6", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6", "protein_names_refseq": "5-HT-6; 5-hydroxytryptamine receptor 6; serotonin receptor 6", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:15565); (R-MMU-390666); (R-MMU-418555)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11406289;23027611;25078650", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:11406289). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of mTOR signaling (PubMed:23027611)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007612 learning;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0014050 negative regulation of glutamate secretion;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R1C8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00687-1", "uniprot_id": [ { "id": "AMY1_MOUSE", "url": "https://www.uniprot.org/uniprot/P00687", "type": "external" } ], "mass": 57644.0, "length": 511, "protein_name": "Alpha-amylase 1", "gene_name": "Amy1", "organism": "Mouse", "refseq_name": "alpha-amylase 1 precursor", "refseq_ac": [ { "id": "NP_001103975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103975", "type": "external" } ], "gene_names_uniprotkb": "Amy1; Amy-1-a; Amy1a", "gene_names_refseq": "Amy-1; Amy1a; Amy1; C030014B17Rik", "protein_names_uniprotkb": "Alpha-amylase 1; 1,4-alpha-D-glucan glucanohydrolase 1; 3.2.1.1; Salivary and hepatic alpha-amylase", "protein_names_refseq": "1,4-alpha-D-glucan glucanohydrolase 1; alpha-amylase 1 precursor; alpha-amylase 1; alpha-amylase amy1a; salivary and hepatic alpha-amylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:11722); (R-MMU-189085)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;26132294;35820727;36210013;36583994;39627609;6157477;6162108;6162570;6176715", "class_list": "glycogene;glycosylhydrolase", "function": "Our findings suggest that AMY1 copy number differences play a role in childhood-onset obesity but the effect differs between males and females. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921Y7", "ec_number_list": [ { "id": "3.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0016160 amylase activity;GO:0031404 chloride ion binding;GO:0005509 calcium ion binding;GO:0004556 alpha-amylase activity;GO:0043169 cation binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00687-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27040-1", "uniprot_id": [ { "id": "AVR2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P27040", "type": "external" } ], "mass": 60542.0, "length": 536, "protein_name": "Activin receptor type-2B", "gene_name": "Acvr2b", "organism": "Mouse", "refseq_name": "activin receptor type-2B isoform 2 precursor", "refseq_ac": [ { "id": "NP_001300686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300686", "type": "external" } ], "gene_names_uniprotkb": "Acvr2b", "gene_names_refseq": "4930516B21Rik; AI047905; ActRIIB; Acvr2b", "protein_names_uniprotkb": "Activin receptor type-2B; 2.7.11.30; ACTR-IIB; Activin receptor type IIB", "protein_names_refseq": "activin receptor type IIB; activin receptor type-2B isoform 2 precursor; activin receptor type-2B", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); visceral heterotaxy 4 (Disease Ontology:DOID:0051019); right atrial isomerism (Disease Ontology:DOID:0060856); pre-eclampsia (Disease Ontology:DOID:10591); Marfan syndrome (Disease Ontology:DOID:14323)", "pathway": " (mmu:11481); (R-MMU-1502540); (R-MMU-201451)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;1310075;22074949;27502274;36950748;37828378", "class_list": "", "function": "Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway., [RefSeq, PubMed]; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQI1", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0048179 activin receptor complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0007507 heart development;GO:0001822 kidney development;GO:0001974 blood vessel remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27040-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLF1-1", "uniprot_id": [ { "id": "NCEH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLF1", "type": "external" } ], "mass": 45740.0, "length": 408, "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "Nceh1", "organism": "Mouse", "refseq_name": "neutral cholesterol ester hydrolase 1", "refseq_ac": [ { "id": "NP_848887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848887", "type": "external" } ], "gene_names_uniprotkb": "Nceh1; Aadacl1; Kiaa1363", "gene_names_refseq": "Aadacl1; B230106I24Rik; CPO-BP; Nceh1; Nceh", "protein_names_uniprotkb": "Neutral cholesterol ester hydrolase 1; 2-acetyl MAGE hydrolase; 3.1.1.-; 3.1.1.71; Acetylalkylglycerol acetylhydrolase; Arylacetamide deacetylase-like 1; CPO-BP; Chlorpyrifos oxon-binding protein; NCEH", "protein_names_refseq": "2-acetyl MAGE hydrolase; acetylalkylglycerol acetylhydrolase; arylacetamide deacetylase-like 1; chlorpyrifos oxon-binding protein; neutral cholesterol ester hydrolase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320024); (R-MMU-8964038)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;12740587;15840715;16978018;18164358;18782767;19592704;20625037;21750661;24868095;24891333;25428506;28135057;30899004;31219806;32152506;33300544;34428180;38664801;40885482;40997131", "class_list": "glycogene", "function": "Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:18164358, PubMed:20625037). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (PubMed:18782767). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (PubMed:15840715, PubMed:16978018, PubMed:18164358)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis., [RefSeq, PubMed]; NCEH is targeted to the ER of macrophages, where it hydrolyzes CE to deliver cholesterol for efflux out of the cells., [RefSeq, PubMed]; Reducing the cholesteryl ester content of foam cells, Nceh1 may protect against the pro-apoptotic effect of oxysterols and modulate the development of atherosclerosis., [RefSeq, PubMed]; These results suggest that Nceh1 plays a dominant role over Lipe in the hydrolysis of CE and subsequent cholesterol efflux in MPMs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZL0;Q8BZK3", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0017171 serine hydrolase activity;GO:0047378 acetylalkylglycerol acetylhydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0006805 xenobiotic metabolic process;GO:0006470 protein dephosphorylation;GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8BLF1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WC1-1", "uniprot_id": [ { "id": "POTE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WC1", "type": "external" } ], "mass": 70863.0, "length": 640, "protein_name": "Protection of telomeres protein 1", "gene_name": "Pot1", "organism": "Mouse", "refseq_name": "protection of telomeres protein 1", "refseq_ac": [ { "id": "NP_598692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598692", "type": "external" } ], "gene_names_uniprotkb": "Pot1; Pot1a", "gene_names_refseq": "1500031H18Rik; Pot1a; Pot1", "protein_names_uniprotkb": "Protection of telomeres protein 1; POT1-like telomere end-binding protein; mPot1", "protein_names_refseq": "POT1-like telomere end-binding protein; protection of telomeres protein 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); cholecystitis (Disease Ontology:DOID:1949); ovarian cancer (Disease Ontology:DOID:2394); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:101185); (R-MMU-110330); (R-MMU-110331); (R-MMU-171319); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174430); (R-MMU-174437); (R-MMU-2559586); (R-MMU-9670095)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "16839876;16839877;17053789;33711210;34428180;37773433", "class_list": "", "function": "Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity (By similarity)., [UniProtKB]; Our results suggest that POT1a is crucial for the maintenance of both telomere integrity and overall genomic stability., [RefSeq, PubMed]; POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; ShRNA mediated depletion of endogenous Pot1b in Pot1a deficient cells resulted in increased chromosomal aberrations, [RefSeq, PubMed]; The intrinsically disordered N-terminal region of mouse DNA polymerase alpha mediates its interaction with POT1a/b at telomeres., [RefSeq, PubMed]; We conclude that mouse telomeres require two distinct POT1 proteins whereas human telomeres have one., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUH9", "ec_number_list": [], "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0042162 telomeric DNA binding;GO:0043047 single-stranded telomeric DNA binding;GO:0010521 telomerase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000783 nuclear telomere cap complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0016233 telomere capping;GO:0032210 regulation of telomere maintenance via telomerase;GO:0007004 telomere maintenance via telomerase;GO:0032206 positive regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91WC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGY9-1", "uniprot_id": [ { "id": "SC5A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGY9", "type": "external" } ], "mass": 63365.0, "length": 580, "protein_name": "High affinity choline transporter 1", "gene_name": "Slc5a7", "organism": "Mouse", "refseq_name": "high affinity choline transporter 1", "refseq_ac": [ { "id": "NP_071308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071308", "type": "external" } ], "gene_names_uniprotkb": "Slc5a7; Cht1", "gene_names_refseq": "CHT1; Slc5a7", "protein_names_uniprotkb": "High affinity choline transporter 1; CHT; Hemicholinium-3-sensitive choline transporter; Solute carrier family 5 member 7", "protein_names_refseq": "CHT; hemicholinium-3-sensitive choline transporter; high affinity choline transporter 1; solute carrier family 5 member 7", "tax_id": 10090, "disease": "congenital myasthenic syndrome 20 (Disease Ontology:DOID:0110661); autosomal dominant distal hereditary motor neuronopathy 7 (Disease Ontology:DOID:0111199); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:63993); (R-MMU-264642); (R-MMU-9958517)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11709061;15064333;15173594;21750661;25428506", "class_list": "", "function": "High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11709061, PubMed:15173594). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (By similarity). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (By similarity). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (By similarity). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11709061, PubMed:15173594). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99PK3;Q9ESW5", "ec_number_list": [], "go_molecular_function": "GO:0033265 choline binding;GO:0015220 choline transmembrane transporter activity;GO:0005307 choline:sodium symporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42230-1", "uniprot_id": [ { "id": "STA5A_MOUSE", "url": "https://www.uniprot.org/uniprot/P42230", "type": "external" } ], "mass": 90831.0, "length": 793, "protein_name": "Signal transducer and activator of transcription 5A", "gene_name": "Stat5a", "organism": "Mouse", "refseq_name": "signal transducer and activator of transcription 5A isoform 1", "refseq_ac": [ { "id": "NP_035618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035618", "type": "external" } ], "gene_names_uniprotkb": "Stat5a; Mgf; Mpf", "gene_names_refseq": "STAT5; Stat5a", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5A; Mammary gland factor", "protein_names_refseq": "mammary gland factor STAT5A; signal transducer and activator of transcription 5A isoform 1", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); growth hormone insensitivity syndrome with immune dysregulation 1 (Disease Ontology:DOID:0080836); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); prostate cancer (Disease Ontology:DOID:10283); colon adenocarcinoma (Disease Ontology:DOID:234); glioblastoma (Disease Ontology:DOID:3068); invasive lobular carcinoma (Disease Ontology:DOID:3457); gastric adenocarcinoma (Disease Ontology:DOID:3717); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:20850); (R-MMU-1251985); (R-MMU-1266695); (R-MMU-1433557); (R-MMU-186763); (R-MMU-512988); (R-MMU-8854691); (R-MMU-8983432); (R-MMU-8985947); (R-MMU-9020558); (R-MMU-9020958); (R-MMU-982772)", "pathway_count": 12, "publication_count": 40, "publication_id_list": "10508857;11090077;11413148;12388746;12732616;16192273;16837552;17356133;18215306;20696842;21135090;21183079;21262971;21750661;21860432;21949826;22022510;23457589;23565285;24412367;25231404;25428506;25605945;25826077;25880134;26710253;26799659;27173727;28066259;28074064;28329851;28867537;28913408;30084848;30622248;32705545;34428180;7568026;7720707;9528750", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0046543 development of secondary female sexual characteristics;GO:0033026 negative regulation of mast cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P42230-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64729-1", "uniprot_id": [ { "id": "TGFR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64729", "type": "external" } ], "mass": 56179.0, "length": 503, "protein_name": "TGF-beta receptor type-1", "gene_name": "Tgfbr1", "organism": "Mouse", "refseq_name": "TGF-beta receptor type-1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001299797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299797", "type": "external" } ], "gene_names_uniprotkb": "Tgfbr1", "gene_names_refseq": "ALK5; Alk-5; ESK2; TGFR-1; TbetaR-I; TbetaRI; Tgfbr1", "protein_names_uniprotkb": "TGF-beta receptor type-1; 2.7.11.30; ESK2; TGF-beta receptor type I; TGFR-1; TbetaR-I; Transforming growth factor-beta receptor type I", "protein_names_refseq": "TGF-beta receptor type I; TGF-beta receptor type-1 isoform 2 precursor; TGF-beta receptor type-1; transforming growth factor-beta receptor type I", "tax_id": 10090, "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); Loeys-Dietz syndrome 1 (Disease Ontology:DOID:0070235); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); osteochondrodysplasia (Disease Ontology:DOID:2256); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); Lynch syndrome (Disease Ontology:DOID:3883); systemic scleroderma (Disease Ontology:DOID:418); kidney disease (Disease Ontology:DOID:557); Ferguson-Smith tumor (Disease Ontology:DOID:5585); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:21812); (R-MMU-2173788); (R-MMU-2173789); (R-MMU-2173791); (R-MMU-5689880); (R-MMU-9839389)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "12065756;18250455;21750661;26495903;27802388;28011936;31219806;34428180;37828378;8117261;8117262", "class_list": "", "function": "This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]; Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AJN0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0060017 parathyroid gland development;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64729-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31786-1", "uniprot_id": [ { "id": "ACBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P31786", "type": "external" } ], "mass": 10000.0, "length": 87, "protein_name": "Acyl-CoA-binding protein", "gene_name": "Dbi", "organism": "Mouse", "refseq_name": "acyl-CoA-binding protein isoform 2", "refseq_ac": [ { "id": "NP_031856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031856", "type": "external" } ], "gene_names_uniprotkb": "Dbi", "gene_names_refseq": "ACBD1; Acbp; Dbi; EP; endozepine", "protein_names_uniprotkb": "Acyl-CoA-binding protein; ACBP; DBI; Diazepam-binding inhibitor; EP; Endozepine", "protein_names_refseq": "acyl-CoA-binding protein isoform 2; acyl-CoA-binding protein; diazepam binding inhibitor, splice form 1b", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cardiovascular system disease (Disease Ontology:DOID:1287); morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (mmu:13167); (R-MMU-77289)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12106288;16075062;18034455;21750661;23576753;23806337;2615592;34428180;37453647;37507081;39242519", "class_list": "", "function": "Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance. Erratum:[Mol Cancer. 2024 Oct 17;23(1):231. doi: 10.1186/s12943-024-02152-2. PMID: 39420364] Publication Status: Online-Only, [RefSeq, PubMed]; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000062 fatty-acyl-CoA binding;GO:0030156 benzodiazepine receptor binding;GO:0036042 long-chain fatty acyl-CoA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process;GO:0007611 learning or memory;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0001662 behavioral fear response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P31786-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHJ0-1", "uniprot_id": [ { "id": "AAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHJ0", "type": "external" } ], "mass": 103346.0, "length": 959, "protein_name": "AP2-associated protein kinase 1", "gene_name": "Aak1", "organism": "Mouse", "refseq_name": "AP2-associated protein kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_001035195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035195", "type": "external" } ], "gene_names_uniprotkb": "Aak1; Kiaa1048", "gene_names_refseq": "5530400K14Rik; 9630042K20; Aak1; D6Ertd245e; Gm38495; mKIAA1048", "protein_names_uniprotkb": "AP2-associated protein kinase 1; 2.7.11.1; Adaptor-associated kinase 1", "protein_names_refseq": "AP2-associated protein kinase 1 isoform 1; AP2-associated protein kinase 1; adaptor-associated kinase 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:269774); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17242355;19131326;19144319;21183079;21464124;21750661;22517741;22645316;24129315;26495903;29774516;32782141;32848054;33300544;33725478;34428180;34678516;35822049;36288343;36731797;39627609;40021952;40885482", "class_list": "", "function": "Periodic variation in AAK1 expression is closely correlated to the decline in cognition in mouse model of Alzheimer's disease., [RefSeq, PubMed]; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "B2RUJ0;Q3TY53;Q6ZPZ6;Q80XP6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005112 Notch binding;GO:0035612 AP-2 adaptor complex binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0031252 cell leading edge", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0032880 regulation of protein localization;GO:0045747 positive regulation of Notch signaling pathway;GO:0050821 protein stabilization;GO:2000369 regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q3UHJ0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4F7-1", "uniprot_id": [ { "id": "ANR11_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4F7", "type": "external" } ], "mass": 296186.0, "length": 2643, "protein_name": "Ankyrin repeat domain-containing protein 11", "gene_name": "Ankrd11", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 11", "refseq_ac": [ { "id": "NP_001074848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074848", "type": "external" } ], "gene_names_uniprotkb": "Ankrd11", "gene_names_refseq": "2410104C19Rik; 3010027A04Rik; 6330578C09Rik; 9530048I21Rik; Ankrd11; Gm176; Yod", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 11", "protein_names_refseq": "ankyrin repeat domain-containing protein 11", "tax_id": 10090, "disease": "KBG syndrome (Disease Ontology:DOID:14780)", "pathway": " (mmu:77087)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17986521;21183079;21750661;25413698;25556659;31219806;34428180;35820727;36852467;38951500;40997131", "class_list": "", "function": "A Glu->Lys missense mutation in a highly conserved region causes osteopenia and craniofacial abnormalities. Homozygosity causes embryo death. Ankrd11 is a genetic regular of bone homeostasis., [RefSeq, PubMed]; Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (PubMed:25556659). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (By similarity). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (PubMed:17986521)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RY01;Q6PB57", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0060323 head morphogenesis;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0007507 heart development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "E9Q4F7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R400-1", "uniprot_id": [ { "id": "ADIG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R400", "type": "external" } ], "mass": 9362.0, "length": 80, "protein_name": "Adipogenin", "gene_name": "Adig", "organism": "Mouse", "refseq_name": "adipogenin", "refseq_ac": [ { "id": "NP_663610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663610", "type": "external" } ], "gene_names_uniprotkb": "Adig; Smaf1", "gene_names_refseq": "Adig; SMAF-1; Smaf1", "protein_names_uniprotkb": "Adipogenin; SMAF-1; Small adipocyte factor 1", "protein_names_refseq": "adipogenin; small adipocyte factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:246747)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15567149;16132694;21183079;21750661;26427354;33691105;37249025;41196993", "class_list": "", "function": "Adipocyte-specific membrane protein adipogenin may be involved with adipogenesis as one of the regulators of adipose tissue development., [RefSeq, PubMed]; Key regulator of lipid storage that promotes the expansion of lipid droplets during the formation of mature adipocytes (PubMed:16132694, PubMed:33691105, PubMed:41196993). Acts by forming a dodecameric complex with seipin (BSCL2) when adipocytes have differentiated and are undergoing maturation (PubMed:41196993). In the dodecameric complex, ADIG antagonizes the activity of BSCL2 by reducing BSCL2-mediated triacylglycerol nucleation and relieving BSCL2's inhibition of GPAT3 and GPAT4 (PubMed:41196993). GPAT3 and GPAT4 then translocate to lipid droplets, promoting the synthesis of triacylglycerols and the expansion of lipid droplets (PubMed:41196993)., [UniProtKB, PubMed, PubMed, PubMed]; Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion., [RefSeq, PubMed]; Together our findings show that Smaf1 is a novel small protein endogenous to adipocytes and that Smaf1 expression is closely tied to PPARgamma-mediated signals and the adipocyte phenotype., [RefSeq, PubMed]; Transcriptional regulation of adipogenin expression in liver steatosis by hepatic peroxisome proliferator-activated receptor gamma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0045600 positive regulation of fat cell differentiation;GO:0050872 white fat cell differentiation;GO:0050873 brown fat cell differentiation;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R400-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97717-1", "uniprot_id": [ { "id": "ADA1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P97717", "type": "external" } ], "mass": 56418.0, "length": 514, "protein_name": "Alpha-1B adrenergic receptor", "gene_name": "Adra1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adra1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (R-MMU-390696); (R-MMU-416476); (R-MMU-416482)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21183079;21750661;22120526;25428506;34428180;7595531", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0045818 negative regulation of glycogen catabolic process;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97717-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHH7-1", "uniprot_id": [ { "id": "ADCY3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHH7", "type": "external" } ], "mass": 129085.0, "length": 1145, "protein_name": "Adenylate cyclase type 3", "gene_name": "Adcy3", "organism": "Mouse", "refseq_name": "adenylate cyclase type 3 isoform 1", "refseq_ac": [ { "id": "NP_612178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612178", "type": "external" } ], "gene_names_uniprotkb": "Adcy3", "gene_names_refseq": "AC3; ACIII; Adcy3; mKIAA0511", "protein_names_uniprotkb": "Adenylate cyclase type 3; 4.6.1.1; AC-III; AC3; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3", "protein_names_refseq": "AC-III; ATP pyrophosphate-lyase 3; adenylate cyclase type 3 isoform 1; adenylate cyclase type 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); major depressive disorder (Disease Ontology:DOID:1470); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:104111); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11055432;15705663;17924533;21183079;21750661;23077041;25329148;25908845;30084848;34428180;40472089;9768837", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:11055432, PubMed:25329148, PubMed:40472089, PubMed:9768837). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium (PubMed:11055432, PubMed:9768837). Required for the perception of odorants (PubMed:11055432). Mediates signaling cascades in primary cilia: specifically activated by G alpha protein GNAS/G(s) in primary cilia (PubMed:40472089). Plays a role in regulating food intake and body fat accumulation in the paraventricular nucleus of the hypothalamus (PVH) by acting downstream of MC4R activation (PubMed:40472089). Required for normal sperm motility and normal male fertility (PubMed:15705663)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B8JK57", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0035556 intracellular signal transduction;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VHH7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K67-1", "uniprot_id": [ { "id": "AASS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K67", "type": "external" } ], "mass": 102975.0, "length": 926, "protein_name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "gene_name": "Aass", "organism": "Mouse", "refseq_name": "alpha-aminoadipic semialdehyde synthase, mitochondrial", "refseq_ac": [ { "id": "NP_038958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038958", "type": "external" } ], "gene_names_uniprotkb": "Aass; Lorsdh", "gene_names_refseq": "Aass; LKR/SDH; LKR; LOR/SDH; LOR; Lorsdh; SDH", "protein_names_uniprotkb": "Alpha-aminoadipic semialdehyde synthase, mitochondrial; LKR/SDH", "protein_names_refseq": "alpha-aminoadipic semialdehyde synthase, mitochondrial; lysine oxoglutarate reductase; saccharopine dehydrogenase", "tax_id": 10090, "disease": "hyperlysinemia (Disease Ontology:DOID:9274)", "pathway": " (mmu:30956); (R-MMU-71064)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10567240;18936211;21750661;23576753;23806337;30084848;34428180;37453647;38552285", "class_list": "", "function": "Bifunctional enzyme that catalyzes the first two steps in lysine degradation., [UniProtKB, PubMed]; Hyperactivation of succinate dehydrogenase promotes pyroptosis of macrophage via ROS-induced GSDMD oligomerization in acute liver failure., [RefSeq, PubMed]; These results indicate AASS knockdown decreases the lysine requirement of the cell via a reduction of lysine catabolism through the saccharopine pathway., [RefSeq, PubMed]; This gene encodes a bifunctional mitochondrial protein that catalyzes the first two steps in the lysine degradation pathway. The N-terminus contains lysine-ketoglutarate reductase activity and converts lysine to saccharopine, whereas the C-terminus contains saccharopine dehydrogenase activity and converts saccharopine to alpha-aminoadipate semialdehyde. Mutations in a human gene encoding a highly similar protein are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1I9", "ec_number_list": [ { "id": "1.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.8", "type": "external" }, { "id": "1.5.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.9", "type": "external" } ], "go_molecular_function": "GO:0004753 saccharopine dehydrogenase activity;GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006554 lysine catabolic process;GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0019477 L-lysine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99K67-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88444-1", "uniprot_id": [ { "id": "ADCY1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88444", "type": "external" } ], "mass": 123373.0, "length": 1118, "protein_name": "Adenylate cyclase type 1", "gene_name": "Adcy1", "organism": "Mouse", "refseq_name": "adenylate cyclase type 1", "refseq_ac": [ { "id": "NP_033752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033752", "type": "external" } ], "gene_names_uniprotkb": "Adcy1", "gene_names_refseq": "AC1; Adcy1; D11Bwg1392e; I-AC; brl", "protein_names_uniprotkb": "Adenylate cyclase type 1; 4.6.1.1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase", "protein_names_refseq": "ATP pyrophosphate-lyase 1; Ca(2+)/calmodulin-activated adenylyl cyclase; adenylate cyclase type 1; adenylate cyclase type I; adenylyl cyclase 1; barrelless", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 44 (Disease Ontology:DOID:0110501); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:432530); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "21183079;24048828;24482543;38389098;7816821;9662407", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:7816821, PubMed:9662407). May be involved in regulatory processes in the central nervous system (PubMed:9662407). May play a role in memory and learning (PubMed:7816821). Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (PubMed:24048828)., [UniProtKB, PubMed, PubMed, PubMed]; Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SS89", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0007409 axonogenesis;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88444-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03958-1", "uniprot_id": [ { "id": "ADA_MOUSE", "url": "https://www.uniprot.org/uniprot/P03958", "type": "external" } ], "mass": 39992.0, "length": 352, "protein_name": "Adenosine deaminase", "gene_name": "Ada", "organism": "Mouse", "refseq_name": "adenosine deaminase isoform 1", "refseq_ac": [ { "id": "NP_001258981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258981", "type": "external" } ], "gene_names_uniprotkb": "Ada", "gene_names_refseq": "Ada", "protein_names_uniprotkb": "Adenosine deaminase; 3.5.4.4; Adenosine aminohydrolase", "protein_names_refseq": "adenosine aminohydrolase; adenosine deaminase isoform 1", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); trypanosomiasis (Disease Ontology:DOID:10113); Legionnaires' disease (Disease Ontology:DOID:10457); stomach cancer (Disease Ontology:DOID:10534); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); Q fever (Disease Ontology:DOID:11100); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); uterine fibroid (Disease Ontology:DOID:13223); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); pulmonary sarcoidosis (Disease Ontology:DOID:13406); sporotrichosis (Disease Ontology:DOID:14484); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); leptospirosis (Disease Ontology:DOID:2297); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); adenosine deaminase deficiency (Disease Ontology:DOID:5810); severe combined immunodeficiency (Disease Ontology:DOID:627); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); oral cavity cancer (Disease Ontology:DOID:8618); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11486); (R-MMU-74217); (R-MMU-9755088)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10720488;10899903;11435465;11471062;1925539;19892989;2387582;2410423;26038697;30641086;34428180;38823639;7670465;7731963;8634299;8672487;8783262;8942668;9272950;9622483", "class_list": "", "function": "A crucial role of adenosine deaminase in regulating gluconeogenesis in mice., [RefSeq, PubMed]; Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:10720488, PubMed:8634299, PubMed:8672487, PubMed:8942668, PubMed:9272950). Plays an important role in purine metabolism and in adenosine homeostasis (PubMed:10720488, PubMed:9272950). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (PubMed:11435465). Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (PubMed:9272950). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inhibition of eADA blocked endothelial activation suggesting a crucial role of this enzyme in the control of vascular inflammation. This supports the concept of eADA targeted vascular protection therapy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "4.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.3.-", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0001883 purine nucleoside binding;GO:0019239 deaminase activity;GO:0046936 2'-deoxyadenosine deaminase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0006154 adenosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P03958-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05202-1", "uniprot_id": [ { "id": "AATM_MOUSE", "url": "https://www.uniprot.org/uniprot/P05202", "type": "external" } ], "mass": 47411.0, "length": 430, "protein_name": "Aspartate aminotransferase, mitochondrial", "gene_name": "Got2", "organism": "Mouse", "refseq_name": "aspartate aminotransferase, mitochondrial", "refseq_ac": [ { "id": "NP_034455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034455", "type": "external" } ], "gene_names_uniprotkb": "Got2; Got-2", "gene_names_refseq": "FABP-pm; Got-2; Got2; Kyat4; mAspAT", "protein_names_uniprotkb": "Aspartate aminotransferase, mitochondrial; 2.6.1.1; 2.6.1.7; FABP-1; FABPpm; Fatty acid-binding protein; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; Transaminase A; mAspAT", "protein_names_refseq": "FABP-1; FABPpm; aspartate aminotransferase, mitochondrial; fatty acid-binding protein; glutamate oxaloacetate transaminase 2, mitochondrial; kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mitochondrial aspartate aminotransferase; plasma membrane fatty acid binding protein; plasma membrane-associated fatty acid-binding protein; transaminase A", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 82 (Disease Ontology:DOID:0080715); neurodegenerative disease (Disease Ontology:DOID:1289); acute kidney failure (Disease Ontology:DOID:3021); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14719); (R-MMU-389661); (R-MMU-8963693); (R-MMU-8964539); (R-MMU-9856872)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10642497;16800626;17442055;19826765;20977429;23576753;23806337;24129315;26740625;2828632;31219806;31422819;33300544;33725478;34428180;36288343;37453647;37507081;3782150;37828378;38646781;39927985;40684658;7878064", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids., [UniProtKB, PubMed, PubMed]; Effect of the mitochondrial transaminase (GOT2) on membrane potential-sensitive respiration in mitochondria of differentiated C2C12 muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09188;Q3TIP6;Q3UD91;Q5HZH5", "ec_number_list": [ { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" }, { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" }, { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0019899 enzyme binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0045471 response to ethanol;GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P05202-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13516-1", "uniprot_id": [ { "id": "ACOD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P13516", "type": "external" } ], "mass": 41046.0, "length": 355, "protein_name": "Acyl-CoA desaturase 1", "gene_name": "Scd1", "organism": "Mouse", "refseq_name": "acyl-CoA desaturase 1", "refseq_ac": [ { "id": "NP_033153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033153", "type": "external" } ], "gene_names_uniprotkb": "Scd1", "gene_names_refseq": "Scd-1; Scd1; Scd; ab", "protein_names_uniprotkb": "Acyl-CoA desaturase 1; 1.14.19.1; Delta(9)-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1", "protein_names_refseq": "acyl-CoA desaturase 1; asebia; delta(9)-desaturase 1; fatty acid desaturase 1; stearoyl-CoA desaturase 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hyperinsulinism (Disease Ontology:DOID:2018); carcinoma (Disease Ontology:DOID:305); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (mmu:20249); (R-MMU-75105)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10545940;10854228;10899171;11161812;11441127;11500518;11533264;12177411;12815040;15210843;15278437;16275639;16443825;17127673;17738154;21750661;24295027;24356954;26098370;2903162;30084848;34428180", "class_list": "glycogene", "function": "Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:11500518, PubMed:11533264, PubMed:16275639, PubMed:16443825, PubMed:26098370). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:11500518, PubMed:11533264, PubMed:16443825, PubMed:26098370). Plays an important role in lipid biosynthesis (PubMed:10899171, PubMed:11441127, PubMed:11500518, PubMed:11533264, PubMed:12177411, PubMed:17127673, PubMed:26098370). Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (PubMed:12177411, PubMed:17127673, PubMed:24295027, PubMed:24356954). Plays an important role in body energy homeostasis (PubMed:15210843, PubMed:17127673, PubMed:24295027, PubMed:24356954). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:10899171, PubMed:11441127, PubMed:11500518, PubMed:11533264, PubMed:12177411, PubMed:15210843, PubMed:26098370). Required for normal development of sebaceous glands (PubMed:11533264, PubMed:17738154). Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland (PubMed:11500518). Required for normal production of meibum, an oily material that prevents drying of the cornea (PubMed:11533264)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922I6", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0046872 metal ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016491 oxidoreductase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0006641 triglyceride metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P13516-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51881-1", "uniprot_id": [ { "id": "ADT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P51881", "type": "external" } ], "mass": 32931.0, "length": 298, "protein_name": "ADP/ATP translocase 2", "gene_name": "Slc25a5", "organism": "Mouse", "refseq_name": "ADP/ATP translocase 2", "refseq_ac": [ { "id": "NP_031477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031477", "type": "external" } ], "gene_names_uniprotkb": "Slc25a5; Aac2; Ant2", "gene_names_refseq": "Ant2; Slc25a5", "protein_names_uniprotkb": "ADP/ATP translocase 2; ADP,ATP carrier protein 2; ANT 2; Adenine nucleotide translocator 2; Solute carrier family 25 member 5", "protein_names_refseq": "ADP, ATP carrier protein 2; ADP/ATP translocase 2; adenine nucleotide translocase; adenine nucleotide translocator 2, fibroblast", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); epilepsy (Disease Ontology:DOID:1826); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:11740); (R-MMU-83936); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10974536;14749836;18034455;21540332;22645316;23576753;23806337;24788674;25605945;25613378;26740625;31341297;31489369;31618756;32152506;33300544;33725478;34428180;35820727;36210013;36288343;37453647;37507081;39627609;39927985;8903724", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:31341297). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31341297, PubMed:31489369). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:31341297). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (PubMed:31341297). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:31341297). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (PubMed:31341297). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31489369). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (PubMed:31489369). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (PubMed:31618756). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61311", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0005471 ATP:ADP antiporter activity;GO:0015078 proton transmembrane transporter activity;GO:0000295 adenine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0042645 mitochondrial nucleoid;GO:0043209 myelin sheath", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0007059 chromosome segregation;GO:0008284 positive regulation of cell population proliferation;GO:0030218 erythrocyte differentiation;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P51881-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56485-1", "uniprot_id": [ { "id": "ACKR3_MOUSE", "url": "https://www.uniprot.org/uniprot/P56485", "type": "external" } ], "mass": 41636.0, "length": 362, "protein_name": "Atypical chemokine receptor 3", "gene_name": "Ackr3", "organism": "Mouse", "refseq_name": "atypical chemokine receptor 3", "refseq_ac": [ { "id": "NP_001258536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258536", "type": "external" } ], "gene_names_uniprotkb": "Ackr3; Cmkor1; Cxcr7; Rdc1", "gene_names_refseq": "Ackr3; CXC-R7; CXCR-7; Cmkor1; Cxcr7; RDC-1; Rdc1", "protein_names_uniprotkb": "Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G protein-coupled receptor RDC1 homolog; RDC-1", "protein_names_refseq": "C-X-C chemokine receptor type 7; G-protein coupled receptor RDC1 homolog; atypical chemokine receptor 3; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1", "tax_id": 10090, "disease": "laryngeal carcinoma (Disease Ontology:DOID:2600); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:12778); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16940167;17804806;18442043;20161793;20681075;21183079;21220100;21246655;31211835;39253784;9510554", "class_list": "", "function": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835). Acts as a receptor for SHLP2, mediating its effects on activation of proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus which leads to suppression of food intake and increased energy expenditure (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve., [RefSeq, PubMed]; Disfrupted cardiac development but normal hematopoiesis in mice deficient in Cxcr7., [RefSeq, PubMed]; Seems to play an unimportant role in bone; however, an important role is indicated for CXCR7 in the cardiovascular system during embryonic and early postnatal development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91WI0", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0015026 coreceptor activity;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P56485-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84309-1", "uniprot_id": [ { "id": "ADCY5_MOUSE", "url": "https://www.uniprot.org/uniprot/P84309", "type": "external" } ], "mass": 139122.0, "length": 1262, "protein_name": "Adenylate cyclase type 5", "gene_name": "Adcy5", "organism": "Mouse", "refseq_name": "adenylate cyclase type 5 isoform 1", "refseq_ac": [ { "id": "NP_001012783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012783", "type": "external" } ], "gene_names_uniprotkb": "Adcy5", "gene_names_refseq": "Ac5; Adcy5", "protein_names_uniprotkb": "Adenylate cyclase type 5; 4.6.1.1; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5", "protein_names_refseq": "ATP pyrophosphate-lyase 5; adenylate cyclase type 5 isoform 1; adenylate cyclase type 5; adenylate cyclase type V; adenylyl cyclase 5", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:224129); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-400042); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17114649;20173027;21183079;21670265;24129315;33300544;33919448;34428180;36539102;39413138", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion., [UniProtKB, UniProtKB]; Early-life low-level lead exposure alters anxiety-like behavior, voluntary alcohol consumption and AC5 protein content in adult male and female C57BL/6 J mice., [RefSeq, PubMed]; Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue. Publication Status: Online-Only, [RefSeq, PubMed]; KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU67;Q3UH09;Q5BL06", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008179 adenylate cyclase binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007626 locomotory behavior;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P84309-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97490-1", "uniprot_id": [ { "id": "ADCY8_MOUSE", "url": "https://www.uniprot.org/uniprot/P97490", "type": "external" } ], "mass": 140095.0, "length": 1249, "protein_name": "Adenylate cyclase type 8", "gene_name": "Adcy8", "organism": "Mouse", "refseq_name": "adenylate cyclase type 8 isoform 1", "refseq_ac": [ { "id": "NP_033753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033753", "type": "external" } ], "gene_names_uniprotkb": "Adcy8", "gene_names_refseq": "AC8; Adcy8", "protein_names_uniprotkb": "Adenylate cyclase type 8; 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase", "protein_names_refseq": "ATP pyrophosphate-lyase 8; adenylate cyclase type 8 isoform 1; adenylate cyclase type 8; adenylate cyclase type VIII; adenylyl cyclase 8; ca(2+)/calmodulin-activated adenylyl cyclase", "tax_id": 10090, "disease": "", "pathway": " (mmu:11514); (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10482244;10864938;12441059;14585998;17335981;18222416;18448650;19158400;20638449;21183079;21750661;24129315;25403481;27234425;37737772", "class_list": "", "function": "Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB]; Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9768, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G3X8V9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004016 adenylate cyclase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007613 memory;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P97490-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14BT6-1", "uniprot_id": [ { "id": "A4GCT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14BT6", "type": "external" } ], "mass": 39276.0, "length": 341, "protein_name": "Alpha-1,4-N-acetylglucosaminyltransferase", "gene_name": "A4gnt", "organism": "Mouse", "refseq_name": "alpha-1,4-N-acetylglucosaminyltransferase", "refseq_ac": [ { "id": "NP_001070892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070892", "type": "external" } ], "gene_names_uniprotkb": "A4gnt", "gene_names_refseq": "A4gnt; Alpha4gnt; Gm798", "protein_names_uniprotkb": "Alpha-1,4-N-acetylglucosaminyltransferase; 2.4.1.-; Alpha4GnT", "protein_names_refseq": "alpha-1,4-N-acetylglucosaminyltransferase", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:333424); (R-MMU-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10430883;19751437;22307328", "class_list": "glycogene;glycosyltransferase", "function": "A4gnt(-/-) mice show complete lack of alphaGlcNAc expression in gastric gland mucin, [RefSeq, PubMed]; Catalyzes the transfer of N-acetylglucosamine (GlcNAc) residues from UDP-N-acetyl-alpha-D-glucosamine donnors to beta (1->4)-linked or beta-(1->3)-linked galactose residues on O-glycans like core 2 branched O-glycans (PubMed:22307328). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (By similarity). May protect against inflammation-associated gastric adenocarcinoma (PubMed:22307328)., [UniProtKB, PubMed, UniProtKB]; This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]., [RefSeq]; This publication contains functional information for the human homolog of mouse A4gnt., [RefSeq, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 94, "hit_score": 0.4, "record_id": "Q14BT6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640N1-1", "uniprot_id": [ { "id": "AEBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640N1", "type": "external" } ], "mass": 128365.0, "length": 1128, "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "Aebp1", "organism": "Mouse", "refseq_name": "adipocyte enhancer-binding protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001278786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278786", "type": "external" } ], "gene_names_uniprotkb": "Aebp1; Aclp", "gene_names_refseq": "ACLP; Aebp1", "protein_names_uniprotkb": "Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein", "protein_names_refseq": "adipocyte enhancer-binding protein 1 isoform 1 precursor; adipocyte enhancer-binding protein 1; aortic carboxypeptidase-like protein", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome classic-like 2 (Disease Ontology:DOID:0080732)", "pathway": " (mmu:11568)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10406805;11152475;11438679;11738825;12072377;14729459;15654748;15749083;15927179;16307171;16461908;16538615;17202411;17299101;22872234;25428506;31219806;34203471;34428180;36210013;37024441;37828378;39358837;7477299;8920928;9624159", "class_list": "", "function": "AEBP1 Contributes to Breast Cancer Progression by Facilitating Cell Proliferation, Migration, Invasion, and Blocking Apoptosis., [RefSeq, PubMed]; AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling., [RefSeq, PubMed]; As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix., [UniProtKB, UniProtKB]; May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O88442;Q3TVV5;Q3TWA7;Q3TX56;Q3TXB2;Q5NCI9;Q61281", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0005518 collagen binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006355 regulation of DNA-templated transcription;GO:1904026 regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q640N1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZX8-1", "uniprot_id": [ { "id": "ABLM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZX8", "type": "external" } ], "mass": 77630.0, "length": 682, "protein_name": "Actin-binding LIM protein 3", "gene_name": "Ablim3", "organism": "Mouse", "refseq_name": "actin-binding LIM protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001157963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963", "type": "external" } ], "gene_names_uniprotkb": "Ablim3; Kiaa0843", "gene_names_refseq": "Ablim3; D930036B08Rik", "protein_names_uniprotkb": "Actin-binding LIM protein 3; Actin-binding LIM protein family member 3; abLIM-3", "protein_names_refseq": "abLIM-3; actin-binding LIM protein 3 isoform 1; actin-binding LIM protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:319713)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;16452087;17194709;17242355;19458039;21183079;22517741;22645316;24129315;30084848;32848054;34428180;34678516;35822049;36757814;40021952;40885482", "class_list": "", "function": "ABLIM-2 and -3 associate with STARS and directly bind F-actin, [RefSeq, PubMed]; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q52KR1;Q6PAI7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0045202 synapse", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0060271 cilium assembly;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q69ZX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPZ8-1", "uniprot_id": [ { "id": "ABRX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPZ8", "type": "external" } ], "mass": 46039.0, "length": 407, "protein_name": "BRCA1-A complex subunit Abraxas 1", "gene_name": "Abraxas1", "organism": "Mouse", "refseq_name": "BRCA1-A complex subunit Abraxas 1", "refseq_ac": [ { "id": "NP_765993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765993", "type": "external" } ], "gene_names_uniprotkb": "Abraxas1; Abra1; Ccdc98; Fam175a", "gene_names_refseq": "3830405G04Rik; 5630400M01Rik; Abraxas1; Ccdc98; Fam175a", "protein_names_uniprotkb": "BRCA1-A complex subunit Abraxas 1; Coiled-coil domain-containing protein 98; Protein FAM175A", "protein_names_refseq": "BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; family with sequence similarity 175, member A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70681); (R-MMU-5689901); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "21183079;21750661;29497033", "class_list": "", "function": "Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX., [UniProtKB, UniProtKB]; Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ88;Q8BFV6;Q8BT69;Q8K2T7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0090307 mitotic spindle assembly;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BPZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Y0-1", "uniprot_id": [ { "id": "ABHD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Y0", "type": "external" } ], "mass": 38205.0, "length": 336, "protein_name": "Monoacylglycerol lipase ABHD6", "gene_name": "Abhd6", "organism": "Mouse", "refseq_name": "monoacylglycerol lipase ABHD6 isoform 1", "refseq_ac": [ { "id": "NP_001317993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317993", "type": "external" } ], "gene_names_uniprotkb": "Abhd6", "gene_names_refseq": "0610041D24Rik; Abhd6", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; 3.1.1.23; Abhydrolase domain-containing protein 6", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; monoacylglycerol lipase ABHD6 isoform 1; monoacylglycerol lipase ABHD6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66082); (R-MMU-426048)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18096503;20657592;21665953;23806692;24095738;26491015;36990366;37838014;38159878", "class_list": "", "function": "ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility., [RefSeq, PubMed]; ABHD6 is a rate-limiting step of 2-AG signaling, [RefSeq, PubMed]; ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice., [RefSeq, PubMed]; Data reveal that 85% of brain 2-arachidonoylglycerol hydrolase activity can be ascribed to monoacylglycerol lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and ABHD12., [RefSeq, PubMed]; Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons., [RefSeq, PubMed]; FAAH but not monoacyl glycerol lipase exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage., [RefSeq, PubMed]; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:18096503, PubMed:20657592). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (PubMed:18096503, PubMed:20657592). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (PubMed:24095738). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGD2;Q9DCD4", "ec_number_list": [ { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:2001311 lysobisphosphatidic acid metabolic process;GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0009395 phospholipid catabolic process;GO:0030336 negative regulation of cell migration;GO:0046464 acylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R2Y0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5A3-1", "uniprot_id": [ { "id": "AB1IP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5A3", "type": "external" } ], "mass": 74319.0, "length": 670, "protein_name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "gene_name": "Apbb1ip", "organism": "Mouse", "refseq_name": "amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "refseq_ac": [ { "id": "NP_062329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062329", "type": "external" } ], "gene_names_uniprotkb": "Apbb1ip; Prel1", "gene_names_refseq": "9930118P07Rik; Apbb1ip; Prp48", "protein_names_uniprotkb": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1; PREL-1; Proline-rich EVH1 ligand 1; Proline-rich protein 48", "protein_names_refseq": "APBB1-interacting protein 1; PREL-1; amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; amyloid beta A4 precursor protein-binding family B member 1-interacting protein; proline-rich EVH1 ligand 1; proline-rich protein 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:54519); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-5674135)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "15642358;16075062;19144319;20404115;21183079;25428506;26495903;30084848;30779550;34428180;9407065", "class_list": "", "function": "Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity)., [UniProtKB]; Data demonstrate a novel mechanism by which alphavbeta3 integrin acts to locally suppress beta1 integrin activation and regulate VASP and RIAM to control cell adhesion and migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35329;Q8BRU0;Q99KV8", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030027 lamellipodium", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0035556 intracellular signal transduction;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R5A3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V92-1", "uniprot_id": [ { "id": "ACLY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V92", "type": "external" } ], "mass": 119728.0, "length": 1091, "protein_name": "ATP-citrate synthase", "gene_name": "Acly", "organism": "Mouse", "refseq_name": "ATP-citrate synthase isoform 2", "refseq_ac": [ { "id": "NP_598798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598798", "type": "external" } ], "gene_names_uniprotkb": "Acly", "gene_names_refseq": "A730098H14Rik; Acly", "protein_names_uniprotkb": "ATP-citrate synthase; 2.3.3.8; ATP-citrate (pro-S-)-lyase; Citrate cleavage enzyme", "protein_names_refseq": "ATP-citrate (pro-S-)-lyase; ATP-citrate synthase isoform 2; ATP-citrate synthase; citrate cleavage enzyme", "tax_id": 10090, "disease": "", "pathway": " (mmu:104112); (R-MMU-6798695); (R-MMU-75105)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "11471062;16139798;16479539;17947660;18034455;19131326;19224205;20173027;21183079;22645316;23806337;25153642;25428506;25450640;25605945;30084848;30779550;31219806;31675964;31996678;33300544;33397994;33725478;34203471;34428180;34491895;34887587;35820727;37453647;39627609", "class_list": "", "function": "Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": 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"url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", 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"3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": 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"5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003878 ATP citrate synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0036064 ciliary basal body;GO:0097228 sperm principal piece", "go_biological_process": "GO:0006101 citrate metabolic process;GO:0008610 lipid biosynthetic process;GO:0006084 acetyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q91V92-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LH9-1", "uniprot_id": [ { "id": "3BP5L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LH9", "type": "external" } ], "mass": 43374.0, "length": 392, "protein_name": "SH3 domain-binding protein 5-like", "gene_name": "Sh3bp5l", "organism": "Mouse", "refseq_name": "SH3 domain-binding protein 5-like isoform 1", "refseq_ac": [ { "id": "NP_001154810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154810", "type": "external" } ], "gene_names_uniprotkb": "Sh3bp5l; Kiaa1720", "gene_names_refseq": "2310074E09Rik; Sh3bp5l; mKIAA1720", "protein_names_uniprotkb": "SH3 domain-binding protein 5-like; SH3BP-5-like", "protein_names_refseq": "SH3 domain-binding protein 5-like isoform 1; SH3 domain-binding protein 5-like; SH3BP-5-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:79566)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;31219806;34203471;34428180", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor (GEF) for RAB11A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMF7;Q8BUC2;Q91YX6", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99LH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D020-3", "uniprot_id": [ { "id": "5NT3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D020", "type": "external" } ], "mass": 37252.0, "length": 331, "protein_name": "Cytosolic 5'-nucleotidase 3A", "gene_name": "Nt5c3a", "organism": "Mouse", "refseq_name": "cytosolic 5'-nucleotidase 3A isoform 2", "refseq_ac": [ { "id": "NP_001239303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239303", "type": "external" } ], "gene_names_uniprotkb": "Nt5c3a; Nt5c3", "gene_names_refseq": "1600024P05Rik; 2610206B05Rik; 3110004A18Rik; Nt5c3a; Nt5c3; Nt5y; P5'N-1; P5N-1; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1; cN-III; lupin; p36", "protein_names_uniprotkb": "Cytosolic 5'-nucleotidase 3A; 3.1.3.5; 3.1.3.91; 7-methylguanosine nucleotidase; 7-methylguanosine phosphate-specific 5'-nucleotidase; Cytosolic 5'-nucleotidase 3; Cytosolic 5'-nucleotidase III; Lupin; P5'N-1; P5N-1; PN-I; Pyrimidine 5'-nucleotidase 1; cN-III", "protein_names_refseq": "5'-nucleotidase, pyrimidine; 7-methylguanosine nucleotidase; 7-methylguanosine phosphate-specific 5'-nucleotidase; cytosolic 5'-nucleotidase 3A isoform 2; cytosolic 5'-nucleotidase 3A; cytosolic 5'-nucleotidase 3; cytosolic 5'-nucleotidase III; pyrimidine 5'-nucleotidase 1; uridine monophosphatase 1", "tax_id": 10090, "disease": "congenital nonspherocytic hemolytic anemia 8 (Disease Ontology:DOID:0051007)", "pathway": " (mmu:107569); (R-MMU-73621)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11180800;16672222;19224205;20173027;20484733;21183079;22925580;25428506;30084848;30779550;34428180;35820727;37507081;37828378", "class_list": "", "function": "Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate., [UniProtKB, UniProtKB]; Report describes the first X-ray structure of a catalytically inactivated variant of murine cN-III with a natural substrate, uridine 5'-monophosphate, in the active site at 1.74A resolution, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI05;Q9D0D9", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0046085 adenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D020-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERZ4-1", "uniprot_id": [ { "id": "ACM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERZ4", "type": "external" } ], "mass": 51499.0, "length": 466, "protein_name": "Muscarinic acetylcholine receptor M2", "gene_name": "Chrm2", "organism": "Mouse", "refseq_name": "muscarinic acetylcholine receptor M2", "refseq_ac": [ { "id": "NP_987076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_987076", "type": "external" } ], "gene_names_uniprotkb": "Chrm2; Chrm-2", "gene_names_refseq": "AChR-M2; Chrm-2; Chrm2; M2", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M2", "protein_names_refseq": "AChR M2; muscarinic acetylcholine receptor 2; muscarinic acetylcholine receptor M2", "tax_id": 10090, "disease": "Chagas disease (Disease Ontology:DOID:12140); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:243764); (R-MMU-390648); (R-MMU-418594); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "18299400;21183079;30084848", "class_list": "", "function": "Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9Q9P0", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERZ4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHI2-1", "uniprot_id": [ { "id": "ADAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHI2", "type": "external" } ], "mass": 55355.0, "length": 499, "protein_name": "tRNA-specific adenosine deaminase 1", "gene_name": "Adat1", "organism": "Mouse", "refseq_name": "tRNA-specific adenosine deaminase 1 isoform 1", "refseq_ac": [ { "id": "NP_038953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038953", "type": "external" } ], "gene_names_uniprotkb": "Adat1", "gene_names_refseq": "Adat1; MMADAT1", "protein_names_uniprotkb": "tRNA-specific adenosine deaminase 1; 3.5.4.34; mADAT1; tRNA-specific adenosine-37 deaminase", "protein_names_refseq": "tRNA-specific adenosine deaminase 1 isoform 1; tRNA-specific adenosine deaminase 1; tRNA-specific adenosine-37 deaminase", "tax_id": 10090, "disease": "", "pathway": " (mmu:30947)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10675613;17242355;21183079;21750661;31219806", "class_list": "", "function": "Specifically deaminates adenosine-37 to inosine in tRNA-Ala., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU04;Q8CBP0;Q8VE23", "ec_number_list": [ { "id": "3.5.4.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.34", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0043829 tRNA-specific adenosine-37 deaminase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI39-1", "uniprot_id": [ { "id": "ABCBA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI39", "type": "external" } ], "mass": 77188.0, "length": 715, "protein_name": "ATP-binding cassette sub-family B member 10, mitochondrial", "gene_name": "Abcb10", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family B member 10, mitochondrial precursor", "refseq_ac": [ { "id": "NP_062425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062425", "type": "external" } ], "gene_names_uniprotkb": "Abcb10", "gene_names_refseq": "Abc-me; Abcb10; Abcb12", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 10, mitochondrial; 7.6.2.-; ABC transporter 10 protein; ABC-me protein; ABC-mitochondrial erythroid protein; ATP-binding cassette transporter 10", "protein_names_refseq": "ABC-mitochondrial erythroid protein; ATP-binding cassette sub-family B member 10, mitochondrial precursor; ATP-binding cassette sub-family B member 10, mitochondrial; ATP-binding cassette transporter 10; ATP-binding cassette, sub-family B (MDR/TAP), member 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:56199)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10835348;15215243;19805291;20427704;22240895;24421385;25428506;26053025;28808058;30084848;30765471;34011630;34428180;34823065;34893527;37269954;38655715", "class_list": "", "function": "ABCB10 Loss Reduces CD4(+) T Cell Activation and Memory Formation., [RefSeq, PubMed]; ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22240895, PubMed:24421385, PubMed:26053025, PubMed:28808058, PubMed:34011630). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:24421385, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (PubMed:19805291). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis., [RefSeq, PubMed]; Data show that the binding domain of Mfrn1-Abcb10 interaction maps to the N terminus of Mfrn1., [RefSeq, PubMed]; Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance., [RefSeq, PubMed]; Ferrochelatase forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis., [RefSeq, PubMed]; Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4., [RefSeq, PubMed]; This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542P7;Q9D0C7", "ec_number_list": [ { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0045648 positive regulation of erythrocyte differentiation;GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0048821 erythrocyte development;GO:0006783 heme biosynthetic process;GO:0090374 oligopeptide export from mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9JI39-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVM8-1", "uniprot_id": [ { "id": "AADAT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVM8", "type": "external" } ], "mass": 47598.0, "length": 425, "protein_name": "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial", "gene_name": "Aadat", "organism": "Mouse", "refseq_name": "kynurenine/alpha-aminoadipate aminotransferase, mitochondrial", "refseq_ac": [ { "id": "NP_035964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035964", "type": "external" } ], "gene_names_uniprotkb": "Aadat; Kat2", "gene_names_refseq": "Aadat; Aadt; KATII; Kat2; Kyat2; mKat-2", "protein_names_uniprotkb": "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; 2.6.1.39; 2.6.1.4; 2.6.1.63; 2.6.1.73; 2.6.1.7; AadAT; Alpha-aminoadipate aminotransferase; Glycine transaminase AADAT; KAT/AadAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT", "protein_names_refseq": "2-aminoadipate aminotransferase; 2-aminoadipate transaminase; KAT/AadAT; alpha-aminoadipate aminotransferase; glycine transaminase AADAT; kynurenine aminotransferase II; kynurenine--glyoxylate transaminase AADAT; kynurenine--oxoglutarate aminotransferase II; kynurenine--oxoglutarate transaminase 2; kynurenine--oxoglutarate transaminase II; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; methionine--glyoxylate transaminase AADAT", "tax_id": 10090, "disease": "", "pathway": " (mmu:23923); (R-MMU-71064); (R-MMU-71240)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10441733;15140935;15282294;21183079;23576753;23806337;30084848;32768617;33238153;34428180", "class_list": "", "function": "Alpha7* nAChR and NMDA receptor functions were studied in kynurenine aminotransferase II null mice(mKat-2-/- mice). At 21 postnatal days, mKat-2-/- mice had lower hippocampal kynurenic acid levels and more spontaneous locomotor activity than control mice, [RefSeq, PubMed]; N-Acetylcysteine Inhibits Kynurenine Aminotransferase II., [RefSeq, PubMed]; Results show that gene targeting of kynurenine aminotransferase II (KAT) in mice leads to early and transitory decreases in brain KAT activity and kynurenic acid levels with commensurate behavioral and neuropathological changes., [RefSeq, PubMed]; Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum., [RefSeq, PubMed]; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" }, { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" } ], "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0047536 2-aminoadipate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006536 glutamate metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0070189 kynurenine metabolic process;GO:1901605 alpha-amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z103-1", "uniprot_id": [ { "id": "ADNP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z103", "type": "external" } ], "mass": 124308.0, "length": 1108, "protein_name": "Activity-dependent neuroprotector homeobox protein", "gene_name": "Adnp", "organism": "Mouse", "refseq_name": "activity-dependent neuroprotector homeobox protein isoform 1", "refseq_ac": [ { "id": "NP_001297015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297015", "type": "external" } ], "gene_names_uniprotkb": "Adnp", "gene_names_refseq": "Adnp; mKIAA0784", "protein_names_uniprotkb": "Activity-dependent neuroprotector homeobox protein; Activity-dependent neuroprotective protein", "protein_names_refseq": "activity-dependent neuroprotector homeobox protein isoform 1; activity-dependent neuroprotector homeobox protein", "tax_id": 10090, "disease": "Helsmoortel-Van Der Aa Syndrome (Disease Ontology:DOID:0070058); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:11538); (R-MMU-9940465)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10037502;12888219;17242355;21183079;23071114;24129315;31219806;32533114;34428180;34887587;35820727;36852467;37365244;38479840;39627609;40021952", "class_list": "", "function": "ADNP is identified as a new key gene essential for organogenesis in the developing embryo and may be implicated as a clinical target associated with proper neurodevelopment., [RefSeq, PubMed]; ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Adnp-mutant mice with cognitive inflexibility, CaMKIIalpha hyperactivity, and synaptic plasticity deficits. Erratum:[Mol Psychiatry. 2023 Aug;28(8):3563. doi: 10.1038/s41380-023-02192-y. PMID: 37479786], [RefSeq, PubMed]; May be involved in transcriptional regulation (PubMed:23071114, PubMed:32533114). May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1 (PubMed:32533114). May be required for neural induction and neuronal differentiation (PubMed:32533114). May be involved in erythroid differentiation (PubMed:23071114)., [UniProtKB, PubMed, PubMed]; This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2BDX0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0007614 short-term memory", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9Z103-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z131-1", "uniprot_id": [ { "id": "3BP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z131", "type": "external" } ], "mass": 51807.0, "length": 463, "protein_name": "SH3 domain-binding protein 5", "gene_name": "Sh3bp5", "organism": "Mouse", "refseq_name": "SH3 domain-binding protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001334514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334514", "type": "external" } ], "gene_names_uniprotkb": "Sh3bp5; Sab", "gene_names_refseq": "SH3BP-5; Sab; Sh3bp5", "protein_names_uniprotkb": "SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; SH3BP-5", "protein_names_refseq": "SH3 domain-binding protein 5 isoform 2; SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK", "tax_id": 10090, "disease": "", "pathway": " (mmu:24056)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10339589;17242355;21183079;21844199;26506309;31219806;31487267;34331779;34428180", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (By similarity). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death., [UniProtKB, PubMed, UniProtKB]; Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis., [RefSeq, PubMed]; JNK-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice, [RefSeq, PubMed]; SAB expression levels determine the severity of JNK1-dependent liver injury, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTD6;Q8C903;Q8VCZ0", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030659 cytoplasmic vesicle membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z131-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE42-1", "uniprot_id": [ { "id": "ANR49_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE42", "type": "external" } ], "mass": 27111.0, "length": 238, "protein_name": "Ankyrin repeat domain-containing protein 49", "gene_name": "Ankrd49", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 49", "refseq_ac": [ { "id": "NP_001335189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335189", "type": "external" } ], "gene_names_uniprotkb": "Ankrd49; Fgif; Gbif", "gene_names_refseq": "Ankrd49; Gbif", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 49; Fetal globin-increasing factor; Fetal globin-inducing factor", "protein_names_refseq": "ankyrin repeat domain-containing protein 49; fetal globin inducing factor; fetal globin-increasing factor; globin inducing factor, fetal", "tax_id": 10090, "disease": "", "pathway": " (mmu:56503)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11162141;21750661;26043108;35775112", "class_list": "", "function": "ANKRD49 plays an important role in spermatogenesis via promotion of autophagy-dependent survival. Publication Status: Online-Only, [RefSeq, PubMed]; ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway. Erratum:[J Cell Mol Med. 2022 Oct;26(19):5099. doi: 10.1111/jcmm.17537. PMID: 36214284], [RefSeq, PubMed]; May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2S1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VE42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BK64-1", "uniprot_id": [ { "id": "AHSA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BK64", "type": "external" } ], "mass": 38117.0, "length": 338, "protein_name": "Activator of 90 kDa heat shock protein ATPase homolog 1", "gene_name": "Ahsa1", "organism": "Mouse", "refseq_name": "activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_666148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666148", "type": "external" } ], "gene_names_uniprotkb": "Ahsa1", "gene_names_refseq": "Ahsa1; p38", "protein_names_uniprotkb": "Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1", "protein_names_refseq": "AHA1, activator of heat shock 90kDa protein ATPase homolog 1; AHA1, activator of heat shock protein ATPase homolog 1; activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1; activator of 90 kDa heat shock protein ATPase homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217737)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "21750661;22022502;22727666;25153642;26495903;28135057;28528544;29127155;30084848;33300544;34428180;35820727;37507081", "class_list": "", "function": "Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155)., [UniProtKB, UniProtKB, PubMed]; Hsp90 phosphorylation on tyrosine313 promotes recruitment of AHA1, which stimulates Hsp90 ATPase activity, furthering the chaperoning process., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3E6", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity;GO:0051879 Hsp90 protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0032781 positive regulation of ATP-dependent activity;GO:0036506 maintenance of unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BK64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZQ7-1", "uniprot_id": [ { "id": "ANC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZQ7", "type": "external" } ], "mass": 95307.0, "length": 837, "protein_name": "Anaphase-promoting complex subunit 2", "gene_name": "Anapc2", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 2", "refseq_ac": [ { "id": "NP_780509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780509", "type": "external" } ], "gene_names_uniprotkb": "Anapc2", "gene_names_refseq": "9230107K09Rik; Anapc2; Apc2; Emi4; Imi4; mKIAA1406", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 2; APC2; Cyclosome subunit 2", "protein_names_refseq": "anaphase-promoting complex subunit 2; cyclosome subunit 2; expressed during mesenchymal induction 4; induced during mesenchymal induction 4", "tax_id": 10090, "disease": "aplastic anemia (Disease Ontology:DOID:12449); primary angle-closure glaucoma (Disease Ontology:DOID:1405); lung adenocarcinoma (Disease Ontology:DOID:3910); lung adenoma (Disease Ontology:DOID:5386); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:99152); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 9, "publication_id_list": "17947660;19900895;20173027;21183079;21750661;24804778;32687671;34428180;39627609", "class_list": "", "function": "APC2(CDH1) negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7., [RefSeq, PubMed]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (PubMed:19900895). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (PubMed:19900895)., [UniProtKB, UniProtKB, PubMed]; The regulation of Mdm2 by the E3 ubiquitin ligase APC/C is shown. It has important therapeutic implications for tumors with Mdm2 overexpression., [RefSeq, PubMed]; This gene encodes a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by ubiquitinating its specific substrates, such as mitotic cyclins and anaphase inhibitor, for subsequent degradation by the proteasome. [provided by RefSeq, Oct 2009]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCK5;Q8R2Q1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0007399 nervous system development;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BZQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54826-1", "uniprot_id": [ { "id": "AF10_MOUSE", "url": "https://www.uniprot.org/uniprot/O54826", "type": "external" } ], "mass": 113029.0, "length": 1068, "protein_name": "Protein AF-10", "gene_name": "Mllt10", "organism": "Mouse", "refseq_name": "protein AF-10 isoform 1", "refseq_ac": [ { "id": "NP_001239489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239489", "type": "external" } ], "gene_names_uniprotkb": "Mllt10; Af10", "gene_names_refseq": "Af10; B130021D15Rik; D630001B22Rik; Mllt10; mKIAA4140", "protein_names_uniprotkb": "Protein AF-10", "protein_names_refseq": "myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); protein AF-10 isoform 1; protein AF-10; translocated to, 10", "tax_id": 10090, "disease": "acute monocytic leukemia (Disease Ontology:DOID:8864); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:17354)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "20173027;21103407;21183079;21681188;21750661;29237092;30102091;31219806;34226546;36852467;37082953;40997131;9878787", "class_list": "", "function": "Conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis Erratum:[PLoS Biol. 2017 Feb 7;15(2):e1002596. doi: 10.1371/journal.pbio.1002596. PMID: 28170393] Publication Status: Online-Only, [RefSeq, PubMed]; Further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains, [RefSeq, PubMed]; In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT., [RefSeq, PubMed]; Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity). In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (By similarity)., [UniProtKB, UniProtKB]; The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis., [RefSeq, PubMed]; The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS43", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0031491 nucleosome binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O54826-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3W7-1", "uniprot_id": [ { "id": "AGR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3W7", "type": "external" } ], "mass": 19081.0, "length": 165, "protein_name": "Anterior gradient protein 3", "gene_name": "Agr3", "organism": "Mouse", "refseq_name": "anterior gradient protein 3 precursor", "refseq_ac": [ { "id": "NP_997414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997414", "type": "external" } ], "gene_names_uniprotkb": "Agr3", "gene_names_refseq": "Agr3; BCMP11; E030025L21Rik; Gm888", "protein_names_uniprotkb": "Anterior gradient protein 3", "protein_names_refseq": "anterior gradient homolog 3; anterior gradient protein 3 homolog; anterior gradient protein 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:403205)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25751668", "class_list": "", "function": "Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7NSI1;Q8BW95", "ec_number_list": [], "go_molecular_function": "GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R3W7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47739-1", "uniprot_id": [ { "id": "AL3A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P47739", "type": "external" } ], "mass": 50481.0, "length": 453, "protein_name": "Aldehyde dehydrogenase, dimeric NADP-preferring", "gene_name": "Aldh3a1", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase, dimeric NADP-preferring isoform 1", "refseq_ac": [ { "id": "NP_001106196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106196", "type": "external" } ], "gene_names_uniprotkb": "Aldh3a1; Ahd-4; Ahd4; Aldh3; Aldh4", "gene_names_refseq": "Ahd-4; Ahd4; Aldh3a1; Aldh3; Aldh", "protein_names_uniprotkb": "Aldehyde dehydrogenase, dimeric NADP-preferring; 1.2.1.5; Aldehyde dehydrogenase 4; Aldehyde dehydrogenase family 3 member A1; Dioxin-inducible aldehyde dehydrogenase 3", "protein_names_refseq": "alcohol dehydrogenase family 3, subfamily A1; aldehyde dehydrogenase 3, stomach cytosolic (class 3); aldehyde dehydrogenase 4; aldehyde dehydrogenase family 3 member A1; aldehyde dehydrogenase, dimeric NADP-preferring isoform 1; aldehyde dehydrogenase, dimeric NADP-preferring; dioxin-inducible aldehyde dehydrogenase 3", "tax_id": 10090, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); arteriosclerosis (Disease Ontology:DOID:2349)", "pathway": " (mmu:11670); (R-MMU-211945)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10376761;11784860;21750661;25286108;32493941;34428180;8148869", "class_list": "", "function": "ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:25286108). Preferentially oxidizes aromatic aldehyde substrates (PubMed:11784860). Comprises about 50 percent of corneal epithelial soluble proteins (PubMed:11784860). May play a role in preventing corneal damage caused by ultraviolet light (PubMed:10376761)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATI7;Q9R203", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0006081 aldehyde metabolic process;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47739-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RUJ5-1", "uniprot_id": [ { "id": "APBA1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RUJ5", "type": "external" } ], "mass": 92909.0, "length": 842, "protein_name": "Amyloid-beta A4 precursor protein-binding family A member 1", "gene_name": "Apba1", "organism": "Mouse", "refseq_name": "amyloid-beta A4 precursor protein-binding family A member 1", "refseq_ac": [ { "id": "NP_796008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796008", "type": "external" } ], "gene_names_uniprotkb": "Apba1; Mint1; X11; mLin-10", "gene_names_refseq": "6430513E09Rik; Apba1; Lin-10; Mint1; Mint; Urop11; X11alpha; X11", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family A member 1; Adapter protein X11alpha; Mint-1; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1", "protein_names_refseq": "UROP11-110; adapter protein X11alpha; amyloid beta (A4) precursor protein binding, family A, member 1; amyloid-beta A4 precursor protein-binding family A member 1; mint-1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319924); (R-MMU-212676)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10846156;21183079;21445306;23737971;30084848;30411795;32348748;34428180;37499733;40684658", "class_list": "", "function": "Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156)., [UniProtKB, PubMed]; Structural Basis for the High-Affinity Interaction between CASK and Mint1., [RefSeq, PubMed]; Tight control of the APP-Mint1 interaction in regulating amyloid production., [RefSeq, PubMed]; X11 and X11L regulate the glutamate receptor micro-localization to the extrasynaptic region, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH49;Q8BMF2", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006886 intracellular protein transport;GO:0007626 locomotory behavior;GO:0015031 protein transport;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B2RUJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YVF0-1", "uniprot_id": [ { "id": "AKAP5_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YVF0", "type": "external" } ], "mass": 79397.0, "length": 745, "protein_name": "A-kinase anchor protein 5", "gene_name": "Akap5", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 5", "refseq_ac": [ { "id": "NP_001094941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094941", "type": "external" } ], "gene_names_uniprotkb": "Akap5; Akap150", "gene_names_refseq": "3526401B18Rik; AKAP 150; AKAP-5; AKAP150; Akap5; Gm258; P150", "protein_names_uniprotkb": "A-kinase anchor protein 5; A-kinase anchor protein 150 kDa; AKAP 150; AKAP-5; P150; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein", "protein_names_refseq": "A kinase (PRKA) anchor protein 5; A-kinase anchor protein 150 kDa; A-kinase anchor protein 5; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:238276); (R-MMU-399719)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17110924;17270471;21183079;21750661;30059200;38413375;38509283", "class_list": "", "function": "AKAP150 protein levels were increased upon exposing mice to the novel context independent of the training protocol. After habituation, only mice that learned to associate the context with the footshock showed an upregulation of AKAP150., [RefSeq, PubMed]; AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Publication Status: Online-Only, [RefSeq, PubMed]; Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (By similarity). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (PubMed:17110924). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses., [UniProtKB, UniProtKB, PubMed]; Regulation of depressive-like behaviours by palmitoylation: Role of AKAP150 in the basolateral amygdala., [RefSeq, PubMed]; The association of AKAP150 with TREK channels integrates them into a postsynaptic scaffold where both G-protein-coupled membrane receptors and TREK-1 dock simultaneously., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z5C9", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0001934 positive regulation of protein phosphorylation;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:1900273 positive regulation of long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "D3YVF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGT5-1", "uniprot_id": [ { "id": "ALAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGT5", "type": "external" } ], "mass": 57944.0, "length": 522, "protein_name": "Alanine aminotransferase 2", "gene_name": "Gpt2", "organism": "Mouse", "refseq_name": "alanine aminotransferase 2", "refseq_ac": [ { "id": "NP_776291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776291", "type": "external" } ], "gene_names_uniprotkb": "Gpt2; Aat2", "gene_names_refseq": "4631422C05Rik; ALT2; Gpt2", "protein_names_uniprotkb": "Alanine aminotransferase 2; 2.6.1.2; ALT2; GPT 2; Glutamate pyruvate transaminase 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2", "protein_names_refseq": "alanine aminotransferase 2; glutamate pyruvate transaminase 2; glutamic--alanine transaminase 2; glutamic--pyruvic transaminase 2", "tax_id": 10090, "disease": "neurodevelopmental disorder with spastic paraplegia and microcephaly (Disease Ontology:DOID:0070542); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); liver cancer (Disease Ontology:DOID:3571); amino acid metabolic disorder (Disease Ontology:DOID:9252); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:108682); (R-MMU-8964540)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15122758;21750661;23576753;25865565;27601654;34428180;37453647", "class_list": "", "function": "Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate., [UniProtKB]; Data suggest that Alt2/Gpt2 (but not Alt1/Gpt1) is induced in liver of obese mice (male ob/ob mice compared to lean C57BL/6J mice)., [RefSeq, PubMed]; The GPT2 gene demonstrates increasing expression in brain in the early postnatal period, and GPT2 protein localizes to mitochondria. Akin to the human phenotype, Gpt2-null mice exhibit reduced brain growth. Through metabolomics and direct isotope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVY7;Q8K1J3", "ec_number_list": [ { "id": "2.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006094 gluconeogenesis;GO:0042851 L-alanine metabolic process;GO:0042853 L-alanine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BGT5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CB42-1", "uniprot_id": [ { "id": "ALKB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P0CB42", "type": "external" } ], "mass": 43746.0, "length": 389, "protein_name": "Nucleic acid dioxygenase ALKBH1", "gene_name": "Alkbh1", "organism": "Mouse", "refseq_name": "nucleic acid dioxygenase ALKBH1", "refseq_ac": [ { "id": "NP_001096035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096035", "type": "external" } ], "gene_names_uniprotkb": "Alkbh1; Abh; Alkbh", "gene_names_refseq": "2700073G19Rik; Abh; Alkbh1; Alkbh; alkB; hABH", "protein_names_uniprotkb": "Nucleic acid dioxygenase ALKBH1; 1.14.11.-; 1.14.11.33; 1.14.11.51; 4.2.99.18; Alkylated DNA repair protein alkB homolog 1; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; mRNA N(3)-methylcytidine demethylase; tRNA N1-methyl adenine demethylase", "protein_names_refseq": "Alkylated DNA repair protein alkB homolog 1; DNA 6mA demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA demethylase ALKBH1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; alkB, alkylation repair homolog 1; alpha-ketoglutarate-dependent dioxygenase ABH1; mRNA N(3)-methylcytidine demethylase; nucleic acid dioxygenase ALKBH1; tRNA N1-methyl adenine demethylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:211064)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "18163532;21072209;21750661;22961808;23825659;25428506;25605945;27027282;27745969;31219806;34003800;34428180;35018683;36058506;36989111", "class_list": "", "function": "ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease., [RefSeq, PubMed]; Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation., [RefSeq, PubMed]; Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging., [RefSeq, PubMed]; DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis., [RefSeq, PubMed]; Data suggest that Alkbh1 mediates gene regulation in spermatogenesis, and that Alkbh1 is essential for normal sex-ratio distribution and embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]; Dioxygenase that acts on nucleic acids, such as DNA and tRNA (PubMed:27027282, PubMed:27745969). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:27027282). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (By similarity). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (By similarity). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (By similarity). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (By similarity). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:27027282). N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (PubMed:27027282). Demethylates mRNAs containing N(3)-methylcytidine modification (By similarity). Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity (By similarity). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (By similarity). DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (By similarity). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation (PubMed:23825659). May play a role in placental trophoblast lineage differentiation (PubMed:18163532)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Results suggest that ALKBH1 is involved in neural development by modifying the methylation status of histone H2A., [RefSeq, PubMed]; The N[6]-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis by disrupting NRF1 binding capacity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" }, { "id": "1.14.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.54", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0000049 tRNA binding;GO:0008198 ferrous iron binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P0CB42-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3E1-1", "uniprot_id": [ { "id": "AL3B2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3E1", "type": "external" } ], "mass": 52983.0, "length": 479, "protein_name": "Aldehyde dehydrogenase family 3 member B2", "gene_name": "Aldh3b2", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase family 3 member B2", "refseq_ac": [ { "id": "NP_001170909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170909", "type": "external" } ], "gene_names_uniprotkb": "Aldh3b2", "gene_names_refseq": "Aldh3b2; C130048D07Rik", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member B2; 1.2.1.3; 1.2.1.48; Aldehyde dehydrogenase 8; Aldh3B2; Long-chain fatty aldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase 8; aldehyde dehydrogenase family 3 member B2; long-chain fatty aldehyde dehydrogenase", "tax_id": 10090, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (mmu:621603); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25286108;34370553;34428180;37828378", "class_list": "", "function": "ALDH3B2 acts to remove lipid-derived aldehydes in lipid droplets generated via oxidative stress as a quality control mechanism., [RefSeq, PubMed]; Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome., [RefSeq, PubMed]; Oxidizes medium and long chain fatty aldehydes in lipid droplets into non-toxic fatty acids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497U8", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0050061 long-chain fatty aldehyde dehydrogenase (NAD+) activity;GO:0052814 medium-chain fatty aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q3E1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UUF8-1", "uniprot_id": [ { "id": "AN34B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UUF8", "type": "external" } ], "mass": 55417.0, "length": 508, "protein_name": "Ankyrin repeat domain-containing protein 34B", "gene_name": "Ankrd34b", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 34B", "refseq_ac": [ { "id": "NP_780664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780664", "type": "external" } ], "gene_names_uniprotkb": "Ankrd34b; Dp58", "gene_names_refseq": "6430502M16Rik; Ankrd34b; DP58", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 34B; Dendritic cell progenitor protein of 58 kDa", "protein_names_refseq": "ankyrin repeat domain-containing protein 34B; cytosolic phosphoprotein DP58; dendritic cell progenitor protein of 58 kDa; dendritic phosphoprotein 58 kDa; dendritic protein of 58 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:218440)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15358210;16452087;17485271;19524877;21183079;21750661", "class_list": "", "function": "Because of its restricted expression in bone-marrow-drived progenitors as a phophorylated protein, it is likely that DP58 may be involved in a signaling pathway for cellular differentiation., [RefSeq, PubMed]; Cytosolic phosphoprotein DP58 is involved in promyeloid progenitor induction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA01;Q8BVH7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UUF8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07724-1", "uniprot_id": [ { "id": "ALBU_MOUSE", "url": "https://www.uniprot.org/uniprot/P07724", "type": "external" } ], "mass": 68693.0, "length": 608, "protein_name": "Albumin", "gene_name": "Alb", "organism": "Mouse", "refseq_name": "albumin preproprotein", "refseq_ac": [ { "id": "NP_033784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033784", "type": "external" } ], "gene_names_uniprotkb": "Alb; Alb-1; Alb1", "gene_names_refseq": "Alb-1; Alb1; Alb; BCL001; BCL002; BPL001", "protein_names_uniprotkb": "Albumin", "protein_names_refseq": "albumin 1; albumin preproprotein; serum albumin", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); pre-eclampsia (Disease Ontology:DOID:10591); esophageal varix (Disease Ontology:DOID:112); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); heart disease (Disease Ontology:DOID:114); familial hyperlipidemia (Disease Ontology:DOID:1168); protein-energy malnutrition (Disease Ontology:DOID:11801); nephrotic syndrome (Disease Ontology:DOID:1184); alcoholic hepatitis (Disease Ontology:DOID:12351); leukemia (Disease Ontology:DOID:1240); twin-to-twin transfusion syndrome (Disease Ontology:DOID:13576); cholestasis (Disease Ontology:DOID:13580); obstructive jaundice (Disease Ontology:DOID:13603); root caries (Disease Ontology:DOID:14089); Reye syndrome (Disease Ontology:DOID:14525); pancreatic cancer (Disease Ontology:DOID:1793); hyperthyroxinemia (Disease Ontology:DOID:2855); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); blood protein disease (Disease Ontology:DOID:620); gastric cardia adenocarcinoma (Disease Ontology:DOID:6271); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:11657); (R-MMU-114608); (R-MMU-159418); (R-MMU-189451); (R-MMU-189483); (R-MMU-2168880); (R-MMU-381426); (R-MMU-8957275); (R-MMU-8964058); (R-MMU-9707564); (R-MMU-9749641); (R-MMU-9757110); (R-MMU-9793528)", "pathway_count": 13, "publication_count": 33, "publication_id_list": "1286668;17322886;1971802;19801983;20173027;21183079;21913724;23386199;23806337;2452956;26495903;26740625;28011936;30899053;31044023;31112734;31219806;31361958;32152506;33725478;34428180;34887587;35820727;35984892;36288343;36583994;37453647;37507081;39627609;8133041;8245790;8746565;9126960", "class_list": "", "function": "Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes albumin, an abundant plasma protein essential for maintaining oncotic pressure that functions as a carrier protein for various molecules such as steriods and fatty acids in blood. This gene is primarily expressed in liver where the encoded protein undergoes proteolytic processing before secretion into the plasma. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV03;Q61802;Q8C7C7;Q8C7H3;Q8CG74", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005504 fatty acid binding;GO:0008270 zinc ion binding;GO:0015643 toxic substance binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0009267 cellular response to starvation;GO:0051902 negative regulation of mitochondrial depolarization;GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0072732 cellular response to calcium ion starvation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P07724-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLB8-1", "uniprot_id": [ { "id": "AN34C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLB8", "type": "external" } ], "mass": 58171.0, "length": 534, "protein_name": "Ankyrin repeat domain-containing protein 34C", "gene_name": "Ankrd34c", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 34C", "refseq_ac": [ { "id": "NP_997143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997143", "type": "external" } ], "gene_names_uniprotkb": "Ankrd34c", "gene_names_refseq": "Ankrd34c; B230218L05Rik; Gm771", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 34C", "protein_names_refseq": "ankyrin repeat domain-containing protein 34C", "tax_id": 10090, "disease": "", "pathway": " (mmu:330998)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0071546 pi-body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BLB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHT0-1", "uniprot_id": [ { "id": "AL4A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHT0", "type": "external" } ], "mass": 61841.0, "length": 562, "protein_name": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "gene_name": "Aldh4a1", "organism": "Mouse", "refseq_name": "delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_780647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780647", "type": "external" } ], "gene_names_uniprotkb": "Aldh4a1", "gene_names_refseq": "A930035F14Rik; Ahd-1; Ahd1; Aldh4a1; Aldh4; Aldh5a1; E330022C09; P5cdhl; P5cdhs; P5cdh; P5cd; Ssdh1", "protein_names_uniprotkb": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase", "protein_names_refseq": "L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hyperprolinemia type 2 (Disease Ontology:DOID:0080543)", "pathway": " (mmu:212647); (R-MMU-389661); (R-MMU-70688)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "22516612;22868767;23576753;23806337;25428506;30084848;30779550;31219806;34428180;36288343;37453647;37507081;38109905", "class_list": "", "function": "Atherosclerotic Autoantigen ALDH4A1 as a Novel Immunological Indicator for Plaque Erosion in Patients with ST Segment Elevated Myocardial Infarction., [RefSeq, PubMed]; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXW8;Q7TND0;Q8BXM3;Q8R0N1;Q8R1S2", "ec_number_list": [ { "id": "1.2.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.88", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CHT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJG0-1", "uniprot_id": [ { "id": "AGO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJG0", "type": "external" } ], "mass": 97304.0, "length": 860, "protein_name": "Protein argonaute-2", "gene_name": "Ago2", "organism": "Mouse", "refseq_name": "protein argonaute-2", "refseq_ac": [ { "id": "NP_694818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694818", "type": "external" } ], "gene_names_uniprotkb": "Ago2; Eif2c2; Kiaa4215", "gene_names_refseq": "1110029L17Rik; 2310051F07Rik; Ago2; Eif2c2; Gerp95; Gm10365; mKIAA4215", "protein_names_uniprotkb": "Protein argonaute-2; 3.1.26.n2; Argonaute RISC catalytic component 2; Argonaute2; Eukaryotic translation initiation factor 2C 2; Piwi/argonaute family protein meIF2C2; Protein slicer; eIF-2C 2; eIF2C 2; mAgo2", "protein_names_refseq": "Piwi/Argonaute family protein meIF2C2; argonaute 2; argonaute RISC catalytic component 2; eukaryotic translation initiation factor 2C, 2; protein argonaute-2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); glaucoma (Disease Ontology:DOID:1686); morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (mmu:239528); (R-MMU-203927); (R-MMU-426486); (R-MMU-426496); (R-MMU-5578749)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12526743;15284456;16357216;16800626;17626790;19174539;19898466;22508726;22735451;24882364;25697406;26009488;28528544;29311329;31219806;31289130;34203471;34428180", "class_list": "", "function": "Essential for mouse development and cells lacking Argonaute2 are unable to mount an experimental response to siRNAs, [RefSeq, PubMed]; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. Regulates lymphoid and erythroid development and function, and this is independent of endonuclease activity., [UniProtKB, PubMed, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1A563;Q4VAB3;Q571J6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" }, { "id": "3.1.26.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.3", "type": "external" } ], "go_molecular_function": "GO:1905172 RISC complex binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8CJG0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2H6-1", "uniprot_id": [ { "id": "APC10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2H6", "type": "external" } ], "mass": 21266.0, "length": 185, "protein_name": "Anaphase-promoting complex subunit 10", "gene_name": "Anapc10", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 10 isoform 1", "refseq_ac": [ { "id": "NP_081180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081180", "type": "external" } ], "gene_names_uniprotkb": "Anapc10; Apc10", "gene_names_refseq": "1500026N15Rik; A830003M23Rik; APC10; Anapc10", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 10; APC10; Cyclosome subunit 10", "protein_names_refseq": "anaphase-promoting complex subunit 10 isoform 1; cyclosome subunit 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:68999); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 6, "publication_id_list": "22190705;23328397;23806337;31219806;34428180;36210013", "class_list": "", "function": "ANAPC10 was mainly expressed in the cytoplasm of spermatogonia and leptotene and pachytene spermatocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW24", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0141198 protein branched polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K2H6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y97-1", "uniprot_id": [ { "id": "ALDOB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Y97", "type": "external" } ], "mass": 39507.0, "length": 364, "protein_name": "Fructose-bisphosphate aldolase B", "gene_name": "Aldob", "organism": "Mouse", "refseq_name": "fructose-bisphosphate aldolase B", "refseq_ac": [ { "id": "NP_659152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659152", "type": "external" } ], "gene_names_uniprotkb": "Aldob; Aldo2", "gene_names_refseq": "Aldo-2; Aldo2; Aldob", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase B; 4.1.2.13; Aldolase 2; Liver-type aldolase", "protein_names_refseq": "fructose-bisphosphate aldolase B; liver-type aldolase", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); peritonitis (Disease Ontology:DOID:8283); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hereditary fructose intolerance syndrome (Disease Ontology:DOID:9869)", "pathway": " (mmu:230163); (R-MMU-70171); (R-MMU-70263); (R-MMU-70350)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "17242355;21183079;23806337;25428506;25637246;34428180;35122041;37453647;38972375", "class_list": "glycogene", "function": "Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:25637246). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)., [UniProtKB, PubMed, PubMed]; Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency., [RefSeq, PubMed]; This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K034;Q91W73", "ec_number_list": [ { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005815 microtubule organizing center;GO:0030868 smooth endoplasmic reticulum membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0010043 response to zinc ion;GO:0006094 gluconeogenesis;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91Y97-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZK0-1", "uniprot_id": [ { "id": "AP2D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZK0", "type": "external" } ], "mass": 49548.0, "length": 452, "protein_name": "Transcription factor AP-2-delta", "gene_name": "Tfap2d", "organism": "Mouse", "refseq_name": "transcription factor AP-2-delta isoform 1", "refseq_ac": [ { "id": "NP_694794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694794", "type": "external" } ], "gene_names_uniprotkb": "Tfap2d; Tcfap2d", "gene_names_refseq": "Tcfap2d; Tfap2d", "protein_names_uniprotkb": "Transcription factor AP-2-delta; AP2-delta; Activating enhancer-binding protein 2-delta", "protein_names_refseq": "AP2-delta; activating enhancer-binding protein 2-delta; transcription factor AP-2-delta isoform 1", "tax_id": 10090, "disease": "sleep disorder (Disease Ontology:DOID:535)", "pathway": " (mmu:226896); (R-MMU-8866904); (R-MMU-8866907)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11522791;12711551;31297132;37081114", "class_list": "", "function": "Oxidative stress inhibits the expression of Prestin protein, and the transcription mechanism is triggered to compensate for the loss of Prestin protein in HEI-OC1 cells. AP-2delta is one of the important TFs that suppresses transcription of the Prestin gene, and AP-2delta suppression further boosted Prestin mRNA activation under oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC., [UniProtKB, PubMed]; The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MCU6", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91ZK0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JB7-1", "uniprot_id": [ { "id": "AMNLS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JB7", "type": "external" } ], "mass": 48696.0, "length": 458, "protein_name": "Protein amnionless", "gene_name": "Amn", "organism": "Mouse", "refseq_name": "protein amnionless precursor", "refseq_ac": [ { "id": "NP_291081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291081", "type": "external" } ], "gene_names_uniprotkb": "Amn", "gene_names_refseq": "Amn", "protein_names_uniprotkb": "Protein amnionless", "protein_names_refseq": "protein amnionless precursor; protein amnionless; type I transmembrane protein", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); megaloblastic anemia (Disease Ontology:DOID:13382); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:93835)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11279523;15342463;9851841", "class_list": "", "function": "Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:15342463). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a type I transmembrane protein. The encoded protein is an essential component of the cubulin receptor complex which is thought to play a role in coordinating growth and patterning of the embryo. This protein is thought to modulate a bone morphogenetic protein (BMP) signaling pathway. A homoygous mutation in the mouse gene results in the lack of an amnion in embryos. Mutations in the human gene are associated with Megaloblastic Anemia-1. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0U1;Q99MP9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005905 clathrin-coated pit;GO:0016020 membrane;GO:0043235 receptor complex;GO:0045177 apical part of cell", "go_biological_process": "GO:0097017 renal protein absorption;GO:0006898 receptor-mediated endocytosis;GO:0009235 cobalamin metabolic process;GO:0008104 intracellular protein localization;GO:0015889 cobalamin transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99JB7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBR0-1", "uniprot_id": [ { "id": "AKAP8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBR0", "type": "external" } ], "mass": 76294.0, "length": 687, "protein_name": "A-kinase anchor protein 8", "gene_name": "Akap8", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 8 isoform 1", "refseq_ac": [ { "id": "NP_062748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062748", "type": "external" } ], "gene_names_uniprotkb": "Akap8; Akap95", "gene_names_refseq": "1200016A02Rik; AKAP-8; AKAP95; Akap8", "protein_names_uniprotkb": "A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; AKAP 95; AKAP-8", "protein_names_refseq": "A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8 isoform 1; A-kinase anchor protein 95 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:56399)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12082153;12414807;14641107;16227597;16751186;19144319;19531803;21183079;21750661;22872234;23342911;24129315;25153642;28135057;28528544;31219806;32719551;34428180;40997131", "class_list": "", "function": "Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (By similarity). Specifically involved in recruitment of CAPD2 to, and condensation of maternal but not paternal chromosomes (PubMed:12082153). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (By similarity). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (PubMed:19531803)., [UniProtKB, UniProtKB, UniProtKB]; Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis., [RefSeq, PubMed]; This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]; This study showed an increase in the level of global DNA methylation starting in oocytes with diameters around 60 microm, increases in histone h4, and decreases in AKAP95., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0L8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0045087 innate immune response;GO:0032720 negative regulation of tumor necrosis factor production;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9DBR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYB5-1", "uniprot_id": [ { "id": "ADDG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYB5", "type": "external" } ], "mass": 78777.0, "length": 706, "protein_name": "Gamma-adducin", "gene_name": "Add3", "organism": "Mouse", "refseq_name": "gamma-adducin isoform a", "refseq_ac": [ { "id": "NP_001157571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157571", "type": "external" } ], "gene_names_uniprotkb": "Add3; Addl", "gene_names_refseq": "Add3", "protein_names_uniprotkb": "Gamma-adducin; Adducin-like protein 70", "protein_names_refseq": "adducin 3 (gamma); adducin-like protein 70; cytoskeletal protein; gamma-adducin isoform a; gamma-adducin", "tax_id": 10090, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); hypertension (Disease Ontology:DOID:10763); biliary atresia (Disease Ontology:DOID:13608); cerebral palsy (Disease Ontology:DOID:1969); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:27360); (R-MMU-5223345); (R-MMU-9035034)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10602987;16682971;17242355;21183079;21750661;22706708;25428506;25605945;30084848;33992672;34428180;37828378", "class_list": "", "function": "C-terminal 38 amino acids of gamma-adducin interact with F-actins around the Golgi complex, to facilitate exit of POMC/ACTH vesicles., [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (By similarity). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (PubMed:33992672)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9486, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZT6;Q9D2M5;Q9QYB6", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding;GO:0003779 actin binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0051495 positive regulation of cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0045907 positive regulation of vasoconstriction;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QYB5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYB8-1", "uniprot_id": [ { "id": "ADDB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYB8", "type": "external" } ], "mass": 80642.0, "length": 725, "protein_name": "Beta-adducin", "gene_name": "Add2", "organism": "Mouse", "refseq_name": "beta-adducin isoform 1", "refseq_ac": [ { "id": "NP_001258786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258786", "type": "external" } ], "gene_names_uniprotkb": "Add2", "gene_names_refseq": "2900072M03Rik; Add2; add97", "protein_names_uniprotkb": "Beta-adducin; Add97; Erythrocyte adducin subunit beta", "protein_names_refseq": "adducin 2 (beta); beta-adducin isoform 1; beta-adducin; erythrocyte adducin subunit beta; snoRNA MBII-396", "tax_id": 10090, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); hypertension (Disease Ontology:DOID:10763); cerebral palsy (Disease Ontology:DOID:1969); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (mmu:11519); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10602987;10845937;15345747;15728854;16452087;16765915;17114649;17242355;21183079;21750661;26495903;29032200;31209405;31219806;40885482", "class_list": "", "function": "Beta-Adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory. Erratum:[J Neurosci. 2005 Apr 6;25(14):1 p following 3627], [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity)., [UniProtKB]; Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction., [RefSeq, PubMed]; This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0E1;Q80VH9;Q8C1C4;Q9CXE3;Q9JLE4;Q9JLE5;Q9QYB7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0051017 actin filament bundle assembly;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QYB8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JME5-1", "uniprot_id": [ { "id": "AP3B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JME5", "type": "external" } ], "mass": 119193.0, "length": 1082, "protein_name": "AP-3 complex subunit beta-2", "gene_name": "Ap3b2", "organism": "Mouse", "refseq_name": "AP-3 complex subunit beta-2", "refseq_ac": [ { "id": "NP_067467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067467", "type": "external" } ], "gene_names_uniprotkb": "Ap3b2", "gene_names_refseq": "Ap3b2; Naptb; [b]-NAP; beta-NAP; beta3B", "protein_names_uniprotkb": "AP-3 complex subunit beta-2; Adaptor protein complex AP-3 subunit beta-2; Adaptor-related protein complex 3 subunit beta-2; Beta-3B-adaptin; Clathrin assembly protein complex 3 beta-2 large chain", "protein_names_refseq": "AP-3 complex beta-2 subunit; AP-3 complex subunit beta-2; adapter-related protein complex 3 subunit beta-2; adaptor protein complex AP-3 beta-2 subunit; adaptor protein complex AP-3 subunit beta-2; adaptor-related protein complex 3 subunit beta-2; adaptor-related protein complex AP-3, beta 2 subunit; beta-3B-adaptin; beta3B-adaptin; clathrin assembly protein complex 3 beta-2 large chain", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 48 (Disease Ontology:DOID:0080448)", "pathway": " (mmu:11775)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10679242;17114649;21183079;21750661;21998198;25605945;33300544;34428180", "class_list": "", "function": "Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RTK2;Q3UYP8;Q6QR53;Q8R1E5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0030665 clathrin-coated vesicle membrane;GO:0005802 trans-Golgi network;GO:0030123 AP-3 adaptor complex;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008344 adult locomotory behavior;GO:0016192 vesicle-mediated transport;GO:0008089 anterograde axonal transport;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JME5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1E0-1", "uniprot_id": [ { "id": "FOXO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1E0", "type": "external" } ], "mass": 69518.0, "length": 652, "protein_name": "Forkhead box protein O1", "gene_name": "Foxo1", "organism": "Mouse", "refseq_name": "forkhead box protein O1", "refseq_ac": [ { "id": "NP_062713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062713", "type": "external" } ], "gene_names_uniprotkb": "Foxo1; Fkhr; Foxo1a", "gene_names_refseq": "Afxh; FKHR; Fkhr1; Foxo1a; Foxo1", "protein_names_uniprotkb": "Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma", "protein_names_refseq": "forkhead box O1a; forkhead box protein O1A; forkhead box protein O1; forkhead in rhabdomyosarcoma; forkhead protein 1", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:56458); (R-MMU-198693); (R-MMU-211163); (R-MMU-5687128); (R-MMU-9614399); (R-MMU-9617629); (R-MMU-9617828)", "pathway_count": 7, "publication_count": 68, "publication_id_list": "10347145;12219087;12754525;15184386;15220471;16076959;16917544;17050673;17090532;17242355;17627282;17681146;18388859;18951090;19037106;19965929;20061393;20519497;20668652;21183079;21196578;21317886;21335550;21471200;22298775;22417654;22510882;22532369;23705021;24116102;24466179;24730386;25009184;25142777;25153642;25428506;25944660;27457971;27827363;28052965;28267764;28270438;28528544;28644433;28790135;28851713;30002415;30014903;30174230;31442424;32103177;32782141;32783937;32848054;33138208;33229443;33408127;34208360;34428180;34678516;34914893;35966593;36852467;38191912;38861834;40021952;40885482;40997131", "class_list": "", "function": "Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:12219087, PubMed:12754525, PubMed:15184386, PubMed:15220471, PubMed:16917544, PubMed:17090532, PubMed:17627282, PubMed:17681146, PubMed:20519497, PubMed:20668652, PubMed:21196578, PubMed:21335550, PubMed:21471200, PubMed:22298775, PubMed:22417654, PubMed:22510882, PubMed:27457971, PubMed:34914893). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:17090532, PubMed:21335550). Activity suppressed by insulin (PubMed:12754525, PubMed:17627282). Main regulator of redox balance and osteoblast numbers and controls bone mass (PubMed:21471200, PubMed:22298775). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (PubMed:21471200, PubMed:22298775). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (PubMed:22298775). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (PubMed:21471200). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (PubMed:12219087, PubMed:27457971). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (PubMed:12754525, PubMed:25009184). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity). Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (PubMed:21196578). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (By similarity). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 40, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJW4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0031625 ubiquitin protein ligase binding;GO:0008134 transcription factor binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0032869 cellular response to insulin stimulus;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "Q9R1E0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06986-1", "uniprot_id": [ { "id": "SIAH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06986", "type": "external" } ], "mass": 34758.0, "length": 325, "protein_name": "E3 ubiquitin-protein ligase SIAH2", "gene_name": "Siah2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SIAH2", "refseq_ac": [ { "id": "NP_033200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033200", "type": "external" } ], "gene_names_uniprotkb": "Siah2", "gene_names_refseq": "Siah2; Sinh2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SIAH2; 2.3.2.27; RING-type E3 ubiquitin transferase SIAH2; Seven in absentia homolog 2; Siah-2; mSiah2", "protein_names_refseq": "E3 ubiquitin-protein ligase SIAH2; RING-type E3 ubiquitin transferase SIAH2; mSiah2; seven in absentia 2; seven in absentia homolog 2; siah-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20439); (R-MMU-5689880); (R-MMU-983168)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10681424;11257006;12417719;14645235;14645526;17003045;24809345;26070566;26392558;33082319;33155406;35789210;37078793;7895278;8404535;9637679", "class_list": "", "function": "''The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism''. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:24809345, PubMed:26070566, PubMed:9637679). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (By similarity). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with EBF1 and ZFP521 to Promote Adipogenesis., [RefSeq, PubMed]; Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q06986-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61743-1", "uniprot_id": [ { "id": "KCJ11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61743", "type": "external" } ], "mass": 43562.0, "length": 390, "protein_name": "ATP-sensitive inward rectifier potassium channel 11", "gene_name": "Kcnj11", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 11 isoform 1", "refseq_ac": [ { "id": "NP_034732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034732", "type": "external" } ], "gene_names_uniprotkb": "Kcnj11", "gene_names_refseq": "Kcnj11; Kir6.2; mBIR", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 11; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 11 isoform 1; ATP-sensitive inward rectifier potassium channel 11; inward rectifier K(+) channel Kir6.2", "tax_id": 10090, "disease": "permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); transient neonatal diabetes mellitus 3 (Disease Ontology:DOID:0061172); familial hyperinsulinemic hypoglycemia 2 (Disease Ontology:DOID:0070218); Parkinsonism (Disease Ontology:DOID:0080855); maturity-onset diabetes of the young type 13 (Disease Ontology:DOID:0111110); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); hyperinsulinism (Disease Ontology:DOID:2018); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16514); (R-MMU-1296025); (R-MMU-382556); (R-MMU-422356); (R-MMU-5578775)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "21750661;35820727;7502040;8549751", "class_list": "", "function": "Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). In pancreatic cells, it forms KATP channels with ABCC8/SUR1 (By similarity). Can form cardiac and smooth muscle-type KATP channels with ABCC9 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QX21", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031072 heat shock protein binding;GO:0044325 transmembrane transporter binding;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0030955 potassium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0071333 cellular response to glucose stimulus;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61743-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97287-1", "uniprot_id": [ { "id": "MCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97287", "type": "external" } ], "mass": 35217.0, "length": 331, "protein_name": "Induced myeloid leukemia cell differentiation protein Mcl-1 homolog", "gene_name": "Mcl1", "organism": "Mouse", "refseq_name": "induced myeloid leukemia cell differentiation protein Mcl-1 homolog", "refseq_ac": [ { "id": "NP_032588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032588", "type": "external" } ], "gene_names_uniprotkb": "Mcl1", "gene_names_refseq": "Gm52627; Mcl-1; Mcl1", "protein_names_uniprotkb": "Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Bcl-2-related protein EAT/mcl1", "protein_names_refseq": "bcl-2-related protein EAT/mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:17210)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "15550399;16543145;18589438;19919825;21502331;21546903;24213575;26495903;27013495;27449090;31219806;34203471;34428180;36210013;9655929;9671497", "class_list": "", "function": "Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2K6L9;Q3TUS0;Q792P0;Q9CRI4", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity;GO:0015267 channel activity;GO:0044877 protein-containing complex binding;GO:0051434 BH3 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97287-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35593-1", "uniprot_id": [ { "id": "PSDE_MOUSE", "url": "https://www.uniprot.org/uniprot/O35593", "type": "external" } ], "mass": 34577.0, "length": 310, "protein_name": "Ubiquitin C-terminal hydrolase PSMD14", "gene_name": "Psmd14", "organism": "Mouse", "refseq_name": "ubiquitin C-terminal hydrolase PSMD14", "refseq_ac": [ { "id": "NP_067501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067501", "type": "external" } ], "gene_names_uniprotkb": "Psmd14; Pad1", "gene_names_refseq": "2610312C03Rik; 3200001M20Rik; Pad1; Poh1; Psmd14; rpm11", "protein_names_uniprotkb": "Ubiquitin C-terminal hydrolase PSMD14; 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit RPN11; 3.4.19.12; MAD1", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 14; 26S proteasome non-ATPase subunit; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated pad1 homolog; MAD1; proteasome 26S subunit, non-ATPase 14; ubiquitin C-terminal hydrolase PSMD14", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658)", "pathway": " (mmu:59029); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 4, "publication_id_list": "33300544;34428180;34572530;9727008", "class_list": "", "function": "An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. Regulates macroautophagy by ensuring Golgi-to-ER retrograde transport through its deubiquitinating activity on K63-linked ubiquitin chains. This activity prevents the retention of essential autophagy proteins at the Golgi, enabling their trafficking to autophagosome formation sites and supporting Golgi-ER membrane recycling critical for effective autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB50;Q9CZY6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0045471 response to ethanol;GO:0070536 protein K63-linked deubiquitination;GO:0016241 regulation of macroautophagy;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35593-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62187-1", "uniprot_id": [ { "id": "TTF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62187", "type": "external" } ], "mass": 97723.0, "length": 859, "protein_name": "Transcription termination factor 1", "gene_name": "Ttf1", "organism": "Mouse", "refseq_name": "transcription termination factor 1 isoform a", "refseq_ac": [ { "id": "NP_033468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033468", "type": "external" } ], "gene_names_uniprotkb": "Ttf1", "gene_names_refseq": "TTF-1; TTF-I; Ttf1", "protein_names_uniprotkb": "Transcription termination factor 1; RNA polymerase I termination factor; TTF-1; TTF-I; Transcription termination factor I; mTFF-I", "protein_names_refseq": "RNA polymerase I termination factor; transcription termination factor 1 isoform a; transcription termination factor 1; transcription termination factor I", "tax_id": 10090, "disease": "", "pathway": " (mmu:22130); (R-MMU-5683826); (R-MMU-73762); (R-MMU-73863)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "15292447;17242355;20173027;20513429;21183079;25428506;25605945;30084848;30779550;31543703;34428180;7720715;9049305;9092622;9267035;9582279", "class_list": "", "function": "Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin (PubMed:15292447, PubMed:7720715, PubMed:9049305, PubMed:9267035). Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription (PubMed:15292447, PubMed:20513429). Interaction with BAZ2A/TIP5 recovers DNA-binding activity (PubMed:15292447)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The data suggest that the N-terminal repeats of mouse TTF1, and by analogy those of human TTF1, cooperate to mediate both nucleolar localization and ARF binding Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKK5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006338 chromatin remodeling;GO:0008156 negative regulation of DNA replication;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62187-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXJ1-1", "uniprot_id": [ { "id": "APBB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXJ1", "type": "external" } ], "mass": 77384.0, "length": 710, "protein_name": "Amyloid beta precursor protein binding family B member 1", "gene_name": "Apbb1", "organism": "Mouse", "refseq_name": "amyloid beta precursor protein binding family B member 1 isoform 1", "refseq_ac": [ { "id": "NP_001240814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240814", "type": "external" } ], "gene_names_uniprotkb": "Apbb1; Fe65; Rir", "gene_names_refseq": "Apbb1; Fe65; Rir", "protein_names_uniprotkb": "Amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65", "protein_names_refseq": "amyloid beta (A4) precursor protein-binding, family B, member 1; amyloid beta precursor protein binding family B member 1 isoform 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:11785); (R-MMU-5693565)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "17121854;19343227;21183079;21750661;22645316;25342469;25397632;25757569;26255939;26276215;27734846;32848054;40885482;8894693;9407065", "class_list": "", "function": "Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling., [RefSeq, PubMed]; Results provide strong evidence that Fe65 plays a role in DNA damage response and cell viability by epigenomic regulation of specific transcriptional programs activated upon genotoxic stress., [RefSeq, PubMed]; These data demonstrate a role for FE65 proteins at central and peripheral synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription coregulator that can have both coactivator and corepressor functions (PubMed:17121854, PubMed:25342469). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:17121854, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) (By similarity). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (By similarity). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (PubMed:27734846). Plays a role in the maintenance of lens transparency (PubMed:25757569). May play a role in muscle cell strength (PubMed:25757569, PubMed:27734846). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNW5;O08642;Q3TPU0;Q8BNF4;Q8BSR9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006939 smooth muscle contraction;GO:0008542 visual learning;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QXJ1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UTH8-1", "uniprot_id": [ { "id": "ARHG9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UTH8", "type": "external" } ], "mass": 60927.0, "length": 516, "protein_name": "Rho guanine nucleotide exchange factor 9", "gene_name": "Arhgef9", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 9 isoform a", "refseq_ac": [ { "id": "NP_001028501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028501", "type": "external" } ], "gene_names_uniprotkb": "Arhgef9; Kiaa0424", "gene_names_refseq": "9630036L12Rik; Arhgef9", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 9; Collybistin; Rac/Cdc42 guanine nucleotide exchange factor 9", "protein_names_refseq": "CDC42 guanine nucleotide exchange factor (GEF) 9; collybistin; rac/Cdc42 guanine nucleotide exchange factor 9; rho guanine nucleotide exchange factor 9 isoform a; rho guanine nucleotide exchange factor 9", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 8 (Disease Ontology:DOID:0080215)", "pathway": " (mmu:236915); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148); (R-MMU-9013406); (R-MMU-977443)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "11168555;16616186;17690689;19236916;21183079;21750661;27609886;30087324", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity)., [UniProtKB, UniProtKB]; Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization., [RefSeq, PubMed]; Collybistin binds the GABAAR-alpha2-subunit with high affinity Publication Status: Online-Only, [RefSeq, PubMed]; Data provide the first evidence that collybistin deficiency leads to significant changes of GABAergic inhibition, network excitability and synaptic plasticity in vivo., [RefSeq, PubMed]; The resolution crystal structure of the Cdc42-collybistin II complex reveals a novel conformation of the switch I region of Cdc42, and biochemical data indicate that gephyrin negatively regulates collybistin activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXI3;B1AXI5;B9EJ88;Q3TQ60;Q80U06;Q8CAF9", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0043113 receptor clustering;GO:0099150 regulation of postsynaptic specialization assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UTH8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIZ1-1", "uniprot_id": [ { "id": "ANS1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIZ1", "type": "external" } ], "mass": 139047.0, "length": 1259, "protein_name": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "gene_name": "Anks1b", "organism": "Mouse", "refseq_name": "ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 4", "refseq_ac": [ { "id": "NP_001170868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170868", "type": "external" } ], "gene_names_uniprotkb": "Anks1b", "gene_names_refseq": "AIDA-1b; AIDA-1; Anks1b; C030032C09Rik; E530015N03Rik; EB-1; Gm10937; Gm1555", "protein_names_uniprotkb": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; E2A-PBX1-associated protein; EB-1", "protein_names_refseq": "E2A-PBX1-associated protein; amyloid-beta protein intracellular domain-associated protein 1; ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform 4; ankyrin repeat and sterile alpha motif domain-containing protein 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:77531)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15169875;17875921;18034455;21183079;21750661;22645316;24636920;25457551;26085624;33300544;34678516;38129387", "class_list": "", "function": "AIDA-1 regulates NMDAR subunit localization at synapses by facilitating transport of GluN2B., [RefSeq, PubMed]; ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells., [UniProtKB, UniProtKB, UniProtKB]; It induces PUMA protein activation, which involved in apoptosis., [RefSeq, PubMed]; It inhibits Eg5, which reduces neurotrophin and neurotransmitter receptor function., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9Q644;Q4KMR9;Q8BJ47;Q8BJ49", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0099565 chemical synaptic transmission, postsynaptic;GO:1900383 regulation of synaptic plasticity by receptor localization to synapse;GO:0097120 receptor localization to synapse;GO:0099527 postsynapse to nucleus signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BIZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TR1-1", "uniprot_id": [ { "id": "AGRL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TR1", "type": "external" } ], "mass": 161686.0, "length": 1466, "protein_name": "Adhesion G protein-coupled receptor L1", "gene_name": "Adgrl1", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor L1 precursor", "refseq_ac": [ { "id": "NP_851382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851382", "type": "external" } ], "gene_names_uniprotkb": "Adgrl1; Kiaa0821; Lec2; Lphn1", "gene_names_refseq": "2900070I05Rik; Adgrl1; CLIBA; Lec2; Lphn1; mKIAA0821", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L1; CIRL-1; Calcium-independent alpha-latrotoxin receptor 1; Latrophilin-1; Lectomedin-2", "protein_names_refseq": "CIRL-1; G protein coupled receptor Lec2; adhesion G protein-coupled receptor L1 precursor; calcium-independent alpha-latrotoxin receptor 1; latrophilin-1; lectomedin-2", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:330814)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12679517;17114649;18547526;19524596;21183079;21750661;22405201;24129315;30899004;33300544;34428180;35820727;35907405;37944639;38664368;38684366;40885482", "class_list": "", "function": "Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells (PubMed:35907405). Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity. Publication Status: Online-Only, [RefSeq, PubMed]; Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH90;Q7TNE5;Q80T49", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0015643 toxic substance binding;GO:0050839 cell adhesion molecule binding;GO:0016524 latrotoxin receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone;GO:0045202 synapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q80TR1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWG8-1", "uniprot_id": [ { "id": "ARRB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWG8", "type": "external" } ], "mass": 46973.0, "length": 418, "protein_name": "Beta-arrestin-1", "gene_name": "Arrb1", "organism": "Mouse", "refseq_name": "beta-arrestin-1 isoform A", "refseq_ac": [ { "id": "NP_796205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796205", "type": "external" } ], "gene_names_uniprotkb": "Arrb1", "gene_names_refseq": "1200006I17Rik; Arrb1; G430100A01Rik", "protein_names_uniprotkb": "Beta-arrestin-1; Arrestin beta-1", "protein_names_refseq": "beta-arrestin-1 isoform A; beta-arrestin-1; beta-arrestin1", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); major depressive disorder (Disease Ontology:DOID:1470); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:109689); (R-MMU-418555); (R-MMU-432720); (R-MMU-432722); (R-MMU-456926); (R-MMU-5635838); (R-MMU-5674135); (R-MMU-5689880); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9839389)", "pathway_count": 11, "publication_count": 11, "publication_id_list": "14534298;17947660;18337459;18497258;21183079;21750661;23886940;25147978;38083975;38883814;39082138", "class_list": "", "function": "AMPK Attenuation of beta-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of beta-Arrestin-1-ser330., [RefSeq, PubMed]; Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:38883814). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation (PubMed:38883814). The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in IL8-mediated granule release in neutrophils. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Involved in smoothened (SMO) localization to primary cilium (PubMed:18497258). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH (PubMed:23886940). Participates in the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940). Involved in some MRGPRE-mediated signaling required to improve glucose tolerance: promotes phosphorylation of ALDOA downstream of MRGPRE activation, increasing glycolysis and leading to GLP-1 secretion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH95;Q8BTJ5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003713 transcription coactivator activity;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006897 endocytosis;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BWG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWY8-1", "uniprot_id": [ { "id": "ASAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWY8", "type": "external" } ], "mass": 127421.0, "length": 1147, "protein_name": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1", "gene_name": "Asap1", "organism": "Mouse", "refseq_name": "arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b", "refseq_ac": [ { "id": "NP_001263390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263390", "type": "external" } ], "gene_names_uniprotkb": "Asap1; Ddef1; Kiaa1249; Shag1", "gene_names_refseq": "Asap1; DEF-1; Ddef1; PAP; mKIAA1249; s19", "protein_names_uniprotkb": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; DEF-1; Development and differentiation-enhancing factor 1; Differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP", "protein_names_refseq": "130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; PIP2-dependent ARF1 GAP; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; development and differentiation-enhancing factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13196); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10022919;12149250;12771146;17242355;18685082;21183079;21750661;22517741;22645316;30084848;31246957;32782141;32848054;34428180;34678516;37875175;40021952;40885482;9126384;9819391", "class_list": "", "function": "May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)., [UniProtKB, UniProtKB]; MiR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1., [RefSeq, PubMed]; Together these observations suggest that ASAP1 plays a decisive role during the differentiation of mesenchymal progenitor cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O08612;Q505F0;Q80TG8;Q80UV6;Q99LV8;Q9Z2B6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0061000 negative regulation of dendritic spine development;GO:0071803 positive regulation of podosome assembly;GO:1903527 positive regulation of membrane tubulation;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9QWY8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98078-1", "uniprot_id": [ { "id": "DAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P98078", "type": "external" } ], "mass": 82312.0, "length": 766, "protein_name": "Disabled homolog 2", "gene_name": "Dab2", "organism": "Mouse", "refseq_name": "disabled homolog 2 isoform b", "refseq_ac": [ { "id": "NP_001008702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008702", "type": "external" } ], "gene_names_uniprotkb": "Dab2; Doc2", "gene_names_refseq": "5730435J12Rik; D15Wsu122e; D630005B22Rik; Dab2; Doc-2; Doc2; p96", "protein_names_uniprotkb": "Disabled homolog 2; Adaptor molecule disabled-2; DOC-2; Differentially expressed in ovarian carcinoma 2; Mitogen-responsive phosphoprotein", "protein_names_refseq": "adaptor molecule disabled-2; differentially expressed in ovarian carcinoma 2; disabled homolog 2 isoform b; disabled homolog 2; mitogen-responsive phosphoprotein", "tax_id": 10090, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:13132); (R-MMU-190873); (R-MMU-196025); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 36, "publication_id_list": "11104669;11247302;11368898;11823414;11906161;11927540;12234931;12413896;12606711;12826668;12877983;14596919;15592455;15596140;15734730;15894542;16263760;16870701;16984970;19144319;19581931;20881059;21183079;21750661;22323290;22648170;24252604;25153642;25428506;31219806;32782141;34428180;36210013;38702433;7775479;9569023", "class_list": "", "function": "Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Isoform p96 is involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Isoform p67 is not involved in LDL receptor endocytosis. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. Isoform p67 may be involved in transcriptional regulation. May act as a tumor suppressor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3K1;Q91W56;Q923E1", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0035612 AP-2 adaptor complex binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0097017 renal protein absorption;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0015031 protein transport;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P98078-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCT6-1", "uniprot_id": [ { "id": "BAP18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCT6", "type": "external" } ], "mass": 17996.0, "length": 171, "protein_name": "BPTF-associated chromatin complex component 1", "gene_name": "Bacc1", "organism": "Mouse", "refseq_name": "BPTF-associated chromatin complex component 1 isoform 1", "refseq_ac": [ { "id": "NP_001171072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171072", "type": "external" } ], "gene_names_uniprotkb": "Bacc1; 0610010K14Rik; Bap18", "gene_names_refseq": "0610010K14Rik; 1110020A23Rik; Bacc1; Bap18", "protein_names_uniprotkb": "BPTF-associated chromatin complex component 1; BPTF-associated protein of 18 kDa; Chromatin complex subunit BAP18", "protein_names_refseq": "BPTF-associated chromatin complex component 1 isoform 1; BPTF-associated protein of 18 kDa; MLL1/MLL complex subunit C17orf49 homolog; chromatin complex subunit BAP18; chromatin complexes subunit BAP18", "tax_id": 10090, "disease": "", "pathway": " (mmu:104457)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19131326;21183079;21750661;34428180", "class_list": "", "function": "Component of chromatin complexes such as the MLL1/MLL and NURF complexes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFE6;Q7TMP3;Q9D183", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0071339 MLL1 complex;GO:0016589 NURF complex;GO:0005634 nucleus", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1B1-1", "uniprot_id": [ { "id": "CAMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1B1", "type": "external" } ], "mass": 164333.0, "length": 1461, "protein_name": "Calmodulin-regulated spectrin-associated protein 2", "gene_name": "Camsap2", "organism": "Mouse", "refseq_name": "calmodulin-regulated spectrin-associated protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001334039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334039", "type": "external" } ], "gene_names_uniprotkb": "Camsap2; Camsap1l1; Kiaa1078", "gene_names_refseq": "1600013L13Rik; 4930541M15Rik; Camsap1l1; Camsap2; mKIAA1078", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 2; Calmodulin-regulated spectrin-associated protein 1-like protein 1", "protein_names_refseq": "calmodulin-regulated spectrin-associated protein 1-like protein 1; calmodulin-regulated spectrin-associated protein 2 isoform 3; calmodulin-regulated spectrin-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67886)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15345747;16452087;21183079;21750661;23169647;25428506;30084848;31219806;32482850;36207462;37814859;38839944", "class_list": "", "function": "CAMSAP2 and -3 work together to maintain noncentrosomal microtubules in epithelial cells, suppressing the microtubule-organizing ability of the centrosome., [RefSeq, PubMed]; CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Deficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells., [RefSeq, PubMed]; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (By similarity). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity)., [UniProtKB, UniProtKB]; [High expression of CAMSAP2 promotes invasion and metastasis of gastric cancer cells by upregulating TGF-beta signaling]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNI4;Q80TK8;Q8C4J5", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0036064 ciliary basal body;GO:0036449 microtubule minus-end", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0033043 regulation of organelle organization;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C1B1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8K5-1", "uniprot_id": [ { "id": "ANK3_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8K5", "type": "external" } ], "mass": 214062.0, "length": 1961, "protein_name": "Ankyrin-3", "gene_name": "Ank3", "organism": "Mouse", "refseq_name": "ankyrin-3 isoform g", "refseq_ac": [ { "id": "NP_033800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033800", "type": "external" } ], "gene_names_uniprotkb": "Ank3", "gene_names_refseq": "2900054D09Rik; Ank-3; Ank3; AnkG; Ankyrin-3; Ankyrin-G", "protein_names_uniprotkb": "Ankyrin-3; ANK-3; Ankyrin-G", "protein_names_refseq": "ankyrin-3 isoform g; brain-specific ankyrin-G", "tax_id": 10090, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); autosomal recessive intellectual developmental disorder 37 (Disease Ontology:DOID:0081202); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); post-traumatic stress disorder (Disease Ontology:DOID:2055); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:11735)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16452088;18550753;19109891;19458039;21183079;21223964;21750661;23903368;33300544;34203471;34428180;35820727;37507081;7615634;9060470", "class_list": "", "function": "Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (PubMed:19109891). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G5E8K4;O08866;O08867;Q3TSJ8;Q4U205;Q4U206;Q4U256;Q4U260;Q61305;Q61306;Q61307;Q61308;Q61309;Q61310;Q8CBN3;Q8VC68", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0045806 negative regulation of endocytosis;GO:0099612 protein localization to axon;GO:0007009 plasma membrane organization;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "G5E8K5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ05-1", "uniprot_id": [ { "id": "ARAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ05", "type": "external" } ], "mass": 193398.0, "length": 1703, "protein_name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2", "gene_name": "Arap2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arap2; Centd1; Gm148; Kiaa0580", "gene_names_refseq": "", "protein_names_uniprotkb": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; Centaurin-delta-1; Cnt-d1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:212285); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16452087;18034455;21183079;21750661;25428506;25605945;31599954;34428180;35820727;36210013", "class_list": "", "function": "Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80TX2;Q8C3T2;Q8VEL6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BZ05-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C033-1", "uniprot_id": [ { "id": "ARHGA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C033", "type": "external" } ], "mass": 147946.0, "length": 1345, "protein_name": "Rho guanine nucleotide exchange factor 10", "gene_name": "Arhgef10", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 10 isoform b", "refseq_ac": [ { "id": "NP_001032825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032825", "type": "external" } ], "gene_names_uniprotkb": "Arhgef10; Kiaa0294", "gene_names_refseq": "6430549H08Rik; Arhgef10; mKIAA0294", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 10", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 10; rho guanine nucleotide exchange factor 10 isoform b", "tax_id": 10090, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:234094); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14508709;21183079;21750661;28528544;28799234;29456827;33300544;34428180;35820727;37828378", "class_list": "", "function": "ARHGEF10 serves as an important regulator of platelet shape change, spreading, and aggregation and plays important role in arterial thrombosis formation., [RefSeq, PubMed]; May play a role in developmental myelination of peripheral nerves., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Social behavior is impaired in Arhgef10 knockout mice. ARHGEF10 is a candidate risk gene for ASD. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU38;Q80VH8;Q8BW76;Q922S7", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0035025 positive regulation of Rho protein signal transduction;GO:0022011 myelination in peripheral nervous system", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8C033-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB20-1", "uniprot_id": [ { "id": "ATPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB20", "type": "external" } ], "mass": 23364.0, "length": 213, "protein_name": "ATP synthase peripheral stalk subunit OSCP, mitochondrial", "gene_name": "Atp5po", "organism": "Mouse", "refseq_name": "ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor", "refseq_ac": [ { "id": "NP_613063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613063", "type": "external" } ], "gene_names_uniprotkb": "Atp5po; Atp5o; D12Wsu28e", "gene_names_refseq": "ATPO; Atp5o; Atp5po; D12Wsu28e; OSCP", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit OSCP, mitochondrial; ATP synthase subunit O; OSCP; Oligomycin sensitivity conferral protein", "protein_names_refseq": "ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor; ATP synthase peripheral stalk subunit OSCP, mitochondrial; ATP synthase subunit O, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit; DNA segment, Chr 12, Wayne State University 28, expressed; oligomycin sensitivity conferral protein", "tax_id": 10090, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 7 (Disease Ontology:DOID:0070464); Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459); Leigh disease (Disease Ontology:DOID:3652); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:28080); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "21750661;23576753;23806337;25605945;29550215;33254080;33300544;34428180;35820727;36288343;37453647;37507081;39927985", "class_list": "", "function": "Estrogen receptor beta modulates mitochondrial permeability transition by regulating CypD interaction with OSCP., [RefSeq, PubMed]; Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology., [RefSeq, PubMed]; Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:1903924 estradiol binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043209 myelin sheath", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0071345 cellular response to cytokine stimulus;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9DB20-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0G6-1", "uniprot_id": [ { "id": "COMP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0G6", "type": "external" } ], "mass": 82342.0, "length": 755, "protein_name": "Cartilage oligomeric matrix protein", "gene_name": "Comp", "organism": "Mouse", "refseq_name": "cartilage oligomeric matrix protein precursor", "refseq_ac": [ { "id": "NP_057894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057894", "type": "external" } ], "gene_names_uniprotkb": "Comp", "gene_names_refseq": "Comp; TSP5", "protein_names_uniprotkb": "Cartilage oligomeric matrix protein; COMP", "protein_names_refseq": "cartilage oligomeric matrix protein precursor; thrombospondin-5", "tax_id": 10090, "disease": "multiple epiphyseal dysplasia 1 (Disease Ontology:DOID:0070303); carpal tunnel syndrome 2 (Disease Ontology:DOID:0070467); pseudoachondroplasia (Disease Ontology:DOID:0080047); multiple epiphyseal dysplasia (Disease Ontology:DOID:12721); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:12845); (R-MMU-216083)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11052496;12426368;21183079;21624478;21750661;25428506;32686688;32747625;37584842;38479555;39187041", "class_list": "", "function": "COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-beta Signaling Pathway., [RefSeq, PubMed]; COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways., [RefSeq, PubMed]; Endonuclear Circ-calm4 regulates ferroptosis via a circR-Loop of the COMP gene in pulmonary artery smooth muscle cells., [RefSeq, PubMed]; Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin (PubMed:32686688). Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3X8Q4", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex;GO:1990341 thrombospondin complex", "go_biological_process": "GO:0016485 protein processing;GO:0043066 negative regulation of apoptotic process;GO:0050881 musculoskeletal movement;GO:0050905 neuromuscular process;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R0G6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YE5-1", "uniprot_id": [ { "id": "BAZ2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YE5", "type": "external" } ], "mass": 209618.0, "length": 1889, "protein_name": "Bromodomain adjacent to zinc finger domain protein 2A", "gene_name": "Baz2a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Baz2a; Kiaa0314; Tip5", "gene_names_refseq": "", "protein_names_uniprotkb": "Bromodomain adjacent to zinc finger domain protein 2A; TTF-I-interacting protein 5; Tip5; Transcription termination factor I-interacting protein 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:116848)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11532953;12198165;15292447;16085498;16678107;17242355;18600236;19578370;20173027;21183079;21750661;23806337;25428506;25605945;30084848;34203471;34428180;35820727;40997131", "class_list": "", "function": "Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11532953). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:11532953). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (By similarity). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (By similarity). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (PubMed:11532953). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (PubMed:12198165, PubMed:16085498). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (PubMed:11532953, PubMed:16085498). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (PubMed:16678107, PubMed:18600236)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3U235;Q80U42", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0000183 rDNA heterochromatin formation;GO:0016479 negative regulation of transcription by RNA polymerase I;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q91YE5-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02357-1", "uniprot_id": [ { "id": "ANK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02357", "type": "external" } ], "mass": 204227.0, "length": 1862, "protein_name": "Ankyrin-1", "gene_name": "Ank1", "organism": "Mouse", "refseq_name": "ankyrin-1 isoform 1", "refseq_ac": [ { "id": "NP_001104253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104253", "type": "external" } ], "gene_names_uniprotkb": "Ank1; Ank-1", "gene_names_refseq": "Ank-1; Ank1; nb; pale", "protein_names_uniprotkb": "Ankyrin-1; ANK-1; Erythrocyte ankyrin", "protein_names_refseq": "ankyrin-1 isoform 1; ankyrin-1; erythrocyte ankyrin; normoblastic anemia", "tax_id": 10090, "disease": "hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); malaria (Disease Ontology:DOID:12365); hereditary spherocytosis (Disease Ontology:DOID:12971); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:11733); (R-MMU-445095); (R-MMU-447043); (R-MMU-6807878)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "1386265;16452087;17242355;18034455;21177872;21183079;21750661;25428506;26495903;30084848;34428180;39125973;8486643;9024692;9628825", "class_list": "", "function": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Novel Identification of Ankyrin-R in Cardiac Fibroblasts and a Potential Role in Heart Failure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70440;P97446;P97941;Q3TZ35;Q3UH42;Q3UHP2;Q3UYY7;Q61302;Q61303;Q78E45", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051117 ATPase binding;GO:0044325 transmembrane transporter binding;GO:0030507 spectrin binding;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045211 postsynaptic membrane;GO:0030673 axolemma;GO:0043005 neuron projection", "go_biological_process": "GO:0007165 signal transduction;GO:0055085 transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q02357-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQC5-1", "uniprot_id": [ { "id": "APTX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQC5", "type": "external" } ], "mass": 38723.0, "length": 342, "protein_name": "Aprataxin", "gene_name": "Aptx", "organism": "Mouse", "refseq_name": "aprataxin isoform b", "refseq_ac": [ { "id": "NP_001020615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020615", "type": "external" } ], "gene_names_uniprotkb": "Aptx", "gene_names_refseq": "2410016G21Rik; Aptx; FHA-HIT", "protein_names_uniprotkb": "Aprataxin; 3.6.1.71; 3.6.1.72; FHA-HIT; Forkhead-associated domain histidine triad-like protein", "protein_names_refseq": "aprataxin isoform b; forkhead-associated domain histidine triad-like protein", "tax_id": 10090, "disease": "early-onset ataxia with oculomotor apraxia and hypoalbuminemia (Disease Ontology:DOID:0050754); olivopontocerebellar atrophy (Disease Ontology:DOID:14784)", "pathway": " (mmu:66408)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11586300;16964241;17242355;19103743;21183079;21750661;25274775;29477978;31219806;31599954;34428180", "class_list": "", "function": "Aprataxin participates in chromosomal single-strand break repair, [RefSeq, PubMed]; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Interaction with phosphorylated XRCC1 is a requirement for significant APTX recruitment to cellular DNA damage and enzymatic activity in cell extracts., [RefSeq, PubMed]; Neurological disorders associated with APTX mutations may be caused by the gradual accumulation of unrepaired DNA strand breaks resulting from abortive DNA ligation events, [RefSeq, PubMed]; Study demonstrates a protective role of Aptx in vivo and suggests that its loss results in progressive accumulation of DNA breaks in the nervous system, triggering hallmarks of premature ageing, systemically., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPA7;Q8C2B5;Q8K3D1;Q9CQ59", "ec_number_list": [ { "id": "3.6.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.71", "type": "external" }, { "id": "3.6.1.72", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.72", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0000012 single strand break repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TQC5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2F0-1", "uniprot_id": [ { "id": "BRD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2F0", "type": "external" } ], "mass": 79762.0, "length": 726, "protein_name": "Bromodomain-containing protein 3", "gene_name": "Brd3", "organism": "Mouse", "refseq_name": "bromodomain-containing protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001107045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107045", "type": "external" } ], "gene_names_uniprotkb": "Brd3; Fsrg2", "gene_names_refseq": "2410084F24Rik; Brd3; Fsrg2; ORFX; RINGL3", "protein_names_uniprotkb": "Bromodomain-containing protein 3; Bromodomain-containing FSH-like protein FSRG2", "protein_names_refseq": "bromodomain-containing FSH-like protein FSRG2; bromodomain-containing protein 3 isoform 2; bromodomain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67382)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15128596;16008511;17242355;21183079;21536911;21555453;21750661;28733670;32848054;32895492;35822049;40885482;40997131", "class_list": "", "function": "A conserved but uncharacterized gene encoding Brd3, which was down-regulated during endothelial differentiation, was identified., [RefSeq, PubMed]; Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:21536911). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (By similarity). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:21536911). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (PubMed:21536911, PubMed:21555453)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; More strongly expressed in developing testis compared with ovary, [RefSeq, PubMed]; Using pharmacological assay and RNA interference, BRD3 down-regulation resulted in enhanced myogenic differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8C665;Q8CAX7;Q9JI25", "ec_number_list": [], "go_molecular_function": "GO:0140693 molecular condensate scaffold activity;GO:0062072 histone H3K9me2/3 reader activity;GO:0106222 lncRNA binding;GO:0140566 histone reader activity;GO:0140038 histone H3K27cr reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8K2F0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGH7-1", "uniprot_id": [ { "id": "C42S2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGH7", "type": "external" } ], "mass": 9223.0, "length": 84, "protein_name": "CDC42 small effector protein 2", "gene_name": "Cdc42se2", "organism": "Mouse", "refseq_name": "CDC42 small effector protein 2", "refseq_ac": [ { "id": "NP_848741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848741", "type": "external" } ], "gene_names_uniprotkb": "Cdc42se2", "gene_names_refseq": "2810404F18Rik; Cdc42se2; SPEC2", "protein_names_uniprotkb": "CDC42 small effector protein 2", "protein_names_refseq": "CDC42 small effector protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72729)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15840583;21183079;21750661;26495903;34678516", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKN9", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70345-1", "uniprot_id": [ { "id": "B2CL2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70345", "type": "external" } ], "mass": 20790.0, "length": 193, "protein_name": "Bcl-2-like protein 2", "gene_name": "Bcl2l2", "organism": "Mouse", "refseq_name": "bcl-2-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_031563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031563", "type": "external" } ], "gene_names_uniprotkb": "Bcl2l2; Bclw; Kiaa0271", "gene_names_refseq": "Bcl-w; Bcl2l2; Gtrgal2; Gtrosa41; bclw; c98", "protein_names_uniprotkb": "Bcl-2-like protein 2; Apoptosis regulator Bcl-W; Bcl2-L-2; c98", "protein_names_refseq": "apoptosis regulator Bcl-W; bcl-2-like protein 2 isoform 1; bcl-2-like protein 2", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); Burkitt lymphoma (Disease Ontology:DOID:8584)", "pathway": " (mmu:12050)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11784036;14746907;21546903;21750661;34428180;39067448;8761287;9500547", "class_list": "", "function": "Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor., [RefSeq, PubMed]; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q545Q4;Q6A093;Q8CFR2;Q8CGL4;Q9CYW5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015267 channel activity;GO:0044877 protein-containing complex binding;GO:0097718 disordered domain specific binding;GO:0051400 BH domain binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0035795 negative regulation of mitochondrial membrane permeability;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70345-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07440-1", "uniprot_id": [ { "id": "B2LA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07440", "type": "external" } ], "mass": 19914.0, "length": 172, "protein_name": "Bcl-2-related protein A1", "gene_name": "Bcl2a1", "organism": "Mouse", "refseq_name": "bcl-2-related protein A1", "refseq_ac": [ { "id": "NP_033872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033872", "type": "external" } ], "gene_names_uniprotkb": "Bcl2a1; A1; Bcl2a1a; Bfl1", "gene_names_refseq": "A1; Bcl2a1a; Bcl2a1; Bfl-1; Hbpa1", "protein_names_uniprotkb": "Bcl-2-related protein A1; A1-A; Hemopoietic-specific early response protein; Protein BFL-1", "protein_names_refseq": "A1-A; bcl-2-related protein A1; hemopoietic-specific early response protein; protein BFL-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12044)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11888890;18250455;18462686;32555150;34428180;35820727;37839511;39285161;8345191;9645611", "class_list": "", "function": "Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-XL in a murine cell model of myeloid differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (PubMed:11888890)., [UniProtKB, PubMed]; Social defeat stress enhances the rewarding effects of cocaine through alpha1A adrenoceptors in the medial prefrontal cortex of mice., [RefSeq, PubMed]; The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q07440-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810B3-1", "uniprot_id": [ { "id": "BSH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810B3", "type": "external" } ], "mass": 25862.0, "length": 232, "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "Bsx", "organism": "Mouse", "refseq_name": "brain-specific homeobox protein homolog", "refseq_ac": [ { "id": "NP_839976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839976", "type": "external" } ], "gene_names_uniprotkb": "Bsx", "gene_names_refseq": "Bsx1a; Bsx1b; Bsx", "protein_names_uniprotkb": "Brain-specific homeobox protein homolog", "protein_names_refseq": "brain-specific homeobox protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:244813)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14678827;17353277;17485440;17550780;17944879", "class_list": "", "function": "Binding of REST to neuron restrictive silencer element suppresses transcriptional activator Sp1-mediated activation of bsx in non-neuronal cells, [RefSeq, PubMed]; DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance., [UniProtKB, PubMed, PubMed, PubMed]; Data demonstrate that BSX1A is a DNA binding protein and a transcriptional activator, and that BSX1A and BSX1B localize in the nuclei and cytoplasm, respectively., [RefSeq, PubMed]; Might be considered an important molecular marker for early embryonic stages of epiphysis development., [RefSeq, PubMed]; These results demonstrate that Bsx is required for postnatal growth and maintenance of lactating mammary glands., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SXB1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007626 locomotory behavior;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q810B3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQG9-1", "uniprot_id": [ { "id": "CERT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQG9", "type": "external" } ], "mass": 71111.0, "length": 624, "protein_name": "Ceramide transfer protein", "gene_name": "Cert1", "organism": "Mouse", "refseq_name": "ceramide transfer protein isoform 2", "refseq_ac": [ { "id": "NP_001157694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157694", "type": "external" } ], "gene_names_uniprotkb": "Cert1; Cert; Col4a3bp; Stard11", "gene_names_refseq": "2810404O15Rik; 9230101K08Rik; CERT; Cert1; Col4a3bp; GPBP", "protein_names_uniprotkb": "Ceramide transfer protein; CERT; Collagen type IV alpha-3-binding protein; GPBP; Goodpasture antigen-binding protein; START domain-containing protein 11; StAR-related lipid transfer protein 11; StARD11", "protein_names_refseq": "START domain-containing protein 11; ceramide transfer protein isoform 2; ceramide transfer protein; ceramide transport protein; collagen type IV alpha-3-binding protein; collagen, type IV, alpha 3 (Goodpasture antigen) binding protein; goodpasture antigen-binding protein; procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein; stAR-related lipid transfer protein 11; stARD11", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 34 (Disease Ontology:DOID:0070064)", "pathway": " (mmu:68018)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11007769;15504975;17242355;21183079;30139741", "class_list": "glycogene", "function": "Shelters ceramides inside its steroidogenic acute regulatory lipid transfer (START) domain and mediates their intracellular trafficking in a non-vesicular manner from the endoplasmic reticulum to the Golgi apparatus for conversion to sphingomyelin. Efficiently transfers ceramide molecules having long-chain fatty chains, but not those with very long acyl chains. Capable of transferring diacylglycerol, although with very low efficiency., [UniProtKB, UniProtKB]; The size and number of multivesicular bodies were comparable in WT and STARD11-knockout cells. In conclusion, we propose a model of how STARD11 mediates ceramide trafficking in palmitate-treated cells and stimulates exosome biogenesis., [RefSeq, PubMed]; VEGF inhibitor also partially prevented the stimulation of alpha3(IV) collagen by transforming growth factor (TGF)-beta1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQF6;Q8BNN8;Q8C8H3;Q8CAR3;Q91WB1;Q9CU52;Q9EQG8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0016301 kinase activity;GO:0097001 ceramide binding;GO:0120017 ceramide transfer activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0001701 in utero embryonic development;GO:0006936 muscle contraction;GO:0007165 signal transduction;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQG9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70704-1", "uniprot_id": [ { "id": "AT8A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70704", "type": "external" } ], "mass": 131413.0, "length": 1164, "protein_name": "Phospholipid-transporting ATPase IA", "gene_name": "Atp8a1", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase IA isoform a", "refseq_ac": [ { "id": "NP_001034088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034088", "type": "external" } ], "gene_names_uniprotkb": "Atp8a1; Atpc1", "gene_names_refseq": "APLT; Atp3a2; Atp8a1; B230107D19Rik; ClassI", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IA; 7.6.2.1; ATPase class I type 8A member 1; Chromaffin granule ATPase II; P4-ATPase flippase complex alpha subunit ATP8A1", "protein_names_refseq": "ATPase 8A1, aminophospholipid transporter (APLT), class I; ATPase 8A1, p type; ATPase class I type 8A member 1; ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; P4-ATPase flippase complex alpha subunit ATP8A1; chromaffin granule ATPase II; phospholipid-transporting ATPase IA isoform a; probable phospholipid-transporting ATPase IA", "tax_id": 10090, "disease": "", "pathway": " (mmu:11980); (R-MMU-6798695); (R-MMU-936837)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11801660;14975727;16618126;16643453;17242355;19144319;20224745;21183079;21750661;22007859;23269685;26495903;27287255;29187734;30084848;30674456;30779550;33300544;34428180;36930333;37723322;9548971", "class_list": "", "function": "Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1., [RefSeq, PubMed]; Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function., [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:16618126, PubMed:20224745). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:16618126, PubMed:20224745). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (PubMed:23269685). Acts as aminophospholipid translocase at the cell membrane in neuronal cells; the activity is associated with hippocampus-dependent learning (PubMed:22007859). May play a role in brain connectivity (PubMed:27287255)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Role in normal phospholipid distribution in the bilayer, and for normal binding, penetration, and signaling by the zona pellucida, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR88", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090556 phosphatidylserine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007612 learning;GO:0030335 positive regulation of cell migration;GO:0045332 phospholipid translocation;GO:0061092 positive regulation of phospholipid translocation;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P70704-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PE2-1", "uniprot_id": [ { "id": "ANRA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PE2", "type": "external" } ], "mass": 34063.0, "length": 312, "protein_name": "Ankyrin repeat family A protein 2", "gene_name": "Ankra2", "organism": "Mouse", "refseq_name": "ankyrin repeat family A protein 2 isoform d", "refseq_ac": [ { "id": "NP_075961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075961", "type": "external" } ], "gene_names_uniprotkb": "Ankra2; Ankra", "gene_names_refseq": "1110004M18Rik; Ankra2; Ankra", "protein_names_uniprotkb": "Ankyrin repeat family A protein 2; RFXANK-like protein 2", "protein_names_refseq": "RFXANK-like protein 2; ankyrin repeat family A protein 2 isoform d; ankyrin repeat family A protein 2; ankyrin repeat, family A (RFXANK-like), 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68558)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11095640;15964851;16236793;17949687;21750661", "class_list": "", "function": "ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression, [RefSeq, PubMed]; Class II histone deacetylases (HDACs)4 and HDAC5 interact with the ankyrin repeats of ANKRA2 and regulatory factor X-associated ankyrin-containing protein and, through association with RFXANK, repress MHC II promoter activation, [RefSeq, PubMed]; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin (PubMed:11095640)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0043254 regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99PE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQX6-1", "uniprot_id": [ { "id": "ANKS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQX6", "type": "external" } ], "mass": 93474.0, "length": 883, "protein_name": "Ankyrin repeat and SAM domain-containing protein 6", "gene_name": "Anks6", "organism": "Mouse", "refseq_name": "ankyrin repeat and SAM domain-containing protein 6 isoform 1", "refseq_ac": [ { "id": "NP_001343355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001343355", "type": "external" } ], "gene_names_uniprotkb": "Anks6; Gm635; Samd6", "gene_names_refseq": "2210417J20Rik; Ankrd14; Anks6; Gm635; SamCystin; Samd6; b2b1801.1Clo", "protein_names_uniprotkb": "Ankyrin repeat and SAM domain-containing protein 6; SAM domain-containing protein 6; SamCystin; Sterile alpha motif domain-containing protein 6", "protein_names_refseq": "ankyrin repeat and SAM domain-containing protein 6 isoform 1; ankyrin repeat and SAM domain-containing protein 6; ankyrin repeat domain 14; sterile alpha motif domain containing 6; sterile alpha motif domain-containing protein 6", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); polycystic kidney disease (Disease Ontology:DOID:0080322); nephronophthisis 16 (Disease Ontology:DOID:0111124); uremia (Disease Ontology:DOID:4676); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:75691)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23793029;25671767;26039630;26327442;31041607;32886109;35032404", "class_list": "", "function": "Loss of Anks6 leads to YAP deficiency and liver abnormalities., [RefSeq, PubMed]; Mitigation of portal fibrosis and cholestatic liver disease in ANKS6-deficient livers by macrophage depletion., [RefSeq, PubMed]; Required for renal function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Anks6 affects DNA damage responses and proliferation and plays a crucial role in physiological amino acid and purine/pyrimidine metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Thus, our data demonstrate the importance of ANKS6 for kidney structure integrity and the essential mediating role of its SAM domain in the formation of protein complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097543 ciliary inversin compartment;GO:0005929 cilium", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0001822 kidney development;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6GQX6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIG8-1", "uniprot_id": [ { "id": "ANM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIG8", "type": "external" } ], "mass": 72680.0, "length": 637, "protein_name": "Protein arginine N-methyltransferase 5", "gene_name": "Prmt5", "organism": "Mouse", "refseq_name": "protein arginine N-methyltransferase 5 isoform 2", "refseq_ac": [ { "id": "NP_001300835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300835", "type": "external" } ], "gene_names_uniprotkb": "Prmt5; Jbp1; Skb1", "gene_names_refseq": "Jbp1; Prmt5; Skb1", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 5; 2.1.1.320; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; Prmt5; SKB1 homolog; Shk1 kinase-binding protein 1 homolog", "protein_names_refseq": "Jak-binding protein 1; SKB1 homolog; histone-arginine N-methyltransferase PRMT5; protein arginine N-methyltransferase 5 isoform 2; shk1 kinase-binding protein 1 homolog", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); seminoma (Disease Ontology:DOID:4440)", "pathway": " (mmu:27374); (R-MMU-191859); (R-MMU-3214858); (R-MMU-6804760)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10531356;15485929;16699504;19584108;19858291;21750661;21917714;22193545;22872234;22872859;23133559;28263986;31219806;40885482", "class_list": "", "function": "Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNN1;Q9QZS9", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CIG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1R2-1", "uniprot_id": [ { "id": "BAG6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1R2", "type": "external" } ], "mass": 121037.0, "length": 1154, "protein_name": "Large proline-rich protein BAG6", "gene_name": "Bag6", "organism": "Mouse", "refseq_name": "large proline-rich protein BAG6 isoform 1", "refseq_ac": [ { "id": "NP_476512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476512", "type": "external" } ], "gene_names_uniprotkb": "Bag6; Bat3", "gene_names_refseq": "2410045D21Rik; BAG-6; Bag6; Bat3; D17H6S52E; G3; Scythe", "protein_names_uniprotkb": "Large proline-rich protein BAG6; BAG family molecular chaperone regulator 6; BAG-6; BCL2-associated athanogene 6; HLA-B-associated transcript 3; Protein Scythe", "protein_names_refseq": "BAG family molecular chaperone regulator 6; HLA-B-associated transcript 3; large proline-rich protein BAG6 isoform 1; large proline-rich protein BAG6; large proline-rich protein BAT3; protein Scythe", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (mmu:224727)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;14656967;16287848;17242355;17403783;18056262;18250455;18299400;18678708;20173027;20485683;20713601;21183079;21750661;24160817;25428507;25605945;26337389;26495903;26876100;28135057;31219806;32782141;33649389;34428180;34678516;34887587;35820727;36210013;36288343;37828378;38498560;38942797;39172905;40885482", "class_list": "", "function": "ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:18056262, PubMed:18678708, PubMed:20713601). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20713601). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (By similarity). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (PubMed:20713601). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (By similarity). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (PubMed:18678708). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (PubMed:18056262). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly. Publication Status: Online-Only, [RefSeq, PubMed]; BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells., [RefSeq, PubMed]; Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May mediate ricin-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8SNA3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q9Z1R2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01815-1", "uniprot_id": [ { "id": "CAC1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01815", "type": "external" } ], "mass": 240138.0, "length": 2139, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1C", "gene_name": "Cacna1c", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1C isoform 2", "refseq_ac": [ { "id": "NP_001153005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153005", "type": "external" } ], "gene_names_uniprotkb": "Cacna1c; Cach2; Cacn2; Cacnl1a1; Cchl1a1", "gene_names_refseq": "Cacna1c; Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; MBC; MELC-CC; Mouse brain class C; Voltage-gated calcium channel subunit alpha Cav1.2", "protein_names_refseq": "brain class C; calcium channel voltage-dependent alpha1c subunit; neuronal voltage-gated calcium channel alpha 1C subunit; skeletal muscle-specific calcium channel; voltage-dependent L-type calcium channel subunit alpha-1C isoform 2; voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel subunit alpha Cav1.2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Timothy syndrome (Disease Ontology:DOID:0060173); neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures (Disease Ontology:DOID:0070536); Brugada syndrome 3 (Disease Ontology:DOID:0110220); long QT syndrome 8 (Disease Ontology:DOID:0110649); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:12288); (R-MMU-422356); (R-MMU-5576892); (R-MMU-5576893)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10973973;1385406;14609949;18586882;20639889;21183079;21216955;2173707;21750661;22355118;25368181;28119464;28363979;32910282;34678516;7814415", "class_list": "", "function": "Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q04476;Q61242;Q99242", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:0006939 smooth muscle contraction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q01815-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKC7-1", "uniprot_id": [ { "id": "AP4M1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKC7", "type": "external" } ], "mass": 49509.0, "length": 449, "protein_name": "AP-4 complex subunit mu-1", "gene_name": "Ap4m1", "organism": "Mouse", "refseq_name": "AP-4 complex subunit mu-1", "refseq_ac": [ { "id": "NP_067367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067367", "type": "external" } ], "gene_names_uniprotkb": "Ap4m1", "gene_names_refseq": "4930443L05Rik; Ap4m1; Ap4m4", "protein_names_uniprotkb": "AP-4 complex subunit mu-1; AP-4 adaptor complex mu subunit; Adaptor-related protein complex 4 subunit mu-1; Mu subunit of AP-4; Mu-adaptin-related protein 2; Mu4-adaptin; mu-ARP2; mu4", "protein_names_refseq": "AP-4 adapter complex mu subunit; AP-4 adaptor complex mu subunit; AP-4 complex subunit mu-1; adapter-related protein complex 4 mu-1 subunit; adapter-related protein complex 4 subunit mu-1; adaptor-related protein complex 4 subunit mu-1; adaptor-related protein complex AP-4 mu4 subunit; mu subunit of AP-4; mu-ARP2; mu-adaptin-related protein 2; mu4-adaptin", "tax_id": 10090, "disease": "hereditary spastic paraplegia 50 (Disease Ontology:DOID:0110802)", "pathway": " (mmu:11781); (R-MMU-432720)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18341993;21750661;22872234;31219806;34203471;34428180", "class_list": "", "function": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0030124 AP-4 adaptor complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0016192 vesicle-mediated transport;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKC7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1K5-1", "uniprot_id": [ { "id": "ARI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1K5", "type": "external" } ], "mass": 64017.0, "length": 555, "protein_name": "E3 ubiquitin-protein ligase ARIH1", "gene_name": "Arih1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ARIH1", "refseq_ac": [ { "id": "NP_064311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064311", "type": "external" } ], "gene_names_uniprotkb": "Arih1; Ari; Ubch7bp; Uip77", "gene_names_refseq": "Ari1; Arih1; Ari; Hari; Hhari; Ubch7bp; Uip77", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ARIH1; 2.3.2.31; ARI-1; Protein ariadne-1 homolog; UbcH7-binding protein; UbcM4-interacting protein 77; Ubiquitin-conjugating enzyme E2-binding protein 1", "protein_names_refseq": "ARI-1; E3 ubiquitin-protein ligase ARIH1; RING-type E3 ubiquitin transferase ARIH1; UbcH7-binding protein; UbcM4-interacting protein 77; ariadne 1; ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1; protein ariadne-1 homolog; ubiquitin-conjugating enzyme E2-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23806); (R-MMU-1169408); (R-MMU-9833482); (R-MMU-9909505)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10431818;10880484;11124525;21750661;23806337;25428506;25632008;26740625;28621812;31219806;33300544;34428180;36217001;39627609", "class_list": "", "function": "2,3,7,8-tetrachlorodibenzo-p-dioxin promotes the aryl hydrocarbon receptor binding to Ubch7 gene promoter as well as its transactivation, resulting in an induction of UbcH7 levels in the olfactory bulb, ventral midbrain, hippocampus, striatum, cerebral cortex, brain stem, and medulla oblongata., [RefSeq, PubMed]; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology., [UniProtKB, UniProtKB]; Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7., [RefSeq, PubMed]; The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q1X3;Q6PF92;Q8CFJ4", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z1K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61324-1", "uniprot_id": [ { "id": "ARNT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61324", "type": "external" } ], "mass": 77902.0, "length": 712, "protein_name": "Aryl hydrocarbon receptor nuclear translocator 2", "gene_name": "Arnt2", "organism": "Mouse", "refseq_name": "aryl hydrocarbon receptor nuclear translocator 2 isoform a", "refseq_ac": [ { "id": "NP_031514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031514", "type": "external" } ], "gene_names_uniprotkb": "Arnt2; Kiaa0307", "gene_names_refseq": "Arnt2; Hif-2b; bHLHe1; mKIAA0307", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2", "protein_names_refseq": "ARNT protein 2; aryl hydrocarbon receptor nuclear translocator 2 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:11864); (R-MMU-211945); (R-MMU-211976); (R-MMU-211981); (R-MMU-8937144); (R-MMU-9768919)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11025203;21750661;24129315;27782878;30846309;39180750;8657146", "class_list": "", "function": "ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy., [RefSeq, PubMed]; In the absence of synaptic excitation, ARNT2 recruits the NCoR2 co-repressor complex to suppress neuronal activity-dependent regulatory elements and maintain low basal levels of inducible genes. in response to heightened neuronal activity, ARNT2 recruits NPAS4 to activity-dependent regulatory elements to induce transcription and thereby increase somatic inhibitory input., [RefSeq, PubMed]; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQG2;Q8CHG9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0017162 aryl hydrocarbon receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61324-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAL0-1", "uniprot_id": [ { "id": "BEND3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAL0", "type": "external" } ], "mass": 94155.0, "length": 825, "protein_name": "BEN domain-containing protein 3", "gene_name": "Bend3", "organism": "Mouse", "refseq_name": "BEN domain-containing protein 3", "refseq_ac": [ { "id": "NP_950193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950193", "type": "external" } ], "gene_names_uniprotkb": "Bend3; Kiaa1553", "gene_names_refseq": "Bend3; mKIAA1553", "protein_names_uniprotkb": "BEN domain-containing protein 3", "protein_names_refseq": "BEN domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:331623)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;25457167;35143257;37650637", "class_list": "", "function": "A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation., [RefSeq, PubMed]; BEND3 is a key factor in mediating a switch from constitutive to facultative heterochromatin. Erratum:[Mol Cell. 2015 Jan 8;57(1):202. Simboeck, Elisabeth [Added]], [RefSeq, PubMed]; Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation., [RefSeq, PubMed]; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (PubMed:25457167). Stimulates the ERCC6L translocase and ATPase activities (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TC0", "ec_number_list": [], "go_molecular_function": "GO:0000182 rDNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0051260 protein homooligomerization;GO:0000183 rDNA heterochromatin formation;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PAL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AHC3-1", "uniprot_id": [ { "id": "CAMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AHC3", "type": "external" } ], "mass": 175887.0, "length": 1581, "protein_name": "Calmodulin-regulated spectrin-associated protein 1", "gene_name": "Camsap1", "organism": "Mouse", "refseq_name": "calmodulin-regulated spectrin-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001263288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263288", "type": "external" } ], "gene_names_uniprotkb": "Camsap1", "gene_names_refseq": "9530003A05Rik; Camsap1; PRO2405", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 1", "protein_names_refseq": "calmodulin-regulated spectrin-associated protein 1 isoform 1", "tax_id": 10090, "disease": "complex cortical dysplasia with other brain malformations 12 (Disease Ontology:DOID:0061141)", "pathway": " (mmu:227634)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17242355;21183079;21750661;22095662;22517741;22645316;32848054;35822049;36283405;38799061;40885482", "class_list": "", "function": "Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder., [RefSeq, PubMed]; Camsap1-expressing cells exhibit regional heterogeneity in an early phase after stab injury of mouse brain. Newly born reactive astrocytes are derived from heterogeneous Camsap1-expressing cells in the injured brain., [RefSeq, PubMed]; CircCamsap1 is dispensable for male fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQF8;Q8CBV3", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0036064 ciliary basal body;GO:0036449 microtubule minus-end;GO:0072686 mitotic spindle", "go_biological_process": "GO:0031175 neuron projection development;GO:0007010 cytoskeleton organization;GO:0031113 regulation of microtubule polymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "A2AHC3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60875-1", "uniprot_id": [ { "id": "ARHG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60875", "type": "external" } ], "mass": 111974.0, "length": 985, "protein_name": "Rho guanine nucleotide exchange factor 2", "gene_name": "Arhgef2", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 2 isoform 2", "refseq_ac": [ { "id": "NP_001185840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185840", "type": "external" } ], "gene_names_uniprotkb": "Arhgef2; Kiaa0651; Lbcl1; Lfc", "gene_names_refseq": "Arhgef2; GEF-H1; GEFH1; GEF; LFP40; Lbcl1; Lfc; P40; mKIAA0651", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 2; GEF-H1; Guanine nucleotide exchange factor H1; LBC'S first cousin; Lymphoid blast crisis-like 1; Oncogene LFC; Rhobin", "protein_names_refseq": "LBC'S first cousin; guanine nucleotide exchange factor H1; lymphoid blast crisis-like 1; oncogene LFC; rho guanine nucleotide exchange factor 2 isoform 2; rho guanine nucleotide exchange factor 2; rho/rac guanine nucleotide exchange factor (GEF) 2; rhobin", "tax_id": 10090, "disease": "neurodevelopmental disorder with midbrain and hindbrain malformations (Disease Ontology:DOID:0080312)", "pathway": " (mmu:16800); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026)", "pathway_count": 5, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;12604587;17114649;17242355;18394899;19131326;19144319;21183079;21406564;21750661;25428506;27738004;28453519;28528544;29187734;30084848;30266824;30779550;31219806;33300544;34406376;34428180;34887587;35820727;36834937;38200184;39627609;7629163", "class_list": "", "function": "Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis., [RefSeq, PubMed]; CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. Publication Status: Online-Only, [RefSeq, PubMed]; Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNW9;O09115;Q3TBI4;Q3TJ16;Q8CHE1;Q923E0;Q9ESG7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0045087 innate immune response;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q60875-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZK6-1", "uniprot_id": [ { "id": "ANKS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZK6", "type": "external" } ], "mass": 72082.0, "length": 655, "protein_name": "Ankyrin repeat and SAM domain-containing protein 3", "gene_name": "Anks3", "organism": "Mouse", "refseq_name": "ankyrin repeat and SAM domain-containing protein 3", "refseq_ac": [ { "id": "NP_082577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082577", "type": "external" } ], "gene_names_uniprotkb": "Anks3; Kiaa1977", "gene_names_refseq": "2700067D09Rik; Anks3; mKIAA1977", "protein_names_uniprotkb": "Ankyrin repeat and SAM domain-containing protein 3", "protein_names_refseq": "ankyrin repeat and SAM domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72615)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;25671767;26188091;26327442;29899363", "class_list": "", "function": "ANKS3-ANKS6 direct interaction through their SAM domain. Publication Status: Online-Only, [RefSeq, PubMed]; Anks3 N-terminal ankyrin repeats, but not SAM domain required for Nek7 interaction.Nek7 increased Ser/Thr phosphorylation of Anks3 primarily within ankyrin domain., [RefSeq, PubMed]; Combined metabolomics successfully identified 155 metabolites; 48 metabolites were identified to be significantly altered by decreasing Ankyrin repeat and sterile alpha motif domain containing 3 protein (Anks3) levels. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in vasopressin signaling in the kidney., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPF6;Q80X46", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZK6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54918-1", "uniprot_id": [ { "id": "B2L11_MOUSE", "url": "https://www.uniprot.org/uniprot/O54918", "type": "external" } ], "mass": 22067.0, "length": 196, "protein_name": "Bcl-2-like protein 11", "gene_name": "Bcl2l11", "organism": "Mouse", "refseq_name": "bcl-2-like protein 11 isoform 3", "refseq_ac": [ { "id": "NP_033884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033884", "type": "external" } ], "gene_names_uniprotkb": "Bcl2l11; Bim", "gene_names_refseq": "1500006F24Rik; Bcl2l11; Bim; Bod; bcl2-L-11", "protein_names_uniprotkb": "Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death", "protein_names_refseq": "BCL2-like 11 (apoptosis facilitator); Bcl2 interacting mediator of cell death; bcl-2-like protein 11 isoform 3; bcl-2-like protein 11; bcl2-interacting mediator of cell death", "tax_id": 10090, "disease": "", "pathway": " (mmu:12125); (R-MMU-111446); (R-MMU-111453); (R-MMU-193648)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12818176;14499110;16509771;16543145;19100675;19367708;21159964;21478148;27013495;31219806;34428180;9430630", "class_list": "", "function": "Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALQ6;O54919;O54920", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0001701 in utero embryonic development;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O54918-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58660-1", "uniprot_id": [ { "id": "CAR10_MOUSE", "url": "https://www.uniprot.org/uniprot/P58660", "type": "external" } ], "mass": 114414.0, "length": 1021, "protein_name": "Caspase recruitment domain-containing protein 10", "gene_name": "Card10", "organism": "Mouse", "refseq_name": "caspase recruitment domain-containing protein 10", "refseq_ac": [ { "id": "NP_570929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570929", "type": "external" } ], "gene_names_uniprotkb": "Card10; Bimp1", "gene_names_refseq": "Bimp1; Card10; Carma3", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 10; Bcl10-interacting MAGUK protein 1; Bimp1", "protein_names_refseq": "bcl10-interacting MAGUK protein 1; caspase recruitment domain-containing protein 10", "tax_id": 10090, "disease": "immunodeficiency 89 (Disease Ontology:DOID:0061059)", "pathway": " (mmu:105844)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11387339;17101977;17438001;18757306;21183079;21750661;25428506;26041536;26947079;28717989;29773596;31219806;34428180;34656852;37030515", "class_list": "", "function": "CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria., [RefSeq, PubMed]; CARMA3 is critical for the initiation of allergic airway inflammation., [RefSeq, PubMed]; CARMA3 is gradually turned over following vesicular stomatitis virus infection, which may serve as a mechanism to turn off NF-kB activation, it releases MAVS to form functional aggregates to induce interferon regulatory factor 3 activation., [RefSeq, PubMed]; CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in hepatocytes., [RefSeq, PubMed]; Card10 is expressed in granulocytes and is a direct target of CEBPE with functions extending to myeloid differentiation., [RefSeq, PubMed]; Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation., [RefSeq, PubMed]; Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis., [RefSeq, PubMed]; Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Together, results provide the genetic evidence that CARMA3 is required for G protein-coupled receptor-induced NF-kappaB activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0007165 signal transduction;GO:0050776 regulation of immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P58660-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CC27-1", "uniprot_id": [ { "id": "CACB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CC27", "type": "external" } ], "mass": 73149.0, "length": 655, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-2", "gene_name": "Cacnb2", "organism": "Mouse", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-2 isoform 3", "refseq_ac": [ { "id": "NP_001296448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296448", "type": "external" } ], "gene_names_uniprotkb": "Cacnb2; Cacnlb2", "gene_names_refseq": "CAB2; Cacnb2; Cavbeta2; Cchb2", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Calcium channel voltage-dependent subunit beta 2", "protein_names_refseq": "calcium channel voltage-dependent beta 2 subunit isoform N4a; calcium channel voltage-dependent beta 2 subunit isoform N4b; voltage-dependent L-type calcium channel subunit beta-2 isoform 3; voltage-dependent L-type calcium channel subunit beta-2", "tax_id": 10090, "disease": "Brugada syndrome 4 (Disease Ontology:DOID:0110221); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:12296); (R-MMU-112308); (R-MMU-422356); (R-MMU-5576892); (R-MMU-5576893)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14674701;21183079;21750661;24751537;33602505;36424916;36738788", "class_list": "", "function": "A novel calcium channel Cavbeta2 splice variant with unique properties predominates in the retina., [RefSeq, PubMed]; Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:14674701, PubMed:36424916). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Requirement of the Ca(2+) channel beta2 subunit for sympathetic PKA phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASJ8;Q8C5J5;Q9CTQ6", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098793 presynapse;GO:1990454 L-type voltage-gated calcium channel complex;GO:0005891 voltage-gated calcium channel complex;GO:0098684 photoreceptor ribbon synapse", "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:0072659 protein localization to plasma membrane;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0086091 regulation of heart rate by cardiac conduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CC27-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U35-1", "uniprot_id": [ { "id": "ARHGH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U35", "type": "external" } ], "mass": 221671.0, "length": 2057, "protein_name": "Rho guanine nucleotide exchange factor 17", "gene_name": "Arhgef17", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 17", "refseq_ac": [ { "id": "NP_001074585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074585", "type": "external" } ], "gene_names_uniprotkb": "Arhgef17; Kiaa0337", "gene_names_refseq": "8030463K16; Arhgef17; mKIAA0337", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 17", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 17; rho guanine nucleotide exchange factor 17", "tax_id": 10090, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941)", "pathway": " (mmu:207212); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22872234;30084848;30779550;31219806;34203471;34428180;34808208;35820727;36210013", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases., [UniProtKB]; Gbetagamma mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZY4", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80U35-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ12-1", "uniprot_id": [ { "id": "AGRG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ12", "type": "external" } ], "mass": 110200.0, "length": 1009, "protein_name": "Adhesion G protein-coupled receptor G2", "gene_name": "Adgrg2", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor G2 isoform 4", "refseq_ac": [ { "id": "NP_001073317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073317", "type": "external" } ], "gene_names_uniprotkb": "Adgrg2; Gpr64; Me6", "gene_names_refseq": "Adgrg2; B830041D06Rik; Gpr64; Me6", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G2; G protein-coupled receptor 64; Me6; Mouse epididymis-specific protein 6", "protein_names_refseq": "G protein coupled receptor He6; G-protein coupled receptor 64; LNB-TM7 heptahelical receptor Me6; adhesion G-protein coupled receptor G2 isoform 4; epididymis-specific protein 6", "tax_id": 10090, "disease": "X-linked congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111863)", "pathway": " (mmu:237175)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12420295;15367682;17034053;18469038;21183079;21750661;33303626;33831593;35418677;35982227", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione (PubMed:35982227). Involved in a signal transduction pathway controlling epididymal function and male fertility (PubMed:15367682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:35982227). ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35982227). Also able to couple with G(q) G proteins in vitro (PubMed:35982227). May regulate fluid exchange within epididymis (PubMed:15367682)., [UniProtKB, PubMed, PubMed]; Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione. Involved in a signal transduction pathway controlling epididymal function and male fertility. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple with G(q) G proteins in vitro. May regulate fluid exchange within epididymis., [UniProtKB, UniProtKB]; Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells., [RefSeq, PubMed]; Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology., [RefSeq, PubMed]; The knockout of the HE6/Gpr64 receptor was mainly associated with the downregulation of genes specific to the initial segment., [RefSeq, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 17, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "A2AHP8;A2AHP9;A2AHQ0;A2AHQ3;Q8BL10;Q8CJ08;Q8CJ09;Q8CJ10", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007286 spermatid development;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8CJ12-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31750-1", "uniprot_id": [ { "id": "AKT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P31750", "type": "external" } ], "mass": 55707.0, "length": 480, "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "Akt1", "organism": "Mouse", "refseq_name": "RAC-alpha serine/threonine-protein kinase isoform 2", "refseq_ac": [ { "id": "NP_001159366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159366", "type": "external" } ], "gene_names_uniprotkb": "Akt1; Akt; Rac", "gene_names_refseq": "Akt1; Akt; LTR-akt; PKB/Akt; PKBalpha; PKB; Rac", "protein_names_uniprotkb": "RAC-alpha serine/threonine-protein kinase; 2.7.11.1; AKT1 kinase; PKB alpha; PKB; Protein kinase B alpha; Protein kinase B; Proto-oncogene c-Akt; RAC-PK-alpha; Thymoma viral proto-oncogene", "protein_names_refseq": "AKT1 kinase; Akt1m protein; PKB alpha; RAC-PK-alpha; RAC-alpha serine/threonine-protein kinase isoform 2; RAC-alpha serine/threonine-protein kinase; protein kinase B-alpha; proto-oncogene c-AKT; related to A and C kinases; thymoma viral proto-oncogene 1; tumor rejection antigen peptide pRLib", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Cowden syndrome 6 (Disease Ontology:DOID:0081002); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); esophageal carcinoma (Disease Ontology:DOID:1107); alcoholic hepatitis (Disease Ontology:DOID:12351); vulva cancer (Disease Ontology:DOID:1245); Proteus syndrome (Disease Ontology:DOID:13482); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); opiate dependence (Disease Ontology:DOID:2559); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); malignant astrocytoma (Disease Ontology:DOID:3069); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); esophageal cancer (Disease Ontology:DOID:5041); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); paraplegia (Disease Ontology:DOID:607); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:11651); (R-MMU-1257604); (R-MMU-1358803); (R-MMU-1474151); (R-MMU-165159); (R-MMU-165181); (R-MMU-198323); (R-MMU-198693); (R-MMU-199418); (R-MMU-203615); (R-MMU-211163); (R-MMU-354192); (R-MMU-3769402); (R-MMU-389357); (R-MMU-389513); (R-MMU-392451); (R-MMU-450385); (R-MMU-450604); (R-MMU-5218920); (R-MMU-5628897); (R-MMU-6804757); (R-MMU-6804758); (R-MMU-6804759); (R-MMU-6811558); (R-MMU-69202); (R-MMU-69656); (R-MMU-8849469); (R-MMU-8876198); (R-MMU-8948751); (R-MMU-9009391); (R-MMU-9604323); (R-MMU-9607240); (R-MMU-9614399); (R-MMU-9634638); (R-MMU-9755511); (R-MMU-9841251); (R-MMU-9856530)", "pathway_count": 37, "publication_count": 994, "publication_id_list": 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"class_list": "", "function": "AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:21432781, PubMed:21620960, PubMed:21954288, PubMed:26095253, PubMed:26107252, PubMed:30504268, PubMed:32350463). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21432781, PubMed:21620960, PubMed:21954288, PubMed:23684622, PubMed:26235620). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:9415393). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (PubMed:11579209). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (PubMed:22057101). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (PubMed:22057101). AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Part of a positive feedback loop of mTORC2 signaling by mediating phosphorylation of MAPKAP1/SIN1, promoting mTORC2 activation (PubMed:23684622, PubMed:26235620). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (PubMed:10454575). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1) (PubMed:11282895, PubMed:18288188). AKT mediates the antiapoptotic effects of IGF1 (PubMed:11282895). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (PubMed:12783884). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as a negative regulator of the cGAS-STING pathway by mediating phosphorylation of CGAS during mitosis, leading to its inhibition (PubMed:26440888). Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space, impairing MICU1 maturation (PubMed:30504268). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (By similarity). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 0, "mined_o_glycosites": 4, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 47, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q62274;Q6GSA6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1904263 positive regulation of TORC1 signaling;GO:1902018 negative regulation of cilium assembly;GO:0036294 cellular response to decreased oxygen levels;GO:0003376 sphingosine-1-phosphate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 100.0, "record_id": "P31750-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100010001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WPF7-1", "uniprot_id": [ { "id": "AUTS2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "type": "external" } ], "mass": 138920.0, "length": 1261, "protein_name": "Autism susceptibility gene 2 protein homolog", "gene_name": "Auts2", "organism": "Mouse", "refseq_name": "autism susceptibility gene 2 protein homolog", "refseq_ac": [ { "id": "NP_001350409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001350409", "type": "external" } ], "gene_names_uniprotkb": "Auts2; Kiaa0442", "gene_names_refseq": "2700063G02Rik; A730011F23Rik; Auts2; D830032G16Rik", "protein_names_uniprotkb": "Autism susceptibility gene 2 protein homolog", "protein_names_refseq": "autism susceptibility gene 2 protein homolog", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autosomal dominant intellectual developmental disorder (Disease Ontology:DOID:0060307); autosomal dominant intellectual developmental disorder 26 (Disease Ontology:DOID:0070056); microcephaly (Disease Ontology:DOID:10907); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:319974); (R-MMU-8939243)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19948250;21750661;25519132;25533347;34203471;34428180;36525998", "class_list": "", "function": "Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology., [RefSeq, PubMed]; Auts2 regulated autism-like behavior, glucose metabolism and oxidative stress in mice., [RefSeq, PubMed]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation (By similarity). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9PWJ4;Q6ZQB3;Q8BWI6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0030426 growth cone;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration;GO:0030036 actin cytoskeleton organization;GO:0060013 righting reflex", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A0A087WPF7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLZ3-1", "uniprot_id": [ { "id": "AUHM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLZ3", "type": "external" } ], "mass": 33395.0, "length": 314, "protein_name": "Methylglutaconyl-CoA hydratase, mitochondrial", "gene_name": "Auh", "organism": "Mouse", "refseq_name": "methylglutaconyl-CoA hydratase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_057918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057918", "type": "external" } ], "gene_names_uniprotkb": "Auh", "gene_names_refseq": "Auh", "protein_names_uniprotkb": "Methylglutaconyl-CoA hydratase, mitochondrial; 3-MG-CoA hydratase; 4.2.1.18; 4.2.1.56; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; Itaconyl-CoA hydratase; muAUH", "protein_names_refseq": "3-MG-CoA hydratase; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; itaconyl-CoA hydratase; methylglutaconyl-CoA hydratase, mitochondrial isoform 1; methylglutaconyl-CoA hydratase, mitochondrial; muAUH", "tax_id": 10090, "disease": "3-methylglutaconic aciduria type 1 (Disease Ontology:DOID:0110002); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (mmu:11992); (R-MMU-70895)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10072761;21750661;23576753;23806337;31219806;36288343;37507081", "class_list": "", "function": "Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Can catalyze the reverse reaction but at a much lower rate in vitro. HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate. Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) (By similarity). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro. AREs direct rapid RNA degradation and mRNA deadenylation (PubMed:10072761). Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YD7;Q8QZS0;Q9CY78;Q9D155", "ec_number_list": [ { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "4.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.18", "type": "external" }, { "id": "4.2.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.56", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0004300 enoyl-CoA hydratase activity;GO:0004490 methylglutaconyl-CoA hydratase activity;GO:0050011 itaconyl-CoA hydratase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JLZ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V94-1", "uniprot_id": [ { "id": "AP4E1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V94", "type": "external" } ], "mass": 124845.0, "length": 1122, "protein_name": "AP-4 complex subunit epsilon-1", "gene_name": "Ap4e1", "organism": "Mouse", "refseq_name": "AP-4 complex subunit epsilon-1", "refseq_ac": [ { "id": "NP_780759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780759", "type": "external" } ], "gene_names_uniprotkb": "Ap4e1", "gene_names_refseq": "2310033A20Rik; 9930028M04Rik; Ap4e1", "protein_names_uniprotkb": "AP-4 complex subunit epsilon-1; AP-4 adaptor complex subunit epsilon; Adaptor-related protein complex 4 subunit epsilon-1; Epsilon subunit of AP-4; Epsilon-adaptin", "protein_names_refseq": "AP-4 adapter complex subunit epsilon; AP-4 adaptor complex subunit epsilon; AP-4 complex subunit epsilon-1; adapter-related protein complex 4 subunit epsilon-1; adaptor-related protein complex 4 subunit epsilon-1; epsilon subunit of AP-4; epsilon-adaptin", "tax_id": 10090, "disease": "stuttering (Disease Ontology:DOID:0060243); hereditary spastic paraplegia 51 (Disease Ontology:DOID:0110803)", "pathway": " (mmu:108011); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "18341993;21750661;25428506;30084848;31219806;31599954;34428180;35822049;38281682", "class_list": "", "function": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal., [UniProtKB, UniProtKB]; The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for Hereditary Spastic Paraplegia. Erratum:[Prog Neurobiol. 2024 Oct;241:102662. doi: 10.1016/j.pneurobio.2024.102662. PMID: 39294072], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ASB4", "ec_number_list": [], "go_molecular_function": "GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0030124 AP-4 adaptor complex;GO:0012505 endomembrane system;GO:0030117 membrane coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80V94-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FE2-1", "uniprot_id": [ { "id": "ATG9A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FE2", "type": "external" } ], "mass": 94425.0, "length": 839, "protein_name": "Autophagy-related protein 9A", "gene_name": "Atg9a", "organism": "Mouse", "refseq_name": "autophagy-related protein 9A isoform a", "refseq_ac": [ { "id": "NP_001003917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003917", "type": "external" } ], "gene_names_uniprotkb": "Atg9a; Apg9l1", "gene_names_refseq": "Apg9l1; Atg9a; Atg9l1; Atg9", "protein_names_uniprotkb": "Autophagy-related protein 9A; APG9-like 1", "protein_names_refseq": "APG9 autophagy 9-like 1; APG9-like 1; autophagy protein 9; autophagy-related 9-like 1; autophagy-related protein 9A isoform a; autophagy-related protein 9A", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:245860); (R-MMU-1632852); (R-MMU-5205685)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;15755735;19144319;19926846;20124090;21183079;21750661;23402761;26370455;27587839;27811852;27934868;28513333;30084848;37086384;37266953;37723445;38373380", "class_list": "", "function": "A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila. Publication Status: Online-Only, [RefSeq, PubMed]; Atg9Ap may be involved in autophagosome formation in the ER and axon terminals of neurons, the TGN, and lysosomes/late endosomes., [RefSeq, PubMed]; HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation., [RefSeq, PubMed]; IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress., [RefSeq, PubMed]; Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:23402761, PubMed:27587839). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (By similarity). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (By similarity). In addition to autophagy, also plays a role in necrotic cell death (PubMed:27811852)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by beta1-adrenoceptor autoantibodies. Publication Status: Online-Only, [RefSeq, PubMed]; STING co-localizes with the autophagy proteins, microtubule-associated protein 1 light chain 3 (LC3) and autophagy-related gene 9a (Atg9a), after dsDNA stimulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAQ4", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0060349 bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q68FE2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSN3-1", "uniprot_id": [ { "id": "ODAD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSN3", "type": "external" } ], "mass": 69713.0, "length": 593, "protein_name": "Outer dynein arm-docking complex subunit 3", "gene_name": "ODAD3; Odad3", "organism": "Mouse", "refseq_name": "outer dynein arm-docking complex subunit 3 isoform 1", "refseq_ac": [ { "id": "NP_001157259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157259", "type": "external" } ], "gene_names_uniprotkb": "ODAD3; Odad3; Ccdc151", "gene_names_refseq": "C330001K17Rik; Ccdc151; Odad3; b2b1885Clo", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 3; Coiled-coil domain-containing protein 151", "protein_names_refseq": "coiled-coil domain containing 151; coiled-coil domain-containing protein 151; outer dynein arm-docking complex subunit 3 isoform 1", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 30 (Disease Ontology:DOID:0110624); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:77609)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;21750661;24067530;25192045;31383820;35820727", "class_list": "", "function": "C330001K17Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Ccdc151 expression is strongly induced during in vitro differentiation of motile cilia of ependymal cells., [RefSeq, PubMed]; Ccdc151 gene deletion in adult animals results in abnormal sperm counts and defective sperm motility. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). May be required for motile cilia function (PubMed:24067530)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X951;Q6PGE8;Q9CWC6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0035253 ciliary rootlet;GO:0005814 centriole;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902017 regulation of cilium assembly;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BSN3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2A5-1", "uniprot_id": [ { "id": "ATE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2A5", "type": "external" } ], "mass": 59146.0, "length": 516, "protein_name": "Arginyl-tRNA--protein transferase 1", "gene_name": "Ate1", "organism": "Mouse", "refseq_name": "arginyl-tRNA--protein transferase 1 isoform 1", "refseq_ac": [ { "id": "NP_038827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038827", "type": "external" } ], "gene_names_uniprotkb": "Ate1", "gene_names_refseq": "Ate1", "protein_names_uniprotkb": "Arginyl-tRNA--protein transferase 1; 2.3.2.8; Arginine-tRNA--protein transferase 1; Arginyltransferase 1; R-transferase 1", "protein_names_refseq": "R-transferase 1; arginine-tRNA--protein transferase 1; arginyl-tRNA--protein transferase 1 isoform 1; arginyl-tRNA--protein transferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11907)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12098698;16002466;21750661;25369936;25428506;30084848;30779550;34203471;34428180;34893540;34896361;37507081;9858543", "class_list": "", "function": "Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Role in cardiovascular development, [RefSeq, PubMed]; The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FCQ6;Q4FCQ7;Q8CFP7;Q9Z2A4", "ec_number_list": [ { "id": "2.3.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.8", "type": "external" } ], "go_molecular_function": "GO:0004057 arginyl-tRNA--protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0010498 proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070534 protein K63-linked ubiquitination;GO:0016598 protein arginylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z2A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70343-1", "uniprot_id": [ { "id": "CASP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P70343", "type": "external" } ], "mass": 42742.0, "length": 373, "protein_name": "Caspase-4", "gene_name": "Casp4", "organism": "Mouse", "refseq_name": "caspase-4 isoform 1", "refseq_ac": [ { "id": "NP_031635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031635", "type": "external" } ], "gene_names_uniprotkb": "Casp4; Casp11; Caspl; Ich3", "gene_names_refseq": "CASP-11; CASP-4; Casp11; Casp4; Caspl; ich-3", "protein_names_uniprotkb": "Caspase-4; 3.4.22.64; CASP-11; CASP-4; Caspase-11; Protease ICH-3", "protein_names_refseq": "caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; caspase-11 short form splicing; caspase-4 isoform 1; caspase-4; protease ICH-3", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:12363); (R-MMU-168638); (R-MMU-5620971); (R-MMU-9948001); (R-MMU-9948011); (R-MMU-9960519); (R-MMU-9960525)", "pathway_count": 7, "publication_count": 34, "publication_id_list": "10986288;16670335;21750661;22002608;22895188;23348507;23887873;24031018;25119034;25121752;26173909;26320999;26375003;26375259;27103670;28314590;29520027;30135078;30392956;30589883;30692621;31219806;32109412;32554464;33723046;34428180;34671164;36210013;37001519;37993712;37993714;38632402;8702803;9038361", "class_list": "", "function": "Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:22002608, PubMed:23348507, PubMed:23887873, PubMed:24031018, PubMed:25119034, PubMed:30135078, PubMed:37001519, PubMed:38632402). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:26320999, PubMed:30392956, PubMed:37001519). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS and GSDMD (PubMed:26375003, PubMed:28314590, PubMed:30392956, PubMed:38632402). In contrast to its human ortholog, does not cleave IL18 (PubMed:37993712, PubMed:37993714). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B and IL18 (PubMed:22002608, PubMed:22895188, PubMed:23348507, PubMed:23887873, PubMed:24031018, PubMed:26320999, PubMed:26375003, PubMed:30135078, PubMed:30589883). In the non-canonical inflammasome, CASP4/CASP11 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:22002608, PubMed:23348507, PubMed:25119034, PubMed:37001519, PubMed:38632402). LPS-binding promotes CASP4/CASP11 activation and CASP4/CASP11-mediated cleavage of GSDMD, followed by pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:22002608, PubMed:23348507, PubMed:25119034, PubMed:38632402). Also indirectly promotes secretion of mature cytokines (IL1A, IL18 and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (By similarity). Involved in NLRP3-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:26320999). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B and IL18 secretion (PubMed:30392956). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (By similarity). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (PubMed:23348507). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:26375003, PubMed:34671164). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (PubMed:38632402). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (PubMed:27103670). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4/CASP11 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412, PubMed:32554464). In contrast, it does not directly process IL1B (PubMed:8702803, PubMed:9038361). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is 'caspase 4, apoptosis-related cysteine peptidase', this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6L648;O08735;Q3TAF3;Q6P8H1", "ec_number_list": [ { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "3.4.22.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.64", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" } ], "go_molecular_function": "GO:0008289 lipid binding;GO:0097110 scaffold protein binding;GO:0001530 lipopolysaccharide binding;GO:0004197 cysteine-type endopeptidase activity;GO:0050700 CARD domain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0007015 actin filament organization;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0050727 regulation of inflammatory response;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P70343-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9R4-4", "uniprot_id": [ { "id": "ARHGI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9R4", "type": "external" } ], "mass": 155982.0, "length": 1405, "protein_name": "Rho guanine nucleotide exchange factor 18", "gene_name": "Arhgef18", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 18 isoform 2", "refseq_ac": [ { "id": "NP_598723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598723", "type": "external" } ], "gene_names_uniprotkb": "Arhgef18; Kiaa0521", "gene_names_refseq": "A430078G23Rik; Arhgef18; D030053O22Rik", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 18", "protein_names_refseq": "rho guanine nucleotide exchange factor 18 isoform 2; rho guanine nucleotide exchange factor 18; rho/rac guanine nucleotide exchange factor (GEF) 18", "tax_id": 10090, "disease": "retinitis pigmentosa 78 (Disease Ontology:DOID:0061113)", "pathway": " (mmu:102098); (R-MMU-193648); (R-MMU-2173791); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013149)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22872234;29601110;31219806;34203471;34428180", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G protein-coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QK59;Q6A055;Q8BYA4;Q8K227", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0030036 actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P9R4-4", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVM3-1", "uniprot_id": [ { "id": "APC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVM3", "type": "external" } ], "mass": 63021.0, "length": 565, "protein_name": "Anaphase-promoting complex subunit 7", "gene_name": "Anapc7", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 7", "refseq_ac": [ { "id": "NP_062779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062779", "type": "external" } ], "gene_names_uniprotkb": "Anapc7; Apc7", "gene_names_refseq": "APC7; Anapc7", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 7; APC7; Cyclosome subunit 7; Prediabetic NOD sera-reactive autoantigen", "protein_names_refseq": "anaphase-promoting complex subunit 7; cyclosome subunit 7; prediabetic NOD sera-reactive autoantigen", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:56317); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10515598;21750661;22872234;23806337;31219806;33300544;34942119", "class_list": "", "function": "APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain., [RefSeq, PubMed]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (PubMed:34942119). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBM7;Q8BSR2;Q91W13", "ec_number_list": [], "go_molecular_function": "GO:0019903 protein phosphatase binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0051301 cell division;GO:0007420 brain development;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WVM3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14AT5-1", "uniprot_id": [ { "id": "ANO7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14AT5", "type": "external" } ], "mass": 97128.0, "length": 859, "protein_name": "Anoctamin-7", "gene_name": "Ano7", "organism": "Mouse", "refseq_name": "anoctamin-7 isoform 2", "refseq_ac": [ { "id": "NP_001258813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258813", "type": "external" } ], "gene_names_uniprotkb": "Ano7; Ngep; Tmem16g", "gene_names_refseq": "Ano7; Ngep-L; Ngep; Pcanap5; Tmem16g", "protein_names_uniprotkb": "Anoctamin-7; New gene expressed in prostate homolog; Transmembrane protein 16G", "protein_names_refseq": "anoctamin-7 isoform 2; prostate cancer associated protein 5; transmembrane protein 16g", "tax_id": 10090, "disease": "", "pathway": " (mmu:404545); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14981236;20056604;21750661;22302790;23532839;30084848;31599954", "class_list": "", "function": "Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). May play a role in cell-cell interactions (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6IFT5", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0061589 calcium activated phosphatidylserine scrambling;GO:0061590 calcium activated phosphatidylcholine scrambling;GO:0061591 calcium activated galactosylceramide scrambling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q14AT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3X6-1", "uniprot_id": [ { "id": "ANS4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3X6", "type": "external" } ], "mass": 47975.0, "length": 423, "protein_name": "Ankyrin repeat and SAM domain-containing protein 4B", "gene_name": "Anks4b", "organism": "Mouse", "refseq_name": "ankyrin repeat and SAM domain-containing protein 4B", "refseq_ac": [ { "id": "NP_082361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082361", "type": "external" } ], "gene_names_uniprotkb": "Anks4b; Harp", "gene_names_refseq": "2010013E14Rik; Anks4b; Harp", "protein_names_uniprotkb": "Ankyrin repeat and SAM domain-containing protein 4B; Harmonin-interacting ankyrin repeat-containing protein; Harp", "protein_names_refseq": "ankyrin repeat and SAM domain-containing protein 4B; harmonin-interacting ankyrin repeat-containing protein; harmonin-interacting ankyrin-repeat containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:72074)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15461667;17242355;22589549;26812017;26812018;30084848;34428180", "class_list": "", "function": "Anks4b is a HNF4alpha target gene that regulates endoplasmic reticulum stress in beta-cells by interacting with GRP78, thus suggesting that HNF4alpha is involved in maintenance of the ER., [RefSeq, PubMed]; As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (By similarity). May play a role in cellular response to endoplasmic reticulum stress (PubMed:22589549)., [UniProtKB, UniProtKB, PubMed]; Harp + harmonin constitute a scaffolding complex to facilitate signal transduction in epithelia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148R3;Q9D8A5", "ec_number_list": [], "go_molecular_function": "GO:0017022 myosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005789 endoplasmic reticulum membrane;GO:0005902 microvillus;GO:0002141 stereocilia ankle link", "go_biological_process": "GO:0030154 cell differentiation;GO:0034976 response to endoplasmic reticulum stress;GO:1904106 protein localization to microvillus;GO:1904970 brush border assembly;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K3X6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6Z0-1", "uniprot_id": [ { "id": "ALKB7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6Z0", "type": "external" } ], "mass": 24970.0, "length": 221, "protein_name": "RNA demethylase ALKBH7, mitochondrial", "gene_name": "Alkbh7", "organism": "Mouse", "refseq_name": "RNA demethylase ALKBH7, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_079814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079814", "type": "external" } ], "gene_names_uniprotkb": "Alkbh7; Spata11", "gene_names_refseq": "2310045B01Rik; 2510008E23Rik; Abh7; Alkbh7; Spata11", "protein_names_uniprotkb": "RNA demethylase ALKBH7, mitochondrial; 1.14.11.-; Alkylated DNA repair protein alkB homolog 7; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial", "protein_names_refseq": "RNA demethylase ALKBH7, mitochondrial isoform 1 precursor; RNA demethylase ALKBH7, mitochondrial; alkB, alkylation repair homolog 7; alkylated DNA repair protein alkB homolog 7; alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; probable alpha-ketoglutarate-dependent dioxygenase ABH7; spermatogenesis associated 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:66400)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23572141;28726787;32795389", "class_list": "", "function": "ALKBH7 mediates necrosis via rewiring of glyoxal metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity (By similarity). In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (By similarity). Involved in fatty acid metabolism (PubMed:23572141)., [UniProtKB, UniProtKB, PubMed]; Results uncover an in vivo role for ALKBH7 in mediating a sexually dimorphic tissue response to alkylation damage that could influence individual responses to chemotherapies based upon alkylating agents. Publication Status: Online-Only, [RefSeq, PubMed]; The first direct demonstration that murine Alkbh7 is a mitochondrial resident protein involved in fatty acid metabolism and the development of obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1H3;Q9CY41;Q9D942", "ec_number_list": [ { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:1990984 tRNA demethylase activity;GO:0035515 oxidative RNA demethylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006974 DNA damage response;GO:0010883 regulation of lipid storage;GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:0035513 oxidative RNA demethylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48036-1", "uniprot_id": [ { "id": "ANXA5_MOUSE", "url": "https://www.uniprot.org/uniprot/P48036", "type": "external" } ], "mass": 35752.0, "length": 319, "protein_name": "Annexin A5", "gene_name": "Anxa5", "organism": "Mouse", "refseq_name": "annexin A5", "refseq_ac": [ { "id": "NP_033803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033803", "type": "external" } ], "gene_names_uniprotkb": "Anxa5; Anx5", "gene_names_refseq": "Anx5; Anxa5; CPB-I", "protein_names_uniprotkb": "Annexin A5; Anchorin CII; Annexin V; Annexin-5; CPB-I; Calphobindin I; Endonexin II; Lipocortin V; PAP-I; PP4; Placental anticoagulant protein 4; Placental anticoagulant protein I; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha", "protein_names_refseq": "CBP-I; PAP-I; PP4; VAC-alpha; anchorin CII; annexin A5; annexin V; annexin-5; calphobindin I; endonexin II; lipocortin V; placental anticoagulant protein 4; placental anticoagulant protein I; thromboplastin inhibitor; vascular anticoagulant-alpha", "tax_id": 10090, "disease": "nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); cryptorchidism (Disease Ontology:DOID:11383); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); glomerulonephritis (Disease Ontology:DOID:2921); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); systemic scleroderma (Disease Ontology:DOID:418); autoimmune disease of the nervous system (Disease Ontology:DOID:438); myocardial infarction (Disease Ontology:DOID:5844); hyperthyroidism (Disease Ontology:DOID:7998); Wilson disease (Disease Ontology:DOID:893)", "pathway": " (mmu:11747); (R-MMU-114608)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "21183079;21750661;23806337;26740625;34418053;34428180;36288343;36700781;37453647;37507081;37828378;8824796;9854034", "class_list": "glycogene", "function": "Annexin A5 ameliorates traumatic brain injury-induced neuroinflammation and neuronal ferroptosis by modulating the NF-kB/HMGB1 and Nrf2/HO-1 pathways., [RefSeq, PubMed]; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5Q1;Q3U5X4;Q3U8K1;Q3UGV0;Q99LA1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0017046 peptide hormone binding;GO:0030971 receptor tyrosine kinase binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0007596 blood coagulation;GO:0030195 negative regulation of blood coagulation;GO:0097211 cellular response to gonadotropin-releasing hormone", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P48036-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17427-1", "uniprot_id": [ { "id": "AP2A2_MOUSE", "url": "https://www.uniprot.org/uniprot/P17427", "type": "external" } ], "mass": 104017.0, "length": 938, "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "Ap2a2", "organism": "Mouse", "refseq_name": "AP-2 complex subunit alpha-2 isoform 2", "refseq_ac": [ { "id": "NP_031485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031485", "type": "external" } ], "gene_names_uniprotkb": "Ap2a2; Adtab", "gene_names_refseq": "2410074K14Rik; Adtab; Ap2a2; L25", "protein_names_uniprotkb": "AP-2 complex subunit alpha-2; 100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; Clathrin assembly protein complex 2 alpha-C large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit", "protein_names_refseq": "100 kDa coated vesicle protein C; AP-2 complex subunit alpha-2 isoform 2; AP-2 complex subunit alpha-2; adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptor protein complex AP-2 subunit alpha-2; adaptor protein complex AP-2, alpha 2 subunit; adaptor-related protein complex 2 subunit alpha-2; adaptor-related protein complex AP-2, alpha 2 subunit; alpha-C adaptin; alpha-adaptin C; alpha2-adaptin; clathrin assembly protein complex 2 alpha-C large chain; plasma membrane adaptor HA2/AP2 adaptin alpha C subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:11772); (R-MMU-177504); (R-MMU-2132295); (R-MMU-416993); (R-MMU-437239); (R-MMU-5099900); (R-MMU-5140745); (R-MMU-6798695); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8866427); (R-MMU-8964038)", "pathway_count": 12, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;10380931;10430869;10459011;11247302;11470803;12057195;14530274;14745134;15473838;17035303;17880279;19140243;20154091;21750661;21952136;22484487;22645316;23676497;24097348;2564002;29262337;29288152;31219806;33300544;34428180;34887587;37453647;9618202", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2J5;Q921V0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0030141 secretory granule;GO:0045202 synapse;GO:0031410 cytoplasmic vesicle;GO:0098794 postsynapse;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006886 intracellular protein transport;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0016192 vesicle-mediated transport;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P17427-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4J9-1", "uniprot_id": [ { "id": "AGRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4J9", "type": "external" } ], "mass": 71764.0, "length": 644, "protein_name": "Adhesion G protein-coupled receptor F2", "gene_name": "Adgrf2", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor F2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001028665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028665", "type": "external" } ], "gene_names_uniprotkb": "Adgrf2; Gpr111; Pgr20", "gene_names_refseq": "Adgrf2; Gpr111; PGR20", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F2; G protein-coupled receptor 111; G protein-coupled receptor PGR20", "protein_names_refseq": "G protein coupled receptor Gpr111; G protein-coupled receptor 111; G protein-coupled receptor PGR20; adhesion G-protein coupled receptor F2 isoform 2 precursor; probable G-protein coupled receptor 111", "tax_id": 10090, "disease": "", "pathway": " (mmu:435529)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22837050;33300544;35820727;36929047", "class_list": "", "function": "Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process., [RefSeq, PubMed]; Orphan receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ67", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009268 response to pH;GO:0034505 tooth mineralization;GO:0070166 enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "E9Q4J9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54754-1", "uniprot_id": [ { "id": "AOXA_MOUSE", "url": "https://www.uniprot.org/uniprot/O54754", "type": "external" } ], "mass": 146678.0, "length": 1333, "protein_name": "Aldehyde oxidase 1", "gene_name": "Aox1", "organism": "Mouse", "refseq_name": "aldehyde oxidase 1", "refseq_ac": [ { "id": "NP_033806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033806", "type": "external" } ], "gene_names_uniprotkb": "Aox1; Ao; Ro", "gene_names_refseq": "Aox-1; Aox-2; Aox1; Aox2; Ao; Moro; Ro", "protein_names_uniprotkb": "Aldehyde oxidase 1; 1.17.3.-; 1.2.3.1; Azaheterocycle hydroxylase 1; Retinal oxidase", "protein_names_refseq": "aldehyde oxidase 1; aldehyde oxidase 2; azaheterocycle hydroxylase 1; retinal oxidase", "tax_id": 10090, "disease": "xanthinuria (Disease Ontology:DOID:0060236); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:11761); (R-MMU-964975)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10190983;10377246;10673024;18671973;19401776;21750661;21952136;23263164;23462233;24996175;25287365;25428506;25428507;30084848;30779550;34428180;34887587;35820727;9243637", "class_list": "", "function": "Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1., [RefSeq, PubMed]; Findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2, [RefSeq, PubMed]; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use xanthine and hypoxanthine as substrate., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WU85;Q9Z2Z5", "ec_number_list": [ { "id": "1.17.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.3.-", "type": "external" }, { "id": "1.2.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0016604 nuclear body", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006629 lipid metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O54754-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35841-1", "uniprot_id": [ { "id": "API5_MOUSE", "url": "https://www.uniprot.org/uniprot/O35841", "type": "external" } ], "mass": 56785.0, "length": 504, "protein_name": "Apoptosis inhibitor 5", "gene_name": "Api5", "organism": "Mouse", "refseq_name": "apoptosis inhibitor 5 isoform 2", "refseq_ac": [ { "id": "NP_031492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031492", "type": "external" } ], "gene_names_uniprotkb": "Api5", "gene_names_refseq": "AAC-11; API-5; Api5", "protein_names_uniprotkb": "Apoptosis inhibitor 5; AAC-11; API-5", "protein_names_refseq": "apoptosis inhibitor 5 isoform 2; apoptosis inhibitory protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:11800)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19144319;21183079;25428506;29187734;30084848;30899004;31219806;34428180;36198790;9307294;9918813", "class_list": "", "function": "Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity)., [UniProtKB]; The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U517;Q922L2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:2000270 negative regulation of fibroblast apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O35841-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10107-1", "uniprot_id": [ { "id": "ANXA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P10107", "type": "external" } ], "mass": 38734.0, "length": 346, "protein_name": "Annexin A1", "gene_name": "Anxa1", "organism": "Mouse", "refseq_name": "annexin A1", "refseq_ac": [ { "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860", "type": "external" } ], "gene_names_uniprotkb": "Anxa1; Anx1; Lpc-1; Lpc1", "gene_names_refseq": "Anx-1; Anx-A1; Anxa1; C430014K04Rik; Lpc-1; Lpc1", "protein_names_uniprotkb": "Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35", "protein_names_refseq": "annexin A1; annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; p35; phospholipase A2 inhibitory protein", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); dry eye syndrome (Disease Ontology:DOID:10140); pleurisy (Disease Ontology:DOID:10247); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); uveitis (Disease Ontology:DOID:13141); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); hypothyroidism (Disease Ontology:DOID:1459); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); keratosis follicularis (Disease Ontology:DOID:2734); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); malignant astrocytoma (Disease Ontology:DOID:3069); ischemia (Disease Ontology:DOID:326); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); renal cell carcinoma (Disease Ontology:DOID:4450); seborrheic keratosis (Disease Ontology:DOID:6498); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:16952); (R-MMU-416476); (R-MMU-418594); (R-MMU-444473)", "pathway_count": 4, "publication_count": 36, "publication_id_list": "11482905;12475898;14506282;16720734;1676980;17384087;17948261;18250455;18641677;18802107;19104500;19131326;21245195;21540332;21750661;22645316;23727357;23806337;24788674;25153642;2522299;25605945;25664854;26516201;26803520;27426034;27802388;2974946;31219806;32133417;34428180;36288343;37507081;37828378;38358087;39927985", "class_list": "", "function": "Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging., [RefSeq, PubMed]; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:12475898). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (PubMed:12475898). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells (PubMed:17948261). Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17948261). Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes (PubMed:21245195). Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (PubMed:21245195). In the context of antitumor immunity, interacts with FPR1 on dendritic cells allowing for tumor-associated antigens uptake and cross-presentation to T cells to mount an antitumor specific T cell response., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P10107-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1L8-1", "uniprot_id": [ { "id": "ANGL8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1L8", "type": "external" } ], "mass": 22063.0, "length": 198, "protein_name": "Angiopoietin-like protein 8", "gene_name": "Angptl8", "organism": "Mouse", "refseq_name": "angiopoietin-like protein 8 precursor", "refseq_ac": [ { "id": "NP_001074409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074409", "type": "external" } ], "gene_names_uniprotkb": "Angptl8; Gm6484; Rifl", "gene_names_refseq": "Angptl8; EG624219; Gm6484; Rifl", "protein_names_uniprotkb": "Angiopoietin-like protein 8; Betatrophin; Lipasin; Refeeding-induced fat and liver protein", "protein_names_refseq": "angiopoietin-like protein 8 precursor; angiopoietin-like protein 8; betatrophin; hepatocellular carcinoma-associated protein TD26 homolog; lipasin; refeeding-induced fat and liver protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:624219); (R-MMU-8963889)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "20562862;22569073;22809513;23150577;23261442;23623304;24043787;24353178;25417115;38211696;38272177;39019343;39095838", "class_list": "", "function": "ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation., [RefSeq, PubMed]; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577, PubMed:24043787). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (PubMed:24043787). According to a report, may act by promoting ANGPTL3 cleavage (PubMed:23150577). According to another study, not required for cleavage of ANGPTL3 (PubMed:24043787)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Lipasin is thus a novel nutritionally-regulated liver-enriched factor that plays a role in lipid metabolism., [RefSeq, PubMed]; Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis., [RefSeq, PubMed]; RIFL is an important new regulator of lipid metabolism., [RefSeq, PubMed]; Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling., [RefSeq, PubMed]; These results suggest Lipasin and some ANGPTLs play distinct physiological roles in mediating thermogenesis and energy homeostasis. GeneRIF: Lipasin is a novel but atypical member of the angiopoietin-like protein family., [RefSeq, PubMed]; Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0010954 positive regulation of protein processing;GO:0045444 fat cell differentiation;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R1L8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3J8-1", "uniprot_id": [ { "id": "AMTN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3J8", "type": "external" } ], "mass": 22119.0, "length": 213, "protein_name": "Amelotin", "gene_name": "Amtn", "organism": "Mouse", "refseq_name": "amelotin precursor", "refseq_ac": [ { "id": "NP_082069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082069", "type": "external" } ], "gene_names_uniprotkb": "Amtn", "gene_names_refseq": "5430427O21Rik; Amtn", "protein_names_uniprotkb": "Amelotin", "protein_names_refseq": "amelotin precursor", "tax_id": 10090, "disease": "amelogenesis imperfecta type 3B (Disease Ontology:DOID:0080243)", "pathway": " (mmu:71421); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16304441;16787391;19351503;25407797;30158339", "class_list": "", "function": "Data show that the anti-Amelotin antibody from the rabbit with high titer and specificity had been prepared with the purified recombinant Amelotin as immunogen, which is helpful for further research into the detection and function of Amelotin., [RefSeq, PubMed]; IL-1beta and TNF-alpha increase AMTN gene transcription via the C/EBP1, C/EBP2 and YY1 elements in the mouse AMTN gene promoter., [RefSeq, PubMed]; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005911 cell-cell junction;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042475 odontogenesis of dentin-containing tooth;GO:0070166 enamel mineralization;GO:0070169 positive regulation of biomineral tissue development;GO:0070175 positive regulation of enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D3J8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPJ9-1", "uniprot_id": [ { "id": "ARFG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPJ9", "type": "external" } ], "mass": 45288.0, "length": 414, "protein_name": "ADP-ribosylation factor GTPase-activating protein 1", "gene_name": "Arfgap1", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 1 isoform b", "refseq_ac": [ { "id": "NP_001171177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171177", "type": "external" } ], "gene_names_uniprotkb": "Arfgap1; Arf1gap", "gene_names_refseq": "Arf1gap; Arfgap1", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 1; ADP-ribosylation factor 1 GTPase-activating protein; ARF GAP 1; ARF1 GAP; ARF1-directed GTPase-activating protein", "protein_names_refseq": "ADP-ribosylation factor 1 GTPase activating protein; ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase-activating protein 1 isoform b; ARF GAP 1; ARF1 GAP; ARF1-directed GTPase-activating protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:228998); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12376537;17242355;21183079;21750661;28528544;29240824;31599954;32848054", "class_list": "", "function": "Data suggest that ArfGAP1 can be used as a specific marker of the dentate mossy fibers and as for visualization of cortical layers in immunohistochemical studies Publication Status: Online-Only, [RefSeq, PubMed]; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8WIR9;A8WIS1;Q3TI52;Q8BMM6;Q8BMQ7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density;GO:0031965 nuclear membrane;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EPJ9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59017-1", "uniprot_id": [ { "id": "B2L13_MOUSE", "url": "https://www.uniprot.org/uniprot/P59017", "type": "external" } ], "mass": 46719.0, "length": 434, "protein_name": "Bcl-2-like protein 13", "gene_name": "Bcl2l13", "organism": "Mouse", "refseq_name": "bcl-2-like protein 13", "refseq_ac": [ { "id": "NP_705736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705736", "type": "external" } ], "gene_names_uniprotkb": "Bcl2l13; Mil1", "gene_names_refseq": "BCL-RAMBO; Bcl2l13; E430016C20Rik; Mil-1; Mil1", "protein_names_uniprotkb": "Bcl-2-like protein 13; Bcl-rambo; Bcl2-L-13; Protein Mil1", "protein_names_refseq": "BCL2-like 13 (apoptosis facilitator); bcl-2-like protein 13; bcl2-L-13; mitochondria located 1 homolog; protein Mil1", "tax_id": 10090, "disease": "", "pathway": " (mmu:94044)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17208939;19131326;21183079;21750661;25428506;33724167;34428180;36288343;36608143;37507081;38605443", "class_list": "", "function": "A role for BCL2L13 and autophagy in germline purifying selection of mtDNA. Publication Status: Online-Only, [RefSeq, PubMed]; By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice., [RefSeq, PubMed]; CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia-reperfusion injury via miR-1246/PEG3 signaling., [RefSeq, PubMed]; May promote the activation of caspase-3 and apoptosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q543S1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0006915 apoptotic process;GO:0045444 fat cell differentiation;GO:0042981 regulation of apoptotic process;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P59017-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54827-1", "uniprot_id": [ { "id": "AT10A_MOUSE", "url": "https://www.uniprot.org/uniprot/O54827", "type": "external" } ], "mass": 168788.0, "length": 1508, "protein_name": "Phospholipid-transporting ATPase VA", "gene_name": "Atp10a", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase VA", "refseq_ac": [ { "id": "NP_033858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033858", "type": "external" } ], "gene_names_uniprotkb": "Atp10a; Atpc5; Pfatp", "gene_names_refseq": "Atp10a; Atp10c; pfatp", "protein_names_uniprotkb": "Phospholipid-transporting ATPase VA; 7.6.2.1; ATPase class V type 10A; P-locus fat-associated ATPase; P4-ATPase flippase complex alpha subunit ATP10A", "protein_names_refseq": "ATPase 10A, class V; ATPase, class 5; P-locus fat-associated ATPase; P4-ATPase flippase complex alpha subunit ATP10A; phospholipid-transporting ATPase VA; probable phospholipid-transporting ATPase VA", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:11982); (R-MMU-936837)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11015572;11074018;12105293;21183079;21750661;31616917;34428180;38172157;9548971", "class_list": "", "function": "Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer)., [UniProtKB, UniProtKB]; Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice. Publication Status: Online-Only, [RefSeq, PubMed]; Report the generation of the complete genomic structure, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3B8", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:1990531 phospholipid-translocating ATPase complex;GO:0016020 membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:1903527 positive regulation of membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O54827-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62415-1", "uniprot_id": [ { "id": "ASPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62415", "type": "external" } ], "mass": 119170.0, "length": 1087, "protein_name": "Apoptosis-stimulating of p53 protein 1", "gene_name": "Ppp1r13b", "organism": "Mouse", "refseq_name": "apoptosis-stimulating of p53 protein 1", "refseq_ac": [ { "id": "NP_035755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035755", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r13b; Aspp1", "gene_names_refseq": "ASPP1; Ppp1r13b; Tp53bp2; Trp53bp2; p85", "protein_names_uniprotkb": "Apoptosis-stimulating of p53 protein 1; Protein phosphatase 1 regulatory subunit 13B", "protein_names_refseq": "apoptosis-stimulating of p53 protein 1; protein phosphatase 1, regulatory (inhibitor) subunit 13B; transformation related protein 53 binding protein 2; tumor protein p53 binding protein, 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:21981); (R-MMU-6804759)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;24129315;26119234;34428180;35822049;36656967;40885482;9630982", "class_list": "", "function": "After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC) cycling and induces p53-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC self-renewal and accumulation of DNA damage in p53 null HSCs., [RefSeq, PubMed]; Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury., [RefSeq, PubMed]; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (By similarity). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0045786 negative regulation of cell cycle;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62415-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PIE5-1", "uniprot_id": [ { "id": "AT1A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PIE5", "type": "external" } ], "mass": 112217.0, "length": 1020, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-2", "gene_name": "Atp1a2", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_848492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848492", "type": "external" } ], "gene_names_uniprotkb": "Atp1a2", "gene_names_refseq": "Atp1a2; Atpa-3; mKIAA0778", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-2; 7.2.2.13; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2", "protein_names_refseq": "Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2 precursor; sodium/potassium-transporting ATPase subunit alpha-2", "tax_id": 10090, "disease": "alternating hemiplegia of childhood (Disease Ontology:DOID:0050635); familial hemiplegic migraine (Disease Ontology:DOID:0060178); developmental and epileptic encephalopathy 98 (Disease Ontology:DOID:0070384); familial hemiplegic migraine 2 (Disease Ontology:DOID:0111182); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); migraine with aura (Disease Ontology:DOID:10024); hypertension (Disease Ontology:DOID:10763); benign neonatal seizures (Disease Ontology:DOID:14264); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:98660); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15564586;21183079;21750661;22645316;29187734;30899004;33300544;34428180;36288343;38015828;39927985;40684658", "class_list": "", "function": "Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (By similarity). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice. Publication Status: Online-Only, [RefSeq, PubMed]; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 12, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q80UZ8", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0008344 adult locomotory behavior;GO:0008542 visual learning;GO:0035094 response to nicotine;GO:0002087 regulation of respiratory gaseous exchange by nervous system process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q6PIE5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3D9-1", "uniprot_id": [ { "id": "ATPD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3D9", "type": "external" } ], "mass": 17600.0, "length": 168, "protein_name": "ATP synthase F(1) complex subunit delta, mitochondrial", "gene_name": "Atp5f1d", "organism": "Mouse", "refseq_name": "ATP synthase F(1) complex subunit delta, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_079589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079589", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1d; Atp5d", "gene_names_refseq": "0610008F14Rik; 1500000I11Rik; Atp5d; Atp5f1d", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase F1 subunit delta; F-ATPase delta subunit", "protein_names_refseq": "ATP synthase F(1) complex subunit delta, mitochondrial isoform 1 precursor; ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase subunit delta, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; F-ATPase delta subunit", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); mitochondrial complex V (ATP synthase) deficiency nuclear type 5 (Disease Ontology:DOID:0070463); Alzheimer's disease (Disease Ontology:DOID:10652); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:66043); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21750661;23576753;23806337;24615392;26740625;29499186;34428180;36288343;36686378;37453647", "class_list": "", "function": "ATP5D Is a Potential Biomarker for Male Fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation., [RefSeq, PubMed]; Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The interaction between Mpl and Atp5d was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0015078 proton transmembrane transporter activity;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane;GO:0005814 centriole;GO:0097228 sperm principal piece", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0009060 aerobic respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D3D9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35143-1", "uniprot_id": [ { "id": "ATIF1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35143", "type": "external" } ], "mass": 12159.0, "length": 106, "protein_name": "ATPase inhibitor, mitochondrial", "gene_name": "Atp5if1", "organism": "Mouse", "refseq_name": "ATPase inhibitor, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031538", "type": "external" } ], "gene_names_uniprotkb": "Atp5if1; Atpif1; Atpi; If1", "gene_names_refseq": "Atp5if1; Atpif1; Atpi; IF(1); If1", "protein_names_uniprotkb": "ATPase inhibitor, mitochondrial; ATP synthase F1 subunit epsilon; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase", "protein_names_refseq": "ATP synthase F1 subunit epsilon; ATPase inhibitor, mitochondrial precursor; ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; inhibitor of F(1)F(o)-ATPase", "tax_id": 10090, "disease": "blindness (Disease Ontology:DOID:1432)", "pathway": " (mmu:11983)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19096392;20538613;21750661;23135403;23806337;38754030;9497501", "class_list": "", "function": "Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (PubMed:23135403)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis., [RefSeq, PubMed]; SIRTUIN 5 ALLEVIATES EXCESSIVE MITOCHONDRIAL FISSION VIA DESUCCINYLATION OF ATPASE INHIBITORY FACTOR 1 IN SEPSIS-INDUCED ACUTE KIDNEY INJURY., [RefSeq, PubMed]; The identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development Erratum:[Nature. 2013 Apr 18;496(7445):386], [RefSeq, PubMed]; The study reveals that IEX-1 targets the mitochondrial F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS production., [RefSeq, PubMed]; This gene encodes a member of the ATPase inhibitor family of proteins. This protein has been shown to negatively regulate the ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene is associated with reduced heme synthesis in differentiating erythroid cells. Misregulation of this gene has been found to lead to increased aerobic glycolysis in mouse cancer cells, while high expression levels of this gene have been correlated with gastric and liver cancer severity in human patients. A pseudogene of this gene has been identified. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D879", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0043532 angiostatin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0032991 protein-containing complex", "go_biological_process": "GO:0002931 response to ischemia;GO:0030218 erythrocyte differentiation;GO:0001937 negative regulation of endothelial cell proliferation;GO:0051882 mitochondrial depolarization;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35143-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56135-1", "uniprot_id": [ { "id": "ATPK_MOUSE", "url": "https://www.uniprot.org/uniprot/P56135", "type": "external" } ], "mass": 10344.0, "length": 88, "protein_name": "ATP synthase F(0) complex subunit f, mitochondrial", "gene_name": "Atp5mf", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit f, mitochondrial", "refseq_ac": [ { "id": "NP_065607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065607", "type": "external" } ], "gene_names_uniprotkb": "Atp5mf; Atp5j2", "gene_names_refseq": "1110019H14Rik; Atp5j2; Atp5mf", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase membrane subunit f", "protein_names_refseq": "ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase subunit f, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f; hypothetical protein, clone:2-31", "tax_id": 10090, "disease": "", "pathway": " (mmu:57423); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10679242;21750661;22645316;23576753;31219806;33300544;34428180;36288343;37453647", "class_list": "", "function": "Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THX9;Q9JMF4", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031965 nuclear membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0006754 ATP biosynthetic process;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P56135-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88848-1", "uniprot_id": [ { "id": "ARL6_MOUSE", "url": "https://www.uniprot.org/uniprot/O88848", "type": "external" } ], "mass": 20959.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 6", "gene_name": "Arl6", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001334173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334173", "type": "external" } ], "gene_names_uniprotkb": "Arl6; Bbs3", "gene_names_refseq": "1110018H24Rik; 2210411E14Rik; Arl6; BBS3", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6", "protein_names_refseq": "ADP-ribosylation factor-like protein 6 isoform 2; ADP-ribosylation factor-like protein 6; ADP-ribosylation-like 6; ADP-ribosylation-like factor homolog ARL6", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 1 (Disease Ontology:DOID:0110123); Bardet-Biedl syndrome 3 (Disease Ontology:DOID:0110125); retinitis pigmentosa 55 (Disease Ontology:DOID:0110370); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:56297); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10508919;16172987;20333246;21750661;24939912;37507081", "class_list": "", "function": "ARL6 was expressed in the neural plate and probably in the somites, [RefSeq, PubMed]; Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity). Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (PubMed:24939912). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (By similarity). Isoform 2 may be required for proper retinal function and organization (PubMed:20333246)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY77", "ec_number_list": [], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005543 phospholipid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0007265 Ras protein signal transduction;GO:0007420 brain development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88848-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50429-1", "uniprot_id": [ { "id": "ARSB_MOUSE", "url": "https://www.uniprot.org/uniprot/P50429", "type": "external" } ], "mass": 59647.0, "length": 534, "protein_name": "Arylsulfatase B", "gene_name": "Arsb", "organism": "Mouse", "refseq_name": "arylsulfatase B precursor", "refseq_ac": [ { "id": "NP_033842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033842", "type": "external" } ], "gene_names_uniprotkb": "Arsb; As1-s; As1", "gene_names_refseq": "1110007C02Rik; Arsb; As-1r; As-1s; As-1t; As-1; As1-r; As1-s; As1-t; As1; Asr-1; Ast-1", "protein_names_uniprotkb": "Arylsulfatase B; 3.1.6.12; ASB; G4S; N-acetylgalactosamine-4-sulfatase", "protein_names_refseq": "ASB; G4S; N-acetylgalactosamine-4-sulfatase; arylsulfatase B complex; arylsulfatase B precursor; arylsulfatase B regulation; arylsulfatase B structural; arylsulfatase B temporal regulation", "tax_id": 10090, "disease": "mucopolysaccharidosis VI (Disease Ontology:DOID:12800)", "pathway": " (mmu:11881); (R-MMU-1663150); (R-MMU-2024101); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1572648;16174644;19536613;21750661;26740625;30899004;37507081;40885482;8710849", "class_list": "glycogene", "function": "Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q32KJ1;Q3TYV7;Q3U4Q6;Q8C404", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0043890 N-acetylgalactosamine-6-sulfatase activity;GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0003943 N-acetylgalactosamine-4-sulfatase activity;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0005764 lysosome", "go_biological_process": "GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007584 response to nutrient;GO:0010976 positive regulation of neuron projection development;GO:0006914 autophagy;GO:0009268 response to pH", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P50429-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64364-1", "uniprot_id": [ { "id": "ARF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64364", "type": "external" } ], "mass": 19238.0, "length": 169, "protein_name": "Tumor suppressor ARF", "gene_name": "Cdkn2a", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase inhibitor 2A isoform p19ARF", "refseq_ac": [ { "id": "NP_034007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034007", "type": "external" } ], "gene_names_uniprotkb": "Cdkn2a; P16ink4a", "gene_names_refseq": "ARF-INK4a; Arf; Cdkn2a; INK4a-ARF; Ink4a/Arf; MTS1; Pctr1; p16(INK4a); p16INK4a; p16; p19; p19ARF", "protein_names_uniprotkb": "Tumor suppressor ARF; ARF; Alternative reading frame; Cyclin-dependent kinase inhibitor 2A; p19ARF", "protein_names_refseq": "CDK4I; alternative reading frame; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A isoform p19ARF; cyclin-dependent kinase inhibitor protein; mitochondrial smARF; p16-INK4a; p16-INK4", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma and neural system tumor syndrome (Disease Ontology:DOID:0111511); dysplastic nevus syndrome (Disease Ontology:DOID:10041); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); leukemia (Disease Ontology:DOID:1240); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); neurilemmoma (Disease Ontology:DOID:3192); rhabdomyosarcoma (Disease Ontology:DOID:3247); germinoma (Disease Ontology:DOID:3304); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); sarcomatoid mesothelioma (Disease Ontology:DOID:4488); pancreatic carcinoma (Disease Ontology:DOID:4905); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); uterine carcinosarcoma (Disease Ontology:DOID:6171); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); neuroblastoma (Disease Ontology:DOID:769); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12578)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10097151;10359817;10753221;10898794;11327858;12154087;15105443;15361884;15567177;15601844;15672607;16713577;17110379;17486078;17546045;17936562;20513429;22645316;28528544;7651726;8521522;9012842;9021155;9178896;9393858;9482902;9529248;9667743", "class_list": "", "function": "Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein., [UniProtKB]; Capable of inducing cell cycle arrest in G1 and G2 phases (PubMed:8521522, PubMed:9393858). Acts as a tumor suppressor (PubMed:15601844, PubMed:17936562, PubMed:8521522, PubMed:9393858). Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus (PubMed:10359817, PubMed:9529248). This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis (PubMed:10359817). Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes (PubMed:15361884). Binds to BCL6 and down-regulates BCL6-induced transcriptional repression (PubMed:15567177). Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression (By similarity). Binds to TOP1/TOPOI and stimulates its activity (By similarity). This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation (By similarity). Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing (By similarity). Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (PubMed:20513429). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarity). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1 (By similarity). Binds to HUWE1 and represses its ubiquitin ligase activity (By similarity). May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; May be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 45, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4U255;Q9QXC7;Q9R051", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051059 NF-kappaB binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035985 senescence-associated heterochromatin focus;GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0001953 negative regulation of cell-matrix adhesion;GO:0007265 Ras protein signal transduction;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q64364-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQH0-1", "uniprot_id": [ { "id": "ATX2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQH0", "type": "external" } ], "mass": 110649.0, "length": 1049, "protein_name": "Ataxin-2-like protein", "gene_name": "Atxn2l", "organism": "Mouse", "refseq_name": "ataxin-2-like protein isoform 1", "refseq_ac": [ { "id": "NP_898841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898841", "type": "external" } ], "gene_names_uniprotkb": "Atxn2l; A2lp", "gene_names_refseq": "A2D; A2LG; A2RP; A2lp; Atxn2l; Atxnl2", "protein_names_uniprotkb": "Ataxin-2-like protein", "protein_names_refseq": "ataxin 2 related protein; ataxin-2-like protein isoform 1; ataxin-2-like protein", "tax_id": 10090, "disease": "spinocerebellar ataxia 2 (Disease Ontology:DOID:0050955); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:233871)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17242355;17322884;19131326;19144319;21183079;21750661;22517741;22645316;22826440;23806337;24788674;25153642;28135057;28528544;31219806;32211685;32698485;32782141;32848054;34428180;34678516;35822049;36852467;39927985;40021952;40885482;40997131", "class_list": "", "function": "Involved in the regulation of stress granule and P-body formation., [UniProtKB, UniProtKB]; Mid-Gestation lethality of Atxn2l-Ablated Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Specific expression and alternative splicing of mouse genes during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q80XN9;Q8K059", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0016607 nuclear speck;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q7TQH0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHS6-1", "uniprot_id": [ { "id": "ARMX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHS6", "type": "external" } ], "mass": 42620.0, "length": 379, "protein_name": "Armadillo repeat-containing X-linked protein 3", "gene_name": "Armcx3", "organism": "Mouse", "refseq_name": "armadillo repeat-containing X-linked protein 3", "refseq_ac": [ { "id": "NP_082146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082146", "type": "external" } ], "gene_names_uniprotkb": "Armcx3; Alex3", "gene_names_refseq": "1200004E24Rik; ALEX3; Armcx3", "protein_names_uniprotkb": "Armadillo repeat-containing X-linked protein 3", "protein_names_refseq": "armadillo repeat-containing X-linked protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71703); (R-MMU-9013404)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19304657;21183079;22569362;23844091;31599954;34428180;35705702;38320000", "class_list": "", "function": "A mammalian-specific Alex3/Galphaq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival., [RefSeq, PubMed]; Regulates mitochondrial aggregation and transport in axons in living neurons (PubMed:22569362, PubMed:23844091). May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2 (PubMed:22569362). Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1 (PubMed:23844091). Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters (PubMed:19304657)., [UniProtKB, PubMed, PubMed, PubMed]; Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3, [RefSeq, PubMed]; The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AKS4;Q91VP8;Q9DC32", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008104 intracellular protein localization;GO:0007005 mitochondrion organization;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BHS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW86-1", "uniprot_id": [ { "id": "ARG33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW86", "type": "external" } ], "mass": 94758.0, "length": 850, "protein_name": "Rho guanine nucleotide exchange factor 33", "gene_name": "Arhgef33", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 33", "refseq_ac": [ { "id": "NP_001138924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138924", "type": "external" } ], "gene_names_uniprotkb": "Arhgef33; Gm941", "gene_names_refseq": "Arhgef33; Gm941", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 33", "protein_names_refseq": "DH and coiled-coil domain-containing protein ENSP00000381780 homolog; Rho guanine nucleotide exchange factor (GEF) 33; rho guanine nucleotide exchange factor 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:381112); (R-MMU-193648); (R-MMU-416482)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BW86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXL7-1", "uniprot_id": [ { "id": "ARFRP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXL7", "type": "external" } ], "mass": 22659.0, "length": 201, "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "Arfrp1", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-related protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001159463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159463", "type": "external" } ], "gene_names_uniprotkb": "Arfrp1", "gene_names_refseq": "1500006I01Rik; Arfrp1", "protein_names_uniprotkb": "ADP-ribosylation factor-related protein 1; ARF-related protein 1", "protein_names_refseq": "ADP-ribosylation factor related protein 1; ADP-ribosylation factor-related protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76688); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11839814;17127620;18662990;18666447;21750661;22505585;22927645;23033902;24186947;33359402", "class_list": "", "function": "ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin., [RefSeq, PubMed]; ARFRP1 and the Golgi apparatus play an important role in lipoprotein maturation in the liver., [RefSeq, PubMed]; Data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 secretion and GLUT2 sorting and is thereby essential for normal growth and glycogen storage, [RefSeq, PubMed]; The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic beta-cells., [RefSeq, PubMed]; The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium., [RefSeq, PubMed]; The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]; This study provides the first detailed analysis of the regional distribution of ARFRP1 in the mouse brain and a quantitative view of its changes following sleep deprivation., [RefSeq, PubMed]; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0007369 gastrulation;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BXL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YI1-1", "uniprot_id": [ { "id": "ATG13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YI1", "type": "external" } ], "mass": 56441.0, "length": 516, "protein_name": "Autophagy-related protein 13", "gene_name": "Atg13", "organism": "Mouse", "refseq_name": "autophagy-related protein 13 isoform 7", "refseq_ac": [ { "id": "NP_663503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663503", "type": "external" } ], "gene_names_uniprotkb": "Atg13; D2Ertd391e; Kiaa0652", "gene_names_refseq": "1110053A20Rik; Atg13; D2Ertd391e; Harbi1", "protein_names_uniprotkb": "Autophagy-related protein 13", "protein_names_refseq": "ATG13 autophagy related 13 homolog; autophagy-related protein 13 isoform 7; autophagy-related protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:51897); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19211835;19258318;35957534", "class_list": "", "function": "Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation., [UniProtKB, PubMed]; Beclin1- and Atg13-dependent autophagy activation and morroniside have synergistic effect on osteoblastogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AH18;Q80TU9", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0019901 protein kinase binding;GO:0019887 protein kinase regulator activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010508 positive regulation of autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91YI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YY4-1", "uniprot_id": [ { "id": "ATPF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YY4", "type": "external" } ], "mass": 33289.0, "length": 289, "protein_name": "ATP synthase mitochondrial F1 complex assembly factor 2", "gene_name": "Atpaf2", "organism": "Mouse", "refseq_name": "ATP synthase mitochondrial F1 complex assembly factor 2 isoform 1", "refseq_ac": [ { "id": "NP_663402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663402", "type": "external" } ], "gene_names_uniprotkb": "Atpaf2", "gene_names_refseq": "ATP12p; ATP12; Atpaf2", "protein_names_uniprotkb": "ATP synthase mitochondrial F1 complex assembly factor 2", "protein_names_refseq": "ATP synthase mitochondrial F1 complex assembly factor 2 isoform 1", "tax_id": 10090, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 1 (Disease Ontology:DOID:0050768)", "pathway": " (mmu:246782)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23806337;33639177;34375736", "class_list": "", "function": "Conserved role of ATP synthase in mammalian cilia., [RefSeq, PubMed]; Plays a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP08", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0043461 proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J83-1", "uniprot_id": [ { "id": "ATG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J83", "type": "external" } ], "mass": 32402.0, "length": 275, "protein_name": "Autophagy protein 5", "gene_name": "Atg5", "organism": "Mouse", "refseq_name": "autophagy protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001300942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300942", "type": "external" } ], "gene_names_uniprotkb": "Atg5; Apg5l", "gene_names_refseq": "2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l; Atg5; Paddy", "protein_names_uniprotkb": "Autophagy protein 5; APG5-like", "protein_names_refseq": "autophagy protein 5 isoform 2; autophagy protein 5", "tax_id": 10090, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 25 (Disease Ontology:DOID:0080259); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); ischemia (Disease Ontology:DOID:326)", "pathway": " (mmu:11793); (R-MMU-1632852); (R-MMU-5205685); (R-MMU-8934903)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "11266458;12482611;12665549;12890687;17190837;17709747;17912025;18188005;18768753;19417210;19844159;20171125;22082872;24089205;24089209;28231469;38227290", "class_list": "", "function": "(Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection., [UniProtKB, PubMed]; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (PubMed:38227290)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity)., [UniProtKB, UniProtKB]; The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019776 Atg8-family ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1904973 positive regulation of viral translation;GO:0061684 chaperone-mediated autophagy;GO:0002718 regulation of cytokine production involved in immune response;GO:0000045 autophagosome assembly;GO:0039689 negative stranded viral RNA replication", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99J83-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX83-1", "uniprot_id": [ { "id": "ARMX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX83", "type": "external" } ], "mass": 50643.0, "length": 456, "protein_name": "Armadillo repeat-containing X-linked protein 1", "gene_name": "Armcx1", "organism": "Mouse", "refseq_name": "armadillo repeat-containing X-linked protein 1", "refseq_ac": [ { "id": "NP_001159849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159849", "type": "external" } ], "gene_names_uniprotkb": "Armcx1", "gene_names_refseq": "3010033I09Rik; ALEX1; Armcx1", "protein_names_uniprotkb": "Armadillo repeat-containing X-linked protein 1", "protein_names_refseq": "armadillo repeat-containing X-linked protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78248)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "22569362;25428506;28009275;30779550;31219806;37187340;37454781;38492796", "class_list": "", "function": "Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport Pathway Involving Miro1 After Traumatic Brain Injury., [RefSeq, PubMed]; Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death., [RefSeq, PubMed]; Armcx1 is upregulated after axotomy in a model with robust regeneration. Armcx1 overexpression enhances mitochondrial transport in adult retinal ganglion cells. Armcx1 also promotes both neuronal survival and axon regeneration after injury, and these effects depend on its mitochondrial localization. Erratum:[Neuron. 2017 May 3;94(3):689. doi: 10.1016/j.neuron.2017.04.028. PMID: 28472662], [RefSeq, PubMed]; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with Miro1., [UniProtKB, PubMed]; Roles of syntaphilin and armadillo repeat-containing X-linked protein 1 in brain injury after experimental intracerebral hemorrhage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0061484 hematopoietic stem cell homeostasis;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CX83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0L7-1", "uniprot_id": [ { "id": "ARM10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0L7", "type": "external" } ], "mass": 33311.0, "length": 306, "protein_name": "Armadillo repeat-containing protein 10", "gene_name": "Armc10", "organism": "Mouse", "refseq_name": "armadillo repeat-containing protein 10 isoform 1", "refseq_ac": [ { "id": "NP_080310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080310", "type": "external" } ], "gene_names_uniprotkb": "Armc10", "gene_names_refseq": "2810037C14Rik; Armc10; Svh", "protein_names_uniprotkb": "Armadillo repeat-containing protein 10", "protein_names_refseq": "armadillo repeat-containing protein 10 isoform 1; armadillo repeat-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:67211)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15345747;19144319;21183079;21750661;34203471;34428180;37556559", "class_list": "", "function": "May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZY2;Q9CUN3;Q9CZ87", "ec_number_list": [], "go_molecular_function": "GO:0002039 p53 binding;GO:0050692 DNA binding domain binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0040010 positive regulation of growth rate;GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D0L7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70191-1", "uniprot_id": [ { "id": "ATF5_MOUSE", "url": "https://www.uniprot.org/uniprot/O70191", "type": "external" } ], "mass": 30331.0, "length": 283, "protein_name": "Cyclic AMP-dependent transcription factor ATF-5", "gene_name": "Atf5", "organism": "Mouse", "refseq_name": "cyclic AMP-dependent transcription factor ATF-5", "refseq_ac": [ { "id": "NP_109618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109618", "type": "external" } ], "gene_names_uniprotkb": "Atf5; Atfx; Nap1", "gene_names_refseq": "AFTA; Atf5; Atf7; Atfx; ODA-10", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-5; Activating transcription factor 5-alpha/beta; BZIP protein ATF7; NAP1; NRIF3-associated protein; Transcription factor ATFx; Transcription factor-like protein ODA-10; cAMP-dependent transcription factor ATF-5", "protein_names_refseq": "BZIP protein ATF7; NAP1; NRIF3-associated protein; activating transcription factor 5-alpha/beta; activating transcription factor 7; activating transcription factor X; cAMP-dependent transcription factor ATF-5; cyclic AMP-dependent transcription factor ATF-5; transcription factor ATFx; transcription factor-like protein ODA-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:107503)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11278933;11986327;12130540;12213205;1371974;21750661;21768648;22095825;23090999;24216764;35820727", "class_list": "", "function": "Inhibition of apoptosis by ATFx, [RefSeq, PubMed]; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate. Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (PubMed:22095825). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (PubMed:23090999). May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (By similarity). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity) (PubMed:12130540). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation. Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58E51;Q99NH6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0031072 heat shock protein binding;GO:0019900 kinase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70191-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03265-1", "uniprot_id": [ { "id": "ATPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03265", "type": "external" } ], "mass": 59753.0, "length": 553, "protein_name": "ATP synthase F(1) complex subunit alpha, mitochondrial", "gene_name": "Atp5f1a", "organism": "Mouse", "refseq_name": "ATP synthase F(1) complex subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031531", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1a; Atp5a1", "gene_names_refseq": "Atp5a1; Atp5f1a; Atpm; D18Ertd206e; Mom2", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase F1 subunit alpha", "protein_names_refseq": "ATP synthase F(1) complex subunit alpha, mitochondrial precursor; ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1; modifier of Min 2", "tax_id": 10090, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 4A (Disease Ontology:DOID:0070461); mitochondrial complex V (ATP synthase) deficiency nuclear type 4B (Disease Ontology:DOID:0070462); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); combined oxidative phosphorylation deficiency 22 (Disease Ontology:DOID:0111498); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pulmonary hypertension (Disease Ontology:DOID:6432); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:11946); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 32, "publication_id_list": "15648052;17438143;19941651;21183079;21750661;22645316;23386199;23576753;23806337;24129315;25428506;25605945;26358770;26495903;30084848;31219806;31599954;33300544;33725478;34428180;35820727;35984892;36064721;36210013;36288343;37453647;37507081;39627609;3980088;39927985;40684658;7916601", "class_list": "", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB]; Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFN0;Q3THN8;Q3TPR0;Q3TPV3;Q3TZU3;Q3UIR7;Q543Y6", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043531 ADP binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0045471 response to ethanol;GO:0006754 ATP biosynthetic process;GO:0001937 negative regulation of endothelial cell proliferation;GO:0071549 cellular response to dexamethasone stimulus", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q03265-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4T0-1", "uniprot_id": [ { "id": "ATG2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P4T0", "type": "external" } ], "mass": 210939.0, "length": 1914, "protein_name": "Autophagy-related protein 2 homolog A", "gene_name": "Atg2a", "organism": "Mouse", "refseq_name": "autophagy-related protein 2 homolog A isoform 2", "refseq_ac": [ { "id": "NP_919329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919329", "type": "external" } ], "gene_names_uniprotkb": "Atg2a; Kiaa0404", "gene_names_refseq": "1810013C15Rik; A830054M12; Atg2a; mKIAA0404", "protein_names_uniprotkb": "Autophagy-related protein 2 homolog A", "protein_names_refseq": "ATG2 autophagy related 2 homolog A; autophagy-related protein 2 homolog A isoform 2; autophagy-related protein 2 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:329015)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21183079;21698225;21750661;25428506;31219806;34428180;35820727;36210013", "class_list": "", "function": "(Microbial infection) Mediates the intracellular lifestyle of Cryptococcus neoformans by supporting infection., [UniProtKB, PubMed]; Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9I1;Q6PHN0;Q6ZQC4;Q8R213", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0010508 positive regulation of autophagy;GO:0000422 autophagy of mitochondrion;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P4T0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70305-1", "uniprot_id": [ { "id": "ATX2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70305", "type": "external" } ], "mass": 136485.0, "length": 1285, "protein_name": "Ataxin-2", "gene_name": "Atxn2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atxn2; Atx2; Sca2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ataxin-2; Spinocerebellar ataxia type 2 protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "spinocerebellar ataxia 2 (Disease Ontology:DOID:0050955); late onset Parkinson's disease (Disease Ontology:DOID:0060892); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:20239)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18602463;21183079;21750661;22517741;22645316;24129315;27669760;28528544;30084848;31219806;32782141;32848054;34203471;34428180;34678516;34887587;35820727;35822049;36288343;36852467;40021952;40885482;8896555;9668173", "class_list": "", "function": "Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "P97421", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005154 epidermal growth factor receptor binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0050905 neuromuscular process;GO:0048812 neuron projection morphogenesis;GO:0040015 negative regulation of multicellular organism growth;GO:0002091 negative regulation of receptor internalization;GO:0021702 cerebellar Purkinje cell differentiation", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "O70305-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QY64-1", "uniprot_id": [ { "id": "ATAD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4QY64", "type": "external" } ], "mass": 203909.0, "length": 1826, "protein_name": "ATPase family AAA domain-containing protein 5", "gene_name": "Atad5", "organism": "Mouse", "refseq_name": "ATPase family AAA domain-containing protein 5", "refseq_ac": [ { "id": "NP_001025027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025027", "type": "external" } ], "gene_names_uniprotkb": "Atad5; Frag1", "gene_names_refseq": "Atad5; C130052G03Rik; FRAG1; Gm17", "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 5; Chromosome fragility-associated gene 1 protein", "protein_names_refseq": "ATPase family AAA domain-containing protein 5; chromosome fragility associated gene 1; chromosome fragility-associated gene 1 protein", "tax_id": 10090, "disease": "neurilemmoma (Disease Ontology:DOID:3192)", "pathway": " (mmu:237877)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15983387;21183079;21750661;21901109;25404367;25428506;25795125;30059200;30084848;31219806;34428180;35820727", "class_list": "", "function": "Atad5+/m cells accumulate in the S phase, have decreased proliferation, and have reduced double-strand breaks, class switch recombination, and translocations, [RefSeq, PubMed]; Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review] Review article, [RefSeq, PubMed]; Has an important role in DNA replication and in maintaining genome integrity during replication stress. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway. As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle. This seems to be dependent on its ATPase activity. Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner. Ultimately this enables replication fork regression, breakage, and eventual fork restart. Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks. Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (By similarity)., [UniProtKB, PubMed, UniProtKB]; Loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMG5;Q3UW85;Q3V306;Q3V3T9;Q5SSK4;Q8BUH4;Q8CGG7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0061860 DNA clamp unloader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031391 Elg1 RFC-like complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006974 DNA damage response;GO:0030890 positive regulation of B cell proliferation;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q4QY64-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XK6-2", "uniprot_id": [ { "id": "ATG2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XK6", "type": "external" } ], "mass": 231399.0, "length": 2075, "protein_name": "Autophagy-related protein 2 homolog B", "gene_name": "Atg2b", "organism": "Mouse", "refseq_name": "autophagy-related protein 2 homolog B isoform 1", "refseq_ac": [ { "id": "NP_083930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083930", "type": "external" } ], "gene_names_uniprotkb": "Atg2b", "gene_names_refseq": "2410024A21Rik; Atg2b; C030004M05Rik; C630028L02Rik; mKIAA4067", "protein_names_uniprotkb": "Autophagy-related protein 2 homolog B", "protein_names_refseq": "ATG2 autophagy related 2 homolog B; autophagy-related protein 2 homolog B isoform 1; autophagy-related protein 2 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:76559)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21183079;25428506;30084848;30779550;31219806;34428180;35820727;37828378", "class_list": "", "function": "Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0PJL7;Q8BIQ4;Q8BIV0;Q8R1H5;Q9CWK6", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0000422 autophagy of mitochondrion;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy;GO:0061723 glycophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80XK6-2", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YI4-1", "uniprot_id": [ { "id": "ARRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YI4", "type": "external" } ], "mass": 46314.0, "length": 410, "protein_name": "Beta-arrestin-2", "gene_name": "Arrb2", "organism": "Mouse", "refseq_name": "beta-arrestin-2 isoform a", "refseq_ac": [ { "id": "NP_001258287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258287", "type": "external" } ], "gene_names_uniprotkb": "Arrb2", "gene_names_refseq": "Arr3; Arrb2", "protein_names_uniprotkb": "Beta-arrestin-2; Arrestin beta-2", "protein_names_refseq": "arrestin 3; beta arr2; beta-arrestin-2 isoform a; beta-arrestin-2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); sensorineural hearing loss (Disease Ontology:DOID:10003); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); drug psychosis (Disease Ontology:DOID:1742); opiate dependence (Disease Ontology:DOID:2559); glioblastoma (Disease Ontology:DOID:3068); brain infarction (Disease Ontology:DOID:3454); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:216869); (R-MMU-418555); (R-MMU-456926); (R-MMU-5099900); (R-MMU-5635838); (R-MMU-5674135); (R-MMU-5689880); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9839389)", "pathway_count": 10, "publication_count": 20, "publication_id_list": "11588219;12167659;12944399;16051150;17540773;18034455;18194271;18250455;18337459;18497258;18604210;19122674;21750661;25147978;25428506;26873857;30084848;30779550;34428180;38883814", "class_list": "", "function": "Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:38883814). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation (PubMed:38883814). The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as a signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in IL8-mediated granule release in neutrophils (By similarity). Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in both localization to primary cilium and endocytosis of smoothened (SMO) in a GRK2-dependent process (PubMed:18497258). Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCM2;Q5F2D8;Q5F2E0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0001934 positive regulation of protein phosphorylation;GO:0006897 endocytosis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q91YI4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W92-1", "uniprot_id": [ { "id": "BORG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W92", "type": "external" } ], "mass": 43096.0, "length": 409, "protein_name": "Cdc42 effector protein 1", "gene_name": "Cdc42ep1", "organism": "Mouse", "refseq_name": "cdc42 effector protein 1", "refseq_ac": [ { "id": "NP_081495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081495", "type": "external" } ], "gene_names_uniprotkb": "Cdc42ep1; Borg5; Cep1", "gene_names_refseq": "1810058K22Rik; Borg5; CEP1; Cdc42ep1; MSE55", "protein_names_uniprotkb": "Cdc42 effector protein 1; Binder of Rho GTPases 5", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 1; binder of Rho GTPase 5; binder of Rho GTPases 5; cdc42 effector protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:104445); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15345747;20506138;21183079;21750661;24129315;24451259;25428506;34428180", "class_list": "", "function": "Borg5 is required for angiogenesis by regulating persistent directional migration of the cardiac microvascular endothelial cells., [RefSeq, PubMed]; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity)., [UniProtKB]; Report that differentiation of embryonic stem cells toward trophectoderm is accompanied by enhanced actin protrusion and cell motility that require upregulation of Borg5., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8M1", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0012505 endomembrane system", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91W92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAJ1-1", "uniprot_id": [ { "id": "BCR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAJ1", "type": "external" } ], "mass": 143072.0, "length": 1270, "protein_name": "Breakpoint cluster region protein", "gene_name": "Bcr", "organism": "Mouse", "refseq_name": "breakpoint cluster region protein", "refseq_ac": [ { "id": "NP_001074881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074881", "type": "external" } ], "gene_names_uniprotkb": "Bcr; Kiaa3017", "gene_names_refseq": "5133400C09Rik; Bcr; mKIAA3017", "protein_names_uniprotkb": "Breakpoint cluster region protein; 2.7.11.1", "protein_names_refseq": "breakpoint cluster region homolog; breakpoint cluster region protein", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:110279); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 8, "publication_count": 23, "publication_id_list": "10.3389/fragi.2021.757801;16452087;17000758;17116687;17242355;17947660;20962234;21183079;21750661;22517741;2263470;24129315;25331951;32276588;32782141;33300544;34190380;34428180;34941574;35820727;35822049;36852467;40885482", "class_list": "", "function": "CRISPR/CAS9-mediated knockout of Abi1 inhibits p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways. Publication Status: Online-Only, [RefSeq, PubMed]; DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3. Publication Status: Online-Only, [RefSeq, PubMed]; Loss function of Bcr mutation causes gastrointestinal dysmotility and brain developmental defects., [RefSeq, PubMed]; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PZL3;Q61339;Q6ZPE5;Q99LW5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": 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"2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:1905522 negative regulation of macrophage migration;GO:0032496 response to lipopolysaccharide;GO:0042472 inner ear morphogenesis;GO:0043312 neutrophil degranulation;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q6PAJ1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24270-1", "uniprot_id": [ { "id": "CATA_MOUSE", "url": "https://www.uniprot.org/uniprot/P24270", "type": "external" } ], "mass": 59795.0, "length": 527, "protein_name": "Catalase", "gene_name": "Cat", "organism": "Mouse", "refseq_name": "catalase", "refseq_ac": [ { "id": "NP_033934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033934", "type": "external" } ], "gene_names_uniprotkb": "Cat; Cas-1; Cas1", "gene_names_refseq": "2210418N07; Cas-1; Cas1; Cat; Cs-1", "protein_names_uniprotkb": "Catalase; 1.11.1.6", "protein_names_refseq": "catalase 1; catalase", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); chronic venous insufficiency (Disease Ontology:DOID:0050853); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); Graves ophthalmopathy (Disease Ontology:DOID:0081120); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); retinitis pigmentosa (Disease Ontology:DOID:10584); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); optic neuritis (Disease Ontology:DOID:1210); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Behcet's disease (Disease Ontology:DOID:13241); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); acatalasia (Disease Ontology:DOID:2582); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast adenocarcinoma (Disease Ontology:DOID:3458); toxic encephalopathy (Disease Ontology:DOID:3602); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ureteral obstruction (Disease Ontology:DOID:5199); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congestive heart failure (Disease Ontology:DOID:6000); fibromyalgia (Disease Ontology:DOID:631); acne (Disease Ontology:DOID:6543); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); scabies (Disease Ontology:DOID:8295); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); seborrheic dermatitis (Disease Ontology:DOID:8741); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); phenylketonuria (Disease Ontology:DOID:9281); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); stomatitis (Disease Ontology:DOID:9637); senile cataract (Disease Ontology:DOID:9669); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (mmu:12359); (R-MMU-3299685); (R-MMU-6798695); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "17208939;17242355;21183079;21750661;2268310;22872234;23576753;23806337;2395665;25605945;26495903;26740625;28135057;28528544;2868912;30779550;31219806;31361958;34428180;36210013;36288343;3654595;37453647;37507081;37597421;38594299;38844154;8088826", "class_list": "", "function": "Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells., [UniProtKB, UniProtKB]; DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy., [RefSeq, PubMed]; Mitochondria-targeted catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Calpha axis., [RefSeq, PubMed]; Mitochondrial targeted catalase improves muscle strength following arteriovenous fistula creation in mice with chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, 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"2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0006979 response to oxidative stress;GO:0008203 cholesterol metabolic process;GO:0010288 response to lead ion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P24270-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61686-1", "uniprot_id": [ { "id": "CBX5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61686", "type": "external" } ], "mass": 22186.0, "length": 191, "protein_name": "Chromobox protein homolog 5", "gene_name": "Cbx5", "organism": "Mouse", "refseq_name": "chromobox protein homolog 5", "refseq_ac": [ { "id": "NP_001070257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070257", "type": "external" } ], "gene_names_uniprotkb": "Cbx5; Hp1a", "gene_names_refseq": "2610029O15Rik; Cbx5; HP1; Hp1alpha; Hp1a", "protein_names_uniprotkb": "Chromobox protein homolog 5; HP1 alpha; Heterochromatin protein 1 homolog alpha", "protein_names_refseq": "HP1 alpha; chromobox homolog 5; chromobox protein homolog 5; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; mHP1(alpha)", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:12419); (R-MMU-983231)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10562550;11107181;15145825;16452087;19144319;21183079;21750661;22645316;24584199;28135057;28250819;8978696", "class_list": "", "function": "Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1. Required for the formation of the inner centromere., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CS35;Q9CXD1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0017053 transcription repressor complex;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0030261 chromosome condensation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61686-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D920-1", "uniprot_id": [ { "id": "BORC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D920", "type": "external" } ], "mass": 22120.0, "length": 195, "protein_name": "BLOC-1-related complex subunit 5", "gene_name": "Borcs5", "organism": "Mouse", "refseq_name": "BLOC-1-related complex subunit 5 isoform 1", "refseq_ac": [ { "id": "NP_001163950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163950", "type": "external" } ], "gene_names_uniprotkb": "Borcs5; Loh12cr1", "gene_names_refseq": "5830457J20Rik; Borcs5; Loh12cr1", "protein_names_uniprotkb": "BLOC-1-related complex subunit 5", "protein_names_refseq": "BLOC-1-related complex subunit 5 isoform 1; loss of heterozygosity 12 chromosomal region 1 protein homolog; loss of heterozygosity, 12, chromosomal region 1 homolog", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:67774)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJB0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0005764 lysosome;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0007005 mitochondrion organization;GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D920-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04919-1", "uniprot_id": [ { "id": "B3AT_MOUSE", "url": "https://www.uniprot.org/uniprot/P04919", "type": "external" } ], "mass": 103136.0, "length": 929, "protein_name": "Band 3 anion transport protein", "gene_name": "Slc4a1", "organism": "Mouse", "refseq_name": "band 3 anion transport protein", "refseq_ac": [ { "id": "NP_035533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035533", "type": "external" } ], "gene_names_uniprotkb": "Slc4a1; Ae1", "gene_names_refseq": "Ae1; CD233; Empb3; Slc4a1; l11Jus51", "protein_names_uniprotkb": "Band 3 anion transport protein; AE 1; Anion exchange protein 1; Anion exchanger 1; MEB3; Solute carrier family 4 member 1", "protein_names_refseq": "AE 1; MEB3; anion exchange protein 1; anion exchanger 1; band 3 anion transport protein; erythrocyte membrane protein band 3; solute carrier family 4 member 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic acidosis (Disease Ontology:DOID:0050758); hereditary spherocytosis type 4 (Disease Ontology:DOID:0110919); iron deficiency anemia (Disease Ontology:DOID:11758); malaria (Disease Ontology:DOID:12365); hereditary spherocytosis (Disease Ontology:DOID:12971); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); hereditary elliptocytosis (Disease Ontology:DOID:2373); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); congenital hemolytic anemia (Disease Ontology:DOID:589)", "pathway": " (mmu:20533); (R-MMU-1237044); (R-MMU-1247673); (R-MMU-425381)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10233746;11908947;16452087;17242355;17785581;21183079;2410791;25428506;26495903;2713407;27802388;28455817;28935714;3015590;3036795;31219806;33725478;34428180;35533989;3840489;38669699;9490702", "class_list": "", "function": "Extracellular vesicle-derived miR-1249-5p regulates influenza A virus-induced acute lung injury in RAW246.7 cells through targeting SLC4A1., [RefSeq, PubMed]; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine., [UniProtKB, UniProtKB]; Unraveling the molecular landscape of kAE1: a narrative review. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0030492 hemoglobin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0014704 intercalated disc", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0055085 transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P04919-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60739-1", "uniprot_id": [ { "id": "BAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60739", "type": "external" } ], "mass": 39740.0, "length": 355, "protein_name": "BAG family molecular chaperone regulator 1", "gene_name": "Bag1", "organism": "Mouse", "refseq_name": "BAG family molecular chaperone regulator 1 isoform 1S", "refseq_ac": [ { "id": "NP_001165210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165210", "type": "external" } ], "gene_names_uniprotkb": "Bag1", "gene_names_refseq": "BAG-1; Bag1; Rap46", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1", "protein_names_refseq": "BAG family molecular chaperone regulator 1 isoform 1S; BAG family molecular chaperone regulator 1; Bcl-2-binding protein; bcl-2-associated athanogene 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); lesion of sciatic nerve (Disease Ontology:DOID:12528); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); cervix carcinoma (Disease Ontology:DOID:2893)", "pathway": " (mmu:12017); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11257006;21750661;38763404;7834747;9396724;9679980;9873016", "class_list": "", "function": "Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons., [RefSeq, PubMed]; Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion., [RefSeq, PubMed]; Co-chaperone for HSP70 and HSC70 chaperone proteins (PubMed:9873016). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity). Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury., [UniProtKB, UniProtKB]; The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon., [RefSeq, PubMed]; The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q561N1;Q6IS45;Q9D7K6", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0051219 phosphoprotein binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001933 negative regulation of protein phosphorylation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60739-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWP8-1", "uniprot_id": [ { "id": "B4GA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWP8", "type": "external" } ], "mass": 47384.0, "length": 415, "protein_name": "Beta-1,4-glucuronyltransferase 1", "gene_name": "B4gat1", "organism": "Mouse", "refseq_name": "beta-1,4-glucuronyltransferase 1", "refseq_ac": [ { "id": "NP_780592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780592", "type": "external" } ], "gene_names_uniprotkb": "B4gat1; B3gnt1; B3gnt6", "gene_names_refseq": "1500032M01Rik; B3gnt1; B3gnt6; B4gat1; BETA3GNT1; iGAT; iGNT", "protein_names_uniprotkb": "Beta-1,4-glucuronyltransferase 1; 2.4.1.-; I-beta-1,3-N-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; iGnT", "protein_names_refseq": "I-beta-1,3-N-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; beta-1,4-glucuronyltransferase 1; poly-N-acetyllactosamine extension enzyme", "tax_id": 10090, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); congenital muscular dystrophy-dystroglycanopathy type A13 (Disease Ontology:DOID:0111238)", "pathway": " (mmu:108902); (R-MMU-2022854); (R-MMU-9939291)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18008318;23217742;25279699;25428506;30084848;34428180", "class_list": "glycogene;glycosyltransferase", "function": "A glucuronic acid beta1,4-xylose disaccharide synthesized by B4GAT1 acts as an acceptor primer that can be elongated by LARGE with the ligand-binding heteropolysaccharide. Publication Status: Online-Only, [RefSeq, PubMed]; Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742, PubMed:25279699). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742)., [UniProtKB, PubMed, PubMed]; Impaired sexual behavior in male mice deficient for the beta1-3 N-acetylglucosaminyltransferase-I gene., [RefSeq, PubMed]; This study demonistrated that the axonal guidance defects observed in B3gnt1 mutant mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY43;Q8BJH9;Q99LW7", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.149", "type": "external" }, { "id": "2.4.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.146", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0007411 axon guidance;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BWP8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWL2-1", "uniprot_id": [ { "id": "CASZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWL2", "type": "external" } ], "mass": 191188.0, "length": 1761, "protein_name": "Zinc finger protein castor homolog 1", "gene_name": "Casz1", "organism": "Mouse", "refseq_name": "zinc finger protein castor homolog 1 isoform 2", "refseq_ac": [ { "id": "NP_081471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081471", "type": "external" } ], "gene_names_uniprotkb": "Casz1; Cst; D4Ertd432e; Kiaa3026", "gene_names_refseq": "2410019P08Rik; Casz1; Cst; D4Ertd432e", "protein_names_uniprotkb": "Zinc finger protein castor homolog 1; Castor-related protein", "protein_names_refseq": "castor homolog 1, zinc finger; castor-related protein; zinc finger protein castor homolog 1 isoform 2; zinc finger protein castor homolog 1", "tax_id": 10090, "disease": "chromosome 1p36 deletion syndrome (Disease Ontology:DOID:0060410)", "pathway": " (mmu:69743)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12351199;16631614;21183079;21750661;29237092;30084848;34428180", "class_list": "", "function": "Report the expression pattern of a murine Castor related gene (Cst) during embryogenesis [cst], [RefSeq, PubMed]; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A8A1;Q69Z25", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:1902870 negative regulation of amacrine cell differentiation;GO:0006351 DNA-templated transcription;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CWL2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8S9-1", "uniprot_id": [ { "id": "BOLA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8S9", "type": "external" } ], "mass": 14379.0, "length": 137, "protein_name": "BolA-like protein 1", "gene_name": "Bola1", "organism": "Mouse", "refseq_name": "bolA-like protein 1", "refseq_ac": [ { "id": "NP_081251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081251", "type": "external" } ], "gene_names_uniprotkb": "Bola1", "gene_names_refseq": "1810037G04Rik; Bola1", "protein_names_uniprotkb": "BolA-like protein 1", "protein_names_refseq": "bolA-like 1; bolA-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69168)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;28528544;31219806", "class_list": "", "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYP6-1", "uniprot_id": [ { "id": "AZI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYP6", "type": "external" } ], "mass": 46091.0, "length": 405, "protein_name": "5-azacytidine-induced protein 2", "gene_name": "Azi2", "organism": "Mouse", "refseq_name": "5-azacytidine-induced protein 2 isoform b", "refseq_ac": [ { "id": "NP_001041611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041611", "type": "external" } ], "gene_names_uniprotkb": "Azi2; Az2; Nap1; Tbkp2", "gene_names_refseq": "AZ2; Azi2; Nap1", "protein_names_uniprotkb": "5-azacytidine-induced protein 2; NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; Nap1", "protein_names_refseq": "5-azacytidine-induced protein 2 isoform b; 5-azacytidine-induced protein 2; NF-kappa-B-activating kinase-associated protein 1; nak-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27215)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10580148;17568778;21750661;22539786;23610142;35595469", "class_list": "", "function": "AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs., [RefSeq, PubMed]; AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia., [RefSeq, PubMed]; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIN1;Q3V3R2;Q9CUI5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0042110 T cell activation;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0097028 dendritic cell differentiation;GO:0044565 dendritic cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QYP6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54784-1", "uniprot_id": [ { "id": "DAPK3_MOUSE", "url": "https://www.uniprot.org/uniprot/O54784", "type": "external" } ], "mass": 51422.0, "length": 448, "protein_name": "Death-associated protein kinase 3", "gene_name": "Dapk3", "organism": "Mouse", "refseq_name": "death-associated protein kinase 3 isoform b", "refseq_ac": [ { "id": "NP_001177402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177402", "type": "external" } ], "gene_names_uniprotkb": "Dapk3; Zipk", "gene_names_refseq": "Dapk3; ZIPK; dlk", "protein_names_uniprotkb": "Death-associated protein kinase 3; 2.7.11.1; DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; ZIP-kinase", "protein_names_refseq": "DAP kinase 3; DAP-like kinase; MYPT1 kinase; ZIP-kinase; death-associated kinase 3; death-associated protein kinase 3 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:13144)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12917339;15096528;16219639;16325270;18515077;20854903;21454679;21750661;23071094;25428506;26117336;30084848;31180722;33767426;38252666;9118998;9488481", "class_list": "", "function": "DAPK3 plays a central role in preventing miR-17/miR-20a depletion-induced genome instability and in miR-17/miR-20a overexpression-triggered tumor formation., [RefSeq, PubMed]; Role of ZIP kinase in development of myofibroblast differentiation from HPMCs., [RefSeq, PubMed]; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR (By similarity). Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis (By similarity). Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The induced deletion of Zipk significantly inhibited ischemia-reperfusion-induced blood-brain barrier dysfunction and neuronal injuries from middle cerebral artery occlusion and reperfusion, as evidenced by reduced infarct and edema volume, attenuated Evans blue dye leakage, and improved neuronal behavior., [RefSeq, PubMed]; The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O54784-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPM0-1", "uniprot_id": [ { "id": "DAAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPM0", "type": "external" } ], "mass": 123370.0, "length": 1077, "protein_name": "Disheveled-associated activator of morphogenesis 1", "gene_name": "Daam1", "organism": "Mouse", "refseq_name": "disheveled-associated activator of morphogenesis 1 isoform b", "refseq_ac": [ { "id": "NP_001273381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273381", "type": "external" } ], "gene_names_uniprotkb": "Daam1", "gene_names_refseq": "Daam1", "protein_names_uniprotkb": "Disheveled-associated activator of morphogenesis 1", "protein_names_refseq": "disheveled-associated activator of morphogenesis 1 isoform b", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:208846); (R-MMU-4086400); (R-MMU-5663220); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15464228;15533824;16393994;18299400;21183079;26526197;28284839;31219806;33082334;33300544;34428180;35820727;37189369;37828378", "class_list": "", "function": "Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (PubMed:26526197). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development., [RefSeq, PubMed]; Involved in pivotal steps in neuronal cell differentiation and movement, [RefSeq, PubMed]; WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHB4;Q6DFY0;Q6TAB8;Q80Y68;Q9CQQ2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0045202 synapse", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0099140 presynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BPM0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61793-1", "uniprot_id": [ { "id": "LPAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61793", "type": "external" } ], "mass": 41119.0, "length": 364, "protein_name": "Lysophosphatidic acid receptor 1", "gene_name": "Lpar1", "organism": "Mouse", "refseq_name": "lysophosphatidic acid receptor 1 isoform 2", "refseq_ac": [ { "id": "NP_001277415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277415", "type": "external" } ], "gene_names_uniprotkb": "Lpar1; Edg2; Gpcr26; Lpa1; Vzg1", "gene_names_refseq": "Edg2; Gpcr26; Kdt2; Lpar1; lpA1; vzg-1", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2; Rec1.3; VZG-1", "protein_names_refseq": "G-protein coupled receptor 26; LPA receptor 1; endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; lysophosphatidic acid receptor 1 isoform 2; lysophosphatidic acid receptor Edg-2; rec1.3", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14745); (R-MMU-416476); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;11040035;11087877;11093753;12181339;12215548;15195086;17656621;17692995;18066075;18157949;18708146;19689455;20358347;21183079;21569876;21750661;21821728;23478264;25226845;25732591;38712822;8922387;9013780;9600933;9721207", "class_list": "", "function": "CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA) (PubMed:11087877, PubMed:18066075). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins (PubMed:11040035, PubMed:18066075, PubMed:18157949, PubMed:23478264, PubMed:8922387, PubMed:9600933). Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11040035, PubMed:12215548). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:12215548). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:11040035, PubMed:12215548, PubMed:23478264). Signaling mediates activation of down-stream MAP kinases (PubMed:11040035). Contributes to the regulation of cell shape (PubMed:11040035, PubMed:11087877, PubMed:8922387, PubMed:9600933). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:11040035, PubMed:12181339, PubMed:9600933). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:12215548, PubMed:9600933). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (PubMed:23478264). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:11087877, PubMed:18066075, PubMed:23478264). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14 (PubMed:21821728). Promotes cell proliferation in response to LPA (PubMed:11087877, PubMed:12215548, PubMed:17692995, PubMed:18157949, PubMed:23478264, PubMed:9600933). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (By similarity). Required for normal skeleton development (PubMed:21569876). May play a role in osteoblast differentiation (PubMed:21569876). Required for normal brain development (PubMed:17656621, PubMed:18708146). Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus (PubMed:18708146). Plays a role in pain perception and in the initiation of neuropathic pain (PubMed:15195086, PubMed:19689455)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AMJ2;O88584;P56487;P70420;Q61130", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0001965 G-protein alpha-subunit binding;GO:0030165 PDZ domain binding;GO:0070915 lysophosphatidic acid receptor activity;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P61793-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811U4-1", "uniprot_id": [ { "id": "MFN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811U4", "type": "external" } ], "mass": 83726.0, "length": 741, "protein_name": "Mitofusin-1", "gene_name": "Mfn1", "organism": "Mouse", "refseq_name": "mitofusin-1", "refseq_ac": [ { "id": "NP_077162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077162", "type": "external" } ], "gene_names_uniprotkb": "Mfn1", "gene_names_refseq": "2310002F04Rik; 6330416C07Rik; D3Ertd265e; HR2; Mfn1; mKIAA4032", "protein_names_uniprotkb": "Mitofusin-1; 3.6.5.-; Transmembrane GTPase MFN1", "protein_names_refseq": "mitofusin-1; transmembrane GTPase MFN1", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); dental fluorosis (Disease Ontology:DOID:13711); primary pulmonary hypertension (Disease Ontology:DOID:14557); status epilepticus (Disease Ontology:DOID:1824); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:67414); (R-MMU-5205685); (R-MMU-9013419); (R-MMU-983231)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11950885;12527753;12759376;15297672;15899901;21750661;23620051;23921378;24513856;25428506;30084848;34428180", "class_list": "", "function": "Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:15297672, PubMed:23921378, PubMed:24513856). Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains (PubMed:15297672). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12527753). Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; OPA1, Mfn1 and Mfn2 have roles in mitochondrial fusion, cell growth, mitochondrial membrane potential, and cellular respiration, [RefSeq, PubMed]; Results suggest that the heptad repeat region (HR2) of mfn1 functions as a mitochondrial tether before fusion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URC4;Q811D5;Q8CEY6;Q99M10;Q9D395", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0098799 outer mitochondrial membrane protein complex", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0007005 mitochondrion organization;GO:0010918 positive regulation of mitochondrial membrane potential;GO:0008053 mitochondrial fusion;GO:0046039 GTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q811U4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U63-1", "uniprot_id": [ { "id": "MFN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U63", "type": "external" } ], "mass": 86188.0, "length": 757, "protein_name": "Mitofusin-2", "gene_name": "Mfn2", "organism": "Mouse", "refseq_name": "mitofusin-2", "refseq_ac": [ { "id": "NP_001272849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272849", "type": "external" } ], "gene_names_uniprotkb": "Mfn2; Kiaa0214; Marf", "gene_names_refseq": "D630023P19Rik; Fzo; Mfn2", "protein_names_uniprotkb": "Mitofusin-2; 3.6.5.-; HSG protein; Hypertension-related protein 1; Mitochondrial assembly regulatory factor; Transmembrane GTPase MFN2", "protein_names_refseq": "HSG protein; hypertension related protein 1; mitochondrial assembly regulatory factor; mitofusin-2; transmembrane GTPase MFN2", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); carotid stenosis (Disease Ontology:DOID:13001); multiple symmetric lipomatosis (Disease Ontology:DOID:14116); primary pulmonary hypertension (Disease Ontology:DOID:14557); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary fibrosis (Disease Ontology:DOID:3770); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:170731); (R-MMU-5205685); (R-MMU-9013419); (R-MMU-983231)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11950885;12527753;12598526;15297672;15322553;21183079;21750661;23620051;23921378;23921556;24513856;29674596;33300544;34428180", "class_list": "", "function": "Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23620051, PubMed:23921378). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Results suggest that the heptad repeat region (HR2) of mfn1 functions as a mitochondrial tether before fusion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7Y7;A8Y5E4;Q3V3B8;Q80WP4;Q80XK3;Q8BHF0;Q8BKV5;Q8R535;Q923X2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0060299 negative regulation of sarcomere organization;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:2000866 positive regulation of estradiol secretion;GO:0046580 negative regulation of Ras protein signal transduction;GO:2000386 positive regulation of ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80U63-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AWP8-1", "uniprot_id": [ { "id": "ARGAL_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AWP8", "type": "external" } ], "mass": 139987.0, "length": 1280, "protein_name": "Rho guanine nucleotide exchange factor 10-like protein", "gene_name": "Arhgef10l", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 10-like protein isoform b", "refseq_ac": [ { "id": "NP_001106193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193", "type": "external" } ], "gene_names_uniprotkb": "Arhgef10l; Kiaa1626", "gene_names_refseq": "2810441C07Rik; Arhgef10l", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 10-like protein; GrinchGEF", "protein_names_refseq": "GrinchGEF; Rho guanine nucleotide exchange factor (GEF) 10-like; rho guanine nucleotide exchange factor 10-like protein isoform b; rho guanine nucleotide exchange factor 10-like protein", "tax_id": 10090, "disease": "ovarian serous carcinoma (Disease Ontology:DOID:0050933); ovarian endometrial cancer (Disease Ontology:DOID:6212)", "pathway": " (mmu:72754); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "17947660;21750661;25428506;30084848;31219806;34418053;34428180;36210013;36647951", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC., [UniProtKB, UniProtKB, UniProtKB]; Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AWP5;A2AWP9;A2AWQ0;A2AWQ1;Q6PCQ2;Q6ZPL3;Q8C1A1;Q8VDH5", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0032933 SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A2AWP8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4I3-1", "uniprot_id": [ { "id": "ARHG6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4I3", "type": "external" } ], "mass": 87051.0, "length": 771, "protein_name": "Rho guanine nucleotide exchange factor 6", "gene_name": "Arhgef6", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 6 isoform 1", "refseq_ac": [ { "id": "NP_690014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690014", "type": "external" } ], "gene_names_uniprotkb": "Arhgef6", "gene_names_refseq": "1600028C08Rik; 1700038J06Rik; 4930592P22Rik; Arhgef6; alpha-PIX", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 6; Alpha-PIX; Rac/Cdc42 guanine nucleotide exchange factor 6", "protein_names_refseq": "Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; alpha PIX Rho GTPase guanine nucleotide exchange factor; rho guanine nucleotide exchange factor 6 isoform 1; rho guanine nucleotide exchange factor 6", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:73341); (R-MMU-193648); (R-MMU-416482); (R-MMU-446388); (R-MMU-8964616); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013420)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "12063400;17105769;17114649;17242355;18299400;18325335;19144319;21183079;21750661;25605945;30059200;30084848;33527537;34428180;36414417", "class_list": "", "function": "ARHGEF6 is localized in dendritic spines where it contributes to regulate dendritic spine morphogenesis., [RefSeq, PubMed]; Acts as a RAC1 guanine nucleotide exchange factor (GEF)., [UniProtKB]; Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence., [RefSeq, PubMed]; Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs., [RefSeq, PubMed]; The mouse Arhgef6 gene: cDNA sequence, expression analysis, and X chromosome assignment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9V4", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0030027 lamellipodium;GO:0042995 cell projection", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K4I3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0K7-1", "uniprot_id": [ { "id": "AT2B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0K7", "type": "external" } ], "mass": 132588.0, "length": 1198, "protein_name": "Plasma membrane calcium-transporting ATPase 2", "gene_name": "Atp2b2", "organism": "Mouse", "refseq_name": "plasma membrane calcium-transporting ATPase 2 isoform 1", "refseq_ac": [ { "id": "NP_001031761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001031761", "type": "external" } ], "gene_names_uniprotkb": "Atp2b2; Pmca2", "gene_names_refseq": "Atp2b2; D6Abb2e; Gena300; PMCA2; Tmy; dfw; jog; wms; wri", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 2; 7.2.2.10; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2", "protein_names_refseq": "deaf waddler; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 2 isoform 1; plasma membrane calcium-transporting ATPase 2; wriggle", "tax_id": 10090, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); autosomal dominant nonsyndromic deafness 82 (Disease Ontology:DOID:0070603); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:11941); (R-MMU-418359); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11985881;12209837;15302868;17234811;17409239;20083513;21183079;21750661;25428506;25605945;30084848;30779550;32848054;33300544;34428180;37675773;40836084;9668038;9697703", "class_list": "", "function": "ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038, PubMed:40836084). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:40836084). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PubMed:9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; ATP2B2 de novo variants as a cause of variable neurodevelopmental disorders that feature dystonia, ataxia, intellectual disability, behavioral symptoms, and seizures., [RefSeq, PubMed]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O88863", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0050808 synapse organization;GO:0050885 neuromuscular process controlling balance;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9R0K7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8R3-1", "uniprot_id": [ { "id": "ANK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8R3", "type": "external" } ], "mass": 426261.0, "length": 3898, "protein_name": "Ankyrin-2", "gene_name": "Ank2", "organism": "Mouse", "refseq_name": "ankyrin-2 isoform 3", "refseq_ac": [ { "id": "NP_001029340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029340", "type": "external" } ], "gene_names_uniprotkb": "Ank2; AnkB", "gene_names_refseq": "100043364; Ank-2; Ank2; Gm4392", "protein_names_uniprotkb": "Ankyrin-2; ANK-2; Ankyrin-B; Brain ankyrin", "protein_names_refseq": "ankyrin-2 isoform 3; ankyrin-B", "tax_id": 10090, "disease": "sinoatrial node disease (Disease Ontology:DOID:0050824); atrial fibrillation (Disease Ontology:DOID:0060224); ankyrin-B-related cardiac arrhythmia (Disease Ontology:DOID:0111700); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); autistic disorder (Disease Ontology:DOID:12849); sick sinus syndrome (Disease Ontology:DOID:13884); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:109676)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;12571597;15262991;16452087;17940615;18034455;19007774;19109891;21183079;21745462;21750661;22517741;22645316;22872234;27718357;32848054;33300544;34203471;34428180;34678516;35820727;35822049;37507081;38290518;40021952;40885482;8253844", "class_list": "", "function": "Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites., [RefSeq, PubMed]; Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (PubMed:19109891). In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites (PubMed:12571597). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:15262991). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (PubMed:19007774). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 53, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 10, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM62;Q3V2X0;Q6PCN2;Q80ZZ7;Q8BNC1;Q8C445;Q8CCV0", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0010628 positive regulation of gene expression;GO:0015031 protein transport;GO:0072659 protein localization to plasma membrane;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q8C8R3-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z206-1", "uniprot_id": [ { "id": "ARHG8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z206", "type": "external" } ], "mass": 67734.0, "length": 595, "protein_name": "Neuroepithelial cell-transforming gene 1 protein", "gene_name": "Net1", "organism": "Mouse", "refseq_name": "neuroepithelial cell-transforming gene 1 protein isoform 2", "refseq_ac": [ { "id": "NP_001040624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040624", "type": "external" } ], "gene_names_uniprotkb": "Net1; Arhgef8", "gene_names_refseq": "Net1a; Net1; mNET1", "protein_names_uniprotkb": "Neuroepithelial cell-transforming gene 1 protein; Rho guanine nucleotide exchange factor 8", "protein_names_refseq": "Net1 homolog; guanine nucleotide regulatory protein (oncogene); neuroepithelial cell-transforming gene 1 protein isoform 2; rho guanine nucleotide exchange factor 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:56349); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "11350080;11839749;19144319;21750661;34428180;38169395;9535835;9670022", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death., [UniProtKB, PubMed]; NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4I0;Q9Z1L7", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0043547 positive regulation of GTPase activity;GO:0070301 cellular response to hydrogen peroxide;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z206-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBR4-1", "uniprot_id": [ { "id": "APBB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBR4", "type": "external" } ], "mass": 83201.0, "length": 760, "protein_name": "Amyloid beta precursor protein binding family B member 2", "gene_name": "Apbb2", "organism": "Mouse", "refseq_name": "amyloid beta precursor protein binding family B member 2 isoform 3", "refseq_ac": [ { "id": "NP_001188343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188343", "type": "external" } ], "gene_names_uniprotkb": "Apbb2; Fe65l1; Fe65l", "gene_names_refseq": "2310007D03Rik; Apbb2; FE65L1; Rirl1; TR2L; Zfra", "protein_names_uniprotkb": "Amyloid beta precursor protein binding family B member 2; Amyloid-beta (A4) precursor protein-binding family B member 2; Protein Fe65-like 1", "protein_names_refseq": "amyloid beta (A4) precursor protein-binding, family B, member 2; amyloid beta precursor protein binding family B member 2 isoform 3; protein Fe65-like 1; zinc finger-like protein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); cognitive disorder (Disease Ontology:DOID:1561)", "pathway": " (mmu:11787)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18650440;21183079;21750661;25428506;25757569;27734846;30084848;30779550;34203471;34428180;35820727;36498839;37828378", "class_list": "", "function": "Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency., [RefSeq, PubMed]; Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (PubMed:25757569, PubMed:27734846). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (PubMed:27734846). Activates transcription of APP (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; These data demonstrate a role for FE65 proteins at central and peripheral synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Zfra Inhibits the TRAPPC6ADelta-Initiated Pathway of Neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6DFX8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006939 smooth muscle contraction;GO:0030198 extracellular matrix organization;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9DBR4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQW7-1", "uniprot_id": [ { "id": "COA8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQW7", "type": "external" } ], "mass": 22715.0, "length": 192, "protein_name": "Cytochrome c oxidase assembly factor 8", "gene_name": "Coa8", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly factor 8 isoform 1", "refseq_ac": [ { "id": "NP_001156860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156860", "type": "external" } ], "gene_names_uniprotkb": "Coa8; 2810002N01Rik; Apop1; Apopt1", "gene_names_refseq": "1700081D05Rik; 2810002N01Rik; Apop-1; Apop1; Apopt1; Coa8", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 8; APOP-1; Apoptogenic protein 1, mitochondrial; COA8", "protein_names_refseq": "UPF0671 protein C14orf153 homolog; apoptogenic protein 1, mitochondrial; apoptogenic, mitochondrial 1; cytochrome c oxidase assembly factor 8 isoform 1", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 17 (Disease Ontology:DOID:0070502)", "pathway": " (mmu:68020)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16782708;18977203;21750661;30552096", "class_list": "", "function": "Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain., [UniProtKB, PubMed]; The authors generated an Apopt1 knockout mouse model which shows impaired motor skills, e.g., decreased motor coordination and endurance, associated with reduced COX activity and levels in multiple tissues., [RefSeq, PubMed]; These data indicate that the inhibition of Apop-1-induced death by IGF-1 is mediated by the activation of the PI3K/Akt signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099617 matrix side of mitochondrial inner membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0000302 response to reactive oxygen species;GO:0097193 intrinsic apoptotic signaling pathway;GO:1904960 positive regulation of cytochrome-c oxidase activity;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1C7-1", "uniprot_id": [ { "id": "PR40A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1C7", "type": "external" } ], "mass": 108481.0, "length": 953, "protein_name": "Pre-mRNA-processing factor 40 homolog A", "gene_name": "Prpf40a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prpf40a; Fbp11; Fnbp3", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-mRNA-processing factor 40 homolog A; FBP-11; Formin-binding protein 11; Formin-binding protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:56194); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "14697212;16391387;19144319;21183079;21750661;22645316;23806337;24129315;25428506;26495903;28528544;30084848;30779550;31219806;31599954;34428180;34887587;36210013;39627609;40997131;8605874;9171351", "class_list": "", "function": "Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61049;Q8BQ76;Q8BRW4;Q8C2U1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0016477 cell migration;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0000398 mRNA splicing, via spliceosome;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9R1C7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBT9-1", "uniprot_id": [ { "id": "ASPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBT9", "type": "external" } ], "mass": 59796.0, "length": 550, "protein_name": "Tether containing UBX domain for GLUT4", "gene_name": "Aspscr1", "organism": "Mouse", "refseq_name": "tether containing UBX domain for GLUT4 isoform 3", "refseq_ac": [ { "id": "NP_001157696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157696", "type": "external" } ], "gene_names_uniprotkb": "Aspscr1; Tug", "gene_names_refseq": "1190006K01Rik; ASPCR1; ASPC; ASPL; ASPS; Aspscr1; RCC17; TUG", "protein_names_uniprotkb": "Tether containing UBX domain for GLUT4; Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog", "protein_names_refseq": "alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog; alveolar soft part sarcoma chromosome region, candidate 1; tether containing UBX domain for GLUT4 isoform 3; tether containing UBX domain for GLUT4; tether, containing a UBX domain, for GLUT4", "tax_id": 10090, "disease": "alveolar soft part sarcoma (Disease Ontology:DOID:4239)", "pathway": " (mmu:68938)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14562105;15345747;16501224;17202135;21183079;21750661;30084848;31219806;32698137;34428180", "class_list": "", "function": "Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface., [UniProtKB, PubMed]; Insulin-stimulated dissociation of TUG and GLUT4 as an important action by which insulin stimulates glucose uptake., [RefSeq, PubMed]; TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes., [RefSeq, PubMed]; TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ABZ7;A2AC06;Q3UKD1;Q6V7K5;Q9CT64", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0046324 regulation of D-glucose import;GO:0042593 glucose homeostasis;GO:0031401 positive regulation of protein modification process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VBT9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YI0-1", "uniprot_id": [ { "id": "ARLY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YI0", "type": "external" } ], "mass": 51739.0, "length": 464, "protein_name": "Argininosuccinate lyase", "gene_name": "Asl", "organism": "Mouse", "refseq_name": "argininosuccinate lyase", "refseq_ac": [ { "id": "NP_598529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598529", "type": "external" } ], "gene_names_uniprotkb": "Asl", "gene_names_refseq": "2510006M18Rik; ASAL; Asl", "protein_names_uniprotkb": "Argininosuccinate lyase; 4.3.2.1; ASAL; Arginosuccinase", "protein_names_refseq": "argininosuccinate lyase; arginosuccinase", "tax_id": 10090, "disease": "argininosuccinic aciduria (Disease Ontology:DOID:14755); hepatocellular carcinoma (Disease Ontology:DOID:684); amino acid metabolic disorder (Disease Ontology:DOID:9252); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:109900); (R-MMU-70635)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21750661;22081021;23806337;34428180;36270249;37453647;37490345;37738569;37828378", "class_list": "", "function": "Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide-mediated dysregulation of claudin expression. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Nitric oxide is required for lung alveolarization revealed by deficiency of argininosuccinate lyase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFA2", "ec_number_list": [ { "id": "4.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004056 argininosuccinate lyase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0007626 locomotory behavior;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0009791 post-embryonic development;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91YI0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCB4-1", "uniprot_id": [ { "id": "ARP21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCB4", "type": "external" } ], "mass": 88567.0, "length": 807, "protein_name": "cAMP-regulated phosphoprotein 21", "gene_name": "Arpp21", "organism": "Mouse", "refseq_name": "cAMP-regulated phosphoprotein 21 isoform 1", "refseq_ac": [ { "id": "NP_001171086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171086", "type": "external" } ], "gene_names_uniprotkb": "Arpp21; Pnpla2; Rcs; Tarpp", "gene_names_refseq": "0710001E13Rik; ARPP-21; Arpp21; D9Bwg1012e; R3hdm3; Tarpp", "protein_names_uniprotkb": "cAMP-regulated phosphoprotein 21; ARPP-21; Regulator of calmodulin signaling; Thymocyte cAMP-regulated phosphoprotein", "protein_names_refseq": "cAMP-regulated phosphoprotein 21 isoform 1; cAMP-regulated phosphoprotein 21; protein phosphatase 1, regulatory (inhibitory) subunit 1C; regulator of calmodulin signaling; thymocyte ARPP; thymocyte cAMP-regulated phosphoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74100)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10854908;11298339;15096520;15499021;21183079;21750661;38467629", "class_list": "", "function": "CARM1 plays a significant role in promoting the differentiation of early thymocyte progenitors, possibly through its direct action on TARPP., [RefSeq, PubMed]; May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons., [UniProtKB, PubMed]; The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Erratum:[Nat Commun. 2024 Aug 5;15(1):6632. doi: 10.1038/s41467-024-50610-8. PMID: 39103338] Publication Status: Online-Only, [RefSeq, PubMed]; Through a molecular mechanism that amplifies GPCR- & PKA-mediated signaling & attenuates GPCR- & PP2B-mediated signaling, RCS (ARPP-21) synergistically increases phosphorylation of key proteins whose phosphorylation is regulated by PKA and PP2B [RCS], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1A561;Q3UUU8;Q7TS83;Q8BLD1;Q8BWM1;Q8C018;Q8C038;Q8C0Y6;Q91Y59", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0003730 mRNA 3'-UTR binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0030154 cell differentiation;GO:0034605 cellular response to heat;GO:0050852 T cell receptor signaling pathway;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DCB4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35585-1", "uniprot_id": [ { "id": "AP1M1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35585", "type": "external" } ], "mass": 48543.0, "length": 423, "protein_name": "AP-1 complex subunit mu-1", "gene_name": "Ap1m1", "organism": "Mouse", "refseq_name": "AP-1 complex subunit mu-1", "refseq_ac": [ { "id": "NP_031482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031482", "type": "external" } ], "gene_names_uniprotkb": "Ap1m1; Cltnm", "gene_names_refseq": "AP47; Adtm1A; Ap1m1; Cltnm; mu1A", "protein_names_uniprotkb": "AP-1 complex subunit mu-1; AP-mu chain family member mu1A; Adaptor protein complex AP-1 subunit mu-1; Adaptor-related protein complex 1 subunit mu-1; Clathrin assembly protein complex 1 mu-1 medium chain 1; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu-adaptin 1; Mu1A-adaptin", "protein_names_refseq": "AP-1 complex subunit mu-1; AP-mu chain family member mu1A; adapter-related protein complex 1 subunit mu-1; adaptor protein complex AP-1 mu-1 subunit; adaptor-related protein complex 1 mu-1 subunit; clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1 mu-1 medium chain 1; clathrin coat assembly protein AP47; clathrin coat-associated protein AP47; golgi adaptor HA1/AP1 adaptin mu-1 subunit; mu-adaptin 1; mu1A-adaptin", "tax_id": 10090, "disease": "", "pathway": " (mmu:11767); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10640811;17242355;1761056;21183079;21750661;25428506;27802388;28235798;30084848;37507081", "class_list": "", "function": "L-selectin is transported constitutively by the AP-1 complex, leading to the formation of a trans-Golgi network reserve pool; phosphorylation of the L-selectin tail blocks AP-1-dependent retrograde transport of L-selectin, [RefSeq, PubMed]; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0045202 synapse;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0060155 platelet dense granule organization;GO:0016192 vesicle-mediated transport;GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P35585-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61548-1", "uniprot_id": [ { "id": "AP180_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61548", "type": "external" } ], "mass": 91851.0, "length": 901, "protein_name": "Clathrin coat assembly protein AP180", "gene_name": "Snap91", "organism": "Mouse", "refseq_name": "clathrin coat assembly protein AP180 isoform 3", "refseq_ac": [ { "id": "NP_001264911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264911", "type": "external" } ], "gene_names_uniprotkb": "Snap91", "gene_names_refseq": "91kDa; AP180; F1-20; Snap91; mKIAA0656", "protein_names_uniprotkb": "Clathrin coat assembly protein AP180; 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180; Phosphoprotein F1-20", "protein_names_refseq": "91 kDa synaptosomal-associated protein; clathrin coat assembly protein AP180 isoform 3; clathrin coat assembly protein AP180; clathrin coat-associated protein AP180; phosphoprotein F1-20; synaptosomal-associated protein, 91 kDa", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:20616); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;15345747;1607933;18299400;19224205;20173027;21183079;21750661;22517741;22645316;22826440;24129315;26192747;30059200;31843760;32848054;33300544;34678516;35820727;35822049;36852467;40885482", "class_list": "", "function": "AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells. Publication Status: Online-Only, [RefSeq, PubMed]; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q61547;Q8K0D4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0042169 SH2 domain binding;GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density", "go_biological_process": "GO:1905445 positive regulation of clathrin coat assembly;GO:0051223 regulation of protein transport;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:2000331 regulation of terminal button organization;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q61548-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U0L2-1", "uniprot_id": [ { "id": "AN33B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U0L2", "type": "external" } ], "mass": 53203.0, "length": 486, "protein_name": "Ankyrin repeat domain-containing protein 33B", "gene_name": "Ankrd33b", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 33B isoform 3", "refseq_ac": [ { "id": "NP_001157913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157913", "type": "external" } ], "gene_names_uniprotkb": "Ankrd33b", "gene_names_refseq": "0610012A05Rik; 3021401C12Rik; 5730557B15Rik; Ankrd33b", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 33B", "protein_names_refseq": "ankyrin repeat domain-containing protein 33B isoform 3; ankyrin repeat domain-containing protein 33B", "tax_id": 10090, "disease": "", "pathway": " (mmu:67434)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJA8;Q9CYB2;Q9CZ88;Q9DCQ8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U0L2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHI0-1", "uniprot_id": [ { "id": "CCSE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHI0", "type": "external" } ], "mass": 92932.0, "length": 833, "protein_name": "Serine-rich coiled-coil domain-containing protein 2", "gene_name": "Ccser2", "organism": "Mouse", "refseq_name": "serine-rich coiled-coil domain-containing protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001334431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334431", "type": "external" } ], "gene_names_uniprotkb": "Ccser2; Fam190b; Gcap14; Kiaa1128", "gene_names_refseq": "1700012P13Rik; 2900054P12Rik; Ccser2; Fam190b; Gcap14", "protein_names_uniprotkb": "Serine-rich coiled-coil domain-containing protein 2; Coiled-coil serine-rich protein 2; Granule cell antiserum positive protein 14; Protein GCAP14", "protein_names_refseq": "coiled-coil serine-rich protein 2; granule cell antiserum positive 14; granule cell antiserum positive protein 14; protein FAM190B; serine-rich coiled-coil domain-containing protein 2 isoform 3; serine-rich coiled-coil domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72972)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;22673506;31219806;36210013;36795749", "class_list": "", "function": "Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment., [RefSeq, PubMed]; Microtubule-binding protein which might play a role in microtubule bundling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RT11;Q2NKY3;Q3TA20;Q6ZPX3;Q9DAD5", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UHI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGK2-1", "uniprot_id": [ { "id": "ARHL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGK2", "type": "external" } ], "mass": 39885.0, "length": 353, "protein_name": "Inactive ADP-ribosyltransferase ARH2", "gene_name": "Adprhl1", "organism": "Mouse", "refseq_name": "inactive ADP-ribosyltransferase ARH2 isoform 1", "refseq_ac": [ { "id": "NP_766338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766338", "type": "external" } ], "gene_names_uniprotkb": "Adprhl1; Arh2", "gene_names_refseq": "Adprhl1; Arh2; D330008N11Rik; Gm34595", "protein_names_uniprotkb": "Inactive ADP-ribosyltransferase ARH2; ADP-ribosylhydrolase-like protein 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1", "protein_names_refseq": "ADP-ribosylhydrolase 2; ADP-ribosylhydrolase-like protein 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1; inactive ADP-ribosyltransferase ARH2 isoform 1; inactive ADP-ribosyltransferase ARH2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234072)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12070318;17075046;21183079;21750661;27217161;32726316;37507081", "class_list": "", "function": "Cardiac Adprhl1 expression is conserved in mammals, with Adprhl1 mRNA detected within embryonic mouse hearts at E11.5 and its expression may depend on the presence of the cardiac transcription factor, Nkx2-5., [RefSeq, PubMed]; Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site. Publication Status: Online-Only, [RefSeq, PubMed]; Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (PubMed:17075046)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4L0", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003875 ADP-ribosylarginine hydrolase activity;GO:0046872 metal ion binding;GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds", "go_cellular_component": "GO:0030017 sarcomere", "go_biological_process": "GO:0055003 cardiac myofibril assembly;GO:0051725 protein de-ADP-ribosylation;GO:0003242 cardiac chamber ballooning", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BGK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZE9-1", "uniprot_id": [ { "id": "BMF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZE9", "type": "external" } ], "mass": 20682.0, "length": 185, "protein_name": "Bcl-2-modifying factor", "gene_name": "Bmf", "organism": "Mouse", "refseq_name": "bcl-2-modifying factor isoform 3", "refseq_ac": [ { "id": "NP_001318150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001318150", "type": "external" } ], "gene_names_uniprotkb": "Bmf", "gene_names_refseq": "Bmf", "protein_names_uniprotkb": "Bcl-2-modifying factor", "protein_names_refseq": "bcl-2-modifying factor isoform 3; bcl-2-modifying factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:171543); (R-MMU-111453); (R-MMU-139910)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11546872;14574334;18462686;19841067;21750661;31093317;31189926;34462553", "class_list": "", "function": "Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim., [RefSeq, PubMed]; May play a role in apoptosis., [UniProtKB]; MiR-29b binds to the 3'-UTR of Bmf. Publication Status: Online-Only, [RefSeq, PubMed]; Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUK0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0001669 acrosomal vesicle;GO:0016459 myosin complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0031334 positive regulation of protein-containing complex assembly;GO:0010507 negative regulation of autophagy;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91ZE9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55017-1", "uniprot_id": [ { "id": "CAC1B_MOUSE", "url": "https://www.uniprot.org/uniprot/O55017", "type": "external" } ], "mass": 261481.0, "length": 2327, "protein_name": "Voltage-dependent N-type calcium channel subunit alpha-1B", "gene_name": "Cacna1b", "organism": "Mouse", "refseq_name": "voltage-dependent N-type calcium channel subunit alpha-1B isoform 1", "refseq_ac": [ { "id": "NP_001035993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035993", "type": "external" } ], "gene_names_uniprotkb": "Cacna1b; Cach5; Cacnl1a5; Cchn1a", "gene_names_refseq": "BIII; Cacna1b; Cav2.2; Cchn1a; alpha(1B)", "protein_names_uniprotkb": "Voltage-dependent N-type calcium channel subunit alpha-1B; BIII; Brain calcium channel III; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2", "protein_names_refseq": "brain calcium channel III; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1; voltage-dependent N-type calcium channel subunit alpha-1B; voltage-gated calcium channel subunit alpha Cav2.2", "tax_id": 10090, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); hereditary ataxia (Disease Ontology:DOID:0050951); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); brain edema (Disease Ontology:DOID:4724); migraine (Disease Ontology:DOID:6364)", "pathway": " (mmu:12287); (R-MMU-112308)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11438518;16452087;17114649;21183079;21750661;22645316;24129315;24709664;34678516;38643253;40885482;8307146", "class_list": "", "function": "Interleukin-1alpha links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q60609", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0051721 protein phosphatase 2A binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043198 dendritic shaft", "go_biological_process": "GO:0007626 locomotory behavior;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0008217 regulation of blood pressure;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O55017-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9C7-1", "uniprot_id": [ { "id": "CC062_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9C7", "type": "external" } ], "mass": 28436.0, "length": 252, "protein_name": "Uncharacterized protein C3orf62 homolog", "gene_name": "1700102P08Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C3orf62 homolog", "refseq_ac": [ { "id": "NP_444446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444446", "type": "external" } ], "gene_names_uniprotkb": "1700102P08Rik", "gene_names_refseq": "1700102P08Rik; Maps", "protein_names_uniprotkb": "Uncharacterized protein C3orf62 homolog", "protein_names_refseq": "uncharacterized protein C3orf62 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:112418)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;31930642", "class_list": "", "function": "Essential for normal spermatogenesis and male fertility., [UniProtKB, PubMed]; The testis-specific gene 1700102P08Rik is essential for male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0D7;Q6P8V6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9C7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES28-1", "uniprot_id": [ { "id": "ARHG7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES28", "type": "external" } ], "mass": 97056.0, "length": 862, "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "Arhgef7", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 7 isoform a", "refseq_ac": [ { "id": "NP_001106989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106989", "type": "external" } ], "gene_names_uniprotkb": "Arhgef7; Kiaa0142; Pak3bp", "gene_names_refseq": "Arhgef7; Cool; PIX; Pak3bp; beta-Pix; betaPix-b; betaPix-c; betaPix; cool-1; mKIAA0142; p85Cool1; p85SPR", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 7; Beta-Pix; PAK-interacting exchange factor beta; p85SPR", "protein_names_refseq": "PAK-interacting exchange factor beta; Pak3 binding protein; Rho guanine nucleotide exchange factor (GEF7); rho guanine nucleotide exchange factor 7 isoform a; rho guanine nucleotide exchange factor 7", "tax_id": 10090, "disease": "cerebrovascular disease (Disease Ontology:DOID:6713)", "pathway": " (mmu:54126); (R-MMU-182971); (R-MMU-193648); (R-MMU-3928664); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013149); (R-MMU-9013406); (R-MMU-9013420); (R-MMU-9013424)", "pathway_count": 10, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10428811;10860822;11266127;12153727;15120616;15345747;16307729;16959763;17093062;17114649;17242355;18325335;19144319;21183079;21750661;22645316;25605945;26495903;30084848;30779550;34428180;34678516;9207241", "class_list": "", "function": "Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08757;Q3UTS5;Q6XPA5;Q6ZQI5;Q8C750;Q91ZZ6;Q9ES27", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0043008 ATP-dependent protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043547 positive regulation of GTPase activity;GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9ES28-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08226-1", "uniprot_id": [ { "id": "APOE_MOUSE", "url": "https://www.uniprot.org/uniprot/P08226", "type": "external" } ], "mass": 35867.0, "length": 311, "protein_name": "Apolipoprotein E", "gene_name": "Apoe", "organism": "Mouse", "refseq_name": "apolipoprotein E precursor", "refseq_ac": [ { "id": "NP_001292748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292748", "type": "external" } ], "gene_names_uniprotkb": "Apoe", "gene_names_refseq": "Apo-E; Apoe", "protein_names_uniprotkb": "Apolipoprotein E; Apo-E", "protein_names_refseq": "apolipoprotein E precursor", "tax_id": 10090, "disease": "primary cutaneous amyloidosis (Disease Ontology:DOID:0050639); glomerulosclerosis (Disease Ontology:DOID:0050851); left ventricular failure (Disease Ontology:DOID:0051064); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); age related macular degeneration 1 (Disease Ontology:DOID:0110014); Alzheimer's disease 2 (Disease Ontology:DOID:0110035); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); sensorineural hearing loss (Disease Ontology:DOID:10003); cholelithiasis (Disease Ontology:DOID:10211); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); membranous glomerulonephritis (Disease Ontology:DOID:10976); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); Lewy body dementia (Disease Ontology:DOID:12217); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); low tension glaucoma (Disease Ontology:DOID:13544); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); gallbladder cancer (Disease Ontology:DOID:3121); hyperlipoproteinemia type III (Disease Ontology:DOID:3145); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); lung carcinoma (Disease Ontology:DOID:3905); sea-blue histiocytosis (Disease Ontology:DOID:4423); macular degeneration (Disease Ontology:DOID:4448); bile duct cancer (Disease Ontology:DOID:4606); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); herpes simplex (Disease Ontology:DOID:8566); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11816); (R-MMU-3000480); (R-MMU-381426); (R-MMU-8957275); (R-MMU-8963888); (R-MMU-8963901); (R-MMU-8964026); (R-MMU-8964058); (R-MMU-975634)", "pathway_count": 9, "publication_count": 20, "publication_id_list": "12569158;1319610;1423598;16876491;1870200;20037584;21183079;21750661;23676495;23812099;2550421;26387950;29516132;34428180;35820727;35984892;36288343;37453647;3865219;39627609", "class_list": "", "function": "APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles (By similarity). Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells (PubMed:23676495)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 65, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005768 endosome", "go_biological_process": "GO:0072359 circulatory system development;GO:0050709 negative regulation of protein secretion;GO:0097006 regulation of plasma lipoprotein particle levels;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P08226-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ASQ1-1", "uniprot_id": [ { "id": "AGRIN_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ASQ1", "type": "external" } ], "mass": 207539.0, "length": 1950, "protein_name": "Agrin", "gene_name": "Agrn", "organism": "Mouse", "refseq_name": "agrin isoform 2", "refseq_ac": [ { "id": "NP_001355955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355955", "type": "external" } ], "gene_names_uniprotkb": "Agrn; Agrin", "gene_names_refseq": "Agrin; Agrn; nmf380", "protein_names_uniprotkb": "Agrin", "protein_names_refseq": "agrin isoform 2", "tax_id": 10090, "disease": "congenital myasthenic syndrome 8 (Disease Ontology:DOID:0110657)", "pathway": " (mmu:11603); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-3000178); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9913351)", "pathway_count": 9, "publication_count": 27, "publication_id_list": "10402191;10581249;11018052;11161480;12796478;16452087;17611272;18230682;19221030;19303856;21037280;21183079;21750661;21885656;21890498;31219806;33300544;35820727;35822049;35984892;36852467;37828378;38387006;38461287;40885482;8653787;9188458", "class_list": "glycogene", "function": "Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation., [RefSeq, PubMed]; Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Depending on alternative splicing and post-translational modifications, it has a role in different processes, including neuromuscular junction formation and maintenance, and regulation of neurite outgrowth (PubMed:10402191, PubMed:11018052, PubMed:12796478, PubMed:17611272, PubMed:19303856, PubMed:21885656, PubMed:8653787). Involved in the positive regulation of cartilage formation through alpha-dystroglycan binding and up-regulation of SOX9 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation (PubMed:8653787, PubMed:10402191). This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This transmembrane agrin (TM-agrin) isoform, the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases (PubMed:17611272, PubMed:19303856)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Isoform 2 and isoform 3: these isoforms lacking the 'z' insert (z0) are muscle-specific, have no AChR clustering ability and may be involved in nervous system endothelial cell differentiation., [UniProtKB]; This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 148, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2ASP9;A2ASQ0;B2RWU1", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0043395 heparan sulfate proteoglycan binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:1902667 regulation of axon guidance;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007009 plasma membrane organization;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "A2ASQ1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000011001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBT6-1", "uniprot_id": [ { "id": "APOBR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBT6", "type": "external" } ], "mass": 102705.0, "length": 942, "protein_name": "Apolipoprotein B receptor", "gene_name": "Apobr", "organism": "Mouse", "refseq_name": "apolipoprotein B receptor", "refseq_ac": [ { "id": "NP_612183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612183", "type": "external" } ], "gene_names_uniprotkb": "Apobr; Apob48r", "gene_names_refseq": "Apob-48r; Apob48r; Apobr", "protein_names_uniprotkb": "Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B48 receptor; apoB-48R", "protein_names_refseq": "apolipoprotein B receptor; apolipoprotein B-100 receptor; apolipoprotein B-48 receptor; apolipoprotein B48 receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:171504); (R-MMU-8964046)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12177162;17192460;19144319;21750661;21913724;26495903;31219806", "class_list": "", "function": "Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030229 very-low-density lipoprotein particle receptor activity;GO:0030228 lipoprotein particle receptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0090077 foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VBT6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N7-1", "uniprot_id": [ { "id": "ARI3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1N7", "type": "external" } ], "mass": 61015.0, "length": 568, "protein_name": "AT-rich interactive domain-containing protein 3B", "gene_name": "Arid3b", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 3B isoform 1", "refseq_ac": [ { "id": "NP_062663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062663", "type": "external" } ], "gene_names_uniprotkb": "Arid3b; Bdp; Dril2", "gene_names_refseq": "Arid3b; Bdp; Dri2", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 3B; ARID domain-containing protein 3B; Bright and dead ringer protein; Bright-like protein", "protein_names_refseq": "ARID domain-containing protein 3B; AT rich interactive domain 3B (BRIGHT-like); AT rich interactive domain 3B (Bright like); AT-rich interactive domain-containing protein 3B isoform 1; AT-rich interactive domain-containing protein 3B; bright and dead ringer gene product homologous protein Bdp; bright and dead ringer protein; bright-like protein; dead ringer homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56380)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10446990;16530748;21750661;24129315;24704276;34428180;36852467", "class_list": "", "function": "The different patterns of ARID3B in normal tissues translate into different roles for ARID3B in carcinomas., [RefSeq, PubMed]; Transcription factor involved in the production of cranial mesenchymal tissues. Favors nuclear targeting of ARID3A., [UniProtKB, PubMed]; Transcription factor., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTG1;Q810L9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z1N7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57780-1", "uniprot_id": [ { "id": "ACTN4_MOUSE", "url": "https://www.uniprot.org/uniprot/P57780", "type": "external" } ], "mass": 104977.0, "length": 912, "protein_name": "Alpha-actinin-4", "gene_name": "Actn4", "organism": "Mouse", "refseq_name": "alpha-actinin-4 isoform 1", "refseq_ac": [ { "id": "NP_068695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068695", "type": "external" } ], "gene_names_uniprotkb": "Actn4", "gene_names_refseq": "Actn4", "protein_names_uniprotkb": "Alpha-actinin-4; Non-muscle alpha-actinin 4", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin-4 isoform 1; alpha-actinin-4; non-muscle alpha-actinin 4", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (mmu:60595); (R-MMU-114608)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10964513;18250455;18332111;21750661;22645316;23806337;24788674;25153642;25605945;26495903;28528544;31219806;33300544;34428180;34887587;36251469;36288343;37453647;37507081;37730132;37828378;39627609", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (PubMed:18332111). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (By similarity). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Mesenchymal beta-catenin signaling affects palatogenesis by regulating alpha-actinin-4 and F-actin., [RefSeq, PubMed]; Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005200 structural constituent of cytoskeleton;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P57780-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5H1-1", "uniprot_id": [ { "id": "ANO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5H1", "type": "external" } ], "mass": 111544.0, "length": 955, "protein_name": "Anoctamin-4", "gene_name": "Ano4", "organism": "Mouse", "refseq_name": "anoctamin-4", "refseq_ac": [ { "id": "NP_001264117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264117", "type": "external" } ], "gene_names_uniprotkb": "Ano4; Tmem16d", "gene_names_refseq": "A330096O15Rik; Ano4; Gm65; Tmem16d", "protein_names_uniprotkb": "Anoctamin-4; Transmembrane protein 16D", "protein_names_refseq": "anoctamin-4; transmembrane protein 16D (eight membrane-spanning domains)", "tax_id": 10090, "disease": "", "pathway": " (mmu:320091); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;20056604;21750661;22075693;22302790;23532839;30084848;30783137;37261917", "class_list": "", "function": "Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. Publication Status: Online-Only, [RefSeq, PubMed]; Anoctamin-4 is a bona fide Ca(2+)-dependent non-selective cation channel. Publication Status: Online-Only, [RefSeq, PubMed]; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA37", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:1902476 chloride transmembrane transport;GO:0061589 calcium activated phosphatidylserine scrambling;GO:0061590 calcium activated phosphatidylcholine scrambling;GO:0061591 calcium activated galactosylceramide scrambling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C5H1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VR2-1", "uniprot_id": [ { "id": "ATPG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VR2", "type": "external" } ], "mass": 32886.0, "length": 298, "protein_name": "ATP synthase F(1) complex subunit gamma, mitochondrial", "gene_name": "Atp5f1c", "organism": "Mouse", "refseq_name": "ATP synthase F(1) complex subunit gamma, mitochondrial isoform a", "refseq_ac": [ { "id": "NP_065640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065640", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1c; Atp5c1", "gene_names_refseq": "1700094F02Rik; Atp5c1; Atp5f1c", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit gamma, mitochondrial; ATP synthase F1 subunit gamma; F-ATPase gamma subunit", "protein_names_refseq": "ATP synthase F(1) complex subunit gamma, mitochondrial isoform a; ATP synthase F(1) complex subunit gamma, mitochondrial; ATP synthase gamma-subunit gene encoding a mitochondrial protein; ATP synthase subunit gamma, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; F-ATPase gamma subunit; F1 gamma", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11949); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316;23576753;23806337;25428506;25605945;28135057;30084848;31599954;32973183;33300544;34428180;35820727;36210013;36288343;37453647;37507081;39627609;39927985", "class_list": "", "function": "Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q91VR2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBF1-1", "uniprot_id": [ { "id": "AL7A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBF1", "type": "external" } ], "mass": 58861.0, "length": 539, "protein_name": "Alpha-aminoadipic semialdehyde dehydrogenase", "gene_name": "Aldh7a1", "organism": "Mouse", "refseq_name": "alpha-aminoadipic semialdehyde dehydrogenase isoform b", "refseq_ac": [ { "id": "NP_001120810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120810", "type": "external" } ], "gene_names_uniprotkb": "Aldh7a1; Ald7a1", "gene_names_refseq": "Aldh7a1; Atq1; D18Wsu181e", "protein_names_uniprotkb": "Alpha-aminoadipic semialdehyde dehydrogenase; 1.2.1.31; 1.2.1.3; 1.2.1.8; Aldehyde dehydrogenase family 7 member A1; Alpha-AASA dehydrogenase; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase", "protein_names_refseq": "P6c dehydrogenase; aldehyde dehydrogenase 7 family, member A1; alpha-AASA dehydrogenase; alpha-aminoadipic semialdehyde dehydrogenase isoform b; alpha-aminoadipic semialdehyde dehydrogenase; antiquitin-1; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease", "tax_id": 10090, "disease": "early-onset vitamin B6-dependent epilepsy 4 (Disease Ontology:DOID:0070519); pyridoxine-dependent epilepsy (Disease Ontology:DOID:0080768); epilepsy (Disease Ontology:DOID:1826); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:110695); (R-MMU-6798163); (R-MMU-71064)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;20207735;21750661;23576753;23806337;31599954;32782141;32848054;32969477;33537098;34428180;37453647;37507081;37828378;40021952;40885482", "class_list": "", "function": "Acts as a key inhibitor of ferroptosis both by generating membrane NADH and decreasing the level of reactive aldehydes. Recruited to plasma membrane in response to ferroptotic stress and phosphorylation by AMPK, generating membrane NADH to support AIFM2/FSP1 activity, an essential ferroptosis suppressor protein. Also directly inhibits ferroptosis by decreasing lipid peroxidation via consumption of reactive aldehydes, such as 4-hydroxynonenal (4-HNE) and malonaldehyde. Also acts as a regulator of cellular energy homeostasis in response to cellular energy stress, such as starvation and hypoxia, by inhibiting COPI-mediated intracellular transport, thereby reducing cellular energy consumption., [UniProtKB, UniProtKB]; Aldehyde dehydrogenase enzyme that mediates important protective effects. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor., [UniProtKB, UniProtKB]; Involved in lysine catabolism in the brain by mediating the conversion of L-aminoadipate-semialdehyde ((S)-2-amino-6-oxohexanoate) to L-2-aminoadipate., [UniProtKB, PubMed]; Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFC7;Q3TVH7;Q3UKT6", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004043 L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity;GO:0008802 betaine-aldehyde dehydrogenase (NAD+) activity;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006554 lysine catabolic process;GO:0097009 energy homeostasis;GO:0008333 endosome to lysosome transport;GO:0019285 glycine betaine biosynthetic process from choline;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9DBF1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K298-1", "uniprot_id": [ { "id": "ANLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K298", "type": "external" } ], "mass": 122794.0, "length": 1121, "protein_name": "Anillin", "gene_name": "Anln", "organism": "Mouse", "refseq_name": "anillin isoform 2", "refseq_ac": [ { "id": "NP_082666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082666", "type": "external" } ], "gene_names_uniprotkb": "Anln", "gene_names_refseq": "1110037A17Rik; 2900037I21Rik; Anln; Scraps", "protein_names_uniprotkb": "Anillin", "protein_names_refseq": "actin-binding protein anillin; anillin isoform 2; anillin, actin binding protein (scraps homolog, Drosophila)", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis 8 (Disease Ontology:DOID:0111133)", "pathway": " (mmu:68743); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15592455;19144319;21183079;21750661;22645316;24788674;25153642;28135057;28528544;30899004;31219806;34887587;36852467", "class_list": "", "function": "Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL79;Q8BLB3;Q8K2N0;Q9CUY0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0030496 midbody;GO:0005826 actomyosin contractile ring", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0002244 hematopoietic progenitor cell differentiation;GO:0090521 podocyte cell migration;GO:1904172 positive regulation of bleb assembly;GO:0000915 actomyosin contractile ring assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8K298-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXK8-1", "uniprot_id": [ { "id": "ASIC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NXK8", "type": "external" } ], "mass": 59668.0, "length": 526, "protein_name": "Acid-sensing ion channel 1", "gene_name": "Asic1", "organism": "Mouse", "refseq_name": "acid-sensing ion channel 1 isoform 2", "refseq_ac": [ { "id": "NP_001276720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276720", "type": "external" } ], "gene_names_uniprotkb": "Asic1; Accn2; Asic; Bnac2", "gene_names_refseq": "ASIC1a; ASIC1b; ASIC; Accn2; Asic1; B530003N02Rik; BNaC2", "protein_names_uniprotkb": "Acid-sensing ion channel 1; ASIC1; Acid-sensing ion channel; Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2", "protein_names_refseq": "acid-sensing (proton-gated) ion channel 1; acid-sensing ion channel 1 isoform 2; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2; degenerin 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:11419); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11988176;12509480;12843249;15369669;15471860;15578512;17060608;17662962;18158916;21036899;21183079;22442073;22553040;38987597", "class_list": "", "function": "Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:11988176, PubMed:12843249, PubMed:15369669, PubMed:17060608). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:15369669). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:15369669). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines (PubMed:15369669, PubMed:17060608). Modulates neuronal activity in the circuits underlying innate fear (PubMed:17662962)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury., [RefSeq, PubMed]; Has high selectivity for sodium ions but is also potentially permeable to other cations including potassium (PubMed:18158916, PubMed:21036899). Could function in cochlear mechanoelectrical transduction (PubMed:18158916)., [UniProtKB, PubMed, PubMed]; Ontogeny of ASIC1 in mouse brain revealed constant levels of expression of ASIC1 protein from embryonic day 12 to postnatal period, indicating early and almost constant level of expression of ASIC1 during brain development., [RefSeq, PubMed]; These results identify ASIC as a key component of acid-activated currents and implicate these currents in processes underlying synaptic plasticity, learning, and memory (ASIC channel)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q50K97", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0022857 transmembrane transporter activity;GO:0015280 ligand-gated sodium channel activity;GO:0022839 monoatomic ion-gated channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007613 memory;GO:0008306 associative learning;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6NXK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0X1-1", "uniprot_id": [ { "id": "AIFM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0X1", "type": "external" } ], "mass": 66765.0, "length": 612, "protein_name": "Apoptosis-inducing factor 1, mitochondrial", "gene_name": "Aifm1", "organism": "Mouse", "refseq_name": "apoptosis-inducing factor 1, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001277293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277293", "type": "external" } ], "gene_names_uniprotkb": "Aifm1; Aif; Pdcd8", "gene_names_refseq": "AIFsh2; AIF; Aifm1; Hq; Pdcd8", "protein_names_uniprotkb": "Apoptosis-inducing factor 1, mitochondrial; 1.6.99.-; Programmed cell death protein 8", "protein_names_refseq": "apoptosis-inducing factor 1, mitochondrial isoform 2; apoptosis-inducing factor 1, mitochondrial; harlequin; programmed cell death protein 8", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); Charcot-Marie-Tooth disease X-linked recessive 4 (Disease Ontology:DOID:0110212); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); combined oxidative phosphorylation deficiency 6 (Disease Ontology:DOID:0111502); X-linked deafness 5 (Disease Ontology:DOID:0111741); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); retinal detachment (Disease Ontology:DOID:5327)", "pathway": " (mmu:26926)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11967568;12114629;16644725;19447115;21467298;21750661;23576753;23806337;26004228;26495903;34428180;34887587;36288343;37453647;37507081;38449065;39927985;9989411", "class_list": "", "function": "AIF translocation into nucleus caused by Aifm1 R450Q mutation: generation and characterization of a mouse model for AUNX1., [RefSeq, PubMed]; Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:12114629, PubMed:21467298, PubMed:9989411). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (PubMed:21467298). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:12114629, PubMed:21467298, PubMed:9989411). Binds to DNA in a sequence-independent manner (PubMed:21467298). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (By similarity). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (By similarity). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:19447115)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1L6K5", "ec_number_list": [ { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0072572 poly-ADP-D-ribose binding;GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0071949 FAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0033108 mitochondrial respiratory chain complex assembly;GO:0006979 response to oxidative stress;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9Z0X1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JII6-1", "uniprot_id": [ { "id": "AK1A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JII6", "type": "external" } ], "mass": 36587.0, "length": 325, "protein_name": "Aldo-keto reductase family 1 member A1", "gene_name": "Akr1a1", "organism": "Mouse", "refseq_name": "aldo-keto reductase family 1 member A1", "refseq_ac": [ { "id": "NP_067448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067448", "type": "external" } ], "gene_names_uniprotkb": "Akr1a1; Akr1a4", "gene_names_refseq": "2610201A18Rik; Akr1a1; Akr1a4", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member A1; 1.1.1.19; 1.1.1.20; 1.1.1.2; 1.1.1.372; 1.1.1.54; 1.6.-.-; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; S-nitroso-CoA reductase; ScorR", "protein_names_refseq": "S-nitroso-CoA reductase; alcohol dehydrogenase; aldehyde reductase; aldo-keto reductase family 1 member A1; aldo-keto reductase family 1, member A4 (aldehyde reductase); glucuronate reductase; glucuronolactone reductase; scorR", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:58810); (R-MMU-156590); (R-MMU-5661270)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10842086;11533224;15769935;20410296;21750661;22820017;23806337;25512491;30487609;31649033;32142766;33549889;34428180;35679914;36288343;37453647;37507081", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:15769935, PubMed:20410296, PubMed:22820017). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:15769935, PubMed:20410296, PubMed:22820017). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:15769935, PubMed:20410296, PubMed:22820017). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:25512491, PubMed:30487609). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (PubMed:30487609). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels., [RefSeq, PubMed]; Genetic ablation of AKR1A activates the PGC-1alpha pathway and spare glucose, which would consequently confer exercise endurance, [RefSeq, PubMed]; The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQI5;Q9CQT8;Q9CT53;Q9D012;Q9D016;Q9D0I7;Q9D0P3", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0047939 L-glucuronate reductase activity;GO:0047956 glycerol dehydrogenase (NADP+) activity;GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0046185 aldehyde catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JII6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922X9-1", "uniprot_id": [ { "id": "ANM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922X9", "type": "external" } ], "mass": 78301.0, "length": 692, "protein_name": "Protein arginine N-methyltransferase 7", "gene_name": "Prmt7", "organism": "Mouse", "refseq_name": "protein arginine N-methyltransferase 7", "refseq_ac": [ { "id": "NP_663379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663379", "type": "external" } ], "gene_names_uniprotkb": "Prmt7; Kiaa1933", "gene_names_refseq": "4933402B05Rik; Prmt7", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 7; 2.1.1.321; Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7", "protein_names_refseq": "[Myelin basic protein]-arginine N-methyltransferase PRMT7; histone-arginine N-methyltransferase PRMT7; protein arginine N-methyltransferase 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:214572); (R-MMU-3214858)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "15699352;16690984;17048991;18299400;18449859;19892989;21750661;24129315;25428506;25428507;25605945;26437029;30084848;30779550;32782141;34428180;38376246;38486105", "class_list": "", "function": "Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity)., [UniProtKB, PubMed]; CTCFL and PRMT7 may play a role in male germline imprinted gene methylation., [RefSeq, PubMed]; PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis., [RefSeq, PubMed]; Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRZ6;Q69Z62;Q6B955;Q6PG80", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" } ], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0042393 histone binding;GO:0044020 histone H4R3 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0018216 peptidyl-arginine methylation;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q922X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5C5-1", "uniprot_id": [ { "id": "ACTY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5C5", "type": "external" } ], "mass": 42281.0, "length": 376, "protein_name": "Beta-centractin", "gene_name": "Actr1b", "organism": "Mouse", "refseq_name": "beta-centractin isoform b", "refseq_ac": [ { "id": "NP_666219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666219", "type": "external" } ], "gene_names_uniprotkb": "Actr1b", "gene_names_refseq": "2310066K23Rik; Actr1b; Arp1b", "protein_names_uniprotkb": "Beta-centractin; ARP1B; Actin-related protein 1B", "protein_names_refseq": "ARP1 actin-related protein 1 homolog B, centractin beta; actin-related protein 1B; beta-centractin isoform b; beta-centractin", "tax_id": 10090, "disease": "", "pathway": " (mmu:226977); (R-MMU-2132295); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16800626;21750661;26495903;28011936;31219806;33300544;34428180;37828378", "class_list": "", "function": "Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005869 dynactin complex;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R5C5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14824-1", "uniprot_id": [ { "id": "ANXA6_MOUSE", "url": "https://www.uniprot.org/uniprot/P14824", "type": "external" } ], "mass": 75885.0, "length": 673, "protein_name": "Annexin A6", "gene_name": "Anxa6", "organism": "Mouse", "refseq_name": "annexin A6 isoform b", "refseq_ac": [ { "id": "NP_001103681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103681", "type": "external" } ], "gene_names_uniprotkb": "Anxa6; Anx6", "gene_names_refseq": "Anx6; AnxVI; Anxa6; Cabm; Camb", "protein_names_uniprotkb": "Annexin A6; 67 kDa calelectrin; Annexin VI; Annexin-6; CPB-II; Calphobindin-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70", "protein_names_refseq": "67 kDa calelectrin; CPB-II; annexin A6 isoform b; annexin VI, p68; annexin-6; calphobindin-II; chromobindin-20; lipocortin VI; p68; p70", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:11749)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "17947660;18034455;21750661;21913724;23806337;26495903;26740625;2972541;30016717;34428180;36288343;37453647;37507081;37828378;39627609;39927985", "class_list": "", "function": "May associate with CD21. May regulate the release of Ca(2+) from intracellular stores., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSS4", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0034220 monoatomic ion transmembrane transport;GO:0097190 apoptotic signaling pathway;GO:0051560 mitochondrial calcium ion homeostasis;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P14824-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35643-1", "uniprot_id": [ { "id": "AP1B1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35643", "type": "external" } ], "mass": 103935.0, "length": 943, "protein_name": "AP-1 complex subunit beta-1", "gene_name": "Ap1b1", "organism": "Mouse", "refseq_name": "AP-1 complex subunit beta-1 isoform 2", "refseq_ac": [ { "id": "NP_031480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031480", "type": "external" } ], "gene_names_uniprotkb": "Ap1b1; Adtb1", "gene_names_refseq": "Adtb1; Ap1b1; b2b1660Clo", "protein_names_uniprotkb": "AP-1 complex subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; Adaptor-related protein complex 1 subunit beta-1; Beta-1-adaptin; Beta-adaptin 1; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit", "protein_names_refseq": "AP-1 complex subunit beta-1 isoform 2; adaptor protein complex AP-1 subunit beta-1; adaptor-related protein complex AP-1, beta 1 subunit; beta-adaptin 1; beta-prime adaptin; clathrin assembly protein complex 1 beta large chain; golgi adaptor HA1/AP1 adaptin beta subunit", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:11764); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "16800626;18250455;20173027;21750661;26495903;26740625;33300544;33725478;34203471;34428180;37453647;37828378;39627609;9271666", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXG4;Q922E2", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030276 clathrin binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0007507 heart development;GO:0001822 kidney development;GO:0060155 platelet dense granule organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35643-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46660-1", "uniprot_id": [ { "id": "AINX_MOUSE", "url": "https://www.uniprot.org/uniprot/P46660", "type": "external" } ], "mass": 55383.0, "length": 501, "protein_name": "Alpha-internexin", "gene_name": "Ina", "organism": "Mouse", "refseq_name": "alpha-internexin", "refseq_ac": [ { "id": "NP_666212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666212", "type": "external" } ], "gene_names_uniprotkb": "Ina", "gene_names_refseq": "Ina; NF-66; NF66; alpha-Inx", "protein_names_uniprotkb": "Alpha-internexin; 66 kDa neurofilament protein; Alpha-Inx; NF-66; Neurofilament-66", "protein_names_refseq": "66 kDa neurofilament protein; alpha-internexin; neurofilament-66", "tax_id": 10090, "disease": "", "pathway": " (mmu:226180)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16452087;16452088;21183079;22517741;22645316;22723690;22872234;32848054;33300544;34203471;35822049;40021952;40885482;7959004;8734438", "class_list": "", "function": "Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (PubMed:22723690)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q61958;Q8VCW5", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0043209 myelin sheath;GO:0005882 intermediate filament;GO:0098794 postsynapse;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045109 intermediate filament organization;GO:0060052 neurofilament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P46660-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZQ2-1", "uniprot_id": [ { "id": "AFG32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZQ2", "type": "external" } ], "mass": 89519.0, "length": 802, "protein_name": "Mitochondrial inner membrane m-AAA protease component AFG3L2", "gene_name": "Afg3l2", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane m-AAA protease component AFG3L2", "refseq_ac": [ { "id": "NP_081406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081406", "type": "external" } ], "gene_names_uniprotkb": "Afg3l2", "gene_names_refseq": "2310036I02Rik; Afg3l2; Emv66; par", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component AFG3L2; 3.4.24.-; 3.6.-.-; AFG3-like protein 2", "protein_names_refseq": "AFG3 (ATPase family gene 3)-like 2; AFG3-like protein 2; mitochondrial inner membrane m-AAA protease component AFG3L2", "tax_id": 10090, "disease": "spastic ataxia 5 (Disease Ontology:DOID:0050944); spastic ataxia (Disease Ontology:DOID:0050952); spinocerebellar ataxia 28 (Disease Ontology:DOID:0050977); optic atrophy 12 (Disease Ontology:DOID:0080840); neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:69597); (R-MMU-8949664); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "16239145;17101804;17615298;18337413;19656850;20038678;20208537;22563492;22678058;23041622;23806337;24681487;24856930;25428506;27642048;27911893;30389403;30910913;30989755;31219806;31781336;34428180;34678516;36210013;36288343;37507081", "class_list": "", "function": "Astrocyte-specific deletion of Afg3l2 in the mouse leads to late-onset motor impairment and to degeneration of BG, which display aberrant morphology, altered expression of the glutamate transporter EAAT2, and a reactive inflammatory signature. The neurological and glial phenotypes are drastically exacerbated when astrocytes lack both Afg31l and Afg3l2, and therefore, are totally depleted of the m-AAA protease., [RefSeq, PubMed]; Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:16239145, PubMed:18337413, PubMed:22678058, PubMed:27642048, PubMed:30389403). AFG3L2 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (By similarity). The m-AAA protease carries out protein quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (By similarity). The m-AAA protease complex also promotes the processing and maturation of mitochondrial proteins, such as MRPL32/bL32m, PINK1 and SP7 (PubMed:16239145). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:16239145). Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (By similarity). Promotes the proteolytic degradation of GHITM upon hyperpolarization of mitochondria: progressive GHITM degradation leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (By similarity). Also acts as a regulator of mitochondrial glutathione homeostasis by mediating cleavage and degradation of SLC25A39 (By similarity). SLC25A39 cleavage is prevented when SLC25A39 binds iron-sulfur (By similarity). Also acts as a regulator of carnitine biosynthesis by mediating cleavage and degradation of SLC25A45 (By similarity). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:17615298, PubMed:20038678). May act by mediating processing of OMA1 precursor, participating in OMA1 maturation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Our data identify the earliest events in SCA28 pathogenesis and open new perspectives for therapy. By identifying similar mitochondrial phenotypes between SCA28 cells and AFG3L2(+/-) cells, our results support haploinsufficiency as the mechanism for the studied pathogenic variants., [RefSeq, PubMed]; Upregulation of Peroxiredoxin 3 Protects Afg3l2-KO Cortical Neurons In Vitro from Oxidative Stress: A Paradigm for Neuronal Cell Survival under Neurodegenerative Conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.4.24.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.64", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0097228 sperm principal piece;GO:0005745 m-AAA complex;GO:0097225 sperm midpiece", "go_biological_process": "GO:0006508 proteolysis;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0016485 protein processing;GO:0040014 regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8JZQ2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35284-1", "uniprot_id": [ { "id": "BATF_MOUSE", "url": "https://www.uniprot.org/uniprot/O35284", "type": "external" } ], "mass": 14065.0, "length": 125, "protein_name": "Basic leucine zipper transcriptional factor ATF-like", "gene_name": "Batf", "organism": "Mouse", "refseq_name": "basic leucine zipper transcriptional factor ATF-like", "refseq_ac": [ { "id": "NP_058047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058047", "type": "external" } ], "gene_names_uniprotkb": "Batf", "gene_names_refseq": "B-ATF; Batf; SFA-2", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like; B-ATF; B-cell-activating transcription factor", "protein_names_refseq": "B-cell-activating transcription factor; activating transcription factor B; basic leucine zipper transcription factor-like; basic leucine zipper transcriptional factor ATF-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:53314)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11466704;12444555;12594265;12809553;15913695;19578362;20421391;21572431;21873234;22001828;22318729;22385964;22983707;22992523;22992524;23021777", "class_list": "", "function": "AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Fos/Jdp2/Batf locus is associated with SL3-3 mouse leukemia virus B cell lymphoma., [RefSeq, PubMed]; Stat3 mediates cellular growth by modulating AP-1 activity through the induction of BATF, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RT86", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0001819 positive regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35284-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4ZJM9-1", "uniprot_id": [ { "id": "C1QL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4ZJM9", "type": "external" } ], "mass": 24928.0, "length": 238, "protein_name": "Complement C1q-like protein 4", "gene_name": "C1ql4", "organism": "Mouse", "refseq_name": "complement C1q-like protein 4 precursor", "refseq_ac": [ { "id": "NP_001019873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019873", "type": "external" } ], "gene_names_uniprotkb": "C1ql4; C1qtnf11; Ctrp11", "gene_names_refseq": "C1ql4; C1qtnf11; CTRP11", "protein_names_uniprotkb": "Complement C1q-like protein 4; C1q and tumor necrosis factor-related protein 11; C1q/TNF-related protein 11; C1qTNF11; CTRP11", "protein_names_refseq": "C1q and tumor necrosis factor-related protein 11; C1q/TNF-related protein 11; C1qTNF11; complement C1q-like protein 4 precursor; complement C1q-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:239659)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21262840;23449976;30367035;35579659", "class_list": "", "function": "CTRP11 contributes modestly to systemic metabolism and energy balance., [RefSeq, PubMed]; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process., [UniProtKB, PubMed, PubMed]; The secreted complement C1q-like protein 4 repress myoblast fusion by specifically interacting with G protein-coupled receptor BAI3. Publication Status: Online-Only, [RefSeq, PubMed]; These results implicate CTRP11 as a novel secreted regulator of adipogenesis and highlight the potential paracrine cross-talk between adipocytes and cells of the stromal vascular compartment in maintaining adipose tissue homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RV40", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0048147 negative regulation of fibroblast proliferation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0099558 maintenance of synapse structure;GO:0045599 negative regulation of fat cell differentiation;GO:0099550 trans-synaptic signaling, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4ZJM9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQC5-1", "uniprot_id": [ { "id": "BORG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQC5", "type": "external" } ], "mass": 27686.0, "length": 254, "protein_name": "Cdc42 effector protein 3", "gene_name": "Cdc42ep3", "organism": "Mouse", "refseq_name": "cdc42 effector protein 3", "refseq_ac": [ { "id": "NP_080790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080790", "type": "external" } ], "gene_names_uniprotkb": "Cdc42ep3; Borg2; Cep3", "gene_names_refseq": "3200001F04Rik; Borg2; Cdc42ep3; Cep3; UB1", "protein_names_uniprotkb": "Cdc42 effector protein 3; Binder of Rho GTPases 2", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 3; binder of Rho GTPases 2; cdc42 effector protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:260409); (R-MMU-5687128); (R-MMU-9013406)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15345747;19131326;21183079;21750661", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD77;Q8BVR7", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0012505 endomembrane system", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97864-1", "uniprot_id": [ { "id": "CASP7_MOUSE", "url": "https://www.uniprot.org/uniprot/P97864", "type": "external" } ], "mass": 34061.0, "length": 303, "protein_name": "Caspase-7", "gene_name": "Casp7", "organism": "Mouse", "refseq_name": "caspase-7 precursor", "refseq_ac": [ { "id": "NP_031637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031637", "type": "external" } ], "gene_names_uniprotkb": "Casp7; Lice2; Mch3", "gene_names_refseq": "CMH-1; Casp7; ICE-IAP3; Mch3; caspase-7; mCASP-7", "protein_names_uniprotkb": "Caspase-7; 3.4.22.60; Apoptotic protease Mch-3; CASP-7; Cysteine protease LICE2", "protein_names_refseq": "CASP-7; apoptotic protease Mch-3; caspase-7 precursor; cysteine protease LICE2", "tax_id": 10090, "disease": "endometritis (Disease Ontology:DOID:1002); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ureteral obstruction (Disease Ontology:DOID:5199); rheumatoid arthritis (Disease Ontology:DOID:7148); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:12369); (R-MMU-111459); (R-MMU-111463); (R-MMU-111464); (R-MMU-111465); (R-MMU-111469); (R-MMU-264870)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "16469926;17242355;18667412;19168786;21750661;22464733;22807671;25231987;25428506;30878284;31251782;35705808;9038361;9070923;9125129", "class_list": "", "function": "Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:16469926, PubMed:19168786). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:25231987). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (PubMed:18667412, PubMed:35705808). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8 and/or CASP9), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:16469926). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:16469926). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:35705808). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (PubMed:22807671, PubMed:35705808). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (PubMed:35705808). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (By similarity). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (PubMed:25231987). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08669", "ec_number_list": [ { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.60", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97864-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARV4-1", "uniprot_id": [ { "id": "LRP2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARV4", "type": "external" } ], "mass": 519208.0, "length": 4660, "protein_name": "Low-density lipoprotein receptor-related protein 2", "gene_name": "Lrp2", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 2 precursor", "refseq_ac": [ { "id": "NP_001074557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557", "type": "external" } ], "gene_names_uniprotkb": "Lrp2", "gene_names_refseq": "D230004K18Rik; Gp330; Lrp2; Megalin; b2b1625.2Clo", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 2; Glycoprotein 330; LRP-2; Megalin; gp330", "protein_names_refseq": "glycoprotein 330; low-density lipoprotein receptor-related protein 2 precursor", "tax_id": 10090, "disease": "Donnai-Barrow syndrome (Disease Ontology:DOID:0090144); Fanconi syndrome (Disease Ontology:DOID:1062); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); degenerative myopia (Disease Ontology:DOID:11829); myopia (Disease Ontology:DOID:11830); congenital heart disease (Disease Ontology:DOID:1682); nephrosis (Disease Ontology:DOID:2527); autoimmune thyroiditis (Disease Ontology:DOID:7188); end stage renal disease (Disease Ontology:DOID:783); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:14725); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-975634); (R-MMU-9758890)", "pathway_count": 5, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10052453;10766831;10772929;11247302;11964399;12724130;15467006;15623804;16099815;16143106;16380466;17462596;17846082;18174160;19349973;20460439;20637285;21183079;21750661;22340494;22354480;22841573;23825075;24639464;24825475;26439398;26822476;27773703;28659595;31219806;34428180;39950214", "class_list": "", "function": "Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (PubMed:10766831). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (PubMed:22841573). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (PubMed:24825475). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (PubMed:17462596). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (PubMed:10052453). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (PubMed:18174160). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (PubMed:28659595). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (PubMed:15623804). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (PubMed:22340494). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (PubMed:24639464). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (PubMed:20460439). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (PubMed:20637285). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (PubMed:22354480). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (PubMed:26439398). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (PubMed:16143106). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensin 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (PubMed:26822476). Required for normal hearing, possibly through interaction with estrogen in the inner ear (PubMed:17846082)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 39, "reported_o_glycosites": 18, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 14, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 39, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 39, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 49, "disease_count": 11, "glyco_site_count": 61, "binding_glycan_count": 0, "secondary_ac_list": "P70215;Q3TL35;Q9JLB3", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051087 protein-folding chaperone binding;GO:0005509 calcium ion binding;GO:0042562 hormone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006766 vitamin metabolic process;GO:0042359 vitamin D metabolic process;GO:1904888 cranial skeletal system development;GO:0006897 endocytosis;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 14.0, "record_id": "A2ARV4-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YZP9-1", "uniprot_id": [ { "id": "CCDC6_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YZP9", "type": "external" } ], "mass": 52939.0, "length": 469, "protein_name": "Coiled-coil domain-containing protein 6", "gene_name": "Ccdc6", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 6", "refseq_ac": [ { "id": "NP_001104591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104591", "type": "external" } ], "gene_names_uniprotkb": "Ccdc6", "gene_names_refseq": "2810012H18Rik; Ccdc6", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 6", "protein_names_refseq": "coiled-coil domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:76551)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;24129315;25970781;31599954;34428180;35822049;40021952;40885482", "class_list": "", "function": "Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 activity and an increased expression of the CREB-1 regulated genes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "D3YZP9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55088-1", "uniprot_id": [ { "id": "AQP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P55088", "type": "external" } ], "mass": 34436.0, "length": 323, "protein_name": "Aquaporin-4", "gene_name": "Aqp4", "organism": "Mouse", "refseq_name": "aquaporin-4 isoform M23", "refseq_ac": [ { "id": "NP_001295570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295570", "type": "external" } ], "gene_names_uniprotkb": "Aqp4", "gene_names_refseq": "Aqp4; WCH4", "protein_names_uniprotkb": "Aquaporin-4; AQP-4; MIWC; Mercurial-insensitive water channel; WCH4", "protein_names_refseq": "aquaporin-4 isoform M23; mercurial-insensitive water channel", "tax_id": 10090, "disease": "Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); transverse myelitis (Disease Ontology:DOID:0080743); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); uveitis (Disease Ontology:DOID:13141); blindness (Disease Ontology:DOID:1432); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); thymoma (Disease Ontology:DOID:3275); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679); central pontine myelinolysis (Disease Ontology:DOID:636); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); diabetes mellitus (Disease Ontology:DOID:9351); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (mmu:11829); (R-MMU-432040); (R-MMU-432047)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10915655;10960499;11406631;16641094;18286643;20877385;21183079;21750661;22896675;27751903;29055082;30557661;30561329;32848054;37463205;8660998;9143504;9276712", "class_list": "", "function": "Forms a water-specific channel (PubMed:18286643, PubMed:8660998, PubMed:9276712). Plays an important role in brain water homeostasis and in glymphatic solute transport (PubMed:22896675, PubMed:27751903, PubMed:30557661, PubMed:30561329). Required for a normal rate of water exchange across the blood brain interface (PubMed:30557661). Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP (PubMed:22896675, PubMed:27751903, PubMed:30561329). Plays a redundant role in urinary water homeostasis and urinary concentrating ability (PubMed:9276712)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability., [UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that apparent diffusion coefficient values in normal brain are modulated by astrocytic AQP4; suggest imaging changes seen in acute neurologic disorders such as stroke and trauma are in part due to changes in tissue AQP4 levels, [RefSeq, PubMed]; This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 27, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P97818;Q4FJP1;Q61131;Q61132;Q8VHE4;Q8VHE5;Q9EQI3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity;GO:0015267 channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0071333 cellular response to glucose stimulus;GO:0032691 negative regulation of interleukin-1 beta production;GO:0032715 negative regulation of interleukin-6 production;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P55088-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6F3F9-1", "uniprot_id": [ { "id": "AGRG6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6F3F9", "type": "external" } ], "mass": 129721.0, "length": 1165, "protein_name": "Adhesion G protein-coupled receptor G6", "gene_name": "Adgrg6", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor G6 precursor", "refseq_ac": [ { "id": "NP_001002268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002268", "type": "external" } ], "gene_names_uniprotkb": "Adgrg6; Dreg; Gm222; Gpr126", "gene_names_refseq": "1190004A11Rik; Adgrg6; DREG; Gm222; Gpr126", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G6; ADGRG6 C-terminal fragment; ADGRG6 N-terminal fragment; ADGRG6-CTF; ADGRG6-NTF; Developmentally regulated G protein-coupled receptor; G protein-coupled receptor 126", "protein_names_refseq": "G protein coupled receptor Gpr126; adhesion G-protein coupled receptor G6 precursor; developmentally regulated G-protein-coupled receptor; probable G-protein coupled receptor 126", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (mmu:215798); (R-MMU-9619665)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;15189448;19656770;21124978;21183079;21613327;21750661;24082093;24227709;25217645;25428506;25695270;25954032;26495903;27501152;27927955;28011936;30059200;32219165;34767447;38786096;39087467", "class_list": "", "function": "Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys. Publication Status: Online-Only, [RefSeq, PubMed]; Adhesion G protein-coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP) (By similarity). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (PubMed:21613327, PubMed:24082093, PubMed:24227709, PubMed:25217645, PubMed:25695270, PubMed:25954032, PubMed:27501152, PubMed:34767447). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity). Also able to couple to G(q) G proteins (By similarity). Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:21613327, PubMed:24227709, PubMed:27927955). Also acts as a regulator of body length and bone mass (PubMed:32219165). Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (PubMed:39087467)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1., [UniProtKB, UniProtKB, UniProtKB]; Analysis shows that Gpr126 is required for Schwann cell myelination in mammals, and defines new roles for Gpr126 in axonal sorting, formation of mature non-myelinating Schwann cells and organization of the perineurium., [RefSeq, PubMed]; Data show that GPR126 is required for embryonic viability and cardiovascular development. Publication Status: Online-Only, [RefSeq, PubMed]; GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 19, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "Q811E4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0060856 establishment of blood-brain barrier;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q6F3F9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30561-1", "uniprot_id": [ { "id": "AHR_MOUSE", "url": "https://www.uniprot.org/uniprot/P30561", "type": "external" } ], "mass": 95017.0, "length": 848, "protein_name": "Aryl hydrocarbon receptor", "gene_name": "Ahr", "organism": "Mouse", "refseq_name": "aryl hydrocarbon receptor isoform 1", "refseq_ac": [ { "id": "NP_038492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038492", "type": "external" } ], "gene_names_uniprotkb": "Ahr", "gene_names_refseq": "Ahh; Ahre; Ahr; Ah; In; bHLHe76", "protein_names_uniprotkb": "Aryl hydrocarbon receptor; Ah receptor; AhR", "protein_names_refseq": "ah receptor; aryl hydrocarbon receptor isoform 1; dioxin receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); traumatic brain injury (Disease Ontology:DOID:0081292); retinitis pigmentosa 85 (Disease Ontology:DOID:0112142); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcoholic hepatitis (Disease Ontology:DOID:12351); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary hypertension (Disease Ontology:DOID:6432); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": " (mmu:11622); (R-MMU-211945); (R-MMU-211976); (R-MMU-211981); (R-MMU-8937144)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10639156;10973493;11875369;11956195;12213388;12215427;1314586;1325649;15581363;1846217;20106950;21750661;24001774;28396409;29726989;33436590;34428180;7961644;7969080;8148872;8408082;8806768;8806883;9427285", "class_list": "", "function": "Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:10639156, PubMed:10973493, PubMed:1314586, PubMed:33436590, PubMed:7961644, PubMed:7969080, PubMed:8806883, PubMed:9427285). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (By similarity). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:20106950, PubMed:28396409). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:10639156, PubMed:10973493, PubMed:1314586, PubMed:7961644, PubMed:7969080, PubMed:8806883, PubMed:9427285). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (By similarity). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (By similarity). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (By similarity). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (By similarity). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (By similarity). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:20106950).The heterodimer ARNT:AHR binds to the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZX6;Q8R4S3;Q99P79;Q9QVY1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0015643 toxic substance binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0060242 contact inhibition;GO:0060420 regulation of heart growth;GO:0060993 kidney morphogenesis;GO:0002260 lymphocyte homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P30561-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PB70-1", "uniprot_id": [ { "id": "ANO8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PB70", "type": "external" } ], "mass": 119101.0, "length": 1060, "protein_name": "Anoctamin-8", "gene_name": "Ano8", "organism": "Mouse", "refseq_name": "anoctamin-8", "refseq_ac": [ { "id": "NP_001158151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158151", "type": "external" } ], "gene_names_uniprotkb": "Ano8; Kiaa1623; Tmem16h", "gene_names_refseq": "Ano8; Tmem16h", "protein_names_uniprotkb": "Anoctamin-8; Transmembrane protein 16H", "protein_names_refseq": "anoctamin-8; transmembrane protein 16H", "tax_id": 10090, "disease": "", "pathway": " (mmu:382014); (R-MMU-2672351); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "15647853;18729231;19059364;20056604;21183079;21750661;22302790;24129315;31219806", "class_list": "", "function": "Data show the expression of Tmem16h during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems., [RefSeq, PubMed]; Does not exhibit calcium-activated chloride channel (CaCC) activity., [UniProtKB, UniProtKB]; During mouse cephalic development: detected in subventricular zone and differentiating fields, In organs developing through epithelial-mesenchymal interactions, such as the palate, tooth and tongue, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05CB5;Q69ZE4", "ec_number_list": [], "go_molecular_function": "GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6PB70-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AH22-1", "uniprot_id": [ { "id": "AMRA1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AH22", "type": "external" } ], "mass": 142879.0, "length": 1300, "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1", "gene_name": "Ambra1", "organism": "Mouse", "refseq_name": "activating molecule in BECN1-regulated autophagy protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001074223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223", "type": "external" } ], "gene_names_uniprotkb": "Ambra1; Kiaa1736", "gene_names_refseq": "2310079H06Rik; A130023A14; Ambra1; D030051N19Rik; mKIAA1736", "protein_names_uniprotkb": "Activating molecule in BECN1-regulated autophagy protein 1", "protein_names_refseq": "activating molecule in BECN1-regulated autophagy protein 1 isoform 2; activating molecule in BECN1-regulated autophagy protein 1; activating molecule in Beclin1-regulated autophagy", "tax_id": 10090, "disease": "multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (mmu:228361); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "17589504;17603510;21753002;23974797;24089209;24129315;24980959;25215947;25438055;28362576;28789945;30084848;30513302;31219806;32616651;32782141;32848054;33854232;33854235;33854239;34428180;35822049;36852467;36868570;38424148;40021952;40885482", "class_list": "", "function": "AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner., [RefSeq, PubMed]; Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death, [RefSeq, PubMed]; Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma., [RefSeq, PubMed]; Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:17589504, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23974797, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:17589504). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (By similarity). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (PubMed:23974797). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (By similarity). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (By similarity). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (By similarity). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:28789945, PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (PubMed:28362576). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (PubMed:32616651)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AH21;A2AH24;Q3TF60;Q3U239;Q3UF70;Q6ZPJ1;Q8BJJ8;Q8BYW8", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0051020 GTPase binding;GO:0019903 protein phosphatase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "A2AH22-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AHL1-1", "uniprot_id": [ { "id": "ANO3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AHL1", "type": "external" } ], "mass": 114568.0, "length": 981, "protein_name": "Anoctamin-3", "gene_name": "Ano3", "organism": "Mouse", "refseq_name": "anoctamin-3 isoform 1", "refseq_ac": [ { "id": "NP_001121575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575", "type": "external" } ], "gene_names_uniprotkb": "Ano3; Tmem16c", "gene_names_refseq": "Ano3; B230324K02Rik; Tmem16c", "protein_names_uniprotkb": "Anoctamin-3; Transmembrane protein 16C", "protein_names_refseq": "anoctamin-3 isoform 1", "tax_id": 10090, "disease": "dystonia 24 (Disease Ontology:DOID:0090052)", "pathway": " (mmu:228432); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18729231;19059364;20056604;21750661;22302790;23532839;23872594;33972431", "class_list": "", "function": "Data report the expression of Tmem16c during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems., [RefSeq, PubMed]; During mouse cephalic development: detectable in the subventricular zone and differentiating fields, patent in the submandibular autonomic ganglia, detected in osteoblasts and chondrocytes, in palate, tooth and tongue, [RefSeq, PubMed]; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594)., [UniProtKB, PubMed, PubMed]; TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AHL0", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0061590 calcium activated phosphatidylcholine scrambling;GO:0061591 calcium activated galactosylceramide scrambling;GO:0016048 detection of temperature stimulus;GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2AHL1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARS0-1", "uniprot_id": [ { "id": "ANR63_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARS0", "type": "external" } ], "mass": 41068.0, "length": 390, "protein_name": "Ankyrin repeat domain-containing protein 63", "gene_name": "Ankrd63", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 63", "refseq_ac": [ { "id": "NP_001075440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075440", "type": "external" } ], "gene_names_uniprotkb": "Ankrd63; Gm1337", "gene_names_refseq": "Ankrd63; Gm1337", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 63", "protein_names_refseq": "ankyrin repeat domain-containing protein 63; novel ankyrin repeat domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:383787)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;22645316", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2ARS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BH40-1", "uniprot_id": [ { "id": "ARI1A_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BH40", "type": "external" } ], "mass": 242092.0, "length": 2283, "protein_name": "AT-rich interactive domain-containing protein 1A", "gene_name": "Arid1a", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 1A isoform 1", "refseq_ac": [ { "id": "NP_001074288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288", "type": "external" } ], "gene_names_uniprotkb": "Arid1a; Baf250a; Baf250; Osa1; Smarcf1", "gene_names_refseq": "1110030E03Rik; Arid1a; BAF250a; BAF250; Osa1; Smarcf1", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; BAF250A; BAF250; BRG1-associated factor 250a; BRG1-associated factor 250; Osa homolog 1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1", "protein_names_refseq": "ARID domain-containing protein 1A; AT rich interactive domain 1A (SWI-like); AT rich interactive domain 1A (Swi1 like); AT-rich interactive domain-containing protein 1A isoform 1; AT-rich interactive domain-containing protein 1A; BRG1-associated factor 250a; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; osa homolog 1", "tax_id": 10090, "disease": "ovarian clear cell carcinoma (Disease Ontology:DOID:0050934); Coffin-Siris syndrome 1 (Disease Ontology:DOID:0070042); Coffin-Siris syndrome 2 (Disease Ontology:DOID:0070044); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); colon cancer (Disease Ontology:DOID:219); endometrial adenocarcinoma (Disease Ontology:DOID:2870); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophagus adenocarcinoma (Disease Ontology:DOID:4914); Klatskin's tumor (Disease Ontology:DOID:4927); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:93760); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9933946); (R-MMU-9934037)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11318604;17242355;17640523;19144319;21183079;21750661;22952240;24129315;26601204;29272704;30899004;31219806;32782141;32848054;34203471;34428180;34678516;36852467;40021952;40885482", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 20, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q640Q1;Q925Q1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016922 nuclear receptor binding;GO:0140658 ATP-dependent chromatin remodeler activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0071565 nBAF complex;GO:0000785 chromatin", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "A2BH40-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV76-1", "uniprot_id": [ { "id": "AP4B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV76", "type": "external" } ], "mass": 82976.0, "length": 738, "protein_name": "AP-4 complex subunit beta-1", "gene_name": "Ap4b1", "organism": "Mouse", "refseq_name": "AP-4 complex subunit beta-1 isoform a", "refseq_ac": [ { "id": "NP_001157024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157024", "type": "external" } ], "gene_names_uniprotkb": "Ap4b1; Gm43064", "gene_names_refseq": "1810038H16Rik; Ap4b1; Ap4b4", "protein_names_uniprotkb": "AP-4 complex subunit beta-1; AP-4 adaptor complex subunit beta; Adaptor-related protein complex 4 subunit beta-1; Beta subunit of AP-4; Beta4-adaptin", "protein_names_refseq": "AP-4 adapter complex subunit beta; AP-4 adaptor complex subunit beta; AP-4 beta-4; AP-4 complex subunit beta-1 isoform a; AP-4 complex subunit beta-1; adapter-related protein complex 4 subunit beta-1; adaptor-related protein complex 4 subunit beta-1; beta subunit of AP-4; beta4-adaptin", "tax_id": 10090, "disease": "hereditary spastic paraplegia 47 (Disease Ontology:DOID:0110799)", "pathway": " (mmu:67489); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10436028;18341993;21750661;31219806;34428180", "class_list": "", "function": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V3P2", "ec_number_list": [], "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030131 clathrin adaptor complex;GO:0030124 AP-4 adaptor complex;GO:0098541 cytoplasmic side of trans-Golgi network transport vesicle membrane", "go_biological_process": "GO:0061938 protein localization to somatodendritic compartment;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WV76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U5C8-1", "uniprot_id": [ { "id": "ARHGG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U5C8", "type": "external" } ], "mass": 80381.0, "length": 713, "protein_name": "Rho guanine nucleotide exchange factor 16", "gene_name": "Arhgef16", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 16", "refseq_ac": [ { "id": "NP_001106215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106215", "type": "external" } ], "gene_names_uniprotkb": "Arhgef16", "gene_names_refseq": "Arhgef16", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 16; Ephexin-4", "protein_names_refseq": "Neuroblastoma; Rho guanine nucleotide exchange factor (GEF) 16; ephexin-4; rho guanine nucleotide exchange factor 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:230972); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148); (R-MMU-9013408)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "15848799;17242355;21183079;21750661;31219806", "class_list": "", "function": "Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASH6;Q501M8;Q8VCE8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030165 PDZ domain binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0032489 regulation of Cdc42 protein signal transduction;GO:0060326 cell chemotaxis;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0090630 activation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U5C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AXD8-1", "uniprot_id": [ { "id": "AKIR2_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AXD8", "type": "external" } ], "mass": 22113.0, "length": 201, "protein_name": "Akirin-2", "gene_name": "Akirin2", "organism": "Mouse", "refseq_name": "akirin-2", "refseq_ac": [ { "id": "NP_001007590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007590", "type": "external" } ], "gene_names_uniprotkb": "Akirin2", "gene_names_refseq": "2700059D21Rik; Akirin-2; Akirin2", "protein_names_uniprotkb": "Akirin-2", "protein_names_refseq": "akirin-2", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340)", "pathway": " (mmu:433693)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;18066067;21183079;25107474;26041538;27871306;28605346;30116001;30801883", "class_list": "", "function": "Data demonstrate a previously-unsuspected role for Akirin2 in early cortical development and, given its known nuclear roles, suggest that it may act to regulate gene expression patterns critical for early progenitor cell behavior and cortical neuron production. Publication Status: Online-Only, [RefSeq, PubMed]; Essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression Publication Status: Online-Only, [RefSeq, PubMed]; Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:25107474, PubMed:26041538, PubMed:27871306, PubMed:30116001, PubMed:30801883). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (PubMed:18066067, PubMed:25107474). Also involved in adaptive immunity by promoting B-cell activation (PubMed:26041538). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (PubMed:27871306). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:30801883). Also plays a role in facilitating interdigital tissue regression during limb development (PubMed:30116001)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The IkappaB-zeta-Akirin2-BAF60 complex physically links the NF-kappaB and SWI/SNF complexes in innate immune cell activation., [RefSeq, PubMed]; The nuclear protein akirin2 has an essential function in B cell activation and humoral immune responses., [RefSeq, PubMed]; This review discusses current understanding of the molecular mechanisms that have instrumental roles in governing the inflammatory response with special emphasis on Akirin2 in B cells Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q641L8;Q9DAH4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B1AXD8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG79-1", "uniprot_id": [ { "id": "ASPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG79", "type": "external" } ], "mass": 125301.0, "length": 1128, "protein_name": "Apoptosis-stimulating of p53 protein 2", "gene_name": "Tp53bp2; Trp53bp2", "organism": "Mouse", "refseq_name": "apoptosis-stimulating of p53 protein 2", "refseq_ac": [ { "id": "NP_775554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775554", "type": "external" } ], "gene_names_uniprotkb": "Tp53bp2; Trp53bp2; Aspp2; Trp53bp2", "gene_names_refseq": "53BP2; ASPP2; PPP1R13A; Tp53bp2; Trp53bp2", "protein_names_uniprotkb": "Apoptosis-stimulating of p53 protein 2; 53BP2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2", "protein_names_refseq": "apoptosis-stimulating of p53 protein 2; p53-binding protein 2; p53BP2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2", "tax_id": 10090, "disease": "chromosome 1q41-q42 deletion syndrome (Disease Ontology:DOID:0060412)", "pathway": " (mmu:209456); (R-MMU-6804759)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;16702401;17242355;17965023;19131326;19251665;21183079;21750661;22517741;22645316;30016717;30059200;31219806;32782141;32848054;34428180;35504951;36466835;36852467;38840923;40021952;40885482", "class_list": "", "function": "53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates., [RefSeq, PubMed]; ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression., [RefSeq, PubMed]; ASPP2(+/-) mice appeared developmentally normal, they displayed an increased incidence of a variety of spontaneous tumors as they aged, [RefSeq, PubMed]; Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice. Publication Status: Online-Only, [RefSeq, PubMed]; Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma., [RefSeq, PubMed]; Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (By similarity). Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYM7;Q8K2L5", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0002039 p53 binding;GO:0042803 protein homodimerization activity;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005829 cytosol;GO:0030054 cell junction", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:1900119 positive regulation of execution phase of apoptosis", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8CG79-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55302-1", "uniprot_id": [ { "id": "AMRP_MOUSE", "url": "https://www.uniprot.org/uniprot/P55302", "type": "external" } ], "mass": 42215.0, "length": 360, "protein_name": "Alpha-2-macroglobulin receptor-associated protein", "gene_name": "Lrpap1", "organism": "Mouse", "refseq_name": "alpha-2-macroglobulin receptor-associated protein precursor", "refseq_ac": [ { "id": "NP_038615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038615", "type": "external" } ], "gene_names_uniprotkb": "Lrpap1", "gene_names_refseq": "HBP44; Lrpap1; RAP", "protein_names_uniprotkb": "Alpha-2-macroglobulin receptor-associated protein; Alpha-2-MRAP; HBP-44; Heparin-binding protein 44; Low density lipoprotein receptor-related protein-associated protein 1; RAP", "protein_names_refseq": "alpha-2-MRAP; alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-MRAP); alpha-2-macroglobulin receptor-associated protein precursor; heparin-binding protein 44", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); membranous glomerulonephritis (Disease Ontology:DOID:10976); myopia (Disease Ontology:DOID:11830); dementia (Disease Ontology:DOID:1307); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16976)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;2229028;30059200;30899004;31219806;31770536;34428180;37743411;37828378;38035103;40885482;8282724", "class_list": "", "function": "Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model., [RefSeq, PubMed]; LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway., [UniProtKB, UniProtKB]; Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0048019 receptor antagonist activity;GO:0035473 lipase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0002091 negative regulation of receptor internalization;GO:0010916 negative regulation of very-low-density lipoprotein particle clearance;GO:0048259 regulation of receptor-mediated endocytosis;GO:1900222 negative regulation of amyloid-beta clearance", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P55302-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UP5-1", "uniprot_id": [ { "id": "AN13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UP5", "type": "external" } ], "mass": 67177.0, "length": 588, "protein_name": "Ankyrin repeat domain-containing protein 13A", "gene_name": "Ankrd13a", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 13A isoform 1", "refseq_ac": [ { "id": "NP_080994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080994", "type": "external" } ], "gene_names_uniprotkb": "Ankrd13a; Ankrd13", "gene_names_refseq": "1100001D10Rik; ANKRD13; Ankrd13a", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 13A", "protein_names_refseq": "ankyrin repeat domain-containing protein 13A isoform 1; ankyrin repeat domain-containing protein 13A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68420)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17525332;18250455;21750661;30084848;30779550;34428180", "class_list": "", "function": "Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2VPQ7;Q6P7F2", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0002091 negative regulation of receptor internalization;GO:0048259 regulation of receptor-mediated endocytosis;GO:1905667 negative regulation of protein localization to endosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80UP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62331-1", "uniprot_id": [ { "id": "ARF6_MOUSE", "url": "https://www.uniprot.org/uniprot/P62331", "type": "external" } ], "mass": 20082.0, "length": 175, "protein_name": "ADP-ribosylation factor 6", "gene_name": "Arf6", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor 6", "refseq_ac": [ { "id": "NP_031507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031507", "type": "external" } ], "gene_names_uniprotkb": "Arf6", "gene_names_refseq": "Arf6", "protein_names_uniprotkb": "ADP-ribosylation factor 6; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 6", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:11845); (R-MMU-8854214); (R-MMU-8856828); (R-MMU-8875656)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "11950392;12509462;12810696;14585928;16325184;20080746;22522702;22841714;23572513;26495903;27723745;29420262;31219806;34428180;38242343;38334661;38545783;39627609;8947846", "class_list": "", "function": "ARF6 is activated by H-Ras, which along with RalA, leads to phospholipase D activation, [RefSeq, PubMed]; ARF6 is activated in macrophages when phagocytosis is initiated via receptors for the Fc portion of immunoglobulins (FcRs). A dominant-negative mutant of ARF6 dramatically affected FcR-mediated phagocytosis., [RefSeq, PubMed]; ARF6 is required to sustain adequate levels of PI(4,5)P2 during periods of increased PI(4,5)P2 metabolism such as regulated secretion, [RefSeq, PubMed]; ARF6, a component of intercellular bridges, is essential for spermatogenesis in mice., [RefSeq, PubMed]; Endothelial-Specific Reduction in Arf6 Impairs Insulin-Stimulated Vasodilation and Skeletal Muscle Blood Flow Resulting in Systemic Insulin Resistance in Mice., [RefSeq, PubMed]; Evidence for Involvement of ADP-Ribosylation Factor 6 in Intracellular Trafficking and Release of Murine Leukemia Virus Gag. Publication Status: Online-Only, [RefSeq, PubMed]; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11950392). Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (PubMed:20080746, PubMed:29420262). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P26438", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031996 thioesterase binding;GO:0035591 signaling adaptor activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903438 positive regulation of mitotic cytokinetic process;GO:0001889 liver development;GO:0006886 intracellular protein transport;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P62331-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02013-1", "uniprot_id": [ { "id": "AQP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02013", "type": "external" } ], "mass": 28793.0, "length": 269, "protein_name": "Aquaporin-1", "gene_name": "Aqp1", "organism": "Mouse", "refseq_name": "aquaporin-1", "refseq_ac": [ { "id": "NP_031498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031498", "type": "external" } ], "gene_names_uniprotkb": "Aqp1", "gene_names_refseq": "Aqp1; CHIP28", "protein_names_uniprotkb": "Aquaporin-1; AQP-1; Aquaporin-CHIP; DER2; Delayed early response protein 2", "protein_names_refseq": "AQP-1; DER2; aquaporin-1; aquaporin-CHIP; delayed early response protein 2; growth factor-induced delayed early response protein; water channel protein for red blood cells and kidney proximal tubule", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); uveitis (Disease Ontology:DOID:13141); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); brain edema (Disease Ontology:DOID:4724); central pontine myelinolysis (Disease Ontology:DOID:636); diabetes mellitus (Disease Ontology:DOID:9351); intracranial hypertension (Disease Ontology:DOID:9428)", "pathway": " (mmu:11826); (R-MMU-1237044); (R-MMU-1247673); (R-MMU-432040); (R-MMU-432047)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10839360;12133842;1508193;17242355;21183079;22645316;25428506;26495903;30084848;31599954;31605441;34428180", "class_list": "", "function": "Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:12133842). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q542P1;Q91VY8", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding;GO:0005267 potassium channel activity;GO:0005372 water transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane", "go_biological_process": "GO:0019725 cellular homeostasis;GO:0030335 positive regulation of cell migration;GO:0032940 secretion by cell;GO:0043066 negative regulation of apoptotic process;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q02013-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWH6-1", "uniprot_id": [ { "id": "ARHGF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FWH6", "type": "external" } ], "mass": 92946.0, "length": 849, "protein_name": "Rho guanine nucleotide exchange factor 15", "gene_name": "Arhgef15", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 15 isoform 1", "refseq_ac": [ { "id": "NP_808234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808234", "type": "external" } ], "gene_names_uniprotkb": "Arhgef15; Kiaa0915", "gene_names_refseq": "Arhgef15; D130071N09; D530030K12Rik; E5", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 15; E5; Ephexin-5", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 15; ephexin-5; rho guanine nucleotide exchange factor 15 isoform 1", "tax_id": 10090, "disease": "brain small vessel disease 5 with osteoporosis (Disease Ontology:DOID:0061235)", "pathway": " (mmu:442801); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "15848799;17242355;21029865;21183079;34428180;36603298;36929019", "class_list": "", "function": "ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that activates RhoA, playing a role in the regulation of actin cytoskeleton organization (PubMed:36929019). Is involved in the regulation of vascular smooth muscle contractility (By similarity). In addition to this process, it negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2 (PubMed:21029865). Does not activate RAC1 or CDC42., [UniProtKB, PubMed, UniProtKB, PubMed]; Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture., [RefSeq, PubMed]; Study identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor triggers Ephexin5 phosphorylation, ubiquitination, and degradation.[Ephexin5], [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q14B44;Q69ZV7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0098794 postsynapse", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0035025 positive regulation of Rho protein signal transduction;GO:0061299 retina vasculature morphogenesis in camera-type eye;GO:2000297 negative regulation of synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5FWH6-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61176-1", "uniprot_id": [ { "id": "ARGI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61176", "type": "external" } ], "mass": 34808.0, "length": 323, "protein_name": "Arginase-1", "gene_name": "Arg1", "organism": "Mouse", "refseq_name": "arginase-1", "refseq_ac": [ { "id": "NP_031508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031508", "type": "external" } ], "gene_names_uniprotkb": "Arg1", "gene_names_refseq": "AI; Arg-1; Arg1; PGIF", "protein_names_uniprotkb": "Arginase-1; 3.5.3.1; Liver-type arginase; Type I arginase", "protein_names_refseq": "arginase 1, liver; arginase I; arginase-1; liver-type arginase; type I arginase", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); silicosis (Disease Ontology:DOID:10325); hypertension (Disease Ontology:DOID:10763); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); liver disease (Disease Ontology:DOID:409); ureteral obstruction (Disease Ontology:DOID:5199); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperargininemia (Disease Ontology:DOID:9278)", "pathway": " (mmu:11846); (R-MMU-6798695); (R-MMU-70635)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "12193690;15313928;17242355;19360123;19414774;20483789;21183079;23248265;23552798;23637937;23806337;27043409;32069316;34428180;37453647;7537672", "class_list": "", "function": "Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (By similarity). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (PubMed:27043409). Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation; the regulatory outcome seems to be organ specific (PubMed:19360123, PubMed:20483789, PubMed:23552798, PubMed:23637937, PubMed:7537672). In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity (PubMed:19414774, PubMed:23248265)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB74;Q3UEL0;Q4FK78;Q80VI4", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.5.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.-", "type": "external" }, { "id": "3.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17", "type": "external" }, { "id": "3.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0004053 arginase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0045087 innate immune response;GO:0042130 negative regulation of T cell proliferation;GO:0001938 positive regulation of endothelial cell proliferation;GO:0002250 adaptive immune response;GO:0000050 urea cycle", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q61176-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VK6-3", "uniprot_id": [ { "id": "ARH38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VK6", "type": "external" } ], "mass": 87679.0, "length": 770, "protein_name": "Rho guanine nucleotide exchange factor 38", "gene_name": "Arhgef38", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 38 isoform 2", "refseq_ac": [ { "id": "NP_084229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084229", "type": "external" } ], "gene_names_uniprotkb": "Arhgef38", "gene_names_refseq": "9130221D24Rik; Arhgef38; D630013G24Rik", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 38", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 38; putative Rho guanine nucleotide exchange factor FLJ20184 homolog; rho guanine nucleotide exchange factor 38 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77669); (R-MMU-193648); (R-MMU-416482)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "May act as a guanine-nucleotide releasing factor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E2QRQ2;Q9D274", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80VK6-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5G7-1", "uniprot_id": [ { "id": "ARAP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5G7", "type": "external" } ], "mass": 169741.0, "length": 1538, "protein_name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3", "gene_name": "Arap3", "organism": "Mouse", "refseq_name": "arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001192265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192265", "type": "external" } ], "gene_names_uniprotkb": "Arap3; Centd3; Drag1; Kiaa4097", "gene_names_refseq": "Arap3; Centd3; Drag1; E030006K04Rik; cnt-d3", "protein_names_uniprotkb": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; Centaurin-delta-3; Cnt-d3; Dual specificity Rho- and Arf-GTPase-activating protein 1", "protein_names_refseq": "ARF-GAP, RHO-GAP, ankyrin repeat and pleckstrin homology domains-containing protein 3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; centaurin, delta 3; dual-specificity Rho- and Arf-GTPase activating protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106952); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "15546919;17947660;18765673;20978237;21183079;21750661;38734878", "class_list": "", "function": "ARAP3 has a role in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading, [RefSeq, PubMed]; ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils., [RefSeq, PubMed]; PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA., [UniProtKB, PubMed]; The Nck adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor, [RefSeq, PubMed]; This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QMK7;Q5DTN4;Q6NVF1;Q8R5G6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0001726 ruffle", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0030336 negative regulation of cell migration;GO:0008360 regulation of cell shape;GO:0035024 negative regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R5G7-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0J4-1", "uniprot_id": [ { "id": "ARL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0J4", "type": "external" } ], "mass": 20864.0, "length": 184, "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "Arl2", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 2", "refseq_ac": [ { "id": "NP_062696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062696", "type": "external" } ], "gene_names_uniprotkb": "Arl2", "gene_names_refseq": "2610009M23Rik; Arl2", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 2", "protein_names_refseq": "ADP-ribosylation factor-like protein 2; ADP-ribosylation-like 2; arf-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56327); (R-MMU-83936); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11809823;11980706;15979089;21183079;34389797;34428180;36300495;36611941;39137170", "class_list": "", "function": "Arf-like Protein 2 (ARL2) Controls Microtubule Neogenesis during Early Postnatal Photoreceptor Development. Publication Status: Online-Only, [RefSeq, PubMed]; Arf-like protein 2 interaction with PDEdelta is dependent on GTP, and the binding of PDEdelta substantially stabilizes GTP binding; data suggests that Arl2/3 are specific regulators of PDEdelta, [RefSeq, PubMed]; Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to regulate cortical development via microtubule organization. Publication Status: Online-Only, [RefSeq, PubMed]; Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling., [RefSeq, PubMed]; LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhibition., [RefSeq, PubMed]; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUM1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0015870 acetylcholine transport;GO:0006110 regulation of glycolytic process;GO:0010811 positive regulation of cell-substrate adhesion;GO:0031113 regulation of microtubule polymerization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D0J4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTY4-1", "uniprot_id": [ { "id": "AQP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTY4", "type": "external" } ], "mass": 28274.0, "length": 265, "protein_name": "Aquaporin-5", "gene_name": "Aqp5", "organism": "Mouse", "refseq_name": "aquaporin-5", "refseq_ac": [ { "id": "NP_033831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033831", "type": "external" } ], "gene_names_uniprotkb": "Aqp5", "gene_names_refseq": "Aqp5", "protein_names_uniprotkb": "Aquaporin-5; AQP-5", "protein_names_refseq": "AQP-5; aquaporin-5", "tax_id": 10090, "disease": "Bothnian type palmoplantar keratoderma (Disease Ontology:DOID:0111707); dry eye syndrome (Disease Ontology:DOID:10140); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:11830); (R-MMU-432047)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10337625;10400615;10619865;12042359;16571723;18027168;21633078;21750661;23473857;29751100;34796038", "class_list": "", "function": "Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (By similarity). Plays an important role in fluid secretion in salivary glands (PubMed:10400615, PubMed:16571723, PubMed:18027168). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (PubMed:10619865, PubMed:12042359, PubMed:18027168)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q545H1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity;GO:0015267 channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005902 microvillus", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0046541 saliva secretion;GO:0051289 protein homotetramerization;GO:0030157 pancreatic juice secretion;GO:0042476 odontogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WTY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUA6-1", "uniprot_id": [ { "id": "AKT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUA6", "type": "external" } ], "mass": 55714.0, "length": 479, "protein_name": "RAC-gamma serine/threonine-protein kinase", "gene_name": "Akt3", "organism": "Mouse", "refseq_name": "RAC-gamma serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_035915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035915", "type": "external" } ], "gene_names_uniprotkb": "Akt3", "gene_names_refseq": "Akt3; D930002M15Rik; Nmf350", "protein_names_uniprotkb": "RAC-gamma serine/threonine-protein kinase; 2.7.11.1; PKB gamma; Protein kinase Akt-3; Protein kinase B gamma; RAC-PK-gamma", "protein_names_refseq": "PKB gamma; RAC-PK-gamma; RAC-gamma serine/threonine-protein kinase; protein kinase Akt-3; protein kinase B gamma; thymoma viral proto-oncogene 3", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); prostate adenocarcinoma (Disease Ontology:DOID:2526); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:23797); (R-MMU-1257604); (R-MMU-1358803); (R-MMU-165159); (R-MMU-165181); (R-MMU-198323); (R-MMU-198693); (R-MMU-199418); (R-MMU-211163); (R-MMU-389357); (R-MMU-389513); (R-MMU-392451); (R-MMU-5218920); (R-MMU-5628897); (R-MMU-6804757); (R-MMU-6804758); (R-MMU-6804759); (R-MMU-69202); (R-MMU-69656); (R-MMU-8876198); (R-MMU-8948751); (R-MMU-9607240); (R-MMU-9614399); (R-MMU-9634638); (R-MMU-9755511); (R-MMU-9856649)", "pathway_count": 26, "publication_count": 15, "publication_id_list": "10092583;10491192;11387345;15713641;18160256;18524868;21159799;21620960;21954288;24156551;32291381;34428180;36852467;37828378;39197298", "class_list": "", "function": "AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis., [UniProtKB, PubMed, PubMed, PubMed]; Integrated analyses of 5 mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer's disease., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005080 protein kinase C binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WUA6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV31-1", "uniprot_id": [ { "id": "ARC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV31", "type": "external" } ], "mass": 45321.0, "length": 396, "protein_name": "Activity-regulated cytoskeleton-associated protein", "gene_name": "Arc", "organism": "Mouse", "refseq_name": "activity-regulated cytoskeleton-associated protein", "refseq_ac": [ { "id": "NP_001263613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263613", "type": "external" } ], "gene_names_uniprotkb": "Arc", "gene_names_refseq": "Arc3.1; Arc; arg3.1; mArc", "protein_names_uniprotkb": "Activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein; Arg3.1; mArc", "protein_names_refseq": "ARC/ARG3.1; activity-regulated cytoskeleton-associated protein; activity-regulated gene 3.1 protein homolog", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:11838)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10727859;11466419;12493697;17088210;17088213;19116276;20211139;20228806;22036569;22645316;23791196;24094104;25428506;27038743;27524619;28783680;29264923;31151856", "class_list": "", "function": "Highly expressed both at the RNA and protein levels in postmeiotic germ cells in the testis of adult mice, [RefSeq, PubMed]; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (By similarity). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (By similarity). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (By similarity). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory (PubMed:24094104, PubMed:29264923, PubMed:31151856). Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis (PubMed:17088213, PubMed:20211139, PubMed:20228806). Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses (PubMed:23791196). Accumulates at weaker synapses, probably to prevent their undesired enhancement (By similarity). This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material (By similarity). Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (PubMed:17088210, PubMed:20228806). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (PubMed:22036569). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (PubMed:28783680)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study reports that the immediate early gene Arc is required for activity-dependent generation of Abeta. Arc is a postsynaptic protein that recruits endophilin2/3 and dynamin to early/recycling endosomes that traffic, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ES15", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003779 actin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0110077 vesicle-mediated intercellular transport;GO:0006897 endocytosis;GO:0016477 cell migration;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9WV31-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1R3-1", "uniprot_id": [ { "id": "APOM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1R3", "type": "external" } ], "mass": 21273.0, "length": 190, "protein_name": "Apolipoprotein M", "gene_name": "Apom", "organism": "Mouse", "refseq_name": "apolipoprotein M precursor", "refseq_ac": [ { "id": "NP_061286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061286", "type": "external" } ], "gene_names_uniprotkb": "Apom; Ng20", "gene_names_refseq": "1190010O19Rik; Apom; G3a; NG20", "protein_names_uniprotkb": "Apolipoprotein M; Apo-M; ApoM", "protein_names_refseq": "apo-M; apolipoprotein M precursor", "tax_id": 10090, "disease": "coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:55938); (R-MMU-975634)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14656967;15102887;15147633;16099815;20932978", "class_list": "", "function": "ApoM mainly associates with HDL in normal mice but also with the pathologically increased lipoprotein fraction in genetically modified mice; decreased apoM levels in apoA-I-deficient mice suggest a connection between apoM and apoA-I metabolism., [RefSeq, PubMed]; ApoM transcripts were detectable in mouse embryos from day 7.5 to day 18.5, [RefSeq, PubMed]; Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle", "go_biological_process": "GO:0042157 lipoprotein metabolic process;GO:0033344 cholesterol efflux;GO:0034375 high-density lipoprotein particle remodeling;GO:0043691 reverse cholesterol transport;GO:0034380 high-density lipoprotein particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z1R3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14094-1", "uniprot_id": [ { "id": "AT1B1_MOUSE", "url": "https://www.uniprot.org/uniprot/P14094", "type": "external" } ], "mass": 35195.0, "length": 304, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1", "gene_name": "Atp1b1", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1", "refseq_ac": [ { "id": "NP_033851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033851", "type": "external" } ], "gene_names_uniprotkb": "Atp1b1; Atp4b", "gene_names_refseq": "Atp1b1; Atp4b; Atpb-1; Atpb; NKbeta1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1; Sodium/potassium-dependent ATPase subunit beta-1", "protein_names_refseq": "sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase subunit beta-1", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); essential hypertension (Disease Ontology:DOID:10825); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:11931); (R-MMU-210991); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12106288;15743908;17606467;18034455;19349973;21454534;21750661;23392350;2557580;26495903;28011936;30012868;30899004;33300544;33725478;34428180;36288343;37507081", "class_list": "", "function": "Involved in cell adhesion and establishing epithelial cell polarity., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]., [RefSeq]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 53, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046982 protein heterodimerization activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0043209 myelin sheath;GO:0014704 intercalated disc", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0001666 response to hypoxia;GO:0006874 intracellular calcium ion homeostasis;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 7.7, "record_id": "P14094-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PIC6-1", "uniprot_id": [ { "id": "AT1A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PIC6", "type": "external" } ], "mass": 111692.0, "length": 1013, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-3", "gene_name": "Atp1a3", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-3 isoform 2", "refseq_ac": [ { "id": "NP_001277398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277398", "type": "external" } ], "gene_names_uniprotkb": "Atp1a3", "gene_names_refseq": "Atp1a3; Atpa-2", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-3; 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Sodium pump subunit alpha-3", "protein_names_refseq": "Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; sodium pump subunit alpha-3; sodium/potassium-transporting ATPase subunit alpha-3 isoform 2; sodium/potassium-transporting ATPase subunit alpha-3", "tax_id": 10090, "disease": "alternating hemiplegia of childhood (Disease Ontology:DOID:0050635); familial hemiplegic migraine (Disease Ontology:DOID:0060178); developmental and epileptic encephalopathy 99 (Disease Ontology:DOID:0070385); dystonia 12 (Disease Ontology:DOID:0090056); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); bipolar disorder (Disease Ontology:DOID:3312); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:232975); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15648052;18034455;19666602;21183079;21750661;22645316;30899004;31219806;32301109;33300544;38804677;39111836;40684658", "class_list": "", "function": "ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress., [RefSeq, PubMed]; Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes (By similarity). In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:19666602)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Phenotype Distinctions in Mice Deficient in the Neuron-Specific alpha3 Subunit of Na,K-ATPase: Atp1a3[tm1Ling/+] and Atp1a3 [+/D801Y]. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 9, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046959 habituation;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007612 learning;GO:0007613 memory;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q6PIC6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPB4-1", "uniprot_id": [ { "id": "ASC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPB4", "type": "external" } ], "mass": 21459.0, "length": 193, "protein_name": "Apoptosis-associated speck-like protein containing a CARD", "gene_name": "Pycard", "organism": "Mouse", "refseq_name": "apoptosis-associated speck-like protein containing a CARD", "refseq_ac": [ { "id": "NP_075747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075747", "type": "external" } ], "gene_names_uniprotkb": "Pycard; Asc", "gene_names_refseq": "9130417A21Rik; Asc; CARD5; Pycard; TMS-1; TNS1; masc", "protein_names_uniprotkb": "Apoptosis-associated speck-like protein containing a CARD; PYD and CARD domain-containing protein; mASC", "protein_names_refseq": "PYD and CARD domain-containing protein; apoptosis-associated speck-like protein containing a CARD", "tax_id": 10090, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:66824); (R-MMU-5660668); (R-MMU-6798695); (R-MMU-844456)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11139337;15190255;15507117;21183079;21750661;21892172;22555457;26495903;26740625;27421477;28314590;30487600;32424362;34471287;34678144", "class_list": "", "function": "Cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways, [RefSeq, PubMed]; Functions as a key mediator in apoptosis and inflammation (PubMed:32424362, PubMed:34678144). Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner (By similarity). Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3 (By similarity). Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes (NLRP2, NLRP3, NLRP6 and AIM2) which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:15190255, PubMed:15507117, PubMed:21892172, PubMed:22555457, PubMed:32424362, PubMed:34678144). Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (By similarity). Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). In the NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1 (By similarity). In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation (By similarity). May be involved in RIGI-triggered pro-inflammatory responses and inflammasome activation (By similarity). In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8 (PubMed:22555457). In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways (By similarity). For regulation of NF-kappa-B activating and inhibiting functions have been reported (By similarity). Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK (By similarity). Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing (By similarity). Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2W9", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0044546 NLRP3 inflammasome complex assembly;GO:0007231 osmosensory signaling pathway;GO:0006954 inflammatory response;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EPB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35126-1", "uniprot_id": [ { "id": "ATN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35126", "type": "external" } ], "mass": 123724.0, "length": 1175, "protein_name": "Atrophin-1", "gene_name": "Atn1", "organism": "Mouse", "refseq_name": "atrophin-1", "refseq_ac": [ { "id": "NP_031907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031907", "type": "external" } ], "gene_names_uniprotkb": "Atn1; Drpla", "gene_names_refseq": "Atn1; Atr1; Drpla; atrophin-1", "protein_names_uniprotkb": "Atrophin-1; Dentatorubral-pallidoluysian atrophy protein homolog", "protein_names_refseq": "atrophin-1; dentatorubral pallidoluysian atrophy; dentatorubral-pallidoluysian atrophy protein homolog", "tax_id": 10090, "disease": "dentatorubral-pallidoluysian atrophy (Disease Ontology:DOID:0060162); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:13498)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;16702404;19039037;19131340;21183079;21750661;24129315;25428506;32782141;34887587;36852467;40885482;40997131;9070948;9445485", "class_list": "", "function": "Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P70200;Q80YQ0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0016477 cell migration;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O35126-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08664-1", "uniprot_id": [ { "id": "BCL7C_MOUSE", "url": "https://www.uniprot.org/uniprot/O08664", "type": "external" } ], "mass": 23445.0, "length": 217, "protein_name": "B-cell CLL/lymphoma 7 protein family member C", "gene_name": "Bcl7c", "organism": "Mouse", "refseq_name": "B-cell CLL/lymphoma 7 protein family member C isoform 2", "refseq_ac": [ { "id": "NP_033876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033876", "type": "external" } ], "gene_names_uniprotkb": "Bcl7c", "gene_names_refseq": "Bcl7c; C230096E12Rik", "protein_names_uniprotkb": "B-cell CLL/lymphoma 7 protein family member C; B-cell chronic lymphocytic leukemia/lymphoma 7C protein", "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member C isoform 2; B-cell CLL/lymphoma 7 protein family member C; B-cell chronic lymphocytic leukemia/lymphoma 7C protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12055); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "15270555;15345747;21183079;21750661;9931421", "class_list": "", "function": "May play an anti-apoptotic role., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99LS2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08664-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70444-1", "uniprot_id": [ { "id": "BID_MOUSE", "url": "https://www.uniprot.org/uniprot/P70444", "type": "external" } ], "mass": 21952.0, "length": 195, "protein_name": "BH3-interacting domain death agonist", "gene_name": "Bid", "organism": "Mouse", "refseq_name": "BH3-interacting domain death agonist", "refseq_ac": [ { "id": "NP_031570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031570", "type": "external" } ], "gene_names_uniprotkb": "Bid", "gene_names_refseq": "2700049M22Rik; Bid", "protein_names_uniprotkb": "BH3-interacting domain death agonist; BID; CCRF; Cytochrome c Releasing Factor; Truncated Bid; p11 BID; p13 BID; p22 BID; tBid", "protein_names_refseq": "BH3-interacting domain death agonist; p22 BID", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); traumatic brain injury (Disease Ontology:DOID:0081292); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:12122); (R-MMU-111447); (R-MMU-111452); (R-MMU-111453); (R-MMU-114294); (R-MMU-75108)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10089878;15899861;16606343;20392206;21750661;34428180;8918887;9727491;9727492;9873064", "class_list": "", "function": "Induces caspase activation and apoptosis (PubMed:9727491, PubMed:9727492). Translocates to mitochondria following cleavage and disrupts the outer mitochondrial membrane leading to the release of cytochrome c (PubMed:9727491, PubMed:9727492, PubMed:9873064)., [UniProtKB, PubMed, PubMed, PubMed]; Induces caspases and apoptosis. Counters the protective effect of BCL2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M39", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0031334 positive regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70444-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98200-1", "uniprot_id": [ { "id": "AT8A2_MOUSE", "url": "https://www.uniprot.org/uniprot/P98200", "type": "external" } ], "mass": 129417.0, "length": 1148, "protein_name": "Phospholipid-transporting ATPase IB", "gene_name": "Atp8a2", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase IB", "refseq_ac": [ { "id": "NP_056618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056618", "type": "external" } ], "gene_names_uniprotkb": "Atp8a2", "gene_names_refseq": "Atp8a2; Atpc1b; agil; wl", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IB; 7.6.2.1; ATPase class I type 8A member 2; P4-ATPase flippase complex alpha subunit ATP8A2", "protein_names_refseq": "ATPase 8A2, class I; ATPase 8A2, p type; ATPase class I type 8A member 2; ATPase, class 1, member a; P4-ATPase flippase complex alpha subunit ATP8A2; phospholipid-transporting ATPase IB; probable phospholipid-transporting ATPase IB", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4 (Disease Ontology:DOID:0070559)", "pathway": " (mmu:50769); (R-MMU-936837)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11015572;19778899;21183079;21750661;22641037;22912588;24413176;30084848;34428180", "class_list": "", "function": "Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22912588). Able to translocate phosphatidylserine, but not phosphatidylcholine (By similarity). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:22912588). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth (PubMed:22641037). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (PubMed:24413176)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9896, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RQF2", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:0042472 inner ear morphogenesis;GO:0042755 eating behavior", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P98200-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97450-1", "uniprot_id": [ { "id": "ATP5J_MOUSE", "url": "https://www.uniprot.org/uniprot/P97450", "type": "external" } ], "mass": 12496.0, "length": 108, "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "Atp5pf", "organism": "Mouse", "refseq_name": "ATP synthase peripheral stalk subunit F6, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001289142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289142", "type": "external" } ], "gene_names_uniprotkb": "Atp5pf; Atp5j", "gene_names_refseq": "Atp5j; Atp5pf; CF6", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit F6, mitochondrial; ATP synthase peripheral stalk subunit F6; ATPase subunit F6", "protein_names_refseq": "ATP synthase coupling factor VI; ATP synthase peripheral stalk subunit F6, mitochondrial precursor; ATP synthase peripheral stalk subunit F6, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F; ATP synthase-coupling factor 6, mitochondrial; ATPase subunit F6", "tax_id": 10090, "disease": "essential hypertension (Disease Ontology:DOID:10825); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:11957); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "16309857;20811295;21750661;21913724;22038518;22258022;22306848;22645316;22872234;23576753;23806337;25605945;28935714;31219806;32152506;33649389;34428180;35820727", "class_list": "", "function": "CF6 plays a crucial role in the development of insulin resistance and hypertension, [RefSeq, PubMed]; Coupling factor 6 induces the development of systolic dysfunction and upregulation of nicotinamide adenine dinucleotide phosphate oxidase in the heart under the high-salt diet, [RefSeq, PubMed]; Coupling factor 6 overexpression induced salt-sensitive hypertension, complicated by systolic cardiac dysfunction, but its onset was delayed in females. Estrogen has an important role in the regulation of coupling factor 6-mediated pathophysiology., [RefSeq, PubMed]; Identification of functional elements in bi-directional promoter, [RefSeq, PubMed]; Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by downregulating Akt signaling, thereby cancelling its benefit for cardiac function in mice., [RefSeq, PubMed]; Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0009986 cell surface", "go_biological_process": "GO:1900139 negative regulation of arachidonate secretion;GO:0045777 positive regulation of blood pressure;GO:0010460 positive regulation of heart rate;GO:0032307 negative regulation of prostaglandin secretion;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97450-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03930-1", "uniprot_id": [ { "id": "ATP8_MOUSE", "url": "https://www.uniprot.org/uniprot/P03930", "type": "external" } ], "mass": 7766.0, "length": 67, "protein_name": "ATP synthase F(0) complex subunit 8", "gene_name": "Mtatp8", "organism": "Mouse", "refseq_name": "ATP synthase F0 subunit 8", "refseq_ac": [ { "id": "NP_904332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_904332", "type": "external" } ], "gene_names_uniprotkb": "Mtatp8; Atp8; mt-Atp8", "gene_names_refseq": "ATP8", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit 8; A6L; F-ATPase subunit 8", "protein_names_refseq": "ATP synthase F0 subunit 8", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:17706); (R-MMU-163210); (R-MMU-5419276); (R-MMU-8949613)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12954771;23576753;23806337;33300544;34428180;37453647;39927985;7332926", "class_list": "", "function": "Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P03930-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06185-1", "uniprot_id": [ { "id": "ATP5I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06185", "type": "external" } ], "mass": 8236.0, "length": 71, "protein_name": "ATP synthase F(0) complex subunit e, mitochondrial", "gene_name": "Atp5me", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit e, mitochondrial", "refseq_ac": [ { "id": "NP_031533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031533", "type": "external" } ], "gene_names_uniprotkb": "Atp5me; Atp5i; Atp5k; Lfm-1; Lfm1", "gene_names_refseq": "2610008D24Rik; Atp5i; Atp5k; Atp5me; Lfm1", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit e, mitochondrial; ATP synthase membrane subunit e; ATPase subunit e", "protein_names_refseq": "ATP synthase F(0) complex subunit e, mitochondrial; ATP synthase subunit e, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E; ATPase subunit e", "tax_id": 10090, "disease": "", "pathway": " (mmu:11958); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "23576753;25605945;26495903;31219806;34428180;36288343;37453647;37507081;37828378;7678489;8702853", "class_list": "", "function": "Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70342", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q06185-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFX2-1", "uniprot_id": [ { "id": "BEND6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFX2", "type": "external" } ], "mass": 31270.0, "length": 281, "protein_name": "BEN domain-containing protein 6", "gene_name": "Bend6", "organism": "Mouse", "refseq_name": "BEN domain-containing protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001297413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297413", "type": "external" } ], "gene_names_uniprotkb": "Bend6", "gene_names_refseq": "B230209C24Rik; Bend6", "protein_names_uniprotkb": "BEN domain-containing protein 6", "protein_names_refseq": "BEN domain-containing protein 6 isoform 2; BEN domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:320705)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23571214;25561495", "class_list": "", "function": "Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214, PubMed:25561495)., [UniProtKB, PubMed, PubMed]; BEND6 knock down increases neural stem cell self-renewal in neocortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLC9;Q8BXN2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PFX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UQ17-1", "uniprot_id": [ { "id": "AT8B3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6UQ17", "type": "external" } ], "mass": 151955.0, "length": 1335, "protein_name": "Phospholipid-transporting ATPase IK", "gene_name": "Atp8b3", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase IK", "refseq_ac": [ { "id": "NP_080370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080370", "type": "external" } ], "gene_names_uniprotkb": "Atp8b3", "gene_names_refseq": "1700042F02Rik; 1700056N23Rik; ATPIK; Atp8b3; SAPLT", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IK; 7.6.2.1; ATPase, class I, type 8B, member 3; SAPLT; Sperm aminophospholipid transporter", "protein_names_refseq": "phospholipid-transporting ATPase IK; sperm aminophospholipid transporter; spermatozoan aminophospholipid translocase", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:67331); (R-MMU-936837)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14975727;17971504;19017724;31219806;34428180", "class_list": "", "function": "Atp8b3 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:14975727, PubMed:19017724). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (PubMed:14975727). May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes (PubMed:14975727). Involved in acrosome reactions and binding of spermatozoa to zona pellucida (PubMed:19017724)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090556 phosphatidylserine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6UQ17-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z10-1", "uniprot_id": [ { "id": "ASTN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Z10", "type": "external" } ], "mass": 149390.0, "length": 1352, "protein_name": "Astrotactin-2", "gene_name": "Astn2", "organism": "Mouse", "refseq_name": "astrotactin-2 isoform a", "refseq_ac": [ { "id": "NP_062387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062387", "type": "external" } ], "gene_names_uniprotkb": "Astn2; Kiaa0634", "gene_names_refseq": "1d8; Astn2; Astnl; bM452J22.1", "protein_names_uniprotkb": "Astrotactin-2", "protein_names_refseq": "astrotactin-2 isoform a; bM243L4.1 (astrotactin 2); bM264P11.1 (astrotactin 2); bM383P24.1 (astrotactin 2); bM423P8.1 (astrotactin 2); bM468K2.1 (astrotactin 2)", "tax_id": 10090, "disease": "", "pathway": " (mmu:56079)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;20573900;30084848;30779550;30899004;33300544;34203471;34428180;36807153", "class_list": "", "function": "ASTN2 regulates the levels of ASTN1 in the plasma membrane and that the release of neuronal adhesions to the glial fiber during neuronal locomotion involves the intracellular trafficking of ASTN1., [RefSeq, PubMed]; Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems., [RefSeq, PubMed]; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (PubMed:20573900). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9Q8T4;Q6A031;Q811X9;Q811Y0;Q811Y1;Q811Y2", "ec_number_list": [], "go_molecular_function": "GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005938 cell cortex;GO:0016020 membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0015031 protein transport;GO:0001764 neuron migration;GO:2000009 negative regulation of protein localization to cell surface;GO:0048105 establishment of body hair planar orientation;GO:0007158 neuron cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80Z10-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MY8-1", "uniprot_id": [ { "id": "ASH1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MY8", "type": "external" } ], "mass": 331333.0, "length": 2958, "protein_name": "Histone-lysine N-methyltransferase ASH1L", "gene_name": "Ash1l", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase ASH1L", "refseq_ac": [ { "id": "NP_619620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619620", "type": "external" } ], "gene_names_uniprotkb": "Ash1l", "gene_names_refseq": "8030453L17Rik; Ash1l; Ash1; E430018P19Rik; Kmt2h", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase ASH1L; 2.1.1.359; 2.1.1.367; ASH1-like protein; Absent small and homeotic disks protein 1 homolog", "protein_names_refseq": "ASH1-like protein; absent small and homeotic disks protein 1 homolog; absent, small, or homeotic discs 1; ash1 (absent, small, or homeotic)-like; chromatin remodeling factor; histone-lysine N-methyltransferase ASH1L; probable histone-lysine N-methyltransferase ASH1L", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 52 (Disease Ontology:DOID:0080231); leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:192195); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "17544230;18299400;21183079;21952136;22872234;22939622;23576753;25428506;30084848;34203471;34428180;35820727;36094439;37766518;37828378;39390582;40021952", "class_list": "", "function": "ASH1 mono- or di-methylates histone H3 K36 but not any other lysine residues of recombinant unmodified mammalian histones, [RefSeq, PubMed]; ASH1L contributes to oocyte apoptosis by regulating DNA damage., [RefSeq, PubMed]; Ash1L ameliorates psoriasis via limiting neuronal activity-dependent release of miR-let-7b., [RefSeq, PubMed]; Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (By similarity). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The physiological significance of the H3K9me1 activity is unclear (Probable) (PubMed:22939622)., [UniProtKB, UniProtKB, PubMed]; Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNM2;Q3U598;Q80VY5;Q8BM69;Q8BTX0;Q8BZY6", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005923 bicellular tight junction;GO:0016604 nuclear body", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002674 negative regulation of acute inflammatory response;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q99MY8-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54689-1", "uniprot_id": [ { "id": "CCR6_MOUSE", "url": "https://www.uniprot.org/uniprot/O54689", "type": "external" } ], "mass": 42103.0, "length": 367, "protein_name": "C-C chemokine receptor type 6", "gene_name": "Ccr6", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 6 isoform A", "refseq_ac": [ { "id": "NP_001177262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177262", "type": "external" } ], "gene_names_uniprotkb": "Ccr6; Cmkbr6", "gene_names_refseq": "CC-CKR-6; CCR-6; Ccr6; Cmkbr6; KY411", "protein_names_uniprotkb": "C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; KY411", "protein_names_refseq": "C-C chemokine receptor type 6 isoform A; C-C chemokine receptor type 6; chemokine (C-C motif) receptor 6", "tax_id": 10090, "disease": "exanthem (Disease Ontology:DOID:0050486); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); fungal infectious disease (Disease Ontology:DOID:1564); breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); IgA glomerulonephritis (Disease Ontology:DOID:2986); systemic scleroderma (Disease Ontology:DOID:418); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:12458); (R-MMU-1461957); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "19050256;19129757;20068036;21376174;21750661;23765988;24638065;25122636;25505290;27174992;9862452", "class_list": "", "function": "Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25122636). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine (PubMed:19129757). Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors (PubMed:24638065). Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches (PubMed:27174992). Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (PubMed:25505290). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; This gene is a mouse CC chemokine receptor CCR6 but not carbon catabolite repression 6. The definition line of the GenBank file (AB009639) has been corrected as G protein-coupled receptor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0002523 leukocyte migration involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O54689-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89094-1", "uniprot_id": [ { "id": "CASPE_MOUSE", "url": "https://www.uniprot.org/uniprot/O89094", "type": "external" } ], "mass": 29458.0, "length": 257, "protein_name": "Caspase-14", "gene_name": "Casp14", "organism": "Mouse", "refseq_name": "caspase-14", "refseq_ac": [ { "id": "NP_033939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033939", "type": "external" } ], "gene_names_uniprotkb": "Casp14", "gene_names_refseq": "Casp14; MICE; mini-ICE", "protein_names_uniprotkb": "Caspase-14; 3.4.22.-; CASP-14; MICE; Mini-ICE", "protein_names_refseq": "CASP-14; caspase-14", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis (Disease Ontology:DOID:0060655)", "pathway": " (mmu:12365); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10203698;11175259;11526440;12200134;17515931;18156206;21654840;24872419;34428180;9792675;9823333", "class_list": "", "function": "Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification (PubMed:18156206). Regulates maturation of the epidermis by proteolytically processing filaggrin (PubMed:21654840). In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis (PubMed:24872419). May be involved in retinal pigment epithelium cell barrier function (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Processing of caspase 14 in epidermal differentiation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" } ], "go_molecular_function": "GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0030154 cell differentiation;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O89094-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16015-1", "uniprot_id": [ { "id": "CAH3_MOUSE", "url": "https://www.uniprot.org/uniprot/P16015", "type": "external" } ], "mass": 29366.0, "length": 260, "protein_name": "Carbonic anhydrase 3", "gene_name": "Ca3", "organism": "Mouse", "refseq_name": "carbonic anhydrase 3", "refseq_ac": [ { "id": "NP_031632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031632", "type": "external" } ], "gene_names_uniprotkb": "Ca3; Car3", "gene_names_refseq": "Ca3; Car-3; Car3", "protein_names_uniprotkb": "Carbonic anhydrase 3; 4.2.1.1; CA-III; Carbonate dehydratase III; Carbonic anhydrase III", "protein_names_refseq": "CA-III; carbonate dehydratase III; carbonic anhydrase 3; carbonic anhydrase III", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); lesion of sciatic nerve (Disease Ontology:DOID:12528); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12350); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11255005;1922100;21183079;2496681;34428180;37453647;37507081;39927985", "class_list": "", "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERN8", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016791 phosphatase activity;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0003009 skeletal muscle contraction;GO:0006979 response to oxidative stress;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16015-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29452-1", "uniprot_id": [ { "id": "CASP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P29452", "type": "external" } ], "mass": 45640.0, "length": 402, "protein_name": "Caspase-1", "gene_name": "Casp1", "organism": "Mouse", "refseq_name": "caspase-1", "refseq_ac": [ { "id": "NP_033937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033937", "type": "external" } ], "gene_names_uniprotkb": "Casp1; Il1bc", "gene_names_refseq": "Casp1; ICE; Il1bc", "protein_names_uniprotkb": "Caspase-1; 3.4.22.36; CASP-1; ICE; IL-1 beta-converting enzyme; IL-1BC; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45", "protein_names_refseq": "CASP-1; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; caspase-1; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:12362); (R-MMU-168638); (R-MMU-448706); (R-MMU-5620971)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "1431103;18667412;21147462;21183079;21750661;22464733;24129315;25605945;28314590;30692621;31219806;32109412;34428180;34471287;35705808;8034321;8446594;9038361", "class_list": "", "function": "Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:21147462, PubMed:32109412). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:21147462). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:21147462). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:32109412). In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:18667412, PubMed:22464733, PubMed:35705808). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "3.4.22.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.64", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0097110 scaffold protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0032730 positive regulation of interleukin-1 alpha production;GO:0070498 interleukin-1-mediated signaling pathway;GO:0032741 positive regulation of interleukin-18 production;GO:0002221 pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P29452-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56388-1", "uniprot_id": [ { "id": "CART_MOUSE", "url": "https://www.uniprot.org/uniprot/P56388", "type": "external" } ], "mass": 14285.0, "length": 129, "protein_name": "Cocaine- and amphetamine-regulated transcript protein", "gene_name": "Cartpt", "organism": "Mouse", "refseq_name": "cocaine- and amphetamine-regulated transcript protein isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_038760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038760", "type": "external" } ], "gene_names_uniprotkb": "Cartpt; Cart", "gene_names_refseq": "Cartpt; Cart", "protein_names_uniprotkb": "Cocaine- and amphetamine-regulated transcript protein", "protein_names_refseq": "cocaine- and amphetamine-regulated transcript protein isoform 1 preproprotein; cocaine- and amphetamine-regulated transcript protein", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); amnestic disorder (Disease Ontology:DOID:10914); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); cerebral infarction (Disease Ontology:DOID:3526); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:27220)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10612705;11882520;12584191;21183079", "class_list": "", "function": "Leptin modulates arcuate cocaine- and amphetamine-regulated transcript expression in obese A(y)/a mice, [RefSeq, PubMed]; Processing of pro-CART revealed that PC2 is more potent than PC1/3 in generating bioactive CART I; bioactive CART II is solely generated by PC2; and PC1/3 is predominantly active in liberating the two intermediate CART fragments, 33-102 and 10-89., [RefSeq, PubMed]; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus., [UniProtKB]; This gene encodes preproprotein isoforms that are processed into multiple biologically active peptides. Expression of this gene is regulated by cocaine and other drugs, and is associated with feeding/appetite and stress response. Mice lacking the encoded protein are predisposed to obesity. Deficiency of the encoded protein in mice results in pancreatic islet dysfunction, impaired insulin secretion and glucose intolerance. Alternative splicing results in multiple transcript variants encoding different isoforms, which are subsequently processed into mature peptides. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXZ8", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0090325 regulation of locomotion involved in locomotory behavior;GO:0035106 operant conditioning;GO:1903999 negative regulation of eating behavior;GO:0006171 cAMP biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56388-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZU5-1", "uniprot_id": [ { "id": "CC181_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZU5", "type": "external" } ], "mass": 59241.0, "length": 509, "protein_name": "Coiled-coil domain-containing protein 181", "gene_name": "Ccdc181", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 181", "refseq_ac": [ { "id": "NP_083391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083391", "type": "external" } ], "gene_names_uniprotkb": "Ccdc181", "gene_names_refseq": "4930455F23Rik; Ccdc181", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 181", "protein_names_refseq": "coiled-coil domain-containing protein 181", "tax_id": 10090, "disease": "", "pathway": " (mmu:74895)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;28283191;39019207;39245650", "class_list": "", "function": "4930455F23Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; CCDC181 is required for sperm flagellum biogenesis and male fertility in mice., [RefSeq, PubMed]; Ccdc181 is a binding partner of Hook1. Ccdc181 localizes to the sperm flagella and to the basal half of motile cilia., [RefSeq, PubMed]; Microtubule-binding protein that is essential for the integrity and function of the manchette, facilitating proper sperm head shaping and subsequent flagellum formation during spermatogenesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF07;Q8C631;Q9CUL9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0002177 manchette;GO:0005930 axoneme", "go_biological_process": "GO:0007286 spermatid development;GO:1905198 manchette assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ89-1", "uniprot_id": [ { "id": "CCD86_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ89", "type": "external" } ], "mass": 46487.0, "length": 426, "protein_name": "Coiled-coil domain-containing protein 86", "gene_name": "Ccdc86", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 86", "refseq_ac": [ { "id": "NP_076220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076220", "type": "external" } ], "gene_names_uniprotkb": "Ccdc86; Cyclon; D19Ertd678e; MNCb-4327", "gene_names_refseq": "4933411H20Rik; 6720480F16Rik; Ccdc86; D19Ertd678e", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 86; Cytokine-induced protein with coiled-coil domain; mCyclon", "protein_names_refseq": "coiled-coil domain-containing protein 86; cyclon; cytokine-induced protein with coiled-coil domain; mCyclon", "tax_id": 10090, "disease": "", "pathway": " (mmu:108673)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;17300783;19528538;21183079;24463520", "class_list": "", "function": "Cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus, [RefSeq, PubMed]; Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon., [RefSeq, PubMed]; Required for proper chromosome segregation during mitosis and error-free mitotic progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGH9;Q8C2F2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation;GO:0140014 mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJ89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AMM0-1", "uniprot_id": [ { "id": "CAVN4_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AMM0", "type": "external" } ], "mass": 41008.0, "length": 362, "protein_name": "Caveolae-associated protein 4", "gene_name": "Cavin4", "organism": "Mouse", "refseq_name": "caveolae-associated protein 4", "refseq_ac": [ { "id": "NP_080785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785", "type": "external" } ], "gene_names_uniprotkb": "Cavin4; Murc", "gene_names_refseq": "2310039E09Rik; Cavin4; Murc", "protein_names_uniprotkb": "Caveolae-associated protein 4; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein", "protein_names_refseq": "caveolae-associated protein 4; cavin 4; muscle-related coiled-coil protein; muscle-restricted coiled-coil protein", "tax_id": 10090, "disease": "muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:68016)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18332105;18508909;19546242;21183079;24567387;26497963;27546070;28433630;31364493;34633413;36288343;37507081", "class_list": "", "function": "Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle., [RefSeq, PubMed]; Data show that MURC/Cavin-4 forms a multiprotein complex that associates with caveolae, and identify Cavin-4 as a novel muscle disease candidate caveolar protein., [RefSeq, PubMed]; Findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation; MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation, [RefSeq, PubMed]; MURC binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13, resulting in the facilitated association of the active form of Galpha13 with p115RhoGEF. These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling. Publication Status: Online-Only, [RefSeq, PubMed]; MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias., [RefSeq, PubMed]; MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors., [RefSeq, PubMed]; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387). Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105)., [UniProtKB, PubMed, PubMed, PubMed]; Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury., [RefSeq, PubMed]; The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA) progression at the early stage via the activation of JNK and MMP-9. MURC/Cavin-4 is a potential therapeutic target against AAA progression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1PRL4;Q5FW67;Q9CV87;Q9D728", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007266 Rho protein signal transduction;GO:0007517 muscle organ development;GO:0055003 cardiac myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A2AMM0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810N9-1", "uniprot_id": [ { "id": "CC172_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810N9", "type": "external" } ], "mass": 31483.0, "length": 267, "protein_name": "Coiled-coil domain-containing protein 172", "gene_name": "Ccdc172", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 172 isoform 1", "refseq_ac": [ { "id": "NP_083648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083648", "type": "external" } ], "gene_names_uniprotkb": "Ccdc172; Tekt2bp1", "gene_names_refseq": "1700011F14Rik; Ccdc172", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 172; TEKT2-binding protein 2", "protein_names_refseq": "TEKT2-binding protein 2; UPF0628 protein C10orf96 homolog; coiled-coil domain-containing protein 172 isoform 1; coiled-coil domain-containing protein 172", "tax_id": 10090, "disease": "", "pathway": " (mmu:75645)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24394471", "class_list": "", "function": "TEKT2BP1 was predominantly expressed in rat testis and that its expression was increased after 3 weeks of postnatal development; a isolated and identified TEKT2BP1 (Ccdc172) as a partner of TEKT2 by yeast two-hybrid screening, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAG3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097225 sperm midpiece", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810N9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWF2-1", "uniprot_id": [ { "id": "GIMA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWF2", "type": "external" } ], "mass": 34653.0, "length": 308, "protein_name": "GTPase IMAP family member 5", "gene_name": "Gimap5", "organism": "Mouse", "refseq_name": "GTPase IMAP family member 5", "refseq_ac": [ { "id": "NP_778200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778200", "type": "external" } ], "gene_names_uniprotkb": "Gimap5; Ian4l1; Ian5; Imap3", "gene_names_refseq": "D630024P16; E230026N22Rik; Gimap5", "protein_names_uniprotkb": "GTPase IMAP family member 5; GTPase of the immunity-associated protein 5; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated protein 3", "protein_names_refseq": "GTPase IMAP family member 5; GTPase of the immunity-associated protein 5; immunity-associated nucleotide 4-like 1 protein; immunity-associated protein 3", "tax_id": 10090, "disease": "portal hypertension (Disease Ontology:DOID:10762); lymphopenia (Disease Ontology:DOID:614); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:317757)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16509771;18796632;21487483;21502331;25808953;25944983;26495903;27023180;28011936;29382851;30616774;33956074", "class_list": "", "function": "Activation of Gimap5-deficient CD4(+) T cells is associated with increased DNA damage and reduced survival that can be overcome by TGF-beta. This leads to selective survival of pathogenic TH17 cells but also TH2 cells in human subjects and mice, ultimately promoting allergic airway disease., [RefSeq, PubMed]; Functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. Publication Status: Online-Only, [RefSeq, PubMed]; GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension., [RefSeq, PubMed]; Gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] Review article, [RefSeq, PubMed]; Gimap5 is a critical inhibitor of GSK3-beta in the CD4+ T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, and the maintenance of normal liver function, [RefSeq, PubMed]; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (PubMed:16509771). Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (PubMed:18796632, PubMed:21502331). May promote the survival of mature T lymphocytes upon cytokine withdrawal (PubMed:16509771). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953). Is a regulator of liver endothelial cell homeostasis (PubMed:33956074)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q501L7;Q549X3", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005765 lysosomal membrane;GO:0032585 multivesicular body membrane", "go_biological_process": "GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0001659 temperature homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BWF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MI6-1", "uniprot_id": [ { "id": "GIMA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MI6", "type": "external" } ], "mass": 34179.0, "length": 301, "protein_name": "GTPase IMAP family member 3", "gene_name": "Gimap3", "organism": "Mouse", "refseq_name": "GTPase IMAP family member 3", "refseq_ac": [ { "id": "NP_112537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112537", "type": "external" } ], "gene_names_uniprotkb": "Gimap3; Ian4", "gene_names_refseq": "2010110D23Rik; Gimap3; Gimap5; Ian4", "protein_names_uniprotkb": "GTPase IMAP family member 3; IAN-4; Immunity-associated nucleotide 4 protein", "protein_names_refseq": "GTPase IMAP family member 3; IAN-4; immune associated nucleotide 4; immunity-associated nucleotide 4 protein", "tax_id": 10090, "disease": "portal hypertension (Disease Ontology:DOID:10762); lymphopenia (Disease Ontology:DOID:614); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:83408)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11238997;16509771;20976251;24510501;25808953", "class_list": "", "function": "Data shsow that Gimap3 is important for T cell development and survival, suggesting that leukocyte survival may be a key factor in the genetic regulation of mtDNA sequence variants and in modulating human mitochondrial diseases. Publication Status: Online-Only, [RefSeq, PubMed]; During thymocyte development, may support the positive selection of CD4 and CD8 T cells (PubMed:16509771). May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953). Binds GTP (PubMed:11238997)., [UniProtKB, PubMed, PubMed, PubMed]; Quantitative changes in expression of Gimap3 and the paralogue Gimap5 affect mtDNA segregation in hematopoietic tissues. Gimap3 localizes to the endoplasmic reticulum and not mitochondria., [RefSeq, PubMed]; The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5., [RefSeq, PubMed]; This gene encodes a mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The expression of this gene is induced in BCR/ABL-expressing cells. The encoded protein lacks an N-terminal mitochondrial signal sequence. Experimental studies showed that mitochondrial localization relies on the C-terminal transmembrane domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1 [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBX0;Q549W4;Q8CF04", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0001659 temperature homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99MI6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZB7-1", "uniprot_id": [ { "id": "ARP10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZB7", "type": "external" } ], "mass": 46208.0, "length": 417, "protein_name": "Actin-related protein 10", "gene_name": "Actr10", "organism": "Mouse", "refseq_name": "actin-related protein 10", "refseq_ac": [ { "id": "NP_062759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062759", "type": "external" } ], "gene_names_uniprotkb": "Actr10; Act11; Actr11; Arp10; Arp11", "gene_names_refseq": "Actr10; Actr11; Arp11", "protein_names_uniprotkb": "Actin-related protein 10; Actin-related protein 11", "protein_names_refseq": "ARP10 actin-related protein 10 homolog; actin-related protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:56444); (R-MMU-2132295); (R-MMU-3371497); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-6811436)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10525537;21750661;30084848;31219806;33300544;34203471;34428180;35820727;36210013", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT18;Q99LU1", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005869 dynactin complex;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0098958 retrograde axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QZB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0E3-1", "uniprot_id": [ { "id": "AIRE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0E3", "type": "external" } ], "mass": 59042.0, "length": 552, "protein_name": "Autoimmune regulator", "gene_name": "Aire", "organism": "Mouse", "refseq_name": "autoimmune regulator isoform 2", "refseq_ac": [ { "id": "NP_001258478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258478", "type": "external" } ], "gene_names_uniprotkb": "Aire", "gene_names_refseq": "Aire", "protein_names_uniprotkb": "Autoimmune regulator; APECED protein homolog; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog", "protein_names_refseq": "APECED protein homolog; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; autoimmune regulator isoform 2", "tax_id": 10090, "disease": "autoimmune polyendocrine syndrome type 1 (Disease Ontology:DOID:0050167); Guillain-Barre syndrome (Disease Ontology:DOID:12842); Sjogren's syndrome (Disease Ontology:DOID:12894); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040)", "pathway": " (mmu:11634)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10022980;10049587;10049735;10550218;10593569;11156688;11533054;18840680;19015306;19302042;19923453;21300913;21750661;23993652;26070482;30084848", "class_list": "", "function": "Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306). Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913). Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453). In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482). In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLW0;Q9JLW1;Q9JLW2;Q9JLW3;Q9JLW4;Q9JLW5;Q9JLW6;Q9JLW7;Q9JLW8;Q9JLW9;Q9JLX0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0032722 positive regulation of chemokine production;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z0E3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UX43-1", "uniprot_id": [ { "id": "AN13C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UX43", "type": "external" } ], "mass": 60150.0, "length": 541, "protein_name": "Ankyrin repeat domain-containing protein 13C", "gene_name": "Ankrd13c", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 13C isoform 1", "refseq_ac": [ { "id": "NP_001013828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013828", "type": "external" } ], "gene_names_uniprotkb": "Ankrd13c", "gene_names_refseq": "Ankrd13c", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 13C", "protein_names_refseq": "ankyrin repeat domain-containing protein 13C isoform 1; ankyrin repeat domain-containing protein 13C", "tax_id": 10090, "disease": "", "pathway": " (mmu:433667)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RST2;Q6P1G4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0071799 cellular response to prostaglandin D stimulus;GO:2000209 regulation of anoikis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UX43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U108-1", "uniprot_id": [ { "id": "ARI5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U108", "type": "external" } ], "mass": 63898.0, "length": 590, "protein_name": "AT-rich interactive domain-containing protein 5A", "gene_name": "Arid5a", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 5A isoform 1", "refseq_ac": [ { "id": "NP_001165676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165676", "type": "external" } ], "gene_names_uniprotkb": "Arid5a", "gene_names_refseq": "Arid5a; D430024K22Rik; Mrf1", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 5A; ARID domain-containing protein 5A", "protein_names_refseq": "ARID domain-containing protein 5A; AT rich interactive domain 5A (MRF1-like); AT rich interactive domain 5A (Mrf1 like); AT-rich interactive domain-containing protein 5A isoform 1; AT-rich interactive domain-containing protein 5A; modulator recognition factor I", "tax_id": 10090, "disease": "", "pathway": " (mmu:214855)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "21183079;21346191;21750661;23676272;24782182;27022145;27671645;28168301;29244194;30084848;31219806;31599954;34389433;34428180;35940634;36454447", "class_list": "", "function": "AT-rich interactive domain-containing protein 5a (Arid5a) cooperates with Sox9 to stimulate chondrocyte-specific transcription., [RefSeq, PubMed]; Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense., [RefSeq, PubMed]; Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo., [RefSeq, PubMed]; Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited., [RefSeq, PubMed]; DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (By similarity). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (PubMed:21346191). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (By similarity). As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21. Also stabilizes IL6 mRNA. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells (PubMed:23676272, PubMed:27022145). In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling (PubMed:24782182). Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (PubMed:27671645). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (PubMed:29244194)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice., [RefSeq, PubMed]; T cell-intrinsic role of Arid5a on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 mRNA., [RefSeq, PubMed]; The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZS4;Q3U0F0;Q3U0S2;Q3UDA3;Q3UDZ6;Q8BI45;Q8BYB5;Q8R2W1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:0032740 positive regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3U108-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WQ6-1", "uniprot_id": [ { "id": "RHDF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WQ6", "type": "external" } ], "mass": 93434.0, "length": 827, "protein_name": "Inactive rhomboid protein 2", "gene_name": "Rhbdf2", "organism": "Mouse", "refseq_name": "inactive rhomboid protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001161152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161152", "type": "external" } ], "gene_names_uniprotkb": "Rhbdf2; Irhom2; Rhbdl6; Rhor", "gene_names_refseq": "4732465I17Rik; Rhbdf2; Rhbdl6; Uncv; cub", "protein_names_uniprotkb": "Inactive rhomboid protein 2; Rhomboid family member 2; Rhomboid veinlet-like protein 6; Rhomboid-related protein; iRhom2", "protein_names_refseq": "iRhom2; inactive rhomboid protein 2 isoform 1; inactive rhomboid protein 2; rhomboid family member 2; rhomboid veinlet-like protein 6; rhomboid, veinlet-like 6; rhomboid-like protein 6; rhomboid-related protein; uncovered", "tax_id": 10090, "disease": "palmoplantar keratoderma-esophageal carcinoma syndrome (Disease Ontology:DOID:0111506)", "pathway": " (mmu:217344)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21439629;30899004;38183983;38570362;38892263;39134731", "class_list": "", "function": "Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway., [RefSeq, PubMed]; IRhom2 deficiency reduces sepsis-induced mortality associated with the attenuation of lung macrophages in mice., [RefSeq, PubMed]; IRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation (PubMed:21439629). Does not exhibit any protease activity on its own (PubMed:21439629)., [UniProtKB, PubMed]; Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBR9;Q8BJ70;Q8K2I7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0015031 protein transport;GO:0072659 protein localization to plasma membrane;GO:0050708 regulation of protein secretion;GO:0042058 regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80WQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CSN1-1", "uniprot_id": [ { "id": "SNW1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CSN1", "type": "external" } ], "mass": 61475.0, "length": 536, "protein_name": "SNW domain-containing protein 1", "gene_name": "Snw1", "organism": "Mouse", "refseq_name": "SNW domain-containing protein 1", "refseq_ac": [ { "id": "NP_079783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079783", "type": "external" } ], "gene_names_uniprotkb": "Snw1; Skiip", "gene_names_refseq": "2310008B08Rik; NCoA-62; SKIP; Skiip; Snw1", "protein_names_uniprotkb": "SNW domain-containing protein 1; Nuclear protein SkiP; Ski-interacting protein", "protein_names_refseq": "SKI interacting protein; SNW domain-containing protein 1; nuclear protein SkiP; ski-interacting protein", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); breast carcinoma (Disease Ontology:DOID:3459); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:66354); (R-MMU-2122947); (R-MMU-2173795); (R-MMU-350054); (R-MMU-72163); (R-MMU-8941856)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12529369;15878163;17592128;19131326;19144319;21183079;21750661;31219806;31927035;33388413;34428180;34887587;36210013", "class_list": "", "function": "Interaction with vitamin D receptor helix H10 residues, [RefSeq, PubMed]; Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD., [UniProtKB, UniProtKB]; Involved in pre-mRNA splicing., [UniProtKB, UniProtKB]; Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations., [RefSeq, PubMed]; Skip participates in formation and lipid metabolism of beige adipose and might mediate the effects of SIRT1 activator BTM-0512 on beige remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0005112 Notch binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016604 nuclear body", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CSN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZW5-1", "uniprot_id": [ { "id": "SH2D5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZW5", "type": "external" } ], "mass": 47380.0, "length": 429, "protein_name": "SH2 domain-containing protein 5", "gene_name": "Sh2d5", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 5", "refseq_ac": [ { "id": "NP_001093101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093101", "type": "external" } ], "gene_names_uniprotkb": "Sh2d5", "gene_names_refseq": "Sh2d5", "protein_names_uniprotkb": "SH2 domain-containing protein 5", "protein_names_refseq": "SH2 domain-containing protein 5; vascular SH2 domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:230863)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25331951;31219806;34428180", "class_list": "", "function": "May be involved in synaptic plasticity regulation through the control of Rac-GTP levels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0014069 postsynaptic density", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JZW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM98-1", "uniprot_id": [ { "id": "WRP73_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM98", "type": "external" } ], "mass": 52053.0, "length": 462, "protein_name": "WD repeat-containing protein WRAP73", "gene_name": "Wrap73", "organism": "Mouse", "refseq_name": "WD repeat-containing protein WRAP73", "refseq_ac": [ { "id": "NP_067474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067474", "type": "external" } ], "gene_names_uniprotkb": "Wrap73; Dd57; Wdr8", "gene_names_refseq": "2610044M17Rik; 5330425N03Rik; Dd57; Wdr8; Wrap73", "protein_names_uniprotkb": "WD repeat-containing protein WRAP73; WD repeat-containing protein 8; WD repeat-containing protein antisense to TP73 gene", "protein_names_refseq": "WD repeat domain 8; WD repeat-containing protein 8; WD repeat-containing protein WRAP73; WD repeat-containing protein antisense to TP73", "tax_id": 10090, "disease": "", "pathway": " (mmu:59002)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11401440;21750661;26675238;31219806;34428180", "class_list": "", "function": "The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ21", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body;GO:1990811 MWP complex", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0030030 cell projection organization;GO:1902857 positive regulation of non-motile cilium assembly;GO:1990810 microtubule anchoring at mitotic spindle pole body", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JM98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YS6-1", "uniprot_id": [ { "id": "AFAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YS6", "type": "external" } ], "mass": 80615.0, "length": 731, "protein_name": "Actin filament-associated protein 1", "gene_name": "Afap1", "organism": "Mouse", "refseq_name": "actin filament-associated protein 1 isoform 2", "refseq_ac": [ { "id": "NP_081649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081649", "type": "external" } ], "gene_names_uniprotkb": "Afap1; Kiaa3018", "gene_names_refseq": "2600003E23Rik; 9630044L16Rik; Afap1; Afap; mKIAA3018", "protein_names_uniprotkb": "Actin filament-associated protein 1; 110 kDa actin filament-associated protein; AFAP-110", "protein_names_refseq": "110 kDa actin filament-associated protein; AFAP-110; actin filament-associated protein 1 isoform 2", "tax_id": 10090, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067)", "pathway": " (mmu:70292)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12532398;15314167;17242355;17360811;19281763;21183079;21750661;25043309;25428506;30084848;34428180", "class_list": "glycogene", "function": "Actin filament associated protein-110 (AFAP) colocalizes with cSrc to promote cSrc activation and cell migration., [RefSeq, PubMed]; Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data suggest that one major function of AFAP-110 is to relay signals from protein kinase C alpha that direct the activation of c-Src and the formation of podosomes., [RefSeq, PubMed]; In E16 mouse embryos, AFAP expression levels concentrated in the olfactory bulb, cortex, forebrain, cerebellum, and various peripheral sensory structures.In P3 mouse pups, overall expression was reduced. (AFAP-110), [RefSeq, PubMed]; These data define, for the first time, the requirement of AFAP1 for the spatial and temporal regulation of cSrc activity in the normal breast, specifically for milk production., [RefSeq, PubMed]; These results indicate that AFAP120 plays a role in organizing dynamic actin structures during neuronal differentiation and suggest that AFAP120 may help regulate the transition from motile precursor to morphologically differentiated neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGX1;Q6ZPE4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0009966 regulation of signal transduction;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80YS6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48962-1", "uniprot_id": [ { "id": "ADT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48962", "type": "external" } ], "mass": 32904.0, "length": 298, "protein_name": "ADP/ATP translocase 1", "gene_name": "Slc25a4", "organism": "Mouse", "refseq_name": "ADP/ATP translocase 1", "refseq_ac": [ { "id": "NP_031476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031476", "type": "external" } ], "gene_names_uniprotkb": "Slc25a4; Aac1; Anc1; Ant1", "gene_names_refseq": "Ant1; Slc25a4; mANC1", "protein_names_uniprotkb": "ADP/ATP translocase 1; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ANT 1; Adenine nucleotide translocator 1; Solute carrier family 25 member 4", "protein_names_refseq": "ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle; ADP/ATP translocase 1; ANT 1; adenine nucleotide translocase-1; adenine nucleotide translocator 1, skeletal muscle; solute carrier family 25 member 4", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 12a (Disease Ontology:DOID:0080130); mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); Alzheimer's disease (Disease Ontology:DOID:10652); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); epilepsy (Disease Ontology:DOID:1826); mitochondrial myopathy (Disease Ontology:DOID:699); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:11739); (R-MMU-166187); (R-MMU-83936)", "pathway_count": 3, "publication_count": 32, "publication_id_list": "10974536;11809823;14749836;16303948;18034455;18250455;19644512;20671283;22645316;23806337;24788674;25428506;25605945;26495903;26740625;30084848;30779550;31341297;31489369;31618756;33300544;34428180;35820727;36288343;37377022;37462785;37507081;37828378;38654053;39927985;8903724;9207786", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:31341297, PubMed:31618756). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity) In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31341297, PubMed:31489369). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:31341297). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (PubMed:31341297). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:31341297). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (PubMed:31341297). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31489369). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (PubMed:31489369). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (PubMed:31618756)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation., [RefSeq, PubMed]; Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster. Publication Status: Online-Only, [RefSeq, PubMed]; The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62164", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005471 ATP:ADP antiporter activity;GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0046902 regulation of mitochondrial membrane permeability;GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development;GO:0008637 apoptotic mitochondrial changes;GO:0015866 ADP transport", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P48962-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60604-1", "uniprot_id": [ { "id": "SCIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60604", "type": "external" } ], "mass": 80254.0, "length": 715, "protein_name": "Scinderin", "gene_name": "Scin", "organism": "Mouse", "refseq_name": "scinderin isoform 1", "refseq_ac": [ { "id": "NP_001139668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139668", "type": "external" } ], "gene_names_uniprotkb": "Scin", "gene_names_refseq": "Scin; adseverin", "protein_names_uniprotkb": "Scinderin; Adseverin; Gelsolin-like protein", "protein_names_refseq": "gelsolin-like protein; scinderin isoform 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:20259)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11883943;17947660;25275604;25681458;28011936;37450577;37540756;37936437;9671468", "class_list": "", "function": "Adseverin induction is a specific gene regulatory effect by TCDD on thymocytes., [RefSeq, PubMed]; Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression., [RefSeq, PubMed]; Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)., [RefSeq, PubMed]; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:9671468). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:9671468). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (PubMed:25275604, PubMed:25681458). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner., [UniProtKB, PubMed]; Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08988;O08990;Q6P4N8", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0002102 podosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q60604-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08691-1", "uniprot_id": [ { "id": "ARGI2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08691", "type": "external" } ], "mass": 38878.0, "length": 354, "protein_name": "Arginase-2, mitochondrial", "gene_name": "Arg2", "organism": "Mouse", "refseq_name": "arginase-2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_033835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033835", "type": "external" } ], "gene_names_uniprotkb": "Arg2", "gene_names_refseq": "AII; Arg2", "protein_names_uniprotkb": "Arginase-2, mitochondrial; 3.5.3.1; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase", "protein_names_refseq": "arginase II; arginase-2, mitochondrial precursor; arginase-2, mitochondrial; kidney-type arginase; non-hepatic arginase; type II arginase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); hyperargininemia (Disease Ontology:DOID:9278)", "pathway": " (mmu:11847); (R-MMU-70635); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "22928666;25009204;25484082;27074721;27214549;27745970;30084848;39116884;9608538;9745037;9814991", "class_list": "", "function": "Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism., [RefSeq, PubMed]; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:25009204, PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (PubMed:27074721). May play a role in promoting prenatal immune suppression (By similarity). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.5.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.-", "type": "external" }, { "id": "3.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17", "type": "external" }, { "id": "3.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0050998 nitric-oxide synthase binding;GO:0004053 arginase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032700 negative regulation of interleukin-17 production;GO:0032651 regulation of interleukin-1 beta production;GO:0045087 innate immune response;GO:0032720 negative regulation of tumor necrosis factor production;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08691-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86044-1", "uniprot_id": [ { "id": "ANO9_MOUSE", "url": "https://www.uniprot.org/uniprot/P86044", "type": "external" } ], "mass": 87180.0, "length": 747, "protein_name": "Anoctamin-9", "gene_name": "Ano9", "organism": "Mouse", "refseq_name": "anoctamin-9", "refseq_ac": [ { "id": "NP_848468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848468", "type": "external" } ], "gene_names_uniprotkb": "Ano9; Tmem16j", "gene_names_refseq": "5430425C04Rik; Ano9; Tmem16j; Tp53i5; Trp53i5", "protein_names_uniprotkb": "Anoctamin-9; Transmembrane protein 16J", "protein_names_refseq": "Trp53 inducible protein 5; anoctamin-9; transformation related protein 53 inducible protein 5; transmembrane protein 16J; tumor protein p53 inducible protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:71345); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18729231;20056604;22302790;23532839;29604966;34428180;36330924;36520003", "class_list": "", "function": "ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function., [RefSeq, PubMed]; Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction., [RefSeq, PubMed]; PKA-activated nonselective cation channel (PubMed:29604966, PubMed:36330924). Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (PubMed:29604966). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store (By similarity). Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue (By similarity). Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (PubMed:36330924). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). Can inhibit the activity of ANO1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0005262 calcium channel activity;GO:0015267 channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:1902476 chloride transmembrane transport;GO:0007608 sensory perception of smell;GO:0061589 calcium activated phosphatidylserine scrambling;GO:0061590 calcium activated phosphatidylcholine scrambling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P86044-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97793-1", "uniprot_id": [ { "id": "ALK_MOUSE", "url": "https://www.uniprot.org/uniprot/P97793", "type": "external" } ], "mass": 174948.0, "length": 1621, "protein_name": "ALK tyrosine kinase receptor", "gene_name": "Alk", "organism": "Mouse", "refseq_name": "ALK tyrosine kinase receptor precursor", "refseq_ac": [ { "id": "NP_031465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031465", "type": "external" } ], "gene_names_uniprotkb": "Alk", "gene_names_refseq": "Alk; CD246; Tcrz", "protein_names_uniprotkb": "ALK tyrosine kinase receptor; 2.7.10.1; Anaplastic lymphoma kinase", "protein_names_refseq": "ALK tyrosine kinase receptor precursor; ALK tyrosine kinase receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cancer (Disease Ontology:DOID:162); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:11682); (R-MMU-201556); (R-MMU-9851151)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15226403;16458083;16878150;17487225;19200234;19459784;22079349;30497772;31599954;32442405;33479180;33877580;37291945;38000524;9053841", "class_list": "", "function": "LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity., [RefSeq, PubMed]; Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection., [RefSeq, PubMed]; Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:15226403, PubMed:16458083, PubMed:16878150, PubMed:19200234, PubMed:30497772). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (PubMed:32442405). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response. In contrast, ALKAL1 is not a potent physiological ligand for ALK. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (By similarity). May function as regulator of gastric epithelial differentiation (PubMed:33479180)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 11, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "E9QKV3", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0044297 cell body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0030534 adult behavior;GO:0038083 peptidyl-tyrosine autophosphorylation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P97793-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TSG4-1", "uniprot_id": [ { "id": "ALKB5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TSG4", "type": "external" } ], "mass": 44411.0, "length": 395, "protein_name": "RNA demethylase ALKBH5", "gene_name": "Alkbh5", "organism": "Mouse", "refseq_name": "RNA demethylase ALKBH5", "refseq_ac": [ { "id": "NP_766531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766531", "type": "external" } ], "gene_names_uniprotkb": "Alkbh5; Abh5; Ofoxd", "gene_names_refseq": "Abh5; Alkbh5; E130207K11; Ofoxd", "protein_names_uniprotkb": "RNA demethylase ALKBH5; 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "protein_names_refseq": "RNA demethylase ALKBH5; alkB, alkylation repair homolog 5; alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5", "tax_id": 10090, "disease": "", "pathway": " (mmu:268420); (R-MMU-73943)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;21183079;23177736;29279410;31219806;35939687;36859428;39441582", "class_list": "", "function": "ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation., [RefSeq, PubMed]; Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:29279410, PubMed:35939687, PubMed:36859428). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:35939687, PubMed:36859428). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (PubMed:23177736, PubMed:29279410). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (By similarity). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (By similarity). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (PubMed:35939687). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (PubMed:36859428)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80US0;Q8BKB9;Q8BKC1", "ec_number_list": [ { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0035515 oxidative RNA demethylase activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TSG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XC0-1", "uniprot_id": [ { "id": "AJUBA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XC0", "type": "external" } ], "mass": 57920.0, "length": 547, "protein_name": "LIM domain-containing protein ajuba", "gene_name": "Ajuba", "organism": "Mouse", "refseq_name": "LIM domain-containing protein ajuba", "refseq_ac": [ { "id": "NP_034720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034720", "type": "external" } ], "gene_names_uniprotkb": "Ajuba; Jub", "gene_names_refseq": "Ajuba; Jub", "protein_names_uniprotkb": "LIM domain-containing protein ajuba", "protein_names_refseq": "LIM domain-containing protein ajuba; protein ajuba", "tax_id": 10090, "disease": "", "pathway": " (mmu:16475); (R-MMU-1234176); (R-MMU-2565942)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10330178;11029037;15728191;15870270;15870274;17909014;18331720;31219806;34678516;34706234;35535434;36852467", "class_list": "", "function": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control., [RefSeq, PubMed]; Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues., [RefSeq, PubMed]; This paper presents evidence indicating that the human and mouse Ajuba is a new cytosolic component of the IL-1 signaling pathway, influencing the assembly and activity of the aPKC/p62/TRAF6 multiprotein signaling complex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97472", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0003714 transcription corepressor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0046474 glycerophospholipid biosynthetic process;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91XC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924C5-1", "uniprot_id": [ { "id": "ALPK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924C5", "type": "external" } ], "mass": 180115.0, "length": 1680, "protein_name": "Alpha-protein kinase 3", "gene_name": "Alpk3", "organism": "Mouse", "refseq_name": "alpha-protein kinase 3", "refseq_ac": [ { "id": "NP_473426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473426", "type": "external" } ], "gene_names_uniprotkb": "Alpk3; Kiaa1330", "gene_names_refseq": "Alpk3; D330016D04; MAK; Midori; mKIAA1330", "protein_names_uniprotkb": "Alpha-protein kinase 3; 2.7.11.1; Midori; Myocytic induction/differentiation originator", "protein_names_refseq": "alpha-protein kinase 3; myocyte induction differentiation originator; myocytic induction/differentiation originator", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 27 (Disease Ontology:DOID:0061102)", "pathway": " (mmu:116904)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11418590;21183079;21441111;36288343", "class_list": "", "function": "ALPK3 plays a role in establishing normal structure and function of the myocardium. GeneRIF: Cardiomyopathy developed in mice deficient for alpha-kinase 3 (ALPK3), [RefSeq, PubMed]; Involved in cardiomyocyte differentiation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3YUT2;Q5DTY6;Q8C7A3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007507 heart development;GO:0055007 cardiac muscle cell differentiation;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q924C5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R182-1", "uniprot_id": [ { "id": "ANGL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R182", "type": "external" } ], "mass": 52543.0, "length": 455, "protein_name": "Angiopoietin-related protein 3", "gene_name": "Angptl3", "organism": "Mouse", "refseq_name": "angiopoietin-related protein 3 preproprotein", "refseq_ac": [ { "id": "NP_038941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038941", "type": "external" } ], "gene_names_uniprotkb": "Angptl3", "gene_names_refseq": "Angptl3; hypl", "protein_names_uniprotkb": "Angiopoietin-related protein 3; Angiopoietin-like protein 3", "protein_names_refseq": "angiopoietin-like protein 3; angiopoietin-related protein 3 preproprotein; angiopoietin-related protein 3", "tax_id": 10090, "disease": "familial hypobetalipoproteinemia 2 (Disease Ontology:DOID:0111061)", "pathway": " (mmu:30924); (R-MMU-8963889)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10644446;11788823;11877390;12671033;12909640;15336575;15863837;16081640;16508209;17110602;17681148;20424482;20581395;20633534;20959605;23918928;24294595;25338813;25710887;25954050;26305978;30084848;34428180;34841293;37344779;37638046;38462608", "class_list": "", "function": "ANGPTL3 is a novel HDL component that regulates HDL function. Publication Status: Online-Only, [RefSeq, PubMed]; ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo, [RefSeq, PubMed]; Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12671033). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (PubMed:26305978). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity; the function seems to be specific for the feeding conditions. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12909640, PubMed:16081640, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids; the cleaved N-terminal domain is more efficient than the uncleaved proprotein (PubMed:17681148). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (By similarity). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (PubMed:26305978). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR (PubMed:25954050). May stimulate hypothalamic LPL activity (PubMed:25338813)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Involved in angiogenesis (PubMed:11877390). Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (By similarity). May increase the motility of podocytes. Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (By similarity). May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation (PubMed:20633534, PubMed:24294595, PubMed:25710887). Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (PubMed:20959605)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0055102 lipase inhibitor activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0001525 angiogenesis;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9R182-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1F4-1", "uniprot_id": [ { "id": "ARRD4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1F4", "type": "external" } ], "mass": 44970.0, "length": 415, "protein_name": "Arrestin domain-containing protein 4", "gene_name": "Arrdc4", "organism": "Mouse", "refseq_name": "arrestin domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001036057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036057", "type": "external" } ], "gene_names_uniprotkb": "Arrdc4", "gene_names_refseq": "2410003C09Rik; Arrdc4", "protein_names_uniprotkb": "Arrestin domain-containing protein 4", "protein_names_refseq": "arrestin domain-containing protein 4 isoform 1; arrestin domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:66412)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19605364;27462458;32152506;35950500;37451484;38528189;38946541", "class_list": "", "function": "An insulin-regulated arrestin domain protein controls hepatic glucagon action., [RefSeq, PubMed]; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:27462458). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). May play a role in glucose uptake (By similarity). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart., [RefSeq, PubMed]; Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes., [RefSeq, PubMed]; Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD69", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0016567 protein ubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0051443 positive regulation of ubiquitin-protein transferase activity;GO:0032728 positive regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0B4J1F4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64430-1", "uniprot_id": [ { "id": "ATP7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64430", "type": "external" } ], "mass": 161959.0, "length": 1491, "protein_name": "Copper-transporting ATPase 1", "gene_name": "Atp7a", "organism": "Mouse", "refseq_name": "copper-transporting ATPase 1 isoform 2", "refseq_ac": [ { "id": "NP_033856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033856", "type": "external" } ], "gene_names_uniprotkb": "Atp7a; Mnk", "gene_names_refseq": "Atp7a; MNK", "protein_names_uniprotkb": "Copper-transporting ATPase 1; 7.2.2.8; Copper pump 1; Menkes disease-associated protein homolog", "protein_names_refseq": "ATPase, Cu++ transporting, alpha polypeptide; Menkes protein; copper pump 1; copper-transporting ATPase 1 isoform 2; copper-transporting ATPase 1; menkes disease-associated protein homolog", "tax_id": 10090, "disease": "X-linked distal spinal muscular atrophy 3 (Disease Ontology:DOID:0111196); occipital horn syndrome (Disease Ontology:DOID:0111272); Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); spinal muscular atrophy (Disease Ontology:DOID:12377); Menkes disease (Disease Ontology:DOID:1838); cutis laxa (Disease Ontology:DOID:3144); aortic aneurysm (Disease Ontology:DOID:3627); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); osteoarthritis (Disease Ontology:DOID:8398); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); Wilson disease (Disease Ontology:DOID:893); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (mmu:11977); (R-MMU-6803544); (R-MMU-936837)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12488345;15634787;16371425;18650808;19144319;20173027;21183079;21750661;25639447;27337370;34035268;34428180;36232742;8054976;8054977;9215672;9385451", "class_list": "", "function": "ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:18650808, PubMed:25639447, PubMed:27337370). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:12488345, PubMed:16371425, PubMed:18650808, PubMed:27337370). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (By similarity). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (PubMed:12488345, PubMed:15634787, PubMed:16371425, PubMed:25639447). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (PubMed:18650808)., [UniProtKB, UniProtKB]; Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease. Publication Status: Online-Only, [RefSeq, PubMed]; The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AG69;O35101;P97422;Q64431", "ec_number_list": [ { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0031267 small GTPase binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0007626 locomotory behavior;GO:0030198 extracellular matrix organization;GO:0048286 lung alveolus development;GO:0001974 blood vessel remodeling", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q64430-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4N7-1", "uniprot_id": [ { "id": "ARI1B_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4N7", "type": "external" } ], "mass": 242882.0, "length": 2306, "protein_name": "AT-rich interactive domain-containing protein 1B", "gene_name": "Arid1b", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 1B isoform X1", "refseq_ac": [ { "id": "XP_006523284", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006523284", "type": "external" } ], "gene_names_uniprotkb": "Arid1b; Baf250b", "gene_names_refseq": "8030481M12; 9330189K18Rik; Ardi1b; Arid1b; B230217J03Rik; BAF250B; mKIAA1235", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 1B; ARID domain-containing protein 1B; BAF250B; BRG1-associated factor 250b", "protein_names_refseq": "AT-rich interactive domain-containing protein 1B isoform X1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Coffin-Siris syndrome 1 (Disease Ontology:DOID:0070042); Coffin-Siris syndrome 2 (Disease Ontology:DOID:0070044); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); ischemia (Disease Ontology:DOID:326); lung non-small cell carcinoma (Disease Ontology:DOID:3908); kidney disease (Disease Ontology:DOID:557); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:239985); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9934037)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "17640523;21183079;21750661;22645316;22952240;24129315;25428506;26601204;34678516;40885482;40997131", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Binds DNA non-specifically., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016514 SWI/SNF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0060996 dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "E9Q4N7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7D5-1", "uniprot_id": [ { "id": "ARHG5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7D5", "type": "external" } ], "mass": 176664.0, "length": 1581, "protein_name": "Rho guanine nucleotide exchange factor 5", "gene_name": "Arhgef5", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 5", "refseq_ac": [ { "id": "NP_598435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598435", "type": "external" } ], "gene_names_uniprotkb": "Arhgef5", "gene_names_refseq": "2210412D05Rik; Arhgef5; Tim1", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 5", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 5; rho guanine nucleotide exchange factor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:54324); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013408)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19713215;21183079;21525037;21750661;30059200;32782141;34418053;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:19713215, PubMed:21525037). Strongly activates RHOA (PubMed:19713215, PubMed:21525037). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (PubMed:19713215). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:21525037). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation (PubMed:21525037). Involved in positive regulation of immature dendritic cell migration (PubMed:19713215)., [UniProtKB, UniProtKB, PubMed, PubMed]; RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8R172;Q922T1", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity;GO:1904591 positive regulation of protein import;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9Q7D5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58242-1", "uniprot_id": [ { "id": "ASM3B_MOUSE", "url": "https://www.uniprot.org/uniprot/P58242", "type": "external" } ], "mass": 51600.0, "length": 456, "protein_name": "Acid sphingomyelinase-like phosphodiesterase 3b", "gene_name": "Smpdl3b", "organism": "Mouse", "refseq_name": "acid sphingomyelinase-like phosphodiesterase 3b precursor", "refseq_ac": [ { "id": "NP_598649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598649", "type": "external" } ], "gene_names_uniprotkb": "Smpdl3b; Asml3b", "gene_names_refseq": "1110054A24Rik; Asml3b; Smpdl3b", "protein_names_uniprotkb": "Acid sphingomyelinase-like phosphodiesterase 3b; 3.1.4.-; ASM-like phosphodiesterase 3b", "protein_names_refseq": "ASM-like phosphodiesterase 3b; acid sphingomyelinase-like phosphodiesterase 3b precursor; acid sphingomyelinase-like phosphodiesterase 3b", "tax_id": 10090, "disease": "", "pathway": " (mmu:100340)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19656770;24925721;26095358;27687724;27836988;30899004;31217420;31219806;33300544;34428180;35820727;36094323;38266744", "class_list": "", "function": "Although a potential substrate for SMPDL3B is sphingomyelin, we identify other possible substrates such as CDP-choline, ATP, and ADP., [RefSeq, PubMed]; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358). Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724)., [UniProtKB, PubMed, PubMed]; Our results identify the membrane-modulating enzyme SMPDL3B as a negative regulator of TLR signaling that functions at the interface of membrane biology and innate immunity., [RefSeq, PubMed]; SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its silencing aggravates diabetic retinopathy of db/db mice: Activation of NLRP3/NF-kappaB pathway., [RefSeq, PubMed]; SMPDL3b may be an important modulator of podocyte function by shifting suPAR-mediated podocyte injury from a migratory phenotype to an apoptotic phenotype and that it represents a novel therapeutic glomerular disease target, [RefSeq, PubMed]; SMPDL3b modulates radiation-induced DNA damage response in renal podocytes., [RefSeq, PubMed]; Study reports that Smpdl3b excess, as observed in podocytes in diabetic kidney disease, impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insulin receptor isoforms binding to caveolin-1 in the plasma membrane. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrate that radiation injury induces early cytoskeletal remodeling, down-regulation of SMPDL3b, and elevation of cellular ceramide levels. Overexpression of SMPDL3b and pretreatment with rituximab confer a radioprotective effect in cultured podocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050728 negative regulation of inflammatory response;GO:0034122 negative regulation of toll-like receptor signaling pathway;GO:0006685 sphingomyelin catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P58242-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02067-1", "uniprot_id": [ { "id": "ASCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02067", "type": "external" } ], "mass": 24741.0, "length": 231, "protein_name": "Achaete-scute homolog 1", "gene_name": "Ascl1", "organism": "Mouse", "refseq_name": "achaete-scute homolog 1", "refseq_ac": [ { "id": "NP_032579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032579", "type": "external" } ], "gene_names_uniprotkb": "Ascl1; Ash1; Mash-1; Mash1", "gene_names_refseq": "ASH1; Ascl1; Mash1; bHLHa46", "protein_names_uniprotkb": "Achaete-scute homolog 1; ASH-1; mASH-1; mASH1", "protein_names_refseq": "achaete-scute complex homolog-like 1; achaete-scute complex-like protein 1; achaete-scute homolog 1; mammalian achaete scute homolog 1", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:17172)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1576967;16020526;17728344;18173746;20107439;23576753;24243019;27281220;8217843;8221886;8424959", "class_list": "", "function": "Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNT5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043025 neuronal cell body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0048484 enteric nervous system development;GO:0048486 parasympathetic nervous system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q02067-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06507-1", "uniprot_id": [ { "id": "ATF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06507", "type": "external" } ], "mass": 38355.0, "length": 349, "protein_name": "Cyclic AMP-dependent transcription factor ATF-4", "gene_name": "Atf4", "organism": "Mouse", "refseq_name": "cyclic AMP-dependent transcription factor ATF-4", "refseq_ac": [ { "id": "NP_001274109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274109", "type": "external" } ], "gene_names_uniprotkb": "Atf4; Creb2", "gene_names_refseq": "Atf-4; Atf4; C/ATF; CREB-2; CREB2; TAXREB67", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-4; Activating transcription factor 4; C/ATF; C/EBP-related ATF; CREB-2; Cyclic AMP-responsive element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2", "protein_names_refseq": "c/EBP-related ATF; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67 homolog; taxREB67 homolog", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); borna disease (Disease Ontology:DOID:5154); pulmonary venoocclusive disease (Disease Ontology:DOID:5453)", "pathway": " (mmu:11911)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10096021;10885750;11018027;11106749;11806972;12667446;12925279;15109498;15277680;15775988;15911876;1631061;16751105;17369260;19232401;21159964;21203563;21750661;21768648;22298775;22572884;22974638;23624402;23663782;24008080;24809345;30209133;31023583;31219806;31444471;38192280;8506317", "class_list": "", "function": "Delayed reinitiation allows for ribosomes to scan through the inhibitory uORF2 and instead reinitiate at the ATF4-coding region., [RefSeq, PubMed]; Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:11106749, PubMed:12667446, PubMed:23624402, PubMed:8506317). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (PubMed:23624402, PubMed:8506317). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:11106749, PubMed:12667446). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:11106749, PubMed:12667446). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (PubMed:12667446). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (By similarity). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:15775988, PubMed:21159964). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (By similarity). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (PubMed:23624402). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (PubMed:31023583). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988, PubMed:17369260, PubMed:21159964). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (By similarity). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (PubMed:10096021, PubMed:10885750, PubMed:11806972, PubMed:12925279, PubMed:15109498, PubMed:22298775). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (PubMed:22298775). Activates transcription of SIRT4 (PubMed:23663782). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (PubMed:21768648, PubMed:22572884). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (PubMed:21768648, PubMed:22572884). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (PubMed:12925279). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4B2;Q61906", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0070982 L-asparagine metabolic process;GO:0035162 embryonic hemopoiesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q06507-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09PK2-1", "uniprot_id": [ { "id": "APRV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09PK2", "type": "external" } ], "mass": 37174.0, "length": 339, "protein_name": "Retroviral-like aspartic protease 1", "gene_name": "Asprv1", "organism": "Mouse", "refseq_name": "retroviral-like aspartic protease 1", "refseq_ac": [ { "id": "NP_080690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080690", "type": "external" } ], "gene_names_uniprotkb": "Asprv1; Sasp; Taps", "gene_names_refseq": "2300003P22Rik; Asprv1; SASPase; SASP; Taps", "protein_names_uniprotkb": "Retroviral-like aspartic protease 1; 3.4.23.-; SASPase; Skin aspartic protease; Skin-specific retroviral-like aspartic protease; TPA-inducible aspartic proteinase-like protein", "protein_names_refseq": "TPA-inducible aspartic proteinase-like protein; retroviral-like aspartic protease 1; skin aspartic protease; skin-specific retroviral-like aspartic protease", "tax_id": 10090, "disease": "", "pathway": " (mmu:67855)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16565508;16837463;20237492;21750661;34428180", "class_list": "", "function": "Aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia, [RefSeq, PubMed]; Detection of Taps levels represents a novel strategy to discriminate the progression state of squamous skin cancers., [RefSeq, PubMed]; Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The retroviral-like aspartic protease, SASPase, is involved in prevention of fine wrinkle formation via activation in a weakly acidic stratum corneum environment, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEV3;Q32P05;Q6PEP7;Q9D135", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016485 protein processing;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q09PK2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EBP3-1", "uniprot_id": [ { "id": "ARMC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5EBP3", "type": "external" } ], "mass": 96728.0, "length": 926, "protein_name": "Armadillo repeat-containing protein 5", "gene_name": "Armc5", "organism": "Mouse", "refseq_name": "armadillo repeat-containing protein 5", "refseq_ac": [ { "id": "NP_666317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666317", "type": "external" } ], "gene_names_uniprotkb": "Armc5", "gene_names_refseq": "Armc5", "protein_names_uniprotkb": "Armadillo repeat-containing protein 5", "protein_names_refseq": "armadillo repeat-containing protein 5", "tax_id": 10090, "disease": "ACTH-independent macronodular adrenal hyperplasia 2 (Disease Ontology:DOID:0111624)", "pathway": " (mmu:233912)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;28169274;28911199;35687106;38225631;39491648", "class_list": "", "function": "ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans. Publication Status: Online-Only, [RefSeq, PubMed]; New mouse line can be used to study tissue-specific effects of Armc5. Armc5 haploinsufficiency leads to Cushing syndrome in mice, but only later in life, and this involves PKA, its catalytic subunit Calpha, and the Wnt/beta-catenin pathway., [RefSeq, PubMed]; Study on Armc5 knockout mice revealed that ARMC5 is crucial in fetal development and immune responses. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (By similarity). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (By similarity). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (By similarity). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:39491648). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:28169274). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAU6;Q8CDI5;Q8R3J0", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0001701 in utero embryonic development;GO:0051607 defense response to virus;GO:0006633 fatty acid biosynthetic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5EBP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A058-1", "uniprot_id": [ { "id": "ARMX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A058", "type": "external" } ], "mass": 81036.0, "length": 784, "protein_name": "Armadillo repeat-containing X-linked protein 2", "gene_name": "Armcx2", "organism": "Mouse", "refseq_name": "armadillo repeat-containing X-linked protein 2", "refseq_ac": [ { "id": "NP_001159869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159869", "type": "external" } ], "gene_names_uniprotkb": "Armcx2; Kiaa0512", "gene_names_refseq": "3230401N03Rik; ALEX2; Armcx2", "protein_names_uniprotkb": "Armadillo repeat-containing X-linked protein 2", "protein_names_refseq": "armadillo repeat-containing X-linked protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67416)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15759267;22517741;22569362;22645316;30084848;30779550;31219806;31599954;32848054;34428180;34678516;35822049;36852467;40021952;40885482", "class_list": "", "function": "Has a role in specification or development of the interstitial cell lineage in the developing testis, [RefSeq, PubMed]; May regulate the dynamics and distribution of mitochondria in neural cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AKS5;Q9CXI9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6A058-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VUP9-1", "uniprot_id": [ { "id": "AP2E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VUP9", "type": "external" } ], "mass": 46283.0, "length": 442, "protein_name": "Transcription factor AP-2-epsilon", "gene_name": "Tfap2e", "organism": "Mouse", "refseq_name": "transcription factor AP-2-epsilon", "refseq_ac": [ { "id": "NP_945198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_945198", "type": "external" } ], "gene_names_uniprotkb": "Tfap2e; Tcfap2e", "gene_names_refseq": "AP-2e; Tcfap2e; Tfap2e", "protein_names_uniprotkb": "Transcription factor AP-2-epsilon; AP2-epsilon; Activating enhancer-binding protein 2-epsilon", "protein_names_refseq": "AP2-epsilon; activating enhancer-binding protein 2-epsilon; transcription factor AP-2-epsilon", "tax_id": 10090, "disease": "sleep disorder (Disease Ontology:DOID:535)", "pathway": " (mmu:332937); (R-MMU-8866904); (R-MMU-8866907)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14572467;14636996;15305293;16684505;25428506;38773108", "class_list": "", "function": "AP-2 epsilon is important for the development of the olfactory system., [RefSeq, PubMed]; Cloning and characterization; AP-2 epsilon is expressed most prominently in the mitral cell layer of the developing olfactory bulb; it is able to activate transcription in a binding site-dependent manner, [RefSeq, PubMed]; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation., [UniProtKB, PubMed, PubMed, PubMed]; Transcription factor activating enhancer-binding protein 2epsilon (AP2epsilon) modulates phenotypic plasticity and progression of malignant melanoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A883", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6VUP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C142-1", "uniprot_id": [ { "id": "ARH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C142", "type": "external" } ], "mass": 33975.0, "length": 308, "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "Ldlrap1", "organism": "Mouse", "refseq_name": "low density lipoprotein receptor adapter protein 1", "refseq_ac": [ { "id": "NP_663529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663529", "type": "external" } ], "gene_names_uniprotkb": "Ldlrap1; Arh", "gene_names_refseq": "ARH2; Arh1; Arh; FHCB1; FHCB2; Ldlrap1", "protein_names_uniprotkb": "Low density lipoprotein receptor adapter protein 1; Autosomal recessive hypercholesterolemia protein homolog", "protein_names_refseq": "LDL receptor adaptor protein; autosomal recessive hypercholesterolemia protein homolog; low density lipoprotein receptor adapter protein 1", "tax_id": 10090, "disease": "autosomal recessive hypercholesterolemia (Disease Ontology:DOID:0090105)", "pathway": " (mmu:100017); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8964026); (R-MMU-8964038); (R-MMU-9758890)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12746448;15166224;15472122;21183079;27005486;30084848", "class_list": "", "function": "Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR is not cell-specific, but rather may depend on the cellular environment., [RefSeq, PubMed]; Results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor endocytosis in the liver, [RefSeq, PubMed]; The combination of Arh and Dab2 is responsible for the majority of adaptor function in LDLR endocytosis and LDLR-mediated cholesterol homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW86;Q6NWV6;Q8VDQ0", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005102 signaling receptor binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0030424 axon;GO:0055037 recycling endosome", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0031623 receptor internalization;GO:0042632 cholesterol homeostasis;GO:0042982 amyloid precursor protein metabolic process;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C142-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG76-1", "uniprot_id": [ { "id": "ARK72_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG76", "type": "external" } ], "mass": 40612.0, "length": 367, "protein_name": "Aflatoxin B1 aldehyde reductase member 2", "gene_name": "Akr7a2", "organism": "Mouse", "refseq_name": "aflatoxin B1 aldehyde reductase member 2", "refseq_ac": [ { "id": "NP_079613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079613", "type": "external" } ], "gene_names_uniprotkb": "Akr7a2; Afar; Akr7a5", "gene_names_refseq": "0610025K21Rik; Afar1; Afar; Akr7a2; Akr7a5", "protein_names_uniprotkb": "Aflatoxin B1 aldehyde reductase member 2; 1.1.1.n11; SSA reductase; Succinic semialdehyde reductase", "protein_names_refseq": "SSA reductase; aflatoxin B1 aldehyde reductase member 2; aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase); succinic semialdehyde reductase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (mmu:110198); (R-MMU-5423646)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12071861;12123834;12879023;16460003;17242355;21183079;22863590;23576753;23806337;24590062;31219806;34428180;37507081;39365156", "class_list": "", "function": "AKR7A5 has selective substrate specificity towards naphthoquinone derivatives, suggesting that the aldo-keto reductase could play an important role in metabolism of certain naphthoquinone derivatives., [RefSeq, PubMed]; AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice., [RefSeq, PubMed]; Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity)., [UniProtKB, PubMed]; These findings indicate the importance of AKR7A5 in protecting cells from the damaging effects of oxidative stress, and that this cytoprotective function is carried out through multiple pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMV3;Q3UPU2;Q8CG77;Q8JZQ8;Q9D157", "ec_number_list": [ { "id": "1.1.1.n11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n11", "type": "external" } ], "go_molecular_function": "GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005790 smooth endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CG76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ27-1", "uniprot_id": [ { "id": "ASPM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ27", "type": "external" } ], "mass": 364218.0, "length": 3122, "protein_name": "Abnormal spindle-like microcephaly-associated protein homolog", "gene_name": "Aspm", "organism": "Mouse", "refseq_name": "abnormal spindle-like microcephaly-associated protein homolog", "refseq_ac": [ { "id": "NP_033921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033921", "type": "external" } ], "gene_names_uniprotkb": "Aspm; Calmbp1; Sha1", "gene_names_refseq": "Aspm; Calmbp1; D330028K02Rik; MCPH5; Sha1", "protein_names_uniprotkb": "Abnormal spindle-like microcephaly-associated protein homolog; Calmodulin-binding protein 1; Calmodulin-binding protein Sha1; Spindle and hydroxyurea checkpoint abnormal protein", "protein_names_refseq": "abnormal spindle-like microcephaly-associated protein homolog; asp (abnormal spindle)-like, microcephaly associated; calmodulin-binding protein 1; calmodulin-binding protein Sha1; spindle and hydroxyurea checkpoint abnormal protein", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 5 (Disease Ontology:DOID:0070280); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); stomach cancer (Disease Ontology:DOID:10534); microcephaly (Disease Ontology:DOID:10907); ovary epithelial cancer (Disease Ontology:DOID:2152); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12316)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12351193;12355089;15972725;16479539;22872234;25428506;25605945;28436967;30084848;31219806;34203471;34428180;36980263;38019816;9819352", "class_list": "", "function": "Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis., [UniProtKB, PubMed, PubMed, PubMed]; Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Tissue distribution of Calmbp1 in fetal and adult mice, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JES1;B1ARM7;O88482;Q4G1G9;Q8BJI8;Q8BKT4", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "GO:0007283 spermatogenesis;GO:0045665 negative regulation of neuron differentiation;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CJ27-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3A6-1", "uniprot_id": [ { "id": "ARMX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3A6", "type": "external" } ], "mass": 33321.0, "length": 301, "protein_name": "Protein ARMCX6", "gene_name": "Armcx6", "organism": "Mouse", "refseq_name": "protein ARMCX6", "refseq_ac": [ { "id": "NP_001007579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007579", "type": "external" } ], "gene_names_uniprotkb": "Armcx6", "gene_names_refseq": "Armcx6", "protein_names_uniprotkb": "Protein ARMCX6", "protein_names_refseq": "protein ARMCX6", "tax_id": 10090, "disease": "", "pathway": " (mmu:278097)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22569362;25428506;30084848;34428180", "class_list": "", "function": "May regulate the dynamics and distribution of mitochondria in neural cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKS3;Q3TUH4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K3A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQY1-1", "uniprot_id": [ { "id": "ATG12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQY1", "type": "external" } ], "mass": 15207.0, "length": 141, "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "Atg12", "organism": "Mouse", "refseq_name": "ubiquitin-like protein ATG12", "refseq_ac": [ { "id": "NP_080493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080493", "type": "external" } ], "gene_names_uniprotkb": "Atg12; Apg12l; Apg12", "gene_names_refseq": "4931423H11Rik; A330058M13Rik; Apg12l; Atg12l; Atg12", "protein_names_uniprotkb": "Ubiquitin-like protein ATG12; APG12-like; Autophagy-related protein 12", "protein_names_refseq": "autophagy-related protein 12; ubiquitin-like protein ATG12", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)", "pathway": " (mmu:67526); (R-MMU-1632852); (R-MMU-5205685); (R-MMU-8934903)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11266458;12482611;12665549;12890687;17709747;18704115;18768753;19417210;20723759;22082872;25686249;38227290", "class_list": "", "function": "(Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection., [UniProtKB, PubMed]; Overexpression of Atg5 or Atg12 resulted in Atg5-Atg12 conjugate formation and suppression of RNA-mediated signaling., [RefSeq, PubMed]; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (PubMed:38227290)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKE5;Q9D7Y5", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1904973 positive regulation of viral translation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CQY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7A8-1", "uniprot_id": [ { "id": "ARMC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7A8", "type": "external" } ], "mass": 31247.0, "length": 282, "protein_name": "Armadillo repeat-containing protein 1", "gene_name": "Armc1", "organism": "Mouse", "refseq_name": "armadillo repeat-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_083116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083116", "type": "external" } ], "gene_names_uniprotkb": "Armc1", "gene_names_refseq": "2310016N05Rik; 2900046P06Rik; 3110009G21Rik; Arcp; Armc1; C330014L16Rik", "protein_names_uniprotkb": "Armadillo repeat-containing protein 1", "protein_names_refseq": "armadillo repeat containing protein; armadillo repeat-containing protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74252)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16452087;21183079;36288343", "class_list": "", "function": "In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBW1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0048312 intracellular distribution of mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D7A8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35569-1", "uniprot_id": [ { "id": "IRS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35569", "type": "external" } ], "mass": 130723.0, "length": 1233, "protein_name": "Insulin receptor substrate 1", "gene_name": "Irs1", "organism": "Mouse", "refseq_name": "insulin receptor substrate 1", "refseq_ac": [ { "id": "NP_034700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034700", "type": "external" } ], "gene_names_uniprotkb": "Irs1; Irs-1", "gene_names_refseq": "G972R; IRS-1; Irs1", "protein_names_uniprotkb": "Insulin receptor substrate 1; IRS-1", "protein_names_refseq": "insulin receptor substrate 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); osteoporosis (Disease Ontology:DOID:11476); uterine fibroid (Disease Ontology:DOID:13223); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16367); (R-MMU-109704); (R-MMU-112399); (R-MMU-112412); (R-MMU-1257604); (R-MMU-1266695); (R-MMU-198203); (R-MMU-201556); (R-MMU-2428928); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-74713); (R-MMU-74749); (R-MMU-9842663)", "pathway_count": 14, "publication_count": 141, "publication_id_list": "10.1101/2023.09.13.557529;10749573;11006284;11018022;11598104;11959983;12417588;12714600;12917346;14579029;14998989;15143153;15197263;15306821;15314024;15316008;15364919;15821749;15849359;15925330;15982669;16055440;16098829;16469808;16777975;16998818;17242355;17575262;17709744;18036196;18288188;18296638;18430969;18498745;18721257;18796617;19234595;19276091;19546233;19564410;19587264;19675138;20018868;20185762;20388826;20587749;20813836;20921627;21183079;21386087;21447485;21731668;21756814;22191431;22289908;22307032;22418434;22454293;22733784;22828956;22832498;22906703;22942720;22948222;23142081;23301857;23667647;24002347;24159000;24187137;24333417;24435134;24763529;24855642;24966659;25141786;25381390;25428506;25586176;25594850;25689493;25826740;26023930;26112408;26400768;26450947;26454089;26474286;26491103;26512886;26666849;26720454;26836389;26882989;27702567;27739494;27819676;27872488;28708100;28866332;28867797;28919555;29339083;29364220;29433422;29440699;29490521;29496905;29497383;29736736;29988567;30023489;30030460;30031227;30050584;30084848;30324688;30972066;31233775;31599954;31616027;32664532;32692982;32703455;32714408;32782141;32921413;32998286;33011364;33062046;33303821;34428180;35111058;35508278;35739993;35842638;35940125;38505620;7526222;8167159;8448209", "class_list": "", "function": "Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H[+]-ATPase V0d1 subunit. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:7526222). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (By similarity). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation (By similarity). Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010631 epithelial cell migration;GO:0030335 positive regulation of cell migration;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 14.9, "record_id": "P35569-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDF7-1", "uniprot_id": [ { "id": "EXD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDF7", "type": "external" } ], "mass": 63962.0, "length": 570, "protein_name": "piRNA biogenesis protein EXD1", "gene_name": "Exd1", "organism": "Mouse", "refseq_name": "piRNA biogenesis protein EXD1", "refseq_ac": [ { "id": "NP_766445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766445", "type": "external" } ], "gene_names_uniprotkb": "Exd1; Exdl1", "gene_names_refseq": "4932702D22Rik; Exd1; Exdl1; mExd1", "protein_names_uniprotkb": "piRNA biogenesis protein EXD1; Exonuclease 3'-5' domain-containing protein 1; Exonuclease 3'-5' domain-like-containing protein 1; Inactive exonuclease EXD1; mExd1", "protein_names_refseq": "Vexonuclease 3'-5' domain-like 1; exonuclease 3'-5' domain-containing protein 1; exonuclease 3'-5' domain-like 1; exonuclease 3'-5' domain-like-containing protein 1; inactive exonuclease EXD1; piRNA biogenesis protein EXD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241624)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;26669262;30257204;36624638", "class_list": "", "function": "EXD1 enhances MIWI2 piRNA biogenesis via a functional interaction with TDRD12., [RefSeq, PubMed]; Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes., [RefSeq, PubMed]; PiRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm., [RefSeq, PubMed]; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (PubMed:26669262). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:1990923 PET complex;GO:0043186 P granule", "go_biological_process": "GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CDF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R059-1", "uniprot_id": [ { "id": "FHL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R059", "type": "external" } ], "mass": 31795.0, "length": 289, "protein_name": "Four and a half LIM domains protein 3", "gene_name": "Fhl3", "organism": "Mouse", "refseq_name": "four and a half LIM domains protein 3", "refseq_ac": [ { "id": "NP_034343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034343", "type": "external" } ], "gene_names_uniprotkb": "Fhl3", "gene_names_refseq": "Fhl3; SLIM2", "protein_names_uniprotkb": "Four and a half LIM domains protein 3; FHL-3; SLIM-2; Skeletal muscle LIM-protein 2", "protein_names_refseq": "four and a half LIM domains protein 3; skeletal muscle LIM-protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14201)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10049693;10906474;12704194;15117962;17363903;21750661;23806337;26499038;39927985", "class_list": "", "function": "Actin was identified as a FHL3 binding partner; FHL3 is a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts., [RefSeq, PubMed]; FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells, [RefSeq, PubMed]; Four and a half LIM domain protein 3 could interact with MyoD, cyclic AMP-responsive elements and phosphorylated cAMP response element binding protein in vivo, [RefSeq, PubMed]; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6N4;Q9JLP5;Q9WUH3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R059-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70451-1", "uniprot_id": [ { "id": "FER_MOUSE", "url": "https://www.uniprot.org/uniprot/P70451", "type": "external" } ], "mass": 94579.0, "length": 823, "protein_name": "Tyrosine-protein kinase Fer", "gene_name": "Fer", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Fer isoform a", "refseq_ac": [ { "id": "NP_001033086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033086", "type": "external" } ], "gene_names_uniprotkb": "Fer; Fert2", "gene_names_refseq": "C330004K01Rik; Fert2; Fert; Fer", "protein_names_uniprotkb": "Tyrosine-protein kinase Fer; 2.7.10.2; Proto-oncogene c-Fer; p94-Fer", "protein_names_refseq": "fer (fms/fps related) protein kinase, testis specific 2; p94-Fer; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer; tyrosine-protein kinase Fer isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:14158); (R-MMU-1433557)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10074905;10391941;10878010;11006284;11134346;11339827;11994443;12200133;12738762;12901971;15226396;15467733;16176974;16731527;16732323;17606629;17947660;19131326;19159681;20133938;21750661;2294399;27226326;27401557;31219806;34428180;36620935;7623846;9742951", "class_list": "", "function": "Levels of FER were elevated in ovarian cancer cell lines relative to those in immortalized normal surface epithelial cells and that suppression of FER attenuated the motility and invasive properties of these cancer cells, [RefSeq, PubMed]; SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells., [RefSeq, PubMed]; Sperm from mice targeted with a kinase-inactivating mutation in Fer failed to undergo capacitation-associated increases in tyrosine phosphorylation., [RefSeq, PubMed]; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:10878010 and PubMed:19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61561;Q6PEE5;Q80UI3;Q8C481;Q9EQ77", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0006468 protein phosphorylation;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P70451-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97447-1", "uniprot_id": [ { "id": "FHL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97447", "type": "external" } ], "mass": 31889.0, "length": 280, "protein_name": "Four and a half LIM domains protein 1", "gene_name": "Fhl1", "organism": "Mouse", "refseq_name": "four and a half LIM domains protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001070830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070830", "type": "external" } ], "gene_names_uniprotkb": "Fhl1", "gene_names_refseq": "FHL-1; Fhl1; KyoT; RAM14-1; SLIM-1; SLIM", "protein_names_uniprotkb": "Four and a half LIM domains protein 1; FHL-1; KyoT; RAM14-1; RBP-associated molecule 14-1; SLIM-1; SLIM; Skeletal muscle LIM-protein 1", "protein_names_refseq": "RBP-associated molecule 14-1; four and a half LIM domains protein 1 isoform 2; four and a half LIM domains protein 1; skeletal muscle LIM-protein 1", "tax_id": 10090, "disease": "scapuloperoneal myopathy (Disease Ontology:DOID:0060253); X-linked Emery-Dreifuss muscular dystrophy 6 (Disease Ontology:DOID:0070251); reducing body myopathy 1A (Disease Ontology:DOID:0080090); reducing body myopathy 1B (Disease Ontology:DOID:0080687); Uruguay faciocardiomusculoskeletal syndrome (Disease Ontology:DOID:0112148); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:14199)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10049693;10906474;21750661;23806337;37507081;37884534;39927985;9418910", "class_list": "", "function": "FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design. Publication Status: Online-Only, [RefSeq, PubMed]; May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55181;Q8K318", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding;GO:0099104 potassium channel activator activity;GO:0099103 channel activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0030308 negative regulation of cell growth;GO:1901381 positive regulation of potassium ion transmembrane transport;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97447-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97480-1", "uniprot_id": [ { "id": "EYA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P97480", "type": "external" } ], "mass": 55973.0, "length": 510, "protein_name": "Protein phosphatase EYA3", "gene_name": "Eya3", "organism": "Mouse", "refseq_name": "protein phosphatase EYA3 isoform 2", "refseq_ac": [ { "id": "NP_034296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034296", "type": "external" } ], "gene_names_uniprotkb": "Eya3", "gene_names_refseq": "Eya3", "protein_names_uniprotkb": "Protein phosphatase EYA3; 3.1.3.48; Eyes absent homolog 3", "protein_names_refseq": "eyes absent 3 homolog; eyes absent homolog 3; protein phosphatase EYA3 isoform 2; protein phosphatase EYA3", "tax_id": 10090, "disease": "branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614)", "pathway": " (mmu:14050); (R-MMU-5693565)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10490620;12215533;14628042;14628052;14628053;17242355;18299400;21129973;21750661;21821028;21952136;25428506;25605945;30084848;30779550;31219806;31515519;9006082;9049631;9887327", "class_list": "", "function": "Data demonstrate that Eya3 and its partner Six1 synergistically activate TSHbeta expression and that this activation is further enhanced by Tef and Hlf., [RefSeq, PubMed]; Data showed that the 68-amino acid domain between positions 53 and 120 was necessary and sufficient for its threonine-phosphatase activity., [RefSeq, PubMed]; These observations establish EYA3 as a disease-modifying target whose function in the pathophysiology of pulmonary arterial hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. The phosphatase activity has been shown in vitro. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. May play a role in mediating the induction and differentiation of cranial placodes., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E8I5;P97768", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0140793 histone H2AXY142 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P97480-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61160-1", "uniprot_id": [ { "id": "FADD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61160", "type": "external" } ], "mass": 22960.0, "length": 205, "protein_name": "FAS-associated death domain protein", "gene_name": "Fadd", "organism": "Mouse", "refseq_name": "FAS-associated death domain protein", "refseq_ac": [ { "id": "NP_034305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034305", "type": "external" } ], "gene_names_uniprotkb": "Fadd; Mort1", "gene_names_refseq": "Fadd; Mort1/FADD", "protein_names_uniprotkb": "FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity", "protein_names_refseq": "FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas (TNFRSF6)-associated via death domain; Fas-associating protein with death domain; mediator of receptor induced toxicity; protein FADD", "tax_id": 10090, "disease": "brain glioma (Disease Ontology:DOID:0060108); immunodeficiency 90 (Disease Ontology:DOID:0061060); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prostatic hypertrophy (Disease Ontology:DOID:11132); leukemia (Disease Ontology:DOID:1240); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14082); (R-MMU-140534); (R-MMU-2562578); (R-MMU-3371378); (R-MMU-5218900); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5675482); (R-MMU-69416); (R-MMU-75157); (R-MMU-75158)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "10347191;12705854;15383280;17030115;21183079;24548998;26495903;28842570;29440439;30185824;31519887;34471287;8565075;8649383", "class_list": "", "function": "Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC37;Q61082", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61160-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6L0-1", "uniprot_id": [ { "id": "FIL1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P6L0", "type": "external" } ], "mass": 129772.0, "length": 1131, "protein_name": "Filamin A-interacting protein 1-like", "gene_name": "Filip1l", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Filip1l; Doc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Filamin A-interacting protein 1-like; DOC-1; Protein down-regulated in ovarian cancer 1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:78749)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;19131326;21183079;21750661;32782141;34418053;34428180", "class_list": "", "function": "Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2ZAA3;B3GM33;Q05CK4;Q3UIY5;Q4G0B9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:1903119 protein localization to actin cytoskeleton;GO:0061525 hindgut development;GO:0008104 intracellular protein localization;GO:0009306 protein secretion;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P6L0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXW2-1", "uniprot_id": [ { "id": "FBXW5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXW2", "type": "external" } ], "mass": 64646.0, "length": 573, "protein_name": "F-box/WD repeat-containing protein 5", "gene_name": "Fbxw5", "organism": "Mouse", "refseq_name": "F-box/WD repeat-containing protein 5 isoform 1", "refseq_ac": [ { "id": "NP_038936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038936", "type": "external" } ], "gene_names_uniprotkb": "Fbxw5; Fbw5", "gene_names_refseq": "Fbw5; Fbxw5", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5", "protein_names_refseq": "F-box and WD-40 domain-containing protein 5; F-box protein Fbw5; F-box/WD repeat-containing protein 5 isoform 1; F-box/WD repeat-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:30839); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10531037;21750661;23314863;24444419;25605945;30703849;32971071", "class_list": "", "function": "FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway., [RefSeq, PubMed]; FBXW5 facilitated the addition of Lys63-linked ubiquitin to ASK1 and thus exacerbated ASK1-c-Jun N-terminal kinase/p38 MAPK signaling, inflammation, and lipid accumulation., [RefSeq, PubMed]; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ36;A2AJ37;E9QMP0;Q3U368", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0007088 regulation of mitotic nuclear division;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QXW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ULZ2-1", "uniprot_id": [ { "id": "FHDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ULZ2", "type": "external" } ], "mass": 125367.0, "length": 1149, "protein_name": "FH2 domain-containing protein 1", "gene_name": "Fhdc1", "organism": "Mouse", "refseq_name": "FH2 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001028473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028473", "type": "external" } ], "gene_names_uniprotkb": "Fhdc1; Inf1; Kiaa1727", "gene_names_refseq": "6330505N24Rik; Fhdc1; Gm126", "protein_names_uniprotkb": "FH2 domain-containing protein 1; Inverted formin-1", "protein_names_refseq": "FH2 domain-containing protein 1; inverted formin-1", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease dominant intermediate E (Disease Ontology:DOID:0110205)", "pathway": " (mmu:229474)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18815276;21183079;21750661;26564798;29742020", "class_list": "", "function": "FHDC1 plays a role in coordinating cytoskeletal dynamics during normal cilia assembly., [RefSeq, PubMed]; Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EHC4;Q69ZC2;Q8C0A0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005884 actin filament;GO:0005929 cilium;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0060271 cilium assembly;GO:0030041 actin filament polymerization;GO:0090161 Golgi ribbon formation;GO:0043149 stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3ULZ2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDC1-1", "uniprot_id": [ { "id": "FYCO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDC1", "type": "external" } ], "mass": 162336.0, "length": 1437, "protein_name": "FYVE and coiled-coil domain-containing protein 1", "gene_name": "Fyco1", "organism": "Mouse", "refseq_name": "FYVE and coiled-coil domain-containing protein 1", "refseq_ac": [ { "id": "NP_001103723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103723", "type": "external" } ], "gene_names_uniprotkb": "Fyco1", "gene_names_refseq": "2810409M01Rik; Fyco1; Mem2; RUFY3; ZFYVE7", "protein_names_uniprotkb": "FYVE and coiled-coil domain-containing protein 1", "protein_names_refseq": "FYVE and coiled-coil domain-containing protein 1; maternal embryonic message 2", "tax_id": 10090, "disease": "cataract 18 (Disease Ontology:DOID:0110238)", "pathway": " (mmu:17281)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12461651;17242355;19144319;21183079;21636066;21750661;34215815;34418053;34428180;35343376", "class_list": "", "function": "Loss of FYCO1 leads to cataract formation. Publication Status: Online-Only, [RefSeq, PubMed]; May mediate microtubule plus end-directed vesicle transport., [UniProtKB]; The role of FYCO1-dependent autophagy in lens fiber cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V385;Q7TMT0;Q8BJN2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005770 late endosome;GO:0005776 autophagosome", "go_biological_process": "GO:1901098 positive regulation of autophagosome maturation;GO:0072383 plus-end-directed vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VDC1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PV24-1", "uniprot_id": [ { "id": "FIBA_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PV24", "type": "external" } ], "mass": 87429.0, "length": 789, "protein_name": "Fibrinogen alpha chain", "gene_name": "Fga", "organism": "Mouse", "refseq_name": "fibrinogen alpha chain isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_001104518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104518", "type": "external" } ], "gene_names_uniprotkb": "Fga", "gene_names_refseq": "Fga; Fib", "protein_names_uniprotkb": "Fibrinogen alpha chain", "protein_names_refseq": "fibrinogen alpha chain isoform 1 preproprotein; fibrinogen, A alpha polypeptide", "tax_id": 10090, "disease": "hereditary systemic amyloidosis 2 (Disease Ontology:DOID:0050636); brain small vessel disease (Disease Ontology:DOID:0112313); keratoconus (Disease Ontology:DOID:10126); disseminated intravascular coagulation (Disease Ontology:DOID:11247); thrombocytopenia (Disease Ontology:DOID:1588); congenital afibrinogenemia (Disease Ontology:DOID:2236); brain ischemia (Disease Ontology:DOID:2316); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); vascular hemostatic disease (Disease Ontology:DOID:484); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14161); (R-MMU-114608); (R-MMU-216083); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-381426); (R-MMU-5674135); (R-MMU-5686938); (R-MMU-8957275); (R-MMU-9769733)", "pathway_count": 11, "publication_count": 21, "publication_id_list": "10930441;11389004;12629066;15972474;19332769;21183079;21913724;23386199;23487423;26495903;31044023;31219806;33725478;34428180;35257941;35984892;36288343;37453647;37507081;40997131;7649481", "class_list": "", "function": "Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots (PubMed:7649481). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (PubMed:11389004). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood (PubMed:7649481). However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (PubMed:10930441). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (PubMed:7649481). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (PubMed:12629066). May also facilitate the immune response via both innate and T-cell mediated pathways (PubMed:23487423)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway., [RefSeq, PubMed]; This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99K47", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0045087 innate immune response;GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007596 blood coagulation;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "E9PV24-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CS72-1", "uniprot_id": [ { "id": "FLIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CS72", "type": "external" } ], "mass": 137913.0, "length": 1214, "protein_name": "Filamin-A-interacting protein 1", "gene_name": "Filip1", "organism": "Mouse", "refseq_name": "filamin-A-interacting protein 1 isoform b", "refseq_ac": [ { "id": "NP_001074712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074712", "type": "external" } ], "gene_names_uniprotkb": "Filip1", "gene_names_refseq": "5730485H21Rik; Filip1", "protein_names_uniprotkb": "Filamin-A-interacting protein 1; FILIP", "protein_names_refseq": "FILIP; filamin-A-interacting protein 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:70598)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15509752;15794127;21183079;21750661;26655467;29581355;29618024;30016717;35822049;37507081;40021952;40885482", "class_list": "", "function": "By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A., [UniProtKB, UniProtKB]; FILIP is a key molecule that links callosal projections to the pathogenesis of brain disorders., [RefSeq, PubMed]; Knockdown of a novel long non-coding RNA Myolinc impairs the expression of myogenic regulatory factors and formation of multi-nucleated myotubes in cultured myoblasts. Myolinc also regulates the expression of Filip1 in a cis-manner. Similar to Myolinc, knockdown of Filip1 inhibits myogenic differentiation., [RefSeq, PubMed]; Our results reveal a role of FlnA in integrin force transmission and T cell trafficking, [RefSeq, PubMed]; Results suggest that the amount of Filamin A helps migrating neurons determine their mode of migration, multipolar or bipolar, before entering the cortical plate and that FILIP is responsible, at least in part, for Filamin A content., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q059P4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:1903119 protein localization to actin cytoskeleton;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0022038 corpus callosum development;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9CS72-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35601-1", "uniprot_id": [ { "id": "FYB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35601", "type": "external" } ], "mass": 90055.0, "length": 819, "protein_name": "FYN-binding protein 1", "gene_name": "Fyb1", "organism": "Mouse", "refseq_name": "FYN-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001265198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265198", "type": "external" } ], "gene_names_uniprotkb": "Fyb1; Fyb", "gene_names_refseq": "ADAP; B630013F22Rik; FYB-120/130; Fyb1; Fyb; Slap130; p120/130; p120/p130", "protein_names_uniprotkb": "FYN-binding protein 1; ADAP; Adhesion and degranulation promoting adaptor protein; FYB-120/130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein; p120/p130", "protein_names_refseq": "FYN binding protein FYB-130; FYN-T-binding protein; FYN-binding protein 1 isoform 2; SLP-76-associated phosphoprotein; adhesion and degranulation promoting adaptor protein", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (mmu:23880); (R-MMU-202433); (R-MMU-391160)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10469599;10497204;11207596;11567140;11567141;12681493;15477347;17003372;17242355;17947660;19144319;21183079;21750661;21881001;25605945;35637282;9207119", "class_list": "", "function": "ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia., [RefSeq, PubMed]; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (PubMed:10497204, PubMed:9207119). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2 (PubMed:10497204, PubMed:9207119). Involved in platelet activation (PubMed:17003372). Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function and for T cells to respond fully to activating signals., [RefSeq, PubMed]; Regulates TCR-induced integrin clustering and adhesion., [RefSeq, PubMed]; The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2H3", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0070161 anchoring junction", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0072659 protein localization to plasma membrane;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35601-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56959-1", "uniprot_id": [ { "id": "FUS_MOUSE", "url": "https://www.uniprot.org/uniprot/P56959", "type": "external" } ], "mass": 52673.0, "length": 518, "protein_name": "RNA-binding protein FUS", "gene_name": "Fus", "organism": "Mouse", "refseq_name": "RNA-binding protein FUS isoform 1", "refseq_ac": [ { "id": "NP_631888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631888", "type": "external" } ], "gene_names_uniprotkb": "Fus", "gene_names_refseq": "D430004D17Rik; D930039C12Rik; Fus1; Fus; Tls", "protein_names_uniprotkb": "RNA-binding protein FUS; Protein pigpen", "protein_names_refseq": "16) malignant liposarcoma; RNA-binding protein FUS isoform 1; RNA-binding protein FUS; fusion, derived from t(12; hnRNP P2; pigpen protein; protein pigpen; translocated in liposarcoma", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); essential tremor 4 (Disease Ontology:DOID:0111431); sarcoma (Disease Ontology:DOID:1115); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); liposarcoma (Disease Ontology:DOID:3382); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:233908); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;12950080;16317045;16393994;21750661;24129315;25968143;29187734;31219806;32950644;33300544;35820727;37453647;38499486;38822414;38862967;40997131", "class_list": "", "function": "DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (By similarity). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (PubMed:16317045, PubMed:25968143)., [UniProtKB, UniProtKB, PubMed, PubMed]; FUS reads histone H3K36me3 to regulate alternative polyadenylation., [RefSeq, PubMed]; Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS. Publication Status: Online-Only, [RefSeq, PubMed]; The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0048255 mRNA stabilization;GO:0051260 protein homooligomerization;GO:1990000 amyloid fibril formation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P56959-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97379-1", "uniprot_id": [ { "id": "G3BP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97379", "type": "external" } ], "mass": 54088.0, "length": 482, "protein_name": "Ras GTPase-activating protein-binding protein 2", "gene_name": "G3bp2", "organism": "Mouse", "refseq_name": "ras GTPase-activating protein-binding protein 2 isoform a", "refseq_ac": [ { "id": "NP_001074263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074263", "type": "external" } ], "gene_names_uniprotkb": "G3bp2", "gene_names_refseq": "E430034L04Rik; G3BP; G3bp2; mKIAA0660", "protein_names_uniprotkb": "Ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2", "protein_names_refseq": "GTPase activating protein (SH3 domain) binding protein 2; Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2; ras GTPase-activating protein-binding protein 2 isoform a; ras GTPase-activating protein-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:23881)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "15345747;17242355;19144319;21183079;21750661;22357953;22517741;23806337;24129315;25428506;25428507;25605945;30016717;30084848;30779550;31219806;34203471;34428180;34887587;35782098;36288343;36852467;40021952;40885482;9575347", "class_list": "", "function": "G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (By similarity). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL55;Q9R1B8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0140693 molecular condensate scaffold activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0007264 small GTPase-mediated signal transduction;GO:0034063 stress granule assembly;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P97379-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97501-1", "uniprot_id": [ { "id": "FMO3_MOUSE", "url": "https://www.uniprot.org/uniprot/P97501", "type": "external" } ], "mass": 60516.0, "length": 534, "protein_name": "Flavin-containing monooxygenase 3", "gene_name": "Fmo3", "organism": "Mouse", "refseq_name": "flavin-containing monooxygenase 3", "refseq_ac": [ { "id": "NP_032056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032056", "type": "external" } ], "gene_names_uniprotkb": "Fmo3", "gene_names_refseq": "Fmo3", "protein_names_uniprotkb": "Flavin-containing monooxygenase 3; 1.14.13.148; 1.14.13.32; 1.14.13.8; Dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; FMO 3; Hepatic flavin-containing monooxygenase 3; Trimethylamine monooxygenase", "protein_names_refseq": "dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase 3; trimethylamine monooxygenase", "tax_id": 10090, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411); trimethylaminuria (Disease Ontology:DOID:0080361); hypertension (Disease Ontology:DOID:10763); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (mmu:14262); (R-MMU-217271)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "19131326;23177478;30084848;33513464;35613310;35820727;37453647;38320728;9344459", "class_list": "", "function": "Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver., [RefSeq, PubMed]; Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3., [RefSeq, PubMed]; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation., [UniProtKB, PubMed, UniProtKB]; In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016597 amino acid binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0042412 taurine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97501-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U7U3-1", "uniprot_id": [ { "id": "FBX7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U7U3", "type": "external" } ], "mass": 57649.0, "length": 523, "protein_name": "F-box only protein 7", "gene_name": "Fbxo7", "organism": "Mouse", "refseq_name": "F-box only protein 7 isoform 3", "refseq_ac": [ { "id": "NP_001334080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334080", "type": "external" } ], "gene_names_uniprotkb": "Fbxo7", "gene_names_refseq": "2410015K21Rik; A230052G17Rik; Fbxo7", "protein_names_uniprotkb": "F-box only protein 7", "protein_names_refseq": "F-box only protein 7 isoform 3; F-box only protein 7", "tax_id": 10090, "disease": "Parkinson's disease 15 (Disease Ontology:DOID:0060372); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:69754); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16096642;21652635;21750661;24129315;25428506;27497298;31219806;31599954;34428180;34800438;35701754", "class_list": "", "function": "FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity., [RefSeq, PubMed]; Fbxo7 specifically regulated D cyclin/cdk6 complexes; it was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers., [RefSeq, PubMed]; Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (PubMed:27497298). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity)., [UniProtKB, UniProtKB]; The physiological effect of reduced levels of Fbxo7 in mice showed significantly increased pro-B cell and pro-erythroblast populations, consistent with Fbxo7 having an anti-proliferative function and/or a role in promoting maturation of precursor cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBC1;Q8K0A5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0040012 regulation of locomotion;GO:0043524 negative regulation of neuron apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3U7U3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSG3-1", "uniprot_id": [ { "id": "FBX5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSG3", "type": "external" } ], "mass": 47508.0, "length": 421, "protein_name": "F-box only protein 5", "gene_name": "Fbxo5", "organism": "Mouse", "refseq_name": "F-box only protein 5 isoform 1", "refseq_ac": [ { "id": "NP_080271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080271", "type": "external" } ], "gene_names_uniprotkb": "Fbxo5; Emi1", "gene_names_refseq": "2510044I10Rik; Emi1; Fbxo31; Fbxo5", "protein_names_uniprotkb": "F-box only protein 5; Early mitotic inhibitor 1", "protein_names_refseq": "F-box only protein 5 isoform 1; F-box only protein 5; early mitotic inhibitor 1; f-box only protein 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:67141); (R-MMU-174113); (R-MMU-176408); (R-MMU-176417); (R-MMU-68881)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "15526037;16809773;17190794;17875940;21183079;31219806;32782141;34428180;36210013", "class_list": "", "function": "Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:15526037, PubMed:16809773, PubMed:17190794). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:16809773). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase. Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment. As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box co-receptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities. Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (By similarity). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (PubMed:15526037). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (PubMed:17190794). Promotes migration and osteogenic differentiation of mesenchymal stem cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0010997 anaphase-promoting complex binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0072687 meiotic spindle", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:1905322 positive regulation of mesenchymal stem cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TSG3-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTM8-1", "uniprot_id": [ { "id": "FLNA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTM8", "type": "external" } ], "mass": 281222.0, "length": 2647, "protein_name": "Filamin-A", "gene_name": "Flna", "organism": "Mouse", "refseq_name": "filamin-A isoform 3", "refseq_ac": [ { "id": "NP_001390993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001390993", "type": "external" } ], "gene_names_uniprotkb": "Flna; Fln1; Fln", "gene_names_refseq": "ABP-280; Dilp2; F730004A14Rik; Fln1; Flna; GENA 379; filamin-1", "protein_names_uniprotkb": "Filamin-A; ABP-280; Actin-binding protein 280; Alpha-filamin; Endothelial actin-binding protein; FLN-A; Filamin-1; Non-muscle filamin", "protein_names_refseq": "actin-binding protein 280; dilated pupils 2; endothelial actin-binding protein; filamin-A isoform 3; filamin-A; non-muscle filamin", "tax_id": 10090, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); X-linked chronic idiopathic intestinal pseudo-obstruction (Disease Ontology:DOID:0080681); distal myopathy 4 (Disease Ontology:DOID:0111190); X-linked cardiac valvular dysplasia (Disease Ontology:DOID:0111765); otopalatodigital syndrome spectrum disorder (Disease Ontology:DOID:0111782); otopalatodigital syndrome type 1 (Disease Ontology:DOID:0111783); otopalatodigital syndrome type 2 (Disease Ontology:DOID:0111784); frontometaphyseal dysplasia 1 (Disease Ontology:DOID:0111786); Melnick-Needles syndrome (Disease Ontology:DOID:0111788); terminal osseous dysplasia (Disease Ontology:DOID:0112149); tuberous sclerosis (Disease Ontology:DOID:13515); thoracic aortic aneurysm (Disease Ontology:DOID:14004); epilepsy (Disease Ontology:DOID:1826); osteochondrodysplasia (Disease Ontology:DOID:2256); craniosynostosis (Disease Ontology:DOID:2340); myopathy (Disease Ontology:DOID:423); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (R-MMU-114608); (R-MMU-430116); (R-MMU-446353); (R-MMU-5627123)", "pathway_count": 4, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;11807098;17172441;17242355;19131326;19144319;20485683;20713593;21183079;21540332;21709252;21750661;22121117;22645316;23525008;23806337;23890175;24436304;25153642;25358863;29187734;30899004;31219806;32782141;33664708;34428180;34887587;35820727;35984892;36288343;37453647;37507081;38852754;39164108;39627609;9412467", "class_list": "", "function": "Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs (PubMed:17172441). Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (PubMed:20713593). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex., [RefSeq, PubMed]; Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways. Erratum:[J Neurosci. 2025 Jan 29;45(5):e2351242024. doi: 10.1523/JNEUROSCI.2351-24.2024. PMID: 39843238] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 18, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B7FAV0;O54934;Q7TQI1;Q8BLK1;Q8BTN7;Q8VHX5;Q8VHX8;Q99KQ2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0001664 G protein-coupled receptor binding;GO:0015459 potassium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0048680 positive regulation of axon regeneration;GO:0032233 positive regulation of actin filament bundle assembly;GO:0001525 angiogenesis;GO:0007597 blood coagulation, intrinsic pathway", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q8BTM8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C456-1", "uniprot_id": [ { "id": "FRITZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C456", "type": "external" } ], "mass": 81731.0, "length": 722, "protein_name": "WD repeat-containing and planar cell polarity effector protein fritz homolog", "gene_name": "Wdpcp", "organism": "Mouse", "refseq_name": "WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 1", "refseq_ac": [ { "id": "NP_663400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663400", "type": "external" } ], "gene_names_uniprotkb": "Wdpcp", "gene_names_refseq": "Frtz; Wdpcp; homolog-13", "protein_names_uniprotkb": "WD repeat-containing and planar cell polarity effector protein fritz homolog; Homolog-13; WD repeat-containing and planar cell polarity effector protein; mFrtz", "protein_names_refseq": "WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 1; WD repeat-containing and planar cell polarity effector protein fritz homolog; WD repeat-containing protein C2orf86 homolog; mFrtz", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 15 (Disease Ontology:DOID:0110137); congenital heart defects, hamartomas of tongue, and polysyndactyly (Disease Ontology:DOID:0111591); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:216560)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12174196;21750661;22872234;24302887;27158779;29487191;31219806;34225660;34428180;35427153", "class_list": "", "function": "Data suggest that the WD repeat containing planar cell polarity effector (Wdpcp) mutant mice will be a useful tool to dissect the molecular mechanisms that govern the remodeling of the primitive plexus during coronary development. Publication Status: Online-Only, [RefSeq, PubMed]; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (PubMed:35427153)., [UniProtKB, UniProtKB, PubMed, PubMed]; Wdpcp is required for Sept2 recruitment to actin filaments., [RefSeq, PubMed]; Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRR5;Q91ZJ2", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0005930 axoneme;GO:0097541 axonemal basal plate", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0010762 regulation of fibroblast migration;GO:0072359 circulatory system development;GO:0051893 regulation of focal adhesion assembly;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C456-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZP9-1", "uniprot_id": [ { "id": "GA2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZP9", "type": "external" } ], "mass": 72411.0, "length": 678, "protein_name": "GAS2-like protein 1", "gene_name": "Gas2l1", "organism": "Mouse", "refseq_name": "GAS2-like protein 1 isoform beta", "refseq_ac": [ { "id": "NP_001177337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177337", "type": "external" } ], "gene_names_uniprotkb": "Gas2l1", "gene_names_refseq": "4930500E24Rik; D0Jmb1; Gar22; Gas2l1; TU-71.1", "protein_names_uniprotkb": "GAS2-like protein 1; Growth arrest-specific protein 2-like 1", "protein_names_refseq": "GAS2-like protein 1 isoform beta; GAS2-like protein 1; GAS2-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78926)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12584248;21183079;21750661;24129315;24706950;32848054", "class_list": "", "function": "Seems to be involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a member of the Gas2 family, actin-associated proteins expressed at high levels in growth-arrested cells. The gene expression is negatively regulated by serum and growth factors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVG0;Q8K573", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0005856 cytoskeleton", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0051764 actin crosslink formation;GO:0009267 cellular response to starvation;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8JZP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WJ8-1", "uniprot_id": [ { "id": "FUBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WJ8", "type": "external" } ], "mass": 68540.0, "length": 651, "protein_name": "Far upstream element-binding protein 1", "gene_name": "Fubp1", "organism": "Mouse", "refseq_name": "far upstream element-binding protein 1 isoform 6", "refseq_ac": [ { "id": "NP_001342300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001342300", "type": "external" } ], "gene_names_uniprotkb": "Fubp1; D3Ertd330e", "gene_names_refseq": "9530027K12Rik; D3Ertd330e; FBP; Fubp1; Fubp4; Fubp", "protein_names_uniprotkb": "Far upstream element-binding protein 1; FBP; FUSE-binding protein 1", "protein_names_refseq": "FUSE-binding protein 1; far upstream element (FUSE) binding protein 4; far upstream element-binding protein 1 isoform 6; far upstream element-binding protein 1", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colorectal carcinoma (Disease Ontology:DOID:0080199); traumatic brain injury (Disease Ontology:DOID:0081292); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); malignant astrocytoma (Disease Ontology:DOID:3069); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "21183079;21750661;24129315;30871777;31219806;32433053;33005010;36852467;37828378;40885482", "class_list": "", "function": "FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells. Publication Status: Online-Only, [RefSeq, PubMed]; Fubp1 upregulates the mRNA levels of two hexokinase genes, Hk1 and Hk2. We suggest that Fubp1 contributes to cell survival through supporting lactate-Akt-mTOR axis., [RefSeq, PubMed]; Long non-coding RNA small nucleolar RNA host gene 6 aggravates pancreatic cancer through upregulation of far upstream element binding protein 1 by sponging microRNA-26a-5p., [RefSeq, PubMed]; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0Y8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0048103 somatic stem cell division;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91WJ8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X85-1", "uniprot_id": [ { "id": "FLVC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X85", "type": "external" } ], "mass": 60059.0, "length": 551, "protein_name": "Choline/ethanolamine transporter FLVCR2", "gene_name": "Flvcr2", "organism": "Mouse", "refseq_name": "choline/ethanolamine transporter FLVCR2", "refseq_ac": [ { "id": "NP_663422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663422", "type": "external" } ], "gene_names_uniprotkb": "Flvcr2; Mfsd7c", "gene_names_refseq": "CCT; Flvcr2; Mfsd7c", "protein_names_uniprotkb": "Choline/ethanolamine transporter FLVCR2; CCT; Calcium-chelate transporter; Feline leukemia virus subgroup C receptor-related protein 2; Heme transporter FLVCR2; Major facilitator superfamily domain containing 7C; SLC49A5; Solute carrier family 49 member 2", "protein_names_refseq": "calcium-chelate transporter; choline/ethanolamine transporter FLVCR2; feline leukemia virus subgroup C cellular receptor family, member 2; feline leukemia virus subgroup C receptor-related protein 2; heme transporter FLVCR2; major facilitator superfamily domain containing 7C", "tax_id": 10090, "disease": "proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666)", "pathway": " (mmu:217721)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14729055;21183079;32369449;32369453;32973183;38302740;38693257;39300060", "class_list": "", "function": "Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740, PubMed:38693257). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (PubMed:38693257). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (PubMed:38693257). Also mediates transport of ethanolamine (By similarity). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (PubMed:38693257). However, the presence of an inwardly directed proton gradient enhances choline uptake (PubMed:38693257). Also acts as a heme b transporter (By similarity). Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis (By similarity). At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis (PubMed:32973183). Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis (PubMed:32973183)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome., [RefSeq, PubMed]; Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier., [RefSeq, PubMed]; MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; MFSD7c functions as a transporter of choline at the blood-brain barrier., [RefSeq, PubMed]; Structural and molecular basis of choline uptake into the brain by FLVCR2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0E9", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0033265 choline binding;GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097102 endothelial tip cell fate specification;GO:0001701 in utero embryonic development;GO:0006629 lipid metabolic process;GO:0030324 lung development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91X85-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1M7-1", "uniprot_id": [ { "id": "FKB11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1M7", "type": "external" } ], "mass": 22137.0, "length": 201, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP11", "gene_name": "Fkbp11", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor", "refseq_ac": [ { "id": "NP_077131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077131", "type": "external" } ], "gene_names_uniprotkb": "Fkbp11", "gene_names_refseq": "1110002O23Rik; FKBP-11; Fkbp11", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP11; 19 kDa FK506-binding protein; 19 kDa FKBP; 5.2.1.8; FK506-binding protein 11; FKBP-11; FKBP-19; PPIase FKBP11; Rotamase", "protein_names_refseq": "19 kDa FK506-binding protein; 19 kDa FKBP; FKBP-19; PPIase FKBP11; peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor; peptidyl-prolyl cis-trans isomerase FKBP11; rotamase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66120)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20838829;24058703;30221722;34428180;35793654;35793657;37453647", "class_list": "", "function": "Diabesity? No worries, FKBP11 to the rescue., [RefSeq, PubMed]; FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity., [RefSeq, PubMed]; PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB]; These results indicate that the S-palmitoylation on IFITM5 promotes the interaction with FKBP11. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that the UPR protein FKBP11 may protect IECs against IFNg/TNFa induced apoptosis by inhibiting the ER stressassociated JNK/caspase apoptotic pathway in Crohn's disease Erratum:[Mol Med Rep. 2024 Mar;29(3):50. doi: 10.3892/mmr.2024.13172. PMID: 38299256], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRE4", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D1M7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTS2-1", "uniprot_id": [ { "id": "FUT8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTS2", "type": "external" } ], "mass": 66557.0, "length": 575, "protein_name": "Alpha-(1,6)-fucosyltransferase", "gene_name": "Fut8", "organism": "Mouse", "refseq_name": "alpha-(1,6)-fucosyltransferase isoform 1", "refseq_ac": [ { "id": "NP_001239543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239543", "type": "external" } ], "gene_names_uniprotkb": "Fut8", "gene_names_refseq": "Fut8", "protein_names_uniprotkb": "Alpha-(1,6)-fucosyltransferase; 2.4.1.68; Alpha1-6FucT; Fucosyltransferase 8; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase", "protein_names_refseq": "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; alpha-(1,6)-fucosyltransferase isoform 1; alpha-(1,6)-fucosyltransferase; alpha1-6FucT; glycoprotein 6-alpha-L-fucosyltransferase", "tax_id": 10090, "disease": "pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:53618); (R-MMU-975578)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10902914;12427744;21183079;26495903;31219806;34428180;36252012;37432656;38523237", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Fucosylates the reducing GlcNAc residue in complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs. Fully converts Fc glycoforms containing one or two terminal GlcNAc moieties (G0-GlcNAc and G0)., [UniProtKB, UniProtKB, PubMed]; Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway., [RefSeq, PubMed]; Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion injury-induced renal interstitial inflammation transition to fibrosis via the TLR3-NF-kappaB pathway., [RefSeq, PubMed]; The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543F5;Q921U1", "ec_number_list": [ { "id": "2.4.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.68", "type": "external" } ], "go_molecular_function": "GO:0046921 alpha-(1->6)-fucosyltransferase activity;GO:0017124 SH3 domain binding;GO:0016757 glycosyltransferase activity;GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 6717, "hit_score": 1.0, "record_id": "Q9WTS2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVR4-1", "uniprot_id": [ { "id": "FXR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVR4", "type": "external" } ], "mass": 73743.0, "length": 673, "protein_name": "RNA-binding protein FXR2", "gene_name": "Fxr2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fxr2; Fxr2h", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein FXR2; FXR2P", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); fragile X syndrome (Disease Ontology:DOID:14261); glucose metabolism disease (Disease Ontology:DOID:4194); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10524236;11438699;11875043;15592455;16675531;17242355;18930145;21183079;21658585;21750661;40885482", "class_list": "", "function": "mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (PubMed:21658585). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:21658585). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (PubMed:21658585)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVR5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0045727 positive regulation of translation;GO:0048513 animal organ development;GO:0061157 mRNA destabilization;GO:0048170 positive regulation of long-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WVR4-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3J9-1", "uniprot_id": [ { "id": "GPC5C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3J9", "type": "external" } ], "mass": 48422.0, "length": 440, "protein_name": "G protein-coupled receptor family C group 5 member C", "gene_name": "Gprc5c", "organism": "Mouse", "refseq_name": "G-protein coupled receptor family C group 5 member C isoform b precursor", "refseq_ac": [ { "id": "NP_001103808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103808", "type": "external" } ], "gene_names_uniprotkb": "Gprc5c; Raig3", "gene_names_refseq": "1110028I06Rik; 3200002M13Rik; Gprc5c; Raig3", "protein_names_uniprotkb": "G protein-coupled receptor family C group 5 member C; RAIG-3; Retinoic acid-induced gene 3 protein", "protein_names_refseq": "G-protein coupled receptor family C group 5 member C isoform b precursor; RAIG-3; retinoic acid inducible protein 3; retinoic acid-induced gene 3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70355)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15240697;21183079;21750661;21840300;29196502;37418589;37558192;38110903", "class_list": "", "function": "G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals., [RefSeq, PubMed]; GPRC5C does not affect behavior, though it has a high sequence similarity to GPRC5B., [RefSeq, PubMed]; GPRC5C regulates the composition of cilia in the olfactory system. Publication Status: Online-Only, [RefSeq, PubMed]; Gprc5c KO mice have altered acid-base homeostasis and reduced NHE3 activity in the kidney., [RefSeq, PubMed]; The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response., [RefSeq, PubMed]; This retinoic acid-inducible G protein-coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0H0", "ec_number_list": [], "go_molecular_function": "GO:0005118 sevenless binding;GO:0004930 G protein-coupled receptor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043235 receptor complex;GO:0070062 extracellular exosome", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K3J9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62881-1", "uniprot_id": [ { "id": "GNB5_MOUSE", "url": "https://www.uniprot.org/uniprot/P62881", "type": "external" } ], "mass": 43565.0, "length": 395, "protein_name": "Guanine nucleotide-binding protein subunit beta-5", "gene_name": "Gnb5", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein subunit beta-5 isoform 1", "refseq_ac": [ { "id": "NP_034443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034443", "type": "external" } ], "gene_names_uniprotkb": "Gnb5", "gene_names_refseq": "GBS; Gbeta5; Gnb5; Hg2e; flr", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta-5; Gbeta5; Transducin beta chain 5", "protein_names_refseq": "flailer; flail; guanine nucleotide binding protein, beta 5; guanine nucleotide-binding protein subunit beta-5 isoform 1; guanine nucleotide-binding protein subunit beta-5; heterotrimeric guanine nucleotide-binding protein 2e; hug; transducin beta chain 5", "tax_id": 10090, "disease": "Lodder-Merla syndrome type 1 with impaired intellectual development and cardiac arrhythmia (Disease Ontology:DOID:0081008)", "pathway": " (mmu:14697); (R-MMU-1296041); (R-MMU-202040); (R-MMU-2514859); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 29, "publication_count": 13, "publication_id_list": "12119397;16908407;18204463;21750661;25428506;25605945;31219806;31311860;34428180;34793198;37219953;8071339;8910430", "class_list": "", "function": "Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein-coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Specific regulation of mechanical nociception by Gbeta5 involves GABA-B receptors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35354;P54314;Q91WB3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0051087 protein-folding chaperone binding;GO:0032794 GTPase activating protein binding;GO:0030159 signaling receptor complex adaptor activity;GO:0031682 G-protein gamma-subunit binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:1990603 dark adaptation;GO:0036367 light adaption", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P62881-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UNH4-1", "uniprot_id": [ { "id": "GRIN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UNH4", "type": "external" } ], "mass": 95496.0, "length": 932, "protein_name": "G protein-regulated inducer of neurite outgrowth 1", "gene_name": "Gprin1", "organism": "Mouse", "refseq_name": "G protein-regulated inducer of neurite outgrowth 1", "refseq_ac": [ { "id": "NP_001303639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303639", "type": "external" } ], "gene_names_uniprotkb": "Gprin1", "gene_names_refseq": "Gprin1; Z16", "protein_names_uniprotkb": "G protein-regulated inducer of neurite outgrowth 1; GRIN1", "protein_names_refseq": "G protein-regulated inducer of neurite outgrowth 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26913)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10480904;15345747;15585744;16452087;17114649;21183079;22517741;22645316;22872234;25428506;32848054;34203471;34678516;40684658;40885482", "class_list": "", "function": "May be involved in neurite outgrowth., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGF9;Q9QZY2", "ec_number_list": [], "go_molecular_function": "GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030426 growth cone", "go_biological_process": "GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q3UNH4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60631-1", "uniprot_id": [ { "id": "GRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60631", "type": "external" } ], "mass": 25238.0, "length": 217, "protein_name": "Growth factor receptor-bound protein 2", "gene_name": "Grb2", "organism": "Mouse", "refseq_name": "growth factor receptor-bound protein 2", "refseq_ac": [ { "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865", "type": "external" } ], "gene_names_uniprotkb": "Grb2", "gene_names_refseq": "Ash; Grb2", "protein_names_uniprotkb": "Growth factor receptor-bound protein 2; Adapter protein GRB2; SH2/SH3 adapter GRB2", "protein_names_refseq": "SH2/SH3 adapter GRB2; adapter protein GRB2; growth factor receptor-bound protein 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 114 (Disease Ontology:DOID:0111642); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (mmu:14784); (R-MMU-109704); (R-MMU-112412); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-1295596); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-167044); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-186763); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-2029482); (R-MMU-210993); (R-MMU-2179392); (R-MMU-2424491); (R-MMU-2428933); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-354194); (R-MMU-375165); (R-MMU-389359); (R-MMU-391160); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5663213); (R-MMU-5673001); (R-MMU-6807004); (R-MMU-6811558); (R-MMU-74749); (R-MMU-74751); (R-MMU-8851805); (R-MMU-8851907); (R-MMU-8853659); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8865999); (R-MMU-8875555); (R-MMU-8875656); (R-MMU-8983432); (R-MMU-9013420); (R-MMU-9027284); (R-MMU-9028731); (R-MMU-912526); (R-MMU-912631); (R-MMU-9607240); (R-MMU-9674555); (R-MMU-983695); (R-MMU-9842663); (R-MMU-9927353)", "pathway_count": 69, "publication_count": 41, "publication_id_list": "10068651;10330178;10377264;10521483;11113178;11463797;11551227;11571277;11711534;12925710;14610044;15477348;15477350;16249387;16475793;16582911;16966330;19597497;19597498;19805304;20398064;20644716;21543326;21750661;21930792;22561606;26552706;28098138;28290451;28964849;34697226;38459011;38862918;7689150;7997267;8943348;9135122;9312046;9395447;9569023;9722576", "class_list": "", "function": "Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Mechanistically, inhibits RAS-ERK signaling and downstream cell proliferation by competing with GRB2 for SOS1 binding and thus by regulating SOS1 membrane recruitment., [UniProtKB, UniProtKB]; ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:28964849). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis. Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells. Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2. In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation. Also functions a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:34697226). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1. Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1. Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks. Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process., [UniProtKB, UniProtKB, PubMed, PubMed]; The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61240", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0031623 receptor internalization;GO:0031295 T cell costimulation;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q60631-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PT1-1", "uniprot_id": [ { "id": "GDIR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PT1", "type": "external" } ], "mass": 23407.0, "length": 204, "protein_name": "Rho GDP-dissociation inhibitor 1", "gene_name": "Arhgdia", "organism": "Mouse", "refseq_name": "rho GDP-dissociation inhibitor 1", "refseq_ac": [ { "id": "NP_598557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598557", "type": "external" } ], "gene_names_uniprotkb": "Arhgdia; C87222; Gdi1", "gene_names_refseq": "5330430M07Rik; Arhgdia; Gdi-1; Rho GDI alpha; Rho-GDI; RhoDGI; RhoGDI-1; rho GDI 1; rho-GDI alpha", "protein_names_uniprotkb": "Rho GDP-dissociation inhibitor 1; GDI-1; Rho GDI 1; Rho-GDI alpha", "protein_names_refseq": "Rho GDIalpha; Rho GDP dissociation inhibitor (GDI) alpha; rho GDP-dissociation inhibitor 1", "tax_id": 10090, "disease": "nephrotic syndrome type 8 (Disease Ontology:DOID:0080389); hypertension (Disease Ontology:DOID:10763); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (mmu:192662); (R-MMU-193634); (R-MMU-209563); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013407); (R-MMU-9013408)", "pathway_count": 10, "publication_count": 23, "publication_id_list": "11923206;16075062;17242355;19029984;20696765;21183079;22628549;23434736;23806337;25428506;26495903;26740625;32152506;33320336;34428180;35080740;35820727;36288343;36823181;37364105;37453647;37507081;39927985", "class_list": "", "function": "A direct interaction between RhoGDIalpha/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia., [RefSeq, PubMed]; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1., [UniProtKB, PubMed, PubMed, PubMed]; Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation., [RefSeq, PubMed]; RhoGDIalpha regulates spermatogenesis through Rac1/cofilin/F-actin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The Rho guanine dissociation inhibitor alpha inhibits skeletal muscle Rac1 activity and insulin action., [RefSeq, PubMed]; The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9P6;Q8BPI0;Q99KC4", "ec_number_list": [], "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0005096 GTPase activator activity;GO:0005504 fatty acid binding;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0030336 negative regulation of cell migration;GO:0007266 Rho protein signal transduction;GO:0032880 regulation of protein localization;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q99PT1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Z7-1", "uniprot_id": [ { "id": "KLF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0Z7", "type": "external" } ], "mass": 49754.0, "length": 446, "protein_name": "Krueppel-like factor 5", "gene_name": "Klf5", "organism": "Mouse", "refseq_name": "Krueppel-like factor 5", "refseq_ac": [ { "id": "NP_033899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033899", "type": "external" } ], "gene_names_uniprotkb": "Klf5; Bteb2; Iklf", "gene_names_refseq": "4930520J07Rik; Bteb2; CKLF; IKLF; Klf5", "protein_names_uniprotkb": "Krueppel-like factor 5; BTE-binding protein 2; Basic transcription element-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2", "protein_names_refseq": "BTE-binding protein 2; Krueppel-like factor 5; Kruppel-like factor 5; basic transcription element-binding protein 2; intestinal-enriched krueppel-like factor; transcription factor BTEB2", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); intracranial aneurysm (Disease Ontology:DOID:10941); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:12224)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10767086;11152667;31219806;34428180;36210013;36852467;38781024;39412062;9973612", "class_list": "", "function": "HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis., [RefSeq, PubMed]; Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Study shows that KLF5 is a positive regulator of cellular proliferation as demonstrated by the appearance of a transformed phenotype in cells overexpressing KLF5, [RefSeq, PubMed]; Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9JMI2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014816 skeletal muscle satellite cell differentiation;GO:1990859 cellular response to endothelin;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06240-1", "uniprot_id": [ { "id": "LCK_MOUSE", "url": "https://www.uniprot.org/uniprot/P06240", "type": "external" } ], "mass": 57943.0, "length": 509, "protein_name": "Proto-oncogene tyrosine-protein kinase LCK", "gene_name": "Lck", "organism": "Mouse", "refseq_name": "proto-oncogene tyrosine-protein kinase LCK isoform b", "refseq_ac": [ { "id": "NP_001155905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155905", "type": "external" } ], "gene_names_uniprotkb": "Lck; Lsk-t", "gene_names_refseq": "Hck-3; Lck; Lskt; Lsk; p56; p56Lck", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase LCK; 2.7.10.2; LSK; Leukocyte C-terminal Src kinase; Lymphocyte cell-specific protein-tyrosine kinase; p56-LCK", "protein_names_refseq": "leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK isoform b; proto-oncogene tyrosine-protein kinase LCK", "tax_id": 10090, "disease": "immunodeficiency 22 (Disease Ontology:DOID:0111937); intestinal cancer (Disease Ontology:DOID:10155); allergic conjunctivitis (Disease Ontology:DOID:11204); cancer (Disease Ontology:DOID:162); Goldenhar syndrome (Disease Ontology:DOID:2907); carcinoma (Disease Ontology:DOID:305); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); kidney disease (Disease Ontology:DOID:557); retinal degeneration (Disease Ontology:DOID:8466); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:16818); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-210990); (R-MMU-2424491); (R-MMU-389356); (R-MMU-389357); (R-MMU-389359); (R-MMU-389513); (R-MMU-389948); (R-MMU-6811558); (R-MMU-9013407); (R-MMU-9020558); (R-MMU-9706374)", "pathway_count": 20, "publication_count": 48, "publication_id_list": "10646608;11294838;12218089;1279202;1311128;1579166;16446380;1706070;1708890;17277109;18981123;2107025;21183079;2118992;21750661;2250907;22523384;22872234;2416464;2468122;25595912;2850479;3081813;31219806;33684096;3380790;33888137;34428180;3501824;36210013;36692275;37233920;37370140;39627609;7694287;7980442;7997241;8077654;8226850;8258696;8371758;8413237;8413300;8421674;8441403;8756658;9658584;9973453", "class_list": "", "function": "LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Lymphocyte-Specific Protein Tyrosine Kinase Contributes to Spontaneous Regression of Liver Fibrosis may by Interacting with Suppressor of Cytokine Signaling 1., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR-CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR-CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP (By similarity). Interacts with UNC119; this interaction plays a crucial role in activation of LCK (By similarity)., [UniProtKB]; [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61794;Q61795;Q62320;Q91X65", "ec_number_list": [ { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P06240-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26687-1", "uniprot_id": [ { "id": "TWST1_MOUSE", "url": "https://www.uniprot.org/uniprot/P26687", "type": "external" } ], "mass": 21198.0, "length": 206, "protein_name": "Twist-related protein 1", "gene_name": "Twist1", "organism": "Mouse", "refseq_name": "twist-related protein 1", "refseq_ac": [ { "id": "NP_035788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035788", "type": "external" } ], "gene_names_uniprotkb": "Twist1; Twist", "gene_names_refseq": "M-Twist; Pde; Ska10; Ska; Twist1; Twist; bHLHa38; pdt", "protein_names_uniprotkb": "Twist-related protein 1; M-twist", "protein_names_refseq": "Pluridigite; charlie chaplin; polydactyly EMS; twist gene homolog 1; twist homolog 1; twist-related protein 1", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); craniosynostosis 1 (Disease Ontology:DOID:0061010); Sweeney-Cox syndrome (Disease Ontology:DOID:0080538); acrocephalosyndactylia (Disease Ontology:DOID:12960); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:22160); (R-MMU-9764725)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12553906;14645221;16502419;17893140;1840517;21559426;23395635;25892968;27281171;31383001;9343420", "class_list": "", "function": "Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. This gene encodes a bHLH transcription factor that is evolutionarily conserved from invertebrates to humans, and was originally identified in Drosophila as an essential gene involved in early mesoderm development and dorsal-ventral patterning in the embryo. This protein plays a role in cancer by regulating the epithelial-mesenchymal transition (EMT), a process that is critical for metastasis initiation, and promoting tumor progression. Mutations in the human gene are associated with Saethre-Chotzen syndrome (SCS). Mice with heterozygous mutations in this gene exhibit cranofacial and structural defects similar to those seen in human SCS patients. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0060900 embryonic camera-type eye formation;GO:2000793 cell proliferation involved in heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P26687-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58463-1", "uniprot_id": [ { "id": "FOXP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P58463", "type": "external" } ], "mass": 79819.0, "length": 714, "protein_name": "Forkhead box protein P2", "gene_name": "Foxp2", "organism": "Mouse", "refseq_name": "forkhead box protein P2 isoform 2", "refseq_ac": [ { "id": "NP_001273536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273536", "type": "external" } ], "gene_names_uniprotkb": "Foxp2", "gene_names_refseq": "2810043D05Rik; CAG-16; D0Kist7; Foxp2", "protein_names_uniprotkb": "Forkhead box protein P2", "protein_names_refseq": "forkhead box protein P2 isoform 2; forkhead box protein P2", "tax_id": 10090, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); autism spectrum disorder (Disease Ontology:DOID:0060041); speech-language disorder-1 (Disease Ontology:DOID:0111275); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); articulation disorder (Disease Ontology:DOID:4186); dyslexia (Disease Ontology:DOID:4428); schizophrenia (Disease Ontology:DOID:5419); language disorder (Disease Ontology:DOID:93)", "pathway": " (mmu:114142)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11358962;12192408;14516685;14701752;21750661;24179158;25428506;34428180", "class_list": "", "function": "Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PD37;Q8C4F0;Q8R441", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048286 lung alveolus development;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P58463-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEG6-1", "uniprot_id": [ { "id": "CNO6L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEG6", "type": "external" } ], "mass": 63023.0, "length": 555, "protein_name": "CCR4-NOT transcription complex subunit 6-like", "gene_name": "Cnot6l", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 6-like isoform 1", "refseq_ac": [ { "id": "NP_001272440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272440", "type": "external" } ], "gene_names_uniprotkb": "Cnot6l", "gene_names_refseq": "4932442K20Rik; Cnot6l", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 6-like; 3.1.13.4", "protein_names_refseq": "CCR4-NOT transcription complex subunit 6-like isoform 1", "tax_id": 10090, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:231464); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "17452450;20133598;21078877;21750661;22367759;36001654;39433858", "class_list": "", "function": "CCR4b may be involved in various cellular events that include cell proliferation., [RefSeq, PubMed]; High expression of CNOT6L contributes to the negative development of type 2 diabetes. Erratum:[Sci Rep. 2024 Dec 23;14(1):30627. doi: 10.1038/s41598-024-83685-w. PMID: 39715822] Publication Status: Online-Only, [RefSeq, PubMed]; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9M0;Q8C0P4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VEG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2I1-1", "uniprot_id": [ { "id": "FNTB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2I1", "type": "external" } ], "mass": 48820.0, "length": 437, "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "Fntb", "organism": "Mouse", "refseq_name": "protein farnesyltransferase subunit beta isoform 1", "refseq_ac": [ { "id": "NP_666039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666039", "type": "external" } ], "gene_names_uniprotkb": "Fntb", "gene_names_refseq": "2010013E13Rik; Fntb", "protein_names_uniprotkb": "Protein farnesyltransferase subunit beta; 2.5.1.58; CAAX farnesyltransferase subunit beta; FTase-beta; Ras proteins prenyltransferase subunit beta", "protein_names_refseq": "CAAX farnesyltransferase subunit beta; FTase-beta; protein farnesyltransferase subunit beta isoform 1; protein farnesyltransferase subunit beta; ras proteins prenyltransferase subunit beta", "tax_id": 10090, "disease": "anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (mmu:110606); (R-MMU-2514859); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15837621;17652517;20106865;21183079;21520375;21750661;21952136;25428507;25605945;34315531;34428180;35820727", "class_list": "", "function": "Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes., [RefSeq, PubMed]; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; FTase is essential for embryonic development, but dispensable for adult homeostasis. Elimination of FTase during tumor progression had a limited but significant inhibitory effect on tumor development., [RefSeq, PubMed]; Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" } ], "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0010698 acetyltransferase activator activity;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005965 protein farnesyltransferase complex;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0018343 protein farnesylation;GO:0045787 positive regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K2I1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62059-1", "uniprot_id": [ { "id": "CSPG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62059", "type": "external" } ], "mass": 366787.0, "length": 3357, "protein_name": "Versican core protein", "gene_name": "Vcan", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vcan; Cspg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Versican core protein; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; Large fibroblast proteoglycan; PG-M", "protein_names_refseq": "", "tax_id": 10090, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:13003); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101); (R-MMU-3000178); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10400671;17242355;21183079;21750661;23233679;24220035;25428506;29777959;30084848;30899004;31219806;31599954;33300544;34428180;40885482;7822336;7876137", "class_list": "glycogene", "function": "May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 25, "predicted_n_glycosites": 12, "predicted_o_glycosites": 13, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 116, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 2, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "Q62058;Q9CUU0", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding;GO:0005540 hyaluronic acid binding;GO:0008160 protein tyrosine phosphatase activator activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0001657 ureteric bud development", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q62059-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXM0-1", "uniprot_id": [ { "id": "CHODL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXM0", "type": "external" } ], "mass": 30331.0, "length": 273, "protein_name": "Chondrolectin", "gene_name": "Chodl", "organism": "Mouse", "refseq_name": "chondrolectin isoform 1 precursor", "refseq_ac": [ { "id": "NP_624360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_624360", "type": "external" } ], "gene_names_uniprotkb": "Chodl", "gene_names_refseq": "3110074E07Rik; Chodl; MT75; PRED12", "protein_names_uniprotkb": "Chondrolectin; Transmembrane protein MT75", "protein_names_refseq": "chondrolectin isoform 1 precursor; transmembrane protein MT75", "tax_id": 10090, "disease": "", "pathway": " (mmu:246048)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12711387;18161010;20019802;20437528;21750661;24067532;25428506", "class_list": "glycogene", "function": "May play a role in the development of the nervous system such as in neurite outgrowth and elongation (PubMed:24067532). May be involved in motor axon growth and guidance (By similarity)., [UniProtKB, PubMed, UniProtKB]; The function of chodl was investigated by searching for its protein interaction partners., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3US20;Q8BVU2;Q8VI31", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0050772 positive regulation of axonogenesis;GO:0010975 regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CXM0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R344-1", "uniprot_id": [ { "id": "CCD12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R344", "type": "external" } ], "mass": 18891.0, "length": 166, "protein_name": "Coiled-coil domain-containing protein 12", "gene_name": "Ccdc12", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 12", "refseq_ac": [ { "id": "NP_082588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082588", "type": "external" } ], "gene_names_uniprotkb": "Ccdc12", "gene_names_refseq": "2700094L05Rik; Ccdc12", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 12", "protein_names_refseq": "coiled-coil domain-containing protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:72654); (R-MMU-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;23806337", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZH5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0071014 post-mRNA release spliceosomal complex;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R344-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TY0-1", "uniprot_id": [ { "id": "FNBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TY0", "type": "external" } ], "mass": 71344.0, "length": 616, "protein_name": "Formin-binding protein 1", "gene_name": "Fnbp1", "organism": "Mouse", "refseq_name": "formin-binding protein 1 isoform a", "refseq_ac": [ { "id": "NP_001033789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033789", "type": "external" } ], "gene_names_uniprotkb": "Fnbp1; Fbp17; Kiaa0554", "gene_names_refseq": "1110057E06Rik; 2210010H06Rik; FBP1; Fbp17; Fnbp1", "protein_names_uniprotkb": "Formin-binding protein 1; Formin-binding protein 17", "protein_names_refseq": "formin binding protein 17; formin-binding protein 1 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:14269); (R-MMU-8856828); (R-MMU-9013406); (R-MMU-9696270)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "15252009;17947660;19144319;21183079;21750661;31219806;34428180;36210013;38945423", "class_list": "", "function": "FBP17 interacts with dynamin and regulates endocytosis by forming vesicotubular structures., [RefSeq, PubMed]; Formin Binding Protein 1 (FNBP1) regulates non-canonical Wnt signaling and vertebrate gastrulation., [RefSeq, PubMed]; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ40;A2AQ46;Q3TA45;Q3TCW9;Q3U081;Q3UPI7;Q8C727;Q99L37", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0005938 cell cortex;GO:0005764 lysosome", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80TY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLQ2-1", "uniprot_id": [ { "id": "GIT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLQ2", "type": "external" } ], "mass": 78766.0, "length": 708, "protein_name": "ARF GTPase-activating protein GIT2", "gene_name": "Git2", "organism": "Mouse", "refseq_name": "ARF GTPase-activating protein GIT2 isoform 1", "refseq_ac": [ { "id": "NP_062808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062808", "type": "external" } ], "gene_names_uniprotkb": "Git2", "gene_names_refseq": "1500036H07Rik; 5830420E16Rik; 6430510B20Rik; 9630056M03Rik; B230104M05Rik; CAT2; Git2; mKIAA0148", "protein_names_uniprotkb": "ARF GTPase-activating protein GIT2; ARF GAP GIT2; CAT-2; CAT2; Cool-interacting tyrosine-phosphorylated protein 2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2", "protein_names_refseq": "ARF GAP GIT2; ARF GTPase activating protein 2; ARF GTPase-activating protein GIT2 isoform 1; ARF GTPase-activating protein GIT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; cool-interacting tyrosine-phosphorylated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26431); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10330411;10428811;16715100;17242355;17310244;21183079;21750661;30059200;31219806;32782141;36852467;38370406;39074614;39627609;40021952", "class_list": "", "function": "GIT2 links chemotaxis and superoxide production in neutrophils.Loss of GIT2 in vivo leads to an immunodeficient state., [RefSeq, PubMed]; GTPase-activating protein for ADP ribosylation factor family members, including ARF1., [UniProtKB, UniProtKB]; Git2 deficiency promotes MDSCs recruitment in intestine via NF-kappaB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis., [RefSeq, PubMed]; Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QPU7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005654 nucleoplasm;GO:0045202 synapse;GO:0098793 presynapse;GO:0150034 distal axon", "go_biological_process": "GO:0007420 brain development;GO:0036465 synaptic vesicle recycling;GO:0048266 behavioral response to pain;GO:0032012 regulation of ARF protein signal transduction;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9JLQ2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KY4-1", "uniprot_id": [ { "id": "GAK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KY4", "type": "external" } ], "mass": 143641.0, "length": 1305, "protein_name": "Cyclin-G-associated kinase", "gene_name": "Gak", "organism": "Mouse", "refseq_name": "cyclin-G-associated kinase isoform 2", "refseq_ac": [ { "id": "NP_001268980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268980", "type": "external" } ], "gene_names_uniprotkb": "Gak", "gene_names_refseq": "D130045N16Rik; Gak", "protein_names_uniprotkb": "Cyclin-G-associated kinase; 2.7.11.1", "protein_names_refseq": "cyclin-G-associated kinase isoform 2; dnaJ homolog subfamily C member 26", "tax_id": 10090, "disease": "Parkinson's disease 19A (Disease Ontology:DOID:0060891); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:231580); (R-MMU-432722); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18434600;21183079;21750661;24129315;25428506;26345367;28315936;30899004;31219806;32848054;33208557;33300544;34428180;40885482", "class_list": "", "function": "Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GAK deletion blocks development and causes lethality in adult animals by disrupting clathrin-mediated endocytosis, [RefSeq, PubMed]; Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. Publication Status: Online-Only, [RefSeq, PubMed]; PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1I8;Q6P9S5;Q8BM74;Q8K0Q4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030276 clathrin binding;GO:0030332 cyclin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0061436 establishment of skin barrier;GO:0072659 protein localization to plasma membrane;GO:0010977 negative regulation of neuron projection development;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q99KY4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810L3-1", "uniprot_id": [ { "id": "CHFR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810L3", "type": "external" } ], "mass": 73871.0, "length": 664, "protein_name": "E3 ubiquitin-protein ligase CHFR", "gene_name": "Chfr", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase CHFR isoform 1", "refseq_ac": [ { "id": "NP_001276506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276506", "type": "external" } ], "gene_names_uniprotkb": "Chfr", "gene_names_refseq": "5730484M20Rik; C230082M18; Chfr; RNF116", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHFR; 2.3.2.27; Checkpoint with forkhead and RING finger domains protein; RING-type E3 ubiquitin transferase CHFR", "protein_names_refseq": "E3 ubiquitin-protein ligase CHFR isoform 1; E3 ubiquitin-protein ligase CHFR; RING-type E3 ubiquitin transferase CHFR", "tax_id": 10090, "disease": "", "pathway": " (mmu:231600)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15467728;15793587;17525332;19690386;21245198;21706008;21750661;22337872;25428506;26566864;31219806;37852964", "class_list": "", "function": "CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells., [RefSeq, PubMed]; Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity)., [UniProtKB, UniProtKB, PubMed]; Mice with deficiencies in both Chfr and Mlh1 (the gene that encodes the DNA mismatch-repair protein Mlh1) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes., [RefSeq, PubMed]; PML bodies control the distribution, dynamics and function of CHFR, [RefSeq, PubMed]; RNF8 and Chfr, function together to activate ATM and maintain genomic stability in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Stil protein regulates centrosome integrity and mitosis through suppression of Chfr., [RefSeq, PubMed]; The interaction between CHFR and PARP-1 plays an important role in cell cycle regulation and cancer therapeutic strategies., [RefSeq, PubMed]; Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFD8;Q3U233;Q3U4U9;Q3UGJ9;Q8BJZ9;Q8BWH4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000166 nucleotide binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0031398 positive regulation of protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q810L3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56671-1", "uniprot_id": [ { "id": "MAZ_MOUSE", "url": "https://www.uniprot.org/uniprot/P56671", "type": "external" } ], "mass": 48770.0, "length": 477, "protein_name": "Myc-associated zinc finger protein", "gene_name": "Maz", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Maz", "gene_names_refseq": "", "protein_names_uniprotkb": "Myc-associated zinc finger protein; MAZI; Pur-1; Purine-binding transcription factor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17188)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10092852;1454839;21750661;26089202;30084848;31219806;40885482;40997131", "class_list": "", "function": "Transcriptional regulator (By similarity). Acts as a transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide (PubMed:1454839)., [UniProtKB, UniProtKB, PubMed]; Transcriptional regulator. Acts as a transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1W0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P56671-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFX1-1", "uniprot_id": [ { "id": "G6PE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFX1", "type": "external" } ], "mass": 88928.0, "length": 789, "protein_name": "GDH/6PGL endoplasmic bifunctional protein", "gene_name": "H6pd", "organism": "Mouse", "refseq_name": "GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_001277933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277933", "type": "external" } ], "gene_names_uniprotkb": "H6pd", "gene_names_refseq": "G6pd1; Gpd-1; Gpd1; H6pd", "protein_names_uniprotkb": "GDH/6PGL endoplasmic bifunctional protein; 1.1.1.363; 1.1.1.47; Glucose 1-dehydrogenase; Glucose-6-phosphate dehydrogenase", "protein_names_refseq": "GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor; GDH/6PGL endoplasmic bifunctional protein; glucose 1-dehydrogenase; glucose-6-phosphate dehydrogenase 1", "tax_id": 10090, "disease": "cortisone reductase deficiency (Disease Ontology:DOID:0090139); cortisone reductase deficiency 1 (Disease Ontology:DOID:0090141); multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:100198)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;12831846;16356929;17656460;18218694;18222920;21750661;23806337;25428506;26740625;28749080;29568102;30899004;31127649;31616917;31696216;34428180;36210013;37453647;37507081;40997131;4169027", "class_list": "glycogene", "function": "Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (PubMed:12831846, PubMed:16356929, PubMed:18222920, PubMed:4169027). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12831846, PubMed:18222920, PubMed:4169027). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (PubMed:12831846). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (PubMed:12831846). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12831846, PubMed:16356929, PubMed:17656460, PubMed:18222920). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:16356929)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuroprotection by glucose-6-phosphate dehydrogenase and the pentose phosphate pathway. Review article, [RefSeq, PubMed]; Reduction in adipose-specific H6PDH leads to reduced fat cell-specific production of glucocorticoids and decreased abdominal fat, [RefSeq, PubMed]; Studied expression levels and signal pathways involved with hexose-6-phosphate dehydrogenase in mouse model of diet induced visceral adiposity., [RefSeq, PubMed]; We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 56, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A7A9;B2KGW7;Q8BLH1", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.49", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.49", "type": "external" }, { "id": "3.1.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.31", "type": "external" }, { "id": "1.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.47", "type": "external" }, { "id": "1.1.1.363", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.363", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.20", "type": "external" }, { "id": "1.1.1.179", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.179", "type": "external" }, { "id": "1.1.1.115", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.115", "type": "external" }, { "id": "1.1.1.119", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.119", "type": "external" }, { "id": "1.1.1.120", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.120", "type": "external" } ], "go_molecular_function": "GO:0017057 6-phosphogluconolactonase activity;GO:0030246 carbohydrate binding;GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding;GO:0047934 glucose 1-dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0097305 response to alcohol;GO:0031667 response to nutrient levels;GO:0006098 pentose-phosphate shunt;GO:0009051 pentose-phosphate shunt, oxidative branch", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q8CFX1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5H6-1", "uniprot_id": [ { "id": "FRMD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5H6", "type": "external" } ], "mass": 58583.0, "length": 517, "protein_name": "FERM domain-containing protein 5", "gene_name": "Frmd5", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 5 isoform 2", "refseq_ac": [ { "id": "NP_766261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766261", "type": "external" } ], "gene_names_uniprotkb": "Frmd5", "gene_names_refseq": "1500032A09Rik; A930004K21Rik; Frmd5", "protein_names_uniprotkb": "FERM domain-containing protein 5", "protein_names_refseq": "FERM domain-containing protein 5 isoform 2; FERM domain-containing protein 5", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with eye movement abnormalities and ataxia (Disease Ontology:DOID:0081275)", "pathway": " (mmu:228564)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0R0I9;Q6PFH6;Q8C0K0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0031032 actomyosin structure organization;GO:0030334 regulation of cell migration;GO:2000146 negative regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P5H6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A432-1", "uniprot_id": [ { "id": "CUL4B_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A432", "type": "external" } ], "mass": 110699.0, "length": 970, "protein_name": "Cullin-4B", "gene_name": "Cul4b", "organism": "Mouse", "refseq_name": "cullin-4B", "refseq_ac": [ { "id": "NP_001103612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612", "type": "external" } ], "gene_names_uniprotkb": "Cul4b; Kiaa0695", "gene_names_refseq": "2700050M05Rik; CUL-4B; Cul4b; mKIAA0695", "protein_names_uniprotkb": "Cullin-4B; CUL-4B", "protein_names_refseq": "cullin-4B", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Cabezas type (Disease Ontology:DOID:0060822); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:72584); (R-MMU-110314); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-8951664)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "16052071;17242355;17954973;21183079;21750661;24357321;25428506;30084848;30779550;32782141;34428180;35197566;38689033;38761506;39627609", "class_list": "", "function": "Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35197566). