[ { "uniprot_canonical_ac": "Q8BGE9-1", "uniprot_id": [ { "id": "RL3R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGE9", "type": "external" } ], "mass": 51573.0, "length": 472, "protein_name": "Relaxin-3 receptor 1", "gene_name": "Rxfp3", "organism": "Mouse", "refseq_name": "relaxin-3 receptor 1", "refseq_ac": [ { "id": "NP_848832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848832", "type": "external" } ], "gene_names_uniprotkb": "Rxfp3; Rln3r1; Salpr", "gene_names_refseq": "GPCR135; Rln3r1; Rxfp3; Salpr", "protein_names_uniprotkb": "Relaxin-3 receptor 1; G protein-coupled receptor SALPR homolog; RLN3 receptor 1; Relaxin family peptide receptor 3", "protein_names_refseq": "G-protein coupled receptor SALPR; RLN3 receptor 1; g protein-coupled receptor SALPR homolog; relaxin-3 receptor 1; relaxin-3/INSL7 receptor 1; somatostatin and angiotensin-like peptide receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:239336); (R-MMU-418594); (R-MMU-444821)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15351514;20737598", "class_list": "", "function": "A distinct pattern of expression in brain, spinal cord, and dorsal root ganglia during development and in the mature brain hint at important functions of SALPR for differentiation and maintenance of the nervous system.(SALPR PROTEIN, MOUSE), [RefSeq, PubMed]; Data provide evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate 'behavioral state' and an array of circuits involved in arousal, stress, affect, and cognition., [RefSeq, PubMed]; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHT7-1", "uniprot_id": [ { "id": "RGP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHT7", "type": "external" } ], "mass": 42498.0, "length": 391, "protein_name": "RAB6A-GEF complex partner protein 2", "gene_name": "Rgp1", "organism": "Mouse", "refseq_name": "RAB6A-GEF complex partner protein 2", "refseq_ac": [ { "id": "NP_766454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766454", "type": "external" } ], "gene_names_uniprotkb": "Rgp1; Kiaa0258", "gene_names_refseq": "1110029E03Rik; F730001J03; Rgp1; mKIAA0258", "protein_names_uniprotkb": "RAB6A-GEF complex partner protein 2; Retrograde Golgi transport protein RGP1 homolog", "protein_names_refseq": "RAB6A-GEF complex partner protein 2; RGP1 retrograde golgi transport homolog; retrograde Golgi transport protein RGP1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:242406); (R-MMU-6811438); (R-MMU-6811440); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "31599954", "class_list": "", "function": "The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AWI4;Q6ZQF1", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0042147 retrograde transport, endosome to Golgi;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJU9-1", "uniprot_id": [ { "id": "RF1ML_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJU9", "type": "external" } ], "mass": 42248.0, "length": 373, "protein_name": "Peptide chain release factor 1-like, mitochondrial", "gene_name": "Mtrf1l", "organism": "Mouse", "refseq_name": "peptide chain release factor 1-like, mitochondrial precursor", "refseq_ac": [ { "id": "NP_780583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780583", "type": "external" } ], "gene_names_uniprotkb": "Mtrf1l", "gene_names_refseq": "9130004K12Rik; Mtrf1l", "protein_names_uniprotkb": "Peptide chain release factor 1-like, mitochondrial; Mitochondrial translational release factor 1-like", "protein_names_refseq": "peptide chain release factor 1-like, mitochondrial precursor; peptide chain release factor 1-like, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:108853); (R-MMU-5419276)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003747 translation release factor activity;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070126 mitochondrial translational termination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BJU9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP97-1", "uniprot_id": [ { "id": "RHBD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP97", "type": "external" } ], "mass": 40934.0, "length": 385, "protein_name": "Rhomboid domain-containing protein 3", "gene_name": "Rhbdd3", "organism": "Mouse", "refseq_name": "rhomboid domain-containing protein 3 isoform b", "refseq_ac": [ { "id": "NP_001277420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277420", "type": "external" } ], "gene_names_uniprotkb": "Rhbdd3", "gene_names_refseq": "Ptag; Rhbdd3", "protein_names_uniprotkb": "Rhomboid domain-containing protein 3", "protein_names_refseq": "pituitary-derived proapoptotic; rhomboid domain-containing protein 3 isoform b; rhomboid domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:279766)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23610400;24859449", "class_list": "", "function": "Report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the activation of dendritic cells and production of interleukin 6 (IL-6) triggered by Toll-like receptors, [RefSeq, PubMed]; Rhbdd3 is a feedback inhibitor of TLR3-triggered NK cell activation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTD2;B7ZNK0;Q3U0Y4;Q5SUT5;Q5SUT6;Q5SUT7", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0000165 MAPK cascade;GO:0045732 positive regulation of protein catabolic process;GO:0050708 regulation of protein secretion;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BP97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPM6-1", "uniprot_id": [ { "id": "RIC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPM6", "type": "external" } ], "mass": 40283.0, "length": 367, "protein_name": "Protein RIC-3", "gene_name": "Ric3", "organism": "Mouse", "refseq_name": "protein RIC-3 isoform a precursor", "refseq_ac": [ { "id": "NP_001033713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033713", "type": "external" } ], "gene_names_uniprotkb": "Ric3", "gene_names_refseq": "E130307J04Rik; Ric3", "protein_names_uniprotkb": "Protein RIC-3; Resistant to inhibitor of cholinesterase 3", "protein_names_refseq": "protein RIC-3 isoform a precursor; protein RIC-3; resistance to inhibitors of cholinesterase 3 homolog; resistant to inhibitor of cholinesterase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:320360)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12821669;19812337;20668195;21750661;27129882;32179243;32204458", "class_list": "", "function": "In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport., [RefSeq, PubMed]; Molecular chaperone which promotes the proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) nicotinic acetylcholine receptor (PubMed:19812337, PubMed:32204458). Promotes the proper subunit assembly and cell surface expression of alpha-8 (CHRNA8) nicotinic acetylcholine receptor (By similarity). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation., [RefSeq, PubMed]; Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression. Publication Status: Online-Only, [RefSeq, PubMed]; Why Does Knocking Out NACHO, But Not RIC3, Completely Block Expression of alpha7 Nicotinic Receptors in Mouse Brain? Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCM7;Q8C4G2", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007271 synaptic transmission, cholinergic;GO:2000010 positive regulation of protein localization to cell surface;GO:0034394 protein localization to cell surface;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BPM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVY0-1", "uniprot_id": [ { "id": "RL1D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVY0", "type": "external" } ], "mass": 50421.0, "length": 452, "protein_name": "Ribosomal L1 domain-containing protein 1", "gene_name": "Rsl1d1", "organism": "Mouse", "refseq_name": "ribosomal L1 domain-containing protein 1", "refseq_ac": [ { "id": "NP_079822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079822", "type": "external" } ], "gene_names_uniprotkb": "Rsl1d1", "gene_names_refseq": "2410005K20Rik; Rsl1d1; pBK1", "protein_names_uniprotkb": "Ribosomal L1 domain-containing protein 1", "protein_names_refseq": "ribosomal L1 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66409)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;21952136;25428506;25605945;26686419;28135057;30779550;34428180;34887587;35820727;35940221", "class_list": "", "function": "Conclusively, both ribosomal L1 domain and Lys-rich region of CSIG are critical for CSIG to act as a regulator of cell proliferation and cellular senescence., [RefSeq, PubMed]; RSL1D1 modulates cell senescence and proliferation via regulation of PPARgamma mRNA stability., [RefSeq, PubMed]; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K235", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005929 cilium;GO:0005694 chromosome", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0042981 regulation of apoptotic process;GO:2000772 regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BVY0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBG9-1", "uniprot_id": [ { "id": "RN170_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBG9", "type": "external" } ], "mass": 33414.0, "length": 286, "protein_name": "E3 ubiquitin-protein ligase RNF170", "gene_name": "Rnf170", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF170 isoform 2", "refseq_ac": [ { "id": "NP_001344221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001344221", "type": "external" } ], "gene_names_uniprotkb": "Rnf170", "gene_names_refseq": "6720407G21Rik; Rnf170", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF170; 2.3.2.27; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF170 isoform 2; E3 ubiquitin-protein ligase RNF170; RING-type E3 ubiquitin transferase RNF170", "tax_id": 10090, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal dominant sensory ataxia 1 (Disease Ontology:DOID:0111170); hereditary spastic paraplegia 85 (Disease Ontology:DOID:0112345); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:77733)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21610068;21750661;31076723", "class_list": "", "function": "E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3 (PubMed:31076723)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H618;Q3U796;Q78QX6;Q8C8S1;Q8C9I0;Q8K0H6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0019233 sensory perception of pain;GO:0009266 response to temperature stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CBG9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CD15-1", "uniprot_id": [ { "id": "RIOX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CD15", "type": "external" } ], "mass": 53517.0, "length": 465, "protein_name": "Ribosomal oxygenase 2", "gene_name": "Riox2", "organism": "Mouse", "refseq_name": "ribosomal oxygenase 2", "refseq_ac": [ { "id": "NP_080186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080186", "type": "external" } ], "gene_names_uniprotkb": "Riox2; Mina53; Mina", "gene_names_refseq": "1810047J07Rik; 2410057H13Rik; 3830408E23Rik; Mina; Riox2", "protein_names_uniprotkb": "Ribosomal oxygenase 2; 1.14.11.79; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; Histone lysine demethylase MINA; MYC-induced nuclear antigen", "protein_names_refseq": "MYC-induced nuclear antigen; bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; histone lysine demethylase MINA; myc induced nuclear antigen; ribosomal oxygenase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67014); (R-MMU-3214842); (R-MMU-9629569)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "16533354;18299400;19224205;19561615;20173027;20484733;21750661;21952136;23748603;25282476;25428506;25428507;25605945;25669985;27802388;28967702;30084848;31219806;34428180;35820727", "class_list": "", "function": "Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression., [RefSeq, PubMed]; Mina53 is prominently expressed in proliferating, undifferentiated spermatogonia, and plays a role in cell proliferation from the spermatogonial stage to the meiotic prophase in spermatogenesis, but not in meiotic divisions per se., [RefSeq, PubMed]; Mina53 plays a role in the allergic response to inhaled allergens, possibly through controlling IL-4 production., [RefSeq, PubMed]; Mina: a Th2 response regulator meets TGFbeta. Review article, [RefSeq, PubMed]; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Results demonstrate the TGFbeta signaling pathway plays a critical role in regulating Mina expression and SNP rs4191790 controls heritable variation in Mina expression level, raising important questions regarding the evolution of an allele that uncouples Mina expression from the TGFbeta signaling pathway., [RefSeq, PubMed]; Results suggest that mdig may contribute to silica-induced lung fibrosis by altering the balance between Th17 and Treg cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZX1;Q9CQ03", "ec_number_list": [ { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" }, { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CD15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFV9-1", "uniprot_id": [ { "id": "RIFK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFV9", "type": "external" } ], "mass": 17437.0, "length": 155, "protein_name": "Riboflavin kinase", "gene_name": "Rfk", "organism": "Mouse", "refseq_name": "riboflavin kinase", "refseq_ac": [ { "id": "NP_062310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062310", "type": "external" } ], "gene_names_uniprotkb": "Rfk", "gene_names_refseq": "0610038L10Rik; KOI-4; Rfk", "protein_names_uniprotkb": "Riboflavin kinase; 2.7.1.26; ATP:riboflavin 5'-phosphotransferase; Flavokinase; KOI-4", "protein_names_refseq": "ATP:riboflavin 5'-phosphotransferase; flavokinase; riboflavin kinase", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:54391); (R-MMU-196843)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19641494;28402850", "class_list": "", "function": "Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity)., [UniProtKB, UniProtKB]; Knockdown of Rfk combined with a riboflavin-deficient diet altered the CRY levels in mouse liver and the expression profiles of clock and clock-controlled genes (especially those related to metabolism including glucose homeostasis)., [RefSeq, PubMed]; Results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35471;O35472;Q9CQ95", "ec_number_list": [ { "id": "2.7.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.26", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008531 riboflavin kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0033864 positive regulation of NAD(P)H oxidase activity;GO:0072593 reactive oxygen species metabolic process;GO:0009231 riboflavin biosynthetic process;GO:0009398 FMN biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFV9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIK8-1", "uniprot_id": [ { "id": "RFWD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIK8", "type": "external" } ], "mass": 84312.0, "length": 774, "protein_name": "E3 ubiquitin-protein ligase RFWD3", "gene_name": "Rfwd3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RFWD3", "refseq_ac": [ { "id": "NP_666330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666330", "type": "external" } ], "gene_names_uniprotkb": "Rfwd3; Rnf201", "gene_names_refseq": "Rfwd3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RFWD3; 2.3.2.27; RING finger and WD repeat domain-containing protein 3; RING finger protein 201", "protein_names_refseq": "E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3", "tax_id": 10090, "disease": "Fanconi anemia complementation group W (Disease Ontology:DOID:0060978)", "pathway": " (mmu:234736)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19224205;20173027;25605945;28691929;31219806;34418053;34428180;36158256", "class_list": "", "function": "E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA)., [UniProtKB, UniProtKB]; RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/beta-catenin signalling pathways in hepatocellular carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV90;Q6PJA8;Q8R2T9;Q8R351", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0002039 p53 binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016605 PML body;GO:0035861 site of double-strand break", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CIK8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2M0-1", "uniprot_id": [ { "id": "RM38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2M0", "type": "external" } ], "mass": 45030.0, "length": 380, "protein_name": "Large ribosomal subunit protein mL38", "gene_name": "Mrpl38", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL38 precursor", "refseq_ac": [ { "id": "NP_077139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077139", "type": "external" } ], "gene_names_uniprotkb": "Mrpl38", "gene_names_refseq": "1110036N21Rik; 4733401F03Rik; MRP-L3; Mrpl38; Rpml3", "protein_names_uniprotkb": "Large ribosomal subunit protein mL38; 39S ribosomal protein L38, mitochondrial; L38mt; MRP-L38", "protein_names_refseq": "39S ribosomal protein L38, mitochondrial; L38mt; MRP-L38; large ribosomal subunit protein mL38 precursor; large ribosomal subunit protein mL38; ribosomal protein, mitochondrial, L3", "tax_id": 10090, "disease": "", "pathway": " (mmu:60441); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A869;Q3TXY6;Q8BTZ1;Q99LM1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2M0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2Y7-1", "uniprot_id": [ { "id": "RM47_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2Y7", "type": "external" } ], "mass": 29726.0, "length": 252, "protein_name": "Large ribosomal subunit protein uL29m", "gene_name": "Mrpl47", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL29m", "refseq_ac": [ { "id": "NP_083293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083293", "type": "external" } ], "gene_names_uniprotkb": "Mrpl47", "gene_names_refseq": "4833424P18Rik; CGI-204; Gm9859; L47mt; MRP-L47; MTF/L47; Mrpl47; NCM1", "protein_names_uniprotkb": "Large ribosomal subunit protein uL29m; 39S ribosomal protein L47, mitochondrial; L47mt; MRP-L47", "protein_names_refseq": "39S ribosomal protein L47, mitochondrial; large ribosomal subunit protein uL29m; metanephros-derived tubulogenic factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74600); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "14633119", "class_list": "", "function": "Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BRG1/brm-associated factor 53A (also known as BAF complex 53 kDa subunit protein A in humans) in a tail-to-tail orientation. [provided by RefSeq, Jul 2008]., [RefSeq]; Novel molecule in developing kidney that is capable of modulating ureteric bud branching and kidney differentiation. [Metanephros-derived tubulogenic factor], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0U2;Q8CHZ6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2S1-1", "uniprot_id": [ { "id": "RPKL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2S1", "type": "external" } ], "mass": 60193.0, "length": 544, "protein_name": "Ribosomal protein S6 kinase-like 1", "gene_name": "Rps6kl1", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase-like 1 isoform 2", "refseq_ac": [ { "id": "NP_666356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666356", "type": "external" } ], "gene_names_uniprotkb": "Rps6kl1", "gene_names_refseq": "A830084F09Rik; Rps6kl1", "protein_names_uniprotkb": "Ribosomal protein S6 kinase-like 1; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase-like 1 isoform 2", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:238323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1D4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2S1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R323-1", "uniprot_id": [ { "id": "RFC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R323", "type": "external" } ], "mass": 40526.0, "length": 356, "protein_name": "Replication factor C subunit 3", "gene_name": "Rfc3", "organism": "Mouse", "refseq_name": "replication factor C subunit 3 isoform 1", "refseq_ac": [ { "id": "NP_081285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081285", "type": "external" } ], "gene_names_uniprotkb": "Rfc3", "gene_names_refseq": "2810416I22Rik; 38kDa; Recc3; Rfc3", "protein_names_uniprotkb": "Replication factor C subunit 3; A1 38 kDa subunit; Activator 1 38 kDa subunit; Activator 1 subunit 3; RF-C 38 kDa subunit; RFC38; Replication factor C 38 kDa subunit", "protein_names_refseq": "A1 38 kDa subunit; RF-C 38 kDa subunit; RFC38; activator 1 38 kDa subunit; activator 1 subunit 3; replication factor C 38 kDa subunit; replication factor C 3; replication factor C subunit 3 isoform 1; replication factor C subunit 3; replication factor C, 38 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:69263); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174411); (R-MMU-176187); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6804756); (R-MMU-69091); (R-MMU-69473)", "pathway_count": 21, "publication_count": 3, "publication_id_list": "12406903;28528544;32640224", "class_list": "", "function": "A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells., [RefSeq, PubMed]; Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008094 ATP-dependent activity, acting on DNA;GO:0003689 DNA clamp loader activity;GO:0017116 single-stranded DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R323-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC34-1", "uniprot_id": [ { "id": "RPAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC34", "type": "external" } ], "mass": 