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:35197566). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:35197566). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (By similarity). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (By similarity). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (By similarity). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (By similarity). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (By similarity). Component of the DCX(WDR77) complex, which mediates ubiquitination and degradation of Irgm1 in intestinal cells (PubMed:35197566). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (By similarity). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity). With CUL4A, contributes to ribosome biogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Dynamic role of CUL4B in radiation-induced intestinal injury-regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Enhanced Apc[Min/+] adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells., [RefSeq, PubMed]; Plays a conserved role in the regulation of beta-catenin levels., [RefSeq, PubMed]; The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU30;Q8BSL3;Q8CHD6;Q91YZ7;Q99KS9;Q9CZM5", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0031175 neuron projection development;GO:0006974 DNA damage response;GO:0042254 ribosome biogenesis;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "A2A432-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30999-1", "uniprot_id": [ { "id": "CTND1_MOUSE", "url": "https://www.uniprot.org/uniprot/P30999", "type": "external" } ], "mass": 104925.0, "length": 938, "protein_name": "Catenin delta-1", "gene_name": "Ctnnd1", "organism": "Mouse", "refseq_name": "catenin delta-1 isoform 2", "refseq_ac": [ { "id": "NP_001078917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078917", "type": "external" } ], "gene_names_uniprotkb": "Ctnnd1; Catns; Kiaa0384", "gene_names_refseq": "Catns; Ctnnd1; Ctnnd; P120; mKIAA0384", "protein_names_uniprotkb": "Catenin delta-1; CAS; Cadherin-associated Src substrate; p120 catenin; p120(cas); p120(ctn)", "protein_names_refseq": "CAS; cadherin-associated Src substrate; catenin (cadherin associated protein), delta 1; catenin delta-1 isoform 2; catenin src; p120 catenin; p120(cas); p120(ctn)", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); blepharocheilodontic syndrome 2 (Disease Ontology:DOID:0080346); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:12388); (R-MMU-418990); (R-MMU-5218920); (R-MMU-9762292); (R-MMU-9764561); (R-MMU-9766229); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 8, "publication_count": 44, "publication_id_list": "10.1101/2023.09.13.557529;10207085;12087177;1334250;15138284;15240885;15592455;15817151;17242355;17344476;17947660;18343367;18515860;18630941;19131326;19144319;19267394;20173027;20665223;21183079;21750661;22798526;22872234;23001562;23978243;25153642;25428506;27375112;28528544;30084848;30779550;30899004;31219806;33649389;33972531;34203471;34418053;34428180;34887587;35820727;35996230;37453647;37707499;40684658", "class_list": "", "function": "Delta-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions., [RefSeq, PubMed]; Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:33972531). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSU9;Q80XQ4;Q8CHF8", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0045296 cadherin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:1902532 negative regulation of intracellular signal transduction;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "P30999-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KN9-1", "uniprot_id": [ { "id": "EPN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KN9", "type": "external" } ], "mass": 68513.0, "length": 631, "protein_name": "Clathrin interactor 1", "gene_name": "Clint1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clint1; Enth; Epn4; Epnr; Kiaa0171", "gene_names_refseq": "", "protein_names_uniprotkb": "Clathrin interactor 1; Enthoprotin; Epsin-4; Epsin-related protein; EpsinR", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:216705); (R-MMU-432722)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;17242355;21183079;21750661;22517741;22645316;25428506;25605945;29237092;30059200;30084848;30779550;32782141;32848054;34428180;35822049;36852467;37828378;40885482", "class_list": "", "function": "Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFH4", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0048268 clathrin coat assembly", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q99KN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35803-1", "uniprot_id": [ { "id": "GPM6B_MOUSE", "url": "https://www.uniprot.org/uniprot/P35803", "type": "external" } ], "mass": 36210.0, "length": 328, "protein_name": "Neuronal membrane glycoprotein M6-b", "gene_name": "Gpm6b", "organism": "Mouse", "refseq_name": "neuronal membrane glycoprotein M6-b isoform 1", "refseq_ac": [ { "id": "NP_001171426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171426", "type": "external" } ], "gene_names_uniprotkb": "Gpm6b; M6b", "gene_names_refseq": "Gpm6b; Gpm6; M6B", "protein_names_uniprotkb": "Neuronal membrane glycoprotein M6-b; M6b", "protein_names_refseq": "neuronal membrane glycoprotein M6-b isoform 1; neuronal membrane glycoprotein M6-b", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:14758)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11749036;17114649;18581270;21183079;21750661;29282769;30372567;30899004;32531187;33300544;35243767;35820727;8398137", "class_list": "", "function": "A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting., [RefSeq, PubMed]; FTO regulates ocular angiogenesis via m(6)A-YTHDF2-dependent mechanism., [RefSeq, PubMed]; Findings demonstrate that GPM6B plays a crucial role in SMC differentiation and regulates SMC differentiation through the activation of TGF-beta-Smad2/3 signaling via direct interactions with TbetaRI., [RefSeq, PubMed]; May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake., [UniProtKB, PubMed]; Study identified glycoprotein M6B as a Schwann cell microvilli component of peripheral nodes of Ranvier. Study detected Na(+) channel clusters at heminodes without any associated M6B, indicating that it is not required for initial channel clustering; showed that absence of M6B results in progressive appearance of nodal protrusions of the nodal axolemma, that are often accompanied by the presence of enlarged mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AEG4;Q8R3J6;Q99L14;Q9D4F5;Q9JHG9;Q9JHI1;Q9JHK2;Q9JI62;Q9JI63;Q9JI64;Q9JI65", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0016020 membrane", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0085029 extracellular matrix assembly;GO:0015031 protein transport;GO:0022010 central nervous system myelination;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P35803-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGZ0-1", "uniprot_id": [ { "id": "CHERP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGZ0", "type": "external" } ], "mass": 106169.0, "length": 936, "protein_name": "Calcium homeostasis endoplasmic reticulum protein", "gene_name": "Cherp", "organism": "Mouse", "refseq_name": "calcium homeostasis endoplasmic reticulum protein isoform 1", "refseq_ac": [ { "id": "NP_613051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613051", "type": "external" } ], "gene_names_uniprotkb": "Cherp; Scaf6", "gene_names_refseq": "5730408I11Rik; Cherp; D8Wsu96e; DAN16; Scaf6", "protein_names_uniprotkb": "Calcium homeostasis endoplasmic reticulum protein; SR-related CTD-associated factor 6", "protein_names_refseq": "SR-related CTD associated factor 6; calcium homeostasis endoplasmic reticulum protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27967); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "17242355;17947660;18250455;19144319;19224205;20173027;21183079;21750661;25428507;25605945;34428180;35820727;39627609;40885482", "class_list": "", "function": "Involved in calcium homeostasis, growth and proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K291;Q8VCD2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0033017 sarcoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006396 RNA processing;GO:0008285 negative regulation of cell population proliferation;GO:0006874 intracellular calcium ion homeostasis;GO:0051209 release of sequestered calcium ion into cytosol;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CGZ0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQ73-1", "uniprot_id": [ { "id": "CAND2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQ73", "type": "external" } ], "mass": 135633.0, "length": 1235, "protein_name": "Cullin-associated NEDD8-dissociated protein 2", "gene_name": "Cand2", "organism": "Mouse", "refseq_name": "cullin-associated NEDD8-dissociated protein 2", "refseq_ac": [ { "id": "NP_080234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080234", "type": "external" } ], "gene_names_uniprotkb": "Cand2; Kiaa0667; Tip120b", "gene_names_refseq": "2210404G23Rik; Cand2; Tp120b; mKIAA0667", "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 2; Cullin-associated and neddylation-dissociated protein 2; TBP-interacting protein 120B; TBP-interacting protein of 120 kDa B; p120 CAND2", "protein_names_refseq": "TBP-interacting protein 120B; TBP-interacting protein b; TBP-interacting protein of 120 kDa B; cullin-associated NEDD8-dissociated protein 2; cullin-associated and neddylation-dissociated protein 2; p120 CAND2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:67088)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12207886;25428506;28135057;30084848;30779550;34428180;36288343;37507081;39927985", "class_list": "", "function": "Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHT7", "ec_number_list": [], "go_molecular_function": "GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0010265 SCF complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6ZQ73-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIM3-1", "uniprot_id": [ { "id": "D2HDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIM3", "type": "external" } ], "mass": 58576.0, "length": 535, "protein_name": "D-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "D2hgdh", "organism": "Mouse", "refseq_name": "D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_849213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849213", "type": "external" } ], "gene_names_uniprotkb": "D2hgdh", "gene_names_refseq": "D2hgdh", "protein_names_uniprotkb": "D-2-hydroxyglutarate dehydrogenase, mitochondrial; 1.1.99.39", "protein_names_refseq": "D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform 2 precursor; D-2-hydroxyglutarate dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "D-2-hydroxyglutaric aciduria 1 (Disease Ontology:DOID:0111351); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:98314); (R-MMU-880009)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;23806337", "class_list": "", "function": "Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity)., [UniProtKB, UniProtKB]; Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLL1;Q149H0;Q3TDF5;Q8BU06", "ec_number_list": [ { "id": "1.1.99.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.39", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0071949 FAD binding;GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010043 response to zinc ion;GO:0010042 response to manganese ion;GO:0031648 protein destabilization;GO:0032025 response to cobalt ion;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CIM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UKU4-1", "uniprot_id": [ { "id": "FA83F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UKU4", "type": "external" } ], "mass": 55012.0, "length": 495, "protein_name": "Protein FAM83F", "gene_name": "Fam83f", "organism": "Mouse", "refseq_name": "protein FAM83F isoform 1", "refseq_ac": [ { "id": "NP_666098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666098", "type": "external" } ], "gene_names_uniprotkb": "Fam83f", "gene_names_refseq": "Fam83f; Sack1f", "protein_names_uniprotkb": "Protein FAM83F", "protein_names_refseq": "family with sequence similarity 83, member F; protein FAM83F isoform 1; protein FAM83F", "tax_id": 10090, "disease": "", "pathway": " (mmu:213956)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C578;Q8CDC4;Q8R3Z0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UKU4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PV82-1", "uniprot_id": [ { "id": "FA53A_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PV82", "type": "external" } ], "mass": 43084.0, "length": 402, "protein_name": "Protein FAM53A", "gene_name": "Fam53a", "organism": "Mouse", "refseq_name": "protein FAM53A isoform a", "refseq_ac": [ { "id": "NP_848477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848477", "type": "external" } ], "gene_names_uniprotkb": "Fam53a; Dntnp", "gene_names_refseq": "2410018C17Rik; 5430419M09Rik; Dntnp; Fam53a", "protein_names_uniprotkb": "Protein FAM53A; Dorsal neural-tube nuclear protein", "protein_names_refseq": "dorsal neural-tube nuclear protein; protein FAM53A isoform a; protein FAM53A", "tax_id": 10090, "disease": "", "pathway": " (mmu:74504)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11984880;21183079;21750661;25428506", "class_list": "", "function": "May play an important role in neural development; the dorsomedial roof of the third ventricle., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2K2;Q8R5K1;Q91VG1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PV82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WM6-1", "uniprot_id": [ { "id": "EVA1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WM6", "type": "external" } ], "mass": 17810.0, "length": 156, "protein_name": "Protein eva-1 homolog A", "gene_name": "Eva1a", "organism": "Mouse", "refseq_name": "protein eva-1 homolog A", "refseq_ac": [ { "id": "NP_663545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663545", "type": "external" } ], "gene_names_uniprotkb": "Eva1a; Fam176a; Tmem166", "gene_names_refseq": "Eva1a; Fam176a; Tmem166", "protein_names_uniprotkb": "Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166", "protein_names_refseq": "eva-1 homolog A; family with sequence similarity 176, member A; protein FAM176A; protein eva-1 homolog A; transmembrane protein 166", "tax_id": 10090, "disease": "", "pathway": " (mmu:232146)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21750661;26905199;28044434;28151473;31977009;34428180;36794585;37611898", "class_list": "", "function": "ATP synthesis, oxidative phosphorylation, and the TCA cycle, are involved in the EVA1A regulatory network.EVA1A plays an important role in neuronal differentiation., [RefSeq, PubMed]; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis., [UniProtKB]; EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Erratum:[Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):e230. doi: 10.1161/ATV.0000000000000163. PMID: 37224275], [RefSeq, PubMed]; EVA1A deletion results in defective self-renewal and differentiation of NSCs. EVA1A modulates autophagy through the PIK3CA/AKT-mTOR pathway., [RefSeq, PubMed]; Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b., [RefSeq, PubMed]; Eva1a improves cardiac function. Publication Status: Online-Only, [RefSeq, PubMed]; Microglia Autophagy Mediated by TMEM166 Promotes Ischemic Stroke Secondary to Carotid Artery Stenosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X936", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0007507 heart development;GO:0006915 apoptotic process;GO:0030324 lung development;GO:0006914 autophagy;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91WM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14404-2", "uniprot_id": [ { "id": "MECOM_MOUSE", "url": "https://www.uniprot.org/uniprot/P14404", "type": "external" } ], "mass": 138100.0, "length": 1232, "protein_name": "Histone-lysine N-methyltransferase MECOM", "gene_name": "Mecom", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase MECOM isoform 2", "refseq_ac": [ { "id": "NP_067417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067417", "type": "external" } ], "gene_names_uniprotkb": "Mecom; Evi1; Mds1; Prdm3", "gene_names_refseq": "D630039M04Rik; Evi-1; Evi1; Jbo; Mds1-Evi1; Mds1; Mds; Mecom; Prdm3; Znfpr1b1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase MECOM; 2.1.1.367; EVI-1; Ecotropic virus integration site 1 protein; MDS1 and EVI1 complex locus protein; Myelodysplasia syndrome 1 protein homolog", "protein_names_refseq": "MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; ecotropic viral integration site 1; ecotropic virus integration site 1 protein; histone-lysine N-methyltransferase MECOM isoform 2; histone-lysine N-methyltransferase MECOM; myelodysplasia syndrome 1 protein homolog", "tax_id": 10090, "disease": "myeloid neoplasm (Disease Ontology:DOID:0070004); otitis media (Disease Ontology:DOID:10754)", "pathway": " (mmu:14013); (R-MMU-3214841); (R-MMU-8943724)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15889140;18619962;19767769;2106070;21183079;22939622;2842066;34428180;35820727;9256345;9837768", "class_list": "", "function": "Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622)., [UniProtKB, PubMed]; Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3UWT0;Q9Z1L8", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0098727 maintenance of cell number;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P14404-2", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34152-3", "uniprot_id": [ { "id": "FAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P34152", "type": "external" } ], "mass": 119243.0, "length": 1052, "protein_name": "Focal adhesion kinase 1", "gene_name": "Ptk2", "organism": "Mouse", "refseq_name": "focal adhesion kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_032008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032008", "type": "external" } ], "gene_names_uniprotkb": "Ptk2; Fadk; Fak1; Fak; Kiaa4203", "gene_names_refseq": "FADK 1; FAK; FRNK; Fadk; Ptk2; p125FAK", "protein_names_uniprotkb": "Focal adhesion kinase 1; 2.7.10.2; FADK 1; FRNK; Focal adhesion kinase-related nonkinase; Protein-tyrosine kinase 2; p125FAK; pp125FAK", "protein_names_refseq": "focal adhesion kinase 1 isoform 1; focal adhesion kinase 1; focal adhesion kinase-related nonkinase; focal ashension kinase 1; pp125FAK; protein-tyrosine kinase 2", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); leiomyoma (Disease Ontology:DOID:127); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); cervix carcinoma (Disease Ontology:DOID:2893); ischemia (Disease Ontology:DOID:326); lung squamous cell carcinoma (Disease Ontology:DOID:3907); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); uremia (Disease Ontology:DOID:4676); lung small cell carcinoma (Disease Ontology:DOID:5409); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14083)", "pathway_count": 1, "publication_count": 211, "publication_id_list": "10373530;10430888;10497197;10806474;10891511;10896938;10931187;11278462;11279163;11314030;11369769;11420674;11468287;11683393;11799401;11821402;11839767;11927607;12083796;12087088;12221124;12464388;12515828;12674328;12692126;12702722;12748308;12941275;14500712;14500722;14676198;15123632;15174091;1528852;15302877;15494733;15494734;15561106;15592455;15845548;15967814;16000375;16132110;16293639;16337627;16391003;16682956;16828471;16889663;16972260;17022972;17093062;17242355;17289681;17303567;17417603;17976369;18034455;18206965;18356303;19000654;19098120;19147981;19372463;19473962;19596799;19776009;19917775;20234191;20234193;20530207;20552554;20737513;20886051;21068464;21183079;21289086;21347357;21482413;21535874;21544092;21823119;21921419;22056317;22105351;22128142;22204307;22279574;22285464;22322421;22614008;22685302;22872234;22887049;22919583;22974528;23027128;23028449;23571270;23613946;23637231;23642017;23693126;23695213;23716717;23799510;23824717;24108461;24124594;24142503;24169345;24416452;24446483;24755674;24888687;24899686;25059660;25063025;25100946;25118939;25242698;25280866;25319025;25377086;25428506;25609658;25612833;25692763;25938342;26068982;26194913;26247733;26340932;26378057;26455318;26517238;26908052;27009091;27176481;27306643;27374103;27463003;27677358;27708220;27893716;27905395;27994061;28108732;28165007;28255537;28331230;28383553;28416479;28424421;28444899;28600496;28639351;28701345;28782937;28915654;29209901;29238610;29303405;29351412;29416084;29420611;29472531;29528115;30001432;30065303;30084848;30250269;30717276;31215459;31219806;31604999;31831012;31882770;31942012;32025610;32144580;32396631;32493400;32612176;32642407;32655375;32899862;33250856;33643917;33730293;33917849;34240802;34428180;35325397;35455022;36210013;36438565;7478517;7479864;7529876;7622520;7997267;8816475;8824286;9032297;9148935;9353341;9422762;9461600;9756887;9790958", "class_list": "", "function": "Does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription (By similarity)., [UniProtKB, UniProtKB]; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G protein-coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:25059660). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Organization and post-transcriptional processing of focal adhesion kinase gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08578;Q5DTH7;Q8C513;Q8CFH7;Q8CHM2;Q8K2S0;Q9DAW3", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005178 integrin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0046621 negative regulation of organ growth;GO:0051893 regulation of focal adhesion assembly;GO:0060252 positive regulation of glial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 21.2, "record_id": "P34152-3", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97481-1", "uniprot_id": [ { "id": "EPAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97481", "type": "external" } ], "mass": 96712.0, "length": 874, "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "Epas1", "organism": "Mouse", "refseq_name": "endothelial PAS domain-containing protein 1", "refseq_ac": [ { "id": "NP_034267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034267", "type": "external" } ], "gene_names_uniprotkb": "Epas1; Hif2a", "gene_names_refseq": "Epas1; HIF-2alpha; HIF2A; HLF; HRF; MOP2; bHLHe73", "protein_names_uniprotkb": "Endothelial PAS domain-containing protein 1; EPAS-1; HIF-1-alpha-like factor; HIF-2-alpha; HIF-related factor; HIF2-alpha; HLF; HRF; Hypoxia-inducible factor 2-alpha; mHLF", "protein_names_refseq": "EPAS-1; HIF-1-alpha-like factor; HIF-2-alpha; HIF-related factor; HIF1 alpha-like factor; HIF2-alpha; HLF (HIF1alpha-like factor); Hif like protein; endothelial PAS domain-containing protein 1; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2-alpha; mHLF", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); familial erythrocytosis 4 (Disease Ontology:DOID:0080339); pre-eclampsia (Disease Ontology:DOID:10591); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cancer (Disease Ontology:DOID:162); acute kidney failure (Disease Ontology:DOID:3021); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); polycythemia (Disease Ontology:DOID:8432); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13819); (R-MMU-1234158); (R-MMU-1234174); (R-MMU-1234176); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10704462;11823643;11983697;12080085;18299400;19224205;20173027;21546903;25428507;26245371;27802388;30084848;30779550;31219806;34428180;35820727;36210013;37828378;9000051;9113979;9178256", "class_list": "", "function": "Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08787;O55046", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97481-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNV1-1", "uniprot_id": [ { "id": "TLC3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNV1", "type": "external" } ], "mass": 30778.0, "length": 275, "protein_name": "Ceramide synthase", "gene_name": "Tlcd3b", "organism": "Mouse", "refseq_name": "ceramide synthase isoform 3", "refseq_ac": [ { "id": "NP_001139819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139819", "type": "external" } ], "gene_names_uniprotkb": "Tlcd3b; Fam57b", "gene_names_refseq": "1500016O10Rik; A330104J06Rik; Fam57b; Tlcd3b", "protein_names_uniprotkb": "Ceramide synthase; 2.3.1.-; Protein FAM57B; TLC domain-containing protein 3B", "protein_names_refseq": "TLC domain-containing protein 3B; ceramide synthase isoform 3; ceramide synthase; family with sequence similarity 57, member B; protein FAM57B", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cone-rod dystrophy 22 (Disease Ontology:DOID:0081448)", "pathway": " (mmu:68952)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23275342;33077892", "class_list": "", "function": "Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis., [UniProtKB, PubMed]; PPARgamma regulates Fam57b transcription during the adipogenesis of ST2 cells Erratum:[J Biol Chem. 2020 Apr 10;295(15):5176. doi: 10.1074/jbc.AAC120.013475. PMID: 32277067], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2R2;Q561N3;Q9CW26", "ec_number_list": [ { "id": "2.3.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.24", "type": "external" }, { "id": "2.3.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.299", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.291", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.291", "type": "external" }, { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" } ], "go_molecular_function": "GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0055088 lipid homeostasis;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGR5-1", "uniprot_id": [ { "id": "FA53B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGR5", "type": "external" } ], "mass": 45939.0, "length": 422, "protein_name": "Protein FAM53B", "gene_name": "Fam53b", "organism": "Mouse", "refseq_name": "protein FAM53B isoform b", "refseq_ac": [ { "id": "NP_001334559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334559", "type": "external" } ], "gene_names_uniprotkb": "Fam53b", "gene_names_refseq": "A930008G19Rik; Fam53b; mKIAA0140", "protein_names_uniprotkb": "Protein FAM53B", "protein_names_refseq": "protein FAM53B isoform b; protein FAM53B", "tax_id": 10090, "disease": "", "pathway": " (mmu:77938)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;25183871", "class_list": "", "function": "Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization., [UniProtKB, UniProtKB]; Simplet/Fam53b is required for Wnt signal transduction by regulating beta-catenin nuclear localization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGW1;Q8BI13", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3F2-1", "uniprot_id": [ { "id": "F120C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3F2", "type": "external" } ], "mass": 119718.0, "length": 1091, "protein_name": "Constitutive coactivator of PPAR-gamma-like protein 2", "gene_name": "Fam120c", "organism": "Mouse", "refseq_name": "constitutive coactivator of PPAR-gamma-like protein 2", "refseq_ac": [ { "id": "NP_932773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932773", "type": "external" } ], "gene_names_uniprotkb": "Fam120c; ORF34", "gene_names_refseq": "D930001I21Rik; Fam120c; ORF34", "protein_names_uniprotkb": "Constitutive coactivator of PPAR-gamma-like protein 2; Protein FAM120C", "protein_names_refseq": "constitutive coactivator of PPAR-gamma-like protein 2; family with sequence similarity 120C", "tax_id": 10090, "disease": "", "pathway": " (mmu:207375)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14585507;24129315", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0F6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C3F2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0W0-1", "uniprot_id": [ { "id": "EPIPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0W0", "type": "external" } ], "mass": 724646.0, "length": 6548, "protein_name": "Epiplakin", "gene_name": "Eppk1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eppk1; EPPK", "gene_names_refseq": "", "protein_names_uniprotkb": "Epiplakin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:223650)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12791695;16382146;18285451;20926261;21750661;23599337;25232867;25428506;25617501;29237092;30084848;31219806;34428180;35820727;36210013;37453647;37828378", "class_list": "", "function": "Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:16382146, PubMed:18285451, PubMed:20926261, PubMed:23599337, PubMed:25232867, PubMed:25617501). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:16382146, PubMed:20926261). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity (PubMed:23599337). In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption (PubMed:18285451). During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (PubMed:25232867, PubMed:25617501)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0005198 structural molecule activity;GO:0019215 intermediate filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0030336 negative regulation of cell migration;GO:0050680 negative regulation of epithelial cell proliferation;GO:0007010 cytoskeleton organization;GO:0061045 negative regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R0W0-1", "record_type": "protein", "filter_code": "0000000.1000101.000100.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W69-1", "uniprot_id": [ { "id": "EPN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W69", "type": "external" } ], "mass": 68240.0, "length": 636, "protein_name": "Epsin-3", "gene_name": "Epn3", "organism": "Mouse", "refseq_name": "epsin-3 isoform 1", "refseq_ac": [ { "id": "NP_082260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082260", "type": "external" } ], "gene_names_uniprotkb": "Epn3", "gene_names_refseq": "2310022G12Rik; Epn3", "protein_names_uniprotkb": "Epsin-3; EPS-15-interacting protein 3", "protein_names_refseq": "EPS-15-interacting protein 3; epsin-3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71889)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21115825;21183079;25122462;25428506;26495903;30084848;31599954;34428180", "class_list": "", "function": "Data suggest that epsin 3 cooperates with other bilayer binding proteins with curvature sensing/generating properties in the specialized traffic and membrane remodeling processes typical of gastric parietal cells, [RefSeq, PubMed]; Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV55", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:1990175 EH domain binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91W69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LC5-1", "uniprot_id": [ { "id": "ETFA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LC5", "type": "external" } ], "mass": 35009.0, "length": 333, "protein_name": "Electron transfer flavoprotein subunit alpha, mitochondrial", "gene_name": "Etfa", "organism": "Mouse", "refseq_name": "electron transfer flavoprotein subunit alpha, mitochondrial", "refseq_ac": [ { "id": "NP_663590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663590", "type": "external" } ], "gene_names_uniprotkb": "Etfa", "gene_names_refseq": "2010200I21Rik; D9Ertd394e; Etfa", "protein_names_uniprotkb": "Electron transfer flavoprotein subunit alpha, mitochondrial; Alpha-ETF", "protein_names_refseq": "Alpha-ETF; electron transfer flavoprotein subunit alpha, mitochondrial", "tax_id": 10090, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (mmu:110842); (R-MMU-611105)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "17322886;21183079;23576753;23806337;25605945;30084848;31112734;31941714;32152506;33300544;34428180;35820727;36288343;37453647;37507081;39927985", "class_list": "", "function": "Hepatic neddylation also enhances ETFA and ETFB expression in adult mice and prevents fasting-induced steatosis and mortality., [RefSeq, PubMed]; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THD7;Q3V000;Q4V9X5;Q8BMD3;Q8BMU7", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0017133 mitochondrial electron transfer flavoprotein complex;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045251 electron transfer flavoprotein complex", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904 respiratory electron transport chain;GO:0009063 amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q99LC5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70589-1", "uniprot_id": [ { "id": "CSKP_MOUSE", "url": "https://www.uniprot.org/uniprot/O70589", "type": "external" } ], "mass": 105109.0, "length": 926, "protein_name": "Peripheral plasma membrane protein CASK", "gene_name": "Cask", "organism": "Mouse", "refseq_name": "peripheral plasma membrane protein CASK isoform 1", "refseq_ac": [ { "id": "NP_001271432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271432", "type": "external" } ], "gene_names_uniprotkb": "Cask; Lin-2", "gene_names_refseq": "Cask; DXPri1; DXRib1; LIN-2; Pals3; mLin-2", "protein_names_uniprotkb": "Peripheral plasma membrane protein CASK; 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase", "protein_names_refseq": "calcium/calmodulin-dependent serine protein kinase (MAGUK family); peripheral plasma membrane protein CASK isoform 1; peripheral plasma membrane protein CASK", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); FG syndrome (Disease Ontology:DOID:14711)", "pathway": " (mmu:12361); (R-MMU-212676); (R-MMU-6794361)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10749215;10846156;15066269;15863617;21183079;21750661;22337881;25385611;33318489;38670634;9787075", "class_list": "", "function": "Genetic evidence for splicing-dependent structural and functional plasticity in CASK protein. Publication Status: Online-Only, [RefSeq, PubMed]; Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (By similarity). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ADP8;A2ADP9;A2ADQ4;O70588;Q3UW92", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0015031 protein transport;GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70589-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K368-1", "uniprot_id": [ { "id": "FANCI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K368", "type": "external" } ], "mass": 149326.0, "length": 1330, "protein_name": "Fanconi anemia group I protein homolog", "gene_name": "Fanci", "organism": "Mouse", "refseq_name": "Fanconi anemia group I protein homolog", "refseq_ac": [ { "id": "NP_666058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666058", "type": "external" } ], "gene_names_uniprotkb": "Fanci", "gene_names_refseq": "Fanci", "protein_names_uniprotkb": "Fanconi anemia group I protein homolog; Protein FACI", "protein_names_refseq": "Fanconi anemia group I protein homolog", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group I (Disease Ontology:DOID:0111091); Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (mmu:208836); (R-MMU-6783310)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17412408;17460694;21750661;21764741;25428506;31219578;31219806;34373449;40021952", "class_list": "", "function": "Crystal structure of FANCI-FANCD2(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link, [RefSeq, PubMed]; FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation. Erratum:[Cell Death Dis. 2021 Aug 26;12(9):808. doi: 10.1038/s41419-021-04096-7. PMID: 34446697] Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). Participates in S phase and G2 phase checkpoint activation upon DNA damage (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Studies indicate common and distinct functions of Fanconi anemia complementation group I (FANCI) and Fanconi Anemia Group D2 Protein (FANCD2) during mouse development, meiotic recombination and hematopoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUE9;Q8R3G8", "ec_number_list": [], "go_molecular_function": "GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990391 DNA repair complex", "go_biological_process": "GO:0006281 DNA repair;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K368-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z265-1", "uniprot_id": [ { "id": "CHK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z265", "type": "external" } ], "mass": 61088.0, "length": 546, "protein_name": "Serine/threonine-protein kinase Chk2", "gene_name": "Chek2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Chk2 isoform 1", "refseq_ac": [ { "id": "NP_057890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057890", "type": "external" } ], "gene_names_uniprotkb": "Chek2; Chk2; Rad53", "gene_names_refseq": "CHK2; Cds1; Chek2; HUCDS1; Rad53", "protein_names_uniprotkb": "Serine/threonine-protein kinase Chk2; 2.7.11.1; CHK2 checkpoint homolog; Checkpoint kinase 2", "protein_names_refseq": "CHK2 checkpoint homolog; Cds1 homolog; Rad53 homolog; serine/threonine-protein kinase Chk2 isoform 1; serine/threonine-protein kinase Chk2", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); Li-Fraumeni syndrome 2 (Disease Ontology:DOID:0111504); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); male breast cancer (Disease Ontology:DOID:1614); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:50883); (R-MMU-5693565); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-69473); (R-MMU-69541); (R-MMU-69601); (R-MMU-75035)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "12097646;12192050;12356735;17431115;21183079;21750661;23667485;23839489;24069304;25619829;27982046;29725001;30084848;34428180;9836640", "class_list": "", "function": "Chk2 regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner, [RefSeq, PubMed]; Results show that Chk2 plays a critical role in p53 function in response to IR by regulating its transcriptional activity as well as its stability, [RefSeq, PubMed]; Role of Chk2 in p53-dependent apoptotic response, [RefSeq, PubMed]; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (By similarity). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-56' leading to positive regulation of the autophagosme assembly (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016605 PML body", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0000045 autophagosome assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z265-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LD4-1", "uniprot_id": [ { "id": "CSN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LD4", "type": "external" } ], "mass": 53442.0, "length": 471, "protein_name": "COP9 signalosome complex subunit 1", "gene_name": "Gps1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gps1; Cops1; Csn1", "gene_names_refseq": "", "protein_names_uniprotkb": "COP9 signalosome complex subunit 1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; SGN1; Signalosome subunit 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664); (R-MMU-9013422)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "16476741;17242355;17276034;17525332;21183079;21750661;22872234;31219806;34428180;36210013;37507081;9707402", "class_list": "", "function": "Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZT1;Q8C2J7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99LD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62219-1", "uniprot_id": [ { "id": "TGFI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62219", "type": "external" } ], "mass": 50101.0, "length": 461, "protein_name": "Transforming growth factor beta-1-induced transcript 1 protein", "gene_name": "Tgfb1i1", "organism": "Mouse", "refseq_name": "transforming growth factor beta-1-induced transcript 1 protein isoform a", "refseq_ac": [ { "id": "NP_001276479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276479", "type": "external" } ], "gene_names_uniprotkb": "Tgfb1i1; Ara55", "gene_names_refseq": "ARA55; Hic5; TSC-5; Tgfb1i1; hic-5", "protein_names_uniprotkb": "Transforming growth factor beta-1-induced transcript 1 protein; Androgen receptor-associated protein of 55 kDa; Hic-5; Hydrogen peroxide-inducible clone 5 protein; TGF beta-stimulated clone 5; TSC-5", "protein_names_refseq": "TGF beta-stimulated clone 5; androgen receptor-associated protein of 55 kDa; hydrogen peroxide-inducible clone 5 protein; transforming growth factor beta-1-induced transcript 1 protein isoform a; transforming growth factor beta-1-induced transcript 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21804)", "pathway_count": 1, "publication_count": 39, "publication_id_list": "10092676;10330411;10649439;10831843;10848625;11134073;11437454;11463817;11546764;11779876;11805099;11937715;12153727;12177201;12631731;14755691;15687259;15713747;16183059;16219310;16219691;16291758;16624805;16737959;17166536;17233630;17299801;21183079;21750661;25428506;28528544;31219806;34428180;38237846;7929412;9422762;9722648;9756887;9858471", "class_list": "", "function": "Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Hic-5 regulates extracellular matrix-associated gene expression and cytokine secretion in cancer associated fibroblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3YBY7;Q3YBY8;Q3YBZ0;Q3YBZ1;Q3YBZ3;Q3YBZ4;Q3YBZ5;Q3YBZ6", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0050681 nuclear androgen receptor binding;GO:0048495 Roundabout binding;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0016363 nuclear matrix", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0016331 morphogenesis of embryonic epithelium;GO:0034446 substrate adhesion-dependent cell spreading;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q62219-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97366-1", "uniprot_id": [ { "id": "EVI5_MOUSE", "url": "https://www.uniprot.org/uniprot/P97366", "type": "external" } ], "mass": 92943.0, "length": 809, "protein_name": "Ecotropic viral integration site 5 protein", "gene_name": "Evi5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Evi5", "gene_names_refseq": "", "protein_names_uniprotkb": "Ecotropic viral integration site 5 protein; EVI-5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;34428180;9070650", "class_list": "", "function": "Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPQ1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0051301 cell division;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97366-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70405-1", "uniprot_id": [ { "id": "ULK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70405", "type": "external" } ], "mass": 112463.0, "length": 1051, "protein_name": "Serine/threonine-protein kinase ULK1", "gene_name": "Ulk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase ULK1 isoform 2", "refseq_ac": [ { "id": "NP_033495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033495", "type": "external" } ], "gene_names_uniprotkb": "Ulk1", "gene_names_refseq": "Ulk1; Unc51.1; mKIAA0722", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK1; 2.7.11.1; Serine/threonine-protein kinase Unc51.1; Unc-51-like kinase 1", "protein_names_refseq": "serine/threonine-protein kinase ULK1 isoform 2; serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1", "tax_id": 10090, "disease": "mucositis (Disease Ontology:DOID:0080178); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)", "pathway": " (mmu:22241); (R-MMU-1632852); (R-MMU-5357905); (R-MMU-8854214); (R-MMU-8876198); (R-MMU-8934903)", "pathway_count": 6, "publication_count": 70, "publication_id_list": "10624947;19258318;21183079;21205641;21258367;21460634;21750661;22539723;23964069;24187137;24389528;24449471;24732703;24988326;25040165;25071026;25723488;25780086;25905437;25991723;26039451;26487002;26556533;26869683;27119351;27246695;27314664;27343428;27387347;27464336;27617292;27887947;28492544;28674405;28903979;28916822;29348566;29540819;29732320;30022064;30031227;30112966;30544824;30729040;31005723;31219806;31225455;31261758;31469345;31594991;31865844;32207633;32273498;32299471;32512189;32782141;32850000;32987187;33128669;33459523;33562139;33800526;34074127;34428180;36210013;36852467;38056619;39213022;40885482;9600096", "class_list": "", "function": "Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth in preclinical models of lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:10624947, PubMed:19258318, PubMed:21205641, PubMed:21258367, PubMed:21460634, PubMed:25040165, PubMed:25723488). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:10624947, PubMed:19258318, PubMed:21205641, PubMed:21258367, PubMed:21460634, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21205641, PubMed:21258367). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:19258318). Plays a role early in neuronal differentiation and is required for granule cell axon formation (By similarity). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:25723488). Phosphorylates FLCN, promoting autophagy (By similarity). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (By similarity). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Serine/threonine-protein kinase involved in autophagy in response to starvation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGB2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0021933 radial glia guided migration of cerebellar granule cell;GO:0000045 autophagosome assembly;GO:0007409 axonogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 7.5, "record_id": "O70405-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97314-1", "uniprot_id": [ { "id": "CSRP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97314", "type": "external" } ], "mass": 20926.0, "length": 193, "protein_name": "Cysteine and glycine-rich protein 2", "gene_name": "Csrp2", "organism": "Mouse", "refseq_name": "cysteine and glycine-rich protein 2", "refseq_ac": [ { "id": "NP_031818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031818", "type": "external" } ], "gene_names_uniprotkb": "Csrp2; Dlp1", "gene_names_refseq": "Crp2; Csrp2; SmLim", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 2; CRP2; Cysteine-rich protein 2; DLP-1; Double LIM protein 1", "protein_names_refseq": "DLP-1; cysteine and glycine-rich protein 2; cysteine-rich protein 2; double LIM protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13008)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11748300;18258855;21750661;23806337;23975851;25605945;26251235;28528544;34428180;36210013;38041233", "class_list": "", "function": "CRP2 sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration., [RefSeq, PubMed]; Could play a role in neuronal development., [UniProtKB, UniProtKB]; Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity)., [UniProtKB]; Evolutionarily conserved Lin-11, Isl-1, Mac-3 (LIM) domain protein that have been implicated in cell differentiation., [RefSeq, PubMed]; It is a non-Hsp gene, which is essential for HSF1-mediated maintenance of whole body homeostasis., [RefSeq, PubMed]; TGF-beta signaling promotes desmoid tumor formation via CSRP2 upregulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZG5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0045214 sarcomere organization;GO:0060537 muscle tissue development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97314-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LM2-1", "uniprot_id": [ { "id": "CK5P3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LM2", "type": "external" } ], "mass": 56991.0, "length": 503, "protein_name": "CDK5 regulatory subunit-associated protein 3", "gene_name": "Cdk5rap3", "organism": "Mouse", "refseq_name": "CDK5 regulatory subunit-associated protein 3 isoform 1", "refseq_ac": [ { "id": "NP_084524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084524", "type": "external" } ], "gene_names_uniprotkb": "Cdk5rap3", "gene_names_refseq": "1810007E24Rik; C53; Cdk5rap3; HSF-27; IC53; LZAP; MST016", "protein_names_uniprotkb": "CDK5 regulatory subunit-associated protein 3", "protein_names_refseq": "CDK5 regulatory subunit-associated protein 3 isoform 1", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709)", "pathway": " (mmu:80280)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16012757;21494687;21750661;30635284;33182370;33504792;35509151", "class_list": "", "function": "CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury. Publication Status: Online-Only, [RefSeq, PubMed]; CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth., [RefSeq, PubMed]; Cdk5rap3 is essential for intestinal Paneth cell development and maintenance. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that C53 might play a role in regulating neuronal proliferation, migration and/or differentiation in embryonic development., [RefSeq, PubMed]; Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy) (PubMed:30635284). As part of the UREL complex, plays a key role in ribosome recycling by promoting mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (By similarity). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Within the UREL complex, CDK5RAP3 acts as a substrate adapter that constrains UFL1 ligase activity to mono-ufmylate RPL26/uL24 at 'Lys-134' (By similarity). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Also acts as a regulator of transcription: negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (PubMed:30635284)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE41", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051019 mitogen-activated protein kinase binding;GO:0044877 protein-containing complex binding;GO:0051059 NF-kappaB binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0060318 definitive erythrocyte differentiation;GO:0001889 liver development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99LM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UBX0-1", "uniprot_id": [ { "id": "TM109_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UBX0", "type": "external" } ], "mass": 26306.0, "length": 243, "protein_name": "Voltage-gated monoatomic cation channel TMEM109", "gene_name": "Tmem109", "organism": "Mouse", "refseq_name": "voltage-gated monoatomic cation channel TMEM109 precursor", "refseq_ac": [ { "id": "NP_598903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598903", "type": "external" } ], "gene_names_uniprotkb": "Tmem109", "gene_names_refseq": "1110006I15Rik; Tmem109", "protein_names_uniprotkb": "Voltage-gated monoatomic cation channel TMEM109; Mg23; Mitsugumin-23; Transmembrane protein 109", "protein_names_refseq": "mg23; mitsugumin-23; mitsugumin23; voltage-gated monoatomic cation channel TMEM109 precursor; voltage-gated monoatomic cation channel TMEM109", "tax_id": 10090, "disease": "", "pathway": " (mmu:68539)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20060811;21750661;22645316;23542032;28630041;34428180;37828378;38223925", "class_list": "", "function": "Ca[2+] storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 23., [RefSeq, PubMed]; Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23), [RefSeq, PubMed]; Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (PubMed:20060811)., [UniProtKB, UniProtKB, PubMed]; MG23 is an essential component of ER-generated lethal signals provoked upon DNA damage, specifying cell fate under pathophysiological conditions., [RefSeq, PubMed]; MG23 plays a protective role against UVC by accumulating alphaBC in the close vicinity of the ER, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R006", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0033017 sarcoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043069 negative regulation of programmed cell death;GO:0071480 cellular response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UBX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57680-1", "uniprot_id": [ { "id": "EVC_MOUSE", "url": "https://www.uniprot.org/uniprot/P57680", "type": "external" } ], "mass": 113003.0, "length": 1005, "protein_name": "EvC complex member EVC", "gene_name": "Evc", "organism": "Mouse", "refseq_name": "evC complex member EVC isoform 1", "refseq_ac": [ { "id": "NP_067267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067267", "type": "external" } ], "gene_names_uniprotkb": "Evc", "gene_names_refseq": "Evc", "protein_names_uniprotkb": "EvC complex member EVC; Ellis-van Creveld syndrome protein homolog", "protein_names_refseq": "Ellis van Creveld gene homolog; Ellis van Creveld gene syndrome; EvC protein (Ellis-van Creveld syndrome); ellis-van Creveld syndrome protein homolog; evC complex member EVC isoform 1; evC complex member EVC", "tax_id": 10090, "disease": "Weyers acrofacial dysostosis (Disease Ontology:DOID:0111571); Ellis-Van Creveld syndrome (Disease Ontology:DOID:12714); ventricular septal defect (Disease Ontology:DOID:1657)", "pathway": " (mmu:59056); (R-MMU-5632684)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10700184;17660199;19251731;21356043;21750661;24582806;34418053", "class_list": "", "function": "Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:17660199, PubMed:24582806). Involved in endochondral growth and skeletal development (PubMed:17660199)., [UniProtKB, PubMed, PubMed]; EVC and LBN protein colocalize at the tip of the primary atrial septum during murine cardiac development., [RefSeq, PubMed]; Evc is an intracellular component of the hedgehog signal transduction pathway that is required for normal transcriptional activation of Ihh target genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0060170 ciliary membrane;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007224 smoothened signaling pathway;GO:0051216 cartilage development;GO:0003416 endochondral bone growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P57680-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35927-1", "uniprot_id": [ { "id": "CTND2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35927", "type": "external" } ], "mass": 135000.0, "length": 1247, "protein_name": "Catenin delta-2", "gene_name": "Ctnnd2", "organism": "Mouse", "refseq_name": "catenin delta-2 isoform 1", "refseq_ac": [ { "id": "NP_032755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032755", "type": "external" } ], "gene_names_uniprotkb": "Ctnnd2; Catnd2; Nprap", "gene_names_refseq": "Catnd2; Ctnnd2; Nprap; neurojugin", "protein_names_uniprotkb": "Catenin delta-2; NPRAP; Neural plakophilin-related ARM-repeat protein; Neurojungin", "protein_names_refseq": "catenin (cadherin associated protein), delta 2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); catenin delta-2 isoform 1; neural plakophilin-related arm-repeat protein; neurojungin", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); major depressive disorder (Disease Ontology:DOID:1470); anxiety disorder (Disease Ontology:DOID:2030); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18163)", "pathway_count": 1, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;10626844;10753311;15282317;15345747;16452087;16452088;17993462;18034455;19458039;19706605;20623542;21183079;21750661;22517741;22645316;22826440;24129315;25807484;26192747;30084848;30221043;32782141;32848054;33300544;34428180;34455763;34678516;35822049;36210013;36852467;37226399;40021952;40885482;9342840;9971746", "class_list": "", "function": "Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice., [RefSeq, PubMed]; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:17993462, PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (PubMed:15282317)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 34, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 34, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 34, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 36, "binding_glycan_count": 0, "secondary_ac_list": "B2RR80", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007612 learning;GO:0050808 synapse organization;GO:0048167 regulation of synaptic plasticity;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "O35927-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08582-1", "uniprot_id": [ { "id": "GTPB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08582", "type": "external" } ], "mass": 72301.0, "length": 668, "protein_name": "GTP-binding protein 1", "gene_name": "Gtpbp1", "organism": "Mouse", "refseq_name": "GTP-binding protein 1", "refseq_ac": [ { "id": "NP_038846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038846", "type": "external" } ], "gene_names_uniprotkb": "Gtpbp1; Gtpbp", "gene_names_refseq": "GP-1; Gtpbp1; Gtpbp", "protein_names_uniprotkb": "GTP-binding protein 1; 3.6.5.3; G protein 1; GP-1; GP1", "protein_names_refseq": "G-protein 1; GP1; GTP-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14904)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10938096;11180106;11911820;15345747;17242355;18250455;21183079;21515746;21750661;25428506;25428507;25605945;28135057;28528544;30084848;30779550;32161037;34428180;37828378;40997131;9070279", "class_list": "", "function": "Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase that plays a role in the elongation phase of protein synthesis by forming ternary complexes with GTP and aminoacyl-transfer RNAs (aa-tRNAs), and delivering aa-tRNAs to the ribosomal A site in a GTP-dependent manner. Is also able to deliver deacylated tRNA to the A site. Additionally, it is involved in RNA quality control; after GTP hydrolysis, which is not immediately followed by rapid peptide bond formation, GTPBP1 likely retains aa-tRNA in the A site and promotes exosomal degradation of faulty mRNAs engaged in 80S elongation complexes (By similarity). Plays a role in the regulation of circadian mRNA stability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD96;Q3UGW6;Q545R1;Q80ZY5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0003746 translation elongation factor activity;GO:1904678 alpha-aminoacyl-tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071025 RNA surveillance;GO:0046039 GTP metabolic process;GO:0061014 positive regulation of mRNA catabolic process;GO:0006414 translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O08582-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52194-1", "uniprot_id": [ { "id": "CLGN_MOUSE", "url": "https://www.uniprot.org/uniprot/P52194", "type": "external" } ], "mass": 69431.0, "length": 611, "protein_name": "Calmegin", "gene_name": "Clgn", "organism": "Mouse", "refseq_name": "calmegin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001316556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316556", "type": "external" } ], "gene_names_uniprotkb": "Clgn; Meg1", "gene_names_refseq": "4930459O04Rik; A2/6; Clgn; Cln", "protein_names_uniprotkb": "Calmegin; A2/6; Calnexin-T; MEG 1 antigen", "protein_names_refseq": "MEG 1 antigen; calmegin isoform 1 precursor; calnexin-T", "tax_id": 10090, "disease": "", "pathway": " (mmu:12745)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10495883;11784061;15151931;16870943;21183079;8126001;8188695;9177349;9434179", "class_list": "glycogene", "function": "Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplasmic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YU3;Q9D2K5", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007339 binding of sperm to zona pellucida;GO:0030154 cell differentiation;GO:0007338 single fertilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52194-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TWN3-1", "uniprot_id": [ { "id": "CNNM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TWN3", "type": "external" } ], "mass": 96704.0, "length": 875, "protein_name": "Metal transporter CNNM2", "gene_name": "Cnnm2", "organism": "Mouse", "refseq_name": "metal transporter CNNM2 isoform b", "refseq_ac": [ { "id": "NP_001095941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095941", "type": "external" } ], "gene_names_uniprotkb": "Cnnm2; Acdp2", "gene_names_refseq": "Acdp2; Clp2; Cnnm2", "protein_names_uniprotkb": "Metal transporter CNNM2; Ancient conserved domain-containing protein 2; Cyclin-M2; mACDP2", "protein_names_refseq": "ancient conserved domain protein 2; ancient conserved domain-containing protein 2; cyclin-like protein 2; mACDP2; metal transporter CNNM2 isoform b; metal transporter CNNM2", "tax_id": 10090, "disease": "renal hypomagnesemia 6 (Disease Ontology:DOID:0060884); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:94219)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14723793;15899945;19349973;22399287;33859252;36210013;38149326", "class_list": "", "function": "ACDP2 may provide a regulated transporter for Mg2+ and other divalent cations in epithelial ce, [RefSeq, PubMed]; Analysis of structure of CNNM2 and its post-translational modifications, [RefSeq, PubMed]; Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects. Publication Status: Online-Only, [RefSeq, PubMed]; Dimerization of the CNNM extracellular domain., [RefSeq, PubMed]; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0PJF1;E9PUH1;Q7TT07;Q8C8V4;Q9JIM8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0010960 magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3TWN3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YA9-1", "uniprot_id": [ { "id": "CNKR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YA9", "type": "external" } ], "mass": 117396.0, "length": 1032, "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "Cnksr2", "organism": "Mouse", "refseq_name": "connector enhancer of kinase suppressor of ras 2 isoform 2", "refseq_ac": [ { "id": "NP_001297648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297648", "type": "external" } ], "gene_names_uniprotkb": "Cnksr2; Kiaa0902", "gene_names_refseq": "Cnk2; Cnksr2; Ksr2", "protein_names_uniprotkb": "Connector enhancer of kinase suppressor of ras 2; CNK homolog protein 2; CNK2; Connector enhancer of KSR 2", "protein_names_refseq": "CNK homolog protein 2; connector enhancer of KSR 2; connector enhancer of KSR2; connector enhancer of kinase suppressor of ras 2 isoform 2", "tax_id": 10090, "disease": "syndromic X-linked mental retardation Hough type (Disease Ontology:DOID:0080242)", "pathway": " (mmu:245684); (R-MMU-5674135)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15345747;16452087;21183079;21750661;22517741;22645316;32848054;33300544;34580165;34678516;34800437;36803960;40885482", "class_list": "", "function": "Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome., [RefSeq, PubMed]; May function as an adapter protein or regulator of Ras signaling pathways., [UniProtKB]; S-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons., [RefSeq, PubMed]; The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q80TP2", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0009966 regulation of signal transduction;GO:0007167 enzyme-linked receptor protein signaling pathway;GO:0099173 postsynapse organization;GO:0099084 postsynaptic specialization organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q80YA9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMA3-1", "uniprot_id": [ { "id": "CNKR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMA3", "type": "external" } ], "mass": 61870.0, "length": 555, "protein_name": "Connector enhancer of kinase suppressor of ras 3", "gene_name": "Cnksr3", "organism": "Mouse", "refseq_name": "connector enhancer of kinase suppressor of ras 3", "refseq_ac": [ { "id": "NP_766134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766134", "type": "external" } ], "gene_names_uniprotkb": "Cnksr3", "gene_names_refseq": "6820402C05; Cnksr3; Magi1", "protein_names_uniprotkb": "Connector enhancer of kinase suppressor of ras 3; CNK homolog protein 3; CNK3; CNKSR family member 3; Connector enhancer of KSR 3; Maguin-like protein", "protein_names_refseq": "CNK homolog protein 3; CNK3; connector enhancer of KSR 3; connector enhancer of kinase suppressor of ras 3; maguin-like protein; membrane associated guanylate kinase interacting protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215748)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;19567370;21183079;22851176", "class_list": "", "function": "CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis., [RefSeq, PubMed]; CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney., [RefSeq, PubMed]; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDS2;Q8K2K0", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0010765 positive regulation of sodium ion transport;GO:2000651 positive regulation of sodium ion transmembrane transporter activity;GO:0033137 negative regulation of peptidyl-serine phosphorylation;GO:0007167 enzyme-linked receptor protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BMA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35329-1", "uniprot_id": [ { "id": "CD22_MOUSE", "url": "https://www.uniprot.org/uniprot/P35329", "type": "external" } ], "mass": 97181.0, "length": 868, "protein_name": "B-cell receptor CD22", "gene_name": "Cd22", "organism": "Mouse", "refseq_name": "B-cell receptor CD22 precursor", "refseq_ac": [ { "id": "NP_001036782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036782", "type": "external" } ], "gene_names_uniprotkb": "Cd22; Lyb-8; Siglec2", "gene_names_refseq": "A530093D23; Cd22; Lyb-8; Lyb8", "protein_names_uniprotkb": "B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14", "protein_names_refseq": "B-cell receptor CD22 precursor; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; T-cell surface antigen Leu-14; sialic acid-binding Ig-like lectin 2; siglec-2", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745)", "pathway": " (mmu:12483); (R-MMU-198933); (R-MMU-5690714); (R-MMU-983695)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10373493;10501843;10748054;10975807;11465105;11551923;21183079;21750661;23704998;26495903;29187734;37671595;37696483;39627609;7533044;8100843;9016707;9601638;9890995", "class_list": "", "function": "CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage., [RefSeq, PubMed]; Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies., [RefSeq, PubMed]; Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:7533044, PubMed:9016707). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation (PubMed:9016707). Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP36;Q9JHL2;Q9JJX9;Q9JJY0;Q9JJY1;Q9R056;Q9R094;Q9WU51", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0042609 CD4 receptor binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0055037 recycling endosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0030100 regulation of endocytosis;GO:0042113 B cell activation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P35329-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84089-1", "uniprot_id": [ { "id": "ERH_MOUSE", "url": "https://www.uniprot.org/uniprot/P84089", "type": "external" } ], "mass": 12259.0, "length": 104, "protein_name": "Enhancer of rudimentary homolog", "gene_name": "Erh", "organism": "Mouse", "refseq_name": "enhancer of rudimentary homolog isoform 1", "refseq_ac": [ { "id": "NP_031977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031977", "type": "external" } ], "gene_names_uniprotkb": "Erh", "gene_names_refseq": "Erh; Mer; Prei1", "protein_names_uniprotkb": "Enhancer of rudimentary homolog; Mer", "protein_names_refseq": "enhancer of rudimentary homolog isoform 1; enhancer of rudimentary homolog; preimplantation protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13877)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15937287;16211485;19224205;20173027;21750661;25428506;25782991;30084848;30779550;30866868;34203471;34428180;35820727;37507081;9074495", "class_list": "", "function": "Knock-down of ERH gene inhibits metastasis of bladder cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; May have a role in the cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular model of the protein conformation of the mouse enhancer of rudimentary protein., [RefSeq, PubMed]; Through expression studies and utilizing a transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70659;Q14259", "ec_number_list": [], "go_molecular_function": "GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0030496 midbody;GO:0034709 methylosome", "go_biological_process": "GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P84089-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X84-1", "uniprot_id": [ { "id": "CRTC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X84", "type": "external" } ], "mass": 67027.0, "length": 619, "protein_name": "CREB-regulated transcription coactivator 3", "gene_name": "Crtc3", "organism": "Mouse", "refseq_name": "CREB-regulated transcription coactivator 3", "refseq_ac": [ { "id": "NP_776288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776288", "type": "external" } ], "gene_names_uniprotkb": "Crtc3; Torc3", "gene_names_refseq": "2610312F20Rik; 6332415K15Rik; Crtc3; TORC3", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 3; TORC-3; Transducer of CREB protein 3; Transducer of regulated cAMP response element-binding protein 3", "protein_names_refseq": "CREB-regulated transcription coactivator 3; TORC-3; transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70461)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21164481;21183079;21536665;21750661;24674967;28235073;29211348;30611118;31599954;34428180;34815795;37730843", "class_list": "", "function": "Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse., [RefSeq, PubMed]; Beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3., [RefSeq, PubMed]; CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone, [RefSeq, PubMed]; CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders. Publication Status: Online-Only, [RefSeq, PubMed]; The cAMP response element binding (CREB) coactivator Crtc3 promotes obesity by attenuating beta-adrenergic receptor signalling in adipose tissue, [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348, PubMed:30611118). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0050995 negative regulation of lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91X84-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1K7-1", "uniprot_id": [ { "id": "ADSSP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1K7", "type": "external" } ], "mass": 19476.0, "length": 174, "protein_name": "Adipose-secreted signaling protein", "gene_name": "Adissp", "organism": "Mouse", "refseq_name": "adipose-secreted signaling protein isoform 2", "refseq_ac": [ { "id": "NP_080367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080367", "type": "external" } ], "gene_names_uniprotkb": "Adissp; 1700037H04Rik", "gene_names_refseq": "1700037H04Rik; Adissp", "protein_names_uniprotkb": "Adipose-secreted signaling protein", "protein_names_refseq": "UPF0687 protein C20orf27 homolog; adipose-secreted signaling protein isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67326)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;36496438", "class_list": "", "function": "Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVT3", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0042593 glucose homeostasis;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:1990845 adaptive thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SXY1-1", "uniprot_id": [ { "id": "CYTSB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SXY1", "type": "external" } ], "mass": 118101.0, "length": 1067, "protein_name": "Cytospin-B", "gene_name": "Specc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Specc1; Cytsb; Kiaa4061", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:432572)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17242355;18299400;19144319;21183079;21750661;25605945;27802388;30084848;30779550;31219806;31599954;34428180;34887587", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTQ5;Q5SXY0;Q8BKR3;Q8BL39", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0008306 associative learning;GO:0030036 actin cytoskeleton organization;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5SXY1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NBX1-1", "uniprot_id": [ { "id": "COBL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NBX1", "type": "external" } ], "mass": 143865.0, "length": 1337, "protein_name": "Protein cordon-bleu", "gene_name": "Cobl", "organism": "Mouse", "refseq_name": "protein cordon-bleu isoform 1", "refseq_ac": [ { "id": "NP_766084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766084", "type": "external" } ], "gene_names_uniprotkb": "Cobl; Kiaa0633", "gene_names_refseq": "Cobl", "protein_names_uniprotkb": "Protein cordon-bleu", "protein_names_refseq": "protein cordon-bleu isoform 1; protein cordon-bleu", "tax_id": 10090, "disease": "", "pathway": " (mmu:12808)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14512015;15345747;17956734;21183079;21750661;23009842;23223303;31219806;34264190;34678516;34898601;36852467;37507081;7586755", "class_list": "", "function": "Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells., [UniProtKB, PubMed, PubMed]; Poststroke dendritic arbor regrowth requires the actin nucleator Cobl. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5NBX2;Q60859;Q6PAT4;Q7TQM9;Q80TV4;Q8C7Q0;Q8CE81;Q8CIM4", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0001889 liver development;GO:0048669 collateral sprouting in absence of injury;GO:0030036 actin cytoskeleton organization;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q5NBX1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7G4-1", "uniprot_id": [ { "id": "EURL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7G4", "type": "external" } ], "mass": 32883.0, "length": 290, "protein_name": "Protein EURL homolog", "gene_name": "D16Ertd472e; Eurl", "organism": "Mouse", "refseq_name": "protein EURL homolog", "refseq_ac": [ { "id": "NP_001239367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239367", "type": "external" } ], "gene_names_uniprotkb": "D16Ertd472e; Eurl; D16Ertd472e", "gene_names_refseq": "1700010I10Rik; 2310009O17Rik; D16Ertd472e; E330003K22Rik; Eurl", "protein_names_uniprotkb": "Protein EURL homolog", "protein_names_refseq": "protein EURL homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27404227", "class_list": "", "function": "Plays a role in cortical progenitor cell proliferation and differentiation (PubMed:27404227). Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway (PubMed:27404227)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0060999 positive regulation of dendritic spine development;GO:0021895 cerebral cortex neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1N9-1", "uniprot_id": [ { "id": "CODA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1N9", "type": "external" } ], "mass": 73172.0, "length": 751, "protein_name": "Collagen alpha-1(XIII) chain", "gene_name": "Col13a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XIII) chain isoform 1", "refseq_ac": [ { "id": "NP_031757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031757", "type": "external" } ], "gene_names_uniprotkb": "Col13a1", "gene_names_refseq": "Col13a1", "protein_names_uniprotkb": "Collagen alpha-1(XIII) chain", "protein_names_refseq": "collagen alpha-1(XIII) chain isoform 1; collagen alpha-1(XIII) chain; procollagen, type XIII, alpha 1; type XIII collagen", "tax_id": 10090, "disease": "congenital myasthenic syndrome 19 (Disease Ontology:DOID:0110673)", "pathway": " (mmu:12817); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-216083); (R-MMU-8948216)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10429945;11470398;11566879;11583983;16007336;21750661;25428506;26626625;35393492;9624150", "class_list": "", "function": "Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O70575", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0031012 extracellular matrix;GO:0045211 postsynaptic membrane;GO:0005604 basement membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion;GO:0098609 cell-cell adhesion;GO:0001763 morphogenesis of a branching structure", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R1N9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97792-1", "uniprot_id": [ { "id": "CXAR_MOUSE", "url": "https://www.uniprot.org/uniprot/P97792", "type": "external" } ], "mass": 39948.0, "length": 365, "protein_name": "Coxsackievirus and adenovirus receptor homolog", "gene_name": "Cxadr", "organism": "Mouse", "refseq_name": "coxsackievirus and adenovirus receptor homolog isoform a precursor", "refseq_ac": [ { "id": "NP_001020363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020363", "type": "external" } ], "gene_names_uniprotkb": "Cxadr; Car", "gene_names_refseq": "2610206D03Rik; CAR; Cxadr; MCAR; MCVADR", "protein_names_uniprotkb": "Coxsackievirus and adenovirus receptor homolog; CAR; mCAR", "protein_names_refseq": "coxsackievirus and adenovirus receptor homolog isoform a precursor; coxsackievirus and adenovirus receptor homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:13052); (R-MMU-198933); (R-MMU-202733)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10814828;12763576;12823902;15533241;17242355;20181587;20813954;20813955;21183079;21674029;21750661;22645316;25428506;30899004;34428180;9036860;9096397;9420240", "class_list": "", "function": "CAR exerts important functions in the physiology of several organs in vivo, [RefSeq, PubMed]; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene, [RefSeq, PubMed]; This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O09052;Q3ULD0;Q91W66;Q99KG0;Q9DBJ8", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0007507 heart development;GO:0051607 defense response to virus;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P97792-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22892-1", "uniprot_id": [ { "id": "AP1G1_MOUSE", "url": "https://www.uniprot.org/uniprot/P22892", "type": "external" } ], "mass": 91350.0, "length": 822, "protein_name": "AP-1 complex subunit gamma-1", "gene_name": "Ap1g1", "organism": "Mouse", "refseq_name": "AP-1 complex subunit gamma-1 isoform 2", "refseq_ac": [ { "id": "NP_001288140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288140", "type": "external" } ], "gene_names_uniprotkb": "Ap1g1; Adtg; Clapg1", "gene_names_refseq": "Adtg; Ap1g1; D8Ertd374e", "protein_names_uniprotkb": "AP-1 complex subunit gamma-1; Adaptor protein complex AP-1 subunit gamma-1; Adaptor-related protein complex 1 subunit gamma-1; Clathrin adaptor protein 1 core; Clathrin assembly protein complex 1 gamma-1 large chain; Gamma-adaptin; Gamma1-adaptin; Golgi adaptor HA1/AP1 adaptin subunit gamma-1", "protein_names_refseq": "AP-1 complex subunit gamma-1 isoform 2; AP-1 complex subunit gamma-1; adapter-related protein complex 1 subunit gamma-1; adaptor protein complex AP-1 subunit gamma-1; adaptor-related protein complex 1 subunit gamma-1; clathrin adaptor protein 1 core; clathrin assembly protein complex 1 gamma-1 large chain; gamma-adaptin; gamma1-adaptin; golgi adaptor HA1/AP1 adaptin subunit gamma-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11765); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12176391;15377783;2126014;27090238;31219806;33300544;33725478;34428180;35820727;37507081;37828378;39627609", "class_list": "", "function": "Ap1g1 (fgt) mutant mice provide a new animal model to study the in vivo roles of gamma-1 adaptin and the AP-1 complex throughout development and to investigate factors that underlie its associated phenotypic abnormalities, [RefSeq, PubMed]; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0031267 small GTPase binding;GO:0019894 kinesin binding;GO:0030742 GTP-dependent protein binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005905 clathrin-coated pit;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0060155 platelet dense granule organization;GO:0016192 vesicle-mediated transport;GO:0016182 synaptic vesicle budding from endosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P22892-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8L1-1", "uniprot_id": [ { "id": "CHD5_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8L1", "type": "external" } ], "mass": 222515.0, "length": 1946, "protein_name": "ATP-dependent chromatin remodeler CHD5", "gene_name": "Chd5", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD5 isoform 3", "refseq_ac": [ { "id": "NP_001356172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001356172", "type": "external" } ], "gene_names_uniprotkb": "Chd5; Kiaa0444", "gene_names_refseq": "4930532L22Rik; B230399N07Rik; CHD-5; Chd5", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD5; 3.6.4.-; CHD-5; Chromo domain-containing protein 5", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD5 isoform 3; ATP-dependent chromatin remodeler CHD5; ATP-dependent helicase CHD5; chromo domain-containing protein 5", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:269610); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "17289567;20484733;21183079;21750661;21931736;22235338;23318260;23948251;24252660;25428506;27806305;34428180;36636025", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor that binds DNA through histones and regulates gene transcription (PubMed:23318260). May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 (PubMed:23318260, PubMed:23948251). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:27806305). Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation (PubMed:23948251, PubMed:27806305). In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages (PubMed:23948251). Regulates the expression of genes involved in cell proliferation and differentiation (PubMed:17289567). Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation (PubMed:17289567). In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa (PubMed:24252660)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; CHD5 regulates expression of neuronal genes, cell cycle genes and remodeling genes, and is linked to regulation of genes implicated in aging and Alzheimer's disease., [RefSeq, PubMed]; Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation., [RefSeq, PubMed]; The association of between miR-211-regulated CHD5 expression and CHD5 function in colorectal tumorigenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQB2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0008285 negative regulation of cell population proliferation;GO:0006366 transcription by RNA polymerase II;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2A8L1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AUM9-1", "uniprot_id": [ { "id": "CE152_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AUM9", "type": "external" } ], "mass": 196534.0, "length": 1736, "protein_name": "Centrosomal protein of 152 kDa", "gene_name": "Cep152", "organism": "Mouse", "refseq_name": "centrosomal protein of 152 kDa", "refseq_ac": [ { "id": "NP_001074560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560", "type": "external" } ], "gene_names_uniprotkb": "Cep152; Kiaa0912", "gene_names_refseq": "Cep152; mKIAA0912", "protein_names_uniprotkb": "Centrosomal protein of 152 kDa; Cep152", "protein_names_refseq": "centrosomal protein of 152 kDa", "tax_id": 10090, "disease": "Seckel syndrome 5 (Disease Ontology:DOID:0070012); primary autosomal recessive microcephaly 9 (Disease Ontology:DOID:0070292)", "pathway": " (mmu:99100); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "23806337;24240477;34428180", "class_list": "", "function": "Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (By similarity). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (By similarity). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (PubMed:24240477). Overexpression of cep152 can drive amplification of centrioles., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZV8;Q8R0X1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0016604 nuclear body;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030030 cell projection organization;GO:0051298 centrosome duplication;GO:0007099 centriole replication;GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AUM9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q309-1", "uniprot_id": [ { "id": "CE350_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q309", "type": "external" } ], "mass": 346456.0, "length": 3095, "protein_name": "Centrosome-associated protein 350", "gene_name": "Cep350", "organism": "Mouse", "refseq_name": "centrosome-associated protein 350", "refseq_ac": [ { "id": "NP_001034273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034273", "type": "external" } ], "gene_names_uniprotkb": "Cep350; Kiaa0480", "gene_names_refseq": "4933409L06Rik; 6430546F08Rik; Cep350", "protein_names_uniprotkb": "Centrosome-associated protein 350; Cep350", "protein_names_refseq": "centrosome-associated protein 350", "tax_id": 10090, "disease": "", "pathway": " (mmu:74081)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17242355;19144319;21183079;21750661;25428506;27965440;30779550;33300544;34418053;34428180;35820727;36852467;40021952", "class_list": "", "function": "Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5RMJ4;D3YTP2;Q6A062;Q8BXM7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:1905515 non-motile cilium assembly;GO:0071539 protein localization to centrosome;GO:0034453 microtubule anchoring", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9Q309-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7P9-1", "uniprot_id": [ { "id": "CDHR2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7P9", "type": "external" } ], "mass": 142633.0, "length": 1308, "protein_name": "Cadherin-related family member 2", "gene_name": "Cdhr2", "organism": "Mouse", "refseq_name": "cadherin-related family member 2 precursor", "refseq_ac": [ { "id": "NP_001028536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028536", "type": "external" } ], "gene_names_uniprotkb": "Cdhr2", "gene_names_refseq": "Cdhr2; Gm624; PC-LKC; Pcdh24", "protein_names_uniprotkb": "Cadherin-related family member 2", "protein_names_refseq": "cadherin-related family member 2 precursor; protocadherin 24; protocadherin LKC", "tax_id": 10090, "disease": "", "pathway": " (mmu:268663)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;25428506;26812017;30403560;39292922", "class_list": "", "function": "CDHR2 functions to elongate microvilli and maximize their numbers on the apical surface, which together serve to increase the functional capacity of enterocyte., [RefSeq, PubMed]; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells., [UniProtKB, UniProtKB]; Loss of intermicrovillar adhesion factor CDHR2 impairs basolateral junctional complexes in transporting epithelia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZP46;B9EJ32;Q3UN77", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0005902 microvillus", "go_biological_process": "GO:0007155 cell adhesion;GO:0030855 epithelial cell differentiation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:1904970 brush border assembly;GO:0032532 regulation of microvillus length", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9Q7P9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q70KF4-1", "uniprot_id": [ { "id": "CMYA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q70KF4", "type": "external" } ], "mass": 413040.0, "length": 3739, "protein_name": "Cardiomyopathy-associated protein 5", "gene_name": "Cmya5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cmya5; Sr553; Srfsd; Tims", "gene_names_refseq": "", "protein_names_uniprotkb": "Cardiomyopathy-associated protein 5; Heart and skeletal muscle-specific and sprouty domain-containing; Myospryn; Stretch-response protein 553; Stretch-responsive fibronectin protein type 3; TRIM-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76469)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14688250;16407236;17499862;17872945;18252718;20634290;21183079;21427212;21750661;25428506;28740084;29187734;34418053;36288343;39927985;40885482", "class_list": "", "function": "May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration. Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q70X91;Q9CV01;Q9CV02;Q9ER93;Q9ER96", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0031430 M band;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0014733 regulation of skeletal muscle adaptation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q70KF4-1", "record_type": "protein", "filter_code": "0000000.1100101.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31809-1", "uniprot_id": [ { "id": "CEAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P31809", "type": "external" } ], "mass": 57016.0, "length": 521, "protein_name": "Cell adhesion molecule CEACAM1", "gene_name": "Ceacam1", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001034274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034274", "type": "external" } ], "gene_names_uniprotkb": "Ceacam1; Bgp1; Bgp", "gene_names_refseq": "Bgp1; Bgp; C-CAM; CD66a; Cc1; Cea-1; Cea-7; Cea1; Cea7; Ceacam1; Hv-2; Hv2; MHVR1; MHVR; Mhv-1; bb-1; mCEA1; mmCGM1a; mmCGM1; mmCGM2", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM1; BGP-1; Biliary glycoprotein 1; Biliary glycoprotein D; CEA cell adhesion molecule 1; Carcinoembryonic antigen-related cell adhesion molecule 1; MHV-R; MHVR1; Murine hepatitis virus receptor", "protein_names_refseq": "BGP-1; CEA-related cell adhesion molecule 1; MHV-R; biliary glycoprotein 1; biliary glycoprotein D; carcinoembryonic antigen 1; carcinoembryonic antigen 7; carcinoembryonic antigen-related cell adhesion molecule 1; cell adhesion molecule CEACAM1 isoform 1 precursor; cell adhesion molecule CEACAM1; hepatitis virus (MHV-4) susceptibility; hepatitis virus receptor; murine hepatitis virus receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:26365); (R-MMU-1566977); (R-MMU-163125); (R-MMU-202733); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 39, "publication_id_list": "10.1101/2023.09.13.557529;11501563;11694516;11980704;11994468;15331748;15467833;1633107;1648219;16680193;16944957;17081782;1719235;18544705;19008452;19349973;21029969;21081647;21750661;22496641;22962327;23123061;23696226;25363763;25428506;25490771;25908210;29187734;30084848;34428180;37531413;38381498;39168268;39627609;8380065;8500759;8896983;9047385;9867848", "class_list": "", "function": "(Microbial infection) In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein., [UniProtKB, PubMed, PubMed]; Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha enhances tolerance to hepatic ischemia in mice and humans., [RefSeq, PubMed]; Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:16680193, PubMed:17081782, PubMed:18544705, PubMed:21029969, PubMed:21081647, PubMed:22496641, PubMed:22962327, PubMed:23696226). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors (PubMed:17081782, PubMed:21029969, PubMed:22496641). Plays a role in immune response, of T-cells, natural killer (NK) and neutrophils (PubMed:17081782, PubMed:21029969, PubMed:22496641, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:22496641). Also inhibits T-cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T-cell through its interaction with HAVCR2 (PubMed:17081782). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome (PubMed:22496641). Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (PubMed:21029969). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (PubMed:18544705). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia (PubMed:16680193, PubMed:22962327). Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (PubMed:21081647). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (PubMed:15467833). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (PubMed:19008452). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (By similarity). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (PubMed:25490771)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (PubMed:1633107). Promotes populations of T-cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (PubMed:23123061)., [UniProtKB, PubMed, PubMed]; Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation., [RefSeq, PubMed]; Loss of CEACAM1 in hepatocytes causes hepatic fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q61350;Q61353", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0032703 negative regulation of interleukin-2 production;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P31809-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1A3B0-1", "uniprot_id": [ { "id": "CERS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1A3B0", "type": "external" } ], "mass": 46081.0, "length": 383, "protein_name": "Ceramide synthase 3", "gene_name": "Cers3", "organism": "Mouse", "refseq_name": "ceramide synthase 3", "refseq_ac": [ { "id": "NP_001157673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157673", "type": "external" } ], "gene_names_uniprotkb": "Cers3; Lass3", "gene_names_refseq": "4930550L11Rik; Cers3; Gm488; Lass3; T3L; mCerS3", "protein_names_uniprotkb": "Ceramide synthase 3; 2.3.1.24; 2.3.1.297; 2.3.1.298; CerS3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; Sphingosine N-acyltransferase CERS3; Ultra-long-chain ceramide synthase CERS3; Very-long-chain ceramide synthase CERS3; mCerS3", "protein_names_refseq": "LAG1 homolog, ceramide synthase 3; LAG1 longevity assurance homolog 3; ceramide synthase 3; dihydroceramide synthase 3; longevity assurance homolog 3; related to TRH3; sphingosine N-acyltransferase CERS3; ultra-long-chain ceramide synthase CERS3; very-long-chain ceramide synthase CERS3", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 9 (Disease Ontology:DOID:0060718)", "pathway": " (mmu:545975); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16753040;18308723;18541923;21183079;22038835", "class_list": "glycogene", "function": "Both glycans and the particular acyl chains of germinal sphingolipids are relevant for proper completion of meiosis, [RefSeq, PubMed]; Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:16753040, PubMed:18541923, PubMed:22038835). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:16753040, PubMed:18541923, PubMed:22038835). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:22038835)., [UniProtKB, PubMed, PubMed, PubMed]; The isolation and characterization of LASS3 and LASS3-long are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PVY9;Q195J4", "ec_number_list": [ { "id": "2.3.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.24", "type": "external" }, { "id": "2.3.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.299", "type": "external" }, { "id": "2.3.1.298", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.298", "type": "external" }, { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.291", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.291", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0008544 epidermis development;GO:0030148 sphingolipid biosynthetic process;GO:0030216 keratinocyte differentiation;GO:0070268 cornification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q1A3B0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQ06-1", "uniprot_id": [ { "id": "CE162_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQ06", "type": "external" } ], "mass": 160855.0, "length": 1403, "protein_name": "Centrosomal protein of 162 kDa", "gene_name": "Cep162", "organism": "Mouse", "refseq_name": "centrosomal protein of 162 kDa", "refseq_ac": [ { "id": "NP_955020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955020", "type": "external" } ], "gene_names_uniprotkb": "Cep162; Kiaa1009; Qn1", "gene_names_refseq": "4922501C03Rik; Cep162; mKIAA1009", "protein_names_uniprotkb": "Centrosomal protein of 162 kDa; Cep162; Protein QN1 homolog", "protein_names_refseq": "centrosomal protein of 162 kDa; protein QN1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:382090); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12522145;21183079;31219806;34428180;35820727;39627609", "class_list": "", "function": "Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKN3;Q6P262", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6ZQ06-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ64-1", "uniprot_id": [ { "id": "CHDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ64", "type": "external" } ], "mass": 66415.0, "length": 596, "protein_name": "Choline dehydrogenase, mitochondrial", "gene_name": "Chdh", "organism": "Mouse", "refseq_name": "choline dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001129712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129712", "type": "external" } ], "gene_names_uniprotkb": "Chdh", "gene_names_refseq": "Chdh; D630034H06Rik", "protein_names_uniprotkb": "Choline dehydrogenase, mitochondrial; 1.1.99.1; CDH; CHD", "protein_names_refseq": "CDH; CHD; choline dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:218865); (R-MMU-6798163)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20371614;23576753;23806337;26740625;28663368;31255657;34428180;37453647", "class_list": "", "function": "CHDH variant, rs35518479, was identified as a cis-expression quantitative trait locus (QTL) for CHDH expression in postmortem brains from schizophrenia, allowing genotype-based stratification of schizophrenia patients for betaine efficacy, [RefSeq, PubMed]; Catalyzes the dehydrogenation of choline to betaine aldehyde in the mitochondria (PubMed:20371614). Involved in mitochondrial autophagy after mitochondrial damage (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization). Erratum:[J Biol Chem. 2020 Jul 31;295(31):10868. doi: 10.1074/jbc.AAC120.015069. PMID: 32737146], [RefSeq, PubMed]; Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males Erratum:[FASEB J. 2018 May;32(5):2899. doi: 10.1096/fj.09-153718ERR. PMID: 29698116], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPY4;Q8CHT7", "ec_number_list": [ { "id": "1.1.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.1", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0008812 choline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019285 glycine betaine biosynthetic process from choline", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BJ64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0W1-1", "uniprot_id": [ { "id": "CIPC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0W1", "type": "external" } ], "mass": 46320.0, "length": 432, "protein_name": "CLOCK-interacting pacemaker", "gene_name": "Cipc", "organism": "Mouse", "refseq_name": "CLOCK-interacting pacemaker isoform a", "refseq_ac": [ { "id": "NP_001276359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276359", "type": "external" } ], "gene_names_uniprotkb": "Cipc; Kiaa1737", "gene_names_refseq": "2310044G17Rik; Cipc", "protein_names_uniprotkb": "CLOCK-interacting pacemaker; CLOCK-interacting circadian protein", "protein_names_refseq": "CLOCK-interacting circadian protein; CLOCK-interacting pacemaker isoform a; CLOCK-interacting pacemaker", "tax_id": 10090, "disease": "", "pathway": " (mmu:217732)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17310242;19414601;21750661;25862660;34428180;35705041", "class_list": "", "function": "MRNA expression profiles of core clock genes in the liver of Cipc (-/-) mice showed no significant differences from that in wild-type mice except for Per1, [RefSeq, PubMed]; Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice., [RefSeq, PubMed]; Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601). However, the physiological relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUN6;Q3U423;Q3UFM0;Q80T99;Q8C680", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0048511 rhythmic process;GO:0042754 negative regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R0W1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZH8-1", "uniprot_id": [ { "id": "CCD77_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZH8", "type": "external" } ], "mass": 57569.0, "length": 489, "protein_name": "Coiled-coil domain-containing protein 77", "gene_name": "Ccdc77", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 77 isoform 1", "refseq_ac": [ { "id": "NP_080304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080304", "type": "external" } ], "gene_names_uniprotkb": "Ccdc77", "gene_names_refseq": "2400002C23Rik; 2700091N06Rik; Ccdc77", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 77", "protein_names_refseq": "coiled-coil domain-containing protein 77 isoform 1; coiled-coil domain-containing protein 77", "tax_id": 10090, "disease": "", "pathway": " (mmu:67200)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEJ7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5R3-1", "uniprot_id": [ { "id": "CEP83_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5R3", "type": "external" } ], "mass": 81998.0, "length": 692, "protein_name": "Centrosomal protein of 83 kDa", "gene_name": "Cep83", "organism": "Mouse", "refseq_name": "centrosomal protein of 83 kDa", "refseq_ac": [ { "id": "NP_084128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084128", "type": "external" } ], "gene_names_uniprotkb": "Cep83; Ccdc41", "gene_names_refseq": "2600001G24Rik; 4921537D05Rik; 5730513H21Rik; Ccdc41; Cep83", "protein_names_uniprotkb": "Centrosomal protein of 83 kDa; Cep83; Coiled-coil domain-containing protein 41", "protein_names_refseq": "centrosomal protein of 83 kDa; coiled-coil domain containing 41; coiled-coil domain-containing protein 41", "tax_id": 10090, "disease": "nephronophthisis 18 (Disease Ontology:DOID:0111125)", "pathway": " (mmu:77048); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17971504;18299400;21183079;23348840;25428506;30084848;31219806;34428180", "class_list": "", "function": "4921537D05Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7X7;Q3UX57;Q80VF0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005814 centriole;GO:0097539 ciliary transition fiber", "go_biological_process": "GO:0060271 cilium assembly;GO:0071539 protein localization to centrosome;GO:0048278 vesicle docking;GO:0051660 establishment of centrosome localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D5R3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJV4-1", "uniprot_id": [ { "id": "CCG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJV4", "type": "external" } ], "mass": 36535.0, "length": 327, "protein_name": "Voltage-dependent calcium channel gamma-4 subunit", "gene_name": "Cacng4", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-4 subunit", "refseq_ac": [ { "id": "NP_062304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062304", "type": "external" } ], "gene_names_uniprotkb": "Cacng4", "gene_names_refseq": "Cacng4", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-4 subunit; Neuronal voltage-gated calcium channel gamma-4 subunit; TARP gamma-4; Transmembrane AMPAR regulatory protein gamma-4", "protein_names_refseq": "TARP gamma-4; neuronal voltage-gated calcium channel gamma-4 subunit; transmembrane AMPAR regulatory protein gamma-4; voltage-dependent calcium channel gamma-4 subunit", "tax_id": 10090, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:54377); (R-MMU-112308); (R-MMU-399719); (R-MMU-5576892); (R-MMU-5576893); (R-MMU-5682910)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10734232;11389205;17880894;21183079", "class_list": "", "function": "Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:17880894)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0009986 cell surface;GO:0032281 AMPA glutamate receptor complex;GO:0044297 cell body;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0042220 response to cocaine;GO:2000969 positive regulation of AMPA receptor activity;GO:0019226 transmission of nerve impulse", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JJV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJV5-1", "uniprot_id": [ { "id": "CCG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJV5", "type": "external" } ], "mass": 35516.0, "length": 315, "protein_name": "Voltage-dependent calcium channel gamma-3 subunit", "gene_name": "Cacng3", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-3 subunit", "refseq_ac": [ { "id": "NP_062303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062303", "type": "external" } ], "gene_names_uniprotkb": "Cacng3", "gene_names_refseq": "Cacng3", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; TARP gamma-3; Transmembrane AMPAR regulatory protein gamma-3", "protein_names_refseq": "TARP gamma-3; neuronal voltage-gated calcium channel gamma-3 subunit; transmembrane AMPAR regulatory protein gamma-3; voltage-dependent calcium channel gamma-3 subunit", "tax_id": 10090, "disease": "childhood absence epilepsy (Disease Ontology:DOID:1825); macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (mmu:54376); (R-MMU-399719); (R-MMU-5682910)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10734232;17114649;18341993;21750661;22534482;22645316", "class_list": "", "function": "Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs) (PubMed:18341993). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This study demonistrated that Cacng3 gene expression in mouse dorsal raphe nucleus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6R5", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0032281 AMPA glutamate receptor complex;GO:0036477 somatodendritic compartment;GO:0060076 excitatory synapse", "go_biological_process": "GO:0006605 protein targeting;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:2000969 positive regulation of AMPA receptor activity;GO:0019226 transmission of nerve impulse;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJV5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSH4-1", "uniprot_id": [ { "id": "CP110_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSH4", "type": "external" } ], "mass": 111139.0, "length": 1004, "protein_name": "Centriolar coiled-coil protein of 110 kDa", "gene_name": "Ccp110", "organism": "Mouse", "refseq_name": "centriolar coiled-coil protein of 110 kDa isoform 1", "refseq_ac": [ { "id": "NP_892040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892040", "type": "external" } ], "gene_names_uniprotkb": "Ccp110; Cep110; Cp110; Kiaa0419", "gene_names_refseq": "6330503K22Rik; CP110; Ccp110; cep110", "protein_names_uniprotkb": "Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; Cep110; Cp110", "protein_names_refseq": "centriolar coiled-coil protein of 110 kDa isoform 1; centriolar coiled-coil protein of 110 kDa; centrosomal protein CP110; centrosomal protein of 110 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:101565); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5689880); (R-MMU-8854518); (R-MMU-9013424)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23141541;23807208;26670998;26965371;30375385;35301795", "class_list": "", "function": "ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis., [RefSeq, PubMed]; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:23141541). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (PubMed:26965371). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6A072", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005814 centriole;GO:0032991 protein-containing complex", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0051298 centrosome duplication;GO:0032465 regulation of cytokinesis;GO:0045724 positive regulation of cilium assembly;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TSH4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23242-1", "uniprot_id": [ { "id": "CXA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P23242", "type": "external" } ], "mass": 43004.0, "length": 382, "protein_name": "Gap junction alpha-1 protein", "gene_name": "Gja1", "organism": "Mouse", "refseq_name": "gap junction alpha-1 protein", "refseq_ac": [ { "id": "NP_034418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034418", "type": "external" } ], "gene_names_uniprotkb": "Gja1; Cxn-43", "gene_names_refseq": "Cnx43; Cx43alpha1; Cx43; Cxnk1; Gja-1; Gja1; Npm1; connexin43", "protein_names_uniprotkb": "Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein", "protein_names_refseq": "alpha 1 connexin; connexin k1; connexin-43; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); atrial fibrillation (Disease Ontology:DOID:0060224); oculodentodigital dysplasia (Disease Ontology:DOID:0060291); overactive bladder syndrome (Disease Ontology:DOID:0070355); erythrokeratodermia variabilis et progressiva 3 (Disease Ontology:DOID:0080249); autosomal recessive craniometaphyseal dysplasia (Disease Ontology:DOID:0080802); Parkinsonism (Disease Ontology:DOID:0080855); palmoplantar keratoderma and congenital alopecia 1 (Disease Ontology:DOID:0111244); syndactyly type 3 (Disease Ontology:DOID:0111817); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); urethral obstruction (Disease Ontology:DOID:12577); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); renovascular hypertension (Disease Ontology:DOID:1591); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); palmoplantar keratosis (Disease Ontology:DOID:3390); borna disease (Disease Ontology:DOID:5154); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); autoimmune thyroiditis (Disease Ontology:DOID:7188); myocarditis (Disease Ontology:DOID:820); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:14609); (R-MMU-190840); (R-MMU-190861); (R-MMU-190873); (R-MMU-191650); (R-MMU-196025); (R-MMU-9013406)", "pathway_count": 7, "publication_count": 60, "publication_id_list": "10.1101/2023.09.13.557529;11741837;12209934;1318884;15181016;15213231;15709751;1708769;17114649;17765619;18034455;18079109;19864490;20016202;2060697;20940304;21071693;21183079;21750661;21753195;2178193;22049024;22549838;22729691;23261543;23587598;23596417;24492000;24498049;25428506;25952543;26085008;26403541;27034963;27097562;27281705;28202692;28507509;28528544;28935953;29019935;29269353;29462621;29518932;29578247;29959233;30084848;31219806;31422747;32464326;32739526;33142723;33300544;33751227;34428180;35701117;36288343;37507081;8395450;9472011", "class_list": "", "function": "Connexin 43 is possibly the ATP-induced pore of mouse macrophages., [UniProtKB, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in the conductive system of ventricular myocardium and heart morphogenesis (PubMed:26403541). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 31, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q544I7;Q8CE05", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0005102 signaling receptor binding;GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding;GO:0015267 channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0045836 positive regulation of meiotic nuclear division;GO:2000648 positive regulation of stem cell proliferation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "P23242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58466-1", "uniprot_id": [ { "id": "CTDS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P58466", "type": "external" } ], "mass": 29266.0, "length": 261, "protein_name": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1", "gene_name": "Ctdsp1", "organism": "Mouse", "refseq_name": "carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2", "refseq_ac": [ { "id": "NP_694728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694728", "type": "external" } ], "gene_names_uniprotkb": "Ctdsp1; Nif3; Nliif", "gene_names_refseq": "Ctdsp1; GIP; NLIIF; Nif3; SCP1", "protein_names_uniprotkb": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; 3.1.3.16; GIP; Golli-interacting protein; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; NLI-interacting factor 3; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; golli-interacting protein; nuclear LIM interactor-interacting factor 3; small C-terminal domain phosphatase 1; small CTD phosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227292)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15681389;18625321;21750661;24751520;28440748;34428180", "class_list": "", "function": "Consistently, the authors observed increased AKT phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly, they discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus. Erratum:[Elife. 2017 Oct 17;6:e32342. doi: 10.7554/eLife.32342. PMID: 29039735] Publication Status: Online-Only, [RefSeq, PubMed]; Expression and purification of the active variant of recombinant murine Golli-interacting protein (GIP) and its characterization, [RefSeq, PubMed]; Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ('quick-brake mechanism') on SCP1/GIP., [RefSeq, PubMed]; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045665 negative regulation of neuron differentiation;GO:0001933 negative regulation of protein phosphorylation;GO:0006470 protein dephosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P58466-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88712-1", "uniprot_id": [ { "id": "CTBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88712", "type": "external" } ], "mass": 47745.0, "length": 441, "protein_name": "C-terminal-binding protein 1", "gene_name": "Ctbp1", "organism": "Mouse", "refseq_name": "C-terminal-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001185788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185788", "type": "external" } ], "gene_names_uniprotkb": "Ctbp1", "gene_names_refseq": "BARS; CtBP3/BARS; Ctbp1; D4S115h; D5H4S115E; D5H4S115", "protein_names_uniprotkb": "C-terminal-binding protein 1; 1.1.1.-; CtBP1", "protein_names_refseq": "C-terminal-binding protein 1 isoform 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:13016); (R-MMU-3769402); (R-MMU-3899300); (R-MMU-4641265); (R-MMU-9764725)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10369679;10567582;11022042;14567915;14701752;14736873;16326862;16702210;18483224;19103759;19696312;21750661;30084848;31219806;31599954;33300544;34428180;34678516;37906993;40684658;40885482", "class_list": "", "function": "Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Expression Analyses of C-Terminal-Binding Protein 1 (CtBP1) during Mouse Brain Development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAT1;Q3TDL5;Q3TUM5;Q91WI6;Q91YX3;Q9QYG2", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O88712-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56546-1", "uniprot_id": [ { "id": "CTBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P56546", "type": "external" } ], "mass": 48957.0, "length": 445, "protein_name": "C-terminal-binding protein 2", "gene_name": "Ctbp2", "organism": "Mouse", "refseq_name": "C-terminal-binding protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001164215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164215", "type": "external" } ], "gene_names_uniprotkb": "Ctbp2", "gene_names_refseq": "Ctbp2; D7Ertd45e; Gtrgeo6; Ribeye", "protein_names_uniprotkb": "C-terminal-binding protein 2; CtBP2", "protein_names_refseq": "C-terminal-binding protein 2 isoform 1; gene trap ROSA b-geo 6", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:13017); (R-MMU-4641265); (R-MMU-9764725)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10567582;14736873;16702210;16940172;18483224;21750661;24129315;31219806;33300544;34428180;34678516;40885482;9479502;9724649", "class_list": "", "function": "Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity). Functions in brown adipose tissue (BAT) differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54855;O88462", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050872 white fat cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P56546-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61462-1", "uniprot_id": [ { "id": "CY24A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61462", "type": "external" } ], "mass": 20748.0, "length": 192, "protein_name": "Cytochrome b-245 light chain", "gene_name": "Cyba", "organism": "Mouse", "refseq_name": "cytochrome b-245 light chain isoform 2", "refseq_ac": [ { "id": "NP_001288213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288213", "type": "external" } ], "gene_names_uniprotkb": "Cyba", "gene_names_refseq": "Cyba; b558; nmf333; p22-phox; p22phox", "protein_names_uniprotkb": "Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox", "protein_names_refseq": "cytochrome b(558) alpha chain; cytochrome b-245 light chain isoform 2; cytochrome b-245 light chain; cytochrome b558 subunit alpha; cytochrome beta-558; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22 phox; superoxide-generating NADPH oxidase light chain subunit", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); autosomal recessive chronic granulomatous disease 4 (Disease Ontology:DOID:0070193); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); phagocyte bactericidal dysfunction (Disease Ontology:DOID:3262); chronic granulomatous disease (Disease Ontology:DOID:3265); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13057); (R-MMU-1222556); (R-MMU-1236973); (R-MMU-3299685); (R-MMU-4420097); (R-MMU-5668599); (R-MMU-6798695); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "15123630;19144319;19755709;21183079;21551061;2597164;26194095;28351984;31219806;34428180;35051590;36210013", "class_list": "", "function": "Cytochrome b558 expression is downregulated via the reduction of heme availability after NADPH oxidase is inhibited by HO-1, [RefSeq, PubMed]; Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (By similarity). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U820;Q9CWB9;Q9D2W2", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0020037 heme binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0006954 inflammatory response;GO:0030307 positive regulation of cell growth;GO:0032930 positive regulation of superoxide anion generation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61462-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62018-1", "uniprot_id": [ { "id": "CTR9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62018", "type": "external" } ], "mass": 133408.0, "length": 1173, "protein_name": "RNA polymerase-associated protein CTR9 homolog", "gene_name": "Ctr9", "organism": "Mouse", "refseq_name": "RNA polymerase-associated protein CTR9 homolog", "refseq_ac": [ { "id": "NP_033457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033457", "type": "external" } ], "gene_names_uniprotkb": "Ctr9; Kiaa0155; Sh2bp1", "gene_names_refseq": "Ctr9; Sh2bp1; Tsbp; Tsp; mKIAA0155", "protein_names_uniprotkb": "RNA polymerase-associated protein CTR9 homolog; SH2 domain-binding protein 1; TPR-containing, SH2-binding phosphoprotein of 150 kDa; Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa; p150TSP", "protein_names_refseq": "Ctr9, Paf1/RNA polymerase II complex component, homolog; RNA polymerase-associated protein CTR9 homolog; SH2 domain binding protein 1 (tetratricopeptide repeat containing); SH2 domain-binding protein 1; TPR-containing, SH2-binding phosphoprotein of 150 kDa; p150TSP; tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:22083); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955); (R-MMU-8866654)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "15345747;17242355;17911113;19131326;19345177;21183079;22872234;27749823;27864380;28612505;31219806;34203471;34428180;36210013;39627609;8636124", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3., [UniProtKB, UniProtKB, PubMed, PubMed]; Our data suggest that Setd5 is required for maintaining PGC-associated genes and Setd5-associated protein complexes containing Tbl1xr1 and Ctr9, which in turn are likely involved in regulating germ cell-related genes in mESCs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFF5;Q3UY40;Q66JX4;Q7TPS6;Q8BND9;Q8BRD1;Q8C9W7;Q8C9Y3;Q8CHI1", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0001829 trophectodermal cell differentiation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62018-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ40-1", "uniprot_id": [ { "id": "CROCC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ40", "type": "external" } ], "mass": 226945.0, "length": 2009, "protein_name": "Rootletin", "gene_name": "Crocc", "organism": "Mouse", "refseq_name": "rootletin isoform 2", "refseq_ac": [ { "id": "NP_001139430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139430", "type": "external" } ], "gene_names_uniprotkb": "Crocc; Kiaa0445", "gene_names_refseq": "Crocc", "protein_names_uniprotkb": "Rootletin; Ciliary rootlet coiled-coil protein", "protein_names_refseq": "ciliary rootlet coiled-coil protein; rootletin isoform 2; rootletin", "tax_id": 10090, "disease": "", "pathway": " (mmu:230872)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12427867;15870283;16339073;21183079;21750661;25428506;33596093;34428180;36210013", "class_list": "", "function": "Data indicate that ciliary rootlets are composed of homopolymeric rootletin protofilaments bundled into variably shaped thick filaments., [RefSeq, PubMed]; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (PubMed:12427867). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (By similarity). Contributes to centrosome cohesion before mitosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Roles for ELMOD2 and Rootletin in ciliogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AA81;Q7TQL2;Q80U01;Q8R0B9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005198 structural molecule activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0035253 ciliary rootlet", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0008104 intracellular protein localization;GO:0007098 centrosome cycle;GO:0010669 epithelial structure maintenance;GO:0051656 establishment of organelle localization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CJ40-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQX2-1", "uniprot_id": [ { "id": "CYB5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQX2", "type": "external" } ], "mass": 16318.0, "length": 146, "protein_name": "Cytochrome b5 type B", "gene_name": "Cyb5b", "organism": "Mouse", "refseq_name": "cytochrome b5 type B precursor", "refseq_ac": [ { "id": "NP_079834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079834", "type": "external" } ], "gene_names_uniprotkb": "Cyb5b; Cyb5m", "gene_names_refseq": "1810044O22Rik; Cyb5b; Cyb5m", "protein_names_uniprotkb": "Cytochrome b5 type B; Cytochrome b5 outer mitochondrial membrane isoform", "protein_names_refseq": "cytochrome b5 type B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66427); (R-MMU-1660661); (R-MMU-203615); (R-MMU-211945)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "14739275;16075062;17208939;17242355;21183079;24788674;25153642;25605945;28528544;30084848;32152506;34428180;36288343;37453647", "class_list": "", "function": "Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases., [UniProtKB]; Microsomal cytochrome b5 interacts with neuronal calcium sensor protein visinin-like protein-3 in a Ca2+-dependent manner, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1M6;Q9D8R3", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0050421 nitrite reductase (NO-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:1903958 nitric-oxide synthase complex", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CQX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z140-1", "uniprot_id": [ { "id": "CPNE6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z140", "type": "external" } ], "mass": 61781.0, "length": 557, "protein_name": "Copine-6", "gene_name": "Cpne6", "organism": "Mouse", "refseq_name": "copine-6 isoform a", "refseq_ac": [ { "id": "NP_001129529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129529", "type": "external" } ], "gene_names_uniprotkb": "Cpne6", "gene_names_refseq": "Cpne6", "protein_names_uniprotkb": "Copine-6; Copine VI; N-copine; Neuronal-copine", "protein_names_refseq": "N-copine; copine-6 isoform a; copine-6; neuronal-copine", "tax_id": 10090, "disease": "", "pathway": " (mmu:12891); (R-MMU-1483206)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10403379;17114649;21087455;21750661;26175110;27194588;29802203;9645480;9886090", "class_list": "", "function": "Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2018]., [RefSeq]; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (PubMed:9886090). Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, PubMed, UniProtKB]; Links activity-triggered calcium signals to spine structural plasticity necessary for learning and memory Publication Status: Online-Only, [RefSeq, PubMed]; The second C2-domain of copine-6 is responsible for calcium-dependent membrane association., [RefSeq, PubMed]; We identify copine-6 as a specific regulator of spontaneous neurotransmission, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion;GO:0098974 postsynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z140-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHS9-1", "uniprot_id": [ { "id": "CWC15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHS9", "type": "external" } ], "mass": 26624.0, "length": 229, "protein_name": "Spliceosome-associated protein CWC15 homolog", "gene_name": "Cwc15", "organism": "Mouse", "refseq_name": "spliceosome-associated protein CWC15 homolog", "refseq_ac": [ { "id": "NP_075642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075642", "type": "external" } ], "gene_names_uniprotkb": "Cwc15; Ed1", "gene_names_refseq": "0610040D20Rik; 2900052N06Rik; Cwc15; Ed1; c11orf5; mED1", "protein_names_uniprotkb": "Spliceosome-associated protein CWC15 homolog; Embryonic development factor 1; mED1", "protein_names_refseq": "embryonic development factor 1; nucleoporin; protein CWC15 homolog; spliceosome-associated protein CWC15 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66070); (R-MMU-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10873569;21183079;21750661;23806337", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH98;Q9CTH0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JHS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88327-1", "uniprot_id": [ { "id": "CTNL1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88327", "type": "external" } ], "mass": 81462.0, "length": 731, "protein_name": "Alpha-catulin", "gene_name": "Ctnnal1", "organism": "Mouse", "refseq_name": "alpha-catulin", "refseq_ac": [ { "id": "NP_061231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061231", "type": "external" } ], "gene_names_uniprotkb": "Ctnnal1; Catnal1", "gene_names_refseq": "ACRP; Catnal1; Ctnnal1", "protein_names_uniprotkb": "Alpha-catulin; ACRP; Alpha-catenin-related protein; Catenin alpha-like protein 1", "protein_names_refseq": "alpha-catenin related protein; alpha-catulin; catenin (cadherin associated protein), alpha-like 1; catenin alpha-like protein 1", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:54366)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17647259;19726720;21183079;21750661;22577143;25428506;29187734;30084848;34203471;34428180;38602002", "class_list": "", "function": "CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway., [RefSeq, PubMed]; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1)., [UniProtKB]; This study identifies the E-cadherin/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4/IL-13-exposed alternatively activated macrophages, [RefSeq, PubMed]; We observed the temporal and spatial distribution of CTNNAL1 expression in mouse lung tissue with the OVA-sensitized asthma model and found that the level of CTNNAL1 mRNA showed a prominent negative correlation with pulmonary resistance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810J3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005737 cytoplasm", "go_biological_process": "GO:0007155 cell adhesion;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88327-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26231-1", "uniprot_id": [ { "id": "CTNA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P26231", "type": "external" } ], "mass": 100106.0, "length": 906, "protein_name": "Catenin alpha-1", "gene_name": "Ctnna1", "organism": "Mouse", "refseq_name": "catenin alpha-1", "refseq_ac": [ { "id": "NP_033948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033948", "type": "external" } ], "gene_names_uniprotkb": "Ctnna1; Catna1", "gene_names_refseq": "2010010M04Rik; Catna1; Ctnna1", "protein_names_uniprotkb": "Catenin alpha-1; 102 kDa cadherin-associated protein; Alpha E-catenin; CAP102", "protein_names_refseq": "102 kDa cadherin-associated protein; CAP102; alpha E-catenin; cadherin associated protein; catenin (cadherin associated protein), alpha 1; catenin alpha-1", "tax_id": 10090, "disease": "patterned macular dystrophy 2 (Disease Ontology:DOID:0060864); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive lobular carcinoma (Disease Ontology:DOID:3457); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:12385); (R-MMU-418990); (R-MMU-5218920); (R-MMU-525793); (R-MMU-5626467); (R-MMU-9764561); (R-MMU-9766229); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 9, "publication_count": 27, "publication_id_list": "10026224;10882138;11907041;16325582;16325583;18093941;18630941;1904011;19131326;1924379;21145499;21183079;21750661;22645316;22872234;25653389;26691986;31219806;32152506;34428180;34887587;36210013;36288343;37453647;37507081;37828378;7982500", "class_list": "", "function": "Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). May play a crucial role in cell differentiation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0043297 apical junction assembly;GO:0016477 cell migration;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P26231-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61301-1", "uniprot_id": [ { "id": "CTNA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61301", "type": "external" } ], "mass": 105286.0, "length": 953, "protein_name": "Catenin alpha-2", "gene_name": "Ctnna2", "organism": "Mouse", "refseq_name": "catenin alpha-2 isoform 2", "refseq_ac": [ { "id": "NP_001103234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103234", "type": "external" } ], "gene_names_uniprotkb": "Ctnna2; Catna2", "gene_names_refseq": "Catna2; Catna; Ctnna2; cdf; chp", "protein_names_uniprotkb": "Catenin alpha-2; Alpha N-catenin", "protein_names_refseq": "alpha(N)-catenin; catenin (cadherin associated protein), alpha 2; catenin alpha-2 isoform 2; cerebellar deficient folia", "tax_id": 10090, "disease": "complex cortical dysplasia with other brain malformations 9 (Disease Ontology:DOID:0061138); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12386); (R-MMU-525793)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11465105;12089526;12123610;15034585;15345747;16185771;16452087;16457793;16691566;17114649;21183079;21750661;21913724;22872234;25428506;29187734;31219806;33300544;34428180;8174789", "class_list": "", "function": "May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (PubMed:12123610, PubMed:15034585). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (PubMed:12089526)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY37;Q61300;Q6AXD1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098831 presynaptic active zone cytoplasmic component;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0007409 axonogenesis;GO:0016477 cell migration;GO:0060134 prepulse inhibition;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q61301-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q65CL1-1", "uniprot_id": [ { "id": "CTNA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q65CL1", "type": "external" } ], "mass": 99803.0, "length": 895, "protein_name": "Catenin alpha-3", "gene_name": "Ctnna3", "organism": "Mouse", "refseq_name": "catenin alpha-3 isoform 1", "refseq_ac": [ { "id": "NP_001157848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157848", "type": "external" } ], "gene_names_uniprotkb": "Ctnna3; Catna3", "gene_names_refseq": "4930429L08Rik; 4933408A16; Catna3; Ctnna3; Vr22", "protein_names_uniprotkb": "Catenin alpha-3; Alpha T-catenin; Cadherin-associated protein", "protein_names_refseq": "alpha T-catenin; alpha-catenin-like protein; alphaT-catenin; cadherin-associated protein; catenin (cadherin associated protein), alpha 3; catenin alpha-3 isoform 1", "tax_id": 10090, "disease": "esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); childhood-onset asthma (Disease Ontology:DOID:0080815); occupational asthma (Disease Ontology:DOID:0080820); arrhythmogenic right ventricular dysplasia 13 (Disease Ontology:DOID:0110084); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:216033)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11590244;12596047;16452087;17535849;21183079;22645316;35820727;37507081", "class_list": "", "function": "May be involved in formation of stretch-resistant cell-cell adhesion complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ61;Q8C0N3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0030027 lamellipodium;GO:0005916 fascia adherens;GO:0030057 desmosome", "go_biological_process": "GO:0016477 cell migration;GO:0086091 regulation of heart rate by cardiac conduction;GO:0098609 cell-cell adhesion;GO:0098911 regulation of ventricular cardiac muscle cell action potential;GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q65CL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5N3-1", "uniprot_id": [ { "id": "CWC22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5N3", "type": "external" } ], "mass": 104773.0, "length": 908, "protein_name": "Pre-mRNA-splicing factor CWC22 homolog", "gene_name": "Cwc22", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor CWC22 homolog isoform 3", "refseq_ac": [ { "id": "NP_001277669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277669", "type": "external" } ], "gene_names_uniprotkb": "Cwc22; Ncm", "gene_names_refseq": "B230213M24; Cwc22; mKIAA1604", "protein_names_uniprotkb": "Pre-mRNA-splicing factor CWC22 homolog; Nucampholin homolog", "protein_names_refseq": "CWC22 spliceosome-associated protein homolog; nucampholin homolog; pre-mRNA-splicing factor CWC22 homolog isoform 3; pre-mRNA-splicing factor CWC22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:80744); (R-MMU-72163)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "17242355;19224205;20173027;21183079;21750661;25428507;25605945;26149421;27371833;28250049;33300544;34428180;35820727;37838283", "class_list": "", "function": "Authors have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies reveals that they have been subject to nonallelic gene conversion events spanning tens of kilobases., [RefSeq, PubMed]; CWC22-Mediated Alternative Splicing of Spp1 Regulates Nociception in Inflammatory Pain., [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations., [RefSeq, PubMed]; These findings identify subtle but significant alterations in spliceosome structure and function, including dysregulated Cajal bodies and CWC22 overexpression, in diabetic sensory neurons that offer new ideas regarding diabetic sensory neurodegeneration in polyneuropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEH0;Q3V267;Q8BR58;Q99KV6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C5N3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U3E2-1", "uniprot_id": [ { "id": "F117B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U3E2", "type": "external" } ], "mass": 61345.0, "length": 584, "protein_name": "Protein FAM117B", "gene_name": "Fam117b", "organism": "Mouse", "refseq_name": "protein FAM117B", "refseq_ac": [ { "id": "NP_001032814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032814", "type": "external" } ], "gene_names_uniprotkb": "Fam117b; Als2cr13", "gene_names_refseq": "2810425F24Rik; 6330416D14Rik; Als2cr13; Fam117b", "protein_names_uniprotkb": "Protein FAM117B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein homolog", "protein_names_refseq": "amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein homolog; protein FAM117B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72750)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;22645316;25428506;26192747;30084848;31219806;32782141;32848054;36852467;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q68EE3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q3U3E2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U2I3-1", "uniprot_id": [ { "id": "FHI1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U2I3", "type": "external" } ], "mass": 106541.0, "length": 975, "protein_name": "FHF complex subunit HOOK-interacting protein 1B", "gene_name": "Fhip1b", "organism": "Mouse", "refseq_name": "FHF complex subunit HOOK-interacting protein 1B isoform a", "refseq_ac": [ { "id": "NP_001229292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229292", "type": "external" } ], "gene_names_uniprotkb": "Fhip1b; Fam160a2; Kiaa1759", "gene_names_refseq": "4632419K20Rik; 6530415H11Rik; FHIP; Fam160a2; Fhip1b", "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 1B; FHIP; FTS- and Hook-interacting protein", "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 1B isoform a; FTS and Hook-interacting protein; family with sequence similarity 160, member A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74349)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;30084848;31219806", "class_list": "", "function": "Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWF5;Q6P543;Q80T93;Q811J6;Q8BI34;Q8VE55", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070695 FHF complex", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U2I3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D952-1", "uniprot_id": [ { "id": "EVPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D952", "type": "external" } ], "mass": 232012.0, "length": 2035, "protein_name": "Envoplakin", "gene_name": "Evpl", "organism": "Mouse", "refseq_name": "envoplakin", "refseq_ac": [ { "id": "NP_079552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079552", "type": "external" } ], "gene_names_uniprotkb": "Evpl", "gene_names_refseq": "Evpl", "protein_names_uniprotkb": "Envoplakin; 210 kDa cornified envelope precursor protein; p210", "protein_names_refseq": "210 kDa cornified envelope precursor protein; 210-kD protein; 210kDa protein; envoplakin; p210", "tax_id": 10090, "disease": "", "pathway": " (mmu:14027); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10747979;11564887;18166659;21183079;25428506;29187734;30084848;34428180", "class_list": "", "function": "Although envoplakin is part of the scaffolding on which the epidermal cornified envelope is assembled, it is not essential for envelope formation or epidermal barrier function., [RefSeq, PubMed]; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments., [UniProtKB]; Thus, combined loss of the cornified envelope proteins not only impairs the epidermal barrier, but also changes the composition of T cell subpopulations in the skin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AU57", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0045111 intermediate filament cytoskeleton;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking;GO:0042060 wound healing;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D952-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCM0-1", "uniprot_id": [ { "id": "ETHE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCM0", "type": "external" } ], "mass": 27739.0, "length": 254, "protein_name": "Persulfide dioxygenase ETHE1, mitochondrial", "gene_name": "Ethe1", "organism": "Mouse", "refseq_name": "persulfide dioxygenase ETHE1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_075643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075643", "type": "external" } ], "gene_names_uniprotkb": "Ethe1; Hsco", "gene_names_refseq": "0610025L15Rik; Ethe1; Hsco", "protein_names_uniprotkb": "Persulfide dioxygenase ETHE1, mitochondrial; 1.13.11.18; Ethylmalonic encephalopathy protein 1 homolog; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1", "protein_names_refseq": "ethylmalonic encephalopathy protein 1 homolog; hepatoma subtracted clone one protein; persulfide dioxygenase ETHE1, mitochondrial precursor; persulfide dioxygenase ETHE1, mitochondrial; protein ETHE1, mitochondrial; sulfur dioxygenase ETHE1", "tax_id": 10090, "disease": "ethylmalonic encephalopathy (Disease Ontology:DOID:0060640)", "pathway": " (mmu:66071); (R-MMU-1614517)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19136963;21183079;23576753;23800285;23806337;31219806;34428180", "class_list": "", "function": "Ethe1 deficiency disrupts post translational amino acid modification and mitochondrial metabolic systems. Publication Status: Online-Only, [RefSeq, PubMed]; First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (By similarity). Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESL5", "ec_number_list": [ { "id": "1.13.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.18", "type": "external" }, { "id": "1.8.5.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0050313 sulfur dioxygenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070813 hydrogen sulfide metabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DCM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUA5-1", "uniprot_id": [ { "id": "EPM2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUA5", "type": "external" } ], "mass": 36958.0, "length": 330, "protein_name": "Laforin", "gene_name": "Epm2a", "organism": "Mouse", "refseq_name": "laforin", "refseq_ac": [ { "id": "NP_034276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034276", "type": "external" } ], "gene_names_uniprotkb": "Epm2a", "gene_names_refseq": "Epm2a; TG-B; TcrbK)TG-BFlv; Tg(TcraK", "protein_names_uniprotkb": "Laforin; 3.1.3.-; 3.1.3.16; 3.1.3.48; Glucan phosphatase; LAFPTPase; Lafora PTPase", "protein_names_refseq": "LAFPTPase; glucan phosphatase; lafora PTPase; laforin", "tax_id": 10090, "disease": "Lafora disease 1 (Disease Ontology:DOID:0070660); Lafora disease (Disease Ontology:DOID:3534); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (mmu:13853)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10092504;11355878;12019206;16971387;18040046;18852261;19036738;19542233;20453062;22669944;23624058;23663739;24068615;24430976;37059210", "class_list": "glycogene", "function": "Epm2a[R240X] knock-in mice present earlier cognitive decline and more epileptic activity than Epm2a[-/-] mice., [RefSeq, PubMed]; Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin (PubMed:18040046, PubMed:18852261, PubMed:19036738, PubMed:23663739, PubMed:24068615, PubMed:24430976). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:16971387, PubMed:24430976). Has also been shown to dephosphorylate MAPT (PubMed:19542233). Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:18040046, PubMed:18852261, PubMed:23663739). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS) (PubMed:19036738, PubMed:24068615). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E8E2;Q8BY80", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046959 habituation;GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0000045 autophagosome assembly;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WUA5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL04-1", "uniprot_id": [ { "id": "FMN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL04", "type": "external" } ], "mass": 167387.0, "length": 1578, "protein_name": "Formin-2", "gene_name": "Fmn2", "organism": "Mouse", "refseq_name": "formin-2", "refseq_ac": [ { "id": "NP_062318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062318", "type": "external" } ], "gene_names_uniprotkb": "Fmn2", "gene_names_refseq": "Fmn2", "protein_names_uniprotkb": "Formin-2", "protein_names_refseq": "formin-2", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 47 (Disease Ontology:DOID:0081211)", "pathway": " (mmu:54418)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10781961;12447394;15053972;17114649;18848445;19062278;21183079;21620703;21705804;21750661;21983562;22517741;22645316;25428506;32848054;33547291;35820727;35822049;38086376;40021952;40885482", "class_list": "", "function": "Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:18848445, PubMed:21620703). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:18848445, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (PubMed:12447394, PubMed:18848445, PubMed:19062278, PubMed:21620703). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (By similarity). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity). Protects cells against apoptosis by protecting CDKN1A against degradation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Formin-2 is a maternal-effect gene that is expressed in oocytes and is required for progression through metaphase of meiosis I, [RefSeq, PubMed]; Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair., [RefSeq, PubMed]; The mouse formin-2 gene has been found to be expressed in the developing nervous system and in neuronal cells of the adult brain., [RefSeq, PubMed]; Two mechanisms drive pronuclear migration in mouse zygotes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q505D3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9JL04-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09100-1", "uniprot_id": [ { "id": "GATA2_MOUSE", "url": "https://www.uniprot.org/uniprot/O09100", "type": "external" } ], "mass": 50468.0, "length": 480, "protein_name": "Endothelial transcription factor GATA-2", "gene_name": "Gata2", "organism": "Mouse", "refseq_name": "endothelial transcription factor GATA-2", "refseq_ac": [ { "id": "NP_032116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032116", "type": "external" } ], "gene_names_uniprotkb": "Gata2", "gene_names_refseq": "Gata-2; Gata2", "protein_names_uniprotkb": "Endothelial transcription factor GATA-2; GATA-binding protein 2", "protein_names_refseq": "endothelial transcription factor GATA-2", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 21 (Disease Ontology:DOID:0111947); pre-eclampsia (Disease Ontology:DOID:10591); aplastic anemia (Disease Ontology:DOID:12449); depressive disorder (Disease Ontology:DOID:1596); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:14461); (R-MMU-8939236); (R-MMU-983231)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15837948;21536911;21750661;25670854;34428180;35235341;36210013;9452491", "class_list": "", "function": "Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0010725 regulation of primitive erythrocyte differentiation;GO:0035854 eosinophil fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O09100-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22339-1", "uniprot_id": [ { "id": "GA45B_MOUSE", "url": "https://www.uniprot.org/uniprot/P22339", "type": "external" } ], "mass": 17783.0, "length": 160, "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 beta", "gene_name": "Gadd45b", "organism": "Mouse", "refseq_name": "growth arrest and DNA damage-inducible protein GADD45 beta", "refseq_ac": [ { "id": "NP_032681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032681", "type": "external" } ], "gene_names_uniprotkb": "Gadd45b; Myd118", "gene_names_refseq": "Gadd45b; Myd118", "protein_names_uniprotkb": "Growth arrest and DNA damage-inducible protein GADD45 beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118", "protein_names_refseq": "growth arrest and DNA damage-inducible protein GADD45 beta; myeloid differentiation primary response gene 118; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118", "tax_id": 10090, "disease": "", "pathway": " (mmu:17873)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11403721;12162804;1899477;21750661;31219806;37917584;38843934", "class_list": "", "function": "Gadd45beta is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation., [RefSeq, PubMed]; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity)., [UniProtKB]; Nono induces Gadd45b to mediate DNA repair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U342;Q9R106", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22339-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AD83-1", "uniprot_id": [ { "id": "FRMD7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AD83", "type": "external" } ], "mass": 80330.0, "length": 703, "protein_name": "FERM domain-containing protein 7", "gene_name": "Frmd7", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 7", "refseq_ac": [ { "id": "NP_001177261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177261", "type": "external" } ], "gene_names_uniprotkb": "Frmd7", "gene_names_refseq": "EG665849; Frmd7; Gm1533", "protein_names_uniprotkb": "FERM domain-containing protein 7", "protein_names_refseq": "FERM domain-containing protein 7", "tax_id": 10090, "disease": "congenital nystagmus 1 (Disease Ontology:DOID:0111790)", "pathway": " (mmu:385354)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19892780;21750661;22128244;26711119", "class_list": "", "function": "A novel splice variant of FRMD7 (FRMD7-S) with a shortened exon 4 relative to the original form of FRMD7 (FRMD7-FL) was identified from the cDNA of the human NT2 cell line and mouse fetal brain., [RefSeq, PubMed]; FRMD7 as a key regulator in establishing a neuronal circuit asymmetry, [RefSeq, PubMed]; FRMD7 expression is spatially and temporally regulated in human and mouse brain during embryonic and fetal development., [RefSeq, PubMed]; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCP8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0007399 nervous system development;GO:0010975 regulation of neuron projection development;GO:0010592 positive regulation of lamellipodium assembly;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2AD83-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TD3-1", "uniprot_id": [ { "id": "FNIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TD3", "type": "external" } ], "mass": 122520.0, "length": 1108, "protein_name": "Folliculin-interacting protein 2", "gene_name": "Fnip2", "organism": "Mouse", "refseq_name": "folliculin-interacting protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001156471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156471", "type": "external" } ], "gene_names_uniprotkb": "Fnip2; Kiaa1450; Mapo1", "gene_names_refseq": "D630023B12Rik; Fnip2; mKIAA1450", "protein_names_uniprotkb": "Folliculin-interacting protein 2; O6-methylguanine-induced apoptosis 1 protein", "protein_names_refseq": "FNIP1-like protein; O6-methylguanine-induced apoptosis 1 protein; folliculin-interacting protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:329679); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19137017;19144319;21183079;21750661;22209521;23582324;24129315;25428506;25775561;31219806", "class_list": "", "function": "Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (By similarity). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (By similarity). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (PubMed:19137017)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn, [RefSeq, PubMed]; The involvement of the AMPK-MAPO1-FLCN complex in the signaling pathway of apoptosis, is described., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0034451 centriolar satellite;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0031334 positive regulation of protein-containing complex assembly;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80TD3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23772-1", "uniprot_id": [ { "id": "GATA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P23772", "type": "external" } ], "mass": 47968.0, "length": 443, "protein_name": "Trans-acting T-cell-specific transcription factor GATA-3", "gene_name": "Gata3", "organism": "Mouse", "refseq_name": "trans-acting T-cell-specific transcription factor GATA-3 isoform 1", "refseq_ac": [ { "id": "NP_032117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032117", "type": "external" } ], "gene_names_uniprotkb": "Gata3; Gata-3", "gene_names_refseq": "Gata-3; Gata3; jal", "protein_names_uniprotkb": "Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3", "protein_names_refseq": "GATA-binding factor 3; trans-acting T-cell-specific transcription factor GATA-3 isoform 1; trans-acting T-cell-specific transcription factor GATA-3", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); hypoparathyroidism-retardation-dysmorphism syndrome (Disease Ontology:DOID:0060348); hypoparathyroidism-deafness-renal disease syndrome (Disease Ontology:DOID:0060878); sensorineural hearing loss (Disease Ontology:DOID:10003); hypoparathyroidism (Disease Ontology:DOID:11199); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (mmu:14462); (R-MMU-5689880); (R-MMU-8939236); (R-MMU-9018519); (R-MMU-983231)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "15662016;17056504;18621058;2017177;21183079;21690296;21750661;23616576;31175139;34428180;34644537", "class_list": "", "function": "Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (PubMed:31175139). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045061 thymic T cell selection;GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0060017 parathyroid gland development;GO:0035162 embryonic hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P23772-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JP7-1", "uniprot_id": [ { "id": "GGT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JP7", "type": "external" } ], "mass": 70251.0, "length": 662, "protein_name": "Glutathione hydrolase 7", "gene_name": "Ggt7", "organism": "Mouse", "refseq_name": "glutathione hydrolase 7 isoform 2", "refseq_ac": [ { "id": "NP_659035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659035", "type": "external" } ], "gene_names_uniprotkb": "Ggt7; Ggtl3", "gene_names_refseq": "1110017C11Rik; 6330563L03Rik; Ggt7; Ggtl3", "protein_names_uniprotkb": "Glutathione hydrolase 7; 2.3.2.2; 3.4.19.13; GGT 7; Gamma-glutamyltransferase 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltranspeptidase 7", "protein_names_refseq": "GGT 7; gamma-glutamyltransferase-like 3; gamma-glutamyltranspeptidase 7; glutathione hydrolase 7 isoform 2; glutathione hydrolase 7; mFLJ00311 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:207182); (R-MMU-174403); (R-MMU-5423646); (R-MMU-9753281)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11471062;17114649;21183079;21750661;25428506;30084848;30779550;30899004;34428180;40885482", "class_list": "", "function": "Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A2AQN1;Q91V91", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:1902883 negative regulation of response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q99JP7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97855-1", "uniprot_id": [ { "id": "G3BP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97855", "type": "external" } ], "mass": 51829.0, "length": 465, "protein_name": "Ras GTPase-activating protein-binding protein 1", "gene_name": "G3bp1", "organism": "Mouse", "refseq_name": "ras GTPase-activating protein-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_038744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038744", "type": "external" } ], "gene_names_uniprotkb": "G3bp1; G3bp", "gene_names_refseq": "B430204O07; G3bp1; G3bp; mKIAA4115", "protein_names_uniprotkb": "Ras GTPase-activating protein-binding protein 1; 3.6.4.12; 3.6.4.13; ATP-dependent DNA helicase VIII; G3BP-1; GAP SH3 domain-binding protein 1; HDH-VIII", "protein_names_refseq": "ATP-dependent DNA helicase VIII; G3BP-1; GAP SH3 binding protein; GAP SH3 domain-binding protein 1; GTPase activating protein (SH3 domain) binding protein 1; HDH-VIII; Ras-GTPase-activating protein SH3-domain binding protein 1; ras GTPase-activating protein-binding protein 1 isoform 1; ras GTPase-activating protein-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27041)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;11604510;15086518;15345747;17242355;19131326;19144319;21183079;21952136;22645316;24129315;25428506;25605945;30016717;30084848;30510222;30779550;31219806;32782141;32848054;33065005;34418053;34428180;34887587;35820727;36288343;36511898;36738734;36852467;37453647;37870259;40885482;8649363", "class_list": "", "function": "Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules., [RefSeq, PubMed]; Protein involved in various processes, such as stress granule formation and innate immunity (By similarity). Plays an essential role in stress granule formation (By similarity). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (By similarity). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (By similarity). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (By similarity). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (By similarity). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (By similarity). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (By similarity). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles. Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (By similarity). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510)., [UniProtKB, UniProtKB, PubMed]; SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1., [RefSeq, PubMed]; The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043204 perikaryon;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0034063 stress granule assembly;GO:0032481 positive regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P97855-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00342-1", "uniprot_id": [ { "id": "FLT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00342", "type": "external" } ], "mass": 113496.0, "length": 1000, "protein_name": "Receptor-type tyrosine-protein kinase FLT3", "gene_name": "Flt3", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein kinase FLT3 precursor", "refseq_ac": [ { "id": "NP_034359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034359", "type": "external" } ], "gene_names_uniprotkb": "Flt3; Flk-2; Flt-3", "gene_names_refseq": "B230315G04; CD135; Flk-2; Flk2; Flt-3; Flt3; Ly72; wmfl", "protein_names_uniprotkb": "Receptor-type tyrosine-protein kinase FLT3; 2.7.10.1; FL cytokine receptor; FLK-2; FLT-3; Fetal liver kinase 2; Fms-like tyrosine kinase 3; Tyrosine-protein kinase receptor flk-2", "protein_names_refseq": "FL cytokine receptor; fetal liver kinase 2; receptor-type tyrosine-protein kinase FLT3 precursor; receptor-type tyrosine-protein kinase FLT3; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); prostate cancer (Disease Ontology:DOID:10283); myelofibrosis (Disease Ontology:DOID:4971); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14255); (R-MMU-109704); (R-MMU-1257604); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-9607240); (R-MMU-9706369); (R-MMU-9706374)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10409713;1648448;1656368;16627759;18469816;19286519;20457904;21516120;23418353;26495903;26740625;34428180;35984892;36210013;7621074;8384358;8920882", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 6, "disease_count": 10, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0031625 ubiquitin protein ligase binding;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0032727 positive regulation of interferon-alpha production;GO:0002328 pro-B cell differentiation;GO:0036145 dendritic cell homeostasis;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q00342-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U0V1-1", "uniprot_id": [ { "id": "FUBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U0V1", "type": "external" } ], "mass": 76775.0, "length": 748, "protein_name": "Far upstream element-binding protein 2", "gene_name": "Khsrp", "organism": "Mouse", "refseq_name": "far upstream element-binding protein 2", "refseq_ac": [ { "id": "NP_034743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034743", "type": "external" } ], "gene_names_uniprotkb": "Khsrp; Fubp2", "gene_names_refseq": "6330409F21Rik; Fbp2; Fubp2; Khsrp; Ksrp", "protein_names_uniprotkb": "Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP", "protein_names_refseq": "FUSE-binding protein 2; far upstream element-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16549); (R-MMU-450604)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "16364914;17242355;17525332;20485683;21183079;21540332;21750661;22645316;23806337;24129315;24788674;25153642;28135057;28528544;31219806;32782141;32848054;34831390;34887587;35798971;35820727;35822049;36288343;36852467;38480757;39187547;40021952;40684658;40885482", "class_list": "", "function": "Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity)., [UniProtKB]; KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1. Publication Status: Online-Only, [RefSeq, PubMed]; KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. Publication Status: Online-Only, [RefSeq, PubMed]; KSRP improves pancreatic beta cell function and survival. Publication Status: Online-Only, [RefSeq, PubMed]; Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QKH3;Q2VPQ6;Q6P2L2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0044183 protein folding chaperone;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006355 regulation of DNA-templated transcription;GO:0043488 regulation of mRNA stability;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q3U0V1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UCQ1-1", "uniprot_id": [ { "id": "FOXK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UCQ1", "type": "external" } ], "mass": 68446.0, "length": 651, "protein_name": "Forkhead box protein K2", "gene_name": "Foxk2", "organism": "Mouse", "refseq_name": "forkhead box protein K2 isoform 1", "refseq_ac": [ { "id": "NP_001074401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074401", "type": "external" } ], "gene_names_uniprotkb": "Foxk2; Ilf1", "gene_names_refseq": "1110054H05Rik; 5730434B08Rik; 6230415M23Rik; Foxk2; ILF; Ilf1", "protein_names_uniprotkb": "Forkhead box protein K2; Cellular transcription factor ILF-1; Interleukin enhancer-binding factor 1", "protein_names_refseq": "cellular transcription factor ILF-1; forkhead box protein K2 isoform 1; forkhead box protein K2; interleukin enhancer-binding factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68837); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "16376864;17242355;21183079;22517741;22645316;25402684;26192747;29861159;30016717;30700909;30952843;32747411;32782141;32848054;34239356;34887587;36852467;38735474;40885482;40997131", "class_list": "", "function": "CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration., [RefSeq, PubMed]; FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:32747411)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AN27;B5AZX0", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042594 response to starvation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q3UCQ1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61086-1", "uniprot_id": [ { "id": "FZD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61086", "type": "external" } ], "mass": 76208.0, "length": 666, "protein_name": "Frizzled-3", "gene_name": "Fzd3", "organism": "Mouse", "refseq_name": "frizzled-3 precursor", "refseq_ac": [ { "id": "NP_067433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067433", "type": "external" } ], "gene_names_uniprotkb": "Fzd3", "gene_names_refseq": "D930050A07Rik; Fz3; Fzd3; fz-3; mFz3", "protein_names_uniprotkb": "Frizzled-3; Fz-3; mFz3", "protein_names_refseq": "frizzled homolog 3; frizzled-3 precursor; frizzled-3", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:14365); (R-MMU-4086398); (R-MMU-4086400); (R-MMU-4608870)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10395542;11407985;12351730;14671310;16407530;16495441;16687519;21325504;24347548;24799694;30084848;8626800", "class_list": "", "function": "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0001764 neuron migration;GO:0001843 neural tube closure;GO:0001942 hair follicle development;GO:0051602 response to electrical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61086-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66JX5-1", "uniprot_id": [ { "id": "CEP43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66JX5", "type": "external" } ], "mass": 42758.0, "length": 399, "protein_name": "Centrosomal protein 43", "gene_name": "Cep43", "organism": "Mouse", "refseq_name": "centrosomal protein 43 isoform 1", "refseq_ac": [ { "id": "NP_001183975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001183975", "type": "external" } ], "gene_names_uniprotkb": "Cep43; Fgfr1op", "gene_names_refseq": "4930553O10Rik; Cep43; FOP; Fgfr1op", "protein_names_uniprotkb": "Centrosomal protein 43; FGFR1 oncogene partner", "protein_names_refseq": "Fgfr1 oncogene partner; centrosomal protein 43 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75296); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "12969958;17947660;19144319;21750661", "class_list": "", "function": "Expression of FOP-FGFR1 in primary bone marrow cells induced by retroviral transduction generates a myeloproliferative disease in mice, [RefSeq, PubMed]; Required for anchoring microtubules to the centrosomes. Required for ciliation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32P17;Q8BH91", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0030292 protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0006469 negative regulation of protein kinase activity;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66JX5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAR5-1", "uniprot_id": [ { "id": "GAPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAR5", "type": "external" } ], "mass": 162402.0, "length": 1458, "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1", "gene_name": "Gapvd1", "organism": "Mouse", "refseq_name": "GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_079985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079985", "type": "external" } ], "gene_names_uniprotkb": "Gapvd1; Gapex5; Kiaa1521", "gene_names_refseq": "2010005B09Rik; 4432404J10Rik; Gapex-5; Gapvd1; RAP6; RME-6; mKIAA1521", "protein_names_uniprotkb": "GTPase-activating protein and VPS9 domain-containing protein 1; GAPex-5; Rab5-activating protein 6", "protein_names_refseq": "GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2; GTPase-activating protein and VPS9 domain-containing protein 1; rab5-activating protein 6", "tax_id": 10090, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (mmu:66691); (R-MMU-8856828); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "16880210;17189207;17242355;17545148;18434594;19131326;19144319;21183079;21750661;25428506;26495903;30084848;30772465;31219806;31599954;34203471;34418053;34428180;36210013", "class_list": "", "function": "AMPK-dependent phosphorylation of Gapex-5 (also known as GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1)) on Ser902 in hepatocytes and starch-binding domain 1 (STBD1) on Ser175 in multiple cells/tissues, [RefSeq, PubMed]; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras., [UniProtKB, PubMed, PubMed, PubMed]; Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell., [RefSeq, PubMed]; The TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0PJI8;A2AR09;A2AR10;A2AR17;A2AR18;Q3TNS1;Q3UDL0;Q3UYD5;Q6ZPP0;Q80V37;Q80ZK4;Q8BTS5;Q9CRS2;Q9CTI1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q6PAR5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RFH4-1", "uniprot_id": [ { "id": "GCSAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RFH4", "type": "external" } ], "mass": 20988.0, "length": 181, "protein_name": "Germinal center-associated signaling and motility protein", "gene_name": "Gcsam", "organism": "Mouse", "refseq_name": "germinal center-associated signaling and motility protein isoform 1", "refseq_ac": [ { "id": "NP_001152769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152769", "type": "external" } ], "gene_names_uniprotkb": "Gcsam; Gcet2; Gcet; M17", "gene_names_refseq": "Gcet2; Gcet; Gcsam; M17-L; M17", "protein_names_uniprotkb": "Germinal center-associated signaling and motility protein; Germinal center B-cell-expressed transcript 2 protein", "protein_names_refseq": "germinal center B-cell-expressed transcript 2 protein; germinal center expressed transcript 2; germinal center-associated signaling and motility protein isoform 1; germinal center-associated signaling and motility protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14525)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11801660;15482850;21183079;21913724;23299888;26495903;26740625;28011936;35984892;7981148", "class_list": "", "function": "Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts., [RefSeq, PubMed]; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60691;Q8CB90", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0003779 actin binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:2000402 negative regulation of lymphocyte migration;GO:0050855 regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6RFH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q70KY4-1", "uniprot_id": [ { "id": "FOXO6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q70KY4", "type": "external" } ], "mass": 57595.0, "length": 559, "protein_name": "Forkhead box protein O6", "gene_name": "Foxo6", "organism": "Mouse", "refseq_name": "forkhead box protein O6", "refseq_ac": [ { "id": "NP_918949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_918949", "type": "external" } ], "gene_names_uniprotkb": "Foxo6", "gene_names_refseq": "Foxo6", "protein_names_uniprotkb": "Forkhead box protein O6", "protein_names_refseq": "forkhead box protein O6", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:329934); (R-MMU-198693); (R-MMU-9614399)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12857750;17974917;21940782;32639626;32863230;34080654;34428180;38417829", "class_list": "", "function": "Cloning and characterization; structural and functional properties related to gene regulation, [RefSeq, PubMed]; FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity., [RefSeq, PubMed]; FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity., [RefSeq, PubMed]; FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation., [RefSeq, PubMed]; Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation., [RefSeq, PubMed]; Investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in liver orchestrates insulin regulation of gluconeogenesis. FoxO6 appears to be ubiquitously expressed in mouse tissues., [RefSeq, PubMed]; Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo., [RefSeq, PubMed]; Transcriptional activator., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007613 memory;GO:0060999 positive regulation of dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q70KY4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76JU9-1", "uniprot_id": [ { "id": "FFAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q76JU9", "type": "external" } ], "mass": 31804.0, "length": 300, "protein_name": "Free fatty acid receptor 1", "gene_name": "Ffar1", "organism": "Mouse", "refseq_name": "free fatty acid receptor 1", "refseq_ac": [ { "id": "NP_918946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_918946", "type": "external" } ], "gene_names_uniprotkb": "Ffar1; Gpr40", "gene_names_refseq": "Ffar1; Gpr40", "protein_names_uniprotkb": "Free fatty acid receptor 1; G protein-coupled receptor 40", "protein_names_refseq": "G protein-coupled receptor 40; G protein-coupled receptor GPR40; free fatty acid receptor 1", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:233081); (R-MMU-381771); (R-MMU-400511); (R-MMU-416476); (R-MMU-434316); (R-MMU-444209)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "12496284;12629551;16044321;16054069;16267104;17395749;18559658;23335512;23403053;24130766;38361249", "class_list": "", "function": "G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (PubMed:23335512). Ligand binding leads to a conformation change that triggers signaling via G proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; GPR40 has the capacity to respond to fatty acids with chain lengths of four or greater., [RefSeq, PubMed]; GPR40 plays an important role in the chain of events linking obesity and type 2 diabetes., [RefSeq, PubMed]; Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment. Erratum:[Immunology. 2025 Nov;176(3):403-406. doi: 10.1111/imm.70017. PMID: 40707417], [RefSeq, PubMed]; The results demonstrate that GPR40 is indeed necessary, at least in part, for fatty-acid-stimulated insulin release., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RS88;Q8K3T5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005504 fatty acid binding;GO:0045125 bioactive lipid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032024 positive regulation of insulin secretion;GO:0032691 negative regulation of interleukin-1 beta production;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q76JU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920B0-1", "uniprot_id": [ { "id": "FRM4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920B0", "type": "external" } ], "mass": 118007.0, "length": 1035, "protein_name": "FERM domain-containing protein 4B", "gene_name": "Frmd4b", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 4B isoform 1", "refseq_ac": [ { "id": "NP_001333566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333566", "type": "external" } ], "gene_names_uniprotkb": "Frmd4b", "gene_names_refseq": "6030440G05Rik; Frmd4b; GOBLIN; GRSP1", "protein_names_uniprotkb": "FERM domain-containing protein 4B; GOBLIN; GRP1-binding protein GRSP1; Golgi-associated band 4.1-like protein", "protein_names_refseq": "FERM domain-containing protein 4B isoform 1; FERM domain-containing protein 4B; GRP1 binding protein GRSP1; golgi-associated band 4.1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:232288)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11445584;17242355;20080746;21183079;21750661;29947801;34428180;36210013", "class_list": "", "function": "His study reveals a critical role of FRMD4B in maintaining ELM integrity and in rescuing morphological abnormalities of the outer nuclear layer in photoreceptor dysplasia., [RefSeq, PubMed]; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (PubMed:20080746). Plays a redundant role with FRMD4A in epithelial polarization (PubMed:20080746)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1S1;Q920B1;Q9ESP9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0001726 ruffle", "go_biological_process": "GO:0090162 establishment of epithelial cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q920B0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1T6-2", "uniprot_id": [ { "id": "FYV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1T6", "type": "external" } ], "mass": 236877.0, "length": 2097, "protein_name": "1-phosphatidylinositol 3-phosphate 5-kinase", "gene_name": "Pikfyve", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 3-phosphate 5-kinase isoform 1", "refseq_ac": [ { "id": "NP_001297553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297553", "type": "external" } ], "gene_names_uniprotkb": "Pikfyve; Fab1; Kiaa0981; Pip5k3", "gene_names_refseq": "5230400C17Rik; Pikfyve; Pip5k3; Pip5k; Pipk5k3; PipkIII; p235", "protein_names_uniprotkb": "1-phosphatidylinositol 3-phosphate 5-kinase; 2.7.1.150; 2.7.11.1; FYVE finger-containing phosphoinositide kinase; PIKfyve; PIPkin-III; Phosphatidylinositol 3-phosphate 5-kinase type III; Phosphatidylinositol 3-phosphate 5-kinase; Serine-protein kinase PIKFYVE; Type III PIP kinase; p235", "protein_names_refseq": "1-phosphatidylinositol 3-phosphate 5-kinase isoform 1; 1-phosphatidylinositol 3-phosphate 5-kinase; FYVE finger-containing phosphoinositide kinase; PIPkin-III; PtdIns(4)P-5-kinase; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; serine-protein kinase PIKFYVE; type III PIP kinase", "tax_id": 10090, "disease": "Fleck corneal dystrophy (Disease Ontology:DOID:0060448); cataract (Disease Ontology:DOID:83); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:18711); (R-MMU-1660514); (R-MMU-1660516); (R-MMU-1660517)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10419465;10567352;11123925;14530284;17242355;17909029;17956977;19037259;19056739;20513353;21183079;21349843;22621786;22872234;23673157;25178411;25428506;27623384;28779020;29584722;30779550;31427458;34428180;37828378;38942798;41639454;9858586", "class_list": "", "function": "Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:17909029, PubMed:19037259, PubMed:22621786). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:10419465, PubMed:10567352). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:10419465, PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (By similarity) (PubMed:11123925). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (By similarity). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (PubMed:25178411, PubMed:31427458). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (By similarity). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (PubMed:22621786, PubMed:23673157). Synthesis if (PtdIns(3,5)P2) is required for the cGAS-STING pathway (PubMed:41639454). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, trhough association with SPAG9 and RABEPK (PubMed:14530284, PubMed:19056739). Mediates EGFR trafficking to the nucleus (PubMed:17909029)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PIKfyve, expressed by CD11c-positive cells, controls tumor immunity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9859, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QL40;Q3TNE4;Q3UTT6;Q69ZU1;Q9CU94", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0052810 1-phosphatidylinositol-5-kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090382 phagosome maturation;GO:0035556 intracellular signal transduction;GO:0006612 protein targeting to membrane;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0034504 protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9Z1T6-2", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1I2-1", "uniprot_id": [ { "id": "GRP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1I2", "type": "external" } ], "mass": 15659.0, "length": 146, "protein_name": "Gastrin-releasing peptide", "gene_name": "Grp", "organism": "Mouse", "refseq_name": "gastrin-releasing peptide preproprotein", "refseq_ac": [ { "id": "NP_778177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778177", "type": "external" } ], "gene_names_uniprotkb": "Grp", "gene_names_refseq": "BLP; Grp", "protein_names_uniprotkb": "Gastrin-releasing peptide; GRP-10; GRP18-27; GRP", "protein_names_refseq": "gastrin-releasing peptide preproprotein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); kidney failure (Disease Ontology:DOID:1074); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); pneumonia (Disease Ontology:DOID:552); congestive heart failure (Disease Ontology:DOID:6000); cerebrovascular disease (Disease Ontology:DOID:6713); chronic kidney disease (Disease Ontology:DOID:784); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:225642); (R-MMU-375276); (R-MMU-381771); (R-MMU-416476)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12176666;12526815;17653196;21933692;26658875;26855425;28280205;34610277", "class_list": "", "function": "Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation., [UniProtKB, PubMed]; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:17653196, PubMed:26658875, PubMed:28280205). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the regulation of food intake (PubMed:12176666). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Contributes to the induction of sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a neuropeptide hormone that affects various biological processes such as neuroendocrine regulation, gastrointestinal secretion, nociception, cell proliferation and inflammation. The encoded protein undergoes proteolytic processing to generate multiple mature peptides with biological activity. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTL2", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0043005 neuron projection", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0007218 neuropeptide signaling pathway;GO:0035176 social behavior;GO:0001503 ossification;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R1I2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEB1-1", "uniprot_id": [ { "id": "GRK5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEB1", "type": "external" } ], "mass": 67732.0, "length": 590, "protein_name": "G protein-coupled receptor kinase 5", "gene_name": "Grk5", "organism": "Mouse", "refseq_name": "G protein-coupled receptor kinase 5", "refseq_ac": [ { "id": "NP_061357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061357", "type": "external" } ], "gene_names_uniprotkb": "Grk5; Gprk5", "gene_names_refseq": "Gprk5; Grk5", "protein_names_uniprotkb": "G protein-coupled receptor kinase 5; 2.7.11.16; G protein-coupled receptor kinase GRK5", "protein_names_refseq": "G protein-coupled receptor kinase 5; g protein-coupled receptor kinase GRK5", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:14773); (R-MMU-418555)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10506199;10624964;14565944;17242355;18711143;19478075;21041302;21183079;21750661;25428506;36584571;36633120;39383830", "class_list": "", "function": "GRK5-mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction., [RefSeq, PubMed]; Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-kappaB-mediated inflammation., [RefSeq, PubMed]; Irg1 regulates bone homeostasis via regulating the Grk5 expression., [RefSeq, PubMed]; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70292;O70297", "ec_number_list": [ { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0004703 G protein-coupled receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0031965 nuclear membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VEB1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88895-1", "uniprot_id": [ { "id": "HDAC3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88895", "type": "external" } ], "mass": 48821.0, "length": 428, "protein_name": "Histone deacetylase 3", "gene_name": "Hdac3", "organism": "Mouse", "refseq_name": "histone deacetylase 3", "refseq_ac": [ { "id": "NP_034541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034541", "type": "external" } ], "gene_names_uniprotkb": "Hdac3", "gene_names_refseq": "Hdac3", "protein_names_uniprotkb": "Histone deacetylase 3; 3.5.1.-; 3.5.1.98; HD3; Protein deacetylase HDAC3; Protein deacylase HDAC3", "protein_names_refseq": "HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; histone deacetylase 3; protein deacetylase HDAC3; protein deacylase HDAC3", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrahepatic cholestasis of pregnancy (Disease Ontology:DOID:0070227); prostate carcinoma (Disease Ontology:DOID:10286); impotence (Disease Ontology:DOID:1875); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:15183); (R-MMU-350054); (R-MMU-381340); (R-MMU-400206); (R-MMU-9029569); (R-MMU-9701898); (R-MMU-9707564); (R-MMU-9841922)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "10491319;10984530;11022042;11533236;12130660;15711539;16326862;16537907;19037247;19204783;20675388;21750661;23911289;25875095;26776516;27798112;30279482;30455454", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:23911289, PubMed:30279482). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity (PubMed:23911289). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:19204783). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (PubMed:26776516). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (PubMed:26776516). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247). Also functions as deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3 (By similarity). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (By similarity). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl), 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) and isonicotinyl acyl groups from lysine residues, leading to protein decrotonylation, delactylation, de-2-hydroxyisobutyrylation and deisonicotinylation, respectively (PubMed:30279482). Catalyzes decrotonylation of MAPRE1/EB1 (By similarity). Mediates delactylation NBN/NBS1, thereby inhibiting DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88896;Q3UM33", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O88895-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHK6-1", "uniprot_id": [ { "id": "SLAF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHK6", "type": "external" } ], "mass": 37187.0, "length": 333, "protein_name": "SLAM family member 7", "gene_name": "Slamf7", "organism": "Mouse", "refseq_name": "SLAM family member 7 isoform 1 precursor", "refseq_ac": [ { "id": "NP_653122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653122", "type": "external" } ], "gene_names_uniprotkb": "Slamf7", "gene_names_refseq": "19A24; 19A; 4930560D03Rik; CRACC; CS1; Slamf7", "protein_names_uniprotkb": "SLAM family member 7; Leukocyte cell-surface antigen; Novel Ly9", "protein_names_refseq": "SLAM family member 7 isoform 1 precursor; leukocyte cell-surface antigen; novel Ly9", "tax_id": 10090, "disease": "", "pathway": " (mmu:75345); (R-MMU-198933)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12242590;17981603;19151721;19648922;21750661;21913724;24098802;26495903;26740625;28011936;34428180;36749634;37971565", "class_list": "", "function": "2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review] Review article Publication Status: Online-Only, [RefSeq, PubMed]; CRACC was a critical positive regulator of NK cell function mediated by EAT-2., [RefSeq, PubMed]; SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis., [RefSeq, PubMed]; SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (By similarity). Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (PubMed:19151721). May play a role in lymphocyte adhesion (By similarity). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTL2;Q8CJ63;Q8CJ64;Q8CJ65;Q91XA0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0042110 T cell activation;GO:0002250 adaptive immune response;GO:0032814 regulation of natural killer cell activation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHK6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88384-1", "uniprot_id": [ { "id": "VTI1B_MOUSE", "url": "https://www.uniprot.org/uniprot/O88384", "type": "external" } ], "mass": 26713.0, "length": 232, "protein_name": "Vesicle transport through interaction with t-SNAREs homolog 1B", "gene_name": "Vti1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vti1b; Vti1l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-114608)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11786915;15363411;19144319;21750661;29187734;9553086", "class_list": "", "function": "SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:11786915, PubMed:15363411). On late endosomes, regulates trafficking from late endosomes to the lysosome (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:1903076 regulation of protein localization to plasma membrane;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88384-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VW5-1", "uniprot_id": [ { "id": "GOGA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VW5", "type": "external" } ], "mass": 257564.0, "length": 2238, "protein_name": "Golgin subfamily A member 4", "gene_name": "Golga4", "organism": "Mouse", "refseq_name": "golgin subfamily A member 4 isoform 1", "refseq_ac": [ { "id": "NP_061218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061218", "type": "external" } ], "gene_names_uniprotkb": "Golga4", "gene_names_refseq": "Golga4; Olp-1", "protein_names_uniprotkb": "Golgin subfamily A member 4; tGolgin-1", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 4; golgin subfamily A member 4 isoform 1; golgin subfamily A member 4; golgin-245; tGolgin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54214); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12162805;17242355;18308930;21183079;21750661;25428506;29084197;32736686;34428180", "class_list": "", "function": "Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development., [RefSeq, PubMed]; GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice., [RefSeq, PubMed]; Golgin-245 is a key regulator of TNF secretion; LPS activation of macrophages results in increased Golgi carriers for export, up-regulating the transport pathway for TNF export., [RefSeq, PubMed]; Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70365;Q8CGH6", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0045773 positive regulation of axon extension;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91VW5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25801-1", "uniprot_id": [ { "id": "RBTN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P25801", "type": "external" } ], "mass": 18340.0, "length": 158, "protein_name": "Rhombotin-2", "gene_name": "Lmo2", "organism": "Mouse", "refseq_name": "rhombotin-2 isoform 3", "refseq_ac": [ { "id": "NP_001135808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135808", "type": "external" } ], "gene_names_uniprotkb": "Lmo2; Rbtn-2; Rbtn2; Rhom-2", "gene_names_refseq": "Lmo2; Rbtn-2; Rbtn2; Rhom-2; Ttg2", "protein_names_uniprotkb": "Rhombotin-2; Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2", "protein_names_refseq": "LIM domain only protein 2; LIM only 2; LMO-2; T-cell translocation protein 2; cysteine-rich protein TTG-2; rhombotin-2 isoform 3; rhombotin-2", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:16909); (R-MMU-8939236)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12727888;2034676;21750661;34428180;36210013;36920307;9001422;9391090", "class_list": "", "function": "Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045647 negative regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P25801-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149L7-1", "uniprot_id": [ { "id": "CRTAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149L7", "type": "external" } ], "mass": 43907.0, "length": 393, "protein_name": "Cytotoxic and regulatory T-cell molecule", "gene_name": "Crtam", "organism": "Mouse", "refseq_name": "cytotoxic and regulatory T-cell molecule isoform 1 precursor", "refseq_ac": [ { "id": "NP_001268883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268883", "type": "external" } ], "gene_names_uniprotkb": "Crtam", "gene_names_refseq": "Crtam", "protein_names_uniprotkb": "Cytotoxic and regulatory T-cell molecule; Class-I MHC-restricted T-cell-associated molecule", "protein_names_refseq": "class I-restricted T cell-associated molecule; class-I MHC-restricted T-cell-associated molecule; cytotoxic and regulatory T-cell molecule isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:54698); (R-MMU-198933)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10811014;15781451;15811952;18329370;19752223;21750661;24687959;26694968;31312200;33233764;35820727", "class_list": "", "function": "Class I-restricted T cell-associated molecule (CRTAM) expression on T cells is required for an optimal IL-17 production during Toxoplasma gondii infection. Publication Status: Online-Only, [RefSeq, PubMed]; During pathogenic infection, Crtam-Cadm1 interactions regulate the dynamic equilibrium between newly formed CD4(+) T cells and their retention in the gut., [RefSeq, PubMed]; Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (PubMed:15811952, PubMed:18329370, PubMed:19752223, PubMed:24687959). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (PubMed:18329370). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (PubMed:19752223). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (PubMed:18329370). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (PubMed:19752223). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2, [RefSeq, PubMed]; Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system, [RefSeq, PubMed]; These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WPL6;M0QWH9;Q3TQA9;Q9CVZ9;Q9Z151", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001772 immunological synapse;GO:0016020 membrane", "go_biological_process": "GO:0001819 positive regulation of cytokine production;GO:0002250 adaptive immune response;GO:0045580 regulation of T cell differentiation;GO:0032729 positive regulation of type II interferon production;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q149L7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VAA2-1", "uniprot_id": [ { "id": "CDV3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VAA2", "type": "external" } ], "mass": 29729.0, "length": 281, "protein_name": "Protein CDV3", "gene_name": "Cdv3", "organism": "Mouse", "refseq_name": "protein CDV3 isoform a", "refseq_ac": [ { "id": "NP_780774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780774", "type": "external" } ], "gene_names_uniprotkb": "Cdv3", "gene_names_refseq": "2510010F10Rik; C230084J24Rik; Cdv3; TPP36", "protein_names_uniprotkb": "Protein CDV3; Carnitine deficiency-associated protein 3; TPP36; Tyrosine-phosphorylated protein 36", "protein_names_refseq": "carnitine deficiency-associated protein 3; carnitine deficiency-associated protein CDV3A; carnitine deficiency-associated protein CDV3B; protein CDV3 isoform a; protein CDV3; tyrosine-phosphorylated protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:321022)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12359334;12606058;15592455;17947660;19131326;21750661;22517741;26192747;30084848;32848054;34428180;36852467;37828378;40885482", "class_list": "", "function": "Identification and characterization of novel transcripts that may be involved in the development of cardiac hypertrophy caused by carnitine deficiency(carnitine deficiency-associated gene expressed in ventricle (CDV)- 3), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6L7;Q920C7;Q920I4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q4VAA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHK1-1", "uniprot_id": [ { "id": "CSKI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHK1", "type": "external" } ], "mass": 126779.0, "length": 1201, "protein_name": "Caskin-2", "gene_name": "Caskin2", "organism": "Mouse", "refseq_name": "caskin-2", "refseq_ac": [ { "id": "NP_542374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542374", "type": "external" } ], "gene_names_uniprotkb": "Caskin2; Kiaa1139", "gene_names_refseq": "1600028L06Rik; Caskin2; mKIAA1139", "protein_names_uniprotkb": "Caskin-2", "protein_names_refseq": "caskin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:140721)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12040031;17242355;21183079;21750661;29237092;31727973;34428180;35820727;36852467", "class_list": "", "function": "Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1ATA2;Q6ZPX1;Q7TS77", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VHK1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZA1-1", "uniprot_id": [ { "id": "CPZIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZA1", "type": "external" } ], "mass": 44114.0, "length": 412, "protein_name": "CapZ-interacting protein", "gene_name": "Rcsd1", "organism": "Mouse", "refseq_name": "capZ-interacting protein isoform b", "refseq_ac": [ { "id": "NP_001033935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033935", "type": "external" } ], "gene_names_uniprotkb": "Rcsd1; Capzip", "gene_names_refseq": "A430105K13Rik; CapZIP; Gm19627; Rcsd1", "protein_names_uniprotkb": "CapZ-interacting protein; Protein kinase substrate CapZIP", "protein_names_refseq": "capZ-interacting protein isoform b; capz-interacting protein; protein kinase substrate CapZIP", "tax_id": 10090, "disease": "", "pathway": " (mmu:226594)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;26495903;26740625;29187734;36288343", "class_list": "", "function": "Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAD8;Q3TBC2;Q3TGA5;Q8R3A0", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:1901981 phosphatidylinositol phosphate binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0071203 WASH complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0036010 protein localization to endosome;GO:0042147 retrograde transport, endosome to Golgi;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UZA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JX3-1", "uniprot_id": [ { "id": "GORS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JX3", "type": "external" } ], "mass": 47038.0, "length": 451, "protein_name": "Golgi reassembly-stacking protein 2", "gene_name": "Gorasp2", "organism": "Mouse", "refseq_name": "Golgi reassembly-stacking protein 2", "refseq_ac": [ { "id": "NP_081628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081628", "type": "external" } ], "gene_names_uniprotkb": "Gorasp2", "gene_names_refseq": "0610011A07Rik; 2410043M02Rik; 5730520M13Rik; 9430094F20Rik; GOLPH2; GRASP55; GRS2; Gorasp2; p59", "protein_names_uniprotkb": "Golgi reassembly-stacking protein 2; GRASP55; GRS2; Golgi reassembly-stacking protein of 55 kDa", "protein_names_refseq": "Golgi reassembly-stacking protein 2; golgi reassembly-stacking protein of 55 kDa", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:70231); (R-MMU-162658)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10487747;11739401;17242355;21183079;21750661;22068051;22517741;25428506;26495903;28011936;28049725;28617811;30059200;32229537;32573693;32848054;34428180;34678516;35822049;35984892;37453647;37828378;39927985;40885482;40997131", "class_list": "", "function": "GRASP55 Is Dispensable for Normal Hematopoiesis but Necessary for Myc-Dependent Leukemic Growth., [RefSeq, PubMed]; GRASP55 responds to inflammasome stimulation,controls autophagy initiation and important for secretion of IL-1b and IL-18 Publication Status: Online-Only, [RefSeq, PubMed]; Key structural protein of the Golgi apparatus (PubMed:32573693). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693). However, other studies suggest that GORASP2 plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (By similarity). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (PubMed:28617811). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The function of GORASPs in Golgi apparatus organization in vivo. Erratum:[J Cell Biol. 2020 Sep 7;219(9):jcb.20200419106242020c. doi: 10.1083/jcb.20200419106242020c. PMID: 32589188], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9D2;Q8CCD0;Q91W68", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007030 Golgi organization;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q99JX3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDV6-1", "uniprot_id": [ { "id": "CCD63_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDV6", "type": "external" } ], "mass": 65274.0, "length": 558, "protein_name": "Coiled-coil domain-containing protein 63", "gene_name": "Ccdc63", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 63 isoform 1", "refseq_ac": [ { "id": "NP_001276738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276738", "type": "external" } ], "gene_names_uniprotkb": "Ccdc63", "gene_names_refseq": "4921511C16Rik; Ccdc63", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 63", "protein_names_refseq": "coiled-coil domain-containing protein 63 isoform 1; coiled-coil domain-containing protein 63", "tax_id": 10090, "disease": "", "pathway": " (mmu:330188)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;26501274;30031227;31219806", "class_list": "", "function": "Plays a role in spermiogenesis (PubMed:26501274). Involved in the elongation of flagella and the formation of sperm heads (PubMed:26501274)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF78", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "GO:0007286 spermatid development;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CDV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SJQ7-1", "uniprot_id": [ { "id": "CLM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6SJQ7", "type": "external" } ], "mass": 36715.0, "length": 337, "protein_name": "CMRF35-like molecule 1", "gene_name": "Cd300lf", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001162624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162624", "type": "external" } ], "gene_names_uniprotkb": "Cd300lf; Clm1; Lmir3", "gene_names_refseq": "CLIM1; CLM-1; CLM1; Cd300lf; Digr2; F730004D16Rik; IREM1; IgSF13; LMIR3; Pigr3", "protein_names_uniprotkb": "CMRF35-like molecule 1; CD300 antigen-like family member F; CLM-1; Leukocyte mono-Ig-like receptor 3; MAIR-5; MAIR-V; Myeloid-associated immunoglobulin-like receptor 5", "protein_names_refseq": "CD300 antigen like family member F; CMRF-35-like molecule 1; CMRF35-like molecule 1 isoform 1 precursor; CMRF35-like molecule 1; DC-derived Ig-like receptor 2; MAIR-5; MAIR-V; leukocyte mono-Ig-like receptor 3; myeloid-associated immunoglobulin-like receptor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:246746); (R-MMU-198933)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14662855;16794255;17438331;18097021;21750661;21865548;23123064;26124135;26768664;27540007;27681626;30194229;34001919;35820727", "class_list": "", "function": "(Microbial infection) Acts as a functional receptor for murine norovirus (MNV). Mediates binding to the cell surface and is both necessary and sufficient for viral entry and replication (PubMed:27540007, PubMed:27681626, PubMed:30194229). This interaction requires Mg(2+) and Ca(2+) and is enhanced by bile acids (PubMed:30194229). Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27540007, PubMed:27681626)., [UniProtKB, PubMed, PubMed, PubMed]; Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:17438331). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells (PubMed:21865548). Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (PubMed:26768664). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand (PubMed:23123064). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (PubMed:26124135). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity). Inhibits osteoclast formation (PubMed:14662855). Induces macrophage cell death upon engagement (PubMed:18097021)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; DIgR2 is a functionally inhibitory receptor and can mediate negative signaling to regulate DC-initiated antigen-specific T-cell responses., [RefSeq, PubMed]; Increased hippocampal excitability in miR-324-null mice. Publication Status: Online-Only, [RefSeq, PubMed]; The innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4, [RefSeq, PubMed]; These results indicate that CD300LF mediates caspase and endoplasmic reticulum stress-independent cell death by a novel mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6Z1;A2A6Z3;Q6PEU7;Q8K4V9", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding;GO:0097001 ceramide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0035772 interleukin-13-mediated signaling pathway;GO:1902216 positive regulation of interleukin-4-mediated signaling pathway;GO:2000426 negative regulation of apoptotic cell clearance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6SJQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RTF1-1", "uniprot_id": [ { "id": "CTSRB_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RTF1", "type": "external" } ], "mass": 126108.0, "length": 1109, "protein_name": "Cation channel sperm-associated auxiliary subunit beta", "gene_name": "Catsperb", "organism": "Mouse", "refseq_name": "cation channel sperm-associated auxiliary subunit beta precursor", "refseq_ac": [ { "id": "NP_766611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766611", "type": "external" } ], "gene_names_uniprotkb": "Catsperb", "gene_names_refseq": "4931410B03; 4932415G16Rik; Catsperb", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit beta; CatSper-beta", "protein_names_refseq": "CatSper channel subunit beta; catSper-beta; cation channel sperm-associated auxiliary subunit beta precursor; cation channel sperm-associated protein subunit beta; cation channel, sperm-associated, beta; catsper channel auxiliary subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:271036); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17478420;19516020;21224844;21750661;31219806;34225353;34428180;34998468", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:17478420, PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:17478420)., [UniProtKB, PubMed, PubMed]; CatSperbeta protein is absent in CatSper1(-/-) sperm, suggesting that it is required for trafficking or formation of a stable channel complex, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0R2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005929 cilium;GO:0097228 sperm principal piece;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "A2RTF1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64261-1", "uniprot_id": [ { "id": "CDK6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64261", "type": "external" } ], "mass": 37028.0, "length": 326, "protein_name": "Cyclin-dependent kinase 6", "gene_name": "Cdk6", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 6", "refseq_ac": [ { "id": "NP_034003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034003", "type": "external" } ], "gene_names_uniprotkb": "Cdk6; Cdkn6; Crk2", "gene_names_refseq": "Cdk6; Crk2", "protein_names_uniprotkb": "Cyclin-dependent kinase 6; 2.7.11.22; CR2 protein kinase; CRK2; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE", "protein_names_refseq": "CR2 protein kinase; cell division protein kinase 6; cyclin-dependent kinase 6; serine/threonine-protein kinase PLSTIRE", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); primary autosomal recessive microcephaly 12 (Disease Ontology:DOID:0070284); intellectual disability (Disease Ontology:DOID:1059); cystinosis (Disease Ontology:DOID:1064); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); non-functioning pancreatic endocrine tumor (Disease Ontology:DOID:7698); encephalitis (Disease Ontology:DOID:9588)", "pathway": " (mmu:12571); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-69231); (R-MMU-8934593); (R-MMU-9754119)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10384057;1459009;15315761;16479539;16767702;21183079;21319271;21508411;21750661;23918663;30084848;31219806;34428180;38684032;8444355", "class_list": "", "function": "Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans (By similarity). May play a role in the centrosome organization during the cell cycle phases., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1D2;Q9R1D3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0098770 FBXO family protein binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q64261-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03137-1", "uniprot_id": [ { "id": "EPHA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03137", "type": "external" } ], "mass": 109814.0, "length": 986, "protein_name": "Ephrin type-A receptor 4", "gene_name": "Epha4", "organism": "Mouse", "refseq_name": "ephrin type-A receptor 4 precursor", "refseq_ac": [ { "id": "NP_031962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031962", "type": "external" } ], "gene_names_uniprotkb": "Epha4; Sek1; Sek", "gene_names_refseq": "2900005C20Rik; Cek8; Epha4; Hek8; Sek1; Sek; Tyro1; rb", "protein_names_uniprotkb": "Ephrin type-A receptor 4; 2.7.10.1; Tyrosine-protein kinase receptor MPK-3; Tyrosine-protein kinase receptor SEK-1", "protein_names_refseq": "ephrin type-A receptor 4 precursor; ephrin type-A receptor 4; tyrosine-protein kinase receptor MPK-3; tyrosine-protein kinase receptor SEK-1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); toxic encephalopathy (Disease Ontology:DOID:3602)", "pathway": " (mmu:13838); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11336673;1281307;14516691;15537875;16802330;16818734;17143272;17719550;17785183;18034455;18094260;18403711;21750661;24658113;27446912;30639848;30899004;31439799;31814004;33300544;8622893;9789074", "class_list": "", "function": "Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity (PubMed:17719550). Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (PubMed:17719550, PubMed:17785183, PubMed:9789074). May also control the segregation of motor and sensory axons during neuromuscular circuit developmen (PubMed:18403711). In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis (PubMed:17143272). In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation (PubMed:15537875, PubMed:16802330). Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium (PubMed:16818734). During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (PubMed:30639848). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (PubMed:31439799)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80VZ2", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0050770 regulation of axonogenesis;GO:0060384 innervation;GO:0097485 neuron projection guidance;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q03137-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64314-1", "uniprot_id": [ { "id": "CD34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64314", "type": "external" } ], "mass": 40983.0, "length": 382, "protein_name": "Hematopoietic progenitor cell antigen CD34", "gene_name": "Cd34", "organism": "Mouse", "refseq_name": "hematopoietic progenitor cell antigen CD34 isoform 2 precursor", "refseq_ac": [ { "id": "NP_598415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598415", "type": "external" } ], "gene_names_uniprotkb": "Cd34", "gene_names_refseq": "Cd34", "protein_names_uniprotkb": "Hematopoietic progenitor cell antigen CD34", "protein_names_refseq": "cluster designation 34; hematopoietic progenitor cell antigen CD34 isoform 2 precursor; hematopoietic progenitor cell antigen CD34", "tax_id": 10090, "disease": "thyroid gland carcinoma (Disease Ontology:DOID:3963); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:12490); (R-MMU-198933)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;1373970;15592455;1709048;17947660;19656770;21183079;21750661;25428506;31605441;34428180;36288343", "class_list": "glycogene", "function": "Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q62550;Q62551", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0043199 sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0007165 signal transduction;GO:0010629 negative regulation of gene expression;GO:0001894 tissue homeostasis;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q64314-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C6KI89-1", "uniprot_id": [ { "id": "CTSG2_MOUSE", "url": "https://www.uniprot.org/uniprot/C6KI89", "type": "external" } ], "mass": 131417.0, "length": 1145, "protein_name": "Cation channel sperm-associated auxiliary subunit gamma 2", "gene_name": "Catsperg2", "organism": "Mouse", "refseq_name": "cation channel sperm-associated auxiliary subunit gamma 2 precursor", "refseq_ac": [ { "id": "NP_083990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083990", "type": "external" } ], "gene_names_uniprotkb": "Catsperg2; Catsperg", "gene_names_refseq": "1700067C01Rik; CATSPERG; Catsperg2", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit gamma 2", "protein_names_refseq": "CATSPER gamma subunit protein; cation channel sperm-associated auxiliary subunit gamma 2 precursor; cation channel sperm-associated protein subunit gamma 2; cation channel, sperm-associated, gamma 2; catsper channel auxiliary subunit gamma 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76718)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19516020;21224844;21750661;34225353", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:19516020, PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:19516020)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0031514 motile cilium;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "C6KI89-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K389-1", "uniprot_id": [ { "id": "CK5P2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K389", "type": "external" } ], "mass": 205945.0, "length": 1822, "protein_name": "CDK5 regulatory subunit-associated protein 2", "gene_name": "Cdk5rap2", "organism": "Mouse", "refseq_name": "CDK5 regulatory subunit-associated protein 2 isoform 1", "refseq_ac": [ { "id": "NP_666102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666102", "type": "external" } ], "gene_names_uniprotkb": "Cdk5rap2; Kiaa1633", "gene_names_refseq": "2900018K03Rik; Cdk5rap2; an; mKIAA1633", "protein_names_uniprotkb": "CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48", "protein_names_refseq": "CDK5 activator-binding protein C48; CDK5 regulatory subunit-associated protein 2 isoform 1", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); primary autosomal recessive microcephaly 3 (Disease Ontology:DOID:0070286); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:214444); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "19144319;19553473;20460369;20466722;20471352;20627074;21183079;21750661;30084848;31219806;34203471;34428180;35820727;36210013;39137170", "class_list": "", "function": "Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to regulate cortical development via microtubule organization. Publication Status: Online-Only, [RefSeq, PubMed]; Potential regulator of CDK5 activity via its interaction with CDK5R1 (By similarity). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion (PubMed:20627074). Involved in regulation of mitotic spindle orientation (PubMed:20460369). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (By similarity). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (By similarity). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (By similarity). Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (PubMed:20471352). Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear (PubMed:19553473)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVA1;Q6PCN1;Q6ZPL0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007059 chromosome segregation;GO:0045665 negative regulation of neuron differentiation;GO:0007420 brain development;GO:0045893 positive regulation of DNA-templated transcription;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K389-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24807-1", "uniprot_id": [ { "id": "CD24_MOUSE", "url": "https://www.uniprot.org/uniprot/P24807", "type": "external" } ], "mass": 7797.0, "length": 76, "protein_name": "Signal transducer CD24", "gene_name": "Cd24a; Cd24", "organism": "Mouse", "refseq_name": "signal transducer CD24 isoform 2 precursor", "refseq_ac": [ { "id": "NP_033976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033976", "type": "external" } ], "gene_names_uniprotkb": "Cd24a; Cd24; Cd24a; Ly-52", "gene_names_refseq": "Cd24a; Cd24; HSA; Ly-52; nectadrin", "protein_names_uniprotkb": "Signal transducer CD24; HSA; Ly-52; Lymphocyte antigen 52; M1/69-J11D heat stable antigen; Nectadrin; R13-Ag; X62 heat stable antigen", "protein_names_refseq": "M1/69-J11D heat stable antigen; R13-Ag; X62 heat stable antigen; cluster of differentiation 24; lymphocyte antigen 52; signal transducer CD24 isoform 2 precursor; signal transducer CD24", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:12484)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1530634;19264983;2019286;20200274;2118158;21750661;38462024;8226859", "class_list": "", "function": "May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (By similarity). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983). Plays a role in the control of autoimmunity (PubMed:20200274)., [UniProtKB, UniProtKB, PubMed, PubMed]; Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 4, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P26691", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030246 carbohydrate binding;GO:0030296 protein tyrosine kinase activator activity;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0016477 cell migration;GO:0045087 innate immune response;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P24807-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88693-1", "uniprot_id": [ { "id": "CEGT_MOUSE", "url": "https://www.uniprot.org/uniprot/O88693", "type": "external" } ], "mass": 44839.0, "length": 394, "protein_name": "Ceramide glucosyltransferase", "gene_name": "Ugcg", "organism": "Mouse", "refseq_name": "ceramide glucosyltransferase", "refseq_ac": [ { "id": "NP_035803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035803", "type": "external" } ], "gene_names_uniprotkb": "Ugcg", "gene_names_refseq": "Epcs21; GlcT-1; Ugcgl; Ugcg", "protein_names_uniprotkb": "Ceramide glucosyltransferase; 2.4.1.80; GCS; GLCT-1; Glucosylceramide synthase; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase", "protein_names_refseq": "GCS; UDP-glucose:N-acylsphingosine D-glucosyltransferase; ceramide glucosyltransferase; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21; glucosylceramide synthase; glycosylceramide synthase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:22234); (R-MMU-9840309)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10430909;12417405;16109770;17145749;20432257;20544855;22851168;23554574;23576753;23748427;26495903;26740625;28011936;28373486;31209405;31599954;33361282;34428180;35168060;37004877;9623774;9918791", "class_list": "glycogene;glycosyltransferase", "function": "Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease., [RefSeq, PubMed]; Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides., [RefSeq, PubMed]; Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:10430909, PubMed:16109770, PubMed:28373486). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:10430909). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction (PubMed:10430909). They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (PubMed:10430909). They are required for instance in the proper development and functioning of the nervous system (PubMed:16109770). As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (PubMed:23554574). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (PubMed:17145749, PubMed:23748427). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (PubMed:22851168). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (PubMed:33361282)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AN90", "ec_number_list": [ { "id": "2.4.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.80", "type": "external" } ], "go_molecular_function": "GO:0008120 ceramide glucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0061436 establishment of skin barrier;GO:0030216 keratinocyte differentiation;GO:0006497 protein lipidation;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O88693-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY96-1", "uniprot_id": [ { "id": "CASR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY96", "type": "external" } ], "mass": 120903.0, "length": 1079, "protein_name": "Extracellular calcium-sensing receptor", "gene_name": "Casr", "organism": "Mouse", "refseq_name": "extracellular calcium-sensing receptor precursor", "refseq_ac": [ { "id": "NP_038831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038831", "type": "external" } ], "gene_names_uniprotkb": "Casr; Gprc2a", "gene_names_refseq": "CaR; Casr; Gprc2a", "protein_names_uniprotkb": "Extracellular calcium-sensing receptor; CaSR; PCaR1; Parathyroid cell calcium-sensing receptor", "protein_names_refseq": "G protein-coupled receptor, family C, group 2, member A; PCaR1; cation sensing receptor; extracellular calcium-sensing receptor precursor; extracellular calcium-sensing receptor; parathyroid cell calcium-sensing receptor", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); familial hypocalciuric hypercalcemia 1 (Disease Ontology:DOID:0060700); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia 1 (Disease Ontology:DOID:0090107); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); intellectual disability (Disease Ontology:DOID:1059); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hypercalcemia (Disease Ontology:DOID:12678); hyperparathyroidism (Disease Ontology:DOID:13543); atherosclerosis (Disease Ontology:DOID:1936); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:12374); (R-MMU-416476); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10579354;10625662;10652312;12671051;15347804;21183079;23143333;25428506;26261299;38314127;38386045;39146692;7493018;9076582", "class_list": "", "function": "A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects., [RefSeq, PubMed]; Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice., [RefSeq, PubMed]; G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:23143333). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (PubMed:7493018). In kidneys, acts as a key regulator of renal tubular calcium resorption (PubMed:12671051). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G proteins depending on the context (PubMed:23143333). In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity (PubMed:23143333). The G protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity). Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (PubMed:23143333). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (PubMed:26261299)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "G3UX06;O08968;O88519;Q9QY95;Q9QZU8;Q9R1D6;Q9R1Y2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0002931 response to ischemia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9QY96-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27548-1", "uniprot_id": [ { "id": "CD40L_MOUSE", "url": "https://www.uniprot.org/uniprot/P27548", "type": "external" } ], "mass": 29370.0, "length": 260, "protein_name": "CD40 ligand", "gene_name": "Cd40lg", "organism": "Mouse", "refseq_name": "CD40 ligand", "refseq_ac": [ { "id": "NP_035746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035746", "type": "external" } ], "gene_names_uniprotkb": "Cd40lg; Cd40l; Tnfsf5", "gene_names_refseq": "CD154; CD40-L; Cd40lg; Cd40l; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; TRAP; Tnfsf5; Tnlg8b; gp39", "protein_names_uniprotkb": "CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5", "protein_names_refseq": "CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5", "tax_id": 10090, "disease": "cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); tick-borne encephalitis (Disease Ontology:DOID:0050175); erythema multiforme (Disease Ontology:DOID:0050185); inflammatory bowel disease (Disease Ontology:DOID:0050589); vitamin B12 deficiency (Disease Ontology:DOID:0050731); follicular lymphoma (Disease Ontology:DOID:0050873); CD40 ligand deficiency (Disease Ontology:DOID:0060022); thrombosis (Disease Ontology:DOID:0060903); overactive bladder syndrome (Disease Ontology:DOID:0070355); lupus nephritis (Disease Ontology:DOID:0080162); dermatomyositis (Disease Ontology:DOID:10223); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); sickle cell anemia (Disease Ontology:DOID:10923); familial hyperlipidemia (Disease Ontology:DOID:1168); dysgammaglobulinemia (Disease Ontology:DOID:11702); diabetic angiopathy (Disease Ontology:DOID:11713); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); cardiovascular system disease (Disease Ontology:DOID:1287); Sjogren's syndrome (Disease Ontology:DOID:12894); HELLP syndrome (Disease Ontology:DOID:13133); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); eosinophilic esophagitis (Disease Ontology:DOID:13922); cystic fibrosis (Disease Ontology:DOID:1485); atherosclerosis (Disease Ontology:DOID:1936); essential thrombocythemia (Disease Ontology:DOID:2224); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); Ehrlich tumor carcinoma (Disease Ontology:DOID:5050); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); combined T cell and B cell immunodeficiency (Disease Ontology:DOID:628); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); periodontitis (Disease Ontology:DOID:824); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); narcolepsy (Disease Ontology:DOID:8986); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21947); (R-MMU-198933); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1374165;1377364;7520529;8095800", "class_list": "", "function": "Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling., [UniProtKB, UniProtKB]; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (PubMed:1374165). Involved in immunoglobulin class switching (PubMed:1374165)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005125 cytokine activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0005174 CD40 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:2001200 positive regulation of dendritic cell differentiation;GO:0002637 regulation of immunoglobulin production;GO:0023035 CD40 signaling pathway;GO:0006954 inflammatory response;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27548-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH18-1", "uniprot_id": [ { "id": "CCAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CH18", "type": "external" } ], "mass": 132060.0, "length": 1146, "protein_name": "Cell division cycle and apoptosis regulator protein 1", "gene_name": "Ccar1", "organism": "Mouse", "refseq_name": "cell division cycle and apoptosis regulator protein 1 isoform a", "refseq_ac": [ { "id": "NP_080477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080477", "type": "external" } ], "gene_names_uniprotkb": "Ccar1; Carp1", "gene_names_refseq": "2610511G16Rik; 9430036H15Rik; Carp1; Ccar1", "protein_names_uniprotkb": "Cell division cycle and apoptosis regulator protein 1; CARP-1; Cell cycle and apoptosis regulatory protein 1", "protein_names_refseq": "CARP-1; cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator protein 1 isoform a; cell division cycle and apoptosis regulator protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67500)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18722177;21750661;23887938;24245781;24811171;29125738;31599954;34428180;34887587;39627609;40997131", "class_list": "", "function": "Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938)., [UniProtKB, PubMed, PubMed, UniProtKB]; CCAR1 and CoCoA are a bypass between GATA1 and the MED1 subunit of Mediator Erratum:[Genes Cells. 2023 Jan;28(1):78. doi: 10.1111/gtc.12991. PMID: 36647803], [RefSeq, PubMed]; Depletion of CCAR1 compromised adipogenesis in cell culture and GR-mediated chromatin remodeling of PPARgamma gene enhancer elements., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05BR1;Q05DK6;Q6AXC9;Q6PAR2;Q80XE4;Q8BJY0;Q8BVN2;Q8CGG1;Q9CSR5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043065 positive regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CH18-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIG7-1", "uniprot_id": [ { "id": "CCD22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIG7", "type": "external" } ], "mass": 70844.0, "length": 627, "protein_name": "Coiled-coil domain-containing protein 22", "gene_name": "Ccdc22", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 22", "refseq_ac": [ { "id": "NP_613069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613069", "type": "external" } ], "gene_names_uniprotkb": "Ccdc22; DXImx40e", "gene_names_refseq": "Ccdc22; DXImx40e; Ppp1r3f; Sfc22", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 22", "protein_names_refseq": "coiled-coil domain-containing protein 22", "tax_id": 10090, "disease": "Ritscher-Schinzel syndrome 2 (Disease Ontology:DOID:0060572)", "pathway": " (mmu:54638); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10857745;12522145;22872234;26495903;31219806;34428180;36210013", "class_list": "", "function": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (By similarity). Involved in regulation of NF-kappa-B signaling (By similarity). Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex (By similarity). May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (By similarity). Plays a role in copper ion homeostasis (By similarity). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (By similarity)., [UniProtKB, UniProtKB]; Identifies this protein as a copine-binding protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVA1;Q8BYH4", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005813 centrosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0097006 regulation of plasma lipoprotein particle levels;GO:0006878 intracellular copper ion homeostasis;GO:0015031 protein transport;GO:0042632 cholesterol homeostasis;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JIG7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06745-1", "uniprot_id": [ { "id": "G6PI_MOUSE", "url": "https://www.uniprot.org/uniprot/P06745", "type": "external" } ], "mass": 62767.0, "length": 558, "protein_name": "Glucose-6-phosphate isomerase", "gene_name": "Gpi1; Gpi", "organism": "Mouse", "refseq_name": "glucose-6-phosphate isomerase", "refseq_ac": [ { "id": "NP_032181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032181", "type": "external" } ], "gene_names_uniprotkb": "Gpi1; Gpi; Gpi1", "gene_names_refseq": "Amf; Gpi-1r; Gpi-1s; Gpi-1t; Gpi-1; Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; Gpi1; Gpi; MF; NK/GPI; NK; Nlk; Org; Pgi; Phi", "protein_names_uniprotkb": "Glucose-6-phosphate isomerase; 5.1.3.-; 5.3.1.9; AMF; Autocrine motility factor; D-hexose-6-phosphate anomerase; GPI; Glucose-6-phosphate C2-epimerase; NLK; Neuroleukin; PGI; PHI; Phosphoglucose isomerase; Phosphohexose isomerase", "protein_names_refseq": "D-hexose-6-phosphate anomerase; autocrine motility factor; glucose phosphate isomerase 1 complex; glucose phosphate isomerase 1, regulatory; glucose phosphate isomerase 1, structural; glucose phosphate isomerase 1, temporal; glucose-6-phosphate C2-epimerase; glucose-6-phosphate isomerase; maturation factor; neuroleukin; phosphoglucose isomerase; phosphohexose isomerase", "tax_id": 10090, "disease": "congenital nonspherocytic hemolytic anemia 4 (Disease Ontology:DOID:0051005); intellectual disability (Disease Ontology:DOID:1059); heart disease (Disease Ontology:DOID:114); Parkinson's disease (Disease Ontology:DOID:14330); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); neuromuscular disease (Disease Ontology:DOID:440); congenital hemolytic anemia (Disease Ontology:DOID:589); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14751); (R-MMU-5628897); (R-MMU-6798695); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 5, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;15342241;16139798;16375918;21183079;21750661;21952136;22645316;2344351;23806337;26495903;26740625;27802388;28528544;29127146;33300544;3352745;34428180;36288343;36583994;37453647;37507081;3764429;7277315;7545951;8417789;8674049;8922529;9798653", "class_list": "glycogene", "function": "Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P. In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; PGI is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor., [RefSeq, PubMed]; This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O89062;Q3TEE7;Q3TW50;Q3UUX1;Q3UY84;Q3UZJ1;Q5RJI3;Q8C675;Q9JM07", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0004347 glucose-6-phosphate isomerase activity;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0007611 learning or memory;GO:0043066 negative regulation of apoptotic process;GO:0010595 positive regulation of endothelial cell migration;GO:0006094 gluconeogenesis;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P06745-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUK3-1", "uniprot_id": [ { "id": "CLN8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUK3", "type": "external" } ], "mass": 33109.0, "length": 288, "protein_name": "Protein CLN8", "gene_name": "Cln8", "organism": "Mouse", "refseq_name": "protein CLN8", "refseq_ac": [ { "id": "NP_036130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036130", "type": "external" } ], "gene_names_uniprotkb": "Cln8", "gene_names_refseq": "Cln8; Tlcd6; mnd", "protein_names_uniprotkb": "Protein CLN8", "protein_names_refseq": "ceroid-lipofuscinosis, neuronal 8; motor neuron degeneration; protein CLN8", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 8 (Disease Ontology:DOID:0110723); neuronal ceroid lipofuscinosis 8 northern epilepsy variant (Disease Ontology:DOID:0110724)", "pathway": " (mmu:26889)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10508524;19941651;21750661;30397314;32597833", "class_list": "", "function": "A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer. Erratum:[J Clin Invest. 2025 Dec 15;135(24):e202081. doi: 10.1172/JCI202081. PMID: 41392992], [RefSeq, PubMed]; Ceroid-lipofuscinosis neuronal 8 protein (Cln8) knockout strain, which bears an early frameshift mutation in Cln8 that causes CLN8 protein deficiency and features resembling those seen in Batten disease., [RefSeq, PubMed]; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097001 ceramide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0007399 nervous system development;GO:0008203 cholesterol metabolic process;GO:0008306 associative learning;GO:0008344 adult locomotory behavior;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QUK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SV66-1", "uniprot_id": [ { "id": "CCD42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SV66", "type": "external" } ], "mass": 37989.0, "length": 316, "protein_name": "Coiled-coil domain-containing protein 42", "gene_name": "Ccdc42", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 42", "refseq_ac": [ { "id": "NP_808447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808447", "type": "external" } ], "gene_names_uniprotkb": "Ccdc42", "gene_names_refseq": "A530001H01Rik; Ccdc42", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 42", "protein_names_refseq": "coiled-coil domain-containing protein 42A; coiled-coil domain-containing protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:276920)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;26945718;30779550;31475146;34124066;38038747;40885482", "class_list": "", "function": "Data indicate that mutations in the gene Coiled-coil domain containing 42 (Ccdc42) is associated with malformation of the sperm flagella., [RefSeq, PubMed]; Essential for male fertility (PubMed:26945718). Required for sperm development (PubMed:26945718)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EHU2;Q8BNY1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0002177 manchette;GO:0097228 sperm principal piece;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0001675 acrosome assembly;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5SV66-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18581-1", "uniprot_id": [ { "id": "CTR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P18581", "type": "external" } ], "mass": 71856.0, "length": 657, "protein_name": "Cationic amino acid transporter 2", "gene_name": "Slc7a2", "organism": "Mouse", "refseq_name": "cationic amino acid transporter 2 isoform 2", "refseq_ac": [ { "id": "NP_001038205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038205", "type": "external" } ], "gene_names_uniprotkb": "Slc7a2; Atrc2; Tea", "gene_names_refseq": "20.5; Atrc2; CAT-2; Cat2; Slc7a2; Tea", "protein_names_uniprotkb": "Cationic amino acid transporter 2; 20.5; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; T-cell early activation protein; TEA", "protein_names_refseq": "T-cell early activation protein; amino acid transporter, cationic 2 (low affinity); cationic amino acid transporter 2 isoform 2; cationic amino acid transporter 2A; cationic amino acid transporter 2B; low affinity cationic amino acid transporter 2; solute carrier family 7 member 2", "tax_id": 10090, "disease": "proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666)", "pathway": " (mmu:11988)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "16239143;16670299;1694015;18250455;19144319;21183079;21750661;25428506;28642498;30084848;34428180;36572564;38203268;38419038;8195186;8385111;9174363", "class_list": "", "function": "Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine)., [UniProtKB, PubMed, PubMed]; Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:8195186, PubMed:8385111, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (PubMed:16670299)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine than isoform 1., [UniProtKB, PubMed, PubMed]; Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QPL9;Q38RA6;Q3TB99;Q3U3R5", "ec_number_list": [], "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0005289 high-affinity L-arginine transmembrane transporter activity;GO:0005292 high-affinity lysine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0050727 regulation of inflammatory response;GO:1902475 L-alpha-amino acid transmembrane transport;GO:0006809 nitric oxide biosynthetic process;GO:0002537 nitric oxide production involved in inflammatory response;GO:0043030 regulation of macrophage activation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P18581-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9EJA2-1", "uniprot_id": [ { "id": "CTTB2_MOUSE", "url": "https://www.uniprot.org/uniprot/B9EJA2", "type": "external" } ], "mass": 178774.0, "length": 1648, "protein_name": "Cortactin-binding protein 2", "gene_name": "Cttnbp2", "organism": "Mouse", "refseq_name": "cortactin-binding protein 2", "refseq_ac": [ { "id": "NP_525024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525024", "type": "external" } ], "gene_names_uniprotkb": "Cttnbp2; Kiaa1758", "gene_names_refseq": "3010022N24Rik; 4732477G22Rik; 6430526E05; 9130022E09Rik; Cortbp2; Cttnbp2; ORF4; mKIAA1758", "protein_names_uniprotkb": "Cortactin-binding protein 2; CortBP2", "protein_names_refseq": "CTTNBP2 intron retention form; cortactin-binding protein 2 intron retention form; cortactin-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:30785)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22262902;22645316;23015759;24129315;25428506;29187734;31219806;32848054;34678516;35562389;35822049;36210013;40021952;40885482", "class_list": "", "function": "Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance (PubMed:22262902). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons (PubMed:23015759)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "G3X9L7;Q69ZB2;Q8BVG1;Q8C044", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005938 cell cortex;GO:0043197 dendritic spine;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0050807 regulation of synapse organization;GO:1905274 regulation of modification of postsynaptic actin cytoskeleton", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "B9EJA2-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY57-1", "uniprot_id": [ { "id": "CHTOP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY57", "type": "external" } ], "mass": 26585.0, "length": 249, "protein_name": "Chromatin target of PRMT1 protein", "gene_name": "Chtop", "organism": "Mouse", "refseq_name": "chromatin target of PRMT1 protein isoform 1", "refseq_ac": [ { "id": "NP_001280705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280705", "type": "external" } ], "gene_names_uniprotkb": "Chtop; 2500003M10Rik; Fop; MNCb-1706", "gene_names_refseq": "2500003M10Rik; Chtop; Fop; Srag", "protein_names_uniprotkb": "Chromatin target of PRMT1 protein; Friend of PRMT1 protein; SRAG; Small arginine- and glycine-rich protein", "protein_names_refseq": "Friend of PRMT1 protein; chromatin target of PRMT1 protein isoform 1; chromatin target of PRMT1 protein; small arginine- and glycine-rich protein; small protein rich in arginine and glycine", "tax_id": 10090, "disease": "", "pathway": " (mmu:66511); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "19254951;19858291;20688955;21750661;22645316;22872859;25284789;25428506;25605945;29187734;34428180;35820727;38117276", "class_list": "", "function": "CHTOP Promotes Microglia-Mediated Inflammation by Regulating Cell Metabolism and Inflammatory Gene Expression., [RefSeq, PubMed]; Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2)., [RefSeq, PubMed]; Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBG3;Q3U7V6;Q3UF43;Q3V105;Q5XJG9;Q8C5N4;Q9D7T3;Q9DB03;Q9DC54;Q9JJ95", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0000346 transcription export complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0032781 positive regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CY57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TR08-1", "uniprot_id": [ { "id": "FNDC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TR08", "type": "external" } ], "mass": 24933.0, "length": 231, "protein_name": "Fibronectin type III domain-containing protein 4", "gene_name": "Fndc4", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 4 isoform b precursor", "refseq_ac": [ { "id": "NP_071869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071869", "type": "external" } ], "gene_names_uniprotkb": "Fndc4; Fnmp1; Frcp1", "gene_names_refseq": "2810430J06Rik; 6330410H20Rik; FRCP1; Fndc4; Fnmp1", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1", "protein_names_refseq": "fibronectin type III domain-containing protein 4 isoform b precursor; fibronectin type III domain-containing protein 4; fibronectin type III repeat containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64339)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12384288;21750661;27066907;29787756;29977911;32298013;34016966", "class_list": "", "function": "FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10 Publication Status: Online-Only, [RefSeq, PubMed]; Fibronectin type III domain containing four promotes differentiation of C2C12 through the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation (PubMed:27066907). May suppress osteoclastogenesis and mature osteoclast resorptive function (PubMed:29977911). In white adipose tissue, decreases local inflammation, via interaction with GPR116 (PubMed:29787756, PubMed:34016966). Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake (PubMed:29787756, PubMed:34016966). The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling (PubMed:34016966)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q810E5;Q9CYY4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3TR08-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5L3-1", "uniprot_id": [ { "id": "CNOT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5L3", "type": "external" } ], "mass": 59711.0, "length": 540, "protein_name": "CCR4-NOT transcription complex subunit 2", "gene_name": "Cnot2", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 2 isoform a", "refseq_ac": [ { "id": "NP_001032935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032935", "type": "external" } ], "gene_names_uniprotkb": "Cnot2", "gene_names_refseq": "2600016M12Rik; 2810470K03Rik; Cnot2", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2", "protein_names_refseq": "CCR4-NOT transcription complex subunit 2 isoform a; CCR4-associated factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72068); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "21183079;21606357;21750661;22367759;22517741;22645316;24129315;24200330;25605945;26495903;27669760;30059200;31219806;32782141;32848054;34428180;34678516;36852467;40021952;40885482;40997131", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages., [UniProtKB, PubMed]; These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE39;Q80YA5;Q9D0P1", "ec_number_list": [], "go_molecular_function": "GO:0004535 poly(A)-specific ribonuclease activity;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000932 P-body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0001829 trophectodermal cell differentiation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q8C5L3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUU9-1", "uniprot_id": [ { "id": "GANP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUU9", "type": "external" } ], "mass": 217363.0, "length": 1971, "protein_name": "Germinal-center associated nuclear protein", "gene_name": "Mcm3ap", "organism": "Mouse", "refseq_name": "germinal-center associated nuclear protein", "refseq_ac": [ { "id": "NP_062307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062307", "type": "external" } ], "gene_names_uniprotkb": "Mcm3ap; Ganp; Map80", "gene_names_refseq": "GANP; Mcm3ap", "protein_names_uniprotkb": "Germinal-center associated nuclear protein; 2.3.1.48; GANP; GC-associated DNA primase", "protein_names_refseq": "80 kDa MCM3-associated protein; GC-associated DNA primase; germinal-center associated nuclear protein; minichromosome maintenance deficient 3-associated protein; nuclear protein GANP", "tax_id": 10090, "disease": "", "pathway": " (mmu:54387)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10733502;11526238;12167160;12791315;14715907;17903179;20507984;21750661;22645316;23576753;23652018;24129315;24808370;26749495;28541550;32782141;34428180;34678516;36852467;39627609;40885482;40997131", "class_list": "", "function": "As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018)., [UniProtKB, UniProtKB, PubMed]; GANP may serve as an essential link required to transport AID to B-cell nuclei and to target AID to actively transcribed IgV regions, [RefSeq, PubMed]; GANP plays a positive role in IgV region diversification of DT40 B cells in a nonhomologous end joining-proficient state. DNA-PKcs physically interacts with GANP, and this interaction is dissociated by dsDNA breaks, [RefSeq, PubMed]; GANP works to maintain antibody structure by reducing drastic changes in the IgV framework regions in affinity maturation, [RefSeq, PubMed]; GANP(hi)plasma-like cells appear in lymph nodes of autoimmune mice during aging, [RefSeq, PubMed]; GANP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AID targeting., [RefSeq, PubMed]; Interaction with MCM3 is associated with a novel phosphatase component G5PR, [RefSeq, PubMed]; Role in generation or maintenance of B cells with high-affinity B cell antigen receptors during the maturation in germinal centers, [RefSeq, PubMed]; These results indicated that the GANP protein is associated with breast cancer resistance., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q7TS87", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003676 nucleic acid binding;GO:0042393 histone binding;GO:0004402 histone acetyltransferase activity;GO:0010484 histone H3 acetyltransferase activity", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0034728 nucleosome organization;GO:0006406 mRNA export from nucleus;GO:0015031 protein transport;GO:0016446 somatic hypermutation of immunoglobulin genes", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9WUU9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL56-1", "uniprot_id": [ { "id": "GDE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL56", "type": "external" } ], "mass": 37629.0, "length": 331, "protein_name": "Glycerophosphodiester phosphodiesterase 1", "gene_name": "Gde1", "organism": "Mouse", "refseq_name": "glycerophosphodiester phosphodiesterase 1", "refseq_ac": [ { "id": "NP_062526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062526", "type": "external" } ], "gene_names_uniprotkb": "Gde1; Mir16", "gene_names_refseq": "1200003M13Rik; Gde1; Mir16; RGS16", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 1; 3.1.4.-; 3.1.4.44; Glycerophosphoinositol glycerophosphodiesterase GDE1; Lysophospholipase D GDE1; Membrane-interacting protein of RGS16", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 1; glycerophosphoinositol glycerophosphodiesterase GDE1; lysophospholipase D GDE1; membrane interacting protein of RGS16", "tax_id": 10090, "disease": "", "pathway": " (mmu:56209); (R-MMU-6814848)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10760272;12576545;18227059;20393650;20797612;21750661;21801852;25596343;26067236;30899004;34428180;38769369", "class_list": "", "function": "A multistep pathway for the production of anandamide in the nervous system by the sequential actions of Abh4 and GDE1., [RefSeq, PubMed]; Characterization of mice lacking N-acyl ethanolamine biosynthetic enzymes., [RefSeq, PubMed]; Findings designate GroPSer as a previously unappreciated reservoir for free serine in the nervous system and suggest that GDE1, through recycling serine from GroPSer, may impact D-serine-dependent neural signaling processes in vivo, [RefSeq, PubMed]; GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (PubMed:18227059, PubMed:21801852, PubMed:25596343). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic) (PubMed:18227059). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine (PubMed:21801852, PubMed:25596343). However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (PubMed:21801852, PubMed:25596343). Has little or no activity towards glycerophosphocholine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Regulation by by stimulation of G protein-coupled receptors, [RefSeq, PubMed]; The authors confirmed the role of Gde1 in NAFLD by in vivo hepatic over-expression and shRNA knockdown studies. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBU4", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006580 ethanolamine metabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0006644 phospholipid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9JL56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61584-1", "uniprot_id": [ { "id": "FXR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61584", "type": "external" } ], "mass": 76222.0, "length": 677, "protein_name": "RNA-binding protein FXR1", "gene_name": "Fxr1", "organism": "Mouse", "refseq_name": "RNA-binding protein FXR1 isoform 1", "refseq_ac": [ { "id": "NP_001106659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106659", "type": "external" } ], "gene_names_uniprotkb": "Fxr1; Fxr1h", "gene_names_refseq": "1110050J02Rik; 9530073J07Rik; Fxr1h; Fxr1p; Fxr1", "protein_names_uniprotkb": "RNA-binding protein FXR1; FXR1P; mFxr1p", "protein_names_refseq": "RNA-binding protein FXR1 isoform 1; RNA-binding protein FXR1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); congenital myopathy 9A (Disease Ontology:DOID:0081343); congenital myopathy 9B (Disease Ontology:DOID:0081344); fragile X syndrome (Disease Ontology:DOID:14261); glucose metabolism disease (Disease Ontology:DOID:4194); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (mmu:14359)", "pathway_count": 1, "publication_count": 48, "publication_id_list": "10.1101/2023.09.13.557529;10409431;11178106;11438699;15128702;15548538;15592455;16000371;16452087;17242355;17947660;18299400;19224205;20173027;21183079;21750661;21952136;22022532;22645316;24788674;25153642;25428506;25428507;25456134;25605945;26240334;28135057;28204491;28528544;29142209;30770808;30779550;31219806;32328638;32893934;34428180;34887587;35820727;35822049;35951695;36288343;37080662;37083155;37216506;37507081;37828378;40885482;8634689", "class_list": "", "function": "ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation., [RefSeq, PubMed]; FXR1 impedes the development of osteoarthritis by targeting SND1., [RefSeq, PubMed]; Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids., [RefSeq, PubMed]; Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells., [RefSeq, PubMed]; mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:15128702, PubMed:25456134, PubMed:32328638, PubMed:35951695). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:25456134). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:32328638, PubMed:35951695). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (PubMed:35951695). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (By similarity). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (By similarity). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (PubMed:15548538). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (PubMed:25456134). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (PubMed:28204491). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (PubMed:32893934). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:15128702, PubMed:32328638). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (By similarity). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (By similarity). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCU4;Q9R1E2;Q9R1E3;Q9R1E4;Q9R1E5;Q9WUA7;Q9WUA8;Q9WUA9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0043021 ribonucleoprotein complex binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0002183 cytoplasmic translational initiation;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q61584-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97288-1", "uniprot_id": [ { "id": "5HT4R_MOUSE", "url": "https://www.uniprot.org/uniprot/P97288", "type": "external" } ], "mass": 43962.0, "length": 388, "protein_name": "5-hydroxytryptamine receptor 4", "gene_name": "Htr4", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 4 isoform 1", "refseq_ac": [ { "id": "NP_032339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032339", "type": "external" } ], "gene_names_uniprotkb": "Htr4", "gene_names_refseq": "5-HT-4; 5-HT4; 5-HT<4L>; 5HTR4; Htr4", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4", "protein_names_refseq": "5-hydroxytryptamine receptor 4 isoform 1; 5-hydroxytryptamine receptor 4", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (mmu:15562); (R-MMU-390666); (R-MMU-418555)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10220570;15466885;21750661;32870377;37766457;8946946;9928238", "class_list": "", "function": "Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice., [RefSeq, PubMed]; Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity)., [UniProtKB, UniProtKB]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O89003;O89004;Q3URB5;Q9R2A4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97288-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89110-1", "uniprot_id": [ { "id": "CASP8_MOUSE", "url": "https://www.uniprot.org/uniprot/O89110", "type": "external" } ], "mass": 55357.0, "length": 480, "protein_name": "Caspase-8", "gene_name": "Casp8", "organism": "Mouse", "refseq_name": "caspase-8 isoform 1", "refseq_ac": [ { "id": "NP_001073595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073595", "type": "external" } ], "gene_names_uniprotkb": "Casp8", "gene_names_refseq": "CASP-8; Casp8; FLICE; MACH; Mch5", "protein_names_uniprotkb": "Caspase-8; 3.4.22.61; CASP-8", "protein_names_refseq": "Fas-linked ICE-like protease; caspase-8 isoform 1", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); traumatic brain injury (Disease Ontology:DOID:0081292); autoimmune lymphoproliferative syndrome type 2B (Disease Ontology:DOID:0110116); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); autoimmune disease (Disease Ontology:DOID:417); esophagus adenocarcinoma (Disease Ontology:DOID:4914); retinal detachment (Disease Ontology:DOID:5327); kidney disease (Disease Ontology:DOID:557); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12370); (R-MMU-111465); (R-MMU-140534); (R-MMU-168638); (R-MMU-2562578); (R-MMU-264870); (R-MMU-3371378); (R-MMU-5218900); (R-MMU-5357905); (R-MMU-5660668); (R-MMU-5675482); (R-MMU-69416); (R-MMU-75108); (R-MMU-75153); (R-MMU-75157); (R-MMU-75158); (R-MMU-9758274)", "pathway_count": 17, "publication_count": 29, "publication_id_list": "12065591;15383280;17242355;17245429;18455983;19131326;21183079;21750661;23806337;24813849;24813850;26495903;28135057;28528544;29440439;30361383;30381458;31219806;31511692;31519887;31748744;32971525;33397971;34471287;9654089;9727491;9727492;9729047;9837723", "class_list": "", "function": "Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:12065591, PubMed:18455983, PubMed:30361383, PubMed:30381458, PubMed:31511692, PubMed:31748744, PubMed:33397971, PubMed:9727491, PubMed:9727492). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:24813849, PubMed:24813850, PubMed:9654089, PubMed:9837723). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (By similarity). Binding to the adapter molecule FADD recruits it to either receptor FAS/CD95 or TNFRSF1A (PubMed:29440439). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (By similarity). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (By similarity). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (By similarity). Also cleaves and activates BID, thereby promoting cytochrome C release from mitochrondria (PubMed:9727491, PubMed:9727492). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-325', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31511692). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:30361383, PubMed:30381458). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (PubMed:30361383, PubMed:30381458). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (PubMed:32971525). May participate in the Granzyme B (GZMB) cell death pathways (By similarity). Cleaves PARP1 and PARP2 (PubMed:12065591)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35669", "ec_number_list": [ { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.64", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:2001233 regulation of apoptotic signaling pathway;GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0007507 heart development;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "O89110-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08857-1", "uniprot_id": [ { "id": "CD36_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08857", "type": "external" } ], "mass": 52698.0, "length": 472, "protein_name": "Platelet glycoprotein 4", "gene_name": "Cd36", "organism": "Mouse", "refseq_name": "platelet glycoprotein 4", "refseq_ac": [ { "id": "NP_001153027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153027", "type": "external" } ], "gene_names_uniprotkb": "Cd36", "gene_names_refseq": "Cd36; FAT; GPIV; Scarb3", "protein_names_uniprotkb": "Platelet glycoprotein 4; GPIIIB; GPIV; Glycoprotein IIIb; PAS IV; PAS-4; Platelet glycoprotein IV", "protein_names_refseq": "CD36 antigen; GPIIIB; PAS IV; PAS-4; fatty acid translocase; glycoprotein IIIb; platelet glycoprotein 4; platelet glycoprotein IV", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); atrial fibrillation (Disease Ontology:DOID:0060224); myeloid neoplasm (Disease Ontology:DOID:0070004); platelet-type bleeding disorder 10 (Disease Ontology:DOID:0111046); dermatomyositis (Disease Ontology:DOID:10223); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); malaria (Disease Ontology:DOID:12365); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); atherosclerosis (Disease Ontology:DOID:1936); blood platelet disease (Disease Ontology:DOID:2218); essential thrombocythemia (Disease Ontology:DOID:2224); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); nephrosis (Disease Ontology:DOID:2527); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); inclusion body myositis (Disease Ontology:DOID:3429); pulmonary fibrosis (Disease Ontology:DOID:3770); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); polycythemia vera (Disease Ontology:DOID:8997); pemphigus (Disease Ontology:DOID:9182); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12491); (R-MMU-114608); (R-MMU-1236973); (R-MMU-3000471); (R-MMU-434313); (R-MMU-5686938); (R-MMU-6798695)", "pathway_count": 7, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;15690042;15748999;16020694;16276419;17507371;18162488;18332148;18353783;18753675;19362712;19471024;19847289;19864601;20037584;21610069;21750661;21901153;23395392;23557700;23812099;25835637;26495903;26740625;27145700;27802388;28011936;30605677;30899004;32958780;34428180;35984892;36288343;37507081;39927985;7685021", "class_list": "", "function": "(Microbial infection) Acts as an accessory receptor for M.tuberculosis lipoprotein LprA, in conjunction with coreceptors TLR2 and TLR1; the lipoprotein acts as an agonist to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling (PubMed:19864601, PubMed:23395392). Mediates uptake of E.coli and S.aureus but has no effect on uptake of M.fortuitum (PubMed:16020694)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Coexpression of the Olfr287 in olfactory sensory neurons with CD36 suggests that only a specific set of olfactory receptors may be coexpressed with CD36 in these neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long- and very long-chain fatty acids and bacterial diacylated lipopeptides (PubMed:18332148, PubMed:7685021). They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable) (PubMed:19847289, PubMed:20037584, PubMed:23395392). Binds long- and very long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (PubMed:18332148, PubMed:30605677). Mechanistically, palmitoylated CD36 captures fatty acids on the cell surface, the binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36, a step needed to initiate the endocytic process and delivery of fatty acids into the cell (PubMed:32958780). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:17507371, PubMed:18753675, PubMed:21610069). Involved in oral fat perception and preferences (PubMed:16276419). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity) (PubMed:16276419). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (PubMed:18162488). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity) (PubMed:23557700). Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (PubMed:15748999). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting together with THBS1 (PubMed:25835637). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (PubMed:20037584, PubMed:23812099). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:15690042, PubMed:19847289)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 34, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0070538 oleic acid binding;GO:0005044 scavenger receptor activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0001540 amyloid-beta binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:1990379 lipid transport across blood-brain barrier;GO:0098900 regulation of action potential;GO:0071221 cellular response to bacterial lipopeptide;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001676 long-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q08857-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30658-1", "uniprot_id": [ { "id": "CBX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P30658", "type": "external" } ], "mass": 54918.0, "length": 519, "protein_name": "Chromobox protein homolog 2", "gene_name": "Cbx2", "organism": "Mouse", "refseq_name": "chromobox protein homolog 2", "refseq_ac": [ { "id": "NP_031649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031649", "type": "external" } ], "gene_names_uniprotkb": "Cbx2; M33", "gene_names_refseq": "Cbx2; M33; MOD2; pc", "protein_names_uniprotkb": "Chromobox protein homolog 2; M33; Modifier 3 protein", "protein_names_refseq": "M33 polycomb-like protein; chromobox homolog 2; chromobox protein homolog 2; modifier 3 protein", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); 46,XY sex reversal 5 (Disease Ontology:DOID:0111776); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12416); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "1352241;16537902;20493168;22226355;24129315;28528544;30084848;37422020;9312051", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (PubMed:16537902). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355). Involved in sexual development, acting as activator of NR5A1 expression (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice., [RefSeq, PubMed]; This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ABG2;O35731;Q8CIA0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000791 euchromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045137 development of primary sexual characteristics", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PB51-1", "uniprot_id": [ { "id": "CC117_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PB51", "type": "external" } ], "mass": 30427.0, "length": 277, "protein_name": "Coiled-coil domain-containing protein 117", "gene_name": "Ccdc117", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 117", "refseq_ac": [ { "id": "NP_598794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598794", "type": "external" } ], "gene_names_uniprotkb": "Ccdc117", "gene_names_refseq": "1110004K02Rik; 1700026O03Rik; Ccdc117", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 117", "protein_names_refseq": "coiled-coil domain-containing protein 117", "tax_id": 10090, "disease": "", "pathway": " (mmu:104479)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24129315;25428506;30742009;31219806;34428180", "class_list": "", "function": "Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K217;Q99LL1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0072686 mitotic spindle", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PB51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6Y1-1", "uniprot_id": [ { "id": "CCDC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6Y1", "type": "external" } ], "mass": 31093.0, "length": 273, "protein_name": "Coiled-coil domain-containing protein 3", "gene_name": "Ccdc3", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_083080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083080", "type": "external" } ], "gene_names_uniprotkb": "Ccdc3", "gene_names_refseq": "2310045O21Rik; Ccdc3", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 3; Fat/vessel-derived secretory protein; Favine", "protein_names_refseq": "coiled-coil domain-containing protein 3 precursor; coiled-coil domain-containing protein 3; fat/vessel-derived secretory protein; favine", "tax_id": 10090, "disease": "", "pathway": " (mmu:74186)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20043878;25605713;28827783", "class_list": "", "function": "Altogether, these results demonstrate that CCDC3 modulates liver lipid metabolism by inhibiting liver de novo lipogenesis as a downstream player of the p63 network. Publication Status: Online-Only, [RefSeq, PubMed]; Deficiency of Favine attenuated differentiation of primary adipocytes. Taken together, these data demonstrate that Favine has adipogenic and lipogenic effects on adipocytes, [RefSeq, PubMed]; Negatively regulates TNF-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713)., [UniProtKB, UniProtKB, PubMed]; These results indicate that CCDC3 is a protein secreted by adipocytes and endothelial cells, and that its level is regulated both hormonally and nutritionally., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007165 signal transduction;GO:0008203 cholesterol metabolic process;GO:0010629 negative regulation of gene expression;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D6Y1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJV3-1", "uniprot_id": [ { "id": "CCGL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJV3", "type": "external" } ], "mass": 23230.0, "length": 211, "protein_name": "Voltage-dependent calcium channel gamma-like subunit", "gene_name": "Tmem37", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-like subunit", "refseq_ac": [ { "id": "NP_062305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062305", "type": "external" } ], "gene_names_uniprotkb": "Tmem37; Cacng5; Pr1; Pr", "gene_names_refseq": "Pr1; Pr; Tmem37", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-like subunit; Neuronal voltage-gated calcium channel gamma-like subunit; Transmembrane protein 37", "protein_names_refseq": "neuronal voltage-gated calcium channel gamma-like subunit; protein distantly related to to the gamma subunit family; voltage-dependent calcium channel gamma subunit-like protein; voltage-dependent calcium channel gamma-like subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:170706)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10734232", "class_list": "", "function": "Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Modulates calcium current when coexpressed with CACNA1G., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543K0", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0034702 monoatomic ion channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLQ0-1", "uniprot_id": [ { "id": "CD2AP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLQ0", "type": "external" } ], "mass": 70450.0, "length": 637, "protein_name": "CD2-associated protein", "gene_name": "Cd2ap", "organism": "Mouse", "refseq_name": "CD2-associated protein isoform 1", "refseq_ac": [ { "id": "NP_033977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033977", "type": "external" } ], "gene_names_uniprotkb": "Cd2ap; Mets1", "gene_names_refseq": "Cd2ap; METS-1; Mets1", "protein_names_uniprotkb": "CD2-associated protein; METS-1; Mesenchyme-to-epithelium transition protein with SH3 domains 1", "protein_names_refseq": "CD2-associated protein isoform 1; SH3 domain-containing adapter protein; SH3 domain-containing adaptor protein METS-1; mesenchyme to epithelium transition protein, SH3 domains; mesenchyme-to-epithelium transition protein with SH3 domains 1", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis 3 (Disease Ontology:DOID:0112245); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); tauopathy (Disease Ontology:DOID:680); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:12488)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10514378;10913159;11733379;11733557;12217865;14736876;17537921;17922258;18753381;19144319;21183079;21750661;30779550;34428180;37453647;9741631", "class_list": "", "function": "CD2AP is expressed in glomerular podocytes, and may play a role in a specialized adhesion complex known as the slit diaphragm., [RefSeq, PubMed]; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (PubMed:9741631). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus (PubMed:10514378). Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QL86;O88903;Q8K4Z1;Q8VCI9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0001889 liver development;GO:0006468 protein phosphorylation;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JLQ0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70677-1", "uniprot_id": [ { "id": "CASP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70677", "type": "external" } ], "mass": 31475.0, "length": 277, "protein_name": "Caspase-3", "gene_name": "Casp3", "organism": "Mouse", "refseq_name": "caspase-3", "refseq_ac": [ { "id": "NP_001271338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271338", "type": "external" } ], "gene_names_uniprotkb": "Casp3; Cpp32", "gene_names_refseq": "A830040C14Rik; AC-3; CASP-3; CC3; CPP-32; CPP32; Casp3; Caspase-3; Lice; SCA-1; Yama; mldy", "protein_names_uniprotkb": "Caspase-3; 3.4.22.56; Apopain; CASP-3; CPP-32; Cysteine protease CPP32; LICE; Protein Yama; SCA-1; SREBP cleavage activity 1", "protein_names_refseq": "SREBP cleavage activity 1; apopain; caspase 3, apoptosis related cysteine protease; caspase-3; cysteine protease CPP32; protein Yama", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); brain glioma (Disease Ontology:DOID:0060108); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); traumatic brain injury (Disease Ontology:DOID:0081292); endometritis (Disease Ontology:DOID:1002); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); cryptorchidism (Disease Ontology:DOID:11383); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); spermatic cord torsion (Disease Ontology:DOID:11996); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); intestinal disease (Disease Ontology:DOID:5295); kidney disease (Disease Ontology:DOID:557); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12367); (R-MMU-111459); (R-MMU-111465); (R-MMU-111469); (R-MMU-140342); (R-MMU-2028269); (R-MMU-205025); (R-MMU-264870); (R-MMU-351906); (R-MMU-418889); (R-MMU-449836); (R-MMU-5620971); (R-MMU-9960519); (R-MMU-9960525)", "pathway_count": 14, "publication_count": 22, "publication_id_list": "11374883;12124386;15345747;15599395;16469926;17242355;20510932;21116635;21183079;21515572;21750661;23806337;24478350;25231987;28528544;30084848;30878284;33725486;8761296;8934524;9038361;9070890", "class_list": "", "function": "A point mutation in Casp3 alters the catalytic cysteine residue and causes sensorineural hearing loss., [RefSeq, PubMed]; Caspase-3 is crucial for the differentiation of bone marrow stromal stem cells by influencing TGF-beta/Smad2 pathway and cell cycle progression, [RefSeq, PubMed]; Cochlear neuron function, [RefSeq, PubMed]; Hippocampal slices from caspase-3 knockout mice lose specifically their ability to undergo NMDA receptor-dependent long-term depression; these findings reveal a critical role of the mitochondrial pathway of caspase activation in synaptic depression., [RefSeq, PubMed]; Mutation in the planar cell polarity gene, Scrib, and a mutation in caspase-3 gene have the most profound effect in controlling neural development., [RefSeq, PubMed]; Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:16469926, PubMed:8934524). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:16469926, PubMed:8934524). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively). Cleaves and inactivates interleukin-18 (IL18) (By similarity). Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Also involved in axon pruning during brain development (PubMed:24478350). Cleaves DSG2 in response to apoptosis resulting in a loss of full length DSG2 at desmosome cell junctions and subsequent loss of cell-cell adhesion (By similarity). Also cleaves JUP in response to apoptosis (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:12124386). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 57, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08668;Q8CHV5;Q9QWI4", "ec_number_list": [ { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.22.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.64", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.60", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0008047 enzyme activator activity;GO:0044877 protein-containing complex binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006508 proteolysis;GO:0007507 heart development;GO:0007611 learning or memory;GO:0016485 protein processing;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P70677-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBY5-1", "uniprot_id": [ { "id": "CBX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBY5", "type": "external" } ], "mass": 44460.0, "length": 414, "protein_name": "Chromobox protein homolog 6", "gene_name": "Cbx6", "organism": "Mouse", "refseq_name": "chromobox protein homolog 6", "refseq_ac": [ { "id": "NP_083039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083039", "type": "external" } ], "gene_names_uniprotkb": "Cbx6", "gene_names_refseq": "Cbx6", "protein_names_uniprotkb": "Chromobox protein homolog 6", "protein_names_refseq": "chromobox homolog 6; chromobox protein homolog 6", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:494448); (R-MMU-8939243); (R-MMU-8943724)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16537902;18927235;21750661;22226355;34428180", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in an H3K27me3-independent fashion (PubMed:16537902, PubMed:22226355). May have a PRC1-independent function in embryonic stem cells (PubMed:22226355)., [UniProtKB, PubMed, UniProtKB, PubMed]; Different CBX proteins are recruited to distinct chromatin regions through nonconserved interactions. Metaphase spreads revealed reciprocal patterns of chromosome association by CBX2 and CBX6, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZH5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DBY5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VT4-1", "uniprot_id": [ { "id": "CBR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VT4", "type": "external" } ], "mass": 25415.0, "length": 236, "protein_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "gene_name": "Cbr4", "organism": "Mouse", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "refseq_ac": [ { "id": "NP_663570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663570", "type": "external" } ], "gene_names_uniprotkb": "Cbr4", "gene_names_refseq": "A730083J17Rik; Cbr4", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.100; 1.6.5.10; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; CBR4; Carbonyl reductase family member 4; KAR beta subunit; Quinone reductase CBR4", "protein_names_refseq": "3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; KAR beta subunit; carbonyl reductase family member 4; quinone reductase CBR4", "tax_id": 10090, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:234309); (R-MMU-75105)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "20484733;21750661;21952136;23576753;25428506;30084848;30779550;31599954;34428180;37453647;37507081", "class_list": "", "function": "Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBY4;Q8BXV1", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.2", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" } ], "go_molecular_function": "GO:0048038 quinone binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006633 fatty acid biosynthetic process;GO:0051290 protein heterotetramerization;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91VT4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66L44-1", "uniprot_id": [ { "id": "CBARP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66L44", "type": "external" } ], "mass": 74131.0, "length": 698, "protein_name": "Voltage-dependent calcium channel beta subunit-associated regulatory protein", "gene_name": "Cbarp", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 1", "refseq_ac": [ { "id": "NP_001182197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182197", "type": "external" } ], "gene_names_uniprotkb": "Cbarp; 1; Barp; Dos", "gene_names_refseq": "9630008F14; Cbarp; Dos; R29144/1", "protein_names_uniprotkb": "Voltage-dependent calcium channel beta subunit-associated regulatory protein; Downstream of Stk11 protein", "protein_names_refseq": "downstream of Stk11 protein; protein Dos; voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 1; voltage-dependent calcium channel beta subunit-associated regulatory protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503659)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10400995;17114649;21183079;21750661;24751537;25428506", "class_list": "", "function": "Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QP85;Q497H6;Q8CBL1;Q9QZY3", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030426 growth cone;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0045955 negative regulation of calcium ion-dependent exocytosis;GO:1903170 negative regulation of calcium ion transmembrane transport;GO:1901386 negative regulation of voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q66L44-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10605-1", "uniprot_id": [ { "id": "CATB_MOUSE", "url": "https://www.uniprot.org/uniprot/P10605", "type": "external" } ], "mass": 37280.0, "length": 339, "protein_name": "Cathepsin B", "gene_name": "Ctsb", "organism": "Mouse", "refseq_name": "cathepsin B preproprotein", "refseq_ac": [ { "id": "NP_031824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031824", "type": "external" } ], "gene_names_uniprotkb": "Ctsb", "gene_names_refseq": "CB; Ctsb", "protein_names_uniprotkb": "Cathepsin B; 3.4.22.1; Cathepsin B1", "protein_names_refseq": "cathepsin B preproprotein; cathepsin B1", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); polycystic kidney disease (Disease Ontology:DOID:0080322); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); otitis media (Disease Ontology:DOID:10754); intracranial aneurysm (Disease Ontology:DOID:10941); urinary bladder cancer (Disease Ontology:DOID:11054); Guillain-Barre syndrome (Disease Ontology:DOID:12842); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); brain infarction (Disease Ontology:DOID:3454); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); fascioliasis (Disease Ontology:DOID:885); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:13030); (R-MMU-1442490); (R-MMU-1679131); (R-MMU-2022090); (R-MMU-2132295); (R-MMU-6798695); (R-MMU-9766229); (R-MMU-9958810)", "pathway_count": 8, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;12542794;12648094;12782676;1746902;1889751;2012677;21540332;2226854;23806337;25428506;26192747;26495903;26740625;29125738;29562282;30059200;30084848;30899004;31219806;31616917;32152506;34428180;3463996;36084651;36113477;36288343;37453647;37507081;37828378;39927985;40885482;40997131;41391522", "class_list": "", "function": "Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). Has also been implicated in tumor invasion and metastasis (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 23, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDW7", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0005518 collagen binding;GO:0044877 protein-containing complex binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030855 epithelial cell differentiation;GO:0051402 neuron apoptotic process;GO:0046718 symbiont entry into host cell;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P10605-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VEJ0-1", "uniprot_id": [ { "id": "CEP76_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VEJ0", "type": "external" } ], "mass": 74303.0, "length": 659, "protein_name": "Centrosomal protein of 76 kDa", "gene_name": "Cep76", "organism": "Mouse", "refseq_name": "centrosomal protein of 76 kDa isoform 1", "refseq_ac": [ { "id": "NP_001074542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074542", "type": "external" } ], "gene_names_uniprotkb": "Cep76", "gene_names_refseq": "6230425F05Rik; 9630013E05; Cep76", "protein_names_uniprotkb": "Centrosomal protein of 76 kDa; Cep76", "protein_names_refseq": "centrosomal protein of 76 kDa isoform 1; centrosomal protein of 76 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:225659); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "21183079;34428180", "class_list": "", "function": "Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046599 regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VEJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHB8-1", "uniprot_id": [ { "id": "CC177_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHB8", "type": "external" } ], "mass": 79857.0, "length": 706, "protein_name": "Coiled-coil domain-containing protein 177", "gene_name": "Ccdc177", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 177", "refseq_ac": [ { "id": "NP_001008423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008423", "type": "external" } ], "gene_names_uniprotkb": "Ccdc177; Gm1568", "gene_names_refseq": "Ccdc177; Gm1568", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 177", "protein_names_refseq": "coiled-coil domain-containing protein 177", "tax_id": 10090, "disease": "", "pathway": " (mmu:380768)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16452087;21183079;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXJ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UHB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64433-1", "uniprot_id": [ { "id": "CH10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64433", "type": "external" } ], "mass": 10963.0, "length": 102, "protein_name": "10 kDa heat shock protein, mitochondrial", "gene_name": "Hspe1", "organism": "Mouse", "refseq_name": "10 kDa heat shock protein, mitochondrial", "refseq_ac": [ { "id": "NP_032329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032329", "type": "external" } ], "gene_names_uniprotkb": "Hspe1", "gene_names_refseq": "10kDa; Hsp10; Hspe1; mt-cpn10", "protein_names_uniprotkb": "10 kDa heat shock protein, mitochondrial; 10 kDa chaperonin; CPN10; Chaperonin 10; Hsp10", "protein_names_refseq": "10 kDa chaperonin; 10 kDa heat shock protein, mitochondrial; CPN10; chaperonin 10; heat shock 10 kDa protein 1 (chaperonin 10); mitochondrial chaperonin 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:15528); (R-MMU-9013408)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11210183;21183079;23576753;23806337;25505263;26740625;33649389;34428180;35820727;36288343;37453647;37507081;38011257;7929423", "class_list": "", "function": "Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB]; Heat shock protein 10 is a Sirtuin 3 substrate, [RefSeq, PubMed]; Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64433-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQT0-1", "uniprot_id": [ { "id": "CC14A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQT0", "type": "external" } ], "mass": 67634.0, "length": 603, "protein_name": "Dual specificity protein phosphatase CDC14A", "gene_name": "Cdc14a", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase CDC14A isoform 1", "refseq_ac": [ { "id": "NP_001074287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074287", "type": "external" } ], "gene_names_uniprotkb": "Cdc14a", "gene_names_refseq": "A830059A17Rik; CDC14A2; CDC14a1; Cdc14a; Cdc14", "protein_names_uniprotkb": "Dual specificity protein phosphatase CDC14A; 3.1.3.16; 3.1.3.48; CDC14 cell division cycle 14 homolog A", "protein_names_refseq": "CDC14 cell division cycle 14 homolog A; dual specificity protein phosphatase CDC14A isoform 1; dual specificity protein phosphatase CDC14A", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 32 (Disease Ontology:DOID:0110491)", "pathway": " (mmu:229776); (R-MMU-176407); (R-MMU-5687128)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19270517;21750661;26283732;27259055;29293958;32679235;35820727;36326833", "class_list": "", "function": "CDC14A activity is necessary for hearing and male fertility., [RefSeq, PubMed]; CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast., [RefSeq, PubMed]; Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low., [RefSeq, PubMed]; Cdc14a has a role in spermatogenesis, sperm maturation and male fertility., [RefSeq, PubMed]; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). Required for normal hearing (PubMed:29293958)., [UniProtKB, UniProtKB, PubMed]; Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ66", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0051301 cell division;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0000226 microtubule cytoskeleton organization;GO:0007096 regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6GQT0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDK2-1", "uniprot_id": [ { "id": "CBPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDK2", "type": "external" } ], "mass": 99216.0, "length": 862, "protein_name": "Cytosolic carboxypeptidase 2", "gene_name": "Agbl2", "organism": "Mouse", "refseq_name": "cytosolic carboxypeptidase 2 isoform 1", "refseq_ac": [ { "id": "NP_848870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848870", "type": "external" } ], "gene_names_uniprotkb": "Agbl2; Ccp2", "gene_names_refseq": "4930524K04; A430081C19Rik; Agbl2; CCP2", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 2; 3.4.17.-; ATP/GTP-binding protein-like 2; Protein deglutamylase CCP2", "protein_names_refseq": "carboxypeptidase 2, cytosolic; cytosolic carboxypeptidase 2 isoform 1; cytosolic carboxypeptidase 2; protein deglutamylase CCP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:271813)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17244818;21750661;25103237;30016717", "class_list": "", "function": "CCP2 and CCP3 are deglutamylases and are highly regulated proteins confined to ciliated tissues., [RefSeq, PubMed]; Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:25103237). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:25103237). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:25103237)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AH35;Q09M08;Q09M09;Q09M10;Q09M11;Q09M12;Q8C529;Q8C9X4;Q8CDE6;Q8CDF6;Q8CDQ1", "ec_number_list": [ { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006508 proteolysis;GO:0035610 protein side chain deglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CDK2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3W3-1", "uniprot_id": [ { "id": "CASC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3W3", "type": "external" } ], "mass": 75770.0, "length": 698, "protein_name": "Protein CASC3", "gene_name": "Casc3", "organism": "Mouse", "refseq_name": "protein CASC3", "refseq_ac": [ { "id": "NP_619601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619601", "type": "external" } ], "gene_names_uniprotkb": "Casc3; Mln51", "gene_names_refseq": "Btz; Casc3; Mln51", "protein_names_uniprotkb": "Protein CASC3; Btz; Cancer susceptibility candidate gene 3 protein homolog; MLN 51 homolog; Metastatic lymph node gene 51 protein homolog; Protein barentsz; mBtz", "protein_names_refseq": "Barentsz; MLN 51 homolog; cancer susceptibility candidate 3; cancer susceptibility candidate gene 3 protein homolog; mBtz; metastatic lymph node 51; metastatic lymph node gene 51 protein homolog; protein CASC3; protein barentsz", "tax_id": 10090, "disease": "", "pathway": " (mmu:192160); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-975957)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "12080473;12843282;17242355;19131326;21183079;31219806;32782141;34428180;36852467", "class_list": "", "function": "Data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic ribonucleoprotein particles in hippocampal neurons, [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KFP7;Q3UT99;Q8K219;Q99NF0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0008298 intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K3W3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHF2-1", "uniprot_id": [ { "id": "CDHR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHF2", "type": "external" } ], "mass": 88208.0, "length": 831, "protein_name": "Cadherin-related family member 5", "gene_name": "Cdhr5", "organism": "Mouse", "refseq_name": "cadherin-related family member 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001107794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107794", "type": "external" } ], "gene_names_uniprotkb": "Cdhr5; Mucdhl; Mupcdh", "gene_names_refseq": "1810074H01Rik; Cdhr5; Mucdhl; Mupcdh", "protein_names_uniprotkb": "Cadherin-related family member 5; Mu-protocadherin", "protein_names_refseq": "cadherin-related family member 5 isoform 1 precursor; mu-protocadherin; mucin and cadherin-like protein; mucin-like protocadherin", "tax_id": 10090, "disease": "", "pathway": " (mmu:72040)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10801787;12589428;17242355;21183079;21750661;22299025;31361958;31599954", "class_list": "", "function": "Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation., [UniProtKB, UniProtKB]; MUCDHL genes are biallelically expressed in multiple fetal and adult tissues both in humans and in mice, [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 11, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEJ3;Q9D8I9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045202 synapse;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:1904970 brush border assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VHF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88552-1", "uniprot_id": [ { "id": "CLD2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88552", "type": "external" } ], "mass": 24484.0, "length": 230, "protein_name": "Claudin-2", "gene_name": "Cldn2", "organism": "Mouse", "refseq_name": "claudin-2", "refseq_ac": [ { "id": "NP_057884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057884", "type": "external" } ], "gene_names_uniprotkb": "Cldn2", "gene_names_refseq": "Cldn2", "protein_names_uniprotkb": "Claudin-2", "protein_names_refseq": "claudin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12738)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10508613;10562289;10601346;11934881;12432083;19114638;21183079;21750661;23089202;23677799;25068494;25428506;27214555;28618266;31599954;32149733;37815870;38412124;9647647", "class_list": "", "function": "Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing. Publication Status: Online-Only, [RefSeq, PubMed]; Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis., [RefSeq, PubMed]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:10508613, PubMed:12432083, PubMed:19114638, PubMed:23677799). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (PubMed:23089202, PubMed:28618266). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (PubMed:27214555, PubMed:32149733). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (PubMed:25068494)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:1904729 regulation of intestinal lipid absorption;GO:0098609 cell-cell adhesion;GO:0002227 innate immune response in mucosa;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0120188 regulation of bile acid secretion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O88552-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27790-1", "uniprot_id": [ { "id": "CENPB_MOUSE", "url": "https://www.uniprot.org/uniprot/P27790", "type": "external" } ], "mass": 65381.0, "length": 599, "protein_name": "Major centromere autoantigen B", "gene_name": "Cenpb", "organism": "Mouse", "refseq_name": "major centromere autoantigen B", "refseq_ac": [ { "id": "NP_031708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031708", "type": "external" } ], "gene_names_uniprotkb": "Cenpb; Cenp-b", "gene_names_refseq": "CENP-B; Cenpb", "protein_names_uniprotkb": "Major centromere autoantigen B; CENP-B; Centromere protein B", "protein_names_refseq": "centromere autoantigen B; major centromere autoantigen B", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); inner ear disease (Disease Ontology:DOID:2952)", "pathway": " (mmu:12616)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12011073;1893793;34433012;34547289", "class_list": "", "function": "CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA., [RefSeq, PubMed]; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes., [UniProtKB, UniProtKB]; Parallel pathways for recruiting effector proteins determine centromere drive and suppression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSG8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000775 chromosome, centromeric region;GO:0005694 chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27790-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QRL3-1", "uniprot_id": [ { "id": "CC88B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4QRL3", "type": "external" } ], "mass": 166608.0, "length": 1481, "protein_name": "Coiled-coil domain-containing protein 88B", "gene_name": "Ccdc88b", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 88B", "refseq_ac": [ { "id": "NP_001074760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074760", "type": "external" } ], "gene_names_uniprotkb": "Ccdc88b; Ccdc88", "gene_names_refseq": "2610041P08Rik; Ccdc88b; Ccdc88", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 88B; Gipie; HkRP3; Hook-related protein 3", "protein_names_refseq": "coiled-coil domain containing 88; coiled-coil domain-containing protein 88B; gipie; hkRP3; hook-related protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:78317)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19144319;21183079;21289099;21750661;25403443;29030607;32480428;32782141;38200184", "class_list": "", "function": "A critical function of CCDC88B in colonic inflammation Publication Status: Online-Only, [RefSeq, PubMed]; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei (PubMed:25403443). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (By similarity). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099)., [UniProtKB, UniProtKB, PubMed, PubMed]; CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. Publication Status: Online-Only, [RefSeq, PubMed]; CCDC88B is required for mobility and inflammatory functions of dendritic cells., [RefSeq, PubMed]; These results identify CCDC88B as a novel and important regulator of T cell function., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RX63", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0001819 positive regulation of cytokine production;GO:0042102 positive regulation of T cell proliferation;GO:0050870 positive regulation of T cell activation;GO:0042832 defense response to protozoan;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q4QRL3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDY0-1", "uniprot_id": [ { "id": "CC85B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDY0", "type": "external" } ], "mass": 22133.0, "length": 202, "protein_name": "Coiled-coil domain-containing protein 85B", "gene_name": "Ccdc85b", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 85B isoform 1", "refseq_ac": [ { "id": "NP_941018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941018", "type": "external" } ], "gene_names_uniprotkb": "Ccdc85b; Dipa", "gene_names_refseq": "Ccdc85b", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 85B; Delta-interacting protein A homolog; Hepatitis delta antigen-interacting protein A homolog", "protein_names_refseq": "coiled-coil domain-containing protein 85B isoform 1; coiled-coil domain-containing protein 85B; delta-interacting protein A homolog; hepatitis delta antigen-interacting protein A homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:240514)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15644333;21750661;22666460;27404227", "class_list": "", "function": "Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (PubMed:15644333, PubMed:22666460). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070097 delta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005912 adherens junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PDY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z309-1", "uniprot_id": [ { "id": "CIB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z309", "type": "external" } ], "mass": 21704.0, "length": 187, "protein_name": "Calcium and integrin-binding family member 2", "gene_name": "Cib2", "organism": "Mouse", "refseq_name": "calcium and integrin-binding family member 2", "refseq_ac": [ { "id": "NP_062660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062660", "type": "external" } ], "gene_names_uniprotkb": "Cib2; Kip2", "gene_names_refseq": "2810434I23Rik; Cib2; KIP 2; KIP2", "protein_names_uniprotkb": "Calcium and integrin-binding family member 2; KIP 2; Kinase-interacting protein 2", "protein_names_refseq": "calcium and integrin-binding family member 2; calcium binding protein Kip2; kinase-interacting protein 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 48 (Disease Ontology:DOID:0110505); Usher syndrome type 1 (Disease Ontology:DOID:0110826)", "pathway": " (mmu:56506)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18611855;18989529;23023331;28663585;29084757;29255404;34089643;34428180;37128899;38228630;9931475", "class_list": "", "function": "CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling., [RefSeq, PubMed]; Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (PubMed:23023331, PubMed:28663585, PubMed:29084757, PubMed:29255404, PubMed:34089643). Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (PubMed:34089643). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (PubMed:28663585, PubMed:29084757, PubMed:29255404). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (PubMed:34089643). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (PubMed:28663585, PubMed:29084757, PubMed:29255404). Critical for proper photoreceptor cell maintenance and function (PubMed:23023331). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331). Seems to be dispensable for vestibular functions (PubMed:29084757)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0001917 photoreceptor inner segment;GO:0071944 cell periphery", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045494 photoreceptor cell maintenance;GO:0055074 calcium ion homeostasis;GO:0071318 cellular response to ATP", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z309-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40201-1", "uniprot_id": [ { "id": "CHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P40201", "type": "external" } ], "mass": 196385.0, "length": 1711, "protein_name": "ATP-dependent chromatin remodeler CHD1", "gene_name": "Chd1", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD1", "refseq_ac": [ { "id": "NP_031716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031716", "type": "external" } ], "gene_names_uniprotkb": "Chd1; Chd-1", "gene_names_refseq": "4930525N21Rik; Chd1", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD1; 3.6.4.-; CHD-1; Chromo domain-containing protein 1", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD1; ATP-dependent helicase CHD1; CHD-1; chromo domain-containing protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:12648)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10199952;12890497;19224205;19587682;20173027;21183079;21750661;22872234;30084848;31219806;34381042;34428180;36210013;7739555;8460153", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (By similarity). Required for maintaining open chromatin and pluripotency in embryonic stem cells (PubMed:19587682). Is also associated with histone deacetylase (HDAC) activity (PubMed:12890497)., [UniProtKB, PubMed, UniProtKB, PubMed]; Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BJ0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0043923 host-mediated activation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40201-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88200-1", "uniprot_id": [ { "id": "CLC11_MOUSE", "url": "https://www.uniprot.org/uniprot/O88200", "type": "external" } ], "mass": 36451.0, "length": 328, "protein_name": "C-type lectin domain family 11 member A", "gene_name": "Clec11a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 11 member A precursor", "refseq_ac": [ { "id": "NP_033157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033157", "type": "external" } ], "gene_names_uniprotkb": "Clec11a; Scgf", "gene_names_refseq": "Clec11a; Clecsf3; Scgf", "protein_names_uniprotkb": "C-type lectin domain family 11 member A; Lymphocyte secreted C-type lectin; Osteolectin; Stem cell growth factor", "protein_names_refseq": "C-type lectin domain family 11 member A precursor; lymphocyte secreted C-type lectin; osteolectin; stem cell growth factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:20256)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11418691;11920266;27976999;34140410;34428180;9705843", "class_list": "glycogene", "function": "In situ hybridization of whole mouse fetuses and their tibias demonstrated expression of SCGF mRNA around skeletal tissues, particularly in bone marrow cells, proliferating chondrocytes, the perichondrium and periosteum., [RefSeq, PubMed]; Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone., [UniProtKB, PubMed]; The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin., [RefSeq, PubMed]; This protein mediates eosinophil recruitment in a mouse model of allergic pleurisy via production of the chemoattractant lipid leukotriene B4., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C946;Q9CTF0", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88200-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88696-1", "uniprot_id": [ { "id": "CLPP_MOUSE", "url": "https://www.uniprot.org/uniprot/O88696", "type": "external" } ], "mass": 29800.0, "length": 272, "protein_name": "ATP-dependent Clp protease proteolytic subunit, mitochondrial", "gene_name": "Clpp", "organism": "Mouse", "refseq_name": "ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_059089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059089", "type": "external" } ], "gene_names_uniprotkb": "Clpp", "gene_names_refseq": "Clpp; D17Wsu160e", "protein_names_uniprotkb": "ATP-dependent Clp protease proteolytic subunit, mitochondrial; 3.4.21.92; Caseinolytic mitochondrial matrix peptidase proteolytic subunit; Endopeptidase Clp", "protein_names_refseq": "ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor; ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit; caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog; caseinolytic protease, ATP-dependent, proteolytic subunit homolog; endopeptidase Clp; putative ATP-dependent Clp protease proteolytic subunit, mitochondrial", "tax_id": 10090, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857)", "pathway": " (mmu:53895); (R-MMU-9837999)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10754102;19154341;22710082;23576753;23806337;23851121;36288343;38339144;38397478;38927630", "class_list": "", "function": "CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion., [UniProtKB, UniProtKB]; The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI13", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0009368 endopeptidase Clp complex", "go_biological_process": "GO:0006508 proteolysis;GO:0051603 proteolysis involved in protein catabolic process;GO:0033619 membrane protein proteolysis;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88696-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56857-1", "uniprot_id": [ { "id": "CLD18_MOUSE", "url": "https://www.uniprot.org/uniprot/P56857", "type": "external" } ], "mass": 28122.0, "length": 264, "protein_name": "Claudin-18", "gene_name": "Cldn18", "organism": "Mouse", "refseq_name": "claudin-18 isoform A2.1", "refseq_ac": [ { "id": "NP_001181850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181850", "type": "external" } ], "gene_names_uniprotkb": "Cldn18", "gene_names_refseq": "Cldn18", "protein_names_uniprotkb": "Claudin-18", "protein_names_refseq": "Claudin-18; claudin-18 isoform A2.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56492)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11585919;14698084;19706394;21183079;22079592;22437732;23299504;24588076;24787463;29400695;30084848;34702961;37046312;38749447", "class_list": "", "function": "Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area., [RefSeq, PubMed]; Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer., [RefSeq, PubMed]; FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (PubMed:24588076). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (PubMed:24787463). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (PubMed:29400695). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (PubMed:22437732). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (PubMed:23299504)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection., [UniProtKB, PubMed]; Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification., [UniProtKB, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZY9;Q91ZZ0;Q91ZZ1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0070160 tight junction", "go_biological_process": "GO:0120192 tight junction assembly;GO:0042045 epithelial fluid transport;GO:0045471 response to ethanol;GO:0048286 lung alveolus development;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P56857-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60771-1", "uniprot_id": [ { "id": "CLD11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60771", "type": "external" } ], "mass": 22114.0, "length": 207, "protein_name": "Claudin-11", "gene_name": "Cldn11", "organism": "Mouse", "refseq_name": "claudin-11", "refseq_ac": [ { "id": "NP_032796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032796", "type": "external" } ], "gene_names_uniprotkb": "Cldn11; Osp; Otm", "gene_names_refseq": "Claudin-11; Claudin11; Cldn11; Osp; Otm", "protein_names_uniprotkb": "Claudin-11; Oligodendrocyte transmembrane protein; Oligodendrocyte-specific protein", "protein_names_refseq": "claudin-11; oligodendrocyte transmembrane protein; oligodendrocyte-specific protein", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 22 (Disease Ontology:DOID:0070402)", "pathway": " (mmu:18417)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10225958;11309411;17082656;18801757;21183079;22645316;30734065;33300544;38553809;8797478", "class_list": "", "function": "CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis in Gastric Cancer., [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB, UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545N5;Q9DB65", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0030424 axon", "go_biological_process": "GO:0120192 tight junction assembly;GO:0007155 cell adhesion;GO:0007283 spermatogenesis;GO:0008366 axon ensheathment;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q60771-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0H8-1", "uniprot_id": [ { "id": "CLIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0H8", "type": "external" } ], "mass": 115910.0, "length": 1047, "protein_name": "CAP-Gly domain-containing linker protein 2", "gene_name": "Clip2", "organism": "Mouse", "refseq_name": "CAP-Gly domain-containing linker protein 2 isoform b", "refseq_ac": [ { "id": "NP_001034251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034251", "type": "external" } ], "gene_names_uniprotkb": "Clip2; Cyln2; Kiaa0291", "gene_names_refseq": "B230327O20; CLIP-115; Clip1; Clip2; Cyln2; WSCR4; mKIAA0291; wbscr4", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 2; CLIP-115; Cytoplasmic linker protein 115; Cytoplasmic linker protein 2", "protein_names_refseq": "CAP-Gly domain-containing linker protein 2 isoform b; CAP-Gly domain-containing linker protein 2; cytoplasmic linker protein 1, 115 kDa; cytoplasmic linker protein 2", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:269713)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11290329;16954346;21183079;29562282;34428180;40885482;9427243;9799601", "class_list": "", "function": "Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSI9;Q8CHU1;Q9EP81", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0015630 microtubule cytoskeleton;GO:0005881 cytoplasmic microtubule;GO:0042599 lamellar body", "go_biological_process": "GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z0H8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9F6-1", "uniprot_id": [ { "id": "CTSRD_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9F6", "type": "external" } ], "mass": 91096.0, "length": 805, "protein_name": "Cation channel sperm-associated auxiliary subunit delta", "gene_name": "Catsperd", "organism": "Mouse", "refseq_name": "cation channel sperm-associated auxiliary subunit delta isoform 1 precursor", "refseq_ac": [ { "id": "NP_780559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780559", "type": "external" } ], "gene_names_uniprotkb": "Catsperd; Tmem146", "gene_names_refseq": "4921529N20Rik; 4933402B14Rik; 619718; Catsperd; Gm6095; Tmem146", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit delta; CatSper-delta; CatSperdelta; Transmembrane protein 146", "protein_names_refseq": "catSper-delta; catSperdelta; cation channel sperm-associated auxiliary subunit delta isoform 1 precursor; cation channel sperm-associated protein subunit delta; transmembrane protein 146", "tax_id": 10090, "disease": "", "pathway": " (mmu:106757); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21224844;21750661;34225353;34428180;34998468", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:21224844). Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (PubMed:21224844)., [UniProtKB, PubMed, PubMed]; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E7DZL7;E7DZL8;E9Q710;Q1JPR3;Q1LZJ6;Q8C5U5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9Q9F6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP43-1", "uniprot_id": [ { "id": "CTSRE_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DP43", "type": "external" } ], "mass": 113803.0, "length": 985, "protein_name": "Cation channel sperm-associated auxiliary subunit epsilon", "gene_name": "Catspere1; Catspere", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Catspere1; Catspere; Catspere1; Gm7068", "gene_names_refseq": "", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit epsilon; C1orf101-like protein; CatSper-epsilon; CatSperepsilon", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:631584)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;28226241;34225353;34998468", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:28226241, PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:28226241)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P0DP43-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63154-1", "uniprot_id": [ { "id": "CRNL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63154", "type": "external" } ], "mass": 83416.0, "length": 690, "protein_name": "Crooked neck-like protein 1", "gene_name": "Crnkl1", "organism": "Mouse", "refseq_name": "crooked neck-like protein 1", "refseq_ac": [ { "id": "NP_080096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080096", "type": "external" } ], "gene_names_uniprotkb": "Crnkl1", "gene_names_refseq": "1200013P10Rik; 5730590A01Rik; Crnkl1; crn", "protein_names_uniprotkb": "Crooked neck-like protein 1; Crooked neck homolog", "protein_names_refseq": "Crn, crooked neck-like 1; crooked neck homolog; crooked neck-like protein 1", "tax_id": 10090, "disease": "basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (mmu:66877); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15189447;17242355;30084848;33300544;34428180", "class_list": "", "function": "Involved in pre-mRNA splicing process. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542E8;Q9CQC1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63154-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9K8-1", "uniprot_id": [ { "id": "CSKI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9K8", "type": "external" } ], "mass": 150495.0, "length": 1431, "protein_name": "Caskin-1", "gene_name": "Caskin1", "organism": "Mouse", "refseq_name": "caskin-1 isoform 1", "refseq_ac": [ { "id": "NP_082213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082213", "type": "external" } ], "gene_names_uniprotkb": "Caskin1; Kiaa1306", "gene_names_refseq": "3300002N10Rik; C130061I24; C630036E02Rik; Caskin1; mKIAA1306", "protein_names_uniprotkb": "Caskin-1; CASK-interacting protein 1", "protein_names_refseq": "caskin-1 isoform 1; caskin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268932)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16452087;17114649;18034455;21183079;22645316;30359304;31727973;33300544", "class_list": "", "function": "Caskin1 contributes to a wide spectrum of behavioral phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins. Publication Status: Online-Only, [RefSeq, PubMed]; May link the scaffolding protein CASK to downstream intracellular effectors., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPU2;Q8BWU2;Q8BX99;Q9CXH0", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0007165 signal transduction;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P9K8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T79-3", "uniprot_id": [ { "id": "CSMD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80T79", "type": "external" } ], "mass": 405762.0, "length": 3707, "protein_name": "CUB and sushi domain-containing protein 3", "gene_name": "Csmd3", "organism": "Mouse", "refseq_name": "CUB and sushi domain-containing protein 3", "refseq_ac": [ { "id": "NP_001074860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074860", "type": "external" } ], "gene_names_uniprotkb": "Csmd3; Kiaa1894", "gene_names_refseq": "4930500N14Rik; Csmd3; mKIAA1894", "protein_names_uniprotkb": "CUB and sushi domain-containing protein 3; CUB and sushi multiple domains protein 3", "protein_names_refseq": "CUB and sushi domain-containing protein 3; CUB and sushi multiple domains protein 3", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:239420)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;24523945;25428506;27033969;27802388;30059200;30899004;31219806;33300544;34203471;37037606;37828378", "class_list": "", "function": "CSMD3 Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice., [RefSeq, PubMed]; CSMD3 acts as a co-receptor of an unidentified membrane protein to regulate dendrite development., [RefSeq, PubMed]; Csmd3 has relatively high and selective expression in the brain but as of 2014 has not been well-studied with respect to CNS function or disease associations. It is part of the core brain ignorome. The expression of Csmd3 is tightly linked with Scn3a in mouse hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in dendrite development., [UniProtKB, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 13, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 29, "binding_glycan_count": 0, "secondary_ac_list": "Q3USM6;Q8BVJ0;Q9D588", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q80T79-3", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YR6-1", "uniprot_id": [ { "id": "CTIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YR6", "type": "external" } ], "mass": 100831.0, "length": 893, "protein_name": "DNA endonuclease RBBP8", "gene_name": "Rbbp8", "organism": "Mouse", "refseq_name": "DNA endonuclease RBBP8", "refseq_ac": [ { "id": "NP_001074692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074692", "type": "external" } ], "gene_names_uniprotkb": "Rbbp8; Ctip", "gene_names_refseq": "9930104E21Rik; CtIP; RBBP-8; RIM; Rbbp8; SAE2", "protein_names_uniprotkb": "DNA endonuclease RBBP8; 3.1.-.-; CtBP-interacting protein; CtIP; RBBP-8; RIM; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; SAE2; Sporulation in the absence of SPO11 protein 2 homolog", "protein_names_refseq": "DNA endonuclease RBBP8; ctBP-interacting protein; retinoblastoma-binding protein 8; sporulation in the absence of SPO11 protein 2 homolog", "tax_id": 10090, "disease": "Seckel syndrome 2 (Disease Ontology:DOID:0070013)", "pathway": " (mmu:225182); (R-MMU-5685938); (R-MMU-5685939); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "15831459;16093251;16581787;20829486;21131978;21131982;21183079;21750661;23353824;31219806;32782141;34428180;36852467;40021952", "class_list": "", "function": "CtIP counteracts Rb-mediated G(1) restraint., [RefSeq, PubMed]; CtiP activates its own and cyclin D promoters via the E2F/RB pathway during G1/S progression., [RefSeq, PubMed]; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (By similarity). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (By similarity). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (By similarity). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (By similarity). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (By similarity). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (PubMed:21131978, PubMed:21131982). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003684 damaged DNA binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0035861 site of double-strand break;GO:0070533 BRCA1-C complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80YR6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLQ7-1", "uniprot_id": [ { "id": "CTR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLQ7", "type": "external" } ], "mass": 68350.0, "length": 635, "protein_name": "Cationic amino acid transporter 4", "gene_name": "Slc7a4", "organism": "Mouse", "refseq_name": "cationic amino acid transporter 4 isoform 2", "refseq_ac": [ { "id": "NP_659101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659101", "type": "external" } ], "gene_names_uniprotkb": "Slc7a4", "gene_names_refseq": "Slc7a4", "protein_names_uniprotkb": "Cationic amino acid transporter 4; CAT-4; CAT4; Solute carrier family 7 member 4", "protein_names_refseq": "CAT-4; CAT4; cationic amino acid transporter 4 isoform 2; cationic amino acid transporter 4; solute carrier family 7 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:224022)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17114649;21183079;21750661;34203471;34428180", "class_list": "", "function": "Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0046943 carboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BLQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5K5-1", "uniprot_id": [ { "id": "CX038_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5K5", "type": "external" } ], "mass": 36589.0, "length": 320, "protein_name": "Uncharacterized protein CXorf38 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein CXorf38 homolog", "refseq_ac": [ { "id": "NP_780350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780350", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1810030O07Rik", "protein_names_uniprotkb": "Uncharacterized protein CXorf38 homolog", "protein_names_refseq": "uncharacterized protein CXorf38 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69155)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24129315;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFM9;Q8CF12", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C5K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHY0-1", "uniprot_id": [ { "id": "CSPG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHY0", "type": "external" } ], "mass": 252309.0, "length": 2327, "protein_name": "Chondroitin sulfate proteoglycan 4", "gene_name": "Cspg4", "organism": "Mouse", "refseq_name": "chondroitin sulfate proteoglycan 4 precursor", "refseq_ac": [ { "id": "NP_620570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620570", "type": "external" } ], "gene_names_uniprotkb": "Cspg4; An2; Kiaa4232; Ng2", "gene_names_refseq": "4732461B14Rik; AN2; Cspg4a; Cspg4; NG2", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 4; Chondroitin sulfate proteoglycan NG2; Proteoglycan AN2", "protein_names_refseq": "AN2 proteoglycan; AN2/NG2 proteoglycan; chondroitin sulfate proteoglycan 4 precursor; chondroitin sulfate proteoglycan NG2; nerve/glial antigen 2; proteoglycan AN2", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); brain ischemia (Disease Ontology:DOID:2316); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:121021); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10036240;12458226;15181153;19656770;25428506;25428507;27802388;30084848;30899004;31219806;33300544;34428180", "class_list": "glycogene", "function": "Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 133, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 4, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "G5E892;Q5DTG1;Q8BPI8;Q8CE79", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0019901 protein kinase binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0016322 neuron remodeling;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8VHY0-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLB4-1", "uniprot_id": [ { "id": "CUBN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLB4", "type": "external" } ], "mass": 399097.0, "length": 3623, "protein_name": "Cubilin", "gene_name": "Cubn", "organism": "Mouse", "refseq_name": "cubilin precursor", "refseq_ac": [ { "id": "NP_001074553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074553", "type": "external" } ], "gene_names_uniprotkb": "Cubn; Ifcr", "gene_names_refseq": "Cubn; D2Wsu88e", "protein_names_uniprotkb": "Cubilin; Intrinsic factor-cobalamin receptor", "protein_names_refseq": "cubilin precursor; intrinsic factor-cobalamin receptor", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:65969)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10766831;11278724;11856751;14983511;15342463;15616221;19349973;30084848;31219806;37126375;37828378", "class_list": "", "function": "Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells., [RefSeq, PubMed]", "predicted_glycosites": 33, "predicted_n_glycosites": 32, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 8686, "biomarker_type": "", "glycan_count": 9, "disease_count": 3, "glyco_site_count": 40, "binding_glycan_count": 0, "secondary_ac_list": "B1AX10", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030492 hemoglobin binding;GO:0031419 cobalamin binding", "go_cellular_component": "GO:0030135 coated vesicle;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0042953 lipoprotein transport;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9JLB4-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0D9-1", "uniprot_id": [ { "id": "CX3C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0D9", "type": "external" } ], "mass": 40266.0, "length": 354, "protein_name": "CX3C chemokine receptor 1", "gene_name": "Cx3cr1", "organism": "Mouse", "refseq_name": "CX3C chemokine receptor 1", "refseq_ac": [ { "id": "NP_034117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034117", "type": "external" } ], "gene_names_uniprotkb": "Cx3cr1", "gene_names_refseq": "Cx3cr1; mCX3CR1", "protein_names_uniprotkb": "CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Fractalkine receptor; mCX3CR1", "protein_names_refseq": "C-X3-C CKR-1; CX3C chemokine receptor 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; fractalkine receptor", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); age related macular degeneration 12 (Disease Ontology:DOID:0110024); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); sciatic neuropathy (Disease Ontology:DOID:11446); retinal vasculitis (Disease Ontology:DOID:11563); uveitis (Disease Ontology:DOID:13141); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); prion disease (Disease Ontology:DOID:649); psoriasis (Disease Ontology:DOID:8893); hepatopulmonary syndrome (Disease Ontology:DOID:900); systemic lupus erythematosus (Disease Ontology:DOID:9074); pulmonary embolism (Disease Ontology:DOID:9477); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13051); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10187784;10805752;11544273;12569158;12871640;15653504;16675847;16732273;18322241;18971423;21037587;21183079;21778362;24487234;29326275;33548172;9918795", "class_list": "", "function": "CX3CR1 has a role in atherosclerosis, [RefSeq, PubMed]; Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10187784, PubMed:9918795). CX3CR1-CX3CL1 signaling mediates cell migratory functions (PubMed:11544273, PubMed:12871640, PubMed:16675847, PubMed:18322241). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (PubMed:12569158, PubMed:18971423). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (PubMed:21037587). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (PubMed:12871640). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:18322241). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (PubMed:16732273, PubMed:21778362, PubMed:24487234). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (PubMed:16732273). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (PubMed:21778362). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (PubMed:24487234). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (PubMed:15653504, PubMed:29326275). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (PubMed:15653504). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275, PubMed:33548172). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031737 CX3C chemokine receptor binding;GO:0004930 G protein-coupled receptor activity;GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0097447 dendritic tree;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:0001774 microglial cell activation;GO:0002931 response to ischemia;GO:0006935 chemotaxis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z0D9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z125-1", "uniprot_id": [ { "id": "CR3L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z125", "type": "external" } ], "mass": 56959.0, "length": 519, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 1", "gene_name": "Creb3l1", "organism": "Mouse", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 1", "refseq_ac": [ { "id": "NP_036087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036087", "type": "external" } ], "gene_names_uniprotkb": "Creb3l1; Oasis", "gene_names_refseq": "Creb3l1; Oasis", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 1; OA-N; OASIS; Oasis N-terminal fragment; Old astrocyte specifically-induced substance; cAMP-responsive element-binding protein 3-like protein 1", "protein_names_refseq": "BBF-2 homolog; cAMP-responsive element-binding protein 3-like protein 1; cyclic AMP-responsive element-binding protein 3-like protein 1; old astrocyte specifically induced substance", "tax_id": 10090, "disease": "osteogenesis imperfecta type 16 (Disease Ontology:DOID:0110345)", "pathway": " (mmu:26427)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10350641;12480185;12684764;15665855;19767743;21750661;22705851;33150680;37178686;39384739", "class_list": "", "function": "CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that OASIS protein positively regulates gene transcription in a subset of reactive astrocytes, and may influence the reaction of injured central nervous system tissues [OASIS protein]., [RefSeq, PubMed]; In mice, the OASIS gene may be related to proteoglycan expression and play a role in the differentiation of the odontoblast and cells in inner enamel epithelium., [RefSeq, PubMed]; Our results reveal pivotal roles for OASIS in modulating the unfolded protein response in astrocytes, and the possibility that cell type-specific UPR signalling also exists in other cells, [RefSeq, PubMed]; Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition., [UniProtKB, PubMed]; Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR) (PubMed:19767743, PubMed:37178686). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (PubMed:19767743). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (PubMed:12480185, PubMed:15665855). In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:37178686). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91W70", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z125-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19096-1", "uniprot_id": [ { "id": "FAS_MOUSE", "url": "https://www.uniprot.org/uniprot/P19096", "type": "external" } ], "mass": 272428.0, "length": 2504, "protein_name": "Fatty acid synthase", "gene_name": "Fasn", "organism": "Mouse", "refseq_name": "fatty acid synthase", "refseq_ac": [ { "id": "NP_032014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032014", "type": "external" } ], "gene_names_uniprotkb": "Fasn", "gene_names_refseq": "A630082H08Rik; FAS; Fasn", "protein_names_uniprotkb": "Fatty acid synthase; 2.3.1.85; Type I Fatty Acid Synthase", "protein_names_refseq": "fatty acid synthase; type I Fatty Acid Synthase", "tax_id": 10090, "disease": "muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14104); (R-MMU-199220); (R-MMU-75105)", "pathway_count": 3, "publication_count": 38, "publication_id_list": "10.1101/2023.09.13.557529;11029661;18250455;18299400;20173027;21183079;21750661;21952136;21987372;23806337;24788674;25153642;25428506;25605945;26740625;28011936;29187734;2920037;29328619;30084848;30779550;31219806;31599954;31811668;33300544;33649389;34203471;34428180;35820727;35984892;36210013;37453647;37507081;37828378;39627609;39927985;39950311;9285407", "class_list": "", "function": "Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1ATU8;Q6PB72;Q8C4Z0;Q9EQR0", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "2.7.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.7", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031177 phosphopantetheine binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P19096-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D172-1", "uniprot_id": [ { "id": "GAL3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D172", "type": "external" } ], "mass": 28090.0, "length": 266, "protein_name": "Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial", "gene_name": "Gatd3a; Gatd3", "organism": "Mouse", "refseq_name": "glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_613067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613067", "type": "external" } ], "gene_names_uniprotkb": "Gatd3a; Gatd3; D10Jhu81e; Gatd3a", "gene_names_refseq": "C21orf33; D10Jhu81e; ES1; Gatd3a; Gatd3", "protein_names_uniprotkb": "Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial", "protein_names_refseq": "ES1 protein homolog, mitochondrial; glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial isoform 1 precursor; glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial; glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:28295)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;23576753;23806337;30084848;34428180;36288343;37453647;37507081;39927985", "class_list": "", "function": "Acts as a mitochondrial deglycase involved in the removal of early non-enzymatic glycation adducts from amino acids and nucleotides, thereby restricting the formation of advanced glycation end products (AGEs) within mitochondria. Required to maintain low levels of glycation on mitochondrial ribosomal RNA and proteins, supporting efficient mitochondrial gene expression. Contributes to mitochondrial homeostasis, normal respiratory capacity, and proper mitochondrial network organization. Acts also as a mitochondrial regulator of malate dehydrogenase MDH2 by competitively limiting the association of MDH2 with the mitochondrial deacetylase SIRT3, thereby preserving MDH2 acetylation and enzymatic activity. Through this mechanism, supports efficient conversion of malate to oxaloacetate, sustaining TCA cycle continuity and oxidative phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D172-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH16-1", "uniprot_id": [ { "id": "FBXL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH16", "type": "external" } ], "mass": 46890.0, "length": 423, "protein_name": "F-box/LRR-repeat protein 2", "gene_name": "Fbxl2", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 2", "refseq_ac": [ { "id": "NP_848739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848739", "type": "external" } ], "gene_names_uniprotkb": "Fbxl2", "gene_names_refseq": "2810423A21Rik; Fbl3; Fbxl2", "protein_names_uniprotkb": "F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2", "protein_names_refseq": "F-box/LRR-repeat protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72179)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21343341;21750661;22024926;23542741;23928698;25428507;25605945;28378753;31599954;34428180;36113884", "class_list": "", "function": "Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21343341, PubMed:23542741). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (By similarity). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (By similarity). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (By similarity). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (PubMed:21343341). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (PubMed:23542741). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (By similarity). The GGTase-3 complex, composed of PTAR1 and RABGGTB, geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the SCF(FBXL2) complex that mediates the degradation of membrane-anchored proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-alpha during Acute and Chronic Lung Allograft Rejection., [RefSeq, PubMed]; FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest., [RefSeq, PubMed]; FBXL2 mediates Aurora B ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrated that TRAF6 plays an important role in the process of aseptic inflammatory loosening caused by periprosthetic debris, and Low intensity pulsed ultrasound was found to inhibit such inflammation through increasing the level of FBXL2, and further increasing ubiquitination of TRAF6. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXM4", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019903 protein phosphatase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010506 regulation of autophagy;GO:0050727 regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BH16-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TPX4-1", "uniprot_id": [ { "id": "EXOC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TPX4", "type": "external" } ], "mass": 81738.0, "length": 708, "protein_name": "Exocyst complex component 5", "gene_name": "Exoc5", "organism": "Mouse", "refseq_name": "exocyst complex component 5", "refseq_ac": [ { "id": "NP_997097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997097", "type": "external" } ], "gene_names_uniprotkb": "Exoc5; Sec10l1", "gene_names_refseq": "Exoc5; Gm76; PRO1912; SEC10; Sec10l1", "protein_names_uniprotkb": "Exocyst complex component 5; Exocyst complex component Sec10", "protein_names_refseq": "SEC10-like 1; exocyst complex component 5; exocyst complex component Sec10", "tax_id": 10090, "disease": "obstructive nephropathy (Disease Ontology:DOID:0070314); bicuspid aortic valve disease (Disease Ontology:DOID:0080332)", "pathway": " (mmu:105504); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16452087;18480549;21183079;21750661;25605945;26040895;26046524;27802388;33647317;34064901;34428180;39037927", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function. Publication Status: Online-Only, [RefSeq, PubMed]; Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model., [RefSeq, PubMed]; Findings show exocyst complex component 5 protein Sec10 is critical for the development of the urothelium in ureters. Publication Status: Online-Only, [RefSeq, PubMed]; Oocyte-specific EXOC5 expression is required for mouse oogenesis and folliculogenesis., [RefSeq, PubMed]; Sec10-knockout mouse model revealed significant defects in renal tubule epithelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VK3", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030496 midbody;GO:0097546 ciliary base;GO:0000145 exocyst;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0015031 protein transport;GO:0072659 protein localization to plasma membrane;GO:0001822 kidney development;GO:0006915 apoptotic process;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3TPX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26883-1", "uniprot_id": [ { "id": "FKB1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P26883", "type": "external" } ], "mass": 11923.