68530.0, "length": 614, "protein_name": "Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2", "gene_name": "Rpap2", "organism": "Mouse", "refseq_name": "putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 isoform B", "refseq_ac": [ { "id": "NP_001156933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156933", "type": "external" } ], "gene_names_uniprotkb": "Rpap2", "gene_names_refseq": "Rpap2", "protein_names_uniprotkb": "Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2; 3.1.3.16; RNA polymerase II-associated protein 2", "protein_names_refseq": "putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 isoform B; putative RNA polymerase II subunit B1 CTD phosphatase Rpap2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231571); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;34428180;35975910;36852467;41018975", "class_list": "", "function": "Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:35975910)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLC8;Q3TSP8;Q3UKX0;Q8C7M5;Q8CBW8", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0043175 RNA polymerase core enzyme binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009301 snRNA transcription;GO:0036499 PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VC34-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEK2-1", "uniprot_id": [ { "id": "RHBD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEK2", "type": "external" } ], "mass": 39108.0, "length": 361, "protein_name": "Rhomboid domain-containing protein 2", "gene_name": "Rhbdd2", "organism": "Mouse", "refseq_name": "rhomboid domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_666114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666114", "type": "external" } ], "gene_names_uniprotkb": "Rhbdd2; Rhbdl7", "gene_names_refseq": "0610011L13Rik; Rhbdd2; Rhbdl7; Usmg1", "protein_names_uniprotkb": "Rhomboid domain-containing protein 2; Rhomboid-like protein 7", "protein_names_refseq": "rhomboid domain-containing protein 2 isoform 1; rhomboid domain-containing protein 2; rhomboid, veinlet-like 7; rhomboid-like protein 7; upregulated during skeletal muscle growth 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215160)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23386608", "class_list": "", "function": "RHBDD2 protein plays important roles in the development and normal function of the retina, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT71;Q4G0C4", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VEK2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YT2-1", "uniprot_id": [ { "id": "RN185_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YT2", "type": "external" } ], "mass": 20520.0, "length": 192, "protein_name": "E3 ubiquitin-protein ligase RNF185", "gene_name": "Rnf185", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF185 isoform 2", "refseq_ac": [ { "id": "NP_001277401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277401", "type": "external" } ], "gene_names_uniprotkb": "Rnf185", "gene_names_refseq": "Rnf185", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF185; 2.3.2.27; RING finger protein 185", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF185 isoform 2; E3 ubiquitin-protein ligase RNF185; RING-type E3 ubiquitin transferase RNF185", "tax_id": 10090, "disease": "", "pathway": " (mmu:193670); (R-MMU-382556); (R-MMU-9931269)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27485036;28273161;37831068", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (By similarity). Protects cells from ER stress-induced apoptosis (By similarity). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (By similarity). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity)., [UniProtKB, UniProtKB, PubMed]; RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWS3", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0043130 ubiquitin binding;GO:0044390 ubiquitin-like protein conjugating enzyme binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006914 autophagy;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91YT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920A5-1", "uniprot_id": [ { "id": "RISC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920A5", "type": "external" } ], "mass": 50965.0, "length": 452, "protein_name": "Retinoid-inducible serine carboxypeptidase", "gene_name": "Scpep1", "organism": "Mouse", "refseq_name": "retinoid-inducible serine carboxypeptidase precursor", "refseq_ac": [ { "id": "NP_083299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083299", "type": "external" } ], "gene_names_uniprotkb": "Scpep1; Risc", "gene_names_refseq": "2410018F01Rik; 4833411K15Rik; Risc; Scpep1", "protein_names_uniprotkb": "Retinoid-inducible serine carboxypeptidase; 3.4.16.-; Serine carboxypeptidase 1", "protein_names_refseq": "retinoid-inducible serine carboxypeptidase precursor; retinoid-inducible serine carboxypeptidase; retinoid-inducible serine caroboxypeptidase; retinoid-inducible serine caroboxypetidase; serine caroboxypeptidase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74617)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11447226;24586188;25428506;28011936;28234994;28528544;32152506;33725478;34428180;35820727;35984892;37828378;40997131", "class_list": "", "function": "In normal tissues the tandem of serine carboxypeptidases, Scpep1 and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in vascular wall and kidney homeostasis., [UniProtKB]; Our results define the biological role of mammalian serine carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together participate in the control of ET-1 regulation of vascular tone and hemodynamics Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9D625", "ec_number_list": [], "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0045776 negative regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q920A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q96DY5-1", "uniprot_id": [ { "id": "RN112_MOUSE", "url": "https://www.uniprot.org/uniprot/Q96DY5", "type": "external" } ], "mass": 71275.0, "length": 654, "protein_name": "RING finger protein 112", "gene_name": "Rnf112", "organism": "Mouse", "refseq_name": "RING finger protein 112 isoform 2", "refseq_ac": [ { "id": "NP_001277953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277953", "type": "external" } ], "gene_names_uniprotkb": "Rnf112; Bfp; Znf179", "gene_names_refseq": "Rnf112; ZNF179; Zfp179; bfp; neurolastin", "protein_names_uniprotkb": "RING finger protein 112; 2.3.2.27; Brain finger protein; Neurolastin; Zinc finger protein 179", "protein_names_refseq": "RING finger protein 112 isoform 2; brain finger protein; zinc finger protein 179", "tax_id": 10090, "disease": "", "pathway": " (mmu:22671)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21566658;24359566;26212327;26792191;26951452;27918959;28684796;33333713;9806830", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:21566658, PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage (PubMed:26792191, PubMed:26951452, PubMed:27918959). Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (PubMed:26212327)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Puralpha regulates the induction of Znf179 transcription during neuronal differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNS6;Q5NCN2;Q8JZT5;Q9Z328", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0051260 protein homooligomerization;GO:0030182 neuron differentiation;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q96DY5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N93-1", "uniprot_id": [ { "id": "RM16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N93", "type": "external" } ], "mass": 28804.0, "length": 251, "protein_name": "Large ribosomal subunit protein uL16m", "gene_name": "Mrpl16", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL16m precursor", "refseq_ac": [ { "id": "NP_079882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079882", "type": "external" } ], "gene_names_uniprotkb": "Mrpl16", "gene_names_refseq": "2310039D06Rik; Mrpl16", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16m; 39S ribosomal protein L16, mitochondrial; L16mt; MRP-L16", "protein_names_refseq": "39S ribosomal protein L16, mitochondrial; L16mt; MRP-L16; large ribosomal subunit protein uL16m precursor; large ribosomal subunit protein uL16m; mitochondiral ribosomal protein L16", "tax_id": 10090, "disease": "", "pathway": " (mmu:94063); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11279069;34428180;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N96-1", "uniprot_id": [ { "id": "RM01_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N96", "type": "external" } ], "mass": 37597.0, "length": 336, "protein_name": "Large ribosomal subunit protein uL1m", "gene_name": "Mrpl1", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL1m isoform 1", "refseq_ac": [ { "id": "NP_444388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444388", "type": "external" } ], "gene_names_uniprotkb": "Mrpl1", "gene_names_refseq": "2410002L03Rik; 5830418D04Rik; L1mt; Mrpl1", "protein_names_uniprotkb": "Large ribosomal subunit protein uL1m; 39S ribosomal protein L1, mitochondrial; L1mt; MRP-L1", "protein_names_refseq": "39S ribosomal protein L1, mitochondrial; large ribosomal subunit protein uL1m isoform 1; large ribosomal subunit protein uL1m", "tax_id": 10090, "disease": "", "pathway": " (mmu:94061); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11279069;16452087;21183079;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQP5;Q8K351;Q9CWW4", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99N96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPR4-1", "uniprot_id": [ { "id": "RL17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPR4", "type": "external" } ], "mass": 21397.0, "length": 184, "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "Rpl17", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL22 isoform a", "refseq_ac": [ { "id": "NP_001002239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002239", "type": "external" } ], "gene_names_uniprotkb": "Rpl17", "gene_names_refseq": "Rpl17", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22; 60S ribosomal protein L17", "protein_names_refseq": "60S ribosomal protein L17; large ribosomal subunit protein uL22 isoform a; large ribosomal subunit protein uL22", "tax_id": 10090, "disease": "", "pathway": " (mmu:319195)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22645316;23065385;36517592;37453647;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWZ7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0006941 striated muscle contraction;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CPR4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ40-1", "uniprot_id": [ { "id": "RM49_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ40", "type": "external" } ], "mass": 19133.0, "length": 166, "protein_name": "Large ribosomal subunit protein mL49", "gene_name": "Mrpl49", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL49", "refseq_ac": [ { "id": "NP_080522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080522", "type": "external" } ], "gene_names_uniprotkb": "Mrpl49", "gene_names_refseq": "L49mt; MRP-L49; Mrpl49; Nof1", "protein_names_uniprotkb": "Large ribosomal subunit protein mL49; 39S ribosomal protein L49, mitochondrial; L49mt; MRP-L49", "protein_names_refseq": "39S ribosomal protein L49, mitochondrial; large ribosomal subunit protein mL49; neighbor of fau 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18120); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UC21;Q8C5R0;Q8C7P3", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:0005840 ribosome", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQ40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ71-1", "uniprot_id": [ { "id": "RFA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ71", "type": "external" } ], "mass": 13584.0, "length": 121, "protein_name": "Replication protein A 14 kDa subunit", "gene_name": "Rpa3", "organism": "Mouse", "refseq_name": "replication protein A 14 kDa subunit", "refseq_ac": [ { "id": "NP_080908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080908", "type": "external" } ], "gene_names_uniprotkb": "Rpa3", "gene_names_refseq": "14kDa; C330026P08Rik; Rpa3", "protein_names_uniprotkb": "Replication protein A 14 kDa subunit; RF-A protein 3; RP-A p14; Replication factor A protein 3", "protein_names_refseq": "RF-A protein 3; RP-A p14; replication factor A protein 3; replication protein A 14 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:68240); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174437); (R-MMU-176187); (R-MMU-3371453); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-68962); (R-MMU-69166); (R-MMU-69473)", "pathway_count": 27, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25605945;28315936;34428180", "class_list": "", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER), probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006281 DNA repair;GO:0042127 regulation of cell population proliferation;GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQF0-1", "uniprot_id": [ { "id": "RM11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQF0", "type": "external" } ], "mass": 20680.0, "length": 192, "protein_name": "Large ribosomal subunit protein uL11m", "gene_name": "Mrpl11", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL11m", "refseq_ac": [ { "id": "NP_079829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079829", "type": "external" } ], "gene_names_uniprotkb": "Mrpl11", "gene_names_refseq": "2410001P07Rik; L11mt; Mrpl11", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11m; 39S ribosomal protein L11, mitochondrial; L11mt; MRP-L11", "protein_names_refseq": "39S ribosomal protein L11, mitochondrial; large ribosomal subunit protein uL11m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66419); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11279069;19372376;21750661;31219806;34428180", "class_list": "", "function": "Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~67%., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJX7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQL4-1", "uniprot_id": [ { "id": "RM20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQL4", "type": "external" } ], "mass": 17595.0, "length": 149, "protein_name": "Large ribosomal subunit protein bL20m", "gene_name": "Mrpl20", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL20m precursor", "refseq_ac": [ { "id": "NP_079846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079846", "type": "external" } ], "gene_names_uniprotkb": "Mrpl20", "gene_names_refseq": "2610008D01Rik; 4930425I20Rik; Mrpl20", "protein_names_uniprotkb": "Large ribosomal subunit protein bL20m; 39S ribosomal protein L20, mitochondrial; L20mt; MRP-L20", "protein_names_refseq": "39S ribosomal protein L20, mitochondrial; L20mt; MRP-L20; large ribosomal subunit protein bL20m precursor; large ribosomal subunit protein bL20m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66448); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5L3", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQL5-1", "uniprot_id": [ { "id": "RM18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQL5", "type": "external" } ], "mass": 20677.0, "length": 180, "protein_name": "Large ribosomal subunit protein uL18m", "gene_name": "Mrpl18", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL18m", "refseq_ac": [ { "id": "NP_080586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080586", "type": "external" } ], "gene_names_uniprotkb": "Mrpl18", "gene_names_refseq": "1010001C05Rik; HSPC071; MRP-L18; Mrpl18", "protein_names_uniprotkb": "Large ribosomal subunit protein uL18m; 39S ribosomal protein L18, mitochondrial; L18mt; MRP-L18", "protein_names_refseq": "39S ribosomal protein L18, mitochondrial; L18mt; large ribosomal subunit protein uL18m", "tax_id": 10090, "disease": "", "pathway": " (mmu:67681); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "30779550;34428180;39627609", "class_list": "", "function": "Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6N7", "ec_number_list": [], "go_molecular_function": "GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0035928 rRNA import into mitochondrion;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQP0-1", "uniprot_id": [ { "id": "RM33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQP0", "type": "external" } ], "mass": 7416.0, "length": 65, "protein_name": "Large ribosomal subunit protein bL33m", "gene_name": "Mrpl33", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL33m", "refseq_ac": [ { "id": "NP_080072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080072", "type": "external" } ], "gene_names_uniprotkb": "Mrpl33", "gene_names_refseq": "0610009M10Rik; L33mt; MRP-L33; Mrpl33", "protein_names_uniprotkb": "Large ribosomal subunit protein bL33m; 39S ribosomal protein L33, mitochondrial; L33mt; MRP-L33", "protein_names_refseq": "39S ribosomal protein L33, mitochondrial; large ribosomal subunit protein bL33m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66845); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D860", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQS5-1", "uniprot_id": [ { "id": "RIOK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQS5", "type": "external" } ], "mass": 62490.0, "length": 547, "protein_name": "Serine/threonine-protein kinase RIO2", "gene_name": "Riok2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase RIO2", "refseq_ac": [ { "id": "NP_080210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080210", "type": "external" } ], "gene_names_uniprotkb": "Riok2", "gene_names_refseq": "2010110K24Rik; 2410085M17Rik; Riok2", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO2; 2.7.11.1; RIO kinase 2", "protein_names_refseq": "serine/threonine-protein kinase RIO2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67045); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;25428506;25605945;30084848;34359076;34428180;38564577", "class_list": "", "function": "RIO-kinase 2 is essential for hematopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. May regulate the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, may regulate this function., [UniProtKB, UniProtKB]; Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XF3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0046777 protein autophosphorylation;GO:0030071 regulation of mitotic metaphase/anaphase transition;GO:2000208 positive regulation of ribosomal small subunit export from nucleus;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWS1-1", "uniprot_id": [ { "id": "RN135_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWS1", "type": "external" } ], "mass": 46462.0, "length": 417, "protein_name": "E3 ubiquitin-protein ligase RNF135", "gene_name": "Rnf135", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF135", "refseq_ac": [ { "id": "NP_082295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082295", "type": "external" } ], "gene_names_uniprotkb": "Rnf135", "gene_names_refseq": "0610037N03Rik; 2410006N06Rik; Riplet; Rnf135; U 2-3-0", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF135; 2.3.2.27; RING finger protein 135; RING-type E3 ubiquitin transferase RNF135", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF135; RING-type E3 ubiquitin transferase RNF135", "tax_id": 10090, "disease": "", "pathway": " (mmu:71956)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21147464;23950712;28469175;31006531;31335993;35365564;36210013", "class_list": "", "function": "E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (PubMed:31006531). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (By similarity). It is not involved in the innate immune response against DNA viruses (PubMed:21147464)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; E3 Ubiquitin Ligase Riplet Is Expressed in T Cells and Suppresses T Cell-Mediated Antitumor Immune Responses., [RefSeq, PubMed]; Riplet is essential for regulating RIG-I-mediated innate immune response against RNA virus infection in vivo., [RefSeq, PubMed]; Riplet, and not TRIM25, is required endogenously for the ubiquitination of RIG-I., [RefSeq, PubMed]; Riplet-mediated K63-linked polyubiquitination released RIG-I RD autorepression, which allowed the access of positive factors to the RIG-I protein., [RefSeq, PubMed]; Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBK5;Q8R161;Q9DCH3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0010994 free ubiquitin chain polymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CWS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXP4-1", "uniprot_id": [ { "id": "RHG08_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXP4", "type": "external" } ], "mass": 48972.0, "length": 425, "protein_name": "Rho GTPase-activating protein 8", "gene_name": "Arhgap8", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 8", "refseq_ac": [ { "id": "NP_001158099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158099", "type": "external" } ], "gene_names_uniprotkb": "Arhgap8", "gene_names_refseq": "3110043J09Rik; Arhgap8", "protein_names_uniprotkb": "Rho GTPase-activating protein 8; Rho-type GTPase-activating protein 8", "protein_names_refseq": "rho GTPase-activating protein 8; rho-type GTPase-activating protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:73167); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15225876", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JY7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007264 small GTPase-mediated signal transduction;GO:2001136 negative regulation of endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CXP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0Y8-1", "uniprot_id": [ { "id": "RM52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0Y8", "type": "external" } ], "mass": 13658.0, "length": 121, "protein_name": "Large ribosomal subunit protein mL52", "gene_name": "Mrpl52", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL52 precursor", "refseq_ac": [ { "id": "NP_081127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081127", "type": "external" } ], "gene_names_uniprotkb": "Mrpl52", "gene_names_refseq": "1110047B07Rik; Mrpl52", "protein_names_uniprotkb": "Large ribosomal subunit protein mL52; 39S ribosomal protein L52, mitochondrial; L52mt; MRP-L52", "protein_names_refseq": "39S ribosomal protein L52, mitochondrial; L52mt; MRP-L52; large ribosomal subunit protein mL52 precursor; large ribosomal subunit protein mL52", "tax_id": 10090, "disease": "", "pathway": " (mmu:68836); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAU6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1N9-1", "uniprot_id": [ { "id": "RM21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1N9", "type": "external" } ], "mass": 23366.0, "length": 209, "protein_name": "Large ribosomal subunit protein bL21m", "gene_name": "Mrpl21", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL21m isoform 2", "refseq_ac": [ { "id": "NP_001334349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334349", "type": "external" } ], "gene_names_uniprotkb": "Mrpl21; D9Wsu149", "gene_names_refseq": "L21mt; MRP-L21; Mrpl21", "protein_names_uniprotkb": "Large ribosomal subunit protein bL21m; 39S ribosomal protein L21, mitochondrial; L21mt; MRP-L21", "protein_names_refseq": "39S ribosomal protein L21, mitochondrial; large ribosomal subunit protein bL21m isoform 2; large ribosomal subunit protein bL21m", "tax_id": 10090, "disease": "", "pathway": " (mmu:353242); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSH9;Q9D214", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D1N9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7M8-1", "uniprot_id": [ { "id": "RPB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7M8", "type": "external" } ], "mass": 16311.0, "length": 142, "protein_name": "DNA-directed RNA polymerase II subunit RPB4", "gene_name": "Polr2d", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit RPB4 isoform 1", "refseq_ac": [ { "id": "NP_081278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081278", "type": "external" } ], "gene_names_uniprotkb": "Polr2d", "gene_names_refseq": "2310002G05Rik; 2610028L19Rik; HSRBP4; Polr2d; RBP4", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB4; DNA-directed RNA polymerase II subunit D; RNA polymerase II subunit B4", "protein_names_refseq": "DNA-directed RNA polymerase II subunit D; DNA-directed RNA polymerase II subunit RPB4 isoform 1; DNA-directed RNA polymerase II subunit RPB4; RNA polymerase II subunit B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69241); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 22, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;30084848;30779550;34428180", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWW0;Q78KE6", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D7M8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7S7-1", "uniprot_id": [ { "id": "RL22L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7S7", "type": "external" } ], "mass": 14467.0, "length": 122, "protein_name": "Ribosomal protein eL22-like 1", "gene_name": "Rpl22l1", "organism": "Mouse", "refseq_name": "ribosomal protein eL22-like 1 isoform 2", "refseq_ac": [ { "id": "NP_001334155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334155", "type": "external" } ], "gene_names_uniprotkb": "Rpl22l1", "gene_names_refseq": "3110001N18Rik; Rpl22l1", "protein_names_uniprotkb": "Ribosomal protein eL22-like 1; 60S ribosomal protein L22-like 1; Large ribosomal subunit protein eL22-like 1", "protein_names_refseq": "60S ribosomal protein L22-like 1; large ribosomal subunit protein eL22-like 1; ribosomal protein eL22-like 1 isoform 2; ribosomal protein eL22-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68028); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "15345747;17242355;19144319;21183079;21750661;23990801;28076796;31581233;34428180;35046107", "class_list": "", "function": "Either ribosomal protein can support translation, knockdown of Rpl22l1 impairs growth of cells lacking Rpl22. Mechanistically, Rpl22 regulates Rpl22l1 directly by binding to an internal hairpin structure and repressing its expression, [RefSeq, PubMed]; Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis., [RefSeq, PubMed]; RPL22L1 might be a prognostic marker in colorectal cancer and predict 5-Fluorouracil responsiveness. Publication Status: Online-Only, [RefSeq, PubMed]; Rpl22, and its highly homologous paralog Rpl22-Like1 (Rpl22l1 or Like1) play critical, extraribosomal roles in embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXU8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D7S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D823-1", "uniprot_id": [ { "id": "RL37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D823", "type": "external" } ], "mass": 11078.0, "length": 97, "protein_name": "Large ribosomal subunit protein eL37", "gene_name": "Rpl37", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL37", "refseq_ac": [ { "id": "NP_001258519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258519", "type": "external" } ], "gene_names_uniprotkb": "Rpl37", "gene_names_refseq": "EyeLinc4; Gm13826; Rpl37rt; Rpl37", "protein_names_uniprotkb": "Large ribosomal subunit protein eL37; 60S ribosomal protein L37", "protein_names_refseq": "60S ribosomal protein L37; large ribosomal subunit protein eL37", "tax_id": 10090, "disease": "", "pathway": " (mmu:100502825); (mmu:67281); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 12, "publication_count": 8, "publication_id_list": "22645316;25605945;31219806;34428180;35820727;36288343;36517592;37453647", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWV1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019838 growth factor binding;GO:0019843 rRNA binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:1901798 positive regulation of signal transduction by p53 class mediator;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D823-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8P4-1", "uniprot_id": [ { "id": "RM17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8P4", "type": "external" } ], "mass": 20249.0, "length": 176, "protein_name": "Large ribosomal subunit protein bL17m", "gene_name": "Mrpl17", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL17m precursor", "refseq_ac": [ { "id": "NP_079577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079577", "type": "external" } ], "gene_names_uniprotkb": "Mrpl17", "gene_names_refseq": "MRP-L26; Mrpl17; Rpml26", "protein_names_uniprotkb": "Large ribosomal subunit protein bL17m; 39S ribosomal protein L17, mitochondrial; L17mt; MRP-L17", "protein_names_refseq": "39S ribosomal protein L17, mitochondrial; L17mt; MRP-L17; large ribosomal subunit protein bL17m precursor; large ribosomal subunit protein bL17m; ribosomal protein, mitochondrial, L26", "tax_id": 10090, "disease": "", "pathway": " (mmu:27397); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;22645316;31219806;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VR0", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0007005 mitochondrion organization;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D8P4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET26-1", "uniprot_id": [ { "id": "RN114_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET26", "type": "external" } ], "mass": 25745.0, "length": 229, "protein_name": "E3 ubiquitin-protein ligase RNF114", "gene_name": "Rnf114", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF114 isoform 1", "refseq_ac": [ { "id": "NP_109668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109668", "type": "external" } ], "gene_names_uniprotkb": "Rnf114; Zfp228; Zfp313; Znf228; Znf313", "gene_names_refseq": "1110008J21Rik; Rnf114; Zfp228; Zfp313; Znf228", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF114; 2.3.2.27; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 228; Zinc finger protein 313", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF114 isoform 1; E3 ubiquitin-protein ligase RNF114; RING-type E3 ubiquitin transferase RNF114; zinc finger protein 313", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:81018); (R-MMU-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17394778;21750661;23645206;28073917;28625874;34104941;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Also acts as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis., [UniProtKB, UniProtKB]; Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos., [RefSeq, PubMed]; Our study uncovers that RNF114-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB pathway during MZT, and thus directly link maternal clearance to early embryo development., [RefSeq, PubMed]; Present data suggests that Znf313 gene might play a fundamental role in gene transcription and regulation and relates to spermatogenesis., [RefSeq, PubMed]; These data suggested the potential physiological function of RNF114 in inflammation and host antiviral responses, but demonstrate complexity in the regulation of innate immunity by ubiquitin ligases., [RefSeq, PubMed]; ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFU8;Q8K5A2", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ET26-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI90-1", "uniprot_id": [ { "id": "RNF14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI90", "type": "external" } ], "mass": 54926.0, "length": 485, "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "Rnf14", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF14 isoform a", "refseq_ac": [ { "id": "NP_001158093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093", "type": "external" } ], "gene_names_uniprotkb": "Rnf14; Triad2", "gene_names_refseq": "2310075C09Rik; 2610005D23Rik; D18Ertd188e; D7Bwg0165e; Rnf14; Triad2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF14; 2.3.2.31; RING finger protein 14", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF14 isoform a; E3 ubiquitin-protein ligase RNF14; TRIAD2 type I; androgen receptor-associated protein 54; protein Triad2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56736); (R-MMU-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;24472305;25428506", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (By similarity). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (By similarity). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (By similarity). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (By similarity). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:24472305)., [UniProtKB, UniProtKB, PubMed]; RNF14 influences the expression of both mitochondrial and immune related genes Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPR0;Q9D0L2;Q9D6N2;Q9D6Z8;Q9JI89", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0019787 ubiquitin-like protein transferase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006351 DNA-templated transcription;GO:0006415 translational termination;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JI90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJF3-1", "uniprot_id": [ { "id": "RIOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJF3", "type": "external" } ], "mass": 67557.0, "length": 603, "protein_name": "Ribosomal oxygenase 1", "gene_name": "Riox1", "organism": "Mouse", "refseq_name": "ribosomal oxygenase 1", "refseq_ac": [ { "id": "NP_076122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076122", "type": "external" } ], "gene_names_uniprotkb": "Riox1; MNCb-7109; Mapjd; No66", "gene_names_refseq": "2410016O06Rik; MAPJD; NO66; Riox1", "protein_names_uniprotkb": "Ribosomal oxygenase 1; 1.14.11.27; 1.14.11.79; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66", "protein_names_refseq": "bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; myc associated protein with JmjC domain; nucleolar protein 66; ribosomal oxygenase 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:71952); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14742713;19927124;24115157;25736226;25746793;32764136;35210392", "class_list": "", "function": "Data indicate that mesenchymal overexpression of nucleolar protein 66 (NO66) inhibits skeletal cell proliferation., [RefSeq, PubMed]; Mechanisms Regulating Muscle Protein Synthesis in CKD. Erratum:[J Am Soc Nephrol. 2021 Feb;32(2):521. doi: 10.1681/ASN.2020111609. PMID: 33514643], [RefSeq, PubMed]; NO66 regulates bone formation, at least in part, via regulating the number of bone-forming cells and expression of multiple genes that are critical for these processes, [RefSeq, PubMed]; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:19927124). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (PubMed:19927124). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (PubMed:19927124). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (PubMed:19927124). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (PubMed:35210392). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity). Participates in MYC-induced transcriptional activation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Propose that Osx is a molecular switch for the formation of an active chromatin state during osteoblast differentiation, whereas NO66 helps gene repression through histone demethylation and/or formation of a repressor complex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQV2", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0005506 iron ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042254 ribosome biogenesis;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJF3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKF7-1", "uniprot_id": [ { "id": "RM39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKF7", "type": "external" } ], "mass": 38549.0, "length": 336, "protein_name": "Large ribosomal subunit protein mL39", "gene_name": "Mrpl39", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL39 isoform 1", "refseq_ac": [ { "id": "NP_059100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059100", "type": "external" } ], "gene_names_uniprotkb": "Mrpl39", "gene_names_refseq": "C21orf8; MRP-L5; Mrpl39; ORF22; Rpml5", "protein_names_uniprotkb": "Large ribosomal subunit protein mL39; 39S ribosomal protein L39, mitochondrial; L39mt; MRP-L39", "protein_names_refseq": "39S ribosomal protein L39, mitochondrial; L39mt; MRP-L39; large ribosomal subunit protein mL39 isoform 1; large ribosomal subunit protein mL39; ribosomal protein, mitochondrial, L5", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286)", "pathway": " (mmu:27393); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "25428506;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6X954;Q91YK5;Q9D8U5", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0007005 mitochondrion organization;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JKF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUT0-1", "uniprot_id": [ { "id": "RHAG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUT0", "type": "external" } ], "mass": 47837.0, "length": 438, "protein_name": "Ammonium transporter Rh type A", "gene_name": "Rhag", "organism": "Mouse", "refseq_name": "ammonium transporter Rh type A", "refseq_ac": [ { "id": "NP_035399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035399", "type": "external" } ], "gene_names_uniprotkb": "Rhag; Rh50", "gene_names_refseq": "CD241; Rh50A; Rh50; Rhag", "protein_names_uniprotkb": "Ammonium transporter Rh type A; Erythrocyte membrane glycoprotein Rh50; Rh family type A glycoprotein; Rh type A glycoprotein; Rhesus blood group family type A glycoprotein", "protein_names_refseq": "50 kD glycoprotein; ammonium transporter Rh type A; erythrocyte membrane glycoprotein Rh50; rh family type A glycoprotein; rhesus blood group family type A glycoprotein", "tax_id": 10090, "disease": "Rh deficiency syndrome (Disease Ontology:DOID:0050641); overhydrated hereditary stomatocytosis (Disease Ontology:DOID:0111562); renal tubular acidosis (Disease Ontology:DOID:14219); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (mmu:19743); (R-MMU-1237044); (R-MMU-1247673); (R-MMU-444411)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10495887;16564724;16574458;16581281;19807729;21750661;9705835;9929383", "class_list": "", "function": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane (PubMed:19807729). The transport of NH4(+) is electrogenic and masks the NH3 transport. Also, may act as a CO2 channel. Moreover in erythrocyte, regulates RHD membrane expression and is associated with rhesus blood group antigen expression (By similarity)., [UniProtKB, UniProtKB, PubMed]; Review. Rhag plays a major role in the NH3 conductance of erythrocytes, but probably not in CO2 transport. Review article, [RefSeq, PubMed]; RhAG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhAG-expressing cells. Review article, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP27;Q794G1", "ec_number_list": [], "go_molecular_function": "GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding;GO:0022840 leak channel activity;GO:0015200 methylammonium transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0170014 ankyrin-1 complex", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0055085 transmembrane transport;GO:0015670 carbon dioxide transport;GO:0035378 carbon dioxide transmembrane transport;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QUT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH49-1", "uniprot_id": [ { "id": "SESQ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH49", "type": "external" } ], "mass": 29218.0, "length": 266, "protein_name": "Sesquipedalian-1", "gene_name": "Pheta1", "organism": "Mouse", "refseq_name": "sesquipedalian-1", "refseq_ac": [ { "id": "NP_780683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780683", "type": "external" } ], "gene_names_uniprotkb": "Pheta1; Fam109a", "gene_names_refseq": "A230106M15Rik; Fam109a; IPIP27A; Pheta1; Ses1", "protein_names_uniprotkb": "Sesquipedalian-1; 27 kDa inositol polyphosphate phosphatase interacting protein A; IPIP27A; PH domain-containing endocytic trafficking adaptor 1; Ses1", "protein_names_refseq": "27 kDa inositol polyphosphate phosphatase interacting protein A; family with sequence similarity 109, member A; sesquipedalian-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231717)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BH49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62170-1", "uniprot_id": [ { "id": "SELPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62170", "type": "external" } ], "mass": 41842.0, "length": 397, "protein_name": "P-selectin glycoprotein ligand 1", "gene_name": "Selplg", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Selplg; Selp1; Selpl", "gene_names_refseq": "", "protein_names_uniprotkb": "P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand", "protein_names_refseq": "", "tax_id": 10090, "disease": "carotid artery disease (Disease Ontology:DOID:3407)", "pathway": " (R-MMU-202733)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11104809;12370362;12393631;17442598;19144319;21750661;8639776", "class_list": "", "function": "A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0001931 uropod", "go_biological_process": "GO:0050902 leukocyte adhesive activation;GO:0050900 leukocyte migration;GO:0050901 leukocyte tethering or rolling;GO:1903945 positive regulation of hepatocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62170-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESL0-1", "uniprot_id": [ { "id": "SCO2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESL0", "type": "external" } ], "mass": 56592.0, "length": 520, "protein_name": "Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial", "gene_name": "Oxct2b", "organism": "Mouse", "refseq_name": "succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_862907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_862907", "type": "external" } ], "gene_names_uniprotkb": "Oxct2b", "gene_names_refseq": "Oxct2b; Scot-t2", "protein_names_uniprotkb": "Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; 2.8.3.5; 3-oxoacid CoA-transferase 2B; SCOT-t2; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2", "protein_names_refseq": "succinyl CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial precursor; succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:353371); (R-MMU-77108)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11090426;15028287;21750661", "class_list": "", "function": "Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa., [UniProtKB, UniProtKB, UniProtKB]; Oxct2a and Oxct2b are testicular haploid germ cell-specific genes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJ06", "ec_number_list": [ { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" } ], "go_molecular_function": "GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031514 motile cilium", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0046952 ketone body catabolic process;GO:1902224 ketone body metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ESL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKV5-1", "uniprot_id": [ { "id": "SCAM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKV5", "type": "external" } ], "mass": 25342.0, "length": 230, "protein_name": "Secretory carrier-associated membrane protein 4", "gene_name": "Scamp4", "organism": "Mouse", "refseq_name": "secretory carrier-associated membrane protein 4", "refseq_ac": [ { "id": "NP_062521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062521", "type": "external" } ], "gene_names_uniprotkb": "Scamp4", "gene_names_refseq": "2410022D05Rik; Sc4; Scamp4", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 4; SC4; Secretory carrier membrane protein 4", "protein_names_refseq": "secretory carrier-associated membrane protein 4", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:56214)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11050114;21750661;25605945;31219806;34428180", "class_list": "", "function": "Probably involved in membrane protein trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JKV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGD6-1", "uniprot_id": [ { "id": "S38A9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGD6", "type": "external" } ], "mass": 63392.0, "length": 560, "protein_name": "Neutral amino acid transporter 9", "gene_name": "Slc38a9", "organism": "Mouse", "refseq_name": "neutral amino acid transporter 9", "refseq_ac": [ { "id": "NP_848861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848861", "type": "external" } ], "gene_names_uniprotkb": "Slc38a9", "gene_names_refseq": "4833412L08Rik; 6720411P22Rik; 9130023D20Rik; 9430067K09Rik; A730092C09; Slc38a9", "protein_names_uniprotkb": "Neutral amino acid transporter 9; Solute carrier family 38 member 9", "protein_names_refseq": "neutral amino acid transporter 9; putative sodium-coupled neutral amino acid transporter 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:268706); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "19144319;21750661;28235079;29053970;29187734;31219806;34572527", "class_list": "", "function": "After high-fat diet, Slc38a9 was specifically upregulated in hypothalamus, while overall downregulation was noticed throughout the brain. Publication Status: Online-Only, [RefSeq, PubMed]; Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency., [UniProtKB, UniProtKB]; Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80W70;Q8C5C3", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015485 cholesterol binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006868 glutamine transport;GO:0032008 positive regulation of TOR signaling;GO:0071230 cellular response to amino acid stimulus;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BGD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZI9-1", "uniprot_id": [ { "id": "S2551_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5HZI9", "type": "external" } ], "mass": 33689.0, "length": 298, "protein_name": "Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51", "gene_name": "Slc25a51", "organism": "Mouse", "refseq_name": "mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51", "refseq_ac": [ { "id": "NP_001009949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009949", "type": "external" } ], "gene_names_uniprotkb": "Slc25a51; Mcart1", "gene_names_refseq": "9130208E07Rik; D130005A03Rik; Gm138; Mcart1; Slc25a51", "protein_names_uniprotkb": "Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51; Mitochondrial NAD(+) transporter SLC25A51; Mitochondrial carrier triple repeat protein 1; Solute carrier family 25 member 51", "protein_names_refseq": "mitochondrial NAD(+) transporter SLC25A51; mitochondrial carrier triple repeat 1; mitochondrial carrier triple repeat protein 1; mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51", "tax_id": 10090, "disease": "", "pathway": " (mmu:230125); (R-MMU-196807)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;31219806;32906142;33300544;34428180;35932995;37507081", "class_list": "", "function": "Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SLC25A51 is a mammalian mitochondrial NAD(+) transporter., [RefSeq, PubMed]; The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions. GeneRIF: The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions in the liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U190;Q3UCW5", "ec_number_list": [], "go_molecular_function": "GO:0051724 NAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019646 aerobic electron transport chain;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:1990549 mitochondrial NAD transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5HZI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QD59-1", "uniprot_id": [ { "id": "SEC20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6QD59", "type": "external" } ], "mass": 26175.0, "length": 228, "protein_name": "Vesicle transport protein SEC20", "gene_name": "Bnip1", "organism": "Mouse", "refseq_name": "vesicle transport protein SEC20", "refseq_ac": [ { "id": "NP_742161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742161", "type": "external" } ], "gene_names_uniprotkb": "Bnip1; Sec20l; Sec20", "gene_names_refseq": "2010005M06Rik; 5930429G21Rik; Bnip1; Sec20", "protein_names_uniprotkb": "Vesicle transport protein SEC20", "protein_names_refseq": "BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP1; BCL2/adenovirus E1B interacting protein 1, NIP1; SNARE protein SEC20; vesicle transport protein SEC20", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:224630); (R-MMU-6811434)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28315936;31219806;34428180;37507081", "class_list": "", "function": "As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0V2Q1;Q5M9M2", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0048763 calcium-induced calcium release activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0015031 protein transport;GO:0042594 response to starvation;GO:0006915 apoptotic process;GO:0014823 response to activity;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6QD59-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K021-1", "uniprot_id": [ { "id": "SCAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K021", "type": "external" } ], "mass": 38029.0, "length": 338, "protein_name": "Secretory carrier-associated membrane protein 1", "gene_name": "Scamp1", "organism": "Mouse", "refseq_name": "secretory carrier-associated membrane protein 1 isoform 1", "refseq_ac": [ { "id": "NP_083429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083429", "type": "external" } ], "gene_names_uniprotkb": "Scamp1", "gene_names_refseq": "4930505M11Rik; Scamp1", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 1; Secretory carrier membrane protein 1", "protein_names_refseq": "secretory carrier-associated membrane protein 1 isoform 1; secretory carrier-associated membrane protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:107767); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22517741;30084848;32848054;34428180;40021952;40885482", "class_list": "", "function": "Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0045202 synapse;GO:0030659 cytoplasmic vesicle membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8K021-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0P6-1", "uniprot_id": [ { "id": "SC11A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0P6", "type": "external" } ], "mass": 20626.0, "length": 179, "protein_name": "Signal peptidase complex catalytic subunit SEC11A", "gene_name": "Sec11a", "organism": "Mouse", "refseq_name": "signal peptidase complex catalytic subunit SEC11A isoform 1", "refseq_ac": [ { "id": "NP_064335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064335", "type": "external" } ], "gene_names_uniprotkb": "Sec11a; Sec11l1; Sid2895; Spc18", "gene_names_refseq": "1810012E07Rik; 18kDa; Sec11a; Sec11l1; Sid2895p; Spc18; sid2895", "protein_names_uniprotkb": "Signal peptidase complex catalytic subunit SEC11A; 3.4.21.89; Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18; SPase 18 kDa subunit; Sid 2895", "protein_names_refseq": "SEC11-like protein 1; SPase 18 kDa subunit; Sec11-like 1; endopeptidase SP18; microsomal signal peptidase 18 kDa subunit; sid 2895; signal peptidase complex (18kD); signal peptidase complex catalytic subunit SEC11A isoform 1; signal peptidase complex catalytic subunit SEC11A", "tax_id": 10090, "disease": "", "pathway": " (mmu:56529); (R-MMU-422085); (R-MMU-9768727)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;39627609", "class_list": "", "function": "Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.89", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R0P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YXK1-1", "uniprot_id": [ { "id": "SAMD1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YXK1", "type": "external" } ], "mass": 54533.0, "length": 519, "protein_name": "Sterile alpha motif domain-containing protein 1", "gene_name": "Samd1", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 1", "refseq_ac": [ { "id": "NP_001074884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074884", "type": "external" } ], "gene_names_uniprotkb": "Samd1", "gene_names_refseq": "Samd1", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 1; Atherin; SAM domain-containing protein 1", "protein_names_refseq": "SAM domain-containing protein 1; atherin; sterile alpha motif domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:666704)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19144319;21183079;31219806;33980486;34006929", "class_list": "", "function": "Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486, PubMed:34006929). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:34006929)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0006325 chromatin organization;GO:0090077 foam cell differentiation;GO:0034439 lipoprotein lipid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3YXK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R238-1", "uniprot_id": [ { "id": "SDSL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R238", "type": "external" } ], "mass": 34732.0, "length": 329, "protein_name": "Serine dehydratase-like", "gene_name": "Sdsl", "organism": "Mouse", "refseq_name": "serine dehydratase-like", "refseq_ac": [ { "id": "NP_598663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598663", "type": "external" } ], "gene_names_uniprotkb": "Sdsl; Sds", "gene_names_refseq": "4432411H13Rik; SDH1; SDS-RS1; Sdsl; TDH", "protein_names_uniprotkb": "Serine dehydratase-like; 4.3.1.17; 4.3.1.19; 5.1.1.3; Glutamate racemase; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; SDH; TDH", "protein_names_refseq": "L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; SDH; glutamate racemase; serine dehydratase related sequence 1; serine dehydratase-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:257635); (R-MMU-8849175); (R-MMU-977347)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12080145;15757516;21750661", "class_list": "", "function": "Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively. Also exhibits racemase activity towards L-glutamate and D-glutamate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI05", "ec_number_list": [ { "id": "4.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.17", "type": "external" }, { "id": "4.3.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.19", "type": "external" }, { "id": "5.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.1.3", "type": "external" }, { "id": "4.3.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.18", "type": "external" }, { "id": "5.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0003941 L-serine ammonia-lyase activity;GO:0004794 threonine deaminase activity;GO:0008881 glutamate racemase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006567 L-threonine catabolic process;GO:0006565 L-serine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R238-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8V7-1", "uniprot_id": [ { "id": "SC11C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8V7", "type": "external" } ], "mass": 21660.0, "length": 192, "protein_name": "Signal peptidase complex catalytic subunit SEC11C", "gene_name": "Sec11c", "organism": "Mouse", "refseq_name": "signal peptidase complex catalytic subunit SEC11C", "refseq_ac": [ { "id": "NP_079744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079744", "type": "external" } ], "gene_names_uniprotkb": "Sec11c; Sec11l3; Spc21", "gene_names_refseq": "1810029G24Rik; Sec11c; Sec11l3", "protein_names_uniprotkb": "Signal peptidase complex catalytic subunit SEC11C; 3.4.21.89; Microsomal signal peptidase 21 kDa subunit; SEC11 homolog C; SEC11-like protein 3; SPC21; SPase 21 kDa subunit", "protein_names_refseq": "SEC11-like protein 3; SPC21; SPase 21 kDa subunit; Sec11-like 3; microsomal signal peptidase 21 kDa subunit; signal peptidase complex catalytic subunit SEC11C", "tax_id": 10090, "disease": "", "pathway": " (mmu:66286); (R-MMU-422085); (R-MMU-9768727)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.89", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex;GO:0016020 membrane", "go_biological_process": "GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D8V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62181-1", "uniprot_id": [ { "id": "SEM3C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62181", "type": "external" } ], "mass": 85289.0, "length": 751, "protein_name": "Semaphorin-3C", "gene_name": "Sema3c", "organism": "Mouse", "refseq_name": "semaphorin-3C precursor", "refseq_ac": [ { "id": "NP_038685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038685", "type": "external" } ], "gene_names_uniprotkb": "Sema3c; SemE; Semae", "gene_names_refseq": "1110036B02Rik; SemE; Sema3c; Semae", "protein_names_uniprotkb": "Semaphorin-3C; Sema E; Semaphorin-E", "protein_names_refseq": "sema E; semaphorin E; semaphorin-3C precursor; semaphorin-3C", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:20348)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11688556;15239958;17021275;21750661;37828378;7748561", "class_list": "", "function": "Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9910, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXW7", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0003350 pulmonary myocardium development;GO:0140074 cardiac endothelial to mesenchymal transition;GO:0007507 heart development;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62181-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTM3-1", "uniprot_id": [ { "id": "SEM6C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTM3", "type": "external" } ], "mass": 99538.0, "length": 931, "protein_name": "Semaphorin-6C", "gene_name": "Sema6c", "organism": "Mouse", "refseq_name": "semaphorin-6C isoform 1 precursor", "refseq_ac": [ { "id": "NP_001258953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258953", "type": "external" } ], "gene_names_uniprotkb": "Sema6c; Semay", "gene_names_refseq": "Sema6c; Semay; mKIAA1869", "protein_names_uniprotkb": "Semaphorin-6C; Sema Y; Semaphorin-Y", "protein_names_refseq": "Sema Y; m-Sema Y; semaphorin-6C isoform 1 precursor; semaphorin-6C; semaphorin-Y", "tax_id": 10090, "disease": "", "pathway": " (mmu:20360)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10049528;21750661;30256425", "class_list": "", "function": "May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity)., [UniProtKB]; Sema6c was involved in follicle development, and the suppression of SEMA6C led to cell junction defection by activating the PI3K/AKT pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0007411 axon guidance;GO:0030517 negative regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28705-1", "uniprot_id": [ { "id": "RXRG_MOUSE", "url": "https://www.uniprot.org/uniprot/P28705", "type": "external" } ], "mass": 50893.0, "length": 463, "protein_name": "Retinoic acid receptor RXR-gamma", "gene_name": "Rxrg", "organism": "Mouse", "refseq_name": "retinoic acid receptor RXR-gamma isoform 2", "refseq_ac": [ { "id": "NP_001153203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153203", "type": "external" } ], "gene_names_uniprotkb": "Rxrg; Nr2b3", "gene_names_refseq": "Nr2b3; Rxrg", "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma", "protein_names_refseq": "nuclear receptor subfamily 2 group B member 3; retinoic acid receptor RXR-gamma isoform 2; retinoic acid receptor RXR-gamma", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:20183); (R-MMU-383280); (R-MMU-5362517)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1310259;1312497;21750661;26030625;30059200;8391126", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28705-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61420-1", "uniprot_id": [ { "id": "S35A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61420", "type": "external" } ], "mass": 36453.0, "length": 336, "protein_name": "CMP-sialic acid transporter", "gene_name": "Slc35a1", "organism": "Mouse", "refseq_name": "CMP-sialic acid transporter isoform 3", "refseq_ac": [ { "id": "NP_036025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036025", "type": "external" } ], "gene_names_uniprotkb": "Slc35a1", "gene_names_refseq": "CMP-SA-Tr; CMP-Sia-Tr; CST; Slc35a1", "protein_names_uniprotkb": "CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; CST; Solute carrier family 35 member A1", "protein_names_refseq": "CMP-sialic acid transporter isoform 3; CMP-sialic acid transporter; solute carrier family 35 member A1", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIf (Disease Ontology:DOID:0070258)", "pathway": " (mmu:24060); (R-MMU-4085001); (R-MMU-727802); (R-MMU-9939291)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10085119;15932921;21750661;30084848;30985278;33087464;34015330;34428180;38467191;8755516", "class_list": "glycogene", "function": "Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Detailed visualization of extensive protein-substrate interactions explains the mechanisms governing substrate selectivity. Further structural analysis of mCST's unique lumen-facing partially-occluded conformation, coupled with the characterization of substrate-induced quenching of mCST's intrinsic tryptophan fluorescence, reveals the concerted conformational transitions that occur during substrate transport. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice., [RefSeq, PubMed]; Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:10085119, PubMed:30985278, PubMed:34015330, PubMed:8755516). Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (PubMed:30985278). Also able to exchange CMP-sialic acid for AMP and UMP (By similarity). Also mediates the transport of CDP-ribitol (By similarity) (PubMed:34015330)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AT44", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005456 CMP-N-acetylneuraminate transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0015782 CMP-N-acetylneuraminate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61420-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R127-1", "uniprot_id": [ { "id": "SCPDL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R127", "type": "external" } ], "mass": 47129.0, "length": 429, "protein_name": "Saccharopine dehydrogenase-like oxidoreductase", "gene_name": "Sccpdh", "organism": "Mouse", "refseq_name": "saccharopine dehydrogenase-like oxidoreductase isoform 1", "refseq_ac": [ { "id": "NP_848768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848768", "type": "external" } ], "gene_names_uniprotkb": "Sccpdh", "gene_names_refseq": "C330023F11Rik; Sccpdh", "protein_names_uniprotkb": "Saccharopine dehydrogenase-like oxidoreductase; 1.-.-.-", "protein_names_refseq": "probable saccharopine dehydrogenase; saccharopine dehydrogenase-like oxidoreductase isoform 1; saccharopine dehydrogenase-like oxidoreductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:109232); (R-MMU-114608)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;33300544;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMB9", "ec_number_list": [ { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0030496 midbody", "go_biological_process": "GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R127-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63836-1", "uniprot_id": [ { "id": "SBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63836", "type": "external" } ], "mass": 52610.0, "length": 472, "protein_name": "Selenium-binding protein 2", "gene_name": "Selenbp2", "organism": "Mouse", "refseq_name": "selenium-binding protein 2", "refseq_ac": [ { "id": "NP_062287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062287", "type": "external" } ], "gene_names_uniprotkb": "Selenbp2; Lpsb2", "gene_names_refseq": "AP56; Lpsb2; Selenbp2", "protein_names_uniprotkb": "Selenium-binding protein 2; 56 kDa acetaminophen-binding protein; AP56", "protein_names_refseq": "56 kDa acetaminophen-binding protein; selenium-binding protein 2", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:20342)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15378723;1540179;16532517;21750661;31219806;34105348;36064721;37453647;8453708", "class_list": "", "function": "Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; It was shown that the observed differences in SBP2 abundance correlate with sex differences in transcription of the gene encoding SBP2, selenbp2, as revealed by RT-PCR and restriction digest as well as sequence analysis of the products., [RefSeq, PubMed]; Selenium- and acetaminophen-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1T6", "ec_number_list": [ { "id": "1.8.