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1A", "gene_name": "Fkbp1a", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1A isoform 1", "refseq_ac": [ { "id": "NP_001289006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289006", "type": "external" } ], "gene_names_uniprotkb": "Fkbp1a; Fkbp1", "gene_names_refseq": "FKBP12; Fkbp1a; Fkbp1; Fkbp", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; 5.2.1.8; Calstabin-1; FK506-binding protein 1A; FKBP-12; FKBP-1A; Immunophilin FKBP12; PPIase FKBP1A; Rotamase", "protein_names_refseq": "FK506 binding protein 12; PPIase FKBP1A; calstabin-1; immunophilin FKBP12; peptidyl-prolyl cis-trans isomerase FKBP1A isoform 1; peptidyl-prolyl cis-trans isomerase FKBP1A", "tax_id": 10090, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (mmu:14225); (R-MMU-166208); (R-MMU-2025928); (R-MMU-2173789)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "11471062;11801660;16075062;1722474;18268335;21750661;23806337;25428506;30499712;30887568;32152506;33649389;34428180;36288343;37199280;37507081;37828378;39927985", "class_list": "", "function": "Cardiomyocyte-restricted overexpression of FKBP12 reduces the atrial Nav1.5 expression level and mean peak INa, which is associated with increased peak L-type Ca(2+) current and interstitial fibrosis in atria. The combined electrophysiological and structural changes facilitated the development of local conduction block and altered action potential duration and spontaneous AF. Erratum:[Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H938. doi: 10.1152/ajpheart.zh4-2716-corr.2019. PMID: 30946606], [RefSeq, PubMed]; FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes., [RefSeq, PubMed]; FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts., [RefSeq, PubMed]; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)., [UniProtKB]; This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545E9", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0043679 axon terminus;GO:0045202 synapse", "go_biological_process": "GO:0006936 muscle contraction;GO:0031000 response to caffeine;GO:0003007 heart morphogenesis;GO:0051209 release of sequestered calcium ion into cytosol;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P26883-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNA6-1", "uniprot_id": [ { "id": "FAT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNA6", "type": "external" } ], "mass": 502011.0, "length": 4555, "protein_name": "Protocadherin Fat 3", "gene_name": "Fat3", "organism": "Mouse", "refseq_name": "protocadherin Fat 3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001074283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074283", "type": "external" } ], "gene_names_uniprotkb": "Fat3; Gm1132; Gm510", "gene_names_refseq": "9430076A06Rik; D430038H04Rik; Fat3; Gm1132; Gm510; MFAT3F", "protein_names_uniprotkb": "Protocadherin Fat 3; FAT tumor suppressor homolog 3", "protein_names_refseq": "FAT tumor suppressor homolog 3; protocadherin Fat 3 isoform 2 precursor; protocadherin Fat 3; protocadherin Fat3", "tax_id": 10090, "disease": "", "pathway": " (mmu:270120)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16059920;17131403;21750661;21903076;22510986;24129315;30899004;31219806;36840844;40885482", "class_list": "", "function": "A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development., [RefSeq, PubMed]; Data find that during mouse development, Fat3 and Fat4 synergize to drive vertebral arch fusion at the dorsal midline during caudal vertebra morphogenesis., [RefSeq, PubMed]; May play a role in the interactions between neurites derived from specific subsets of neurons during development., [UniProtKB, UniProtKB, UniProtKB]; This study demonistrated that fat3 mutation in thr mice caused amacrine cell migration and retina development., [RefSeq, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 27, "binding_glycan_count": 0, "secondary_ac_list": "Q08ED4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030425 dendrite;GO:0043005 neuron projection", "go_biological_process": "GO:0016358 dendrite development;GO:0001764 neuron migration;GO:0000902 cell morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8BNA6-1", "record_type": "protein", "filter_code": "0000000.1000101.000100.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2Y3-1", "uniprot_id": [ { "id": "EVA1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2Y3", "type": "external" } ], "mass": 18291.0, "length": 164, "protein_name": "Protein eva-1 homolog B", "gene_name": "Eva1b", "organism": "Mouse", "refseq_name": "protein eva-1 homolog B", "refseq_ac": [ { "id": "NP_742157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742157", "type": "external" } ], "gene_names_uniprotkb": "Eva1b; Fam176b", "gene_names_refseq": "2610027C15Rik; Eva1b; Fam176b", "protein_names_uniprotkb": "Protein eva-1 homolog B; Protein FAM176B", "protein_names_refseq": "family with sequence similarity 176, member B; protein FAM176B; protein eva-1 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:230752)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AW02", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K2Y3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08689-1", "uniprot_id": [ { "id": "GDF8_MOUSE", "url": "https://www.uniprot.org/uniprot/O08689", "type": "external" } ], "mass": 42921.0, "length": 376, "protein_name": "Growth/differentiation factor 8", "gene_name": "Mstn", "organism": "Mouse", "refseq_name": "growth/differentiation factor 8 preproprotein", "refseq_ac": [ { "id": "NP_034964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034964", "type": "external" } ], "gene_names_uniprotkb": "Mstn; Gdf8", "gene_names_refseq": "Cmpt; Gdf8; Mstn", "protein_names_uniprotkb": "Growth/differentiation factor 8; GDF-8; Myostatin", "protein_names_refseq": "growth/differentiation factor 8 preproprotein; growth/differentiation factor 8", "tax_id": 10090, "disease": "vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418); myostatin-related muscle hypertrophy (Disease Ontology:DOID:0111072); hypothyroidism (Disease Ontology:DOID:1459); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); peripheral vascular disease (Disease Ontology:DOID:341); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:17700)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12595574;14671324;19644449;21750661;22052913;24076600;38136649;38185835;38748517;38889010;9139826", "class_list": "", "function": "Acts specifically as a negative regulator of skeletal muscle growth., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Myostatin and the Heart. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Myostatin gene invalidation does not prevent skeletal muscle mass loss during experimental sepsis in mice., [RefSeq, PubMed]; Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of modification of DNA interference on myostatin gene expression in mice., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014816 skeletal muscle satellite cell differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0045471 response to ethanol;GO:0046716 muscle cell cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08689-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMP6-1", "uniprot_id": [ { "id": "GCP60_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMP6", "type": "external" } ], "mass": 60181.0, "length": 525, "protein_name": "Golgi resident protein GCP60", "gene_name": "Acbd3", "organism": "Mouse", "refseq_name": "Golgi resident protein GCP60", "refseq_ac": [ { "id": "NP_573488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573488", "type": "external" } ], "gene_names_uniprotkb": "Acbd3; Gcp60; Pap7", "gene_names_refseq": "60kDa; 8430407O11Rik; Acbd3; D1Ertd10e; GCP60; GOLPH1; Gocap1; Pap7", "protein_names_uniprotkb": "Golgi resident protein GCP60; Acyl-CoA-binding domain-containing protein 3; GOCAP1; GOLPH1; Golgi complex-associated protein 1; Golgi phosphoprotein 1; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor-associated protein PAP7", "protein_names_refseq": "Golgi resident protein GCP60; PBR associated protein; PBR- and PKA-associated protein 7; acyl-CoA-binding domain-containing protein 3; golgi complex associated protein 1, 60 kDa; golgi complex-associated protein 1; golgi phosphoprotein 1; peripheral benzodiazepine receptor-associated protein PAP7; peripherial benzodiazepine receptor associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:170760); (R-MMU-432722)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11731621;12711385;14623258;21750661;25940138;33546322;34428180", "class_list": "", "function": "A Crucial Role of ACBD3 Required for Coxsackievirus Infection in Animal Model Developed by AAV-Mediated CRISPR Genome Editing Technique. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (PubMed:12711385). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; These findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function., [RefSeq, PubMed]; These results suggest that PBR, in addition to its role in cholesterol and coproporphyrinogen III transport, is also directing the mitochondrial PPIX import, a function that can be ascribed to the 18kDa PBR protein alone, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35371", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BMP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYY0-1", "uniprot_id": [ { "id": "GAB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYY0", "type": "external" } ], "mass": 76812.0, "length": 695, "protein_name": "GRB2-associated-binding protein 1", "gene_name": "Gab1", "organism": "Mouse", "refseq_name": "GRB2-associated-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_067331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067331", "type": "external" } ], "gene_names_uniprotkb": "Gab1", "gene_names_refseq": "Gab1", "protein_names_uniprotkb": "GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1", "protein_names_refseq": "GRB2-associated binder 1; GRB2-associated-binding protein 1 isoform 2; GRB2-associated-binding protein 1", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 26 (Disease Ontology:DOID:0110484)", "pathway": " (mmu:14388); (R-MMU-109704); (R-MMU-1257604); (R-MMU-180292); (R-MMU-1963642); (R-MMU-5654689); (R-MMU-5654695); (R-MMU-5654710); (R-MMU-5654720); (R-MMU-6811558); (R-MMU-8851907); (R-MMU-8853659); (R-MMU-8865999); (R-MMU-8875555); (R-MMU-8875656); (R-MMU-9027276)", "pathway_count": 16, "publication_count": 20, "publication_id_list": "10978177;11353842;20094046;21183079;21750661;22645316;23521888;29408807;31219806;32782141;32848054;34428180;34678516;35822049;36374360;36795486;36852467;38935609;40021952;40885482", "class_list": "", "function": "Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis. Publication Status: Online-Only, [RefSeq, PubMed]; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway., [UniProtKB, UniProtKB]; Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q91VW7", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0005938 cell cortex", "go_biological_process": "GO:0035728 response to hepatocyte growth factor;GO:0001525 angiogenesis;GO:0006979 response to oxidative stress;GO:0007165 signal transduction;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q9QYY0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26049-1", "uniprot_id": [ { "id": "GBRA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P26049", "type": "external" } ], "mass": 55398.0, "length": 492, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-3", "gene_name": "Gabra3", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032093", "type": "external" } ], "gene_names_uniprotkb": "Gabra3; Gabra-3", "gene_names_refseq": "Gabra-3; Gabra3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-3; GABA(A) receptor subunit alpha-3; GABAAR subunit alpha-3", "protein_names_refseq": "GABA(A) receptor subunit alpha-3; GABAAR subunit alpha-3; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3; gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor; gamma-aminobutyric acid receptor subunit alpha-3", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (mmu:14396); (R-MMU-977443)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11528422;1356407;17114649;17369310;21183079;21750661;30899004", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0045202 synapse;GO:0098794 postsynapse;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P26049-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVA8-1", "uniprot_id": [ { "id": "GCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVA8", "type": "external" } ], "mass": 293021.0, "length": 2671, "protein_name": "Stalled ribosome sensor GCN1", "gene_name": "Gcn1", "organism": "Mouse", "refseq_name": "stalled ribosome sensor GCN1", "refseq_ac": [ { "id": "NP_766307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766307", "type": "external" } ], "gene_names_uniprotkb": "Gcn1; Gcn1l1", "gene_names_refseq": "4932409G22; G431004K08Rik; GCN1L; Gcn1l1; Gcn1; mKIAA0219", "protein_names_uniprotkb": "Stalled ribosome sensor GCN1; GCN1 eIF-2-alpha kinase activator homolog; GCN1-like protein 1; General control of amino-acid synthesis 1-like protein 1; Translational activator GCN1", "protein_names_refseq": "GCN1 eIF-2-alpha kinase activator homolog; GCN1 general control of amino-acid synthesis 1-like 1; GCN1-like protein 1; eIF-2-alpha kinase activator GCN1; general control of amino-acid synthesis 1-like protein 1; stalled ribosome sensor GCN1; translational activator GCN1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231659)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15937339;22404850;23447528;24333428;25428506;30779550;32324833;33300544;34203471;34428180;34887587;35820727;36210013;37828378", "class_list": "", "function": "Loss of GCN1 causes severe growth retardation and embryonic lethality. GCN1 regulates the eIF2alpha-mediated stress response, cell cycle and cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (By similarity). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (By similarity). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (PubMed:15937339, PubMed:24333428, PubMed:32324833). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (PubMed:24333428, PubMed:32324833). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:24333428, PubMed:32324833)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RWW6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0055106 ubiquitin-protein transferase regulator activity;GO:0019887 protein kinase regulator activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0170011 stalled ribosome sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006417 regulation of translation;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0034198 cellular response to amino acid starvation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "E9PVA8-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88741-1", "uniprot_id": [ { "id": "GDAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88741", "type": "external" } ], "mass": 41311.0, "length": 358, "protein_name": "Ganglioside-induced differentiation-associated protein 1", "gene_name": "Gdap1", "organism": "Mouse", "refseq_name": "ganglioside-induced differentiation-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_034397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034397", "type": "external" } ], "gene_names_uniprotkb": "Gdap1", "gene_names_refseq": "Gdap1", "protein_names_uniprotkb": "Ganglioside-induced differentiation-associated protein 1; GDAP1", "protein_names_refseq": "ganglioside-induced differentiation-associated protein 1 isoform 1", "tax_id": 10090, "disease": "autosomal recessive axonal Charcot-Marie-Tooth disease with vocal cord paresis (Disease Ontology:DOID:0051028); Charcot-Marie-Tooth disease axonal type 2K (Disease Ontology:DOID:0110167); Charcot-Marie-Tooth disease axonal type 2C (Disease Ontology:DOID:0110182); Charcot-Marie-Tooth disease type 4A (Disease Ontology:DOID:0110185); Charcot-Marie-Tooth disease recessive intermediate A (Disease Ontology:DOID:0110201); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (mmu:14545); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10217254;16172208;18021315;21750661;24480485;33372681", "class_list": "", "function": "Cell expression of Gdap1 in the nervous system and pathogenesis of Charcot-Marie-Tooth type 4A disease are reported., [RefSeq, PubMed]; Members of the GDAP1 family are responsive and protective against stress associated with increased levels of oxidized glutathione., [RefSeq, PubMed]; Mitochondria-lysosome membrane contacts are defective in GDAP1-related Charcot-Marie-Tooth disease., [RefSeq, PubMed]; Regulates the mitochondrial network by promoting mitochondrial fission., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7Q5;Q9CTN2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032526 response to retinoic acid;GO:0006626 protein targeting to mitochondrion;GO:0008053 mitochondrial fusion;GO:0000266 mitochondrial fission;GO:0071305 cellular response to vitamin D", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88741-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22723-1", "uniprot_id": [ { "id": "GBRG2_MOUSE", "url": "https://www.uniprot.org/uniprot/P22723", "type": "external" } ], "mass": 55099.0, "length": 474, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-2", "gene_name": "Gabrg2", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032099", "type": "external" } ], "gene_names_uniprotkb": "Gabrg2", "gene_names_refseq": "GABAA-R; Gabrg-2; Gabrg2; gamma2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2", "protein_names_refseq": "GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2; gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); familial febrile seizures 8 (Disease Ontology:DOID:0111298); developmental and epileptic encephalopathy 74 (Disease Ontology:DOID:0112210); hepatic encephalopathy (Disease Ontology:DOID:13413); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); amphetamine abuse (Disease Ontology:DOID:670); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14406); (R-MMU-977443)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11003197;15207850;15229235;17151279;18281286;1846404;24213971;25172774;27129275;28279354;28978485;29742426;30899004;31601770;33300544;35820727", "class_list": "", "function": "Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:18281286, PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (PubMed:18281286)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q91V50;Q91VA8", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0030534 adult behavior;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:0009791 post-embryonic development;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P22723-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43028-1", "uniprot_id": [ { "id": "GDF6_MOUSE", "url": "https://www.uniprot.org/uniprot/P43028", "type": "external" } ], "mass": 50942.0, "length": 454, "protein_name": "Growth/differentiation factor 6", "gene_name": "Gdf6", "organism": "Mouse", "refseq_name": "growth/differentiation factor 6 preproprotein", "refseq_ac": [ { "id": "NP_038554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038554", "type": "external" } ], "gene_names_uniprotkb": "Gdf6; Bmp13; Gdf-6; Gdf16", "gene_names_refseq": "BMP-13; BMP13; GDF16; Gdf6", "protein_names_uniprotkb": "Growth/differentiation factor 6; BMP-13; Bone morphogenetic protein 13; GDF-6; Growth/differentiation factor 16", "protein_names_refseq": "GDF-6; bone morphogenetic protein 13; growth/differentiation factor 16; growth/differentiation factor 6 preproprotein", "tax_id": 10090, "disease": "isolated microphthalmia 4 (Disease Ontology:DOID:0060836); Klippel-Feil syndrome 1 (Disease Ontology:DOID:0080589); multiple synostoses syndrome 4 (Disease Ontology:DOID:0081320); Leber congenital amaurosis 17 (Disease Ontology:DOID:0110217); microphthalmia (Disease Ontology:DOID:10629); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:242316)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12606286;16049014;23307924;23527555;24076600;26774823;32369452;34428180;35442524;36744814;8145850", "class_list": "", "function": "Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis., [RefSeq, PubMed]; Defective Joint Development and Maintenance in GDF6-Related Multiple Synostoses Syndrome., [RefSeq, PubMed]; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures (PubMed:26774823). Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:12606286, PubMed:16049014). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (PubMed:23527555)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Role of single and double mutations in the mouse Gdf6 and Gdf5 genes in multiple joint and skeletal patterning defects, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mice lacking a functional copy of this gene exhibit joint and skeletal defects. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q70UT4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016477 cell migration;GO:0045666 positive regulation of neuron differentiation;GO:0006915 apoptotic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P43028-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97737-1", "uniprot_id": [ { "id": "GDF10_MOUSE", "url": "https://www.uniprot.org/uniprot/P97737", "type": "external" } ], "mass": 52575.0, "length": 476, "protein_name": "Growth/differentiation factor 10", "gene_name": "Gdf10", "organism": "Mouse", "refseq_name": "growth/differentiation factor 10 preproprotein", "refseq_ac": [ { "id": "NP_665684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665684", "type": "external" } ], "gene_names_uniprotkb": "Gdf10; Bmp3b", "gene_names_refseq": "Bmp3b; Gdf10", "protein_names_uniprotkb": "Growth/differentiation factor 10; BMP-3B; Bone morphogenetic protein 3B; GDF-10", "protein_names_refseq": "bone morphogenetic protein 3b; growth/differentiation factor 10 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14560)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10419686;14687547;21712809;22155034;24963847;8679252", "class_list": "", "function": "Gdf10 is expressed in Bergmann glia and is reduced in staggerer mice., [RefSeq, PubMed]; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034). Plays an inhibitory role in the process of adipogenesis (PubMed:21712809)., [UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein has been shown to promote neural repair after stroke and may act as a tumor suppressor. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE07", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0045444 fat cell differentiation;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0045669 positive regulation of osteoblast differentiation;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97737-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07104-1", "uniprot_id": [ { "id": "GDF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07104", "type": "external" } ], "mass": 41586.0, "length": 366, "protein_name": "Growth/differentiation factor 3", "gene_name": "Gdf3", "organism": "Mouse", "refseq_name": "growth/differentiation factor 3 preproprotein", "refseq_ac": [ { "id": "NP_032134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032134", "type": "external" } ], "gene_names_uniprotkb": "Gdf3; Gdf-3; Vgr-2", "gene_names_refseq": "Gdf-3; Gdf3; Vgr-2; Vgr2; ecat9", "protein_names_uniprotkb": "Growth/differentiation factor 3; GDF-3; VG-1-related protein 2", "protein_names_refseq": "VG-1-related protein 2; growth/differentiation factor 3 preproprotein", "tax_id": 10090, "disease": "isolated microphthalmia 7 (Disease Ontology:DOID:0060838); Klippel-Feil syndrome 3 (Disease Ontology:DOID:0080591)", "pathway": " (mmu:14562)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11396990;1480182;16368929;17936261;18480259;31947892;33830083;34418053;34428180;36484260;8429021", "class_list": "", "function": "Brd4 modulates diet-induced obesity via PPARgamma-dependent Gdf3 expression in adipose tissue macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (PubMed:16368929, PubMed:17936261). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO., [UniProtKB, PubMed, PubMed, PubMed]; Novel Cardiokine GDF3 Predicts Adverse Fibrotic Remodeling After Myocardial Infarction., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is important in embryogenesis and likely plays a role ocular and skeletal development. Mice lacking a functional copy of this gene exhibit defects in early embryonic development resulting in embryonic lethality. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUX1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0045605 negative regulation of epidermal cell differentiation;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0045600 positive regulation of fat cell differentiation;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q07104-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1W4-1", "uniprot_id": [ { "id": "GDF11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1W4", "type": "external" } ], "mass": 44947.0, "length": 405, "protein_name": "Growth/differentiation factor 11", "gene_name": "Gdf11", "organism": "Mouse", "refseq_name": "growth/differentiation factor 11 preproprotein", "refseq_ac": [ { "id": "NP_034402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034402", "type": "external" } ], "gene_names_uniprotkb": "Gdf11; Bmp11", "gene_names_refseq": "BMP-11; Bmp11; Gdf11", "protein_names_uniprotkb": "Growth/differentiation factor 11; BMP-11; Bone morphogenetic protein 11; GDF-11", "protein_names_refseq": "GDF-11; bone morphogenetic protein 11; growth/differentiation factor 11 preproprotein", "tax_id": 10090, "disease": "vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418)", "pathway": " (mmu:14561)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10072786;10075854;10391213;12414726;15988002;16845371;18378898;38920138", "class_list": "", "function": "GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS., [RefSeq, PubMed]; Secreted signal that acts globally to regulate anterior/posterior axial patterning during development (PubMed:10391213). May play critical roles in patterning both mesodermal and neural tissues (PubMed:10391213). It is required for proper vertebral patterning and orofacial development (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:12414726, PubMed:16845371)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The selectivity of PC5/6 for Gdf11 essentially resides in the presence of a P1' Asn in the RSRR downward arrowN cleavage motif, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. Mice lacking a functional copy of this gene exhibit impaired anteroposterior patterning and other developmental defects. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QX55;Q9R221", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045665 negative regulation of neuron differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z1W4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1Z0-1", "uniprot_id": [ { "id": "COQ9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1Z0", "type": "external" } ], "mass": 35083.0, "length": 313, "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "Coq9", "organism": "Mouse", "refseq_name": "ubiquinone biosynthesis protein COQ9, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080728", "type": "external" } ], "gene_names_uniprotkb": "Coq9", "gene_names_refseq": "2310005O14Rik; Coq9", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "protein_names_refseq": "coenzyme Q9 homolog; ubiquinone biosynthesis protein COQ9, mitochondrial precursor; ubiquinone biosynthesis protein COQ9, mitochondrial", "tax_id": 10090, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 5 (Disease Ontology:DOID:0070242)", "pathway": " (mmu:67914); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;17208939;17242355;18614015;21183079;21447381;21750661;23150520;23255162;23576753;25339443;25802402;31219806;34428180;36288343;37453647;37507081;39927985", "class_list": "", "function": "Although Pdss2 mutant mice manifest widespread CoQ(9) deficiency and mitochondrial respiratory chain abnormalities, only affected organs show increased ROS production, oxidative stress, mitochondrial DNA depletion, and reduced citrate synthase activity., [RefSeq, PubMed]; Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues, [RefSeq, PubMed]; Lack of a functional Coq9 protein causes predominant encephalomyopathy and CoQ deficiency., [RefSeq, PubMed]; Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis., [RefSeq, PubMed]; The presence of a truncated version of COQ9 protein in Coq9(R239X) mice destabilizes the coenzyme Q10-synthesizing multiprotein complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CT61", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0019840 isoprenoid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8K1Z0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHN0-1", "uniprot_id": [ { "id": "PPM1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHN0", "type": "external" } ], "mass": 41049.0, "length": 360, "protein_name": "Protein phosphatase 1L", "gene_name": "Ppm1l", "organism": "Mouse", "refseq_name": "protein phosphatase 1L", "refseq_ac": [ { "id": "NP_848841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848841", "type": "external" } ], "gene_names_uniprotkb": "Ppm1l; Kiaa4175", "gene_names_refseq": "3222401G13; 5930404J21Rik; PP2Cepsilon; PP2C; Pp2ce; Ppm1l; Ppp2ce; mKIAA4175", "protein_names_uniprotkb": "Protein phosphatase 1L; 3.1.3.16; PP2C-epsilon; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon", "protein_names_refseq": "PP2C-epsilon; protein phosphatase 1-like; protein phosphatase 1L; protein phosphatase 2C epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:242083)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12556533;17456047;18165232;18344982;25369058;26495903;27680501;32152506;34428180", "class_list": "", "function": "Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6., [UniProtKB, PubMed]; CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus., [RefSeq, PubMed]; In the absence of IL-1-induced signal, PP2Cepsilon contributes to keeping the TAK1 signaling pathway in an inactive state by associating with and dephosphorylating TAK1., [RefSeq, PubMed]; Study provided evidence that PPM1L is involved in the development of the central nervous system., [RefSeq, PubMed]; This study provides the first in vivo evidence that PP2Ce is an essential regulator of normal lactation, possibly involving IRE1 signaling and endoplasmic reticulum stress regulation in mammary epithelium. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGL2;Q810H0;Q8C021;Q8C1D5;Q9Z0T1", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0000165 MAPK cascade;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BHN0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62245-1", "uniprot_id": [ { "id": "SOS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62245", "type": "external" } ], "mass": 150883.0, "length": 1319, "protein_name": "Son of sevenless homolog 1", "gene_name": "Sos1", "organism": "Mouse", "refseq_name": "son of sevenless homolog 1", "refseq_ac": [ { "id": "NP_033257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033257", "type": "external" } ], "gene_names_uniprotkb": "Sos1", "gene_names_refseq": "4430401P03Rik; 9630010N06; Sos1", "protein_names_uniprotkb": "Son of sevenless homolog 1; SOS-1; mSOS-1", "protein_names_refseq": "guanine nucleotide releasing factor; ras guanine exchange factor; son of sevenless homolog 1; son-of-sevenless 1", "tax_id": 10090, "disease": "gingival fibromatosis (Disease Ontology:DOID:0060466); Noonan syndrome 4 (Disease Ontology:DOID:0060582); prostate cancer (Disease Ontology:DOID:10283); atrial heart septal defect (Disease Ontology:DOID:1882); brain ischemia (Disease Ontology:DOID:2316); Noonan syndrome (Disease Ontology:DOID:3490); cerebral infarction (Disease Ontology:DOID:3526); cervical cancer (Disease Ontology:DOID:4362); pulmonary valve stenosis (Disease Ontology:DOID:6420)", "pathway": " (mmu:20662); (R-MMU-112412); (R-MMU-1250347); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-167044); (R-MMU-179812); (R-MMU-180336); (R-MMU-186763); (R-MMU-193648); (R-MMU-1963640); (R-MMU-210993); (R-MMU-2179392); (R-MMU-2424491); (R-MMU-2428933); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-354194); (R-MMU-375165); (R-MMU-416482); (R-MMU-5654688); (R-MMU-5654693); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5673001); (R-MMU-74749); (R-MMU-74751); (R-MMU-8851805); (R-MMU-8853659); (R-MMU-8983432); (R-MMU-9013149); (R-MMU-9028731); (R-MMU-912526); (R-MMU-9607240); (R-MMU-983695); (R-MMU-9842663)", "pathway_count": 41, "publication_count": 18, "publication_id_list": "10499589;10671200;11524436;1631150;17114649;17242355;21183079;25428506;30084848;31219806;34203471;34428180;36103132;36210013;36446400;36453576;37730692;9217262", "class_list": "", "function": "Critical requirement of SOS1 for tumor development and microenvironment modulation in KRAS[G12D]-driven lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice., [RefSeq, PubMed]; PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1., [RefSeq, PubMed]; Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:10499589, PubMed:11524436)., [UniProtKB, PubMed, PubMed, UniProtKB]; Son of sevenless 1 (SOS1), the RasGEF, interacts with ERalpha and STAT3 during embryo implantation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62244", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0033081 regulation of T cell differentiation in thymus;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0002260 lymphocyte homeostasis;GO:0007296 vitellogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62245-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05480-2", "uniprot_id": [ { "id": "SRC_MOUSE", "url": "https://www.uniprot.org/uniprot/P05480", "type": "external" } ], "mass": 59891.0, "length": 535, "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "Src", "organism": "Mouse", "refseq_name": "proto-oncogene tyrosine-protein kinase Src isoform 2", "refseq_ac": [ { "id": "NP_001020566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020566", "type": "external" } ], "gene_names_uniprotkb": "Src", "gene_names_refseq": "Src; pp60c-src", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase Src; 2.7.10.2; Proto-oncogene c-Src; p60-Src; pp60c-src", "protein_names_refseq": "Rous sarcoma oncogene; neuronal proto-oncogene tyrosine-protein kinase Src; p60-Src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src isoform 2", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); lesion of sciatic nerve (Disease Ontology:DOID:12528); colon carcinoma (Disease Ontology:DOID:1520); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); Williams-Beuren syndrome (Disease Ontology:DOID:1928); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); Goldenhar syndrome (Disease Ontology:DOID:2907); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic acinar cell adenocarcinoma (Disease Ontology:DOID:5742); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20779); (R-MMU-1227986); (R-MMU-1251985); (R-MMU-1253288); (R-MMU-1257604); (R-MMU-1295596); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-177929); (R-MMU-180292); (R-MMU-186763); (R-MMU-191650); (R-MMU-2029481); (R-MMU-210990); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-389356); (R-MMU-389513); (R-MMU-3928662); (R-MMU-3928663); (R-MMU-3928664); (R-MMU-3928665); (R-MMU-418592); (R-MMU-418594); (R-MMU-418885); (R-MMU-430116); (R-MMU-437239); (R-MMU-4420097); (R-MMU-456926); (R-MMU-5218921); (R-MMU-5607764); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-6811558); (R-MMU-69231); (R-MMU-8853659); (R-MMU-8874081); (R-MMU-8934903); (R-MMU-8941858); (R-MMU-9009391); (R-MMU-9603381); (R-MMU-9766229); (R-MMU-9958810)", "pathway_count": 44, "publication_count": 52, "publication_id_list": "10.1101/2023.09.13.557529;11433297;11964124;12115541;12615910;12925710;14644164;14739300;15546918;16236242;16684964;16828070;17000758;17517963;18034455;18044967;19122674;19144319;20093046;21183079;21199370;21525037;21901128;22801373;22872234;2440106;2474754;25097454;25428506;25731159;26551526;27572515;29472430;29775473;31073117;31219806;32139394;33037073;34105348;34428180;36210013;37828378;38346942;38755258;7542762;7681396;8641341;8672527;8910389;9344858;9442882;9819391", "class_list": "", "function": "Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis., [RefSeq, PubMed]; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (By similarity). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (PubMed:9344858). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation (By similarity). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (By similarity). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). Upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, active SRC is recruited, together with the phosphatase DUSP18, to the KISS1R C-terminus. This leads to DUSP18-mediated SRC dephosphorylation and inactivation, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances RIGI-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (By similarity). Required for podosome formation (PubMed:21525037). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (By similarity). Mediates laminin-induced activation of RAC1 signaling through phosphorylation of syntrophin (PubMed:18044967)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity., [UniProtKB, UniProtKB]; Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-418 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8WI90;Q2M4I4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0071253 connexin binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0099073 mitochondrion-derived vesicle;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:2000641 regulation of early endosome to late endosome transport;GO:0046579 positive regulation of Ras protein signal transduction;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0071897 DNA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P05480-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPK5-1", "uniprot_id": [ { "id": "WWTR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPK5", "type": "external" } ], "mass": 43620.0, "length": 395, "protein_name": "WW domain-containing transcription regulator protein 1", "gene_name": "Wwtr1", "organism": "Mouse", "refseq_name": "WW domain-containing transcription regulator protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001161753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161753", "type": "external" } ], "gene_names_uniprotkb": "Wwtr1; Taz", "gene_names_refseq": "2310058J06Rik; 2610021I22Rik; Taz; Wwtr1", "protein_names_uniprotkb": "WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motif", "protein_names_refseq": "WW domain-containing transcription regulator protein 1 isoform 1; WW domain-containing transcription regulator protein 1; transcriptional coactivator with PDZ-binding motif", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); heart disease (Disease Ontology:DOID:114); nephronophthisis (Disease Ontology:DOID:12712); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (mmu:97064); (R-MMU-2028269); (R-MMU-2032785); (R-MMU-2173796)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11118213;12529404;14970209;16099986;17242355;17251353;21145499;21183079;25428506;30059200;31599954;32782141;34428180;37215988", "class_list": "", "function": "Coactivates Runx2-dependent gene transcription while repressing PPARgamma-dependent gene transcription; results indicate that TAZ functions as a molecular rheostat that modulates mesenchymal stem cell differentiation, [RefSeq, PubMed]; TAZ interacts with TTF-1 and regulates expression of surfactant protein-C, [RefSeq, PubMed]; TAZ is a transcription coactivator for Cbfa1 and may be involved in the regulation of osteoblast differentiation., [RefSeq, PubMed]; This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]., [RefSeq]; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:37215988). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (By similarity). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Wwtr1 is critical for the integrity of renal cilia and its absence in mice leads to the development of renal cysts, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ69;Q3UQM0;Q99KI4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0060993 kidney morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9EPK5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXH3-1", "uniprot_id": [ { "id": "GPBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NXH3", "type": "external" } ], "mass": 53423.0, "length": 473, "protein_name": "Vasculin", "gene_name": "Gpbp1", "organism": "Mouse", "refseq_name": "vasculin isoform 1", "refseq_ac": [ { "id": "NP_001116435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116435", "type": "external" } ], "gene_names_uniprotkb": "Gpbp1; Gpbp", "gene_names_refseq": "1700034P14Rik; D230035M11Rik; Gpbp1; Gpbp; mGPBP", "protein_names_uniprotkb": "Vasculin; GC-rich promoter-binding protein 1; mGPBP", "protein_names_refseq": "vasculin isoform 1; vasculin", "tax_id": 10090, "disease": "", "pathway": " (mmu:73274)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14612417;19144319;21183079;21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "Binds specifically to the adenosine deaminase gene promoter, [RefSeq, PubMed]; Functions as a GC-rich promoter-specific transactivating transcription factor., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQR2;Q3TSN7;Q6TYE7;Q8C498;Q8R252", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6NXH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C156-1", "uniprot_id": [ { "id": "CND2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C156", "type": "external" } ], "mass": 82303.0, "length": 731, "protein_name": "Condensin complex subunit 2", "gene_name": "Ncaph", "organism": "Mouse", "refseq_name": "condensin complex subunit 2", "refseq_ac": [ { "id": "NP_659067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659067", "type": "external" } ], "gene_names_uniprotkb": "Ncaph; Brrn1; Brrn; Caph", "gene_names_refseq": "A730011O11Rik; Brrn1; CAP-H; HCAP-H; Ncaph; mCAP-H", "protein_names_uniprotkb": "Condensin complex subunit 2; Barren homolog protein 1; Chromosome-associated protein H; Non-SMC condensin I complex subunit H; XCAP-H homolog; mCAP-H", "protein_names_refseq": "XCAP-H homolog; barren homolog protein 1; chromosome-associated protein H; condensin complex subunit 2", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 23 (Disease Ontology:DOID:0051034); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:215387); (R-MMU-2514853)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;21750661;25153642;25428506;28135057;28528544;30084848;36642844;36852467;39627609", "class_list": "", "function": "Non-SMC condensin I complex subunit H participates in anti-programmed cell death-1 resistance of clear cell renal cell carcinomas., [RefSeq, PubMed]; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY01;Q8VDM9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C156-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11087-1", "uniprot_id": [ { "id": "CO1A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P11087", "type": "external" } ], "mass": 138032.0, "length": 1453, "protein_name": "Collagen alpha-1(I) chain", "gene_name": "Col1a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(I) chain preproprotein", "refseq_ac": [ { "id": "NP_031768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031768", "type": "external" } ], "gene_names_uniprotkb": "Col1a1; Cola1", "gene_names_refseq": "Col1a-1; Col1a1; Cola-1; Cola1; Mov-13; Mov13", "protein_names_uniprotkb": "Collagen alpha-1(I) chain; Alpha-1 type I collagen", "protein_names_refseq": "alpha-1 type 1 collagen; alpha-1 type I collagen; collagen alpha-1(I) chain preproprotein; collagen alpha-1(I) chain; procollagen, type I, alpha 1", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); chronic pancreatitis (Disease Ontology:DOID:0051065); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Ehlers-Danlos syndrome arthrochalasia type 1 (Disease Ontology:DOID:0080727); osteogenesis imperfecta type 1 (Disease Ontology:DOID:0110334); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); osteogenesis imperfecta (Disease Ontology:DOID:12347); alcoholic hepatitis (Disease Ontology:DOID:12351); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); thoracic aortic aneurysm (Disease Ontology:DOID:14004); aggressive periodontitis (Disease Ontology:DOID:1474); multiple sclerosis (Disease Ontology:DOID:2377); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); pulmonary fibrosis (Disease Ontology:DOID:3770); dentinogenesis imperfecta (Disease Ontology:DOID:4154); systemic scleroderma (Disease Ontology:DOID:418); Caffey disease (Disease Ontology:DOID:4257); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); ulcerative colitis (Disease Ontology:DOID:8577); degenerative disc disease (Disease Ontology:DOID:90); cutaneous leishmaniasis (Disease Ontology:DOID:9111); liver benign neoplasm (Disease Ontology:DOID:916); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12842)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;17330941;2054384;24028588;25428506;25645914;26495903;27119146;28011936;29148101;30899004;3340560;34428180;34887587;36288343;3841523;6219867;6298597;6324198;8065328;8268229;8535610", "class_list": "", "function": "This gene encodes the alpha-1 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing. [provided by RefSeq, Nov 2015]., [RefSeq]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 37, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q53WT0;Q60635;Q61367;Q61427;Q63919;Q6PCL3;Q810J9", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0031012 extracellular matrix", "go_biological_process": "GO:0015031 protein transport;GO:0030335 positive regulation of cell migration;GO:0071300 cellular response to retinoic acid;GO:0071333 cellular response to glucose stimulus;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P11087-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R194-1", "uniprot_id": [ { "id": "CRY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R194", "type": "external" } ], "mass": 66850.0, "length": 592, "protein_name": "Cryptochrome-2", "gene_name": "Cry2", "organism": "Mouse", "refseq_name": "cryptochrome-2", "refseq_ac": [ { "id": "NP_034093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034093", "type": "external" } ], "gene_names_uniprotkb": "Cry2; Kiaa0658", "gene_names_refseq": "Cry2; D130054K12Rik", "protein_names_uniprotkb": "Cryptochrome-2", "protein_names_refseq": "cryptochrome 2 (photolyase-like); cryptochrome-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12953)", "pathway_count": 1, "publication_count": 44, "publication_id_list": "10428031;10521578;11779462;11875063;14701732;15298678;15980066;16628007;16687286;16717091;17274955;17310242;17462724;19299583;19917250;20123978;20840750;20852621;22170608;22798407;23303907;23452855;23452856;23503662;23531614;23575670;23616524;23916625;24080726;24154698;24158435;24736997;25288642;26776516;27123980;28683290;28751364;29561690;34678516;37434265;37797722;37951306;39012854;9801304", "class_list": "", "function": "CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4., [RefSeq, PubMed]; CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice. Publication Status: Online-Only, [RefSeq, PubMed]; CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability. Publication Status: Online-Only, [RefSeq, PubMed]; Functional characterization of the CRY2 circadian clock component variant p.Ser420Phe revealed a new degradation pathway for CRY2., [RefSeq, PubMed]; This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and NAMPT. Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (PubMed:28683290). Represses the transcriptional activity of NR1I2 (PubMed:28751364)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08706;Q6A024", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0071949 FAD binding;GO:0003684 damaged DNA binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:2000850 negative regulation of glucocorticoid secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "Q9R194-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01193-1", "uniprot_id": [ { "id": "COLI_MOUSE", "url": "https://www.uniprot.org/uniprot/P01193", "type": "external" } ], "mass": 26707.0, "length": 235, "protein_name": "Pro-opiomelanocortin", "gene_name": "Pomc", "organism": "Mouse", "refseq_name": "pro-opiomelanocortin preproprotein", "refseq_ac": [ { "id": "NP_001265510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265510", "type": "external" } ], "gene_names_uniprotkb": "Pomc; Pomc1", "gene_names_refseq": "ACTH; BE; Beta-LPH; Clip; Gamma-LPH; Npp; Pomc-1; Pomc1; Pomc; alpha-MSH; alphaMSH; beta-MSH; gamma-MSH", "protein_names_uniprotkb": "Pro-opiomelanocortin; ACTH; Adrenocorticotropic hormone; Beta-LPH; Corticotropin-lipotropin; Gamma-LPH; Gamma-MSH; Melanotropin alpha; Melanotropin beta; POMC", "protein_names_refseq": "adrenal corticotropic hormone; adrenocorticotropic hormone; alpha-melanocyte stimulating hormone; beta-endorphin; corticotropin-like intermediary peptide; corticotropin-lipotropin; melanotropin gamma; met-enkephalin; pro-opiomelanocortin preproprotein", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Wernicke-Korsakoff syndrome (Disease Ontology:DOID:10915); hyperandrogenism (Disease Ontology:DOID:11613); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18976); (R-MMU-111885); (R-MMU-193048); (R-MMU-194002); (R-MMU-202040); (R-MMU-209952); (R-MMU-211976); (R-MMU-375276); (R-MMU-418555); (R-MMU-418594)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;1618797;1689057;21750661;221916;2536749;25707796;30899004;35926007;6303853;6308009;9413988", "class_list": "", "function": "Endogenous opiate., [UniProtKB]; Endogenous orexigenic opiate., [UniProtKB]; Functions as a ligand for the melanocortin receptors MC1R, MC2R, MC3R and MC5R (PubMed:9413988). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair. Binding to MC2R stimulates the adrenal glands to secrete cortisol. Contributes to the regulation of energy homeostasis through activation of MC3R (By similarity). Involved in the regulation exocrine gland function through MC5R activation (PubMed:9413988)., [UniProtKB, UniProtKB, PubMed]; Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serves as a ligand for the melanocortin receptors MC1R, MC3R, MC4R and MC5R (PubMed:35926007, PubMed:9413988). Activation of MC1R promotes melanogenesis in melanocytes of the skin and hair. Contributes to the regulation of energy homeostasis through activation of MC3R. Through MC4R activation, functions as an anorexigenic peptide (By similarity). Promotes immunosuppression and involved in the regulation exocrine gland function through MC5R activation (PubMed:35926007, PubMed:9413988)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P01200;Q544U4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031781 type 3 melanocortin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix;GO:0030141 secretory granule", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0005981 regulation of glycogen catabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P01193-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SU73-1", "uniprot_id": [ { "id": "COIL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SU73", "type": "external" } ], "mass": 61917.0, "length": 570, "protein_name": "Coilin", "gene_name": "Coil", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Coil; CLN80", "gene_names_refseq": "", "protein_names_uniprotkb": "Coilin; p80-coilin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:12812)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10806077;21183079;21750661;31219806", "class_list": "", "function": "Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK39;Q8K0K5;Q8VIQ2;Q9QXI1", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0030620 U2 snRNA binding;GO:0042802 identical protein binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0016604 nuclear body", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5SU73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0S5-1", "uniprot_id": [ { "id": "CLD15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0S5", "type": "external" } ], "mass": 24280.0, "length": 227, "protein_name": "Claudin-15", "gene_name": "Cldn15", "organism": "Mouse", "refseq_name": "claudin-15", "refseq_ac": [ { "id": "NP_068365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068365", "type": "external" } ], "gene_names_uniprotkb": "Cldn15", "gene_names_refseq": "2210009B08Rik; Cldn15", "protein_names_uniprotkb": "Claudin-15", "protein_names_refseq": "claudin-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:60363)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16505581;18242218;20727355;21183079;23089202;24744376;31936130;37100833", "class_list": "", "function": "Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:18242218, PubMed:20727355, PubMed:23089202, PubMed:37100833). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (PubMed:18242218, PubMed:20727355, PubMed:23089202, PubMed:37100833)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Na(+)-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na(+) Recycling in Mouse Small Intestine. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of claudin-15 deletion on cationic selectivity and transport in paracellular pathways of the cecum and large intestine. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein increases permeability for sodium ions in anion-selective epithelial cell sheets. The gene deficiency leads to megaintestine and decreases in intestinal epithelial paracellular ion permeability. This gene is a direct target for hepatocyte-nuclear-factor-4alpha, a mediator of ion epithelial transport, and is down-modulated in inflammatory bowel disease. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7Z0;Q9D8A6", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0070160 tight junction", "go_biological_process": "GO:1904729 regulation of intestinal lipid absorption;GO:0006811 monoatomic ion transport;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0160184 paracellular transport;GO:1903985 regulation of intestinal D-glucose absorption", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z0S5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35235-2", "uniprot_id": [ { "id": "PTN11_MOUSE", "url": "https://www.uniprot.org/uniprot/P35235", "type": "external" } ], "mass": 68035.0, "length": 593, "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "Ptpn11", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 11 isoform b", "refseq_ac": [ { "id": "NP_001103462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103462", "type": "external" } ], "gene_names_uniprotkb": "Ptpn11", "gene_names_refseq": "2700084A17Rik; PTP1D; PTP2C; Ptpn11; SAP-2; SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 11; 3.1.3.48; Protein-tyrosine phosphatase SYP; SH-PTP2; SHP-2; Shp2", "protein_names_refseq": "SH2 domain-containing protein tyrosine phosphatase-2; protein-tyrosine phosphatase SYP; tyrosine-protein phosphatase non-receptor type 11 isoform b; tyrosine-protein phosphatase non-receptor type 11", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); hepatocellular adenoma (Disease Ontology:DOID:0050868); idiopathic scoliosis (Disease Ontology:DOID:0060250); Noonan syndrome 1 (Disease Ontology:DOID:0060578); Noonan syndrome with multiple lentigines 1 (Disease Ontology:DOID:0080548); metachondromatosis (Disease Ontology:DOID:0111512); stomach cancer (Disease Ontology:DOID:10534); anogenital venereal wart (Disease Ontology:DOID:11168); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); Noonan syndrome with multiple lentigines (Disease Ontology:DOID:14291); glaucoma (Disease Ontology:DOID:1686); chondroma (Disease Ontology:DOID:2602); Noonan syndrome (Disease Ontology:DOID:3490); cervical cancer (Disease Ontology:DOID:4362); tetralogy of Fallot (Disease Ontology:DOID:6419); atrophic gastritis (Disease Ontology:DOID:8929)", "pathway": " (mmu:19247); (R-MMU-1059683); (R-MMU-109704); (R-MMU-110056); (R-MMU-112411); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1295596); (R-MMU-1433557); (R-MMU-180292); (R-MMU-186763); (R-MMU-210990); (R-MMU-210993); (R-MMU-389513); (R-MMU-389948); (R-MMU-432142); (R-MMU-512988); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654700); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-8854691); (R-MMU-8865999); (R-MMU-8934593); (R-MMU-912694); (R-MMU-936964); (R-MMU-9674555); (R-MMU-9927353)", "pathway_count": 38, "publication_count": 56, "publication_id_list": "10.1101/2023.09.13.557529;10026201;10068651;10080542;10327049;10521483;10896938;11432792;11684012;11698646;12181353;12403768;12531430;14610044;14967142;15592455;16684964;16885344;17947660;18034455;18250455;19892989;19948503;20526344;21183079;21952136;23112346;23374343;25153642;25428506;27417137;28135057;28352079;28528544;29644115;30084848;30779550;31219806;33033382;34428180;36210013;36288343;7521735;7522233;7681217;8096088;8622870;8810330;8943348;8959326;9062191;9110989;9393882;9528781;9722576;9867848", "class_list": "", "function": "Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:11698646, PubMed:14967142). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (By similarity). Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to TCR signaling inhibition (PubMed:11698646)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ84;Q64509;Q6PCL5", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0036302 atrioventricular canal development;GO:0048806 genitalia development;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0060125 negative regulation of growth hormone secretion", "synthesized_glycan_count": 0, "hit_score": 6.1, "record_id": "P35235-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62036-1", "uniprot_id": [ { "id": "CP131_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62036", "type": "external" } ], "mass": 120313.0, "length": 1060, "protein_name": "Centrosomal protein of 131 kDa", "gene_name": "Cep131", "organism": "Mouse", "refseq_name": "centrosomal protein of 131 kDa isoform 1", "refseq_ac": [ { "id": "NP_033864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033864", "type": "external" } ], "gene_names_uniprotkb": "Cep131; Az1; Azi1; Azi", "gene_names_refseq": "AZ1; Azi1; Azi; Cep131", "protein_names_uniprotkb": "Centrosomal protein of 131 kDa; 5-azacytidine-induced protein 1; Pre-acrosome localization protein 1", "protein_names_refseq": "5-azacytidine induced gene 1; 5-azacytidine-induced protein 1; centrosomal protein of 131 kDa isoform 1; centrosomal protein of 131 kDa; pre-acrosome localization protein 1", "tax_id": 10090, "disease": "Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:12009); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "17242355;21183079;21750661;24185901;24415959;24550735;26297806;31219806;31358734;34418053;8529672;9070930", "class_list": "", "function": "Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Also acts as a negative regulator of BBSome ciliary trafficking (By similarity). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (PubMed:24415959). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells (By similarity). Involved in centriole duplication (PubMed:26297806). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity). Essential for maintaining proper centriolar satellite integrity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The protein encoding this gene is a centriolar satellite protein that localizes around the basal body via transport along microtubules. Knockdown in mouse fibroblasts results in a reduction in ciliogenesis. Null mutant mice display no discernible ciliary phenotypes and embryonic patterning and adult homeostasis are largely unaffected. Male mice are infertile, however, due to defects in microtubule trafficking in the sperm manchette and flagella. In addition, the protein binds to a complex of proteins associated with Bardet-Biedl syndrome called the BBSome, and depletion of this protein results in an accumulation of the BBSome in cilia. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1AXJ0", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0090316 positive regulation of intracellular protein transport;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62036-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61387-1", "uniprot_id": [ { "id": "CO72L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61387", "type": "external" } ], "mass": 12399.0, "length": 111, "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "Cox7a2l", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 7A2-like, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_033213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033213", "type": "external" } ], "gene_names_uniprotkb": "Cox7a2l; Cox7rp; Scaf1; Silg81", "gene_names_refseq": "COX7AR; COX7RP; Cox7a2l; EB1; SIG-81; SIG81; Scaf1; Silg81", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A2-like, mitochondrial; Cytochrome c oxidase subunit 7A-related protein; Supercomplex assembly factor 1", "protein_names_refseq": "cytochrome c oxidase subunit 7A-related protein, mitochondrial; cytochrome c oxidase subunit 7A2-like, mitochondrial isoform 2; cytochrome c oxidase subunit 7A2-like, mitochondrial; cytochrome c oxidase subunit VIIa polypeptide 2-like; cytochrome c oxidase subunit VIIa-related protein; silica-induced gene 81 protein; supercomplex assembly factor 1; supercomplex assembly factor I", "tax_id": 10090, "disease": "", "pathway": " (mmu:20463); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "21750661;23812712;27775717;31023583;36253618;7868905", "class_list": "", "function": "Non-functional protein (PubMed:23812712, PubMed:27775717). In contrast to the protein found in other strains (AC Q99KD6), cannot induce the assembly of mitochondrial respiratory supercomplexes (PubMed:23812712, PubMed:27775717)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61387-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35218-1", "uniprot_id": [ { "id": "CPSF2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35218", "type": "external" } ], "mass": 88383.0, "length": 782, "protein_name": "Cleavage and polyadenylation specificity factor subunit 2", "gene_name": "Cpsf2", "organism": "Mouse", "refseq_name": "cleavage and polyadenylation specificity factor subunit 2", "refseq_ac": [ { "id": "NP_058552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058552", "type": "external" } ], "gene_names_uniprotkb": "Cpsf2; Cpsf100; Mcpsf", "gene_names_refseq": "100kDa; 2610024B04Rik; Cpsf2; Cpsf; MCPSF; mKIAA1367", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 2; CPSF 100 kDa subunit; Cleavage and polyadenylation specificity factor 100 kDa subunit", "protein_names_refseq": "CPSF 100 kDa subunit; cleavage and polyadenylation specific factor 2, 100kD subunit; cleavage and polyadenylation specificity factor 100 kDa subunit; cleavage and polyadenylation specificity factor subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:51786); (R-MMU-159231); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "16115198;17242355;17622165;19224205;20173027;21183079;22838834;25605945;34428180;39627609", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity)., [UniProtKB]; Cpsf2,Ppil2, and SNAP-25 are the most promising targets for the NSm protein of the virus during an infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35218-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH50-1", "uniprot_id": [ { "id": "ARK2N_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH50", "type": "external" } ], "mass": 26446.0, "length": 245, "protein_name": "Protein ARK2N", "gene_name": "Ark2n", "organism": "Mouse", "refseq_name": "protein ARK2N isoform 1", "refseq_ac": [ { "id": "NP_848785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848785", "type": "external" } ], "gene_names_uniprotkb": "Ark2n", "gene_names_refseq": "8030462N17Rik; Akd2; Ark2n", "protein_names_uniprotkb": "Protein ARK2N; Arkadia (RNF111) N-terminal like PKA signaling regulator 2N; Protein C18orf25 homolog", "protein_names_refseq": "arkadia 2; protein ARK2N isoform 1; protein ARK2N; uncharacterized protein C18orf25 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:212163)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15722956;21183079;34428180;35882232;38480473", "class_list": "", "function": "AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling., [UniProtKB, PubMed]; Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ72;Q8BU43", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0019046 release from viral latency;GO:0006468 protein phosphorylation;GO:0048741 skeletal muscle fiber development;GO:0014823 response to activity;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BH50-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH52-1", "uniprot_id": [ { "id": "CR3L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH52", "type": "external" } ], "mass": 57469.0, "length": 521, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 2", "gene_name": "Creb3l2", "organism": "Mouse", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 2", "refseq_ac": [ { "id": "NP_848776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848776", "type": "external" } ], "gene_names_uniprotkb": "Creb3l2; Bbf2h7", "gene_names_refseq": "BBF2H7; C530025K05Rik; Creb3l2; SCIRR69", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2", "protein_names_refseq": "cAMP-responsive element-binding protein 3-like protein 2; cyclic AMP-responsive element-binding protein 3-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:208647)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17178827;19767744;20495567;22705851;31481663;34428180;38013154", "class_list": "", "function": "Creb3l2 expression and its downstream regulatory network are dependent on Tpit. Creb3l2 acts by direct targeting of translation effector genes in parallel with signaling pathways that otherwise regulate protein synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse beta-cells by co-ordinating insulin biosynthesis with secretory granule formation., [RefSeq, PubMed]; Induction by RAS-mitogen-activated protein kinase or phosphoinositide-3-kinase signaling cascade, which directly activates ATF5 expression and glioma survival, [RefSeq, PubMed]; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (PubMed:19767744). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RRL0;Q8CB61;Q8CBN2", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0035497 cAMP response element binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BH52-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMS4-1", "uniprot_id": [ { "id": "COQ3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMS4", "type": "external" } ], "mass": 40957.0, "length": 370, "protein_name": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial", "gene_name": "Coq3", "organism": "Mouse", "refseq_name": "ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_766275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766275", "type": "external" } ], "gene_names_uniprotkb": "Coq3", "gene_names_refseq": "4732433J24; Coq3", "protein_names_uniprotkb": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial; 2.1.1.-; 2.1.1.114; 2.1.1.64; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone 3-O-methyltransferase; Polyprenyldihydroxybenzoate methyltransferase", "protein_names_refseq": "2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone 3-O-methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; Coenzyme Q (ubiquinone); DHHB methyltransferase; DHHB-MTase; DHHB-MT; coenzyme Q3 homolog, methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; polyprenyldihydroxybenzoate methyltransferase; ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 1; ubiquinone biosynthesis O-methyltransferase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:230027); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21447381;23576753;25428506;36288343", "class_list": "", "function": "Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues, [RefSeq, PubMed]; O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCX5;Q6P918;Q8BM28", "ec_number_list": [ { "id": "1.14.99.60", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.60", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008171 O-methyltransferase activity;GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity;GO:0061542 3-demethylubiquinol 3-O-methyltransferase activity;GO:0120537 3-demethylubiquinone 3-O-methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0006071 glycerol metabolic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BMS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIT0-1", "uniprot_id": [ { "id": "CRH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIT0", "type": "external" } ], "mass": 20778.0, "length": 187, "protein_name": "Corticotropin-releasing hormone", "gene_name": "Crh", "organism": "Mouse", "refseq_name": "corticoliberin preproprotein", "refseq_ac": [ { "id": "NP_991338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991338", "type": "external" } ], "gene_names_uniprotkb": "Crh; Gm1347", "gene_names_refseq": "CRF; Crh; Gm1347", "protein_names_uniprotkb": "Corticotropin-releasing hormone; CRF; Corticoliberin; Corticotropin-releasing factor", "protein_names_refseq": "corticoliberin preproprotein; corticoliberin; corticotropin releasing factor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); panic disorder (Disease Ontology:DOID:594); retinal degeneration (Disease Ontology:DOID:8466); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:12918); (R-MMU-373080); (R-MMU-418555)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16682628;19912808;22992525;23470617;27641503;37669667;7830793", "class_list": "", "function": "Hormone that plays a central role in whole body adaptation to stress (PubMed:16682628, PubMed:22992525, PubMed:23470617, PubMed:7830793). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (PubMed:22992525). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:22992525). Also involved in social behavior by triggering a signaling in the prefrontal cortex that favor social interactions with novel conspecifics over familiar ones (PubMed:37669667). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor (By similarity). Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14AA2", "ec_number_list": [], "go_molecular_function": "GO:0017045 corticotropin-releasing hormone activity;GO:0051430 corticotropin-releasing hormone receptor 1 binding;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0098793 presynapse", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0098828 modulation of inhibitory postsynaptic potential;GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CIT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29319-1", "uniprot_id": [ { "id": "EPHA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P29319", "type": "external" } ], "mass": 109955.0, "length": 983, "protein_name": "Ephrin type-A receptor 3", "gene_name": "Epha3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Epha3; Etk1; Mek4; Tyro4", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-A receptor 3; 2.7.10.1; EK4; EPH-like kinase 4; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; mEK4", "protein_names_refseq": "", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11870224;14585969;1657122;17046737;17947660;18403711;19505147;20960543;21750661;27446912;35820727", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (PubMed:17046737, PubMed:19505147, PubMed:20960543). Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration (PubMed:19505147). Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:17046737, PubMed:20960543). Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (PubMed:18403711)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0045806 negative regulation of endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P29319-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHK9-1", "uniprot_id": [ { "id": "ERC6L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHK9", "type": "external" } ], "mass": 138854.0, "length": 1240, "protein_name": "DNA excision repair protein ERCC-6-like", "gene_name": "Ercc6l", "organism": "Mouse", "refseq_name": "DNA excision repair protein ERCC-6-like", "refseq_ac": [ { "id": "NP_666347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666347", "type": "external" } ], "gene_names_uniprotkb": "Ercc6l", "gene_names_refseq": "D330021P09Rik; Ercc6l", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like; 3.6.4.12; ATP-dependent helicase ERCC6-like", "protein_names_refseq": "ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; SNF2/RAD54 family protein; excision repair cross-complementing rodent repair deficiency complementation group 6 - like", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:236930); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "15917148;17242355;21183079;26495903;28528544;30232008;31219806;34428180;39627609", "class_list": "", "function": "DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)., [UniProtKB, UniProtKB]; Ercc6l is essential to preserve chromosomal integrity during embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGN1;Q8BRC9;Q8CE49", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0015616 DNA translocase activity", "go_cellular_component": "GO:0000776 kinetochore", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BHK9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JZ7-1", "uniprot_id": [ { "id": "ERRFI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JZ7", "type": "external" } ], "mass": 50075.0, "length": 461, "protein_name": "ERBB receptor feedback inhibitor 1", "gene_name": "Errfi1", "organism": "Mouse", "refseq_name": "ERBB receptor feedback inhibitor 1", "refseq_ac": [ { "id": "NP_598514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598514", "type": "external" } ], "gene_names_uniprotkb": "Errfi1; Mig6", "gene_names_refseq": "1300002F13Rik; Errfi1; Mig-6; Mig6; RALT", "protein_names_uniprotkb": "ERBB receptor feedback inhibitor 1; MIG-6; Mitogen-inducible gene 6 protein homolog", "protein_names_refseq": "ERBB receptor feedback inhibitor 1; mitogen-inducible gene 6 protein homolog", "tax_id": 10090, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); endometrial cancer (Disease Ontology:DOID:1380); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:74155)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16007071;16087873;16648858;17242355;19439667;19683494;19710174;20018910;21183079;31219806;34358969;35232969;38862918", "class_list": "", "function": "ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of Mig-6 leads to early onset of joint disease, [RefSeq, PubMed]; Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue., [RefSeq, PubMed]; Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; RALT behaves as a suppressor of EGFR signalling in mouse skin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0001889 liver development;GO:0006468 protein phosphorylation;GO:0006629 lipid metabolic process;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99JZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26048-1", "uniprot_id": [ { "id": "GBRA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P26048", "type": "external" } ], "mass": 51139.0, "length": 451, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-2", "gene_name": "Gabra2", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032092", "type": "external" } ], "gene_names_uniprotkb": "Gabra2; Gabra-2", "gene_names_refseq": "C630048P16Rik; Gabra-2; Gabra2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor subunit alpha-2; GABAAR subunit alpha-2", "protein_names_refseq": "GABAAR subunit alpha-2; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2; gamma-aminobutyric acid receptor subunit alpha-2 isoform 1 precursor; gamma-aminobutyric acid receptor subunit alpha-2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); developmental and epileptic encephalopathy 78 (Disease Ontology:DOID:0112214); autistic disorder (Disease Ontology:DOID:12849); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:14395); (R-MMU-977443)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11528422;1356407;21750661;27129275;28978485;30899004;31601770;33300544", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0008503 benzodiazepine receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P26048-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61835-1", "uniprot_id": [ { "id": "FXYD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61835", "type": "external" } ], "mass": 9526.0, "length": 88, "protein_name": "FXYD domain-containing ion transport regulator 3", "gene_name": "Fxyd3", "organism": "Mouse", "refseq_name": "FXYD domain-containing ion transport regulator 3 precursor", "refseq_ac": [ { "id": "NP_032583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032583", "type": "external" } ], "gene_names_uniprotkb": "Fxyd3; Mat8; Plml", "gene_names_refseq": "Fxyd3; Mat8", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 3; Chloride conductance inducer protein Mat-8; Mammary tumor 8 kDa protein; Phospholemman-like; Sodium/potassium-transporting ATPase subunit FXYD3", "protein_names_refseq": "FXYD domain-containing ion transport regulator 3 precursor; chloride conductance inducer protein Mat-8; mammary tumor 8 kDa protein; sodium/potassium-transporting ATPase subunit FXYD3", "tax_id": 10090, "disease": "", "pathway": " (mmu:17178); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14694902;15743908;21750661;25058609;7836447;7970700", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15743908). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Because gluco-incretin secretion depends on feeding the epigenetic regulation of Fxyd3 expression may link nutrition in early life to establishment of adult beta-cell glucose competence. Erratum:[PLoS One. 2014;9(12):e116451. Nagaray, Vini [corrected to Nagaraj, Vini]] Publication Status: Online-Only, [RefSeq, PubMed]; Fxyd3 and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression, [RefSeq, PubMed]; Regulator of Na,K-ATPase, [RefSeq, PubMed]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The encoded protein is a transmembrane protein that functions as a specific regulator of Na,K-ATPase. [provided by RefSeq, Aug 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050790 regulation of catalytic activity;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61835-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01101-1", "uniprot_id": [ { "id": "FOS_MOUSE", "url": "https://www.uniprot.org/uniprot/P01101", "type": "external" } ], "mass": 40838.0, "length": 380, "protein_name": "Protein c-Fos", "gene_name": "Fos", "organism": "Mouse", "refseq_name": "protein c-Fos", "refseq_ac": [ { "id": "NP_034364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034364", "type": "external" } ], "gene_names_uniprotkb": "Fos", "gene_names_refseq": "D12Rfj1; Fos; c-fos; cFos", "protein_names_uniprotkb": "Protein c-Fos; Cellular oncogene fos; FBJ osteosarcoma oncogene; Transcription factor AP-1 subunit c-Fos", "protein_names_refseq": "FBJ osteosarcoma oncogene; cellular oncogene fos; protein c-Fos; proto-oncogene c-Fos; proto-oncogene protein c-fos; transcription factor AP-1 subunit c-Fos", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); sleeping sickness (Disease Ontology:DOID:10112); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); hypospadias (Disease Ontology:DOID:10892); functional diarrhea (Disease Ontology:DOID:11371); Pick's disease (Disease Ontology:DOID:11870); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); rectal benign neoplasm (Disease Ontology:DOID:1984); Wernicke encephalopathy (Disease Ontology:DOID:2384); morphine dependence (Disease Ontology:DOID:2560); glomerulonephritis (Disease Ontology:DOID:2921); temporal lobe epilepsy (Disease Ontology:DOID:3328); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); migraine (Disease Ontology:DOID:6364); amphetamine abuse (Disease Ontology:DOID:670); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); degenerative disc disease (Disease Ontology:DOID:90); acute myocardial infarction (Disease Ontology:DOID:9408); irritable bowel syndrome (Disease Ontology:DOID:9778); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:14281); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450341)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "11397794;12134156;12629509;12972619;15719069;17909266;21119595;21998197;22105363;22169952;26866564;29272704;2991903;30515991;31219806;38861834;6301687;7588633", "class_list": "", "function": "Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0003407 neural retina development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P01101-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70339-1", "uniprot_id": [ { "id": "FRAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70339", "type": "external" } ], "mass": 28875.0, "length": 274, "protein_name": "Proto-oncogene FRAT1", "gene_name": "Frat1", "organism": "Mouse", "refseq_name": "proto-oncogene FRAT1", "refseq_ac": [ { "id": "NP_032069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032069", "type": "external" } ], "gene_names_uniprotkb": "Frat1", "gene_names_refseq": "Frat1", "protein_names_uniprotkb": "Proto-oncogene FRAT1; FRAT-1; Frequently rearranged in advanced T-cell lymphomas 1", "protein_names_refseq": "frequently rearranged in advanced T-cell lymphomas 1; proto-oncogene FRAT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14296); (R-MMU-196299); (R-MMU-4641262)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15073180;15699046;19802005;21183079;22064483;9034327", "class_list": "", "function": "Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling., [RefSeq, PubMed]; Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3., [RefSeq, PubMed]; Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus., [RefSeq, PubMed]; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0060070 canonical Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006611 protein export from nucleus;GO:0046825 regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70339-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61345-1", "uniprot_id": [ { "id": "FOXD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61345", "type": "external" } ], "mass": 45371.0, "length": 456, "protein_name": "Forkhead box protein D1", "gene_name": "Foxd1", "organism": "Mouse", "refseq_name": "forkhead box protein D1", "refseq_ac": [ { "id": "NP_032268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032268", "type": "external" } ], "gene_names_uniprotkb": "Foxd1; Fkhl8; Freac4; Hfhbf2", "gene_names_refseq": "BF-2; FREAC4; Foxd1; Hfh10; Hfhbf2", "protein_names_uniprotkb": "Forkhead box protein D1; BF-2; Brain factor 2; FREAC-4; Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; HFH-BF-2", "protein_names_refseq": "FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4); FREAC-4; HFH-BF-2; HNF-3/forkhead homolog, brain factor 2; brain factor 2; forkhead box protein D1; forkhead-related protein FKHL8; forkhead-related transcription factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:15229)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15509772;15634693;20485683;22872234;34428180;7815060;9811586", "class_list": "", "function": "Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (PubMed:15509772, PubMed:15634693, PubMed:9811586). Involved in transcriptional activation of PGF and C3 genes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQW8", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0032275 luteinizing hormone secretion;GO:0072268 pattern specification involved in metanephros development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61345-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZL1-1", "uniprot_id": [ { "id": "FGD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZL1", "type": "external" } ], "mass": 155169.0, "length": 1399, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 6", "gene_name": "Fgd6", "organism": "Mouse", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 6", "refseq_ac": [ { "id": "NP_444302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444302", "type": "external" } ], "gene_names_uniprotkb": "Fgd6; Kiaa1362", "gene_names_refseq": "Etohd4; Fgd6; ZFYVE24", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 6", "protein_names_refseq": "FYVE, RhoGEF and PH domain-containing protein 6; ethanol decreased 4", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (mmu:13998)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19144319;21183079;22872234;24821726;25428506", "class_list": "", "function": "FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts., [RefSeq, PubMed]; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8W5;Q8K3B0;Q9D3Y7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q69ZL1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGT1-1", "uniprot_id": [ { "id": "FLRT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGT1", "type": "external" } ], "mass": 72879.0, "length": 649, "protein_name": "Leucine-rich repeat transmembrane protein FLRT3", "gene_name": "Flrt3", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane protein FLRT3 precursor", "refseq_ac": [ { "id": "NP_001165631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165631", "type": "external" } ], "gene_names_uniprotkb": "Flrt3; Kiaa1469", "gene_names_refseq": "5530600M07Rik; C430047I10Rik; Flrt3; mKIAA1469", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT3; Fibronectin leucine rich transmembrane protein 3", "protein_names_refseq": "leucine-rich repeat transmembrane protein FLRT3 precursor; leucine-rich repeat transmembrane protein FLRT3", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 21 with or without anosmia (Disease Ontology:DOID:0090093)", "pathway": " (mmu:71436); (R-MMU-5654687)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;16872596;18448090;19056886;19492039;21350012;21673655;22405201;24560577;24739570;25374360;25428506;26235031;30792275;33300544;34428180;35820727", "class_list": "", "function": "Data demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo., [RefSeq, PubMed]; FLRT3 has an expression pattern during somite development, [RefSeq, PubMed]; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (PubMed:19056886, PubMed:30792275, PubMed:25374360). Plays a role in the spatial organization of brain neurons (PubMed:25374360). Plays a role in vascular development in the retina (PubMed:25374360). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:30792275, PubMed:25374360). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25374360). Promotes neurite outgrowth (in vitro) (By similarity). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length (By similarity). Plays a role in the regulation of the density of glutamaergic synapses (PubMed:22405201). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning (PubMed:19056886). Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development (PubMed:18448090). Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (PubMed:19056886)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPQ1", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0045499 chemorepellent activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0032584 growth cone membrane;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0031175 neuron projection development;GO:0098609 cell-cell adhesion;GO:0007416 synapse assembly;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8BGT1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPB7-1", "uniprot_id": [ { "id": "GPR88_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPB7", "type": "external" } ], "mass": 40240.0, "length": 384, "protein_name": "G protein-coupled receptor 88", "gene_name": "Gpr88", "organism": "Mouse", "refseq_name": "G protein-coupled receptor 88", "refseq_ac": [ { "id": "NP_071872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071872", "type": "external" } ], "gene_names_uniprotkb": "Gpr88; Strg", "gene_names_refseq": "Gpr88; Strg", "protein_names_uniprotkb": "G protein-coupled receptor 88; Striatum-specific G protein-coupled receptor", "protein_names_refseq": "G protein-coupled receptor 88; probable G-protein coupled receptor 88; striatum-specific G-protein coupled receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:64378)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11056049;19796684;21750661;23064379;25428506;26188600;30084848;33078498;34247243;34428180", "class_list": "", "function": "Impaired working memory, cognitive flexibility and reward processing in mice genetically lacking Gpr88: Evidence for a key role for Gpr88 in multiple cortico-striatal-thalamic circuits., [RefSeq, PubMed]; Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (PubMed:26188600). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (By similarity). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (By similarity). In on-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex., [RefSeq, PubMed]; The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders., [RefSeq, PubMed]; This study demonistrated that lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0004941 beta2-adrenergic receptor activity;GO:0003774 cytoskeletal motor activity;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0019228 neuronal action potential;GO:0050885 neuromuscular process controlling balance;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EPB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIM5-1", "uniprot_id": [ { "id": "GPR84_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIM5", "type": "external" } ], "mass": 43717.0, "length": 396, "protein_name": "G protein-coupled receptor 84", "gene_name": "Gpr84", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 84", "refseq_ac": [ { "id": "NP_109645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109645", "type": "external" } ], "gene_names_uniprotkb": "Gpr84", "gene_names_refseq": "EX33; Gpr84", "protein_names_uniprotkb": "G protein-coupled receptor 84", "protein_names_refseq": "G-protein coupled receptor 84; orphan G protein-coupled receptor 84", "tax_id": 10090, "disease": "", "pathway": " (mmu:80910); (R-MMU-418555); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11273702;15993493;16966319;17390309;19144319;21750661;25428506;29973940;34912006;37016043;38349405;38471516;38814782", "class_list": "", "function": "G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver., [RefSeq, PubMed]; G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (By similarity). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (by sim). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (PubMed:34912006). Also plays an important role in inflammation by modulating neutrophil functions (PubMed:37016043). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (PubMed:37016043). To regulate ROS production, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:29973940)., [UniProtKB, PubMed, UniProtKB]; G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds., [RefSeq, PubMed]; In mice suffering from endotoxemia, microglia express GPR84 in a strong and sustained manner, [RefSeq, PubMed]; Primary stimulation of T cells with anti-CD3 resulted in increased interleukin-4 but not interleukin-2 or interferon -gamma production in GPR84(-/-) mice compared to wild-type mice, [RefSeq, PubMed]; Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99MX9", "ec_number_list": [], "go_molecular_function": "GO:0001604 urotensin II receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CIM5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921L8-1", "uniprot_id": [ { "id": "GLT11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921L8", "type": "external" } ], "mass": 69201.0, "length": 608, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 11", "gene_name": "Galnt11", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 11", "refseq_ac": [ { "id": "NP_659157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659157", "type": "external" } ], "gene_names_uniprotkb": "Galnt11", "gene_names_refseq": "A430075I06Rik; E430002F06Rik; Galnt11", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 11; 2.4.1.41; GalNAc-T11; Polypeptide GalNAc transferase 11; Protein-UDP acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; pp-GaNTase 11", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11; galNAc-T11; polypeptide GalNAc transferase 11; polypeptide N-acetylgalactosaminyltransferase 11; pp-GaNTase 11; protein-UDP acetylgalactosaminyltransferase 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:231050); (R-MMU-913709)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11925450;12651884;15486088;21183079;21750661;24226769;31740596;32917924;38484798", "class_list": "glycogene;glycosyltransferase", "function": "Genetic variation regulates opioid-induced respiratory depression in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Homology models of several ppGaNTase isoforms predict dramatically different surface chemistries consistent with isoform-selective acceptor substrate recognition, [RefSeq, PubMed]; Loss of the glycosyltransferase Galnt11 affects vitamin D homeostasis and bone composition., [RefSeq, PubMed]; Megalin in Galnt11-deficient mice displays reduced ligand binding and undergoes age-related loss within the kidney., [RefSeq, PubMed]; Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) (By similarity)., [UniProtKB]; Real-time polymerase chain reaction using the Taqman method to determine the expression of ppGaNTase isoforms in mouse tissues. In contrast to the general pattern, testis, sublingual gland, and colon exhibited distinctive profiles of isoform expression, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT83;Q8BU26;Q8K032", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005112 Notch binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0061314 Notch signaling involved in heart development;GO:0007220 Notch receptor processing;GO:0006493 protein O-linked glycosylation;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 7434, "hit_score": 1.3, "record_id": "Q921L8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03995-1", "uniprot_id": [ { "id": "GFAP_MOUSE", "url": "https://www.uniprot.org/uniprot/P03995", "type": "external" } ], "mass": 49900.0, "length": 430, "protein_name": "Glial fibrillary acidic protein", "gene_name": "Gfap", "organism": "Mouse", "refseq_name": "glial fibrillary acidic protein isoform 1", "refseq_ac": [ { "id": "NP_001124492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124492", "type": "external" } ], "gene_names_uniprotkb": "Gfap", "gene_names_refseq": "Gfap", "protein_names_uniprotkb": "Glial fibrillary acidic protein; GFAP", "protein_names_refseq": "glial fibrillary acidic protein isoform 1; intermediate filament protein", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); alcohol use disorder (Disease Ontology:DOID:1574); Alexander disease (Disease Ontology:DOID:4252); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:14580)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11471062;12058025;12837269;16452087;17356066;18198358;2163003;24129315;2994002;33300544;3866511;40684658;6585825;7983160", "class_list": "", "function": "GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1E2H7;A2AH87;B2RTI7;Q09J71;Q3USS4;Q496R4;Q496S3;Q7TQ30;Q80VX6;Q925K2;Q925K3", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0043209 myelin sheath;GO:0097449 astrocyte projection", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0060252 positive regulation of glial cell proliferation;GO:0006886 intracellular protein transport;GO:0030198 extracellular matrix organization;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P03995-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X632-1", "uniprot_id": [ { "id": "GPR75_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6X632", "type": "external" } ], "mass": 59531.0, "length": 540, "protein_name": "Probable G protein-coupled receptor 75", "gene_name": "Gpr75", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 75", "refseq_ac": [ { "id": "NP_780699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780699", "type": "external" } ], "gene_names_uniprotkb": "Gpr75", "gene_names_refseq": "Gpr75", "protein_names_uniprotkb": "Probable G protein-coupled receptor 75", "protein_names_refseq": "probable G-protein coupled receptor 75", "tax_id": 10090, "disease": "", "pathway": " (mmu:237716)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17001303;23979485;36854900;36978267;37840219;38653246;39137039", "class_list": "", "function": "Although CCL5 is implicated in the pathogenesis of diabetes through activation of CCRs, it has beneficial effects on beta cells through GPR75 activation., [RefSeq, PubMed]; G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor., [UniProtKB, PubMed, PubMed]; GPR75 is a ciliary protein expressed in the brain and plays an important role in regulating food intake. Publication Status: Online-Only, [RefSeq, PubMed]; Gpr75 knockout mice display age-dependent cone photoreceptor cell loss., [RefSeq, PubMed]; Gpr75-deficient mice are protected from high-fat diet-induced obesity., [RefSeq, PubMed]; Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation., [RefSeq, PubMed]; Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3URC1;Q8BXP3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0070098 chemokine-mediated signaling pathway;GO:0070371 ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6X632-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C206-1", "uniprot_id": [ { "id": "GP157_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C206", "type": "external" } ], "mass": 36344.0, "length": 330, "protein_name": "G protein-coupled receptor 157", "gene_name": "Gpr157", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 157", "refseq_ac": [ { "id": "NP_796340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796340", "type": "external" } ], "gene_names_uniprotkb": "Gpr157", "gene_names_refseq": "F730108M23Rik; Gpr157", "protein_names_uniprotkb": "G protein-coupled receptor 157", "protein_names_refseq": "G-protein coupled receptor 157; novel 7 transmembrane receptor (Secretin family) domain containing protein; probable G-protein coupled receptor 157", "tax_id": 10090, "disease": "", "pathway": " (mmu:269604)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27142930", "class_list": "", "function": "Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs) (PubMed:27142930). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger (PubMed:27142930)., [UniProtKB, PubMed]; Thus, GPR157-Gq protein signaling at the primary cilia of radial glial progenitors is activated by the cerebrospinal fluid and contributes to neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C224", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0048512 circadian behavior;GO:0060019 radial glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C206-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07133-1", "uniprot_id": [ { "id": "H1T_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07133", "type": "external" } ], "mass": 21540.0, "length": 208, "protein_name": "Histone H1t", "gene_name": "H1-6; H1f6", "organism": "Mouse", "refseq_name": "histone H1t", "refseq_ac": [ { "id": "NP_034507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034507", "type": "external" } ], "gene_names_uniprotkb": "H1-6; H1f6; H1f6; H1ft; H1t; Hist1h1t", "gene_names_refseq": "H1-6; H1.6; H1f6; H1ft; H1t; Hist1h1t", "protein_names_uniprotkb": "Histone H1t; Testicular H1 histone", "protein_names_refseq": "H1 histone family, member T (testis-specific); histone 1, H1t; histone H1t; histone cluster 1, H1t; testicular H1 histone", "tax_id": 10090, "disease": "", "pathway": " (mmu:107970)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12408966;18698803;19043117;21750661;25605945;26495903;32152506;35820727;8241275", "class_list": "", "function": "Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element [provided by RefSeq, Aug 2015]., [RefSeq]; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEA3;Q8CGP8", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q07133-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01942-1", "uniprot_id": [ { "id": "HBA_MOUSE", "url": "https://www.uniprot.org/uniprot/P01942", "type": "external" } ], "mass": 15085.0, "length": 142, "protein_name": "Hemoglobin subunit alpha", "gene_name": "Hba", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hba; Hba-a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "hemoglobin H disease (Disease Ontology:DOID:0110031); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 7 (Disease Ontology:DOID:0111631); Alzheimer's disease (Disease Ontology:DOID:10652); alpha thalassemia (Disease Ontology:DOID:1099)", "pathway": " (R-MMU-1237044); (R-MMU-1247673); (R-MMU-2168880); (R-MMU-9707564); (R-MMU-9707616)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "21183079;21913724;22645316;23806337;25428506;26495903;26740625;277329;27802388;282635;28935714;31219806;32152506;34428180;34887587;36210013;36288343;36583994;37453647;37828378;39627609;519760;5340470;5345070;7092800", "class_list": "", "function": "Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling., [UniProtKB, UniProtKB]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0043209 myelin sheath;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0035634 response to stilbenoid;GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P01942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61586-1", "uniprot_id": [ { "id": "GPAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61586", "type": "external" } ], "mass": 93705.0, "length": 827, "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial", "gene_name": "Gpam", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate acyltransferase 1, mitochondrial", "refseq_ac": [ { "id": "NP_032175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032175", "type": "external" } ], "gene_names_uniprotkb": "Gpam; Gpat1", "gene_names_refseq": "GPAT-1; GPAT1; GPAT; Gpam; P90", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 1, mitochondrial; 2.3.1.15; GPAT-1; P90", "protein_names_refseq": "glycerol-3-phosphate acyltransferase 1, mitochondrial", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nephrotic syndrome (Disease Ontology:DOID:1184); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14732); (R-MMU-1483166); (R-MMU-75109)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "16682971;17208939;1721057;17242355;18630941;21183079;21750661;22872234;23576753;30084848;31219806;31599954;34203471;34428180;37453647;37844795;38354952", "class_list": "", "function": "GPAT1 Activity and Abundant Palmitic Acid Impair Insulin Suppression of Hepatic Glucose Production in Primary Mouse Hepatocytes., [RefSeq, PubMed]; GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner., [RefSeq, PubMed]; Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (By similarity). Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid (By similarity). Has a narrow hydrophobic binding cleft that selects for a linear acyl chain (By similarity). Catalytic activity is higher for substrates with a 16-carbon acyl chain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCT2", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006641 triglyceride metabolic process;GO:0006654 phosphatidic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q61586-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X51-1", "uniprot_id": [ { "id": "GORS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X51", "type": "external" } ], "mass": 46882.0, "length": 446, "protein_name": "Golgi reassembly-stacking protein 1", "gene_name": "Gorasp1", "organism": "Mouse", "refseq_name": "Golgi reassembly-stacking protein 1", "refseq_ac": [ { "id": "NP_083252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083252", "type": "external" } ], "gene_names_uniprotkb": "Gorasp1", "gene_names_refseq": "5430411C10Rik; GOLPH5; GRASP65; Gorasp1; P65", "protein_names_uniprotkb": "Golgi reassembly-stacking protein 1; GRASP65; Golgi peripheral membrane protein p65; Golgi reassembly-stacking protein of 65 kDa", "protein_names_refseq": "Golgi reassembly-stacking protein 1; golgi peripheral membrane protein p65; golgi reassembly-stacking protein of 65 kDa", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:74498); (R-MMU-162658); (R-MMU-204005); (R-MMU-6807878)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "17242355;21183079;25428506;25605945;30084848;32573693", "class_list": "", "function": "Key structural protein of the Golgi apparatus (PubMed:32573693). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The function of GORASPs in Golgi apparatus organization in vivo. Erratum:[J Cell Biol. 2020 Sep 7;219(9):jcb.20200419106242020c. doi: 10.1083/jcb.20200419106242020c. PMID: 32589188], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3L9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0050774 negative regulation of dendrite morphogenesis;GO:0006487 protein N-linked glycosylation;GO:0090161 Golgi ribbon formation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91X51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15864-1", "uniprot_id": [ { "id": "H12_MOUSE", "url": "https://www.uniprot.org/uniprot/P15864", "type": "external" } ], "mass": 21267.0, "length": 212, "protein_name": "Histone H1.2", "gene_name": "H1-2", "organism": "Mouse", "refseq_name": "histone H1.2", "refseq_ac": [ { "id": "NP_056601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056601", "type": "external" } ], "gene_names_uniprotkb": "H1-2; H1f2; Hist1h1c", "gene_names_refseq": "0610008C09Rik; H1-2; H1.2; H1c; H1f2; H1var1; His1a; Hist1h1c", "protein_names_uniprotkb": "Histone H1.2; H1 VAR.1; H1c", "protein_names_refseq": "H1 VAR.1; H1 histone family, member 2; histone 1, H1c; histone H1.2; histone H1; histone cluster 1, H1c", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:50708)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "12408966;12808097;16377562;21540332;21925322;22645316;23806337;24463520;24681537;24788674;26495903;2780558;2824517;28392790;31209405;31219806;33300544;33725478;34428180;35294987;35984892;36288343;39627609;39927985;8639656;9655912", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:12808097, PubMed:16377562). Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibers (PubMed:12808097, PubMed:16377562). Histone H1-2 also acts as a histone reader: specifically recognizes and binds histone H3 trimethylated at 'lys-27' (H3K27me3) (By similarity). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication (By similarity). Together with histone H1-3, histone H1-2 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-2 has a high affinity for exons and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (By similarity). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling., [RefSeq, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0061628 histone H3K27me3 reader activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000791 euchromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0140718 facultative heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P15864-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64475-1", "uniprot_id": [ { "id": "H2B1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64475", "type": "external" } ], "mass": 13952.0, "length": 126, "protein_name": "Histone H2B type 1-B", "gene_name": "H2bc3", "organism": "Mouse", "refseq_name": "histone H2B type 1-B", "refseq_ac": [ { "id": "NP_783595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783595", "type": "external" } ], "gene_names_uniprotkb": "H2bc3; Hist1h2bb", "gene_names_refseq": "H2b-143; H2bc3; Hist1h2bb", "protein_names_uniprotkb": "Histone H2B type 1-B; H2B-clustered histone 3; h2B-143", "protein_names_refseq": "histone 1, H2bb; histone H2B type 1-B; histone cluster 1, H2bb", "tax_id": 10090, "disease": "", "pathway": " (mmu:319178); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 18, "publication_id_list": "12408966;15197225;16039583;19224205;20173027;20647423;21913724;21925322;22389435;23806337;24681537;27105115;30154464;31645732;32822587;33725478;39627609;8611618", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14AF8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q64475-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZP2-1", "uniprot_id": [ { "id": "GPBL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZP2", "type": "external" } ], "mass": 51966.0, "length": 473, "protein_name": "Vasculin-like protein 1", "gene_name": "Gpbp1l1", "organism": "Mouse", "refseq_name": "vasculin-like protein 1", "refseq_ac": [ { "id": "NP_084144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084144", "type": "external" } ], "gene_names_uniprotkb": "Gpbp1l1", "gene_names_refseq": "5330440M15Rik; Gpbp1l1", "protein_names_uniprotkb": "Vasculin-like protein 1; GC-rich promoter-binding protein 1-like 1", "protein_names_refseq": "vasculin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77110)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19144319;21183079;35820727", "class_list": "", "function": "Possible transcription factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHW7;Q8BI03;Q8K2H8;Q9CTV6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NZP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERP3-1", "uniprot_id": [ { "id": "TRI54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERP3", "type": "external" } ], "mass": 41131.0, "length": 366, "protein_name": "Tripartite motif-containing protein 54", "gene_name": "Trim54", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 54", "refseq_ac": [ { "id": "NP_067422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067422", "type": "external" } ], "gene_names_uniprotkb": "Trim54; Murf; Rnf30", "gene_names_refseq": "4930486E09Rik; 4930566I02Rik; MURF-3; MURF; MuRF3; Rnf30; Trim54", "protein_names_uniprotkb": "Tripartite motif-containing protein 54; MuRF-3; MuRF3; MuRF; Muscle-specific RING finger protein 3; Muscle-specific RING finger protein; RING finger protein 30", "protein_names_refseq": "muscle-specific RING finger protein 3; muscle-specific RING-finger protein; ring finger protein 30; tripartite motif-containing protein 54", "tax_id": 10090, "disease": "", "pathway": " (mmu:58522)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10953002;17360532;17786241;21750661;26215257;31599954;38082493", "class_list": "", "function": "Findings suggest that MuRF3 helps stabilize cardiac PPARalpha and PPARgamma1 in vivo to support resistance to the development of diabetic cardiomyopathy. MuRF3 also plays an unexpected role in regulating fat storage despite being found only in striated muscle. Publication Status: Online-Only, [RefSeq, PubMed]; May bind and stabilize microtubules during myotubes formation., [UniProtKB, PubMed, UniProtKB, UniProtKB]; MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3, [RefSeq, PubMed]; Muscle RING finger 1 and muscle RING finger 3 as key E3 ubiquitin ligases for the ubiquitin proteasome system-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies, [RefSeq, PubMed]; Post-transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005875 microtubule associated complex;GO:0030018 Z disc", "go_biological_process": "GO:0030154 cell differentiation;GO:0045087 innate immune response;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ERP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14142-1", "uniprot_id": [ { "id": "GLUT4_MOUSE", "url": "https://www.uniprot.org/uniprot/P14142", "type": "external" } ], "mass": 54755.0, "length": 509, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 4", "gene_name": "Slc2a4", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 4 isoform 1", "refseq_ac": [ { "id": "NP_033230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033230", "type": "external" } ], "gene_names_uniprotkb": "Slc2a4; Glut4", "gene_names_refseq": "GT2; Glut-4; Glut4; Slc2a4; twgy", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; GT2; Glucose transporter type 4, insulin-responsive", "protein_names_refseq": "glucose transporter type 4, insulin-responsive; solute carrier family 2, facilitated glucose transporter member 4 isoform 1", "tax_id": 10090, "disease": "coronary artery disease (Disease Ontology:DOID:3393); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20528); (R-MMU-189200)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10952468;12110528;12637568;19349973;20173027;21183079;21750661;21907143;25586176;26240143;2654938;26629404;27354378;27739494;36288343;39182843", "class_list": "glycogene", "function": "Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake., [UniProtKB, UniProtKB]; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:26240143, PubMed:26629404). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:26240143, PubMed:26629404). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:26240143, PubMed:26629404)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Picalm, a novel regulator of GLUT4-trafficking in adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPK6;Q9JJN9", "ec_number_list": [], "go_molecular_function": "GO:0005360 insulin-responsive D-glucose:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015304 D-glucose uniporter activity;GO:0022857 transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0007611 learning or memory;GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P14142-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21279-1", "uniprot_id": [ { "id": "GNAQ_MOUSE", "url": "https://www.uniprot.org/uniprot/P21279", "type": "external" } ], "mass": 42158.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein G(q) subunit alpha", "gene_name": "Gnaq", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(q) subunit alpha", "refseq_ac": [ { "id": "NP_032165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032165", "type": "external" } ], "gene_names_uniprotkb": "Gnaq", "gene_names_refseq": "1110005L02Rik; 6230401I02Rik; Dsk10; Dsk1; Galphaq; Gnaq; GqI; Gq", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(q) subunit alpha; 3.6.5.-; Guanine nucleotide-binding protein alpha-q", "protein_names_refseq": "guanine nucleotide-binding protein G(q) subunit alpha", "tax_id": 10090, "disease": "familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); dilated cardiomyopathy (Disease Ontology:DOID:12930); McCune Albright syndrome (Disease Ontology:DOID:1858); lung non-small cell carcinoma (Disease Ontology:DOID:3908); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14682); (R-MMU-112043); (R-MMU-202040); (R-MMU-399997); (R-MMU-416476); (R-MMU-418592); (R-MMU-428930); (R-MMU-434316); (R-MMU-456926); (R-MMU-6814122); (R-MMU-9856530); (R-MMU-9860927)", "pathway_count": 12, "publication_count": 16, "publication_id_list": "17938235;18802028;19001095;20624888;20966218;2123549;23022564;23994616;32152506;33300544;34428180;39225978;8227063;9296496;9391157;9687499", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:20966218, PubMed:9687499). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:20966218). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:20966218). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:20966218). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:20966218). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218). Required for platelet activation (PubMed:9296496). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (PubMed:20624888). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (PubMed:17938235). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (PubMed:9687499)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFF5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" } ], "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0045634 regulation of melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P21279-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43276-1", "uniprot_id": [ { "id": "H15_MOUSE", "url": "https://www.uniprot.org/uniprot/P43276", "type": "external" } ], "mass": 22576.0, "length": 223, "protein_name": "Histone H1.5", "gene_name": "H1-5", "organism": "Mouse", "refseq_name": "histone H1.5", "refseq_ac": [ { "id": "NP_064418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064418", "type": "external" } ], "gene_names_uniprotkb": "H1-5; H1f5; Hist1h1b", "gene_names_refseq": "H1-5; H1.5; H1B; H1f5; H1s-3; Hist1h1b", "protein_names_uniprotkb": "Histone H1.5; H1 VAR.5; H1b", "protein_names_refseq": "H1 VAR.5; H1 histone family, member 5; histone 1, H1b; histone 1, family 5; histone H1.5; histone cluster 1, H1b", "tax_id": 10090, "disease": "", "pathway": " (mmu:56702); (R-MMU-140342); (R-MMU-2559584)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "12408966;16600910;17242355;21183079;23806337;24463520;25605945;26495903;28539972;31219806;33300544;33725478;34428180;35820727;35984892;36288343;39627609;39927985;8589518;8858344", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRM8", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P43276-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV38-1", "uniprot_id": [ { "id": "GTR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV38", "type": "external" } ], "mass": 55409.0, "length": 501, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 5", "gene_name": "Slc2a5", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 5", "refseq_ac": [ { "id": "NP_062715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062715", "type": "external" } ], "gene_names_uniprotkb": "Slc2a5; Glut5", "gene_names_refseq": "Glut5; Slc2a5; Slc5a", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; GLUT-5; Glucose transporter type 5, small intestine", "protein_names_refseq": "GLUT-5; fructose transporter; glucose transporter type 5, small intestine; solute carrier family 2, facilitated glucose transporter member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56485); (R-MMU-6798695); (R-MMU-8981373)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12031501;18417103;18496516;19082670;19091748;26071406", "class_list": "glycogene", "function": "Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (PubMed:19091748). Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; MRNA expression of GLUT5 varied diurnally in the duodenum, jejunum and ileum mucosa. GLUT5 protein level varied diurnally in duodenum and jejunum, but not in the ileum., [RefSeq, PubMed]; The essential role of chloride and fructose absorbing Slc2a5 is reported., [RefSeq, PubMed]; We conclude that Glut5 is not required for OHC motility or cochlear amplification., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1N7", "ec_number_list": [], "go_molecular_function": "GO:0070061 fructose binding;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0009750 response to fructose;GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal;GO:0015755 fructose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WV38-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61768-1", "uniprot_id": [ { "id": "KINH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61768", "type": "external" } ], "mass": 109551.0, "length": 963, "protein_name": "Kinesin-1 heavy chain", "gene_name": "Kif5b", "organism": "Mouse", "refseq_name": "kinesin-1 heavy chain", "refseq_ac": [ { "id": "NP_032474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032474", "type": "external" } ], "gene_names_uniprotkb": "Kif5b; Khcs; Kns1", "gene_names_refseq": "Khcs; Khc; Kif5b; Kns1; Ukhc", "protein_names_uniprotkb": "Kinesin-1 heavy chain; Conventional kinesin heavy chain; UKHC; Ubiquitous kinesin heavy chain", "protein_names_refseq": "conventional kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; kinesin-1 heavy chain; ubiquitous kinesin heavy chain", "tax_id": 10090, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:16573); (R-MMU-2132295); (R-MMU-5625970); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11986669;17242355;17532644;19886865;21183079;21750661;21976701;24129315;33300544;34428180;34887587;36288343;37934770;38451812;39627609;8170981;9112396;9657148", "class_list": "", "function": "Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo., [RefSeq, PubMed]; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08711;Q5BL10;Q61580", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0099641 anterograde axonal protein transport;GO:0006839 mitochondrial transport;GO:0042391 regulation of membrane potential;GO:0090316 positive regulation of intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q61768-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70309-1", "uniprot_id": [ { "id": "ITB5_MOUSE", "url": "https://www.uniprot.org/uniprot/O70309", "type": "external" } ], "mass": 87909.0, "length": 798, "protein_name": "Integrin beta-5", "gene_name": "Itgb5", "organism": "Mouse", "refseq_name": "integrin beta-5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001139356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139356", "type": "external" } ], "gene_names_uniprotkb": "Itgb5", "gene_names_refseq": "ESTM23; Itgb5; [b]-5; [b]5A; [b]5B; [b]5; beta-5; beta5", "protein_names_uniprotkb": "Integrin beta-5", "protein_names_refseq": "integrin beta-5 isoform 1 precursor", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:16419); (R-MMU-1236973); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-445355)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11805835;12606711;21750661;25428506;30899004;33300544;37500497;38199575;9531507;9880508", "class_list": "", "function": "Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand., [UniProtKB, UniProtKB, UniProtKB]; Integrin beta5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy., [RefSeq, PubMed]; PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O70308;O88347", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0031252 cell leading edge", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0033627 cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O70309-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24063-1", "uniprot_id": [ { "id": "ITAL_MOUSE", "url": "https://www.uniprot.org/uniprot/P24063", "type": "external" } ], "mass": 128314.0, "length": 1162, "protein_name": "Integrin alpha-L", "gene_name": "Itgal", "organism": "Mouse", "refseq_name": "integrin alpha-L isoform 3 precursor", "refseq_ac": [ { "id": "NP_001240802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240802", "type": "external" } ], "gene_names_uniprotkb": "Itgal; Lfa-1; Ly-15", "gene_names_refseq": "(p180); Cd11a; Itgal; LFA-1A; LFA-1; Ly-15; Ly-21", "protein_names_uniprotkb": "Integrin alpha-L; CD11 antigen-like family member A; LFA-1A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; Ly-15; Lymphocyte antigen 15", "protein_names_refseq": "CD11 antigen-like family member A; alpha L integrin; integrin alpha-L isoform 3 precursor; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide", "tax_id": 10090, "disease": "nephritis (Disease Ontology:DOID:10952)", "pathway": " (mmu:16408); (R-MMU-198933); (R-MMU-202733); (R-MMU-216083); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16234355;2051027;21750661;24158516;25108025;29100055;29187734;37507081;3887182;39627609", "class_list": "", "function": "Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:2051027). Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:16234355, PubMed:24158516). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (By similarity). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (PubMed:25108025). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). Integrins ITGAL:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion. Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "E9Q5M7;E9QNL8;Q3U159", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding;GO:0030369 ICAM-3 receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007166 cell surface receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P24063-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BR86-1", "uniprot_id": [ { "id": "KIRR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BR86", "type": "external" } ], "mass": 85405.0, "length": 778, "protein_name": "Kin of IRRE-like protein 3", "gene_name": "Kirrel3", "organism": "Mouse", "refseq_name": "kin of IRRE-like protein 3 isoform A precursor", "refseq_ac": [ { "id": "NP_001177840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177840", "type": "external" } ], "gene_names_uniprotkb": "Kirrel3; Kiaa1867; Neph2", "gene_names_refseq": "1500010O20Rik; 2900036G11Rik; Kirrel3; NEPH2; SST4; mKIAA1867", "protein_names_uniprotkb": "Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2; mKirre", "protein_names_refseq": "X kin of IRRE like 3; kin of IRRE-like protein 3 isoform A precursor; kin of IRRE-like protein 3; kin of irregular chiasm-like protein 3; membrane protein mKirre; nephrin-like protein 2", "tax_id": 10090, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:67703); (R-MMU-373753)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12665856;15843475;15908127;16874800;18022324;18752272;21241806;21750661;23637329;25428506;26283919;26575286;30899004;34203471;34731636", "class_list": "", "function": "In the adult brain, Neph2 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph2 is seen in dendritic shafts of pyramidal neurons., [RefSeq, PubMed]; Involved in the hematopoietic supportive capacity of OP9 mouse stromal cells, [RefSeq, PubMed]; Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors., [RefSeq, PubMed]; Results suggest that Kirrel3 plays a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin., [RefSeq, PubMed]; Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286). Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329). May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856)., [UniProtKB, PubMed, PubMed, PubMed]; The spatiotemporal expression pattern of mKirre mRNA suggests important roles of mKirre in later developmental processes, especially the synapse formation., [RefSeq, PubMed]; These results suggest that mKirre may be involved in the establishment of the pathway from sensory organs to the brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6P555;Q810H3;Q8BGQ5;Q8BRS8", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0001764 neuron migration;GO:0021766 hippocampus development;GO:0048812 neuron projection morphogenesis;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BR86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDD8-1", "uniprot_id": [ { "id": "KCD20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDD8", "type": "external" } ], "mass": 47068.0, "length": 419, "protein_name": "BTB/POZ domain-containing protein KCTD20", "gene_name": "Kctd20", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD20 isoform 1", "refseq_ac": [ { "id": "NP_080164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080164", "type": "external" } ], "gene_names_uniprotkb": "Kctd20", "gene_names_refseq": "2410004N11Rik; D17Ertd562e; Kctd20", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD20; Potassium channel tetramerization domain containing 20", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD20 isoform 1; BTB/POZ domain-containing protein KCTD20; potassium channel tetramerization domain containing 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:66989)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11017099;12563259;14579274;16761314;17363906;20173027;21590766;21750661;24156551;25605945;31219806;34428180", "class_list": "", "function": "Promotes the phosphorylation of AKT family members., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKH8;Q5U5Z7;Q9CSC4;Q9CWT1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042327 positive regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CDD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55236-1", "uniprot_id": [ { "id": "MCE1_MOUSE", "url": "https://www.uniprot.org/uniprot/O55236", "type": "external" } ], "mass": 68684.0, "length": 597, "protein_name": "mRNA-capping enzyme", "gene_name": "Rngtt", "organism": "Mouse", "refseq_name": "mRNA-capping enzyme isoform 1", "refseq_ac": [ { "id": "NP_036014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036014", "type": "external" } ], "gene_names_uniprotkb": "Rngtt; Cap1a", "gene_names_refseq": "HCE; MCE1; Rngtt", "protein_names_uniprotkb": "mRNA-capping enzyme; GTP--RNA guanylyltransferase; GTase; HCE; MCE1; mRNA 5'-phosphatase", "protein_names_refseq": "mRNA-capping enzyme isoform 1; mRNA-capping enzyme", "tax_id": 10090, "disease": "", "pathway": " (mmu:24018); (R-MMU-72086); (R-MMU-77075)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11350947;16342145;21683636;25428506;30084848;31219806;34428180;9371772;9407024;9770468", "class_list": "", "function": "Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate., [UniProtKB, PubMed, PubMed]; Overall, both in vivo and in vitro studies indicate that the functional domain of Mce1 is between a.a. 211 and 567, and the heptapeptide sequence between 561 and 567 may play an important role in the enzyme activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.50", "type": "external" }, { "id": "3.6.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.74", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004484 mRNA guanylyltransferase activity;GO:0008192 RNA guanylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006396 RNA processing;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O55236-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTJ9-1", "uniprot_id": [ { "id": "MYPN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTJ9", "type": "external" } ], "mass": 144114.0, "length": 1315, "protein_name": "Myopalladin", "gene_name": "Mypn", "organism": "Mouse", "refseq_name": "myopalladin", "refseq_ac": [ { "id": "NP_892037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892037", "type": "external" } ], "gene_names_uniprotkb": "Mypn; Kiaa4170", "gene_names_refseq": "1110056A04Rik; 9830112J03; Mypn; mKIAA4170", "protein_names_uniprotkb": "Myopalladin", "protein_names_refseq": "myopalladin", "tax_id": 10090, "disease": "dilated cardiomyopathy 1KK (Disease Ontology:DOID:0110445); nemaline myopathy 11 (Disease Ontology:DOID:0110933); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (mmu:68802)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;30016717;36288343;39927985", "class_list": "", "function": "Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPW5;Q8BZ76", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0008092 cytoskeletal protein binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045214 sarcomere organization;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5DTJ9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99104-1", "uniprot_id": [ { "id": "MYO5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99104", "type": "external" } ], "mass": 215538.0, "length": 1853, "protein_name": "Unconventional myosin-Va", "gene_name": "Myo5a", "organism": "Mouse", "refseq_name": "unconventional myosin-Va", "refseq_ac": [ { "id": "NP_034994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034994", "type": "external" } ], "gene_names_uniprotkb": "Myo5a; Dilute", "gene_names_refseq": "9630007J19Rik; Dbv; MVa; Myo5a; Myo5; MyoVA; Sev-1; d-120J; d; flail; flr", "protein_names_uniprotkb": "Unconventional myosin-Va; Dilute myosin heavy chain, non-muscle", "protein_names_refseq": "dilute lethal-20J protein; dilute myosin heavy chain, non-muscle; flailer; myosin-Va; unconventional myosin-Va", "tax_id": 10090, "disease": "Griscelli syndrome type 1 (Disease Ontology:DOID:0060832)", "pathway": " (mmu:17918); (R-MMU-2029482); (R-MMU-9824585)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11887186;12147688;12221080;15345747;16452087;17151196;19144319;1996138;21183079;21750661;22908308;23798443;29187734;30084848;31219806;33300544;34428180;34887587;37315734;38787453", "class_list": "", "function": "BMP-2 regulates the expression of myosin Va via smad in melan-a melanocyte. Publication Status: Online-Only, [RefSeq, PubMed]; Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane., [RefSeq, PubMed]; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9PUE5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0048820 hair follicle maturation;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q99104-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64331-1", "uniprot_id": [ { "id": "MYO6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64331", "type": "external" } ], "mass": 145806.0, "length": 1262, "protein_name": "Unconventional myosin-VI", "gene_name": "Myo6", "organism": "Mouse", "refseq_name": "unconventional myosin-VI isoform 3", "refseq_ac": [ { "id": "NP_001034635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034635", "type": "external" } ], "gene_names_uniprotkb": "Myo6; Sv", "gene_names_refseq": "Myo6; Myo6; Tlc; rsv; sv", "protein_names_uniprotkb": "Unconventional myosin-VI; Protein twist; Unconventional myosin-6", "protein_names_refseq": "Snell's waltzer; protein twist; tailchaser; unconventional myosin-6; unconventional myosin-VI isoform 3; unconventional myosin-VI", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 37 (Disease Ontology:DOID:0110495); autosomal dominant nonsyndromic deafness 22 (Disease Ontology:DOID:0110552); sensorineural hearing loss (Disease Ontology:DOID:10003); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (mmu:17920); (R-MMU-190873); (R-MMU-399719); (R-MMU-9013418); (R-MMU-9013420); (R-MMU-9013422)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11906161;17329413;21183079;21750661;22039235;23023224;24285636;34887587;36064721;37507081;7493015", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity (PubMed:11906161). Unconventional myosins serve in intracellular movements (PubMed:11906161). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (By similarity). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (PubMed:11906161). May play a role in the extension and network organization of neurites (PubMed:22039235). Required for structural integrity of inner ear hair cells (PubMed:7493015). Required for the correct localization of CLIC5 and RDX at the stereocilium base (PubMed:24285636). Modulates RNA polymerase II-dependent transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q3L1", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64331-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27573-1", "uniprot_id": [ { "id": "MYP0_MOUSE", "url": "https://www.uniprot.org/uniprot/P27573", "type": "external" } ], "mass": 27622.0, "length": 248, "protein_name": "Myelin protein P0", "gene_name": "Mpz", "organism": "Mouse", "refseq_name": "myelin protein P0 isoform MPZ precursor", "refseq_ac": [ { "id": "NP_001302428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001302428", "type": "external" } ], "gene_names_uniprotkb": "Mpz; P0", "gene_names_refseq": "Mpp; Mpz; P-zero; P0", "protein_names_uniprotkb": "Myelin protein P0; MPP; Myelin peripheral protein; Myelin protein zero", "protein_names_refseq": "myelin peripheral protein; myelin protein P0 isoform MPZ precursor; myelin protein P0", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); PCWH syndrome (Disease Ontology:DOID:0090111); Charcot-Marie-Tooth disease type 1B (Disease Ontology:DOID:0110152); Charcot-Marie-Tooth disease type 2J (Disease Ontology:DOID:0110157); Charcot-Marie-Tooth disease type 2I (Disease Ontology:DOID:0110158); Charcot-Marie-Tooth disease dominant intermediate D (Disease Ontology:DOID:0110200); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); sciatic neuropathy (Disease Ontology:DOID:11446); neuropathy (Disease Ontology:DOID:870); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:17528)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10068633;1709914;21750661;22457349;24354407;25428506;37507081;39927985;7530295", "class_list": "", "function": "Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough., [RefSeq, PubMed]; This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q542C9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042552 myelination;GO:0098609 cell-cell adhesion;GO:0098743 cell aggregation;GO:0045217 cell-cell junction maintenance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P27573-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VQB6-1", "uniprot_id": [ { "id": "MYO10_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VQB6", "type": "external" } ], "mass": 237323.0, "length": 2062, "protein_name": "Unconventional myosin-X", "gene_name": "Myo10", "organism": "Mouse", "refseq_name": "unconventional myosin-X isoform 1", "refseq_ac": [ { "id": "NP_062345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062345", "type": "external" } ], "gene_names_uniprotkb": "Myo10", "gene_names_refseq": "D15Ertd600e; Myo10; mKIAA0799; myosin-X", "protein_names_uniprotkb": "Unconventional myosin-X; Unconventional myosin-10", "protein_names_refseq": "unconventional myosin-10; unconventional myosin-X isoform 1; unconventional myosin-X; unconventionnal myosin-X", "tax_id": 10090, "disease": "", "pathway": " (mmu:17909); (R-MMU-2029482)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10799329;16030012;17237772;20081229;21750661;22661706;23943878;25428506;30779550;31219806;34428180;35470858", "class_list": "", "function": "Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion., [UniProtKB, PubMed]; MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesisdagger., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (By similarity). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3S0;Q9JJY5", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030027 lamellipodium", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0008360 regulation of cell shape;GO:0048870 cell motility;GO:0051489 regulation of filopodium assembly;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F8VQB6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70365-1", "uniprot_id": [ { "id": "NCOA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70365", "type": "external" } ], "mass": 157016.0, "length": 1447, "protein_name": "Nuclear receptor coactivator 1", "gene_name": "Ncoa1", "organism": "Mouse", "refseq_name": "nuclear receptor coactivator 1 isoform 1", "refseq_ac": [ { "id": "NP_035011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035011", "type": "external" } ], "gene_names_uniprotkb": "Ncoa1; Src1", "gene_names_refseq": "KAT13A; NCoA-1; NRC-1; Ncoa1; SRC-1; SRC-a; SRC1; bHLHe74; mNRC-1", "protein_names_uniprotkb": "Nuclear receptor coactivator 1; 2.3.1.48; NCoA-1; Nuclear receptor coactivator protein 1; SRC-1; Steroid receptor coactivator 1; mNRC-1", "protein_names_refseq": "nuclear receptor coactivator 1 isoform 1; nuclear receptor coactivator protein 1; steroid receptor coactivator 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); hypothyroidism (Disease Ontology:DOID:1459); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17977); (R-MMU-159418); (R-MMU-192105); (R-MMU-193368); (R-MMU-193807); (R-MMU-211976); (R-MMU-3214847); (R-MMU-3899300); (R-MMU-400206); (R-MMU-9018519); (R-MMU-9029569); (R-MMU-9623433); (R-MMU-9707564)", "pathway_count": 13, "publication_count": 26, "publication_id_list": "10381882;12507421;12709428;14757047;16148126;19144319;21183079;21750661;22517741;22645316;24129315;30084848;32782141;32848054;34428180;34678516;36852467;36878279;38730334;40021952;40885482;8616895;8855229;9041124;9192892;9506940", "class_list": "", "function": "Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration., [RefSeq, PubMed]; NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P70366;Q61202;Q66JL7;Q8CBI9", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "1.14.14.26", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.26", "type": "external" }, { "id": "1.14.14.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.29", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "1.14.14.23", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.23", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060179 male mating behavior;GO:1904179 positive regulation of adipose tissue development;GO:0002155 regulation of thyroid hormone receptor signaling pathway;GO:1900076 regulation of cellular response to insulin stimulus;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P70365-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97479-1", "uniprot_id": [ { "id": "MYO7A_MOUSE", "url": "https://www.uniprot.org/uniprot/P97479", "type": "external" } ], "mass": 254939.0, "length": 2215, "protein_name": "Unconventional myosin-VIIa", "gene_name": "Myo7a", "organism": "Mouse", "refseq_name": "unconventional myosin-VIIa isoform 1", "refseq_ac": [ { "id": "NP_001243010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243010", "type": "external" } ], "gene_names_uniprotkb": "Myo7a; Myo7", "gene_names_refseq": "Hdb; Myo7a; Myo7; USH1B; nmf371; polka; sh-1; sh1", "protein_names_uniprotkb": "Unconventional myosin-VIIa", "protein_names_refseq": "motor protein; myosin 7A; myosin-VIIa; shaker 1; unconventional myosin-VIIa isoform 1; unconventional myosin-VIIa", "tax_id": 10090, "disease": "Usher syndrome type 1B (Disease Ontology:DOID:0070655); autosomal recessive nonsyndromic deafness 2 (Disease Ontology:DOID:0110477); autosomal dominant nonsyndromic deafness 11 (Disease Ontology:DOID:0110543); Usher syndrome type 1 (Disease Ontology:DOID:0110826); sensorineural hearing loss (Disease Ontology:DOID:10003); Leber congenital amaurosis (Disease Ontology:DOID:14791); auditory system disease (Disease Ontology:DOID:2742); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": " (mmu:17921); (R-MMU-2453902)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12221080;15590698;15654330;15976448;16481439;17567809;19774077;21183079;21311020;21493626;21709241;21750661;25428506;27331610;27525485;30084848;31219806;34428180;35820727;7870172;9680294", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLP7;Q5MJ57", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0051875 pigment granule localization;GO:0042490 mechanoreceptor differentiation;GO:0006886 intracellular protein transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97479-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1X4-1", "uniprot_id": [ { "id": "NCKPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1X4", "type": "external" } ], "mass": 128905.0, "length": 1134, "protein_name": "Nck-associated protein 1-like", "gene_name": "Nckap1l", "organism": "Mouse", "refseq_name": "nck-associated protein 1-like", "refseq_ac": [ { "id": "NP_705725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705725", "type": "external" } ], "gene_names_uniprotkb": "Nckap1l; Hem1", "gene_names_refseq": "4930568P13Rik; Hem1; Hemp1; Nckap1l", "protein_names_uniprotkb": "Nck-associated protein 1-like; Hematopoietic protein 1", "protein_names_refseq": "hematopoietic protein 1; nck-associated protein 1-like", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); immunodeficiency 72 (Disease Ontology:DOID:0112015)", "pathway": " (mmu:105855); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-6798695); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "18250455;19015308;21750661;23424621;25605945;34428180;35531955;36574841", "class_list": "", "function": "A novel, critical role for Hem-1 in the homeostasis of structural proteins required for formation and stability of the actin membrane skeleton in erythrocytes, [RefSeq, PubMed]; Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:19015308, PubMed:23424621). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization (PubMed:23424621). Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (PubMed:19015308). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells. Required for efficient T-lymphocyte and neutrophil migration (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE independent to regulate myosin and actin polymerization during neutrophil chemotaxis (By similarity). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner. Publication Status: Online-Only, [RefSeq, PubMed]; Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice., [RefSeq, PubMed]; Results demonstrate that Hem1 is essential for hematopoietic cell development, function, and homeostasis by controlling a distinct pathway leading to cytoskeletal reorganization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0030295 protein kinase activator activity;GO:0044877 protein-containing complex binding;GO:1904841 TORC2 complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031209 SCAR complex", "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0032700 negative regulation of interleukin-17 production;GO:0006935 chemotaxis;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K1X4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00175-1", "uniprot_id": [ { "id": "PRGR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00175", "type": "external" } ], "mass": 98981.0, "length": 926, "protein_name": "Progesterone receptor", "gene_name": "Pgr", "organism": "Mouse", "refseq_name": "progesterone receptor", "refseq_ac": [ { "id": "NP_032855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032855", "type": "external" } ], "gene_names_uniprotkb": "Pgr; Nr3c3; Pr", "gene_names_refseq": "9930019P03Rik; NR3C3; PR-A; PR-B; PR; Pgr", "protein_names_uniprotkb": "Progesterone receptor; Nuclear receptor subfamily 3 group C member 3; PR", "protein_names_refseq": "nuclear receptor subfamily 3 group C member 3; progesterone receptor", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700); endometriosis (Disease Ontology:DOID:289); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18667); (R-MMU-3371497); (R-MMU-383280); (R-MMU-4090294); (R-MMU-9018519)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10976068;12672823;15044369;15878961;16728408;17003284;2069958;7802637;8603049", "class_list": "", "function": "Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2., [UniProtKB, UniProtKB]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor., [UniProtKB, UniProtKB]; This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6A5;E9QPW3", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0060180 female mating behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q00175-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIW1-1", "uniprot_id": [ { "id": "PRUN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIW1", "type": "external" } ], "mass": 50239.0, "length": 454, "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "Prune1", "organism": "Mouse", "refseq_name": "exopolyphosphatase PRUNE1", "refseq_ac": [ { "id": "NP_775482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775482", "type": "external" } ], "gene_names_uniprotkb": "Prune1; Prune", "gene_names_refseq": "9230112O05Rik; C130058A12; DRES-17; HTCD37; PRUNEM1; Prune-M1; Prune1; Prune", "protein_names_uniprotkb": "Exopolyphosphatase PRUNE1; 3.6.1.14; 3.6.1.25; PRUNEM1", "protein_names_refseq": "exopolyphosphatase PRUNE1; protein prune homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:229589)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10602478;21183079;25138575;25153642;28135057;28528544;31219806;34428180;36210013", "class_list": "", "function": "A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction, [RefSeq, PubMed]; Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues. Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates. Requires divalent metal ions for activity. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80VU0", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity;GO:0004309 exopolyphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BIW1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCF0-1", "uniprot_id": [ { "id": "PRP31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCF0", "type": "external" } ], "mass": 55430.0, "length": 499, "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp31", "gene_name": "Prpf31", "organism": "Mouse", "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp31 isoform 2", "refseq_ac": [ { "id": "NP_001153186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153186", "type": "external" } ], "gene_names_uniprotkb": "Prpf31; Prp31", "gene_names_refseq": "1500019O16Rik; 2810404O06Rik; PRP31; Prpf31; RP11", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31; Protein 61K; U4/U6 snRNP 61 kDa protein", "protein_names_refseq": "PRP31 pre-mRNA processing factor 31 homolog; U4/U6 small nuclear ribonucleoprotein Prp31 isoform 2; U4/U6 small nuclear ribonucleoprotein Prp31; U4/U6 snRNP 61 kDa protein; protein 61K", "tax_id": 10090, "disease": "retinitis pigmentosa 11 (Disease Ontology:DOID:0110408); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:68988); (R-MMU-72163)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11867543;15659613;17350276;19578015;19892989;20811066;21183079;23806337;25428506;31884616;31892304;34428180;36088804", "class_list": "", "function": "In a mouse model containing the p.A216P mutation in Prpf31, study found mislocalization and aggregation of the mutant Prpf31 protein with concomitant depletion of normal protein. These results indicate mixed haploinsufficiency and dominant negative mechanisms involved in retinal degeneration due to mutations in PRPF31. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome., [UniProtKB, UniProtKB]; Major retinal pigment epithelium defects were identified in Prpf31-mutant mice, [RefSeq, PubMed]; Our results demonstrate that mutations in PRPF31 gene affect rhodopsin (RHO) pre-mRNA splicing and reveal a link between PRPF31 and RHO, two major genes in autosomal dominant retinitis pigmentosa., [RefSeq, PubMed]; Our results indicate that PRPF31 mutations lead to defective pre-mRNA splicing of photoreceptor-specific genes and that the ubiquitously expressed adRP gene, PRPF31, is critical for pre-mRNA splicing of a subset of photoreceptor genes., [RefSeq, PubMed]; PRPF31 interacts with PRPH2 confirmed by co-immunoprecipitation and co-localization., [RefSeq, PubMed]; The finding of similar degenerative changes in RPE cells of all three mouse models suggests that the retinal pigment epithelium may be the primary cell type affected in the RNA splicing factor forms of retinitis pigmentosa. Publication Status: Online-Only, [RefSeq, PubMed]; The results imply that Prpf31 is necessary for survival, and there is no compensation mechanism in mouse for the lack of this splicing factor, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPM6;Q6P7X2;Q8BQ91;Q8C8U4;Q8C8V5;Q8CCG6;Q8CF52;Q8VBW3", "ec_number_list": [], "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0030622 U4atac snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0071166 ribonucleoprotein complex localization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CCF0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48281-1", "uniprot_id": [ { "id": "VDR_MOUSE", "url": "https://www.uniprot.org/uniprot/P48281", "type": "external" } ], "mass": 47834.0, "length": 422, "protein_name": "Vitamin D3 receptor", "gene_name": "Vdr", "organism": "Mouse", "refseq_name": "vitamin D3 receptor", "refseq_ac": [ { "id": "NP_033530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033530", "type": "external" } ], "gene_names_uniprotkb": "Vdr; Nr1i1", "gene_names_refseq": "Nr1i1; Vdr", "protein_names_uniprotkb": "Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR", "protein_names_refseq": "1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1; vitamin D receptor; vitamin D3 receptor", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); erythema nodosum (Disease Ontology:DOID:0080750); vitamin D-dependent rickets (Disease Ontology:DOID:0080883); vitamin D-dependent rickets type 2A (Disease Ontology:DOID:0080884); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); pigmentation disease (Disease Ontology:DOID:10123); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); gestational diabetes (Disease Ontology:DOID:11714); myopia (Disease Ontology:DOID:11830); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Behcet's disease (Disease Ontology:DOID:13241); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); Turner syndrome (Disease Ontology:DOID:3491); tuberculosis (Disease Ontology:DOID:399); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); hematopoietic system disease (Disease Ontology:DOID:74); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); Barrett's esophagus (Disease Ontology:DOID:9206); cholangitis (Disease Ontology:DOID:9446); steatotic liver disease (Disease Ontology:DOID:9452); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:22337); (R-MMU-196791); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12016314;14528024;21750661;28751364;29187734;32354638;7835717", "class_list": "", "function": "Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:32354638). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 56, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922X0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043235 receptor complex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:0060745 mammary gland branching involved in pregnancy;GO:0038185 nuclear receptor-mediated bile acid signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48281-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUQ2-1", "uniprot_id": [ { "id": "SEC12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUQ2", "type": "external" } ], "mass": 45437.0, "length": 417, "protein_name": "Guanine nucleotide-exchange factor SEC12", "gene_name": "Preb", "organism": "Mouse", "refseq_name": "guanine nucleotide-exchange factor SEC12 isoform 1", "refseq_ac": [ { "id": "NP_057912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057912", "type": "external" } ], "gene_names_uniprotkb": "Preb; Sec12", "gene_names_refseq": "Preb; mSec12", "protein_names_uniprotkb": "Guanine nucleotide-exchange factor SEC12; Mammalian guanine nucleotide exchange factor Sec12; Prolactin regulatory element-binding protein; mSec12", "protein_names_refseq": "guanine nucleotide-exchange factor SEC12 isoform 1; guanine nucleotide-exchange factor SEC12; mammalian guanine nucleotide exchange factor Sec12; mammalian guanine nucleotide exchange factor mSec12; prolactin regulatory element-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:50907); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10704286;11422940;16800626;21750661;21952136;22872234;25428506;29601978;30084848;31219806;34428180;35820727;36210013;37453647", "class_list": "", "function": "Glucose, insulin, and pyruvate tolerance were impaired in normal mice knocked down for Preb indicating Preb to be a negative regulator of liver gluconeogenic genes., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:11422940). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ99", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051020 GTPase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WUQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGT6-1", "uniprot_id": [ { "id": "PIWL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGT6", "type": "external" } ], "mass": 95773.0, "length": 848, "protein_name": "Piwi-like protein 4", "gene_name": "Piwil4", "organism": "Mouse", "refseq_name": "piwi-like protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001355760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355760", "type": "external" } ], "gene_names_uniprotkb": "Piwil4; Miwi2", "gene_names_refseq": "9230101H05Rik; Miwi2; Piwil4; mAgo5", "protein_names_uniprotkb": "Piwi-like protein 4; mAgo5", "protein_names_refseq": "piwi-like 4; piwi-like homolog 4; piwi-like protein 4 isoform 1; piwi-like protein 4", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:330890)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12414724;17395546;18381894;18922463;19465913;19584108;20534472;20547853;21750661;22020280;23714778;25038252;26669262;30084848;32381626;32674113;32719317;35820727;38359823;39294378", "class_list": "", "function": "Data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation of retrotransposons in fetal male germ cells., [RefSeq, PubMed]; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:22020280, PubMed:26669262, PubMed:38359823). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:22020280, PubMed:26669262, PubMed:38359823). The PIWIL4-piRNA pathway acts in the nucleus and mediates silencing of active transposons: engages with nascent transposable element transcripts and governs the piRNA-directed DNA methylation and subsequent repression of transposons (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:22020280, PubMed:26669262, PubMed:38359823). In contrast to PIWIL1 and PIWIL2, does not show endonuclease activity (PubMed:22020280). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:22020280, PubMed:26669262). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:22020280, PubMed:26669262). The piRNA process acts upstream of known mediators of DNA methylation (PubMed:17395546, PubMed:18381894, PubMed:18922463, PubMed:22020280, PubMed:26669262). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (PubMed:22020280). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Two-factor authentication underpins the precision of the piRNA pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6P4B9;A6X963;A6X964;Q8CC75", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0034584 piRNA binding;GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CGT6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JK39-1", "uniprot_id": [ { "id": "ITA9_MOUSE", "url": "https://www.uniprot.org/uniprot/B8JK39", "type": "external" } ], "mass": 114416.0, "length": 1036, "protein_name": "Integrin alpha-9", "gene_name": "Itga9", "organism": "Mouse", "refseq_name": "integrin alpha-9 isoform a precursor", "refseq_ac": [ { "id": "NP_598482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598482", "type": "external" } ], "gene_names_uniprotkb": "Itga9", "gene_names_refseq": "(alpha)9; 2610002H11Rik; 6720458D17Rik; D130073C02; D9Ertd428e; Itga9", "protein_names_uniprotkb": "Integrin alpha-9", "protein_names_refseq": "integrin alpha-9 isoform a precursor", "tax_id": 10090, "disease": "congenital chylothorax (Disease Ontology:DOID:0060646); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); pancreatic cancer (Disease Ontology:DOID:1793); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:104099); (R-MMU-216083); (R-MMU-3000178); (R-MMU-445144)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11805835;21750661;22654117;25428506;28179430;28179432;34428180;35802072;37224018;39002785;8245132", "class_list": "", "function": "Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis., [RefSeq, PubMed]; Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (PubMed:22654117). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072)., [UniProtKB, PubMed, PubMed]; Integrin-alpha9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B9EKC4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0098640 integrin binding involved in cell-matrix adhesion;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0009925 basal plasma membrane;GO:0034679 integrin alpha9-beta1 complex;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion;GO:0045906 negative regulation of vasoconstriction;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "B8JK39-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBX6-1", "uniprot_id": [ { "id": "MPDZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBX6", "type": "external" } ], "mass": 218711.0, "length": 2055, "protein_name": "Multiple PDZ domain protein", "gene_name": "Mpdz", "organism": "Mouse", "refseq_name": "multiple PDZ domain protein isoform 1", "refseq_ac": [ { "id": "NP_001292213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292213", "type": "external" } ], "gene_names_uniprotkb": "Mpdz; Mupp1", "gene_names_refseq": "B930003D11Rik; MUPP1; Mpdz", "protein_names_uniprotkb": "Multiple PDZ domain protein; Multi-PDZ domain protein 1", "protein_names_refseq": "multi-PDZ domain protein 1; multiple PDZ domain protein isoform 1; multiple PDZ domain protein", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:17475)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10395806;10967549;11000240;11018522;11689568;11978849;12403818;12706259;15316081;15364909;15509766;17242355;19506035;21750661;22872234;23001562;24129315;25428506;30084848;34203471;34428180;35820727;36210013;37318097;9192623", "class_list": "", "function": "Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). Promotes clustering of HT2RC at the cell surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PATJ and MPDZ are required for trophectoderm lineage specification in early mouse embryos. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNA1;O08783;Q6P7U4;Q80ZY8;Q8BKJ1;Q8C0H8;Q8VBV5;Q8VBY0;Q9Z1K3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0120192 tight junction assembly;GO:0006886 intracellular protein transport;GO:0007155 cell adhesion;GO:0016358 dendrite development;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8VBX6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRH4-1", "uniprot_id": [ { "id": "KMT2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRH4", "type": "external" } ], "mass": 540187.0, "length": 4903, "protein_name": "Histone-lysine N-methyltransferase 2C", "gene_name": "Kmt2c", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kmt2c; Mll3", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase 2C; 2.1.1.364; Lysine N-methyltransferase 2C; Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); Kleefstra syndrome 2 (Disease Ontology:DOID:0080598); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); congenital heart disease (Disease Ontology:DOID:1682); squamous cell carcinoma (Disease Ontology:DOID:1749); laryngeal carcinoma (Disease Ontology:DOID:2600); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); Klatskin's tumor (Disease Ontology:DOID:4927); stomach carcinoma (Disease Ontology:DOID:5517); rheumatoid arthritis (Disease Ontology:DOID:7148); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:231051); (R-MMU-3214841); (R-MMU-8936459); (R-MMU-9772755); (R-MMU-9818564)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11718452;16459028;21183079;21750661;23806337;24129315;25428506;29187734;30084848;31219806;31599954;34428180;36852467;40997131", "class_list": "", "function": "Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 14, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q5YLV9;Q8BK12;Q8C6M3;Q923H5;Q923H6", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042054 histone methyltransferase activity;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007338 single fertilization;GO:0035264 multicellular organism growth;GO:0048146 positive regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BRH4-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8M7-1", "uniprot_id": [ { "id": "PHF10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8M7", "type": "external" } ], "mass": 55840.0, "length": 497, "protein_name": "PHD finger protein 10", "gene_name": "Phf10", "organism": "Mouse", "refseq_name": "PHD finger protein 10 isoform 1", "refseq_ac": [ { "id": "NP_077212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077212", "type": "external" } ], "gene_names_uniprotkb": "Phf10; Baf45a", "gene_names_refseq": "1810055P05Rik; Phf10", "protein_names_uniprotkb": "PHD finger protein 10; BAF45a; BRG1-associated factor 45a", "protein_names_refseq": "BAF45a; BRG1-associated factor 45a; PHD finger protein 10 isoform 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (mmu:72057); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9934037)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "17640523;19144319;21183079;21750661;25153642;28135057;28528544;31219806;34428180;35820727;36210013;38189889", "class_list": "", "function": "Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth., [UniProtKB, PubMed]; Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLI2;Q99LV5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071564 npBAF complex;GO:0016363 nuclear matrix;GO:0000776 kinetochore", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D8M7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PF93-1", "uniprot_id": [ { "id": "PK3C3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PF93", "type": "external" } ], "mass": 101487.0, "length": 887, "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "Pik3c3", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3-kinase catalytic subunit type 3", "refseq_ac": [ { "id": "NP_852079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852079", "type": "external" } ], "gene_names_uniprotkb": "Pik3c3; Vps34", "gene_names_refseq": "5330434F23Rik; Pik3c3; Vps34", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase catalytic subunit type 3; 2.7.1.137; PI3-kinase type 3; PI3K type 3; Phosphoinositide-3-kinase class 3; PtdIns-3-kinase type 3", "protein_names_refseq": "PI3-kinase type 3; PI3K type 3; phosphatidylinositol 3-kinase catalytic subunit type 3; phosphoinositide-3-kinase, class 3; ptdIns-3-kinase type 3", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (mmu:225326); (R-MMU-109704); (R-MMU-1632852); (R-MMU-1660514); (R-MMU-1660516); (R-MMU-1660517); (R-MMU-168138); (R-MMU-5668599)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17589504;21059846;21750661;22493499;23332761;24089209;30084848;31219806;34428398;39117783;39250817;39627609", "class_list": "", "function": "Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pik3c3 expression profiling in the mouse kidney and its role in proximal tubule cell physiology., [RefSeq, PubMed]; Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3S8", "ec_number_list": [ { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005777 peroxisome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0000045 autophagosome assembly;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6PF93-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXS1-1", "uniprot_id": [ { "id": "PLEC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXS1", "type": "external" } ], "mass": 534188.0, "length": 4691, "protein_name": "Plectin", "gene_name": "Plec", "organism": "Mouse", "refseq_name": "plectin isoform 12alpha", "refseq_ac": [ { "id": "NP_001157012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157012", "type": "external" } ], "gene_names_uniprotkb": "Plec; Plec1", "gene_names_refseq": "EBS1; PCN; PLTN; Plec1; Plec", "protein_names_uniprotkb": "Plectin; PCN; PLTN; Plectin-1; Plectin-6", "protein_names_refseq": "plectin isoform 12alpha; plectin-1; plectin-6", "tax_id": 10090, "disease": "epidermolysis bullosa simplex 5A Ogna type (Disease Ontology:DOID:0060736); epidermolysis bullosa simplex with muscular dystrophy (Disease Ontology:DOID:0090017); autosomal recessive limb-girdle muscular dystrophy type 2Q (Disease Ontology:DOID:0110285); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (mmu:18810); (R-MMU-264870); (R-MMU-446107)", "pathway_count": 3, "publication_count": 47, "publication_id_list": "10.1101/2023.09.13.557529;10556294;12200133;12542521;14672974;15128297;15592455;16330710;16452087;17114649;17208939;17242355;17389230;17947660;18541706;18630941;18827015;19131326;19144319;19932097;20485683;21183079;21745462;21750661;22517741;22645316;23525008;23806337;24129315;24940650;25428507;25605945;30016717;31219806;32848054;33300544;34203471;34428180;34887587;35820727;36210013;36852467;37507081;39627609;39927985;40021952;40885482", "class_list": "", "function": "Expression of plectin 1a, but not of its N-terminal fragment alone, or of a third alternative full length isoform (plectin 1), restored the reduced number of hemidesmosome-like stable anchoring contacts in cultured plectin-null keratinocytes, [RefSeq, PubMed]; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plectin 1b both forms a mitochondrial signaling platform and affects organelle shape and network formation by tethering mitochondria to intermediate filaments., [RefSeq, PubMed]; Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]., [RefSeq]; We propose a model in which plectin acts as a universal mediator of desmin intermediate filament anchorage at the sarcolemma and Z-disks., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 39, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QN87;Q6S384;Q6S389;Q6S394;Q9CS65;Q9QUT2;Q9QXQ8;Q9QXQ9;Q9QXR0;Q9QXR1;Q9QXR2;Q9QXR3;Q9QXR4;Q9QXR5;Q9QXR6;Q9QXR7;Q9QXR8;Q9QXR9;Q9QXS0;Q9QXS2;Q9QXS3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005903 brush border;GO:0005925 focal adhesion", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0002522 leukocyte migration involved in immune response;GO:0007015 actin filament organization;GO:0007584 response to nutrient;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "Q9QXS1-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61025-1", "uniprot_id": [ { "id": "IFT20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61025", "type": "external" } ], "mass": 15237.0, "length": 132, "protein_name": "Intraflagellar transport protein 20 homolog", "gene_name": "Ift20", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 20 homolog", "refseq_ac": [ { "id": "NP_061342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061342", "type": "external" } ], "gene_names_uniprotkb": "Ift20", "gene_names_refseq": "0610009H04Rik; Ift20; mIFT20", "protein_names_uniprotkb": "Intraflagellar transport protein 20 homolog; mIFT20", "protein_names_refseq": "intraflagellar transport 20 homolog; intraflagellar transport protein 20 homolog; uterine protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:55978); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11916979;12821668;15337773;16775004;19112494;19253336;19889948;21750661;24089209;25243405;27682589;28619825;29237719;31637240;31816150;38038747;38048369", "class_list": "", "function": "Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (PubMed:27682589). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (PubMed:24089209)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This work suggests that IFT20 functions in the delivery of ciliary membrane proteins from the Golgi complex to the cilium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SYG9;Q99M35", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008542 visual learning;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0072659 protein localization to plasma membrane;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q61025-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66T02-1", "uniprot_id": [ { "id": "PKHG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66T02", "type": "external" } ], "mass": 118924.0, "length": 1073, "protein_name": "Pleckstrin homology domain-containing family G member 5", "gene_name": "Plekhg5", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family G member 5 isoform 1", "refseq_ac": [ { "id": "NP_001272928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272928", "type": "external" } ], "gene_names_uniprotkb": "Plekhg5; Kiaa0720; Syx", "gene_names_refseq": "Plekhg5; Syx", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 5; PH domain-containing family G member 5; SYX; Synectin-binding RhoA exchange factor", "protein_names_refseq": "PH domain-containing family G member 5; RhoA-specific guanine exchange factor SYX1; RhoA-specific guanine exchange factor SYX2; pleckstrin homology domain-containing family G member 5 isoform 1; synectin-binding RhoA exchange factor", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease recessive intermediate C (Disease Ontology:DOID:0110198); autosomal recessive distal hereditary motor neuronopathy 4 (Disease Ontology:DOID:0111213)", "pathway": " (mmu:269608); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9696264); (R-MMU-9696273)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "16467373;17242355;20811643;21183079;21543326;21750661;23253477;23777631;29084947;34428180;39366938", "class_list": "", "function": "A well defined Rnd3 effector Syx Publication Status: Online-Only, [RefSeq, PubMed]; Data show that pleckstrin homology containing family member 5 (Plekhg5)-depleted cultured motoneurons show defective axon growth and impaired autophagy of synaptic vesicles, which can be rescued by constitutively active ras-related protein Rab-26 (Rab26). Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (PubMed:29084947). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (PubMed:21543326). Also affects the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein belonging to the Rho guanine exchange factor (GEF) family of proteins, which activate GTPases by replacing GDP with GTP. This family member is a RhoA GEF that plays a role in endothelial cell migration and tube formation. It is required for angiogenesis and may function in neuronal cell differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A8B6;A2A8B7;Q66T00;Q6P3B1;Q6ZQ62;Q8R571", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0043542 endothelial cell migration;GO:0035767 endothelial cell chemotaxis;GO:0140251 regulation protein catabolic process at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q66T02-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBP5-1", "uniprot_id": [ { "id": "KCY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBP5", "type": "external" } ], "mass": 22165.0, "length": 196, "protein_name": "UMP-CMP kinase", "gene_name": "Cmpk1", "organism": "Mouse", "refseq_name": "UMP-CMP kinase", "refseq_ac": [ { "id": "NP_079923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079923", "type": "external" } ], "gene_names_uniprotkb": "Cmpk1; CMPK1; CMPK; Cmk; Cmpk; Uck; Umk; Umpk", "gene_names_refseq": "0610011D08Rik; CK; Cmpk1; Cmpk; UMP-CMPk", "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase", "protein_names_refseq": "UMP-CMP kinase; UMP/CMPK; cytidine monophosphate (UMP-CMP) kinase 1; cytidine monophosphate kinase; cytidylate kinase 1; dCMP kinase; deoxycytidylate kinase; likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK); nucleoside-diphosphate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:66588); (R-MMU-499943)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;23806337;25605945;26495903;34428180;37453647;37507081", "class_list": "", "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP, UniProtKB]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK17;Q8VD05;Q9DCS7", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0050145 nucleoside monophosphate kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006227 dUDP biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0006240 dCDP biosynthetic process;GO:0046705 CDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DBP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ56-1", "uniprot_id": [ { "id": "PLPL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ56", "type": "external" } ], "mass": 53657.0, "length": 486, "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "Pnpla2", "organism": "Mouse", "refseq_name": "patatin-like phospholipase domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001157161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157161", "type": "external" } ], "gene_names_uniprotkb": "Pnpla2; Atgl", "gene_names_refseq": "0610039C21Rik; 1110001C14Rik; Atgl; Pnpla2; TTS-2.2", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 2; 3.1.1.3; 3.1.1.4; Adipose triglyceride lipase; Calcium-independent phospholipase A2-zeta; Desnutrin; iPLA2-zeta", "protein_names_refseq": "adipose triglyceride lipase; calcium-independent phospholipase A2-zeta; desnutrin; iPLA2-zeta; patatin-like phospholipase domain-containing protein 2 isoform 1; patatin-like phospholipase domain-containing protein 2; transport-secretion protein; triglyceride hydrolase", "tax_id": 10090, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:66853); (R-MMU-1482883); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;15337759;15550674;16009485;16150821;16380488;16675698;16679289;16705060;17074755;17114792;17189257;21148142;21183079;21393244;21641555;21750661;22713505;22733971;23066022;25428506;25879679;30084848;31219806;33376578;34428180;35676490;9798653", "class_list": "", "function": "Adipose triglyceride lipase (desnutrin) is downregulated by isoproterenol, TNFalpha, and insulin., [RefSeq, PubMed]; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15337759, PubMed:15550674, PubMed:16150821, PubMed:16675698, PubMed:16679289, PubMed:17074755, PubMed:17114792, PubMed:23066022). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (PubMed:23066022). Also possesses acylglycerol transacylase and phospholipase A2 activities (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (By similarity). Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (By similarity). Inhibits LDAH-stimulated lipid droplet fusion (By similarity). May play an important role in energy homeostasis (PubMed:16675698). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (PubMed:15337759)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Desnutrin may have a role in the pathophysiology of obesity, [RefSeq, PubMed]; Reported that adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis; ATGL and hormone-sensitive lipase (HSL) coordinately catabolize stored triglycerides in adipose tissue [ATGL], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O89080;Q05BJ0;Q3UD97;Q643S0;Q6P234;Q9D1Q9;Q9DCF6", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0016411 acylglycerol O-acyltransferase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0051264 mono-olein transacylation activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0010891 negative regulation of triglyceride storage;GO:0010898 positive regulation of triglyceride catabolic process;GO:0055088 lipid homeostasis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8BJ56-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88898-1", "uniprot_id": [ { "id": "P63_MOUSE", "url": "https://www.uniprot.org/uniprot/O88898", "type": "external" } ], "mass": 76789.0, "length": 680, "protein_name": "Tumor protein 63", "gene_name": "Tp63; Trp63", "organism": "Mouse", "refseq_name": "tumor protein 63 isoform a", "refseq_ac": [ { "id": "NP_001120731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120731", "type": "external" } ], "gene_names_uniprotkb": "Tp63; Trp63; P63; P73l; Tp73l; Trp63", "gene_names_refseq": "Ket; P51/P63; P63; P73l; Tp63; Trp53rp1; Trp63", "protein_names_uniprotkb": "Tumor protein 63; TP63; Transformation-related protein 63; Tumor protein p73-like; p63; p73L", "protein_names_refseq": "tumor protein 63 isoform a; tumor protein 63", "tax_id": 10090, "disease": "ADULT syndrome (Disease Ontology:DOID:0050601); Rapp-Hodgkin syndrome (Disease Ontology:DOID:0060330); EEC syndrome (Disease Ontology:DOID:0060782); ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 (Disease Ontology:DOID:0060783); bladder exstrophy-epispadias-cloacal exstrophy complex (Disease Ontology:DOID:0080173); bladder exstrophy (Disease Ontology:DOID:0080174); orofacial cleft 8 (Disease Ontology:DOID:0080401); split hand-foot malformation 4 (Disease Ontology:DOID:0090023); ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (Disease Ontology:DOID:0090119); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); ectodermal dysplasia (Disease Ontology:DOID:2121); transitional cell carcinoma (Disease Ontology:DOID:2671); testicular cancer (Disease Ontology:DOID:2998); primary ovarian insufficiency (Disease Ontology:DOID:5426); gastroesophageal reflux disease (Disease Ontology:DOID:8534); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:22061); (R-MMU-6804759)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10227293;10227294;11932750;14729569;18806757;21750661;22197488;30084848;31219806;32758484;34428180;36856110;9703973;9774969", "class_list": "", "function": "Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Binds to an upstream regulatory region of the DSG1 gene and promotes transcription (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB]; This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88897;O88899;O89097;Q8C826;Q9QWY9;Q9QWZ0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0050699 WW domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0000785 chromatin", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88898-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0L9-1", "uniprot_id": [ { "id": "MUC24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0L9", "type": "external" } ], "mass": 21059.0, "length": 197, "protein_name": "Sialomucin core protein 24", "gene_name": "Cd164", "organism": "Mouse", "refseq_name": "sialomucin core protein 24 precursor", "refseq_ac": [ { "id": "NP_058594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058594", "type": "external" } ], "gene_names_uniprotkb": "Cd164", "gene_names_refseq": "A115; A24; Cd164; MGC-24; MSSP", "protein_names_uniprotkb": "Sialomucin core protein 24; Endolyn; MGC-24v; MGC-24; MUC-24; Multi-glycosylated core protein 24", "protein_names_refseq": "MGC-24v; MUC-24; c-Myc binding protein; endolyn; multi-glycosylated core protein 24; sialomucin core protein 24 precursor; sialomucin core protein 24", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 66 (Disease Ontology:DOID:0110587)", "pathway": " (mmu:53599)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10491205;11027692;11737267;18227060;21750661;26197441;31219806", "class_list": "", "function": "CD164 is a regulator of myoblast motility, [RefSeq, PubMed]; Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes., [UniProtKB, UniProtKB, PubMed]; The deletion of the mssp gene results in both the growth defect in the embryo and the hormonal defect in adult female mouse., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM47;Q9Z317", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007517 muscle organ development;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R0L9-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJW5-1", "uniprot_id": [ { "id": "MYOZ2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJW5", "type": "external" } ], "mass": 29762.0, "length": 264, "protein_name": "Myozenin-2", "gene_name": "Myoz2", "organism": "Mouse", "refseq_name": "myozenin-2 isoform 1", "refseq_ac": [ { "id": "NP_067478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067478", "type": "external" } ], "gene_names_uniprotkb": "Myoz2", "gene_names_refseq": "1110012I24Rik; Fatz-2; Myoz2; Myozl2", "protein_names_uniprotkb": "Myozenin-2; Calsarcin-1; FATZ-related protein 2", "protein_names_refseq": "FATZ-related protein 2; calsarcin-1; myozenin-2 isoform 1; myozenin-like 2", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 16 (Disease Ontology:DOID:0110322)", "pathway": " (mmu:59006)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11114196;15543153;17242355;17341303;21183079;21750661;24129315;36288343", "class_list": "", "function": "Calsarcin-1 negatively modulates the functions of calcineurin., [RefSeq, PubMed]; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis., [UniProtKB, PubMed]; Study defined proximal promoter region of calsarcin-1 (CS-1)& calsarcin-2 (CS-2)genes; data suggest NF-kappaB is required for transcription of CS-1 gene, but not CS-2 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051373 FATZ binding;GO:0031433 telethonin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030018 Z disc", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043503 skeletal muscle fiber adaptation;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0045214 sarcomere organization;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JJW5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70468-1", "uniprot_id": [ { "id": "MYPC3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70468", "type": "external" } ], "mass": 140632.0, "length": 1270, "protein_name": "Myosin-binding protein C, cardiac-type", "gene_name": "Mybpc3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mybpc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform; Cardiac MyBP-C", "protein_names_refseq": "", "tax_id": 10090, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); dilated cardiomyopathy 1MM (Disease Ontology:DOID:0081158); hypertrophic cardiomyopathy 4 (Disease Ontology:DOID:0110310); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:17868); (R-MMU-390522)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10532952;19541641;21183079;21750661;24129315;34418053;36288343;37507081", "class_list": "", "function": "Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88997", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030017 sarcomere;GO:0031430 M band;GO:0030016 myofibril;GO:0031672 A band", "go_biological_process": "GO:0031034 myosin filament assembly;GO:0006936 muscle contraction;GO:0007155 cell adhesion;GO:0008016 regulation of heart contraction;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70468-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4E4-1", "uniprot_id": [ { "id": "MYOZ3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4E4", "type": "external" } ], "mass": 26982.0, "length": 245, "protein_name": "Myozenin-3", "gene_name": "Myoz3", "organism": "Mouse", "refseq_name": "myozenin-3", "refseq_ac": [ { "id": "NP_579941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579941", "type": "external" } ], "gene_names_uniprotkb": "Myoz3", "gene_names_refseq": "4833419K08Rik; Fatz-3; Myoz3", "protein_names_uniprotkb": "Myozenin-3; Calsarcin-3; FATZ-related protein 3", "protein_names_refseq": "FATZ-related protein 3; calsarcin-3; myozenin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:170947)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11842093;21183079;21750661", "class_list": "", "function": "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins., [RefSeq, PubMed]; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051373 FATZ binding;GO:0031433 telethonin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030018 Z disc", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R4E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK81-1", "uniprot_id": [ { "id": "MYG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK81", "type": "external" } ], "mass": 42723.0, "length": 380, "protein_name": "MYG1 exonuclease", "gene_name": "Myg1", "organism": "Mouse", "refseq_name": "MYG1 exonuclease precursor", "refseq_ac": [ { "id": "NP_068359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068359", "type": "external" } ], "gene_names_uniprotkb": "Myg1", "gene_names_refseq": "0610023A07Rik; 2810433J21Rik; 5830429P19Rik; Gamm1; Myg1", "protein_names_uniprotkb": "MYG1 exonuclease; 3.1.-.-; Protein Gamm1", "protein_names_refseq": "MYG1 exonuclease precursor; MYG1 exonuclease; UPF0160 protein MYG1, mitochondrial; protein Gamm1", "tax_id": 10090, "disease": "vitiligo (Disease Ontology:DOID:12306)", "pathway": " (mmu:60315)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19014353;19818808;21750661;23806337;25428506;31081026;34428180;37507081", "class_list": "", "function": "3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (PubMed:31081026)., [UniProtKB, PubMed]; Analysis of the widely conserved dually localized protein Myg1 shows that it has a role as a 3'-5' RNA exonuclease, [RefSeq, PubMed]; Myg1 knockout decreases several behavioural differences (anxiety- and stress-related responses) between male and female animals, indicating that Myg1 contributes to the expression of sex-dependent behavioural differences in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYX0", "ec_number_list": [], "go_molecular_function": "GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000959 mitochondrial RNA metabolic process;GO:0006397 mRNA processing;GO:0006364 rRNA processing;GO:0035641 locomotory exploration behavior", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JK81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01108-1", "uniprot_id": [ { "id": "MYC_MOUSE", "url": "https://www.uniprot.org/uniprot/P01108", "type": "external" } ], "mass": 50678.0, "length": 454, "protein_name": "Myc proto-oncogene protein", "gene_name": "Myc", "organism": "Mouse", "refseq_name": "myc proto-oncogene protein isoform b", "refseq_ac": [ { "id": "NP_001170823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170823", "type": "external" } ], "gene_names_uniprotkb": "Myc", "gene_names_refseq": "Myc2; Myc; Niard; Nird; bHLHe39", "protein_names_uniprotkb": "Myc proto-oncogene protein; Proto-oncogene c-Myc; Transcription factor p64", "protein_names_refseq": "c-myc proto-oncogene; myc proto-oncogene protein isoform b; myelocytomatosis oncogene; transcription factor p64", "tax_id": 10090, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); leiomyoma (Disease Ontology:DOID:127); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); hyperparathyroidism (Disease Ontology:DOID:13543); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); demyelinating disease (Disease Ontology:DOID:3213); rhabdoid cancer (Disease Ontology:DOID:3672); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pancreatic carcinoma (Disease Ontology:DOID:4905); liver cirrhosis (Disease Ontology:DOID:5082); prolactinoma (Disease Ontology:DOID:5394); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17869); (R-MMU-5689880); (R-MMU-8866911)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "12391307;1628829;16904174;18438430;21750661;22328504;22510880;23806337;27482104;28499244;31005419;3277717;38975812;40128797;6321164;6412145;6462227;8521822", "class_list": "glycogene", "function": "The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]., [RefSeq]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (PubMed:31005419). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 35, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WSQ0;B2RSN1;F6PX41;F8WID3;P70247;Q3UM70;Q61422", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005819 spindle", "go_biological_process": "GO:0043279 response to alkaloid;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:2001171 positive regulation of ATP biosynthetic process;GO:0060252 positive regulation of glial cell proliferation;GO:0032204 regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P01108-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70670-1", "uniprot_id": [ { "id": "NACAM_MOUSE", "url": "https://www.uniprot.org/uniprot/P70670", "type": "external" } ], "mass": 220499.0, "length": 2187, "protein_name": "Nascent polypeptide-associated complex subunit alpha, muscle-specific form", "gene_name": "Naca", "organism": "Mouse", "refseq_name": "nascent polypeptide-associated complex subunit alpha isoform b", "refseq_ac": [ { "id": "NP_038636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038636", "type": "external" } ], "gene_names_uniprotkb": "Naca; Gm1878", "gene_names_refseq": "Gm1878; Naca; mKIAA0363; skNAC", "protein_names_uniprotkb": "Nascent polypeptide-associated complex subunit alpha, muscle-specific form; Alpha-NAC, muscle-specific form; skNAC", "protein_names_refseq": "alpha-NAC, muscle-specific form; alpha-NAC/1.9.2; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha isoform b; nascent polypeptide-associated complex subunit alpha, muscle-specific form", "tax_id": 10090, "disease": "", "pathway": " (mmu:17938)", "pathway_count": 1, "publication_count": 39, "publication_id_list": "10.3389/fragi.2021.757801;10224091;12011100;15005626;15299025;15345747;15831452;17242355;19144319;21071677;21183079;23662692;23806337;24129315;25428506;26192747;28011936;29413898;29499397;30016717;30084848;31616917;32782141;32848054;34428180;35469018;35820727;35822049;36219563;36288343;36852467;37453647;37507081;39927985;40885482;8698236;9488445;9488446;9877153", "class_list": "", "function": "Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres., [UniProtKB, PubMed, PubMed, PubMed]; Data show that reduction of alpha chain of nascent polypeptide associated complex (alphaNAC) levels decreased basal expression of Low density lipoprotein receptor-Related Protein 6 (Lrp6) by 30%., [RefSeq, PubMed]; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The data suggest that skNAC and Smyd1 might be major players in the processes of myofibrillogenesis and sarcomerogenesis, probably specifically at later stages., [RefSeq, PubMed]; The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-alpha., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 51, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 51, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 51, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 60, "binding_glycan_count": 0, "secondary_ac_list": "E9QMB1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0051082 unfolded protein binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006612 protein targeting to membrane;GO:0051451 myoblast migration;GO:1905551 negative regulation of protein localization to endoplasmic reticulum;GO:0043403 skeletal muscle tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 9.2, "record_id": "P70670-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1EG27-1", "uniprot_id": [ { "id": "MYO3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1EG27", "type": "external" } ], "mass": 148099.0, "length": 1305, "protein_name": "Myosin-IIIb", "gene_name": "Myo3b", "organism": "Mouse", "refseq_name": "myosin-IIIb", "refseq_ac": [ { "id": "NP_796350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796350", "type": "external" } ], "gene_names_uniprotkb": "Myo3b", "gene_names_refseq": "A430065P19Rik; Myo3b", "protein_names_uniprotkb": "Myosin-IIIb; 2.7.11.1", "protein_names_refseq": "myosin IIIB1; myosin IIIB2; myosin-IIIb", "tax_id": 10090, "disease": "", "pathway": " (mmu:329421)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22264607;26754646;26926603;30084848;34428180", "class_list": "", "function": "Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607)., [UniProtKB, PubMed, PubMed, UniProtKB]; Results uncover the critical role that class III myosins play redundantly in hair-bundle morphogenesis, [RefSeq, PubMed]; When myosin IIIB (MYO3B) is coexpressed with espin-1 (ESPN1), MYO3B targets and carries ESPN1 to COS7 cell filopodia tips. This tip localization is lost when the ESPN1 C terminus actin-binding site is removed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR19;Q1EG26", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0000146 microfilament motor activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0001917 photoreceptor inner segment;GO:0032433 filopodium tip;GO:0001750 photoreceptor outer segment;GO:0032426 stereocilium tip", "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0007601 visual perception;GO:0046777 protein autophosphorylation;GO:0007605 sensory perception of sound;GO:0018107 peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q1EG27-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU14-1", "uniprot_id": [ { "id": "MYO16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU14", "type": "external" } ], "mass": 211383.0, "length": 1919, "protein_name": "Unconventional myosin-XVI", "gene_name": "Myo16", "organism": "Mouse", "refseq_name": "unconventional myosin-XVI", "refseq_ac": [ { "id": "NP_001306080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001306080", "type": "external" } ], "gene_names_uniprotkb": "Myo16; Kiaa0865; Nyap3", "gene_names_refseq": "C230040D10Rik; Gm1105; Myo16; NYAP3; mKIAA0865", "protein_names_uniprotkb": "Unconventional myosin-XVI; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; Unconventional myosin-16", "protein_names_refseq": "neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 3; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; unconventional myosin-16; unconventional myosin-XVI", "tax_id": 10090, "disease": "", "pathway": " (mmu:244281)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;18034455;21750661;21946561", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development (By similarity). Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RX94;E1CB68;Q6GQW7;Q8BUV4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016459 myosin complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0048812 neuron projection morphogenesis;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5DU14-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60974-1", "uniprot_id": [ { "id": "NCOR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60974", "type": "external" } ], "mass": 270642.0, "length": 2453, "protein_name": "Nuclear receptor corepressor 1", "gene_name": "Ncor1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncor1; Rxrip13", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor corepressor 1; N-CoR1; N-CoR; RIP13; Retinoid X receptor-interacting protein 13", "protein_names_refseq": "", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); polycystic ovary syndrome (Disease Ontology:DOID:11612); Huntington's disease (Disease Ontology:DOID:12858); hypothyroidism (Disease Ontology:DOID:1459); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (mmu:20185); (R-MMU-2173795); (R-MMU-350054); (R-MMU-381340); (R-MMU-383280); (R-MMU-400206); (R-MMU-9029569); (R-MMU-9623433); (R-MMU-9707564); (R-MMU-9841922)", "pathway_count": 10, "publication_count": 42, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10984530;11533236;12130660;17205979;17242355;19037247;19078967;19131326;19144319;19458039;19786558;21183079;21499262;21606357;21750661;22517741;22645316;23806337;24794873;27864380;29237092;30059200;31219806;32782141;32848054;34428180;34678516;35822049;36852467;38861834;40021952;40885482;40997131;7566114;7760852;8961273;9139820;9405624;9637679;9702189", "class_list": "", "function": "Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (PubMed:24794873). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q60812", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002155 regulation of thyroid hormone receptor signaling pathway;GO:0060318 definitive erythrocyte differentiation;GO:0045922 negative regulation of fatty acid metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "Q60974-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGB6-1", "uniprot_id": [ { "id": "NAA50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGB6", "type": "external" } ], "mass": 19414.0, "length": 169, "protein_name": "N-alpha-acetyltransferase 50", "gene_name": "Naa50", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 50 isoform 2", "refseq_ac": [ { "id": "NP_001334168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334168", "type": "external" } ], "gene_names_uniprotkb": "Naa50; Mak3; Nat13", "gene_names_refseq": "2600005K24Rik; 2810441M03Rik; Mak3p; Mak3; Naa50; Nat13; Nat5; San", "protein_names_uniprotkb": "N-alpha-acetyltransferase 50; 2.3.1.-; 2.3.1.258; N-acetyltransferase NAT13; N-epsilon-acetyltransferase 50; NatE catalytic subunit", "protein_names_refseq": "Mak3 homolog; Mak3p homolog; N-acetyltransferase 13; N-acetyltransferase NAT13; N-alpha-acetyltransferase 50 isoform 2; N-epsilon-acetyltransferase 50; Nalpha acetyltransferase 50; natE catalytic subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:72117)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16484612;23806337;31219806", "class_list": "", "function": "N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). Autoacetylates in vivo (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (By similarity). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (By similarity). Does not influence the acetyltransferase activity of NAA10 (By similarity). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (By similarity). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH79;Q3TK59;Q7TML2;Q80VE3;Q9D0Q8", "ec_number_list": [ { "id": "2.3.1.258", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.258", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.256", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.256", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PGB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C170-1", "uniprot_id": [ { "id": "MYO9A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C170", "type": "external" } ], "mass": 292119.0, "length": 2542, "protein_name": "Unconventional myosin-IXa", "gene_name": "Myo9a", "organism": "Mouse", "refseq_name": "unconventional myosin-IXa isoform X14", "refseq_ac": [ { "id": "XP_006511283", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006511283", "type": "external" } ], "gene_names_uniprotkb": "Myo9a; Myr7", "gene_names_refseq": "4732465J09Rik; C130068I12Rik; C230003M11; Myo9a", "protein_names_uniprotkb": "Unconventional myosin-IXa; Unconventional myosin-9a", "protein_names_refseq": "unconventional myosin-IXa isoform X14", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); obstructive hydrocephalus (Disease Ontology:DOID:14159); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (mmu:270163); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013424)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10409426;19828736;21183079;21750661;22645316;25428506;27259756;30084848;31219806;32848054;34428180", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRT5;Q4VBD3;Q80Y92;Q8C0U0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0016020 membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0034329 cell junction assembly;GO:0035556 intracellular signal transduction;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0150011 regulation of neuron projection arborization;GO:0099084 postsynaptic specialization organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8C170-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K596-1", "uniprot_id": [ { "id": "NAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K596", "type": "external" } ], "mass": 100711.0, "length": 921, "protein_name": "Sodium/calcium exchanger 2", "gene_name": "Slc8a2", "organism": "Mouse", "refseq_name": "sodium/calcium exchanger 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001334490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334490", "type": "external" } ], "gene_names_uniprotkb": "Slc8a2; Ncx2", "gene_names_refseq": "Ncx2; Slc8a2", "protein_names_uniprotkb": "Sodium/calcium exchanger 2; Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 2; sodium/calcium exchanger 2 isoform 2 precursor; sodium/calcium exchanger 2; solute carrier family 8 member 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:110891); (R-MMU-418359); (R-MMU-425561); (R-MMU-5578775)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12581871;12818181;21183079;23506867;25498502;29274751;33300544;34428180;36077454", "class_list": "", "function": "Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:12818181). Contributes to cellular Ca(2+) homeostasis in excitable cells (PubMed:12818181). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:12818181). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (PubMed:25498502)., [UniProtKB, PubMed]; NCX2 and NCX3 protein and mRNA levels are relatively reduced in hippocampal CA1 of APP23 and APP-KI mice. Likewise, NCX2(+/-) or NCX3(+/-) mice exhibited impaired hippocampal LTP and memory-related behaviors. Moreover, relative to controls, calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation significantly decreased in NCX2(+/-) mouse hippocampus but increased in hippocampus of NCX3(+/-) mice., [RefSeq, PubMed]; Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage? Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q68EG0;Q8R504", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015085 calcium ion transmembrane transporter activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0002931 response to ischemia;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K596-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY06-1", "uniprot_id": [ { "id": "MYO9B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY06", "type": "external" } ], "mass": 238834.0, "length": 2114, "protein_name": "Unconventional myosin-IXb", "gene_name": "Myo9b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myo9b; Myr5", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-IXb; Unconventional myosin-9b", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17925); (R-MMU-2029482); (R-MMU-8980692); (R-MMU-8985586); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9035034)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "10580159;19131326;19144319;21183079;21750661;31219806;34428180;36210013", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY07;Q9QY08;Q9QY09", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005938 cell cortex", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007266 Rho protein signal transduction;GO:0030048 actin filament-based movement;GO:0033275 actin-myosin filament sliding;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QY06-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEC0-1", "uniprot_id": [ { "id": "NUP88_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEC0", "type": "external" } ], "mass": 84938.0, "length": 753, "protein_name": "Nuclear pore complex protein Nup88", "gene_name": "Nup88", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup88 isoform 2", "refseq_ac": [ { "id": "NP_001076800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076800", "type": "external" } ], "gene_names_uniprotkb": "Nup88", "gene_names_refseq": "Nup84; Nup88; Prei2", "protein_names_uniprotkb": "Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88", "protein_names_refseq": "88 kDa nucleoporin; nuclear pore complex protein Nup88 isoform 2; nuclear pore complex protein Nup88; preimplantation protein 2", "tax_id": 10090, "disease": "fetal akinesia deformation sequence syndrome 4 (Disease Ontology:DOID:0111379)", "pathway": " (mmu:19069); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 12, "publication_id_list": "17242355;18606815;18621024;19144319;21183079;21750661;29187734;31599954;34428180;34678516;34887587;39627609", "class_list": "", "function": "Component of nuclear pore complex., [UniProtKB, UniProtKB]; Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes., [RefSeq, PubMed]; Nup88 regulates the activity of NF-kappaB at the level of nucleocytoplasmic transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Z13;Q8K090", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006606 protein import into nucleus;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CEC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99L02-1", "uniprot_id": [ { "id": "PGR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99L02", "type": "external" } ], "mass": 27723.0, "length": 253, "protein_name": "PAXIP1-associated glutamate-rich protein 1A", "gene_name": "Gm42742; Pagr1a", "organism": "Mouse", "refseq_name": "PAXIP1-associated glutamate-rich protein 1A", "refseq_ac": [ { "id": "NP_084516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084516", "type": "external" } ], "gene_names_uniprotkb": "Gm42742; Pagr1a; Pa1; Pagr", "gene_names_refseq": "2900092E17Rik; PA1; PAGR1; Pagr1a", "protein_names_uniprotkb": "PAXIP1-associated glutamate-rich protein 1A; PAXIP1-associated protein 1; PTIP-associated protein 1", "protein_names_refseq": "PAXIP1-associated glutamate-rich protein 1A; PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated 1; PTIP-associated protein 1", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:67278); (R-MMU-9772755); (R-MMU-9818564)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15345747;17500065;19124460;21750661;24633704;26744420;32601106", "class_list": "", "function": "A PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR, [RefSeq, PubMed]; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (PubMed:26744420). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (PubMed:26744420). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development (PubMed:24633704)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPbeta and C/EBPdelta. Publication Status: Online-Only, [RefSeq, PubMed]; PA1 (also known as C16orf53 in human and 2900092E17Rik in mouse) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex., [RefSeq, PubMed]; Subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0060717 chorion development;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99L02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29341-1", "uniprot_id": [ { "id": "PABP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P29341", "type": "external" } ], "mass": 70671.0, "length": 636, "protein_name": "Polyadenylate-binding protein 1", "gene_name": "Pabpc1", "organism": "Mouse", "refseq_name": "polyadenylate-binding protein 1", "refseq_ac": [ { "id": "NP_032800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032800", "type": "external" } ], "gene_names_uniprotkb": "Pabpc1; Pabp1", "gene_names_refseq": "PABP; Pabp1; PabpI; Pabpc1; Pabpl1; ePAB", "protein_names_uniprotkb": "Polyadenylate-binding protein 1; PABP-1; Poly(A)-binding protein 1", "protein_names_refseq": "PABP-1; poly(A)-binding protein 1; polyadenylate-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18458); (R-MMU-156827); (R-MMU-429947); (R-MMU-450408); (R-MMU-72649); (R-MMU-975956); (R-MMU-975957)", "pathway_count": 7, "publication_count": 36, "publication_id_list": "10076007;15240697;15314026;1630930;17927953;19020299;20484733;21750661;21952136;22645316;22872234;24129315;25428506;25428507;25605945;26495903;29125738;30084848;30779550;32782141;32848054;33300544;34428180;34678516;34887587;35511136;35820727;36001654;36210013;36288343;36852467;37453647;37828378;39927985;40021952;40885482", "class_list": "", "function": "Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability., [UniProtKB, UniProtKB]; De novo variants in the PABP domain of PABPC1 lead to developmental delay., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q99L36", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030425 dendrite", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P29341-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47239-1", "uniprot_id": [ { "id": "PAX7_MOUSE", "url": "https://www.uniprot.org/uniprot/P47239", "type": "external" } ], "mass": 54939.0, "length": 503, "protein_name": "Paired box protein Pax-7", "gene_name": "Pax7", "organism": "Mouse", "refseq_name": "paired box protein Pax-7", "refseq_ac": [ { "id": "NP_035169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035169", "type": "external" } ], "gene_names_uniprotkb": "Pax7; Pax-7", "gene_names_refseq": "Pax-7; Pax7", "protein_names_uniprotkb": "Paired box protein Pax-7", "protein_names_refseq": "paired box gene 7; paired box protein Pax-7; paired box transcription factor PAX7", "tax_id": 10090, "disease": "congenital myopathy 19 (Disease Ontology:DOID:0081351); prostate cancer (Disease Ontology:DOID:10283); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051)", "pathway": " (mmu:18509)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11030621;1982921;21750661;22862948;34059674", "class_list": "", "function": "Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ES16", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014816 skeletal muscle satellite cell differentiation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47239-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35973-1", "uniprot_id": [ { "id": "PER1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35973", "type": "external" } ], "mass": 136373.0, "length": 1291, "protein_name": "Period circadian protein homolog 1", "gene_name": "Per1", "organism": "Mouse", "refseq_name": "period circadian protein homolog 1", "refseq_ac": [ { "id": "NP_001152839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152839", "type": "external" } ], "gene_names_uniprotkb": "Per1; Per; Rigui", "gene_names_refseq": "Hftm; Per1; Per; m-rigui; mPer1", "protein_names_uniprotkb": "Period circadian protein homolog 1; Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; mPER1", "protein_names_refseq": "circadian clock protein PERIOD 1; circadian pacemaker protein Rigui; period circadian protein homolog 1; period homolog 1", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:18626); (R-MMU-9932298)", "pathway_count": 2, "publication_count": 44, "publication_id_list": "10231394;10428031;10521578;10848614;10857746;11395012;11591712;11779462;11865049;11875063;14672706;14701732;15148313;15888647;16478995;16717091;16750171;16790549;19414593;20484733;21183079;21712997;21750661;21930935;22069332;22331899;22966205;23213472;23303907;23916625;24154698;24378737;24603368;24610784;24837677;25428506;30084848;30779550;34428180;37828378;9323128;9333243;9427249;9856465", "class_list": "", "function": "This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1ASX0", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "O35973-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTQ0-1", "uniprot_id": [ { "id": "PCGF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTQ0", "type": "external" } ], "mass": 28046.0, "length": 241, "protein_name": "Polycomb group RING finger protein 3", "gene_name": "PcgF3; Pcgf3", "organism": "Mouse", "refseq_name": "polycomb group RING finger protein 3 isoform 1", "refseq_ac": [ { "id": "NP_766304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766304", "type": "external" } ], "gene_names_uniprotkb": "PcgF3; Pcgf3; Rnf3a; Rnf3", "gene_names_refseq": "2310035N15Rik; D630042K08Rik; DONG1; E430039C14; Pcgf3; RNF3A; Rnf3", "protein_names_uniprotkb": "Polycomb group RING finger protein 3; RING finger protein 3A", "protein_names_refseq": "RING finger protein 3A; polycomb group RING finger protein 3 isoform 1; polycomb group RING finger protein 3; ring finger protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69587)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28596365;31219806", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZT0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140862 histone H2AK119 ubiquitin ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYK5-1", "uniprot_id": [ { "id": "PHAR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYK5", "type": "external" } ], "mass": 62652.0, "length": 558, "protein_name": "Phosphatase and actin regulator 3", "gene_name": "Phactr3", "organism": "Mouse", "refseq_name": "phosphatase and actin regulator 3 isoform 2", "refseq_ac": [ { "id": "NP_001007155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007155", "type": "external" } ], "gene_names_uniprotkb": "Phactr3; Scapin1", "gene_names_refseq": "1500003N10Rik; 4930415A02Rik; H17739; Phactr3; Scapin1; Scapinin; mKIAA4224", "protein_names_uniprotkb": "Phosphatase and actin regulator 3; Scaffold-associated PP1-inhibiting protein; Scapinin", "protein_names_refseq": "phosphatase and actin regulator 3 isoform 2; scaffold-associated PP1-inhibiting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74189)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15107502;16974080;18295233;21183079;21750661;22766235;32423795", "class_list": "", "function": "Expression analysis in the mouse revealed a tissue-specific complex transcription pattern in the brain and a specific pattern was observed during prenatal development, [RefSeq, PubMed]; Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain., [RefSeq, PubMed]; Phactr3 exon 1C splice variant is potentially strain specific regulated, leading to the expression of only one allele of the reciprocal crosses., [RefSeq, PubMed]; This study demonistrated that Phactr1 appeared to be expressed in post-mitotic neurons in developmental brain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYS8;Q8C058;Q9DB87", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BYK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N2-1", "uniprot_id": [ { "id": "ORC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1N2", "type": "external" } ], "mass": 95103.0, "length": 840, "protein_name": "Origin recognition complex subunit 1", "gene_name": "Orc1", "organism": "Mouse", "refseq_name": "origin recognition complex subunit 1", "refseq_ac": [ { "id": "NP_035145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035145", "type": "external" } ], "gene_names_uniprotkb": "Orc1; Orc1l", "gene_names_refseq": "MmORC1; Orc1l; Orc1", "protein_names_uniprotkb": "Origin recognition complex subunit 1", "protein_names_refseq": "origin recognition complex subunit 1", "tax_id": 10090, "disease": "Meier-Gorlin syndrome 1 (Disease Ontology:DOID:0080512)", "pathway": " (mmu:18392); (R-MMU-176187); (R-MMU-68616); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "15634681;20173027;21183079;22398447;29967292;31219806;34428180;38009275;9862484", "class_list": "", "function": "Clearance of beta-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes., [RefSeq, PubMed]; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)., [UniProtKB]; Mouse Orc1, Orc2, and Orc3 each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation, [RefSeq, PubMed]; ORC1 in mice is essential for mitotic cell divisions but dispensable for endoreduplication., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A8R3", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005664 nuclear origin of replication recognition complex;GO:0000781 chromosome, telomeric region;GO:0000808 origin recognition complex", "go_biological_process": "GO:0006260 DNA replication;GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0006270 DNA replication initiation;GO:0070318 positive regulation of G0 to G1 transition;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z1N2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53612-1", "uniprot_id": [ { "id": "PGTB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P53612", "type": "external" } ], "mass": 37803.0, "length": 339, "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "Rabggtb", "organism": "Mouse", "refseq_name": "geranylgeranyl transferase type-2 subunit beta isoform 1", "refseq_ac": [ { "id": "NP_035361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035361", "type": "external" } ], "gene_names_uniprotkb": "Rabggtb", "gene_names_refseq": "Rabggtb", "protein_names_uniprotkb": "Geranylgeranyl transferase type-2 subunit beta; 2.5.1.60; GGTase-II-beta; Geranylgeranyl transferase type II subunit beta; Rab GG transferase beta; Rab GGTase beta; Rab geranyl-geranyltransferase subunit beta; Rab geranylgeranyltransferase subunit beta; Type II protein geranyl-geranyltransferase subunit beta", "protein_names_refseq": "GGTase-II-beta; RAB geranylgeranyltransferase, beta subunit; geranylgeranyl transferase type II subunit beta; geranylgeranyl transferase type-2 subunit beta isoform 1; geranylgeranyl transferase type-2 subunit beta; rab GG transferase beta; rab GGTase beta; rab geranyl-geranyltransferase subunit beta; type II protein geranyl-geranyltransferase subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:19352); (R-MMU-6803205); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18161010;21520375;21750661;34428180;7544156;9031634", "class_list": "", "function": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; The function of chodl was investigated by searching for its protein interaction partners., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTE6", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" } ], "go_molecular_function": "GO:0004663 Rab geranylgeranyltransferase activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0019840 isoprenoid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0018344 protein geranylgeranylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53612-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBX2-1", "uniprot_id": [ { "id": "PHLP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBX2", "type": "external" } ], "mass": 34407.0, "length": 301, "protein_name": "Phosducin-like protein", "gene_name": "Pdcl", "organism": "Mouse", "refseq_name": "phosducin-like protein", "refseq_ac": [ { "id": "NP_080452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080452", "type": "external" } ], "gene_names_uniprotkb": "Pdcl; PhLP1", "gene_names_refseq": "1200011E13Rik; Pdcl; PhLP1", "protein_names_uniprotkb": "Phosducin-like protein; PHLP", "protein_names_refseq": "PHLP; phosducin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67466); (R-MMU-6814122)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12015208;12466282;15889144;17242355;21183079;21750661;23637185;23888055;25659125;29290584;34428180;9139665", "class_list": "", "function": "Evidence of a generic mechanism, whereby the splicing of the PhLP gene could potentially and efficiently regulate the cellular levels of heterotrimeric G proteins., [RefSeq, PubMed]; Findings reveal a common mechanism of Gbetagamma and RGS9-Gbeta5 assembly in rods and cones, highlighting the importance of PhLP1 and CCT-mediated Gbeta complex formation in G protein signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers (PubMed:23637185). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584)., [UniProtKB, PubMed, PubMed]; N-glycosylated phosducin-like protein long (PhLP(L)) is expressed in all structures of the central nervous system and regulates opioid receptor function in the brain., [RefSeq, PubMed]; Pdcl has been implicated as a positive regulator of Hedgehog signaling that may control the trafficking of signaling receptors to primary cilia. Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002. PMID: 29401421], [RefSeq, PubMed]; Physiological control of G-protein regulation by PhLP seems to involve phosphorylation by CK2 and alternative splicing of the regulator, [RefSeq, PubMed]; These data are consistent with the hypothesis that PhLP is a widely expressed modulator of Gbetagamma function., [RefSeq, PubMed]; These results suggest a mechanism for Gbetagamma assembly in which PhLP stabilizes the nascent Gbeta polypeptide until Ggamma can associate, resulting in membrane binding of Gbetagamma and release of PhLP to catalyze another round of assembly., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKI0", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007601 visual perception;GO:0006457 protein folding;GO:0030030 cell projection organization;GO:1902605 heterotrimeric G-protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DBX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Y8-1", "uniprot_id": [ { "id": "PLPHP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2Y8", "type": "external" } ], "mass": 30049.0, "length": 274, "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "Plpbp", "organism": "Mouse", "refseq_name": "pyridoxal phosphate homeostasis protein isoform a", "refseq_ac": [ { "id": "NP_473398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473398", "type": "external" } ], "gene_names_uniprotkb": "Plpbp; Prosc", "gene_names_refseq": "1700024N20Rik; 2200002F22Rik; Plpbp; Prosc", "protein_names_uniprotkb": "Pyridoxal phosphate homeostasis protein; PLP homeostasis protein; Proline synthase co-transcribed bacterial homolog protein; Pyridoxal phosphate-binding protein", "protein_names_refseq": "PLP homeostasis protein; proline synthase co-transcribed bacterial homolog protein; proline synthetase co-transcribed bacterial homolog protein; pyridoxal phosphate homeostasis protein isoform a; pyridoxal phosphate homeostasis protein", "tax_id": 10090, "disease": "early-onset vitamin B6-dependent epilepsy 1 (Disease Ontology:DOID:0080769)", "pathway": " (mmu:114863)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10496079;18034455;21750661;23806337;37507081", "class_list": "", "function": "Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042816 vitamin B6 metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2Y8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0K1-1", "uniprot_id": [ { "id": "PEX13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0K1", "type": "external" } ], "mass": 44610.0, "length": 405, "protein_name": "Peroxisomal membrane protein PEX13", "gene_name": "Pex13", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein PEX13", "refseq_ac": [ { "id": "NP_076140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076140", "type": "external" } ], "gene_names_uniprotkb": "Pex13", "gene_names_refseq": "2610008O20Rik; Pex13", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX13; Peroxin-13", "protein_names_refseq": "peroxin-13; peroxisomal membrane protein PEX13", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 11A (Disease Ontology:DOID:0080485); Peroxisome biogenesis disorder 11B (Disease Ontology:DOID:0081439); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (mmu:72129); (R-MMU-8866654); (R-MMU-9033241); (R-MMU-9603798)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "11829486;12897163;17242355;21750661;25428506;29187321;30084848;31219806;32565019;34428180;34517131", "class_list": "", "function": "An increasing reactive gliosis in the PEX13 mutant brain started at E14.5 in association with the pathology, [RefSeq, PubMed]; Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Gene structure, tissue expression, and localization of the protein to peroxisomes, [RefSeq, PubMed]; Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis., [RefSeq, PubMed]; PEX13 is required for thermogenesis of white adipose tissue in cold-exposed mice., [RefSeq, PubMed]; Pex13 has a role in peroxisome biogenesis and its disruption in mice causes a Zellweger syndrome phenotype, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5T1;Q8CCJ5;Q8CCW5;Q99MM2;Q9EPK1", "ec_number_list": [], "go_molecular_function": "GO:0000268 peroxisome targeting sequence binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0043335 protein unfolding;GO:0001967 suckling behavior;GO:0007626 locomotory behavior;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D0K1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0E2-1", "uniprot_id": [ { "id": "PLOD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0E2", "type": "external" } ], "mass": 83595.0, "length": 728, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "gene_name": "Plod1", "organism": "Mouse", "refseq_name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor", "refseq_ac": [ { "id": "NP_035252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035252", "type": "external" } ], "gene_names_uniprotkb": "Plod1; Plod", "gene_names_refseq": "2410042F05Rik; Lh1; Plod1; Plod", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; 1.14.11.4; LH1; Lysyl hydroxylase 1", "protein_names_refseq": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome kyphoscoliotic type 1 (Disease Ontology:DOID:0080734); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:18822); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10429951;11801660;19349973;21750661;25428506;26740625;27119146;30084848;30779550;30899004;31219806;33649389;34428180;34646388;35820727;36210013;36721170;37828378;37936548", "class_list": "glycogene", "function": "Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm. Publication Status: Online-Only, [RefSeq, PubMed]; Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network. Publication Status: Online-Only, [RefSeq, PubMed]; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (PubMed:27119146). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (PubMed:27119146)., [UniProtKB, PubMed, UniProtKB]; SIRT6 deficiency causes ovarian hypoplasia by affecting Plod1-related collagen formation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" }, { "id": "2.4.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50", "type": "external" }, { "id": "2.4.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0042277 peptide binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:1902494 catalytic complex", "go_biological_process": "GO:0001666 response to hypoxia;GO:0008544 epidermis development;GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9R0E2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53811-1", "uniprot_id": [ { "id": "PIPNB_MOUSE", "url": "https://www.uniprot.org/uniprot/P53811", "type": "external" } ], "mass": 31487.0, "length": 271, "protein_name": "Phosphatidylinositol transfer protein beta isoform", "gene_name": "Pitpnb", "organism": "Mouse", "refseq_name": "phosphatidylinositol transfer protein beta isoform isoform 3", "refseq_ac": [ { "id": "NP_001288573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288573", "type": "external" } ], "gene_names_uniprotkb": "Pitpnb", "gene_names_refseq": "PI-TP-beta; Pitpnb", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein beta isoform; PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta", "protein_names_refseq": "Pitp beta; phosphatidylinositol transfer protein beta isoform isoform 3; phosphotidylinositol transfer protein, beta; ptdIns transfer protein beta; ptdInsTP beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:56305); (R-MMU-1483196)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11907258;11953429;15052341;15164762;17683809;30042096;39627609;7654206", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data suggest that phosphatidylinositol transfer protein (PITP) beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals., [RefSeq, PubMed]; The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine, [RefSeq, PubMed]; The PITPbeta deficiency results in catastrophic failure early in murine embryonic development, and the PITPbeta is an essential housekeeping PIPT in murine cells. Review article, [RefSeq, PubMed]; These data show that ablating PITPs in MKs indirectly dysregulates hematopoiesis in the BM by disrupting alpha-granule physiology and secretion of TGF-beta1., [RefSeq, PubMed]; This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded protein catalyzes the transfer of phospholipids (phosphatidylinositol and phosphatidylcholine) between membranes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0008525 phosphatidylcholine transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0015914 phospholipid transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53811-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U6Q4-1", "uniprot_id": [ { "id": "PI3R6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U6Q4", "type": "external" } ], "mass": 84663.0, "length": 756, "protein_name": "Phosphoinositide 3-kinase regulatory subunit 6", "gene_name": "Pik3r6", "organism": "Mouse", "refseq_name": "phosphoinositide 3-kinase regulatory subunit 6 isoform 2", "refseq_ac": [ { "id": "NP_001004435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004435", "type": "external" } ], "gene_names_uniprotkb": "Pik3r6", "gene_names_refseq": "Pik3r6; p84 PIKAP; p84; p87(PIKAP); p87PIKAP", "protein_names_uniprotkb": "Phosphoinositide 3-kinase regulatory subunit 6; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP", "protein_names_refseq": "p84 PI3K adapter protein; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein; phosphoinositide 3-kinase gamma adapter protein of 87 kDa; phosphoinositide 3-kinase regulatory subunit 6 isoform 2; phosphoinositide-3-kinase regulatory subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:104709); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1660499); (R-MMU-389357); (R-MMU-392451); (R-MMU-6811558); (R-MMU-9927354)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "15797027;16476736;18323525;19906996;33144519;38824552", "class_list": "", "function": "Ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells Erratum:[Circ Res. 2008 Jul 3;103(1):e13-4], [RefSeq, PubMed]; Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; P87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP], [RefSeq, PubMed]; PI3Kgamma inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]; Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBT5;Q3UAY4;Q8K323", "ec_number_list": [], "go_molecular_function": "GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005944 phosphatidylinositol 3-kinase complex, class IB;GO:0005942 phosphatidylinositol 3-kinase complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0045766 positive regulation of angiogenesis;GO:0043406 positive regulation of MAP kinase activity;GO:0045582 positive regulation of T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U6Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USB7-1", "uniprot_id": [ { "id": "PLCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USB7", "type": "external" } ], "mass": 122673.0, "length": 1096, "protein_name": "Inactive phospholipase C-like protein 1", "gene_name": "Plcl1", "organism": "Mouse", "refseq_name": "inactive phospholipase C-like protein 1", "refseq_ac": [ { "id": "NP_001108135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108135", "type": "external" } ], "gene_names_uniprotkb": "Plcl1", "gene_names_refseq": "C230017K02Rik; PLC-L1; PLC-L; PLCE; PLCL; PLDL1; PRIP-1; PRIP; Plcl1", "protein_names_uniprotkb": "Inactive phospholipase C-like protein 1; PLC-L1; PRIP; Phospholipase C-related but catalytically inactive protein", "protein_names_refseq": "inactive phospholipase C-like protein 1; phospholipase C, eta 2 pseudogene; phospholipase C-related but catalytically inactive protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:227120)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15306641;15468068;16854455;17301177;21183079;33743346;34428180;35820936;39456056", "class_list": "", "function": "DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of PRIP, a phosphatidylinositol 4,5-bisphosphate binding protein, attenuates PI3K/AKT signaling and suppresses tumor growth in a xenograft mouse model., [RefSeq, PubMed]; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as an inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors., [UniProtKB, PubMed, PubMed]; PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; PRIP-1 plays an important role in regulating the Ins(1,4,5)P3-mediated Ca2+ signaling by modulating type1 inositol polyphosphate 5-phosphatase activity through binding to Ins(1,4,5)P3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z0W5;Q3TSM9", "ec_number_list": [], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process;GO:0032228 regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3USB7-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJI4-1", "uniprot_id": [ { "id": "PKDCC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RJI4", "type": "external" } ], "mass": 53841.0, "length": 492, "protein_name": "Extracellular tyrosine-protein kinase PKDCC", "gene_name": "Pkdcc", "organism": "Mouse", "refseq_name": "extracellular tyrosine-protein kinase PKDCC isoform 1 precursor", "refseq_ac": [ { "id": "NP_598878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598878", "type": "external" } ], "gene_names_uniprotkb": "Pkdcc; Sgk493; Vlk", "gene_names_refseq": "Adtk1; ESTM17; MAd1; Pkdcc; Sgk493; Vlk", "protein_names_uniprotkb": "Extracellular tyrosine-protein kinase PKDCC; 2.7.10.2; Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; Sugen kinase 493; Vertebrate lonesome kinase", "protein_names_refseq": "extracellular tyrosine-protein kinase PKDCC isoform 1 precursor; extracellular tyrosine-protein kinase PKDCC; protein kinase domain-containing protein, cytoplasmic; protein kinase-like protein SgK493; sugen kinase 493; vertebrate lonesome kinase", "tax_id": 10090, "disease": "intrinsic asthma (Disease Ontology:DOID:9360)", "pathway": " (mmu:106522)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19097194;19465597;21750661;23792766;25171405;38483448", "class_list": "", "function": "A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). May also have serine/threonine protein kinase activity (PubMed:25171405). Required for longitudinal bone growth through regulation of chondrocyte differentiation (PubMed:19097194, PubMed:23792766). May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (PubMed:19465597). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These data indicate that Pkdcc encodes a protein kinase that is required for the appropriate timing of flat proliferative chondrocytes differentiation., [RefSeq, PubMed]; Vlk is a novel vertebrate-specific PK that is involved in the regulation of the rate of protein export from the Golgi, thereby playing an important role in the formation of functional stroma by mesenchymal cells., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B6F136;Q3UZD3;Q8VBZ6", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation;GO:0048286 lung alveolus development;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5RJI4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TI1-1", "uniprot_id": [ { "id": "PKHH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TI1", "type": "external" } ], "mass": 150909.0, "length": 1356, "protein_name": "Pleckstrin homology domain-containing family H member 1", "gene_name": "Plekhh1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family H member 1", "refseq_ac": [ { "id": "NP_851418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851418", "type": "external" } ], "gene_names_uniprotkb": "Plekhh1; Kiaa1200", "gene_names_refseq": "D630024D12Rik; Plekhh1; mKIAA1200", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family H member 1; PH domain-containing family H member 1", "protein_names_refseq": "PH domain-containing family H member 1; pleckstrin homology domain-containing family H member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:211945)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPN4;Q8BWF3;Q8K334;Q99JL2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80TI1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TJ7-1", "uniprot_id": [ { "id": "PHF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TJ7", "type": "external" } ], "mass": 113553.0, "length": 1023, "protein_name": "Histone lysine demethylase PHF8", "gene_name": "Phf8", "organism": "Mouse", "refseq_name": "histone lysine demethylase PHF8 isoform b", "refseq_ac": [ { "id": "NP_001106825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106825", "type": "external" } ], "gene_names_uniprotkb": "Phf8; Kiaa1111", "gene_names_refseq": "9830141C09Rik; Phf8; mKIAA1111", "protein_names_uniprotkb": "Histone lysine demethylase PHF8; 1.14.11.-; 1.14.11.65; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8", "protein_names_refseq": "[histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8; histone lysine demethylase PHF8 isoform b; histone lysine demethylase PHF8", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Siderius type (Disease Ontology:DOID:0060812); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:320595); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15112104;16199551;17242355;19144319;21183079;21750661;25428506;30084848;31219806;34418053;34428180;37477632;39323294", "class_list": "", "function": "An important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate, [RefSeq, PubMed]; Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice., [RefSeq, PubMed]; Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine beta-synthase-deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2ABU8;A2ABV0;A2ABV2;Q8BLX8;Q8BLY0;Q8BZ61;Q8CG26", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80TJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0Y0-1", "uniprot_id": [ { "id": "PP4R4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0Y0", "type": "external" } ], "mass": 99481.0, "length": 875, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 4", "gene_name": "Ppp4r4", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 4", "refseq_ac": [ { "id": "NP_083256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083256", "type": "external" } ], "gene_names_uniprotkb": "Ppp4r4; Kiaa1622; Pp4r4", "gene_names_refseq": "8430415E04Rik; Ppp4r4; mKIAA1622", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 4", "protein_names_refseq": "serine/threonine-protein phosphatase 4 regulatory subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:74521)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;22645316", "class_list": "", "function": "Putative regulatory subunit of serine/threonine-protein phosphatase 4., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKU6;Q14CI7;Q14DT1;Q69ZE5;Q9CRR0", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0019888 protein phosphatase regulator activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0008287 protein serine/threonine phosphatase complex", "go_biological_process": "GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0Y0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHE4-1", "uniprot_id": [ { "id": "PHLP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHE4", "type": "external" } ], "mass": 182367.0, "length": 1687, "protein_name": "PH domain leucine-rich repeat-containing protein phosphatase 1", "gene_name": "Phlpp1", "organism": "Mouse", "refseq_name": "PH domain leucine-rich repeat-containing protein phosphatase 1", "refseq_ac": [ { "id": "NP_598582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598582", "type": "external" } ], "gene_names_uniprotkb": "Phlpp1; Kiaa0606; Phlpp; Plekhe1; Scop", "gene_names_refseq": "Phlpp1; Phlpp; Plekhe1; SCOP; mKIAA0606", "protein_names_uniprotkb": "PH domain leucine-rich repeat-containing protein phosphatase 1; 3.1.3.16; PH domain-containing family E member 1; Pleckstrin homology domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein", "protein_names_refseq": "PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; suprachiasmatic nucleus circadian oscillatory protein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:98432); (R-MMU-199418)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15542705;17382888;20080691;20089132;21498666;31219806;34428180;36210013;38432607", "class_list": "", "function": "Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis., [RefSeq, PubMed]; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (By similarity). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylates RAF1 inhibiting its kinase activity. May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (PubMed:17382888). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (PubMed:20080691). Involved in development and function of regulatory T-cells (PubMed:21498666)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Show that PHLPP1-null mice, although displaying normal circadian rhythmicity, have a drastically impaired capacity to stabilize the circadian period after light-induced resetting, producing a large phase shift after light resetting., [RefSeq, PubMed]; To determine if hippocampus-dependent memory is influenced by SCOP in vivo, a transgenic mouse strain was generated for the inducible overexpression of SCOP in the forebrain; overexpression SCOP completely blocked memory for novel objects., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCN0;Q8QZU8;Q8R5E5;Q99KL6", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:1902532 negative regulation of intracellular signal transduction;GO:0035556 intracellular signal transduction;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CHE4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4F2-1", "uniprot_id": [ { "id": "PLPP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4F2", "type": "external" } ], "mass": 31744.0, "length": 292, "protein_name": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6", "gene_name": "Plpp6", "organism": "Mouse", "refseq_name": "polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6", "refseq_ac": [ { "id": "NP_083198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083198", "type": "external" } ], "gene_names_uniprotkb": "Plpp6", "gene_names_refseq": "4932443D16Rik; Plpp6; Ppapdc2", "protein_names_uniprotkb": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; 3.1.3.-; 3.6.1.-; 3.6.1.68; Phospholipid phosphatase 6", "protein_names_refseq": "phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; presqualene diphosphate phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74411); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17114649;17242355;21183079;34428180", "class_list": "", "function": "Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0016787 hydrolase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0042632 cholesterol homeostasis;GO:0006720 isoprenoid metabolic process;GO:0018342 protein prenylation;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D4F2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK95-1", "uniprot_id": [ { "id": "PERP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK95", "type": "external" } ], "mass": 21567.0, "length": 193, "protein_name": "p53 apoptosis effector related to PMP-22", "gene_name": "Perp", "organism": "Mouse", "refseq_name": "p53 apoptosis effector related to PMP-22", "refseq_ac": [ { "id": "NP_071315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071315", "type": "external" } ], "gene_names_uniprotkb": "Perp; Krtcap1", "gene_names_refseq": "1110017A08Rik; KCP1; KRTCAP1; PIGPC1; Perp; THW", "protein_names_uniprotkb": "p53 apoptosis effector related to PMP-22; KCP-1; Keratinocyte-associated protein 1", "protein_names_refseq": "KCP-1; keratinocyte-associated protein 1; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to Pmp22; p53 apoptosis-associated target", "tax_id": 10090, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112011)", "pathway": " (mmu:64058); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10733530;15192153;15797384;16485031;21285247;22515648;25486861;27834691;29740445;31898316", "class_list": "", "function": "A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. Erratum:[Genes Dev 2000 Jul 15;14(14):1835], [RefSeq, PubMed]; Component of intercellular desmosome junctions (PubMed:15797384). Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly (PubMed:15797384, PubMed:16485031). Thereby plays a role in barrier function of the skin against infection (PubMed:16485031). Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions (PubMed:22515648). Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis (PubMed:21285247). May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4 (PubMed:21285247). Plays a role as an effector in the TP53-dependent apoptotic pathway (PubMed:10733530). Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling (PubMed:29740445). Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8 (By similarity). May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Confirming the recessive inheritance of PERP-related erythrokeratoderma., [RefSeq, PubMed]; In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation, [RefSeq, PubMed]; Perp deletion promoted Th17 responses and exacerbated the development and severity of experimental autoimmune encephalomyelitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI77", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0007219 Notch signaling pathway;GO:0001894 tissue homeostasis;GO:0098609 cell-cell adhesion;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JK95-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTU0-1", "uniprot_id": [ { "id": "PHF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTU0", "type": "external" } ], "mass": 120814.0, "length": 1096, "protein_name": "Lysine-specific demethylase PHF2", "gene_name": "Phf2", "organism": "Mouse", "refseq_name": "lysine-specific demethylase PHF2", "refseq_ac": [ { "id": "NP_035208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035208", "type": "external" } ], "gene_names_uniprotkb": "Phf2; Kiaa0662", "gene_names_refseq": "GRC5; Phf2", "protein_names_uniprotkb": "Lysine-specific demethylase PHF2; 1.14.11.-; GRC5; PHD finger protein 2", "protein_names_refseq": "lysine-specific demethylase PHF2", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309)", "pathway": " (mmu:18676); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10051327;20129925;20173027;21183079;22921934;23806337;25428506;26495903;30084848;30779550;31219806;34428180;38241965;38701072;38808662", "class_list": "", "function": "Histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation, [RefSeq, PubMed]; Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:22921934). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (PubMed:22921934)., [UniProtKB, UniProtKB, PubMed]; PHF2 regulates genome topology and DNA replication in neural stem cells via cohesin., [RefSeq, PubMed]; PHF2 regulates sarcomeric gene transcription in myogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4[+] T cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6A023;Q80WA8", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0003713 transcription coactivator activity;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore;GO:1902494 catalytic complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006482 protein demethylation;GO:0061188 negative regulation of rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9WTU0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWM0-1", "uniprot_id": [ { "id": "PGES2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWM0", "type": "external" } ], "mass": 43324.0, "length": 384, "protein_name": "Prostaglandin E synthase 2", "gene_name": "Ptges2", "organism": "Mouse", "refseq_name": "prostaglandin E synthase 2", "refseq_ac": [ { "id": "NP_598544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598544", "type": "external" } ], "gene_names_uniprotkb": "Ptges2; Gbf1; Pges2", "gene_names_refseq": "0610038H10Rik; Gbf1; Mpges2; Pges2; Ptges2", "protein_names_uniprotkb": "Prostaglandin E synthase 2; 5.3.99.3; GATE-binding factor 1; GBF-1; Microsomal prostaglandin E synthase 2; mPGES-2", "protein_names_refseq": "GATE-binding factor 1; mPGES-2; microsomal prostaglandin E synthase 2; prostaglandin E synthase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:96979); (R-MMU-2162123); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12050152;12835322;15584915;15879117;19010439;21750661;22645316;25076362;31219806;35839302;37907523;38583151", "class_list": "", "function": "Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbalpha/FABP5 signaling., [RefSeq, PubMed]; Inhibition of mPGES-2 ameliorates NASH by activating NR1D1 via heme., [RefSeq, PubMed]; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear (PubMed:12050152)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]., [RefSeq]; Transactivators GBF1 and CCAAT/enhancer-binding protein-beta physically interact to induce interferon-gamma-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta in an IFN-inducible manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASQ2;Q99J30", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0043295 glutathione binding;GO:0003677 DNA binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0050220 prostaglandin-E synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0019371 cyclooxygenase pathway;GO:0046903 secretion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BWM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXS4-1", "uniprot_id": [ { "id": "PLXB2_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXS4", "type": "external" } ], "mass": 206230.0, "length": 1842, "protein_name": "Plexin-B2", "gene_name": "Plxnb2", "organism": "Mouse", "refseq_name": "plexin-B2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001152993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152993", "type": "external" } ], "gene_names_uniprotkb": "Plxnb2", "gene_names_refseq": "Debt; Plxnb2; plexin-B2", "protein_names_uniprotkb": "Plexin-B2", "protein_names_refseq": "differentially expressed in brain tumors; plexin-B2 isoform 1 precursor", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:140570)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;17554007;18250455;19144319;19349973;19948886;21122816;21183079;21966369;26495903;26740625;27802388;29100074;29981480;30779550;30899004;31219806;31599954;34114565;34418053;34428180;34887587;37828378;38781210;39048831", "class_list": "", "function": "Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia., [RefSeq, PubMed]; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (PubMed:17554007, PubMed:21122816). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (PubMed:29981480). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (PubMed:17554007). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (PubMed:19948886). Regulates the migration of cerebellar granule cells in the developing brain (PubMed:21122816). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity). Plays a role in axon guidance, invasive growth and cell migration (By similarity). May modulate the activity of RAC1 and CDC42 (PubMed:21966369). Down-regulates macrophage migration in wound-healing assays (in vitro) (PubMed:21966369)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; In vivo interaction screening reveals liver-derived constraints to metastasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 26, "disease_count": 2, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH76", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0017154 semaphorin receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0032055 negative regulation of translation in response to stress;GO:0007162 negative regulation of cell adhesion;GO:0010976 positive regulation of neuron projection development;GO:0043087 regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "B2RXS4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05622-1", "uniprot_id": [ { "id": "PGFRB_MOUSE", "url": "https://www.uniprot.org/uniprot/P05622", "type": "external" } ], "mass": 122790.0, "length": 1098, "protein_name": "Platelet-derived growth factor receptor beta", "gene_name": "Pdgfrb", "organism": "Mouse", "refseq_name": "platelet-derived growth factor receptor beta isoform 1 precursor", "refseq_ac": [ { "id": "NP_001139740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139740", "type": "external" } ], "gene_names_uniprotkb": "Pdgfrb; Pdgfr1; Pdgfr", "gene_names_refseq": "CD140b; PDGFR-1; Pdgfrb; Pdgfr", "protein_names_uniprotkb": "Platelet-derived growth factor receptor beta; 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1", "protein_names_refseq": "CD140 antigen-like family member B; PDGF beta chain; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta isoform 1 precursor; platelet-derived growth factor receptor beta", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); basal ganglia calcification (Disease Ontology:DOID:0060230); infantile myofibromatosis 1 (Disease Ontology:DOID:0070666); infantile myofibromatosis (Disease Ontology:DOID:0080109); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); extrahepatic cholestasis (Disease Ontology:DOID:13619); breast cancer (Disease Ontology:DOID:1612); myeloproliferative neoplasm (Disease Ontology:DOID:2226); Leydig cell tumor (Disease Ontology:DOID:2696); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); choriocarcinoma (Disease Ontology:DOID:3594); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); severe nonproliferative diabetic retinopathy (Disease Ontology:DOID:8946)", "pathway": " (mmu:18596); (R-MMU-1257604); (R-MMU-186763); (R-MMU-186797); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 6, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10454568;10644978;14514732;14624252;14966296;14993293;15207813;15284236;15753096;17620338;18213589;18515860;18948621;19030102;19656770;19742316;21664579;21750661;22645316;3020426;31219806;34428180;7521735;7730365;7958864;8041791;8440729", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM (By similarity). Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 21, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9QPE2", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0072223 metanephric glomerular mesangium development;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P05622-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08852-1", "uniprot_id": [ { "id": "PKD1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08852", "type": "external" } ], "mass": 466577.0, "length": 4293, "protein_name": "Polycystin-1", "gene_name": "Pkd1", "organism": "Mouse", "refseq_name": "polycystin-1 precursor", "refseq_ac": [ { "id": "NP_038658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038658", "type": "external" } ], "gene_names_uniprotkb": "Pkd1", "gene_names_refseq": "PC1; Pkd1; mFLJ00285", "protein_names_uniprotkb": "Polycystin-1; Autosomal dominant polycystic kidney disease 1 protein homolog", "protein_names_refseq": "autosomal dominant polycystic kidney disease 1 protein homolog; polycystic kidney disease 1 homolog; polycystin 1, transient receptor poteintial channel interacting; polycystin-1 precursor; polycystin-1", "tax_id": 10090, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intracranial aneurysm (Disease Ontology:DOID:10941); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:18763); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12514735;15548533;18003909;20096584;20856870;21750661;24939912;25405894;27214281;31219806;34428180;36210013;9107672", "class_list": "glycogene", "function": "Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity). Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 54, "predicted_n_glycosites": 51, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 284, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 4, "disease_count": 7, "glyco_site_count": 66, "binding_glycan_count": 0, "secondary_ac_list": "E9QJR6", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0044325 transmembrane transporter binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0002133 polycystin complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0048806 genitalia development;GO:0036303 lymph vessel morphogenesis;GO:0072218 metanephric ascending thin limb development;GO:0072237 metanephric proximal tubule development;GO:0072287 metanephric distal tubule morphogenesis", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "O08852-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83870-1", "uniprot_id": [ { "id": "PHF5A_MOUSE", "url": "https://www.uniprot.org/uniprot/P83870", "type": "external" } ], "mass": 12405.0, "length": 110, "protein_name": "PHD finger-like domain-containing protein 5A", "gene_name": "Phf5a", "organism": "Mouse", "refseq_name": "PHD finger-like domain-containing protein 5A", "refseq_ac": [ { "id": "NP_081013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081013", "type": "external" } ], "gene_names_uniprotkb": "Phf5a", "gene_names_refseq": "1110007B08Rik; Phf5a", "protein_names_uniprotkb": "PHD finger-like domain-containing protein 5A; PHD finger-like domain protein 5A; SF3b14b; Splicing factor 3B-associated 14 kDa protein", "protein_names_refseq": "PHD finger-like domain protein 5A; PHD finger-like domain-containing protein 5A; SF3b14b; splicing factor 3B-associated 14 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68479); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12054543;18758164;23806337;27749823;31219806", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (By similarity). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (By similarity). Within the 17S U2 SnRNP complex, PHF5A is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (By similarity). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Also involved in elongation by RNA polymerase II as part of the PAF1 complex (PAF1C) (PubMed:27749823). PAF1C is required for maintenance of embryonic stem cell (ESC) self-renewal and cellular reprogramming of stem cells (PubMed:27749823). Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes (PubMed:27749823). Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes (PubMed:27749823). Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies (PubMed:27749823). Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (PubMed:27749823). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Molecular cloning and characterization of Phf5a, [RefSeq, PubMed]; Phf5a controls differentiation of adult myoblasts, [RefSeq, PubMed]; Results indicate that PHF5A resembles a protein which interacts with splicing factors U2AF1 and SFRS5 and helicases EP400 and DDX1 and functions as a bridge protein between these proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQX7;Q9UH06", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048863 stem cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P83870-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64028-1", "uniprot_id": [ { "id": "PHC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64028", "type": "external" } ], "mass": 106060.0, "length": 1010, "protein_name": "Polyhomeotic-like protein 1", "gene_name": "Phc1", "organism": "Mouse", "refseq_name": "polyhomeotic-like protein 1 isoform a", "refseq_ac": [ { "id": "NP_001258508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258508", "type": "external" } ], "gene_names_uniprotkb": "Phc1; Edr1; Edr; Rae28", "gene_names_refseq": "Edr1; Edr; Mph1; Phc1; Rae-28; rae28", "protein_names_uniprotkb": "Polyhomeotic-like protein 1; Early development regulatory protein 1; RAE-28; mPH1", "protein_names_refseq": "early development regulator1 (homolog of polyhomeotic 1); early development regulatory protein 1; polyhomeotic-like 1; polyhomeotic-like protein 1 isoform a; polyhomeotic-like protein 1", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 11 (Disease Ontology:DOID:0070287); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:13619); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724); (R-MMU-8953750)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "10653359;16024804;21750661;22226355;34678516;36852467;8070621;9009205;9367423", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "P70359;Q64307;Q7TT35;Q8BZ80", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0097225 sperm midpiece;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0071300 cellular response to retinoic acid;GO:0045892 negative regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q64028-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3B1-1", "uniprot_id": [ { "id": "PLCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3B1", "type": "external" } ], "mass": 85873.0, "length": 756, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "gene_name": "Plcd1", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1", "refseq_ac": [ { "id": "NP_001280577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280577", "type": "external" } ], "gene_names_uniprotkb": "Plcd1; Plcd", "gene_names_refseq": "Plcd1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 3.1.4.11; PLC-delta-1; Phosphoinositide phospholipase C-delta-1; Phospholipase C-delta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; PLC-delta 1; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 Lf", "tax_id": 10090, "disease": "nonsyndromic congenital nail disorder 3 (Disease Ontology:DOID:0080081); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:18799); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10425196;16314520;19681039;21183079;33707294;34428180;34678590", "class_list": "", "function": "Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic beta-cells by activating Phospholipase C signal pathway in diabetic mice., [RefSeq, PubMed]; PLCdelta1 Plays Central Roles in the Osmotic Activation of DeltaN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine Osmoregulation., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Binds phosphatidylinositol 4,5-bisphosphate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1B4", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0010701 positive regulation of norepinephrine secretion;GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R3B1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4J7-1", "uniprot_id": [ { "id": "PHF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4J7", "type": "external" } ], "mass": 41139.0, "length": 364, "protein_name": "PHD finger protein 6", "gene_name": "Phf6", "organism": "Mouse", "refseq_name": "PHD finger protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001277475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277475", "type": "external" } ], "gene_names_uniprotkb": "Phf6; Kiaa1823", "gene_names_refseq": "2700007B13Rik; 4931428F02Rik; Phf6; mKIAA1823", "protein_names_uniprotkb": "PHD finger protein 6", "protein_names_refseq": "PHD finger protein 6 isoform 2", "tax_id": 10090, "disease": "Borjeson-Forssman-Lehmann syndrome (Disease Ontology:DOID:0050681); colorectal carcinoma (Disease Ontology:DOID:0080199); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:70998); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12415272;17698420;21183079;21750661;23791194;25605945;38429579;39004675;39181868", "class_list": "", "function": "As part of a cell-intrinsic transcriptional pathway, PHF6 regulates neuronal migration in the brain., [RefSeq, PubMed]; PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression. Publication Status: Online-Only, [RefSeq, PubMed]; PHF6 suppresses self-renewal of leukemic stem cells in AML., [RefSeq, PubMed]; PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS., [RefSeq, PubMed]; Strongest Phf6 gene expression and nuclear localisation of Phf6 protein were observed in the developing central nervous system, the anterior pituitary gland, the primordia of facial structures and the limb buds., [RefSeq, PubMed]; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80T86;Q8BYT8;Q8C1B5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0043021 ribonucleoprotein complex binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D4J7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70275-1", "uniprot_id": [ { "id": "SEM3E_MOUSE", "url": "https://www.uniprot.org/uniprot/P70275", "type": "external" } ], "mass": 89543.0, "length": 775, "protein_name": "Semaphorin-3E", "gene_name": "Sema3e", "organism": "Mouse", "refseq_name": "semaphorin-3E precursor", "refseq_ac": [ { "id": "NP_035478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035478", "type": "external" } ], "gene_names_uniprotkb": "Sema3e; Semah; Semh", "gene_names_refseq": "6430702L12; Sema3e; Semah; mKIAA0331", "protein_names_uniprotkb": "Semaphorin-3E; Sema H; Semaphorin-H", "protein_names_refseq": "sema H; semaphorin-3E precursor; semaphorin-3E; semaphorin-H", "tax_id": 10090, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:20349); (R-MMU-416700)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10430503;15550623;19421194;20385769;22179111;25428506;30846754;30899004;35820727;9515811", "class_list": "", "function": "Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O09078;O09079;Q9QX23", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0050808 synapse organization;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071526 semaphorin-plexin signaling pathway;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P70275-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Q6-1", "uniprot_id": [ { "id": "SEPT5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2Q6", "type": "external" } ], "mass": 42748.0, "length": 369, "protein_name": "Septin-5", "gene_name": "Septin5", "organism": "Mouse", "refseq_name": "septin-5", "refseq_ac": [ { "id": "NP_998779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998779", "type": "external" } ], "gene_names_uniprotkb": "Septin5; Pnutl1; Sept5", "gene_names_refseq": "Cdcrel-1; Cdcrel1; Pnutl1; Sept5; Septin5", "protein_names_uniprotkb": "Septin-5; CDCrel-1; Cell division control-related protein 1; Peanut-like protein 1", "protein_names_refseq": "cell division control-related protein 1; peanut-like 1 homolog; peanut-like protein 1; septin-5", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:18951)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11078524;11739749;11880646;15345747;17114649;17242355;17296554;18938227;21183079;21750661;24129315;25605945;33300544;34954322;36053822;36439885;38308620", "class_list": "", "function": "Downregulation of SEPTIN5 inhibits prostate cancer progression by increasing CD8[+] T cell infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion., [UniProtKB, PubMed]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysin., [RefSeq, PubMed]; Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUC5;Q3UYG4;Q6PB74", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005940 septin ring;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043195 terminal bouton", "go_biological_process": "GO:0030534 adult behavior;GO:0035176 social behavior;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z2Q6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9N1-1", "uniprot_id": [ { "id": "HYCCI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9N1", "type": "external" } ], "mass": 57321.0, "length": 521, "protein_name": "Hyccin", "gene_name": "Hycc1", "organism": "Mouse", "refseq_name": "hyccin isoform 2", "refseq_ac": [ { "id": "NP_001297400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297400", "type": "external" } ], "gene_names_uniprotkb": "Hycc1; Drctnnb1a; Fam126a", "gene_names_refseq": "Drctnnb1a; Fam126a; Hycc1", "protein_names_uniprotkb": "Hyccin; Down-regulated by CTNNB1 protein A", "protein_names_refseq": "down-regulated by CTNNB1 protein A; family with sequence similarity 126, member A; hyccin isoform 2; hyccin", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 5 (Disease Ontology:DOID:0060793)", "pathway": " (mmu:84652)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10910037;19144319;21183079;21750661;22461884;26571211;28935714;30016717;30084848;31219806;34428180;35820727;36210013", "class_list": "", "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway., [UniProtKB, UniProtKB]; Data show that in the brain, Hyccin transcript levels were higher in early postnatal development (postnatal days 2 and 10) and then declined in adult mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D3Z481;Q3TTP7;Q99NC4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0042552 myelination;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6P9N1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70205-1", "uniprot_id": [ { "id": "PACR_MOUSE", "url": "https://www.uniprot.org/uniprot/P70205", "type": "external" } ], "mass": 56640.0, "length": 496, "protein_name": "Pituitary adenylate cyclase-activating polypeptide type I receptor", "gene_name": "Adcyap1r1", "organism": "Mouse", "refseq_name": "pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_031433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031433", "type": "external" } ], "gene_names_uniprotkb": "Adcyap1r1", "gene_names_refseq": "2900024I10Rik; Adcyap1r1; PAC1R; PAC1; PACAP1-R", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP type I receptor; PACAP-R-1; PACAP-R1", "protein_names_refseq": "PACAP type I receptor; pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor; pituitary adenylate cyclase-activating polypeptide type I receptor", "tax_id": 10090, "disease": "cystitis (Disease Ontology:DOID:1679); post-traumatic stress disorder (Disease Ontology:DOID:2055)", "pathway": " (mmu:11517); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21183079;21750661;25428506;8664310", "class_list": "", "function": "G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0008179 adenylate cyclase binding;GO:0017046 peptide hormone binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0046058 cAMP metabolic process;GO:0006171 cAMP biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70205-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZ18-1", "uniprot_id": [ { "id": "ICE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZ18", "type": "external" } ], "mass": 109879.0, "length": 988, "protein_name": "Little elongation complex subunit 2", "gene_name": "Ice2", "organism": "Mouse", "refseq_name": "little elongation complex subunit 2", "refseq_ac": [ { "id": "NP_663593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663593", "type": "external" } ], "gene_names_uniprotkb": "Ice2; Narg2", "gene_names_refseq": "B230343B06Rik; Ice2; Narg2", "protein_names_uniprotkb": "Little elongation complex subunit 2; Interactor of little elongator complex ELL subunit 2; NMDA receptor-regulated protein 2", "protein_names_refseq": "NMDA receptor-regulated gene 2; NMDA receptor-regulated protein 2; interactor of little elongator complex ELL subunit 2; little elongation complex subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:93697); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11297529;15606750;17242355;21183079;21750661;30084848;31219806", "class_list": "", "function": "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0V2P1;Q66JS8;Q7TNL8;Q8BQZ1;Q8VEI2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex;GO:0016604 nuclear body", "go_biological_process": "GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UZ18-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NH2-1", "uniprot_id": [ { "id": "PARD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NH2", "type": "external" } ], "mass": 149075.0, "length": 1333, "protein_name": "Partitioning defective 3 homolog", "gene_name": "Pard3", "organism": "Mouse", "refseq_name": "partitioning defective 3 homolog isoform 2", "refseq_ac": [ { "id": "NP_001013598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013598", "type": "external" } ], "gene_names_uniprotkb": "Pard3; Par3", "gene_names_refseq": "Asip; D8Ertd580e; Par-3; Par3; Pard-3; Pard3a; Pard3; Phip", "protein_names_uniprotkb": "Partitioning defective 3 homolog; ASIP; Atypical PKC isotype-specific-interacting protein; Ephrin-interacting protein; PAR-3; PARD-3; PHIP", "protein_names_refseq": "atypical PKC isotype-specific-interacting protein; ephrin-interacting protein; par-3 (partitioning defective 3) homolog; partitioning defective 3 homolog isoform 2; partitioning defective 3 homolog", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:93742); (R-MMU-2173791); (R-MMU-420029)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10934474;10934475;11447115;11839275;15766746;17242355;19893486;20047332;20080746;21183079;21750661;21949390;23001562;34887587;9920925", "class_list": "", "function": "Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (PubMed:11839275). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58T10;Q58T11;Q8CB21", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0042802 identical protein binding;GO:0019903 protein phosphatase binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0006612 protein targeting to membrane;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99NH2-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70161-1", "uniprot_id": [ { "id": "PI51C_MOUSE", "url": "https://www.uniprot.org/uniprot/O70161", "type": "external" } ], "mass": 72408.0, "length": 661, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma", "gene_name": "Pip5k1c", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2", "refseq_ac": [ { "id": "NP_001140159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001140159", "type": "external" } ], "gene_names_uniprotkb": "Pip5k1c; Kiaa0589", "gene_names_refseq": "Pip5k1c; Pip5kIgamma", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; 2.7.1.68; PIP5K1-gamma; PIP5KIgamma; Phosphatidylinositol 4-phosphate 5-kinase type I gamma; PtdIns(4)P-5-kinase 1 gamma", "protein_names_refseq": "PIP5K1-gamma; phosphatidylinositol 4-phosphate 5-kinase type I gamma; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2; ptdIns(4)P-5-kinase 1 gamma", "tax_id": 10090, "disease": "lethal congenital contracture syndrome 3 (Disease Ontology:DOID:0060653); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18717); (R-MMU-1660499); (R-MMU-399955); (R-MMU-6811558); (R-MMU-8856828); (R-MMU-9768727)", "pathway_count": 6, "publication_count": 27, "publication_id_list": "11937028;12422219;12422220;14691141;14741049;15386003;15623515;16707488;17609388;17635937;17928408;19144319;19153220;19287005;20622009;20855869;21183079;21750661;22645316;22942276;24129315;31219806;33300544;34996482;35090892;40885482;9535851", "class_list": "", "function": "Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:14741049, PubMed:20622009, PubMed:22942276, PubMed:9535851). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (PubMed:19153220). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (PubMed:15386003). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (By similarity). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:16707488). Required for clathrin-coated pits assembly at the synapse (By similarity). Participates in cell junction assembly (By similarity). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (By similarity). Required for focal adhesion dynamics (PubMed:12422220). Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (By similarity). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (By similarity). Required for uropodium formation and retraction of the cell rear during directed migration (PubMed:17928408). Has a role in growth factor-stimulated directional cell migration and adhesion (PubMed:17635937). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (PubMed:20855869). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (PubMed:20855869). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (PubMed:17609388, PubMed:20622009)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling., [RefSeq, PubMed]; Type I PIPkinases interact with and are regulated by the retinoblastoma susceptibility gene product-pRB., [RefSeq, PubMed]; We show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction, [RefSeq, PubMed]; We show that the type I phosphatidylinositol phosphate kinase isoform-gamma 661 (PIPKI gamma 661), an enzyme that makes PtdIns(4,5)P(2), is targeted to focal adhesions by an association with talin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q505A1;Q80TW9;Q8VCU5", "ec_number_list": [ { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:1990147 talin binding;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098835 presynaptic endocytic zone membrane;GO:0001891 phagocytic cup;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006935 chemotaxis;GO:0007409 axonogenesis;GO:0006909 phagocytosis;GO:0070527 platelet aggregation;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "O70161-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZA3-1", "uniprot_id": [ { "id": "PCCA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZA3", "type": "external" } ], "mass": 79922.0, "length": 724, "protein_name": "Propionyl-CoA carboxylase alpha chain, mitochondrial", "gene_name": "Pcca", "organism": "Mouse", "refseq_name": "propionyl-CoA carboxylase alpha chain, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_659093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659093", "type": "external" } ], "gene_names_uniprotkb": "Pcca", "gene_names_refseq": "Pcca", "protein_names_uniprotkb": "Propionyl-CoA carboxylase alpha chain, mitochondrial; 6.4.1.3; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha", "protein_names_refseq": "PCCase subunit alpha; propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA-carboxylase alpha; propionyl-CoA carboxylase alpha chain, mitochondrial isoform 1 precursor; propionyl-CoA carboxylase alpha chain, mitochondrial", "tax_id": 10090, "disease": "propionic acidemia (Disease Ontology:DOID:14701); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:110821); (R-MMU-196780); (R-MMU-71032)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11461925;17242355;21183079;21750661;23438705;23576753;23806337;28011936;31219806;34428180;36288343;37453647;37507081;37828378;38811689;39927985", "class_list": "", "function": "Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to Pcca mutation. Publication Status: Online-Only, [RefSeq, PubMed]; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VU5;Q922N3", "ec_number_list": [ { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0004658 propionyl-CoA carboxylase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1902494 catalytic complex", "go_biological_process": "GO:0016042 lipid catabolic process;GO:1901290 succinyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91ZA3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CII8-1", "uniprot_id": [ { "id": "SYNE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CII8", "type": "external" } ], "mass": 42024.0, "length": 388, "protein_name": "Nesprin-4", "gene_name": "Syne4", "organism": "Mouse", "refseq_name": "nesprin-4 isoform 1", "refseq_ac": [ { "id": "NP_705805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705805", "type": "external" } ], "gene_names_uniprotkb": "Syne4; AI428936", "gene_names_refseq": "0610012K07Rik; KASH4; Nesp4; Syne4", "protein_names_uniprotkb": "Nesprin-4; KASH domain-containing protein 4; KASH4; Nuclear envelope spectrin repeat protein 4", "protein_names_refseq": "KASH domain-containing protein 4; nesprin-4 isoform 1; nesprin-4; nuclear envelope spectrin repeat protein 4", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 76 (Disease Ontology:DOID:0110524)", "pathway": " (mmu:233066)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19164528;21750661;23348741", "class_list": "", "function": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology, by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus., [UniProtKB, PubMed]; Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PH99;Q99J42", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005640 nuclear outer membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CII8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPF3-1", "uniprot_id": [ { "id": "TIAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPF3", "type": "external" } ], "mass": 192567.0, "length": 1715, "protein_name": "Rho guanine nucleotide exchange factor TIAM2", "gene_name": "Tiam2", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor TIAM2 isoform 1", "refseq_ac": [ { "id": "NP_001116470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116470", "type": "external" } ], "gene_names_uniprotkb": "Tiam2; Kiaa2016; Stef", "gene_names_refseq": "3000002F19Rik; STEF; Tiam2; mKIAA2016", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2", "protein_names_refseq": "RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; SIF and TIAM1-like exchange factor; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; rho guanine nucleotide exchange factor TIAM2 isoform 1; rho guanine nucleotide exchange factor TIAM2", "tax_id": 10090, "disease": "cataract 48 (Disease Ontology:DOID:0070354); neurodevelopmental disorder with language delay and seizures (Disease Ontology:DOID:0070444)", "pathway": " (mmu:24001); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10364228;10512681;11707441;11900975;12912917;14550769;17320046;19893486;21183079;21750661;31908036;34418053;35820727;37801065;38871458", "class_list": "", "function": "Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; RhoGEF Tiam2 Regulates Glutamatergic Synaptic Transmission in Hippocampal CA1 Pyramidal Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior., [RefSeq, PubMed]; TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSM6;Q3TZ33;Q6AXF2;Q6NXJ2;Q9JLY2;Q9WVS3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0050772 positive regulation of axonogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q6ZPF3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KMM3-1", "uniprot_id": [ { "id": "OXR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KMM3", "type": "external" } ], "mass": 95912.0, "length": 866, "protein_name": "Oxidation resistance protein 1", "gene_name": "Oxr1", "organism": "Mouse", "refseq_name": "oxidation resistance protein 1 isoform B", "refseq_ac": [ { "id": "NP_001123635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123635", "type": "external" } ], "gene_names_uniprotkb": "Oxr1; C7; Gm1238", "gene_names_refseq": "2210416C20Rik; C7B; C7; Oxr1", "protein_names_uniprotkb": "Oxidation resistance protein 1; Protein C7", "protein_names_refseq": "nucleolar protein C7; oxidation resistance protein 1 isoform B; oxidation resistance protein 1; protein C7", "tax_id": 10090, "disease": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (Disease Ontology:DOID:0070339)", "pathway": " (mmu:170719)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11237729;17114649;21183079;21750661;22028674;22645316;26668325;31219806;32848054;34505865;34811399;35822049;40021952;40445757;40885482", "class_list": "", "function": "Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (PubMed:40445757). Involved in protection from oxidative damage (PubMed:22028674, PubMed:26668325). Protects neuronal cells from oxidative stress (PubMed:22028674, PubMed:26668325)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; May be involved in protection from oxidative damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWW1;Q99L06;Q99MK1;Q99MP4", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0051402 neuron apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0007628 adult walking behavior;GO:0071447 cellular response to hydroperoxide", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q4KMM3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMK2-1", "uniprot_id": [ { "id": "KC1E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMK2", "type": "external" } ], "mass": 47322.0, "length": 416, "protein_name": "Casein kinase I isoform epsilon", "gene_name": "Csnk1e", "organism": "Mouse", "refseq_name": "casein kinase I isoform epsilon isoform a", "refseq_ac": [ { "id": "NP_001276827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276827", "type": "external" } ], "gene_names_uniprotkb": "Csnk1e", "gene_names_refseq": "CK1epsilon; CKIe; Csnk1e; KC1epsilon; tau", "protein_names_uniprotkb": "Casein kinase I isoform epsilon; 2.7.11.1; CKI-epsilon; CKIe", "protein_names_refseq": "CKI-epsilon; KC1 epsilon; casein kinase I isoform epsilon isoform a", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); Alzheimer's disease (Disease Ontology:DOID:10652); colon cancer (Disease Ontology:DOID:219); invasive ductal carcinoma (Disease Ontology:DOID:3008)", "pathway": " (mmu:27373); (R-MMU-201688); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6791226); (R-MMU-69601); (R-MMU-8854518)", "pathway_count": 11, "publication_count": 19, "publication_id_list": "10640823;10848614;11779462;12183362;14701732;16452087;16790549;17525164;18400165;19414593;21750661;21930935;24129315;29191835;34203471;34428180;34514665;36210013;37578019", "class_list": "", "function": "Casein kinase 1 epsilon and circadian misalignment impact affective behaviours in mice., [RefSeq, PubMed]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates DVL1 (By similarity). Phosphorylates DVL2 (By similarity). Phosphorylates NEDD9/HEF1 (PubMed:29191835). Central component of the circadian clock (PubMed:18400165, PubMed:19414593, PubMed:21930935). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:18400165, PubMed:19414593, PubMed:21930935). Controls PER1 and PER2 nuclear transport and degradation (PubMed:10848614, PubMed:14701732, PubMed:18400165, PubMed:19414593, PubMed:21930935). Inhibits cytokine-induced granuloytic differentiation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2., [RefSeq, PubMed]; The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R389", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:1902004 positive regulation of amyloid-beta formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JMK2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03526-1", "uniprot_id": [ { "id": "ITK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03526", "type": "external" } ], "mass": 72292.0, "length": 625, "protein_name": "Tyrosine-protein kinase ITK/TSK", "gene_name": "Itk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase ITK/TSK isoform 1", "refseq_ac": [ { "id": "NP_001268894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268894", "type": "external" } ], "gene_names_uniprotkb": "Itk; Emt; Tlk; Tsk", "gene_names_refseq": "Emt; Itk; Tcsk; Tsk", "protein_names_uniprotkb": "Tyrosine-protein kinase ITK/TSK; 2.7.10.2; IL-2-inducible T-cell kinase; Kinase EMT; Kinase TLK; T-cell-specific kinase", "protein_names_refseq": "T-cell-specific kinase; interleukin-2-inducible T cell kinase; kinase TLK; tyrosine-protein kinase ITK/TSK isoform 1; tyrosine-protein kinase ITK/TSK", "tax_id": 10090, "disease": "lymphoproliferative syndrome 1 (Disease Ontology:DOID:0060707)", "pathway": " (mmu:16428); (R-MMU-202433); (R-MMU-2871809)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10213685;10570288;1280821;15662016;16860760;19597499;20237289;21036902;21750661;23562159;31219806;37175808;39042726;7524075;8421704;8476425;8777721;8943565;8985255", "class_list": "", "function": "Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The kinase ITK controls a Ca[2+]-mediated switch that balances TH17 and Treg cell differentiation., [RefSeq, PubMed]; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (PubMed:23562159). Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3 (PubMed:15662016)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0050852 T cell receptor signaling pathway;GO:0001819 positive regulation of cytokine production;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q03526-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIY0-1", "uniprot_id": [ { "id": "PKHO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIY0", "type": "external" } ], "mass": 45997.0, "length": 408, "protein_name": "Pleckstrin homology domain-containing family O member 1", "gene_name": "Plekho1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family O member 1 isoform 1", "refseq_ac": [ { "id": "NP_075809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075809", "type": "external" } ], "gene_names_uniprotkb": "Plekho1", "gene_names_refseq": "2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2; Plekho1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 1; PH domain-containing family O member 1", "protein_names_refseq": "CK2 interacting protein 1; Jun zipper-associated 2; PH domain-containing family O member 1; TNF intracellular domain-interacting protein; pleckstrin homology domain-containing family O member 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67220)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16987810;17942896;18641638;19144319;21750661;23151343;34875910;36347273;36631036;37351817;38871861", "class_list": "", "function": "CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy., [RefSeq, PubMed]; CKIP-1 functions as the first auxiliary factor to enhance the activation of Smurf1. Erratum:[Nat Cell Biol. 2010 Jun;12(6):625], [RefSeq, PubMed]; CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein, [RefSeq, PubMed]; CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A., [RefSeq, PubMed]; Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization., [RefSeq, PubMed]; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity)., [UniProtKB, PubMed]; The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article)., [RefSeq, PubMed]; [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXH2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0032587 ruffle membrane;GO:0036195 muscle cell projection membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007520 myoblast fusion;GO:0008360 regulation of cell shape;GO:0072673 lamellipodium morphogenesis;GO:0051451 myoblast migration;GO:1901739 regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JIY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQG1-1", "uniprot_id": [ { "id": "PKHA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQG1", "type": "external" } ], "mass": 131427.0, "length": 1173, "protein_name": "Pleckstrin homology domain-containing family A member 6", "gene_name": "Plekha6", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family A member 6 isoform 1", "refseq_ac": [ { "id": "NP_891846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891846", "type": "external" } ], "gene_names_uniprotkb": "Plekha6; Pepp3", "gene_names_refseq": "9530028L01Rik; Pepp3; Plekha6", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 6; PEPP-3; PH domain-containing family A member 6; Phosphoinositol 3-phosphate-binding protein 3", "protein_names_refseq": "PEPP-3; PH domain-containing family A member 6; phosphoinositol 3-phosphate-binding protein-3; pleckstrin homology domain-containing family A member 6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:240753); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17242355;18034455;19144319;21183079;21750661;30084848;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0J5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7TQG1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DFV7-1", "uniprot_id": [ { "id": "NCOA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DFV7", "type": "external" } ], "mass": 106357.0, "length": 943, "protein_name": "Nuclear receptor coactivator 7", "gene_name": "Ncoa7", "organism": "Mouse", "refseq_name": "nuclear receptor coactivator 7 isoform 2", "refseq_ac": [ { "id": "NP_001104737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104737", "type": "external" } ], "gene_names_uniprotkb": "Ncoa7", "gene_names_refseq": "9030406N13Rik; Ncoa7", "protein_names_uniprotkb": "Nuclear receptor coactivator 7", "protein_names_refseq": "nuclear receptor coactivator 7 isoform 2", "tax_id": 10090, "disease": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (Disease Ontology:DOID:0070339)", "pathway": " (mmu:211329)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11971969;18299425;20446107;21183079;21750661;26668325;29384414;33340069;34811399;37511343;40445757", "class_list": "", "function": "ERAP 140 interacts with ER beta and its interaction decreases but its expression increases with age in mouse cerebral cortex., [RefSeq, PubMed]; Exhibits oxidation resistance activity (PubMed:26668325). Protects neuronal cells from oxidative stress with stronger neuroprotective activity than isoform 1 (PubMed:26668325). Inhibits endosome-mediated viral entry by inhibiting fusion of the viral and endosomal membranes and subsequent nuclear translocation of viral ribonucleoproteins (By similarity). Promotes increased cytoplasmic vesicular acidification, lysosomal protease activity and the degradation of endocytosed material (By similarity)., [UniProtKB, UniProtKB, PubMed]; NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour., [RefSeq, PubMed]; Transcriptional coactivator which enhances the transcriptional activities of several nuclear receptors including ESR1, THRB, PPARG and RARA (By similarity). Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (PubMed:40445757). Required to stabilize V-ATPase V1 subunits ATP6V1B2 and ATP6V1A at membrane sites (PubMed:33340069). Involved in protection against oxidative damage (PubMed:26668325). Involved in urine acidification (PubMed:29384414)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9Q6S9;Q3TAR1;Q3UNB3;Q66K05;Q6ZQM4;Q8BJ15;Q8BJ39", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6DFV7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1N2-1", "uniprot_id": [ { "id": "PHLB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1N2", "type": "external" } ], "mass": 141486.0, "length": 1249, "protein_name": "Pleckstrin homology-like domain family B member 2", "gene_name": "Phldb2", "organism": "Mouse", "refseq_name": "pleckstrin homology-like domain family B member 2 isoform 1", "refseq_ac": [ { "id": "NP_001239371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239371", "type": "external" } ], "gene_names_uniprotkb": "Phldb2; Ll5b", "gene_names_refseq": "C820004H04Rik; LL5beta; LL5b; Phldb2", "protein_names_uniprotkb": "Pleckstrin homology-like domain family B member 2; Protein LL5-beta", "protein_names_refseq": "pleckstrin homology-like domain family B member 2 isoform 1; protein LL5-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:208177)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "15851520;17242355;19131326;21183079;21750661;23525008;24885555;25428506;25589673;28528544;30084848;30779550;30867511;31599954;32782141;34428180;34887587;35820727;36162735;36210013", "class_list": "", "function": "A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane., [RefSeq, PubMed]; PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover. Publication Status: Online-Only, [RefSeq, PubMed]; Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner., [RefSeq, PubMed]; Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane., [UniProtKB, PubMed]; These results provide evidence for an important contribution of the BMP2-PI3K (p55gamma/p110alpha)- PIP3-LL5beta signalling axis in mesenchymal progenitor cell chemotaxis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNI3;Q80Y16;Q8BKV3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045180 basal cortex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0016477 cell migration;GO:0045184 establishment of protein localization;GO:0051895 negative regulation of focal adhesion assembly;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8K1N2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM47-1", "uniprot_id": [ { "id": "PKHM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM47", "type": "external" } ], "mass": 86553.0, "length": 761, "protein_name": "Pleckstrin homology domain-containing family M member 3", "gene_name": "Plekhm3", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family M member 3", "refseq_ac": [ { "id": "NP_001034582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034582", "type": "external" } ], "gene_names_uniprotkb": "Plekhm3; Dapr", "gene_names_refseq": "9430067K14Rik; A230102O09Rik; DAPR; Plekhm1l; Plekhm3", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 3; Differentiation-associated protein; PH domain-containing family M member 3", "protein_names_refseq": "PH domain-containing family M member 3; differentiation associated protein; pleckstrin homology domain-containing family M member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:241075)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19028694;19144319;21750661;31219806;33597502", "class_list": "", "function": "DAPR is a novel gene that binds to PKB/AKT and is a critical component for the differentiation of skeletal muscle myoblast cells into myotubes., [RefSeq, PubMed]; Involved in skeletal muscle differentiation (PubMed:19028694). May act as a scaffold protein for AKT1 during muscle differentiation (PubMed:19028694)., [UniProtKB, PubMed]; The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9Y1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0045445 myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BM47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3Q7-1", "uniprot_id": [ { "id": "PACS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3Q7", "type": "external" } ], "mass": 94932.0, "length": 862, "protein_name": "Phosphofurin acidic cluster sorting protein 2", "gene_name": "Pacs2", "organism": "Mouse", "refseq_name": "phosphofurin acidic cluster sorting protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001278374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278374", "type": "external" } ], "gene_names_uniprotkb": "Pacs2; Kiaa0602; Pacs1l", "gene_names_refseq": "6720425G15Rik; E230011J22; Pacs1l; Pacs2; mKIAA0602", "protein_names_uniprotkb": "Phosphofurin acidic cluster sorting protein 2; PACS-2; PACS1-like protein", "protein_names_refseq": "PACS1-like protein; phosphofurin acidic cluster sorting protein 2 isoform 3", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 66 (Disease Ontology:DOID:0080446)", "pathway": " (mmu:217893)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18296443;19481529;21183079;21750661;25159152;26943323;31219806;35822049;37794057;38169625;40021952;40885482", "class_list": "", "function": "CS-2 traffics to the nucleus where it regulates SIRT1-mediated p53 deacetylation. PACS-2 binds SIRT1 in vitro and directly inhibits SIRT1-catalyzed p53 deacetylation., [RefSeq, PubMed]; MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments (By similarity)., [UniProtKB, UniProtKB]; PACS-2 coordinates p53/p21- dependent cell cycle arrest with NF-kappaB/Bcl-xL-dependent pro-survival signaling to support DNA repair in response to genotoxic damage., [RefSeq, PubMed]; PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy. Publication Status: Online-Only, [RefSeq, PubMed]; PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system, [RefSeq, PubMed]; Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKL3;Q80TW2;Q80VG3", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0072659 protein localization to plasma membrane;GO:0006915 apoptotic process;GO:0034497 protein localization to phagophore assembly site;GO:0032469 endoplasmic reticulum calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3V3Q7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXZ1-1", "uniprot_id": [ { "id": "PNDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXZ1", "type": "external" } ], "mass": 61292.0, "length": 531, "protein_name": "Poly(A)-specific ribonuclease PNLDC1", "gene_name": "Pnldc1", "organism": "Mouse", "refseq_name": "poly(A)-specific ribonuclease PNLDC1", "refseq_ac": [ { "id": "NP_001030038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030038", "type": "external" } ], "gene_names_uniprotkb": "Pnldc1", "gene_names_refseq": "Gm313; Pnldc1", "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PNLDC1; 3.1.13.4; PARN-like domain-containing protein 1; Poly(A)-specific ribonuclease domain-containing protein 1", "protein_names_refseq": "PARN-like domain-containing protein 1; poly(A)-specific ribonuclease PARN-like domain-containing protein 1; poly(A)-specific ribonuclease PNLDC1; poly(A)-specific ribonuclease domain-containing protein 1", "tax_id": 10090, "disease": "spermatogenic failure 57 (Disease Ontology:DOID:0112338)", "pathway": " (mmu:240023)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;26919431;27515512;28994417;29018194;29444933", "class_list": "", "function": "3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (PubMed:27515512). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (By similarity)., [UniProtKB, PubMed, UniProtKB]; PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice. Publication Status: Online-Only, [RefSeq, PubMed]; PNLDC1-mediated piRNA trimming is indispensable for the function of piRNAs throughout mouse spermatogenesis., [RefSeq, PubMed]; PNLDC1/PARN-1 has a conserved role in 3' trimming during piRNA maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0034587 piRNA processing;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RXZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84228-1", "uniprot_id": [ { "id": "H32_MOUSE", "url": "https://www.uniprot.org/uniprot/P84228", "type": "external" } ], "mass": 15388.0, "length": 136, "protein_name": "Histone H3.2", "gene_name": "H3c13; H3c14; H3c15; H3c2; H3c3; H3c4; H3c6; H3c7", "organism": "Mouse", "refseq_name": "histone H3.2", "refseq_ac": [ { "id": "NP_038576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038576", "type": "external" } ], "gene_names_uniprotkb": "H3c13; H3c14; H3c15; H3c2; H3c3; H3c4; H3c6; H3c7; H3-143; H3-53; H3-B; H3-F; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3.2; H3b; H3f; Hist1h3b; Hist1h3c; Hist1h3d; Hist1h3e; Hist1h3f; Hist2h3b; Hist2h3c1; Hist2h3c2; Hist2h3ca1; Hist2h3ca2", "gene_names_refseq": "H3.2-221; H3c13; H3c14; H3c15; H3c2; H3c3; H3c4; H3c6; H3c7; Hist1h3f; Hist1", "protein_names_uniprotkb": "Histone H3.2; H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; H3-clustered histone 2; H3-clustered histone 3; H3-clustered histone 4; H3-clustered histone 6; H3-clustered histone 7", "protein_names_refseq": "H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; H3-clustered histone 2; H3-clustered histone 3; H3-clustered histone 4; H3-clustered histone 6; histone 1, H3f; histone H3.2; histone H3; histone cluster 1, H3f; histone gene complex 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15077); (mmu:260423); (mmu:319148); (mmu:319149); (mmu:319150); (mmu:319151); (mmu:319154); (mmu:97114); (R-MMU-1266695); (R-MMU-212300); (R-MMU-2299718); (R-MMU-3214841); (R-MMU-3214842); (R-MMU-3214847); (R-MMU-3214858); (R-MMU-3247509); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9764725); (R-MMU-983231); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 24, "publication_count": 45, "publication_id_list": "10464286;11441012;11751582;11856369;12408966;12498683;13678296;15339660;15485929;15616592;15681610;15684425;15735677;15870105;16075062;17189264;17194708;20122409;21750661;21925322;22389435;2249786;24681537;2587235;27105113;27105115;30154464;3027355;30279482;30867594;31645732;32152506;33300544;33725478;34168076;34887587;36288343;37082731;37507081;38567720;6314253;8001786;8065931;8858344;8858345", "class_list": "", "function": "Asymmetrical deposition and modification of histone H3 variants are essential for zygote development. Publication Status: Online-Only, [RefSeq, PubMed]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; H3.1/3.2 regulate the initial progression of the gene expression program., [RefSeq, PubMed]; Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMN6;P02295;P02297;P16105;P17269;P17320;Q60582;Q78E59;Q8CGN9", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0040029 epigenetic regulation of gene expression;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P84228-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQM4-1", "uniprot_id": [ { "id": "HEAT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQM4", "type": "external" } ], "mass": 74305.0, "length": 679, "protein_name": "HEAT repeat-containing protein 3", "gene_name": "Heatr3", "organism": "Mouse", "refseq_name": "HEAT repeat-containing protein 3", "refseq_ac": [ { "id": "NP_766345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766345", "type": "external" } ], "gene_names_uniprotkb": "Heatr3", "gene_names_refseq": "C030036P15Rik; Heatr3", "protein_names_uniprotkb": "HEAT repeat-containing protein 3; Symportin Syo1", "protein_names_refseq": "HEAT repeat-containing protein 3; symportin Syo1", "tax_id": 10090, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:234549)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21183079;21750661;24788674;25153642;25428506;30084848;31599954;33649389;34203471;34428180;35820727;37828378", "class_list": "", "function": "Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5). Required for proper erythrocyte maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C731", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0042273 ribosomal large subunit biogenesis;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BQM4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKS5-1", "uniprot_id": [ { "id": "HABP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKS5", "type": "external" } ], "mass": 45924.0, "length": 411, "protein_name": "Intracellular hyaluronan-binding protein 4", "gene_name": "Habp4", "organism": "Mouse", "refseq_name": "intracellular hyaluronan-binding protein 4", "refseq_ac": [ { "id": "NP_064370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064370", "type": "external" } ], "gene_names_uniprotkb": "Habp4", "gene_names_refseq": "4933413D03Rik; 4933428J01Rik; Habp4", "protein_names_uniprotkb": "Intracellular hyaluronan-binding protein 4; Hyaluronic acid-binding protein 4; IHABP-4; IHABP4", "protein_names_refseq": "IHABP-4; IHABP4; hyaluronic acid-binding protein 4 (intracellular); intracellular hyaluronan-binding protein 4; intracellular hyaluronan-binding protein p57", "tax_id": 10090, "disease": "", "pathway": " (mmu:56541); (R-MMU-114608)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10887182;16452087;19523114;21183079;21750661;23894536;40684658", "class_list": "glycogene", "function": "Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing. Binds (via C-terminus) to poly(U) RNA. Seems to play a role in PML-nuclear bodies formation (By similarity). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNH8;Q9D450", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0061770 translation elongation factor binding;GO:0005540 hyaluronic acid binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0030578 PML body organization;GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JKS5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62806-1", "uniprot_id": [ { "id": "H4_MOUSE", "url": "https://www.uniprot.org/uniprot/P62806", "type": "external" } ], "mass": 11367.0, "length": 103, "protein_name": "Histone H4", "gene_name": "H4c11; H4c12; H4c14; H4c16; H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; Hist1h4m", "organism": "Mouse", "refseq_name": "histone H4", "refseq_ac": [ { "id": "NP_001182350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182350", "type": "external" } ], "gene_names_uniprotkb": "H4c11; H4c12; H4c14; H4c16; H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; Hist1h4m; H4-12; H4-53; H4f16; Hist1h4a; Hist1h4b; Hist1h4c; Hist1h4d; Hist1h4f; Hist1h4h; Hist1h4i; Hist1h4j; Hist1h4k; Hist2h4a; Hist2h4; Hist4h4", "gene_names_refseq": "Gm11275; H4c11; H4c12; H4c14; H4c16; H4c17; H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4m", "protein_names_uniprotkb": "Histone H4", "protein_names_refseq": "histone H4; histone cluster 1, H4m", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041230); (mmu:319155); (mmu:319156); (mmu:319157); (mmu:319158); (mmu:319159); (mmu:319160); (mmu:319161); (mmu:320332); (mmu:326619); (mmu:326620); (mmu:69386); (mmu:97122); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214841); (R-MMU-3214842); (R-MMU-3214847); (R-MMU-3214858); (R-MMU-4551638); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 36, "publication_count": 52, "publication_id_list": "11101893;11180120;12408966;15145825;16699504;16980586;17292472;17947660;18034455;18187659;18250455;21183079;21925322;22389435;23576753;23806337;24049080;24681537;25605945;26740625;27105113;27105115;28011936;2915930;30154464;30279482;31219806;31645732;32152506;32726616;33300544;33649389;33725478;34185806;34203471;34428180;34887587;35820727;35984892;36084651;36210013;36288343;37453647;37507081;37731000;37828378;39627609;39927985;6276563;8676066;8858344;9449717", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AUM5;A4FUP8;A4QMY0;P02304;P02305;Q0VDL9;Q2M2Q5;Q5T006;Q6PDS7;Q811M0;Q9D0C9;Q9D6Q8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0061644 protein localization to CENP-A containing chromatin", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P62806-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68433-1", "uniprot_id": [ { "id": "H31_MOUSE", "url": "https://www.uniprot.org/uniprot/P68433", "type": "external" } ], "mass": 15404.0, "length": 136, "protein_name": "Histone H3.1", "gene_name": "H3c10; H3c11; H3c1; H3c8", "organism": "Mouse", "refseq_name": "histone H3.1", "refseq_ac": [ { "id": "NP_038578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038578", "type": "external" } ], "gene_names_uniprotkb": "H3c10; H3c11; H3c1; H3c8; H3.1-221; H3.1-291; H3.1-I; H3a; H3g; H3h; H3i; Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i", "gene_names_refseq": "H3c10; H3c11; H3c1; H3c8; Hist1h3a", "protein_names_uniprotkb": "Histone H3.1", "protein_names_refseq": "histone 1, H3a; histone H3.1; histone cluster 1, H3a", "tax_id": 10090, "disease": "", "pathway": " (mmu:319152); (mmu:319153); (mmu:360198); (mmu:97908); (R-MMU-1266695); (R-MMU-212300); (R-MMU-2299718); (R-MMU-3214841); (R-MMU-3214842); (R-MMU-3214847); (R-MMU-3214858); (R-MMU-3247509); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9764725); (R-MMU-983231); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 20, "publication_count": 44, "publication_id_list": "10464286;11441012;11747826;11751582;11856369;12234980;12408966;12498683;13678296;15339660;15485929;15616592;15681610;15684425;15735677;15870105;17189264;17194708;18243098;20122409;20173027;21925322;22389435;24681537;2587222;26495903;27045799;27105113;27105115;28315936;30154464;3018484;3027355;30279482;30867594;31645732;33300544;34428180;34887587;35984892;36288343;38733581;6314253;8858344", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone recognition. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]; Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Erratum:[Cell Rep. 2024 Oct 22;43(10):114884. doi: 10.1016/j.celrep.2024.114884. PMID: 39392757], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02295;P02296;P16106;Q05A97;Q3B7Z8;Q3B7Z9;Q5T009", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P68433-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHX2-1", "uniprot_id": [ { "id": "HAP28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHX2", "type": "external" } ], "mass": 20605.0, "length": 181, "protein_name": "28 kDa heat- and acid-stable phosphoprotein", "gene_name": "Pdap1", "organism": "Mouse", "refseq_name": "28 kDa heat- and acid-stable phosphoprotein", "refseq_ac": [ { "id": "NP_001028485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028485", "type": "external" } ], "gene_names_uniprotkb": "Pdap1", "gene_names_refseq": "HASPP28; PAP1; PAP; Pdap1", "protein_names_uniprotkb": "28 kDa heat- and acid-stable phosphoprotein; PAP1; PAP; PDGF-associated protein; PDGFA-associated protein 1", "protein_names_refseq": "28 kDa heat- and acid-stable phosphoprotein; PDGF-associated protein", "tax_id": 10090, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:231887); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16075062;17242355;17622165;18630941;19131326;21183079;23806337;26495903;32609329;37507081", "class_list": "", "function": "PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JLS1;Q3KQJ5", "ec_number_list": [], "go_molecular_function": "GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0048008 platelet-derived growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UHX2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZS7-1", "uniprot_id": [ { "id": "HBS1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZS7", "type": "external" } ], "mass": 75100.0, "length": 682, "protein_name": "HBS1-like protein", "gene_name": "Hbs1l", "organism": "Mouse", "refseq_name": "HBS1-like protein isoform 1", "refseq_ac": [ { "id": "NP_062676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062676", "type": "external" } ], "gene_names_uniprotkb": "Hbs1l; Gm9923; Hbs1; Kiaa1038", "gene_names_refseq": "2810035F15Rik; Hbs1l; eRFS", "protein_names_uniprotkb": "HBS1-like protein; 3.6.5.-", "protein_names_refseq": "HBS1-like protein isoform 1; HBS1-like protein; eukaryotic release factor 3", "tax_id": 10090, "disease": "beta thalassemia (Disease Ontology:DOID:12241)", "pathway": " (mmu:56422); (R-MMU-429958); (R-MMU-9954714)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23806337;33899734;34428180;35820727;9872408", "class_list": "", "function": "Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z32;Q9CVT2;Q9CZ95;Q9WTY5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:1990533 Dom34-Hbs1 complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006417 regulation of translation;GO:0006412 translation;GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q69ZS7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP66-1", "uniprot_id": [ { "id": "HCAR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP66", "type": "external" } ], "mass": 41401.0, "length": 360, "protein_name": "Hydroxycarboxylic acid receptor 2", "gene_name": "Hcar2", "organism": "Mouse", "refseq_name": "hydroxycarboxylic acid receptor 2", "refseq_ac": [ { "id": "NP_109626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109626", "type": "external" } ], "gene_names_uniprotkb": "Hcar2; Gpr109a; Gpr109b; Gpr109; Niacr1; Pumag", "gene_names_refseq": "Gpr109a; Gpr109b; HM74; Hcar2; Niacr1; PUMA-G; Pumag; mHM74b", "protein_names_uniprotkb": "Hydroxycarboxylic acid receptor 2; G protein-coupled receptor 109A; G protein-coupled receptor 109; G protein-coupled receptor HM74; Niacin receptor 1; Nicotinic acid receptor; Protein PUMA-G", "protein_names_refseq": "G protein-coupled receptor 109A; G protein-coupled receptor 109B; G-protein coupled receptor 109; G-protein coupled receptor HM74; hydroxycarboxylic acid receptor 2; interferon-gamma inducible gene, Puma-g; niacin receptor 1; nicotinic acid receptor; putative seven transmembrane spanning receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:80885); (R-MMU-3296197); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11745392;12563315;12646212;15929991;16322797;19141678;21183079;30084848;34428180;38761195", "class_list": "", "function": "(D)-beta-hydroxybutyrate ((D)-beta-OHB) specifically activates PUMA-G/HM74a at concentrations observed in serum during fasting; (D)-beta-OHB inhibits mouse adipocyte lipolysis in a PUMA-G-dependent manner, [RefSeq, PubMed]; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis., [UniProtKB, PubMed]; Clostridium butyricum upregulates GPR109A/AMPK/PGC-1alpha and ameliorates acute pancreatitis-associated intestinal barrier injury in mice. Publication Status: Online-Only, [RefSeq, PubMed]; GPR109A mediates nicotinic acid-induced flushing, an effect which involves release of PGE(2) and PGD(2), most likely from immune cells of the skin, [RefSeq, PubMed]; PUMA-G is highly expressed in adipose tissue and is a nicotinic acid receptor, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005525 GTP binding;GO:0001614 purinergic nucleotide receptor activity;GO:0070553 nicotinic acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0006915 apoptotic process;GO:0050995 negative regulation of lipid catabolic process;GO:0033031 positive regulation of neutrophil apoptotic process;GO:0070165 positive regulation of adiponectin secretion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EP66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU19-1", "uniprot_id": [ { "id": "HAOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU19", "type": "external" } ], "mass": 41001.0, "length": 370, "protein_name": "2-Hydroxyacid oxidase 1", "gene_name": "Hao1", "organism": "Mouse", "refseq_name": "2-Hydroxyacid oxidase 1", "refseq_ac": [ { "id": "NP_034533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034533", "type": "external" } ], "gene_names_uniprotkb": "Hao1", "gene_names_refseq": "GOX; Gox1; Hao-1; Hao1", "protein_names_uniprotkb": "2-Hydroxyacid oxidase 1; 1.1.3.15; 1.2.3.5; GOX; Glycolate oxidase; Glyoxylate oxidase; HAOX1", "protein_names_refseq": "2-Hydroxyacid oxidase 1; HAOX1; glycolate oxidase 1; glyoxylate oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:15112); (R-MMU-389661); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17242355;21183079;23806337;26655602;34428180;35953025;37453647;9891009", "class_list": "", "function": "Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:9891009). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (By similarity). Can also catalyze the oxidation glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate (By similarity). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:9891009)., [UniProtKB, PubMed, UniProtKB]; Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion., [RefSeq, PubMed]; HAO1 negatively regulates liver macrophage activation via the NF-kappaB pathway in alcohol-associated liver disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0010181 FMN binding;GO:0003973 (S)-2-hydroxy-acid oxidase activity;GO:0047969 glyoxylate oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006545 glycine biosynthetic process;GO:0006979 response to oxidative stress;GO:0001561 fatty acid alpha-oxidation;GO:0046296 glycolate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WU19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61191-1", "uniprot_id": [ { "id": "HCFC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61191", "type": "external" } ], "mass": 210437.0, "length": 2045, "protein_name": "Host cell factor 1", "gene_name": "Hcfc1", "organism": "Mouse", "refseq_name": "host cell factor 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_032250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032250", "type": "external" } ], "gene_names_uniprotkb": "Hcfc1", "gene_names_refseq": "HCF1; HCF; Hcfc1", "protein_names_uniprotkb": "Host cell factor 1; C1 factor; HCF-1; HCF", "protein_names_refseq": "VP16 accessory protein; host cell factor 1 isoform 2 precursor; host cell factor 1", "tax_id": 10090, "disease": "methylmalonic acidemia and homocysteinemia cblX type (Disease Ontology:DOID:0111814); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:15161); (R-MMU-3214847); (R-MMU-5689603); (R-MMU-9772755)", "pathway_count": 4, "publication_count": 56, "publication_id_list": "10.3389/fragi.2021.757801;16452088;18585351;19224205;20173027;21158410;21183079;21540332;21606357;21750661;22517741;22645316;22872234;23443134;23806337;24129315;25428506;26192747;27669760;29237092;29562282;30059200;30084848;30779550;31219806;31227231;31616917;32152506;32782141;32848054;33725478;34105348;34203471;34428180;34678516;34887587;35013307;35469018;35820727;35822049;36064721;36084651;36288343;36692302;36852467;37507081;39627609;39927985;40021952;40128797;40754593;40885482;40997131;9285407;9334261;9990006", "class_list": "", "function": "Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation., [RefSeq, PubMed]; Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]., [RefSeq]; Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (By similarity). Involved in control of the cell cycle (PubMed:9334261, PubMed:9990006). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 118, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 118, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 118, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 118, "binding_glycan_count": 0, "secondary_ac_list": "B1AUX1;Q684R1;Q7TSB0;Q8C2D0;Q9QWH2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0019046 release from viral latency;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 17.6, "record_id": "Q61191-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHD8-1", "uniprot_id": [ { "id": "HORN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHD8", "type": "external" } ], "mass": 247587.0, "length": 2496, "protein_name": "Hornerin", "gene_name": "Hrnr", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hrnr", "gene_names_refseq": "", "protein_names_uniprotkb": "Hornerin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:68723); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11572870;12642627;21750661;24129315;26495903;34428180", "class_list": "", "function": "Component of the epidermal cornified cell envelopes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0001533 cornified envelope;GO:0036457 keratohyalin granule", "go_biological_process": "GO:0031424 keratinization;GO:0061436 establishment of skin barrier;GO:0002244 hematopoietic progenitor cell differentiation;GO:0043163 cell envelope organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VHD8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U487-1", "uniprot_id": [ { "id": "HECD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U487", "type": "external" } ], "mass": 97347.0, "length": 861, "protein_name": "E3 ubiquitin-protein ligase HECTD3", "gene_name": "Hectd3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase HECTD3", "refseq_ac": [ { "id": "NP_780453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780453", "type": "external" } ], "gene_names_uniprotkb": "Hectd3", "gene_names_refseq": "1700064K09Rik; Hectd3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HECTD3; 2.3.2.26; HECT domain-containing protein 3; HECT-type E3 ubiquitin transferase HECTD3", "protein_names_refseq": "E3 ubiquitin-protein ligase HECTD3; HECT domain-containing protein 3; HECT-type E3 ubiquitin transferase HECTD3; probable E3 ubiquitin-protein ligase HECTD3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76608); (R-MMU-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18821010;29920190;33037313;33109704;34428180;35820727", "class_list": "", "function": "Deficiency of the E3 ligase gene Hectd3 remarkably increased host defense against infection by intracellular bacteria Francisella novicida, Mycobacterium, and Listeria by limiting bacterial dissemination. In the absence of HECTD3, type I IFN response was impaired during bacterial infection both in vivo and in vitro., [RefSeq, PubMed]; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP (By similarity). Also mediates ubiquitination of STX8., [UniProtKB, UniProtKB, PubMed]; Syntaxin 8 and HECTd3 have similar subcellular localization., [RefSeq, PubMed]; The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUL1;Q3TN76;Q641P3;Q8BQ74;Q8R1L6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U487-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V016-1", "uniprot_id": [ { "id": "HIPK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V016", "type": "external" } ], "mass": 69279.0, "length": 616, "protein_name": "Homeodomain-interacting protein kinase 4", "gene_name": "Hipk4", "organism": "Mouse", "refseq_name": "homeodomain-interacting protein kinase 4", "refseq_ac": [ { "id": "NP_001028487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028487", "type": "external" } ], "gene_names_uniprotkb": "Hipk4; Gm162", "gene_names_refseq": "Gm162; Hipk4", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 4; 2.7.11.1", "protein_names_refseq": "homeodomain-interacting protein kinase 4", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:233020)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18022393;21183079", "class_list": "", "function": "Protein kinase that phosphorylates murine TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8R3X8;B9EJV5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0035173 histone kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0046777 protein autophosphorylation;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3V016-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EBG6-1", "uniprot_id": [ { "id": "HSPB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5EBG6", "type": "external" } ], "mass": 17521.0, "length": 162, "protein_name": "Heat shock protein beta-6", "gene_name": "Hspb6", "organism": "Mouse", "refseq_name": "heat shock protein beta-6 isoform 1", "refseq_ac": [ { "id": "NP_001012401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012401", "type": "external" } ], "gene_names_uniprotkb": "Hspb6; Gm479", "gene_names_refseq": "Gm479; Hsp20; Hspb6", "protein_names_uniprotkb": "Heat shock protein beta-6; HspB6", "protein_names_refseq": "cardiac heat shock protein p20; heat shock protein beta-6 isoform 1; heat shock protein beta-6; heat shock protein, alpha-crystallin-related, B6", "tax_id": 10090, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093)", "pathway": " (mmu:243912)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14615292;15105294;20854253;21334344;22260692;23713735;31210321;32218573;33339131;36288343;37507081;38237739;38466834", "class_list": "", "function": "HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway., [RefSeq, PubMed]; HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture., [RefSeq, PubMed]; Hsp20-S10F mice treated with probenecid had decreased mortality, hypertrophy, TRPV2 expression and molecular parameters of heart failure. Publication Status: Online-Only, [RefSeq, PubMed]; Identification and characterization of a cardiac isoform of p20 associated with beta-adrenergic signaling in adult cardiomyocytes., [RefSeq, PubMed]; Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy., [RefSeq, PubMed]; Recombinant mouse Hsp20 translocates to and interacts with actin cytoskeleton in response to isoproterenol stimulation and prevents ss-agonist-induced apoptosis in adult rat cardiomyocytes., [RefSeq, PubMed]; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity., [UniProtKB, UniProtKB]; The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045766 positive regulation of angiogenesis;GO:0006457 protein folding;GO:0009408 response to heat;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5EBG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPR6-1", "uniprot_id": [ { "id": "IBTK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPR6", "type": "external" } ], "mass": 149569.0, "length": 1352, "protein_name": "Inhibitor of Bruton tyrosine kinase", "gene_name": "Ibtk", "organism": "Mouse", "refseq_name": "inhibitor of Bruton tyrosine kinase isoform 1", "refseq_ac": [ { "id": "NP_001074751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074751", "type": "external" } ], "gene_names_uniprotkb": "Ibtk; Kiaa1417", "gene_names_refseq": "5430411K16Rik; BTKI; Ibtk; mKIAA1417", "protein_names_uniprotkb": "Inhibitor of Bruton tyrosine kinase; IBtk", "protein_names_refseq": "inhibitor of Bruton tyrosine kinase isoform 1; inhibitor of Bruton tyrosine kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:108837)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;19144319;21183079;21750661;30975981;31219806;32019112;34428180;35820727", "class_list": "", "function": "Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; IBTK Haploinsufficiency Affects the Tumor Microenvironment of Myc-Driven Lymphoma in E-myc Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Ibtk sustains the oncogenic activity of Myc by inhibiting apoptosis of murine pre-cancerous B cells, as a cell-specific mechanism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHE9;Q3V3X0;Q8BVL7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030292 protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6ZPR6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1H0-1", "uniprot_id": [ { "id": "HOP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1H0", "type": "external" } ], "mass": 8282.0, "length": 73, "protein_name": "Homeodomain-only protein", "gene_name": "Hopx", "organism": "Mouse", "refseq_name": "homeodomain-only protein", "refseq_ac": [ { "id": "NP_001153372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153372", "type": "external" } ], "gene_names_uniprotkb": "Hopx; Hod; Hop; Ob1", "gene_names_refseq": "1110018K11Rik; 1200015P04Rik; 2300002F06Rik; Cameo; Hdop; Hod; Hopx; Hop; Ob1; Obl; Toto", "protein_names_uniprotkb": "Homeodomain-only protein; Homeobox-only protein; Odd homeobox protein 1; mOB1", "protein_names_refseq": "homeobox only domain; homeobox-only protein; homeodomain-only protein; mOB1; odd homeobox 1; odd homeobox protein 1", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:74318)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12297045;12297046;12975471;14516659", "class_list": "", "function": "Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Data show that Hop can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity and can form a complex that includes HDAC2, [RefSeq, PubMed]; HOP is highly expressed in the developing heart, dependent on the cardiac-restricted homeodomain protein Nkx2.5. Mice homozygous for a HOP null allele segregate into two phenotypic classes characterized by an excess or deficiency of cardiac myocytes., [RefSeq, PubMed]; Inactivation of Hop in mice by homologous recombination results in a partially penetrant embryonic lethal phenotype with severe developmental cardiac defects involving the myocardium., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1N5;Q8CJ22", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0035033 histone deacetylase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0048286 lung alveolus development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R1H0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYW4-1", "uniprot_id": [ { "id": "HDHD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYW4", "type": "external" } ], "mass": 28027.0, "length": 251, "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 3", "gene_name": "Hdhd3", "organism": "Mouse", "refseq_name": "haloacid dehalogenase-like hydrolase domain-containing protein 3", "refseq_ac": [ { "id": "NP_077219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077219", "type": "external" } ], "gene_names_uniprotkb": "Hdhd3", "gene_names_refseq": "2810435D12Rik; Hdhd3", "protein_names_uniprotkb": "Haloacid dehalogenase-like hydrolase domain-containing protein 3", "protein_names_refseq": "haloacid dehalogenase-like hydrolase domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72748)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23576753;23806337", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CYW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0S9-1", "uniprot_id": [ { "id": "HINT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0S9", "type": "external" } ], "mass": 17320.0, "length": 163, "protein_name": "Adenosine 5'-monophosphoramidase HINT2", "gene_name": "Hint2", "organism": "Mouse", "refseq_name": "adenosine 5'-monophosphoramidase HINT2 precursor", "refseq_ac": [ { "id": "NP_081147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081147", "type": "external" } ], "gene_names_uniprotkb": "Hint2", "gene_names_refseq": "1190005L05Rik; Hint2", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT2; 3.9.1.-; HINT-2; HINT-3; Histidine triad nucleotide-binding protein 2, mitochondrial", "protein_names_refseq": "HINT-2; HINT-3; adenosine 5'-monophosphoramidase HINT2 precursor; adenosine 5'-monophosphoramidase HINT2; histidine triad nucleotide-binding protein 2, mitochondrial", "tax_id": 10090, "disease": "Gamstorp-Wohlfart syndrome (Disease Ontology:DOID:0050526)", "pathway": " (mmu:68917)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "22961760;23576753;23806337;24010670;31900976;34914018;36288343;36722640;37507081;38546629", "class_list": "", "function": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (By similarity). May be involved in steroid biosynthesis (By similarity). May play a role in apoptosis (By similarity)., [UniProtKB, UniProtKB]; HINT2 deficiency deteriorates oxidative stress in a mouse model of myocardial infarction., [RefSeq, PubMed]; HINT2 protects against pressure overload-induced cardiac remodelling through mitochondrial pathways., [RefSeq, PubMed]; Hint2/HINT2 positively regulates mitochondrial lipid metabolism and respiration and glucose homeostasis., [RefSeq, PubMed]; Overexpression of the histidine triad nucleotide-binding protein 2 protects cardiac function in the adult mice after acute myocardial infarction., [RefSeq, PubMed]; Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of the mitochondrial protein Hint2 on intracellular Ca(2+) dynamics, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006915 apoptotic process;GO:0016042 lipid catabolic process;GO:0006694 steroid biosynthetic process;GO:2000757 negative regulation of peptidyl-lysine acetylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D0S9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERZ0-1", "uniprot_id": [ { "id": "HEMGN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERZ0", "type": "external" } ], "mass": 55043.0, "length": 503, "protein_name": "Hemogen", "gene_name": "Hemgn", "organism": "Mouse", "refseq_name": "hemogen", "refseq_ac": [ { "id": "NP_444379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444379", "type": "external" } ], "gene_names_uniprotkb": "Hemgn; Ndr", "gene_names_refseq": "4921524M03Rik; EDAG; Hemgn; Hgn; mNDR", "protein_names_uniprotkb": "Hemogen; Hemopoietic gene protein; Negative differentiation regulator protein; mNDR", "protein_names_refseq": "hemogen; hemopoietic gene protein; negative differentiation regulator protein; nuclear protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:93966)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11404085;14648837;17690693;20393131;21183079;30084848", "class_list": "", "function": "Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis, [RefSeq, PubMed]; EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment, [RefSeq, PubMed]; HOXB4 binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units., [RefSeq, PubMed]; Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AVH8;Q3TAE6;Q80YT2;Q8CF29", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0045667 regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ERZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK92-1", "uniprot_id": [ { "id": "HSPB8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK92", "type": "external" } ], "mass": 21533.0, "length": 196, "protein_name": "Heat shock protein beta-8", "gene_name": "Hspb8", "organism": "Mouse", "refseq_name": "heat shock protein beta-8", "refseq_ac": [ { "id": "NP_109629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109629", "type": "external" } ], "gene_names_uniprotkb": "Hspb8; Cryac; Hsp22", "gene_names_refseq": "Cryac; D5Ucla4; E2IG1; H11K; H11; HSP20-like; HSP22; Hspb8", "protein_names_uniprotkb": "Heat shock protein beta-8; Alpha-crystallin C chain; HspB8; Small stress protein-like protein HSP22", "protein_names_refseq": "alpha-crystallin C chain; crystallin, alpha C; heat shock 27kDa protein 8; heat shock protein 20-like protein; heat shock protein 8; heat shock protein beta-8; small stress protein-like protein HSP22", "tax_id": 10090, "disease": "myofibrillar myopathy 13 with rimmed vacuoles (Disease Ontology:DOID:0051045); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206)", "pathway": " (mmu:80888); (R-MMU-3371571)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11133685;11342557;17242355;19131326;20060297;21183079;24129315;28135057;30084848;31219806;34428180;35958024;35984892;36288343;37399610;37522952", "class_list": "", "function": "HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation. Publication Status: Online-Only, [RefSeq, PubMed]; HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy., [RefSeq, PubMed]; HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke., [RefSeq, PubMed]; Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle (PubMed:20060297). Displays temperature-dependent chaperone activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0034620 cellular response to unfolded protein;GO:1905337 positive regulation of aggrephagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JK92-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB07-1", "uniprot_id": [ { "id": "IFT46_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB07", "type": "external" } ], "mass": 34054.0, "length": 301, "protein_name": "Intraflagellar transport protein 46 homolog", "gene_name": "Ift46", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 46 homolog", "refseq_ac": [ { "id": "NP_076320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076320", "type": "external" } ], "gene_names_uniprotkb": "Ift46", "gene_names_refseq": "1500035H01Rik; Ift46; c11orf2", "protein_names_uniprotkb": "Intraflagellar transport protein 46 homolog", "protein_names_refseq": "intraflagellar transport 46 homolog; intraflagellar transport protein 46 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76568); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10873569;17312020;17720815;18852297;19253336;21183079;21289087;21750661;23810713;25340710;25860617", "class_list": "", "function": "Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis., [UniProtKB, PubMed, PubMed]; The ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z06;Q9JHT1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0015031 protein transport;GO:0031647 regulation of protein stability;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DB07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKE9-1", "uniprot_id": [ { "id": "IFT74_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKE9", "type": "external" } ], "mass": 69301.0, "length": 600, "protein_name": "Intraflagellar transport protein 74 homolog", "gene_name": "Ift74", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 74 homolog isoform 2", "refseq_ac": [ { "id": "NP_001277497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277497", "type": "external" } ], "gene_names_uniprotkb": "Ift74; Ccdc2; Cmg1", "gene_names_refseq": "1700029H06Rik; Ccdc2; Cmg1; Ift74; b2b796Clo", "protein_names_uniprotkb": "Intraflagellar transport protein 74 homolog; CMG-1; Capillary morphogenesis gene 1 protein; Coiled-coil domain-containing protein 2", "protein_names_refseq": "capillary morphogenesis gene 1 protein; capillary morphogenesis protein 1; coiled-coil domain-containing protein 2; intraflagellar transport protein 74 homolog isoform 2; intraflagellar transport protein 74 homolog", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Joubert syndrome (Disease Ontology:DOID:0050777); Bardet-Biedl syndrome 22 (Disease Ontology:DOID:0081011); spermatogenic failure 58 (Disease Ontology:DOID:0112352)", "pathway": " (mmu:67694); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16705683;16775004;17525332;17971504;21750661;23810713;24129315;25428507;25605945;31004481;31219806;37315079", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). Essential for flagellogenesis during spermatogenesis (PubMed:31004481)., [UniProtKB, UniProtKB, PubMed]; IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. Publication Status: Online-Only, [RefSeq, PubMed]; Ift74 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in micedagger., [RefSeq, PubMed]; Results identify a cDNA encoding the mouse ortholog of capillary morphogenesis gene (CMG)-1, and suggest that CMG-1 may play a role in the transcriptional regulation of the cyclin D2 gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AWG2;Q80ZI3;Q9CSY1;Q9CUS0;Q9D9T5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BKE9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true } ]