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.4", "type": "external" } ], "go_molecular_function": "GO:0008430 selenium binding;GO:0018549 methanethiol oxidase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane;GO:0001650 fibrillar center;GO:0005634 nucleus", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q63836-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09126-1", "uniprot_id": [ { "id": "SEM4D_MOUSE", "url": "https://www.uniprot.org/uniprot/O09126", "type": "external" } ], "mass": 95640.0, "length": 861, "protein_name": "Semaphorin-4D", "gene_name": "Sema4d", "organism": "Mouse", "refseq_name": "semaphorin-4D isoform 1 precursor", "refseq_ac": [ { "id": "NP_001268809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268809", "type": "external" } ], "gene_names_uniprotkb": "Sema4d; Semacl2; Semaj", "gene_names_refseq": "CD100; Sema4d; Semacl2; Semaj; Semcl2; coll-4", "protein_names_uniprotkb": "Semaphorin-4D; M-Sema G; Sema J; Semaphorin-C-like 2; Semaphorin-J", "protein_names_refseq": "M-sema G; sema J; semaphorin H; semaphorin-4D isoform 1 precursor; semaphorin-4D; semaphorin-C-like 2; semaphorin-J", "tax_id": 10090, "disease": "", "pathway": " (mmu:20354); (R-MMU-416550); (R-MMU-416572); (R-MMU-416700)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;17554007;19349973;21183079;21750661;23699507;26495903;26740625;27802388;28011936;28935714;29187734;29981480;30899004;31219806;32069316;32152506;33300544;35984892;39334386;8969198", "class_list": "", "function": "Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (PubMed:23699507, PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (PubMed:23699507, PubMed:29981480). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). Promotes the migration of cerebellar granule cells (PubMed:17554007). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (By similarity). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTM9", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0030215 semaphorin receptor binding;GO:0042802 identical protein binding;GO:0038191 neuropilin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0002116 semaphorin receptor complex;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0031344 regulation of cell projection organization;GO:0043931 ossification involved in bone maturation;GO:0061430 bone trabecula morphogenesis;GO:0070486 leukocyte aggregation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "O09126-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35602-1", "uniprot_id": [ { "id": "RX_MOUSE", "url": "https://www.uniprot.org/uniprot/O35602", "type": "external" } ], "mass": 36335.0, "length": 342, "protein_name": "Retinal homeobox protein Rx", "gene_name": "Rax", "organism": "Mouse", "refseq_name": "retinal homeobox protein Rx", "refseq_ac": [ { "id": "NP_038861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038861", "type": "external" } ], "gene_names_uniprotkb": "Rax; Rx", "gene_names_refseq": "7530406A22Rik; E130303K03Rik; Rax; Rx; ey-1; ey1", "protein_names_uniprotkb": "Retinal homeobox protein Rx; Retina and anterior neural fold homeobox protein", "protein_names_refseq": "Rx/rax homeoprotein; eyeless 1; retina and anterior neural fold homeobox protein; retinal homeobox protein Rx", "tax_id": 10090, "disease": "syndromic microphthalmia 16 (Disease Ontology:DOID:0060842)", "pathway": " (mmu:19434)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;9096350;9177348", "class_list": "", "function": "Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08748;Q6GT92", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35602-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88627-1", "uniprot_id": [ { "id": "S28A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88627", "type": "external" } ], "mass": 72916.0, "length": 660, "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "Slc28a2", "organism": "Mouse", "refseq_name": "sodium/nucleoside cotransporter 2", "refseq_ac": [ { "id": "NP_766568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766568", "type": "external" } ], "gene_names_uniprotkb": "Slc28a2; Cnt2", "gene_names_refseq": "2010208B10Rik; B430217P18; Cnt2; SPNT; Slc28a2", "protein_names_uniprotkb": "Sodium/nucleoside cotransporter 2; CNT 2; Concentrative nucleoside transporter 2; Na(+)/nucleoside cotransporter 2; SPNT; Sodium-coupled nucleoside transporter 2; Sodium/purine nucleoside cotransporter; Solute carrier family 28 member 2", "protein_names_refseq": "Na(+)/nucleoside cotransporter 2; concentrative nucleoside transporter 2; purine-selective Na+ nucleoside cotransporter; sodium/nucleoside cotransporter 2; sodium/purine nucleoside cotransporter", "tax_id": 10090, "disease": "", "pathway": " (mmu:269346); (R-MMU-83936); (R-MMU-9748787); (R-MMU-9755088)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10721696;17013559;20421393;29187734;29595077;30084848;30779550;34428180;37159505", "class_list": "", "function": "Data concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes., [RefSeq, PubMed]; It is a purine nucleoside preferring transporter playing a central role in the gastrointestinal absorption of purines in the enterocytes., [RefSeq, PubMed]; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB]; TGF-beta1 transcriptionally activates the CNT2-encoding gene in a JNK-dependent manner., [RefSeq, PubMed]; The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJP1", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity;GO:0005345 purine nucleobase transmembrane transporter activity;GO:0005337 nucleoside transmembrane transporter activity", "go_cellular_component": "GO:0030135 coated vesicle;GO:0005886 plasma membrane;GO:0031526 brush border membrane;GO:0012506 vesicle membrane;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport;GO:0001895 retina homeostasis;GO:0006836 neurotransmitter transport;GO:1901642 nucleoside transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O88627-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31532-1", "uniprot_id": [ { "id": "SAA4_MOUSE", "url": "https://www.uniprot.org/uniprot/P31532", "type": "external" } ], "mass": 15088.0, "length": 130, "protein_name": "Serum amyloid A-4 protein", "gene_name": "Saa4", "organism": "Mouse", "refseq_name": "serum amyloid A-4 protein precursor", "refseq_ac": [ { "id": "NP_035446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035446", "type": "external" } ], "gene_names_uniprotkb": "Saa4; Saa5", "gene_names_refseq": "Saa-4; Saa-5; Saa4", "protein_names_uniprotkb": "Serum amyloid A-4 protein; Amyloid A-5 protein", "protein_names_refseq": "amyloid A-5 protein; serum amyloid A-4 protein precursor; serum amyloid A-4 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20211)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1741755;30084848;34428180;8308037;8661036;9042428", "class_list": "", "function": "Major acute phase reactant., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P31532-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USY0-1", "uniprot_id": [ { "id": "S38AB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USY0", "type": "external" } ], "mass": 49615.0, "length": 453, "protein_name": "Putative sodium-coupled neutral amino acid transporter 11", "gene_name": "Slc38a11", "organism": "Mouse", "refseq_name": "putative sodium-coupled neutral amino acid transporter 11", "refseq_ac": [ { "id": "NP_796048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796048", "type": "external" } ], "gene_names_uniprotkb": "Slc38a11", "gene_names_refseq": "9330158F14Rik; Slc38a11", "protein_names_uniprotkb": "Putative sodium-coupled neutral amino acid transporter 11; Solute carrier family 38 member 11", "protein_names_refseq": "putative sodium-coupled neutral amino acid transporter 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:320106)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative sodium-dependent amino acid/proton antiporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ASI0;A2ASI1", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0003333 amino acid transmembrane transport;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3USY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66PY1-1", "uniprot_id": [ { "id": "SCUB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66PY1", "type": "external" } ], "mass": 108984.0, "length": 993, "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 3", "gene_name": "Scube3", "organism": "Mouse", "refseq_name": "signal peptide, CUB and EGF-like domain-containing protein 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001004366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004366", "type": "external" } ], "gene_names_uniprotkb": "Scube3", "gene_names_refseq": "CEGF3; D030038I21Rik; Scube3", "protein_names_uniprotkb": "Signal peptide, CUB and EGF-like domain-containing protein 3", "protein_names_refseq": "signal peptide, CUB and EGF-like domain-containing protein 3 isoform 1 precursor; signal peptide, CUB and EGF-like domain-containing protein 3", "tax_id": 10090, "disease": "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2 (Disease Ontology:DOID:0112358)", "pathway": " (mmu:268935); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15234972;21750661;23383134;30899004;33308444;37189178", "class_list": "", "function": "Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development (PubMed:33308444). It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (By similarity). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (PubMed:33308444). Binds to TGFBR2 and activates TGFB signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse. Erratum:[PLoS One. 2013;8(9). doi:10.1371/annotation/b65bdf5d-4917-4936-9d9d-f217ab2602cd], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2KF22;Q68FG9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0070700 BMP receptor binding;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007165 signal transduction;GO:0030513 positive regulation of BMP signaling pathway;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q66PY1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZL8-1", "uniprot_id": [ { "id": "SCUB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZL8", "type": "external" } ], "mass": 111606.0, "length": 1018, "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 1", "gene_name": "Scube1", "organism": "Mouse", "refseq_name": "signal peptide, CUB and EGF-like domain-containing protein 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001258401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258401", "type": "external" } ], "gene_names_uniprotkb": "Scube1", "gene_names_refseq": "7330410C13Rik; A630023E24Rik; Scube1", "protein_names_uniprotkb": "Signal peptide, CUB and EGF-like domain-containing protein 1", "protein_names_refseq": "signal peptide, CUB and EGF-like domain-containing protein 1 isoform a precursor; signal peptide, CUB and EGF-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64706); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11087664;18303018;19101956;20042401;21750661;30899004;36005562", "class_list": "", "function": "Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology., [UniProtKB, UniProtKB, UniProtKB]; During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth, suggestina a role for Scube1 during early craniofacial development., [RefSeq, PubMed]; SCUBE1 may be involved in the regulation of tubular cell proliferation and re-epithelialization during the resolution of kidney injury., [RefSeq, PubMed]; Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; These results support the dual roles of SCUBE1 on brain morphogenesis and cell-cell adhesions through its distinct domain function., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9Q4;Q9EQC6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6NZL8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q762D5-1", "uniprot_id": [ { "id": "S35D2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q762D5", "type": "external" } ], "mass": 35896.0, "length": 326, "protein_name": "Nucleotide sugar transporter SLC35D2", "gene_name": "Slc35d2", "organism": "Mouse", "refseq_name": "nucleotide sugar transporter SLC35D2", "refseq_ac": [ { "id": "NP_001001321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001321", "type": "external" } ], "gene_names_uniprotkb": "Slc35d2; Ugtrel8", "gene_names_refseq": "5730408I21Rik; SQV7L; Slc35d2; UGTrel8; hfrc; mUGTrel8", "protein_names_uniprotkb": "Nucleotide sugar transporter SLC35D2; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8", "protein_names_refseq": "UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UDP-galactose transporter-related protein 8; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; nucleotide sugar transporter SLC35D2", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:70484); (R-MMU-2022854); (R-MMU-2022928); (R-MMU-727802)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "20485683;21750661;22872234;25428506;31361958;34428180", "class_list": "glycogene", "function": "Nucleotide sugar antiporter transporting UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the lumen of the Golgi in exchange of UMP. By supplying UDP-N-acetylglucosamine, a donor substrate to heparan sulfate synthases, probably takes part in the synthesis of these glycoconjugates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXR0;Q762D4;Q811G6", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005338 nucleotide-sugar transmembrane transporter activity;GO:0005461 UDP-glucuronate transmembrane transporter activity;GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005463 UDP-N-acetylgalactosamine transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0015780 nucleotide-sugar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q762D5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78IQ7-1", "uniprot_id": [ { "id": "S39A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78IQ7", "type": "external" } ], "mass": 71063.0, "length": 660, "protein_name": "Zinc transporter ZIP4", "gene_name": "Slc39a4", "organism": "Mouse", "refseq_name": "zinc transporter ZIP4 precursor", "refseq_ac": [ { "id": "NP_082340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082340", "type": "external" } ], "gene_names_uniprotkb": "Slc39a4; Zip4", "gene_names_refseq": "1600025H15Rik; AWMS2; Slc39a4; ZIP4", "protein_names_uniprotkb": "Zinc transporter ZIP4; Activated in W/Wv mouse stomach 2; Solute carrier family 39 member 4; ZIP-4; Zrt- and Irt-like protein 4; mAWMS2", "protein_names_refseq": "activated in W/Wv mouse stomach 2; zinc transporter ZIP4 precursor; zinc transporter ZIP4; zrt- and Irt-like protein 4", "tax_id": 10090, "disease": "acrodermatitis enteropathica (Disease Ontology:DOID:0050605)", "pathway": " (mmu:72027); (R-MMU-442380)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12801924;14612438;14709598;17242355;17483098;18020946;18936158;21750661;22737083;25428506;30593504;34428180;34843931", "class_list": "", "function": "Results provide compelling evidence that ZIP4 is a zinc transporter that plays an important role in zinc homeostasis, a process that is defective in acrodermatitis enteropathica in humans, [RefSeq, PubMed]; Selective transporter that mediates the uptake of Zn(2+) (PubMed:12801924, PubMed:14612438, PubMed:14709598). Plays an essential role for dietary zinc uptake from small intestine (PubMed:12801924). The Zn(2+) uniporter activity is regulated by zinc availability (By similarity). Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:12801924)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations., [UniProtKB, UniProtKB]; Slc39a4 in the small intestine predicts zinc absorption and utilization: a comprehensive analysis of zinc transporter expression in response to diets of varied zinc content in young mice., [RefSeq, PubMed]; Zinc deficiency increased mZIP4 protein levels at the plasma membrane, and this was associated with increased zinc uptake., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHL4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0106219 zinc ion sensor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis;GO:0034224 cellular response to zinc ion starvation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q78IQ7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TS8-1", "uniprot_id": [ { "id": "SE1L3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TS8", "type": "external" } ], "mass": 128680.0, "length": 1137, "protein_name": "Protein sel-1 homolog 3", "gene_name": "Sel1l3", "organism": "Mouse", "refseq_name": "protein sel-1 homolog 3", "refseq_ac": [ { "id": "NP_766298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766298", "type": "external" } ], "gene_names_uniprotkb": "Sel1l3; Kiaa0746", "gene_names_refseq": "2310045A20Rik; Sel1l3; mKIAA0746", "protein_names_uniprotkb": "Protein sel-1 homolog 3; Sel-1L3; Suppressor of lin-12-like protein 3", "protein_names_refseq": "protein sel-1 homolog 3; sel-1L3; suppressor of lin-12-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:231238)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;30084848;31219806", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QPJ6;Q148Y5;Q505D2;Q8BMN0;Q8BYY3;Q8R0K7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80TS8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZD3-1", "uniprot_id": [ { "id": "S2611_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZD3", "type": "external" } ], "mass": 64109.0, "length": 593, "protein_name": "Sodium-independent sulfate anion transporter", "gene_name": "Slc26a11", "organism": "Mouse", "refseq_name": "sodium-independent sulfate anion transporter", "refseq_ac": [ { "id": "NP_848858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848858", "type": "external" } ], "gene_names_uniprotkb": "Slc26a11", "gene_names_refseq": "F630021I08Rik; KBAT; Slc26a11", "protein_names_uniprotkb": "Sodium-independent sulfate anion transporter; KBAT; Kidney brain anion transporter; Solute carrier family 26 member 11", "protein_names_refseq": "anion exchanger Slc26a11; kidney brain anion transporter; novel sulfate transporter protein (Slc26a11); sodium-independent sulfate anion transporter", "tax_id": 10090, "disease": "", "pathway": " (mmu:268512); (R-MMU-174362); (R-MMU-427601)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21716257;23733100;27390771;40885482", "class_list": "glycogene", "function": "Slc26a11 is a partner of vacuolar H(+)-ATPase facilitating acid secretion in the collecting duct., [RefSeq, PubMed]; Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport (By similarity). Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC) (By similarity). In the kidney, mediates chloride-bicarbonate exchange, facilitating V-ATPase-mediated acid secretion (PubMed:21716257). May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum (PubMed:23733100, PubMed:27390771)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Study examined at both the cellular and systems physiological level the function of a recently discovered chloride channel, SLC26A11 or kidney brain anion transporter (KBAT) in Purkinje cells; findings support an important role for SLC26A11 in moderating chloride homeostasis and neuronal activity in the cerebellum. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQF3;Q8BTP1;Q8BWL3;Q8CHW8", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005254 chloride channel activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80ZD3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZQ0-1", "uniprot_id": [ { "id": "SACA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZQ0", "type": "external" } ], "mass": 13380.0, "length": 127, "protein_name": "Sperm acrosome membrane-associated protein 4", "gene_name": "Spaca4", "organism": "Mouse", "refseq_name": "sperm acrosome membrane-associated protein 4 precursor", "refseq_ac": [ { "id": "NP_081331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081331", "type": "external" } ], "gene_names_uniprotkb": "Spaca4", "gene_names_refseq": "1700008E09Rik; Samp14; Spaca4", "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 4", "protein_names_refseq": "sperm acrosomal membrane 14; sperm acrosome membrane-associated protein 4 precursor; sperm acrosome membrane-associated protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69363); (R-MMU-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34556579", "class_list": "", "function": "Sperm surface membrane protein that is essential for effective sperm-zona pellucida binding and penetration during fertilization., [UniProtKB, PubMed]; The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAK7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0002079 inner acrosomal membrane;GO:0002081 outer acrosomal membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80ZQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH47-1", "uniprot_id": [ { "id": "SC22A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH47", "type": "external" } ], "mass": 35025.0, "length": 307, "protein_name": "Vesicle-trafficking protein SEC22a", "gene_name": "Sec22a", "organism": "Mouse", "refseq_name": "vesicle-trafficking protein SEC22a isoform 1", "refseq_ac": [ { "id": "NP_598465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598465", "type": "external" } ], "gene_names_uniprotkb": "Sec22a; Sec22l2", "gene_names_refseq": "1810005C06Rik; Sec22a; Sec22l2", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22a; SEC22 vesicle-trafficking protein homolog A; SEC22 vesicle-trafficking protein-like 2", "protein_names_refseq": "SEC22 vesicle trafficking protein homolog A; SEC22 vesicle trafficking protein homologe A; SEC22 vesicle trafficking protein-like 2; SEC22 vesicle trafficking protein-like A; vesicle-trafficking protein SEC22a isoform 1; vesicle-trafficking protein SEC22a", "tax_id": 10090, "disease": "", "pathway": " (mmu:317717); (R-MMU-204005)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in vesicle transport between the ER and the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z54", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BH47-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHH9-1", "uniprot_id": [ { "id": "SEPT8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHH9", "type": "external" } ], "mass": 49812.0, "length": 429, "protein_name": "Septin-8", "gene_name": "Septin8", "organism": "Mouse", "refseq_name": "septin-8 isoform 2", "refseq_ac": [ { "id": "NP_001239261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239261", "type": "external" } ], "gene_names_uniprotkb": "Septin8; Kiaa0202; Sept8", "gene_names_refseq": "Sepl; Sept8; Septin8", "protein_names_uniprotkb": "Septin-8", "protein_names_refseq": "septin-8 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20362)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10704283;12909369;16452087;17242355;19196426;20173027;21750661;33300544;34428180;36288343;38051778;38308620", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB]; Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics., [RefSeq, PubMed]; Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AQY7;Q80YC7;Q9ESF7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005940 septin ring;GO:0030424 axon;GO:0043209 myelin sheath;GO:0015630 microtubule cytoskeleton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0035542 regulation of SNARE complex assembly;GO:0031647 regulation of protein stability;GO:0008104 intracellular protein localization;GO:0033157 regulation of intracellular protein transport;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CHH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R197-1", "uniprot_id": [ { "id": "SAST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R197", "type": "external" } ], "mass": 30250.0, "length": 265, "protein_name": "S-acyl fatty acid synthase thioesterase, medium chain", "gene_name": "Olah", "organism": "Mouse", "refseq_name": "S-acyl fatty acid synthase thioesterase, medium chain", "refseq_ac": [ { "id": "NP_666033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666033", "type": "external" } ], "gene_names_uniprotkb": "Olah; Thedc1", "gene_names_refseq": "E230009B14Rik; Olah; Thedc1", "protein_names_uniprotkb": "S-acyl fatty acid synthase thioesterase, medium chain; 3.1.2.14; Oleoyl-ACP hydrolase; Thioesterase II; Thioesterase domain-containing protein 1", "protein_names_refseq": "S-acyl fatty acid synthase thioesterase, medium chain; thioesterase II; thioesterase domain containing 1; thioesterase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:99035)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWY0", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" } ], "go_molecular_function": "GO:0016297 fatty acyl-[ACP] hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R197-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCL2-1", "uniprot_id": [ { "id": "SCO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCL2", "type": "external" } ], "mass": 28944.0, "length": 255, "protein_name": "Cytochrome c oxidase assembly protein SCO2", "gene_name": "Sco2", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly protein SCO2", "refseq_ac": [ { "id": "NP_001104758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104758", "type": "external" } ], "gene_names_uniprotkb": "Sco2", "gene_names_refseq": "Sco2", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein SCO2", "protein_names_refseq": "SCO cytochrome oxidase deficient homolog 2; cytochrome c oxidase assembly protein SCO2; protein SCO2 homolog, mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); mitochondrial complex IV deficiency nuclear type 4 (Disease Ontology:DOID:0070493); mitochondrial complex IV deficiency nuclear type 2 (Disease Ontology:DOID:0080357); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); neurodegenerative disease (Disease Ontology:DOID:1289); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); liver disease (Disease Ontology:DOID:409); mitochondrial metabolism disease (Disease Ontology:DOID:700); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:100126824); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16728594;19837698;20864674;21750704;23643385;28428045;31219806;35820727", "class_list": "", "function": "Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2); together with SCO1, facilitates the incorporation of copper into the Cu(A) site of MT-CO2/COX2. Could also act as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2., [UniProtKB, UniProtKB]; Data suggest that physical exercise attenuates age-related changes in mitochondrial COX biogenesis and p53 activity targeting SCO2 and mitochondria, and thereby induces antisenescent and protective effects in cardiac muscle., [RefSeq, PubMed]; Findings show that p53 modulates the balance between the utilization of respiratory and glycolytic pathways; identifed Synthesis of Cytochrome c Oxidase 2 (SCO2) as the downstream mediator of this effect, [RefSeq, PubMed]; Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues., [RefSeq, PubMed]; Sco2 deficient mice develop increased adiposity, liver steatosis, and insulin resistance., [RefSeq, PubMed]; To understand the biological role of SCO2, mice harboring both a Sco2 knock-out (KO) allele and a Sco2 knock-in (KI) E129K allele, corresponding to the common E140K mutation in humans, were studied., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0015035 protein-disulfide reductase activity;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030016 myofibril", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006878 intracellular copper ion homeostasis;GO:0014823 response to activity;GO:0055070 copper ion homeostasis;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCL2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHE0-1", "uniprot_id": [ { "id": "SEC63_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHE0", "type": "external" } ], "mass": 87870.0, "length": 760, "protein_name": "Translocation protein SEC63 homolog", "gene_name": "Sec63", "organism": "Mouse", "refseq_name": "translocation protein SEC63 homolog isoform 1", "refseq_ac": [ { "id": "NP_694695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694695", "type": "external" } ], "gene_names_uniprotkb": "Sec63; Dnajc23; Sec63l", "gene_names_refseq": "5730478J10Rik; Sec63", "protein_names_uniprotkb": "Translocation protein SEC63 homolog; DnaJ homolog subfamily C member 23", "protein_names_refseq": "SEC63-like; dnaJ homolog subfamily C member 23; translocation protein SEC63 homolog isoform 1; translocation protein SEC63 homolog", "tax_id": 10090, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic liver disease 2 (Disease Ontology:DOID:0060975); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:140740)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19208265;21685914;22375059;25844898;30059200;31219806;34428180;37453647;39627609", "class_list": "", "function": "Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914)., [UniProtKB, UniProtKB, PubMed, PubMed]; SEC63 function regulates IRE1alpha/XBP1 activation. SEC63 and XBP1 are required for GPS cleavage and maturation of PC1, protecting against polycystic disease., [RefSeq, PubMed]; SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKG1;Q8VEB9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031207 Sec62/Sec63 complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0001889 liver development;GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0071941 nitrogen cycle metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VHE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZN5-1", "uniprot_id": [ { "id": "S35B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZN5", "type": "external" } ], "mass": 47370.0, "length": 431, "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "gene_name": "Slc35b2", "organism": "Mouse", "refseq_name": "adenosine 3'-phospho 5'-phosphosulfate transporter 1", "refseq_ac": [ { "id": "NP_001344034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001344034", "type": "external" } ], "gene_names_uniprotkb": "Slc35b2; J207", "gene_names_refseq": "1110003M08Rik; PAPST1; Slc35b1; Slc35b2", "protein_names_uniprotkb": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Solute carrier family 35 member B2", "protein_names_refseq": "PAPS transporter 1; adenosine 3'-phospho 5'-phosphosulfate transporter 1; solute carrier family 35, member B1", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 26 (Disease Ontology:DOID:0070403)", "pathway": " (mmu:73836); (R-MMU-174362); (R-MMU-727802)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20011239;21750661;34428180", "class_list": "glycogene", "function": "PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2] Publication Status: Online-Only, [RefSeq, PubMed]; Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U221;Q8BTH2", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0055085 transmembrane transport;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport;GO:0006478 peptidyl-tyrosine sulfation;GO:1902558 5'-adenylyl sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91ZN5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA97-1", "uniprot_id": [ { "id": "SEP14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA97", "type": "external" } ], "mass": 49811.0, "length": 430, "protein_name": "Septin-14", "gene_name": "Septin14", "organism": "Mouse", "refseq_name": "septin-14", "refseq_ac": [ { "id": "NP_083102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083102", "type": "external" } ], "gene_names_uniprotkb": "Septin14; Sept14", "gene_names_refseq": "1700016K13Rik; Sept14; Septin14", "protein_names_uniprotkb": "Septin-14", "protein_names_refseq": "septin-14", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:74222)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20181826;21750661;31219806", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (PubMed:20181826). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (By similarity)., [UniProtKB, PubMed, UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; These results suggest that Sept14 is involved in neuronal migration in cerebral cortex via interaction with Sept4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMM2", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0001764 neuron migration;GO:0007286 spermatid development;GO:0008104 intracellular protein localization;GO:1905719 protein localization to perinuclear region of cytoplasm;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DA97-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET37-1", "uniprot_id": [ { "id": "S5A4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET37", "type": "external" } ], "mass": 71872.0, "length": 656, "protein_name": "Solute carrier family 5 member 4A", "gene_name": "Slc5a4a", "organism": "Mouse", "refseq_name": "solute carrier family 5 member 4A", "refseq_ac": [ { "id": "NP_573447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573447", "type": "external" } ], "gene_names_uniprotkb": "Slc5a4a; Sglt3a", "gene_names_refseq": "SGLT3-a; Slc5a4a", "protein_names_uniprotkb": "Solute carrier family 5 member 4A; SGLT3-a", "protein_names_refseq": "Na(+)/glucose cotransporter 3; low affinity sodium-glucose cotransporter; sodium-dependent glucose cotransporter; sodium/glucose cotransporter 3; solute carrier family 5 member 4A; solute carrier family 5 member 4; solute carrier family 5, member alpha 4a", "tax_id": 10090, "disease": "", "pathway": " (mmu:64452); (R-MMU-189200)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11042146;12969150;22301059;25428506;30084848;34755904", "class_list": "", "function": "Activation of SGLT3a in endometrial epithelial cells induces paracrine stromal cell decidualization., [RefSeq, PubMed]; Does not function as sodium/D-glucose symporter (PubMed:22301059). Generates D-glucose-induced depolarization in a pH-dependent manner, with activity in acidic conditions (pH 5) but not neutral conditions (PubMed:22301059)., [UniProtKB, PubMed]; Mouse SGLT3a did not transport sugar., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E836;Q8R479", "ec_number_list": [], "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0022857 transmembrane transporter activity;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:1902600 proton transmembrane transport;GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ET37-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX96-1", "uniprot_id": [ { "id": "SALL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QX96", "type": "external" } ], "mass": 104944.0, "length": 1004, "protein_name": "Sal-like protein 2", "gene_name": "Sall2", "organism": "Mouse", "refseq_name": "sal-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001231845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231845", "type": "external" } ], "gene_names_uniprotkb": "Sall2; Sal2", "gene_names_refseq": "Msal-2; Sal-2; Sall2; mKIAA0360; p150(Sal2)", "protein_names_uniprotkb": "Sal-like protein 2; Sal-2; Spalt-like protein 2; Zinc finger protein Spalt-2; mSal-2", "protein_names_refseq": "sal-like 2; sal-like protein 2 isoform 2; sal-like protein 2; spalt-like protein 2; zinc finger protein Spalt-2", "tax_id": 10090, "disease": "coloboma (Disease Ontology:DOID:12270); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:50524)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10602995;12482961;15345747;16545361;21750661;24412933;30084848;30779550;31219806;34428180;40885482", "class_list": "", "function": "Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure., [UniProtKB, PubMed, UniProtKB, UniProtKB]; We have now generated mice lacking Sall2.Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5U3X1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QX96-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ03-1", "uniprot_id": [ { "id": "S39A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ03", "type": "external" } ], "mass": 34293.0, "length": 324, "protein_name": "Zinc transporter ZIP1", "gene_name": "Slc39a1", "organism": "Mouse", "refseq_name": "zinc transporter ZIP1", "refseq_ac": [ { "id": "NP_038929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038929", "type": "external" } ], "gene_names_uniprotkb": "Slc39a1; Zip1; Zirtl", "gene_names_refseq": "Slc39a1; Zip1; Zirtl", "protein_names_uniprotkb": "Zinc transporter ZIP1; Solute carrier family 39 member 1; ZIP-1; Zinc-iron-regulated transporter-like; Zrt- and Irt-like protein 1; mZIP1", "protein_names_refseq": "ZIP-1; Zrt/Irt-like protein 1; mZIP1; solute carrier family 39 member 1; zinc transporter ZIP1; zrt- and Irt-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:30791); (R-MMU-442380)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10610721;14525987;15054103;25089007;26979775;34428180;37359521", "class_list": "", "function": "Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Mouse Zrt/Irt-like protein 1 (ZIP1) uptake of zinc is affected by divalent metal cations, [RefSeq, PubMed]; Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space., [UniProtKB, PubMed]; Under oxidative stress-loaded conditions, astrocytes exhibit increased zinc clearance activity and this is due, at least in part, to increased ZIP1 expression., [RefSeq, PubMed]; ZIP1 and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis, [RefSeq, PubMed]; ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTD4;Q99K44", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0001701 in utero embryonic development;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZ03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5F6-1", "uniprot_id": [ { "id": "S39AA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5F6", "type": "external" } ], "mass": 94394.0, "length": 833, "protein_name": "Zinc transporter ZIP10", "gene_name": "Slc39a10", "organism": "Mouse", "refseq_name": "zinc transporter ZIP10 precursor", "refseq_ac": [ { "id": "NP_766241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766241", "type": "external" } ], "gene_names_uniprotkb": "Slc39a10; Kiaa1265; Zip10", "gene_names_refseq": "2900042E17Rik; 5430433I10; Slc39a10; Zip10; mKIAA1265", "protein_names_uniprotkb": "Zinc transporter ZIP10; Solute carrier family 39 member 10; ZIP-10; Zrt- and Irt-like protein 10", "protein_names_refseq": "ZIP-10; solute carrier family 39 member 10; zinc transporter ZIP10 precursor; zinc transporter ZIP10; zrt- and Irt-like protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:227059)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17114649;18936201;19144319;19349973;19656770;21738690;21750661;25074919;27274087;28098160;30520657;30899004;31219806;33300544;36409527;37068188", "class_list": "", "function": "The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis., [RefSeq, PubMed]; The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling., [RefSeq, PubMed]; The expression of Slc30a1, Slc39a8, and Slc39a10 in the erythrocytes of zinc deficient and replete mice is reported., [RefSeq, PubMed]; Zinc-influx transporter. When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). SLC39A10-SLC39A6 heterodimers play also an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Plays an important for both mature B-cell maintenance and humoral immune responses (PubMed:25074919). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (PubMed:28098160)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80TG2;Q8BX42;Q8C0L2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0008160 protein tyrosine phosphatase activator activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0030890 positive regulation of B cell proliferation;GO:0001837 epithelial to mesenchymal transition;GO:0006882 intracellular zinc ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q6P5F6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05367-1", "uniprot_id": [ { "id": "SAA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P05367", "type": "external" } ], "mass": 13622.0, "length": 122, "protein_name": "Serum amyloid A-2 protein", "gene_name": "Saa2", "organism": "Mouse", "refseq_name": "serum amyloid A-2 protein preproprotein", "refseq_ac": [ { "id": "NP_035444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035444", "type": "external" } ], "gene_names_uniprotkb": "Saa2", "gene_names_refseq": "Saa-2; Saa1; Saa2", "protein_names_uniprotkb": "Serum amyloid A-2 protein", "protein_names_refseq": "serum amyloid A 1; serum amyloid A-2 protein preproprotein; serum amyloid A-2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20209)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1590757;21750661;3013853;3624868;36817472;37589058;38193628;3857624", "class_list": "", "function": "Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN., [RefSeq, PubMed]; FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-kappaB signaling pathway., [RefSeq, PubMed]; Major acute phase reactant., [UniProtKB, UniProtKB]; Major acute phase reactant. Apolipoprotein of the HDL complex., [UniProtKB, UniProtKB]; Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006953 acute-phase response;GO:0035634 response to stilbenoid", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P05367-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60714-1", "uniprot_id": [ { "id": "S27A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60714", "type": "external" } ], "mass": 71276.0, "length": 646, "protein_name": "Long-chain fatty acid transport protein 1", "gene_name": "Slc27a1", "organism": "Mouse", "refseq_name": "long-chain fatty acid transport protein 1", "refseq_ac": [ { "id": "NP_036107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036107", "type": "external" } ], "gene_names_uniprotkb": "Slc27a1; Fatp1; Fatp", "gene_names_refseq": "FATP1; Fatp; Slc27a1; Vlc27a1", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 1; 6.2.1.-; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; FATP-1; Fatty acid transport protein 1; Fatty acid transport protein; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 1; Very long-chain acyl-CoA synthetase; Vlc27a1", "protein_names_refseq": "arachidonate--CoA ligase; fatty acid transport protein 1; long-chain fatty acid transport protein 1; long-chain-fatty-acid--CoA ligase; very long-chain acyl-CoA synthetase", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); glucose intolerance (Disease Ontology:DOID:10603); familial hyperlipidemia (Disease Ontology:DOID:1168); hyperinsulinism (Disease Ontology:DOID:2018); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:26457); (R-MMU-804914)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10471110;10593920;11470793;11970897;12235169;12533547;12556534;12937175;14991074;15699031;15897321;19527715;21750661;24858472;28178239;31219806;34428180;7954810;9671728;9765271;9786857", "class_list": "", "function": "Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (Probable) (PubMed:10471110, PubMed:11970897, PubMed:12235169, PubMed:15699031, PubMed:19527715, PubMed:24858472, PubMed:28178239, PubMed:7954810, PubMed:9671728, PubMed:9786857). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10593920, PubMed:12235169, PubMed:12937175). May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169). May be involved in regulation of cholesterol metabolism (PubMed:12235169). Probably involved in fatty acid transport across the blood barrier (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990379 lipid transport across blood-brain barrier;GO:0015878 biotin transport;GO:0001676 long-chain fatty acid metabolic process;GO:0009409 response to cold;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q60714-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFU1-1", "uniprot_id": [ { "id": "S39A9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFU1", "type": "external" } ], "mass": 32368.0, "length": 308, "protein_name": "Zinc transporter ZIP9", "gene_name": "Slc39a9", "organism": "Mouse", "refseq_name": "zinc transporter ZIP9", "refseq_ac": [ { "id": "NP_080520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080520", "type": "external" } ], "gene_names_uniprotkb": "Slc39a9; Zip9", "gene_names_refseq": "2010002A02Rik; 2610511I23Rik; 4833420E20Rik; Slc39a9; Zip9", "protein_names_uniprotkb": "Zinc transporter ZIP9; Solute carrier family 39 member 9; ZIP-9; Zrt- and Irt-like protein 9", "protein_names_refseq": "ZIP-9; solute carrier family 39 member 9; zinc transporter ZIP9; zrt- and Irt-like protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:328133)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26208885;34428180;37305050", "class_list": "", "function": "Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice. Publication Status: Online-Only, [RefSeq, PubMed]; ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RY14", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0004930 G protein-coupled receptor activity;GO:0005497 androgen binding;GO:0022883 zinc efflux transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0070830 bicellular tight junction assembly;GO:0006882 intracellular zinc ion homeostasis;GO:1905562 regulation of vascular endothelial cell proliferation;GO:2000654 regulation of cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BFU1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG16-1", "uniprot_id": [ { "id": "S6A15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG16", "type": "external" } ], "mass": 81792.0, "length": 729, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT2", "gene_name": "Slc6a15", "organism": "Mouse", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT2", "refseq_ac": [ { "id": "NP_001239259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239259", "type": "external" } ], "gene_names_uniprotkb": "Slc6a15; B0at2; Ntt73", "gene_names_refseq": "Slc6a15; v7-3", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT2; Sodium- and chloride-dependent neurotransmitter transporter NTT73; Solute carrier family 6 member 15; Transporter v7-3", "protein_names_refseq": "B0AT2 protein; orphan sodium- and chloride-dependent neurotransmitter transporter NTT73; orphan transporter v7-3; sodium-dependent neutral amino acid transporter B(0)AT2; solute carrier family 6 member 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:103098); (R-MMU-352230); (R-MMU-442660)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16185194;17931606;21750661;28576941;33007132", "class_list": "", "function": "Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid (PubMed:16185194). Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity)., [UniProtKB, UniProtKB, PubMed]; Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons., [RefSeq, PubMed]; Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress., [RefSeq, PubMed]; Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests, [RefSeq, PubMed]; The structure and function of B0AT2 are reported., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q333Y0", "ec_number_list": [], "go_molecular_function": "GO:0005298 proline:sodium symporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity;GO:0015657 branched-chain amino acid:sodium symporter activity;GO:0046872 metal ion binding;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BG16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01730-1", "uniprot_id": [ { "id": "RSU1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01730", "type": "external" } ], "mass": 31550.0, "length": 277, "protein_name": "Ras suppressor protein 1", "gene_name": "Rsu1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rsu1; Rsp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras suppressor protein 1; RSP-1; Rsu-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (R-MMU-446388)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1508180;21750661;30084848;31219806;34428180", "class_list": "", "function": "Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005925 focal adhesion", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007265 Ras protein signal transduction;GO:0010811 positive regulation of cell-substrate adhesion;GO:2000179 positive regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q01730-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AVZ9-1", "uniprot_id": [ { "id": "S43A3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AVZ9", "type": "external" } ], "mass": 56034.0, "length": 502, "protein_name": "Equilibrative nucleobase transporter 1", "gene_name": "Slc43a3", "organism": "Mouse", "refseq_name": "equilibrative nucleobase transporter 1 isoform a", "refseq_ac": [ { "id": "NP_067373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373", "type": "external" } ], "gene_names_uniprotkb": "Slc43a3; Eeg1; Enbt1", "gene_names_refseq": "Eeg1; SEEEG-1; Slc43a3", "protein_names_uniprotkb": "Equilibrative nucleobase transporter 1; Embryonic epithelia gene 1 protein; Solute carrier family 43 member 3", "protein_names_refseq": "embryonic epithelia gene 1 protein; embryonic epithelial gene 1; equilibrative nucleobase transporter 1 isoform a; equilibrative nucleobase transporter 1; selectively expressed in embryonic epithelia protein-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58207)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11704567;21750661;25428506;26455426;30084848;32217606;34428180;39361655", "class_list": "", "function": "Functional comparison of human and murine equilibrative nucleobase transporter 1. Publication Status: Online-Only, [RefSeq, PubMed]; SLC43A3 is an equilibrative nucleobase transporter involved in purine salvage in mammals. Erratum:[Sci Rep. 2016 Mar 04;6:22175. doi: 10.1038/srep22175. PMID: 26940463] Publication Status: Online-Only, [RefSeq, PubMed]; Slc43a3 is a regulator of free fatty acid flux., [RefSeq, PubMed]; Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (By similarity). May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake (PubMed:32217606)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6PX00;Q5FW65;Q8C345;Q9JLF3", "ec_number_list": [], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0015207 adenine transmembrane transporter activity;GO:0015208 guanine transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035344 hypoxanthine transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2AVZ9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YVE8-1", "uniprot_id": [ { "id": "S35G2_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YVE8", "type": "external" } ], "mass": 46395.0, "length": 412, "protein_name": "Solute carrier family 35 member G2", "gene_name": "Slc35g2", "organism": "Mouse", "refseq_name": "solute carrier family 35 member G2", "refseq_ac": [ { "id": "NP_001094953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094953", "type": "external" } ], "gene_names_uniprotkb": "Slc35g2; Tmem22", "gene_names_refseq": "Gm519; Slc35g2; Tmem22", "protein_names_uniprotkb": "Solute carrier family 35 member G2; Transmembrane protein 22", "protein_names_refseq": "solute carrier family 35 member G2; transmembrane protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:245020)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YVE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58059-1", "uniprot_id": [ { "id": "RT21_MOUSE", "url": "https://www.uniprot.org/uniprot/P58059", "type": "external" } ], "mass": 10561.0, "length": 87, "protein_name": "Small ribosomal subunit protein bS21m", "gene_name": "Mrps21", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein bS21m", "refseq_ac": [ { "id": "NP_510964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_510964", "type": "external" } ], "gene_names_uniprotkb": "Mrps21; Rpms21", "gene_names_refseq": "1810031B19Rik; Mrps21; S21mt", "protein_names_uniprotkb": "Small ribosomal subunit protein bS21m; 28S ribosomal protein S21, mitochondrial; MRP-S21; S21mt", "protein_names_refseq": "28S ribosomal protein S21, mitochondrial; small ribosomal subunit protein bS21m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66292); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11402041;21750661;28315936", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58059-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25444-1", "uniprot_id": [ { "id": "RS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P25444", "type": "external" } ], "mass": 31231.0, "length": 293, "protein_name": "Small ribosomal subunit protein uS5", "gene_name": "Rps2", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS5", "refseq_ac": [ { "id": "NP_032529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032529", "type": "external" } ], "gene_names_uniprotkb": "Rps2; Llrep3; Rps4", "gene_names_refseq": "Llrep3; Rps2; S4", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5; 40S ribosomal protein S2; 40S ribosomal protein S4; Protein LLRep3", "protein_names_refseq": "40S ribosomal protein S2; 40S ribosomal protein S4; protein LLRep3; repeat family 3; small ribosomal subunit protein uS5", "tax_id": 10090, "disease": "", "pathway": " (mmu:16898); (R-MMU-156827); (R-MMU-1799339); (R-MMU-3214858); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-8876725); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 15, "publication_count": 24, "publication_id_list": "17242355;21183079;21750661;25428506;25605945;31616917;32152506;32848054;33300544;3405219;34428180;35820727;35822049;35984892;36084651;36210013;36288343;36517592;36852467;37453647;37507081;39627609;39927985;40885482", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:0017134 fibroblast growth factor binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0006412 translation;GO:0051443 positive regulation of ubiquitin-protein transferase activity;GO:0071353 cellular response to interleukin-4;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P25444-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811P0-1", "uniprot_id": [ { "id": "S36A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811P0", "type": "external" } ], "mass": 53068.0, "length": 477, "protein_name": "Proton-coupled amino acid transporter 3", "gene_name": "Slc36a3", "organism": "Mouse", "refseq_name": "proton-coupled amino acid transporter 3 isoform 1", "refseq_ac": [ { "id": "NP_758462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758462", "type": "external" } ], "gene_names_uniprotkb": "Slc36a3; Pat3; Tramd2", "gene_names_refseq": "PAT3; Slc36a3; TRAMD2; tramdorin2", "protein_names_uniprotkb": "Proton-coupled amino acid transporter 3; Proton/amino acid transporter 3; Solute carrier family 36 member 3; Tramdorin-2", "protein_names_refseq": "proton-coupled amino acid transporter 3 isoform 1; proton-coupled amino acid transporter 3; proton/amino acid transporter 3; solute carrier family 36 member 3; tramdorin 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:215332)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12809675;15058382;21750661", "class_list": "", "function": "PAT3 was isolated and identified, but its function is not yet known., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH37", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0005280 amino acid:proton symporter activity", "go_cellular_component": "GO:0005774 vacuolar membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0035524 proline transmembrane transport;GO:0015808 L-alanine transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811P0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35680-1", "uniprot_id": [ { "id": "RT12_MOUSE", "url": "https://www.uniprot.org/uniprot/O35680", "type": "external" } ], "mass": 15437.0, "length": 139, "protein_name": "Small ribosomal subunit protein uS12m", "gene_name": "Mrps12", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS12m isoform a precursor", "refseq_ac": [ { "id": "NP_036015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036015", "type": "external" } ], "gene_names_uniprotkb": "Mrps12; Rpms12", "gene_names_refseq": "Mrps12; Rpms12; rps12", "protein_names_uniprotkb": "Small ribosomal subunit protein uS12m; 28S ribosomal protein S12, mitochondrial; MRP-S12; MT-RPS12; S12mt", "protein_names_refseq": "28S ribosomal protein S12, mitochondrial; MRP-S12; MT-RPS12; S12mt; mitoribosomal protein s12; ribosomal protein, mitochondrial, S12; small ribosomal subunit protein uS12m isoform a precursor; small ribosomal subunit protein uS12m", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:24030); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17179180;19439209;21750661;9434165", "class_list": "", "function": "Identification of an array of 4 CCAAT box elements required for efficient transcription of the Mrps12 gene., [RefSeq, PubMed]; NF-Y type CCAAT boxes are found preferentially in bidirectional Mrps12/Sarsm promoters, but many such promoters lack them and must be regulated in another way., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZK0-1", "uniprot_id": [ { "id": "RT10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZK0", "type": "external" } ], "mass": 18698.0, "length": 160, "protein_name": "Small ribosomal subunit protein uS10m", "gene_name": "Mrps10", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrps10", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10m; 28S ribosomal protein S10, mitochondrial; MRP-S10; S10mt", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:64657); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9837999); (R-MMU-9937383)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9W5", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSG5-1", "uniprot_id": [ { "id": "RSLAB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSG5", "type": "external" } ], "mass": 23229.0, "length": 203, "protein_name": "Ras-like protein family member 10B", "gene_name": "Rasl10b", "organism": "Mouse", "refseq_name": "ras-like protein family member 10B isoform 1", "refseq_ac": [ { "id": "NP_001013404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013404", "type": "external" } ], "gene_names_uniprotkb": "Rasl10b", "gene_names_refseq": "B230331P10Rik; Gm729; Rasl10b; VTS58635", "protein_names_uniprotkb": "Ras-like protein family member 10B; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 10B isoform 1; ras-like protein family member 10B", "tax_id": 10090, "disease": "", "pathway": " (mmu:276952)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17984325;21750661", "class_list": "", "function": "May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide;GO:0090277 positive regulation of peptide hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SSG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05366-1", "uniprot_id": [ { "id": "SAA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P05366", "type": "external" } ], "mass": 13770.0, "length": 122, "protein_name": "Serum amyloid A-1 protein", "gene_name": "Saa1", "organism": "Mouse", "refseq_name": "serum amyloid A-1 protein precursor", "refseq_ac": [ { "id": "NP_033143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033143", "type": "external" } ], "gene_names_uniprotkb": "Saa1", "gene_names_refseq": "Saa-1; Saa1; Saa2", "protein_names_uniprotkb": "Serum amyloid A-1 protein", "protein_names_refseq": "serum amyloid A 2; serum amyloid A-1 protein precursor; serum amyloid A-1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20208)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "3013853;36817472;37022639;37574124;3857624;9518179", "class_list": "", "function": "Major acute phase protein., [UniProtKB, PubMed]; SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-kappaB/p38/JNK and TGFbeta/Smad pathways., [RefSeq, PubMed]; SAA1 exacerbates pancreatic beta-cell dysfunction through activation of NF-kappaB signaling in high-fat diet-induced type 2 diabetes mice., [RefSeq, PubMed]; Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006953 acute-phase response;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P05366-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28704-1", "uniprot_id": [ { "id": "RXRB_MOUSE", "url": "https://www.uniprot.org/uniprot/P28704", "type": "external" } ], "mass": 55866.0, "length": 520, "protein_name": "Retinoic acid receptor RXR-beta", "gene_name": "Rxrb", "organism": "Mouse", "refseq_name": "retinoic acid receptor RXR-beta isoform 4", "refseq_ac": [ { "id": "NP_001192145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192145", "type": "external" } ], "gene_names_uniprotkb": "Rxrb; Nr2b2", "gene_names_refseq": "H-2RIIBP; Nr2b2; RCoR-1; Rub; Rxrb", "protein_names_uniprotkb": "Retinoic acid receptor RXR-beta; MHC class I regulatory element-binding protein H-2RIIBP; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta", "protein_names_refseq": "MHC class I regulatory element-binding protein H-2RIIBP; nuclear receptor subfamily 2 group B member 2; putative retinoid X receptor beta; retinoic acid receptor RXR-beta isoform 4; retinoic acid receptor RXR-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:20182); (R-MMU-383280); (R-MMU-5362517); (R-MMU-9029569); (R-MMU-9623433)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "1310259;1312497;20139090;2554307;30059200;31219806;33872571;34428180;8194750", "class_list": "", "function": "Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1alpha-dependent mitochondrial homeostasis in endothelial cells., [RefSeq, PubMed]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P33243", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28704-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58064-1", "uniprot_id": [ { "id": "RT06_MOUSE", "url": "https://www.uniprot.org/uniprot/P58064", "type": "external" } ], "mass": 14309.0, "length": 125, "protein_name": "Small ribosomal subunit protein bS6m", "gene_name": "Mrps6", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein bS6m", "refseq_ac": [ { "id": "NP_536704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536704", "type": "external" } ], "gene_names_uniprotkb": "Mrps6; Rpms6", "gene_names_refseq": "Mrps6", "protein_names_uniprotkb": "Small ribosomal subunit protein bS6m; 28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt", "protein_names_refseq": "28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt; small ribosomal subunit protein bS6m", "tax_id": 10090, "disease": "", "pathway": " (mmu:121022); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11402041;12036297;18299400;20173027;20484733;22872234;25428506;30084848;30779550;33649389;34428180;35820727;37758822;37828378", "class_list": "", "function": "MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P58064-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62082-1", "uniprot_id": [ { "id": "RS7_MOUSE", "url": "https://www.uniprot.org/uniprot/P62082", "type": "external" } ], "mass": 22127.0, "length": 194, "protein_name": "Small ribosomal subunit protein eS7", "gene_name": "Rps7", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS7", "refseq_ac": [ { "id": "NP_035430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035430", "type": "external" } ], "gene_names_uniprotkb": "Rps7", "gene_names_refseq": "Mtu; Rps7A; Rps7; S7", "protein_names_uniprotkb": "Small ribosomal subunit protein eS7; 40S ribosomal protein S7", "protein_names_refseq": "40S ribosomal protein S7; small ribosomal subunit protein eS7", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 8 (Disease Ontology:DOID:0111881)", "pathway": " (mmu:20115); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 22, "publication_id_list": "18250455;20173027;25428506;25428507;25605945;30084848;31219806;32152506;33300544;33649389;33725478;34428180;35820727;35984892;36288343;36517592;37453647;37507081;39627609;39927985;7522249;9801797", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for rRNA maturation (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23821;P24818", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0048027 mRNA 5'-UTR binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0050821 protein stabilization;GO:0001843 neural tube closure;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P62082-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62307-1", "uniprot_id": [ { "id": "RUXF_MOUSE", "url": "https://www.uniprot.org/uniprot/P62307", "type": "external" } ], "mass": 9725.0, "length": 86, "protein_name": "Small nuclear ribonucleoprotein F", "gene_name": "Snrpf", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein F", "refseq_ac": [ { "id": "NP_081522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081522", "type": "external" } ], "gene_names_uniprotkb": "Snrpf", "gene_names_refseq": "2010013O18Rik; SMF; Snrpf; sm-F; snRNP-F", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein F; Sm protein F; Sm-F; SmF; snRNP-F", "protein_names_refseq": "sm protein F; small nuclear ribonucleoprotein F", "tax_id": 10090, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:69878); (R-MMU-111367); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-73856); (R-MMU-77588); (R-MMU-9770562)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q15356", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0034709 methylosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62307-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62309-1", "uniprot_id": [ { "id": "RUXG_MOUSE", "url": "https://www.uniprot.org/uniprot/P62309", "type": "external" } ], "mass": 8496.0, "length": 76, "protein_name": "Small nuclear ribonucleoprotein G", "gene_name": "Snrpg", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein G", "refseq_ac": [ { "id": "NP_080782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080782", "type": "external" } ], "gene_names_uniprotkb": "Snrpg", "gene_names_refseq": "2810024K17Rik; SMG; Snrpg; sm-G; snRNP-G", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein G; Sm protein G; Sm-G; SmG; snRNP-G", "protein_names_refseq": "sm protein G; small nuclear ribonucleoprotein G", "tax_id": 10090, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:68011); (R-MMU-111367); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-73856); (R-MMU-77588); (R-MMU-9770562)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. IAs a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q15357;Q52KC7", "ec_number_list": [], "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62309-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63163-1", "uniprot_id": [ { "id": "RSMN_MOUSE", "url": "https://www.uniprot.org/uniprot/P63163", "type": "external" } ], "mass": 24614.0, "length": 240, "protein_name": "Small nuclear ribonucleoprotein-associated protein N", "gene_name": "Snrpn", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein-associated protein N", "refseq_ac": [ { "id": "NP_001076430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076430", "type": "external" } ], "gene_names_uniprotkb": "Snrpn; Smn", "gene_names_refseq": "2410045I01Rik; HCERN3; Peg4; SMN; Snrpn; sm-D; snRNP-N", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein N; Sm protein D; Sm protein N; Sm-D; Sm-N; SmN; Tissue-specific-splicing protein; snRNP-N", "protein_names_refseq": "sm protein D; sm protein N; small nuclear ribonucleoprotein-associated protein N; tissue-specific-splicing protein", "tax_id": 10090, "disease": "Prader-Willi syndrome (Disease Ontology:DOID:11983); Angelman syndrome (Disease Ontology:DOID:1932); tauopathy (Disease Ontology:DOID:680)", "pathway": " (mmu:20646); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10318933;1754402;24129315;34428180;35984892;8510173;9294199", "class_list": "", "function": "May be involved in tissue-specific alternative RNA processing events., [UniProtKB]; Snrpn gene is imprinted, with monoallelic expression from the paternal allele in brain and heart., [RefSeq, PubMed]; This locus represents a paternally-expressed imprinted gene that encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. Genomic and genetic changes in this region result in growth defects and lethality; the corresponding region in human is the critical region for Prader-Willi Syndrome. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants may be bicistronic and also encode the SNRPN upstream reading frame protein (Snurf) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (Snhg14) may originate from the promoters at this locus and incorporate exons shared with this gene. [provided by RefSeq, Mar 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14648;P17135", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0070990 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63163-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGM9-1", "uniprot_id": [ { "id": "RTEL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VGM9", "type": "external" } ], "mass": 133767.0, "length": 1203, "protein_name": "Regulator of telomere elongation helicase 1", "gene_name": "Rtel1", "organism": "Mouse", "refseq_name": "regulator of telomere elongation helicase 1 isoform 1", "refseq_ac": [ { "id": "NP_001001882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001882", "type": "external" } ], "gene_names_uniprotkb": "Rtel1; Kiaa1088; Rtel", "gene_names_refseq": "Rtel1; Rtel", "protein_names_uniprotkb": "Regulator of telomere elongation helicase 1; 5.6.2.-", "protein_names_refseq": "DEAH helicase; regulator of telomere elongation helicase 1 isoform 1; regulator of telomere length", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); autosomal recessive dyskeratosis congenita 5 (Disease Ontology:DOID:0070022); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); childhood astrocytic tumor (Disease Ontology:DOID:3079); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); mixed glioma (Disease Ontology:DOID:5076)", "pathway": " (mmu:269400); (R-MMU-171319); (R-MMU-174430)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15210109;18064678;21750661;22579284;22593209;24115439;33357438;38420994;9671732", "class_list": "", "function": "A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere (PubMed:22579284)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed]; Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and Inflammation., [RefSeq, PubMed]; RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AU09;A2AU10;A2AU11;A2AU12;A2AU13;A2AU14;Q3UM40;Q5F0J8;Q69ZS1;Q6H1L0;Q6H1L1;Q6H1L2;Q6H1L3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0043247 telomere maintenance in response to DNA damage;GO:0090657 telomeric loop disassembly;GO:1904430 negative regulation of t-circle formation;GO:1904506 negative regulation of telomere maintenance in response to DNA damage;GO:1904535 positive regulation of telomeric loop disassembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q0VGM9-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1J0-1", "uniprot_id": [ { "id": "S38A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1J0", "type": "external" } ], "mass": 52617.0, "length": 479, "protein_name": "Sodium-coupled neutral amino acid transporter 5", "gene_name": "Slc38a5", "organism": "Mouse", "refseq_name": "sodium-coupled neutral amino acid transporter 5", "refseq_ac": [ { "id": "NP_766067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766067", "type": "external" } ], "gene_names_uniprotkb": "Slc38a5; Jm24; Sn2; Snat5", "gene_names_refseq": "E330031E14; JM24; SN2; Slc38a5", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 5; Solute carrier family 38 member 5; System N transporter 2", "protein_names_refseq": "sodium-coupled neutral amino acid transporter 5; system N transporter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:209837); (R-MMU-352230)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16249471;17032746;18689705;21750661;27802388;34428180;37803043;37812701", "class_list": "", "function": "Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers., [RefSeq, PubMed]; Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction., [RefSeq, PubMed]; Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:15489334, PubMed:16249471). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (PubMed:15489334, PubMed:16249471). The transport activity is pH sensitive, Li(+) tolerant, bidirectional and associated with large uncoupled fluxes of protons (By similarity). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ39;Q8BJZ6;Q8BW30", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0032329 serine transport;GO:1903713 asparagine transmembrane transport;GO:1904557 L-alanine transmembrane transport;GO:0015825 L-serine transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U1J0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EBI0-1", "uniprot_id": [ { "id": "S2610_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5EBI0", "type": "external" } ], "mass": 73200.0, "length": 676, "protein_name": "Solute carrier family 26 member 10", "gene_name": "Slc26a10", "organism": "Mouse", "refseq_name": "solute carrier family 26 member 10", "refseq_ac": [ { "id": "NP_808283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808283", "type": "external" } ], "gene_names_uniprotkb": "Slc26a10", "gene_names_refseq": "D630010I07; Slc26a10", "protein_names_uniprotkb": "Solute carrier family 26 member 10", "protein_names_refseq": "solute carrier family 26 member 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:216441)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34203471", "class_list": "glycogene", "function": "Chloride/bicarbonate exchanger., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1Y7VKB5", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015106 bicarbonate transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5EBI0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61733-1", "uniprot_id": [ { "id": "RT31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61733", "type": "external" } ], "mass": 43881.0, "length": 384, "protein_name": "Small ribosomal subunit protein mS31", "gene_name": "Mrps31", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS31 precursor", "refseq_ac": [ { "id": "NP_065585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065585", "type": "external" } ], "gene_names_uniprotkb": "Mrps31; Imogn38", "gene_names_refseq": "1500002D03Rik; Imogen38; Imogen44; Mrps31", "protein_names_uniprotkb": "Small ribosomal subunit protein mS31; 28S ribosomal protein S31, mitochondrial; Imogen 38; MRP-S31; S31mt", "protein_names_refseq": "28S ribosomal protein S31, mitochondrial; MRP-S31; S31mt; imogen 38; islet mitochondrial antigen, 38 kD; small ribosomal subunit protein mS31 precursor; small ribosomal subunit protein mS31", "tax_id": 10090, "disease": "", "pathway": " (mmu:57312); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "35820727;8567980;9294207", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSP5;Q8VEH4;Q9D045", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61733-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U22-1", "uniprot_id": [ { "id": "RUSC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U22", "type": "external" } ], "mass": 161139.0, "length": 1514, "protein_name": "AP-4 complex accessory subunit RUSC2", "gene_name": "Rusc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rusc2; Kiaa0375", "gene_names_refseq": "", "protein_names_uniprotkb": "AP-4 complex accessory subunit RUSC2; Interacting protein of Rab1; Iporin; RUN and SH3 domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 61 (Disease Ontology:DOID:0080239)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1D6", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80U22-1", "record_type": "protein", "filter_code": "0000000.1000110.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZS3-1", "uniprot_id": [ { "id": "RT26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZS3", "type": "external" } ], "mass": 23444.0, "length": 200, "protein_name": "Small ribosomal subunit protein mS26", "gene_name": "Mrps26", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS26 precursor", "refseq_ac": [ { "id": "NP_997090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997090", "type": "external" } ], "gene_names_uniprotkb": "Mrps26", "gene_names_refseq": "GI008; MRP-S13; MRP-S26; Mrps26; Rpms13", "protein_names_uniprotkb": "Small ribosomal subunit protein mS26; 28S ribosomal protein S26, mitochondrial; MRP-S26; S26mt", "protein_names_refseq": "28S ribosomal protein S26, mitochondrial; S26mt; small ribosomal subunit protein mS26 precursor; small ribosomal subunit protein mS26", "tax_id": 10090, "disease": "", "pathway": " (mmu:99045); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "23576753;31219806;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFU0-1", "uniprot_id": [ { "id": "RSPO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFU0", "type": "external" } ], "mass": 28276.0, "length": 243, "protein_name": "R-spondin-2", "gene_name": "Rspo2", "organism": "Mouse", "refseq_name": "R-spondin-2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_766403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766403", "type": "external" } ], "gene_names_uniprotkb": "Rspo2", "gene_names_refseq": "2610028F08Rik; D430027K22; Rspo2; ftls", "protein_names_uniprotkb": "R-spondin-2; Cristin-2; Cysteine-rich and single thrombospondin domain-containing protein 2; Roof plate-specific spondin-2; mCristin-2", "protein_names_refseq": "R-spondin 2 homolog; R-spondin-2 isoform 2 precursor; cristin-2; cysteine-rich and single thrombospondin domain-containing protein 2; mCristin-2; roof plate-specific spondin-2", "tax_id": 10090, "disease": "tetraamelia syndrome 2 (Disease Ontology:DOID:0112193)", "pathway": " (mmu:239405); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15469841;16543246;21693646;37946278;38758792", "class_list": "", "function": "Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity)., [UniProtKB, PubMed, UniProtKB]; KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3., [RefSeq, PubMed]; Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/beta-catenin pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPX3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0042489 negative regulation of odontogenesis of dentin-containing tooth;GO:0060535 trachea cartilage morphogenesis;GO:0035115 embryonic forelimb morphogenesis;GO:0016055 Wnt signaling pathway;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BFU0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRF7-1", "uniprot_id": [ { "id": "SCFD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRF7", "type": "external" } ], "mass": 72323.0, "length": 639, "protein_name": "Sec1 family domain-containing protein 1", "gene_name": "Scfd1", "organism": "Mouse", "refseq_name": "sec1 family domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001293107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293107", "type": "external" } ], "gene_names_uniprotkb": "Scfd1; Stxbp1l2", "gene_names_refseq": "3110021P21Rik; RA410; STXBP1L2; Scfd1", "protein_names_uniprotkb": "Sec1 family domain-containing protein 1; Syntaxin-binding protein 1-like 2", "protein_names_refseq": "sec1 family domain-containing protein 1 isoform 2; sec1 family domain-containing protein 1; syntaxin-binding protein 1-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76983); (R-MMU-204005); (R-MMU-8980692)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;25428506;31219806;32152506;34428180", "class_list": "", "function": "Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRZ2;Q8K179;Q9CXR8", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005798 Golgi-associated vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0051223 regulation of protein transport;GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BRF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW66-1", "uniprot_id": [ { "id": "S2548_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW66", "type": "external" } ], "mass": 33387.0, "length": 306, "protein_name": "Solute carrier family 25 member 48", "gene_name": "Slc25a48", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 48", "refseq_ac": [ { "id": "NP_808477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808477", "type": "external" } ], "gene_names_uniprotkb": "Slc25a48", "gene_names_refseq": "E230025K15; Slc25a48", "protein_names_uniprotkb": "Solute carrier family 25 member 48", "protein_names_refseq": "putative mitochondrial carrier protein FLJ44862 homolog; solute carrier family 25 member 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:328258)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;39047301;39111307", "class_list": "", "function": "Mitochondrial transporter that mediates choline import across the inner mitochondrial membrane, thereby regulating mitochondrial choline levels and downstream metabolism, including betaine and purine nucleotide synthesis. Plays a key role in mitochondrial respiration, brown fat thermogenesis, and the maintenance of mitochondrial membrane integrity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNJ4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BW66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C850-1", "uniprot_id": [ { "id": "SCAR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C850", "type": "external" } ], "mass": 65471.0, "length": 606, "protein_name": "Scavenger receptor class A member 3", "gene_name": "Scara3", "organism": "Mouse", "refseq_name": "scavenger receptor class A member 3", "refseq_ac": [ { "id": "NP_766192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766192", "type": "external" } ], "gene_names_uniprotkb": "Scara3", "gene_names_refseq": "APC7; C130058N24Rik; CSR1; CSR; MSLR1; MSRL1; Scara3", "protein_names_uniprotkb": "Scavenger receptor class A member 3", "protein_names_refseq": "scavenger receptor class A member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:219151)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;34254370;34428180", "class_list": "", "function": "Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1., [RefSeq, PubMed]; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9409, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6N1", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8C850-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDR2-1", "uniprot_id": [ { "id": "RSH6A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDR2", "type": "external" } ], "mass": 80202.0, "length": 708, "protein_name": "Radial spoke head protein 6 homolog A", "gene_name": "Rsph6a", "organism": "Mouse", "refseq_name": "radial spoke head protein 6 homolog A isoform 2", "refseq_ac": [ { "id": "NP_001153143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153143", "type": "external" } ], "gene_names_uniprotkb": "Rsph6a; Rshl1", "gene_names_refseq": "RSP4; Rshl1; Rsph6a", "protein_names_uniprotkb": "Radial spoke head protein 6 homolog A; Radial spoke head-like protein 1", "protein_names_refseq": "radial spoke head protein 6 homolog A isoform 2; radial spoke head protein 6 homolog A; radial spoke head-like protein 1; radial spokehead-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83434)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11237735;30185526;30239614;34871179;36417862", "class_list": "", "function": "Functions as part of radial spoke complexes in the axoneme of sperm flagella that play an important part in motility (PubMed:36417862). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:30185526, PubMed:30239614, PubMed:36417862)., [UniProtKB, PubMed, PubMed, PubMed]; The findings that Rsph6a is more phosphorylated during capacitation and is predicted to function in axonemal localization make Rsph6a a candidate protein mediating signaling processes in the sperm flagellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MM8;Q99MM9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium;GO:0001535 radial spoke head", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0035082 axoneme assembly;GO:0007618 mating;GO:1905199 manchette disassembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CDR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFJ7-1", "uniprot_id": [ { "id": "S2545_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFJ7", "type": "external" } ], "mass": 31690.0, "length": 288, "protein_name": "Methylated amino-acid transporter SLC25A45", "gene_name": "Slc25a45", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 45 isoform 1", "refseq_ac": [ { "id": "NP_598915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598915", "type": "external" } ], "gene_names_uniprotkb": "Slc25a45", "gene_names_refseq": "Slc25a45", "protein_names_uniprotkb": "Methylated amino-acid transporter SLC25A45; Solute carrier family 25 member 45", "protein_names_refseq": "solute carrier family 25 member 45 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107375)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19287344;21750661;34428180;37453647;41075780", "class_list": "", "function": "Mitochondrial transporter that specifically mediates the mitochondrial uptake of dimethylarginine and trimethyllysine amino acids, and which is required for carnitine biosynthesis (PubMed:41075780). Involved in carnitine biosynthesis by mediating the mitochondrial import of trimethyllysine, a precursor for carnitine biosynthesis (PubMed:41075780). Transports both symmetric and asymmetric dimethylarginine (By similarity). Does not transport unmethylated arginine and lysine (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC75;Q3UZE9;Q8VBZ7", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CFJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZR6-1", "uniprot_id": [ { "id": "S4A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZR6", "type": "external" } ], "mass": 122421.0, "length": 1089, "protein_name": "Electroneutral sodium bicarbonate exchanger 1", "gene_name": "Slc4a8", "organism": "Mouse", "refseq_name": "electroneutral sodium bicarbonate exchanger 1 isoform 2", "refseq_ac": [ { "id": "NP_001334031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334031", "type": "external" } ], "gene_names_uniprotkb": "Slc4a8; Kiaa0739; Ndcbe", "gene_names_refseq": "C230026C11; NDCBE; Slc4a8; kNBC-3", "protein_names_uniprotkb": "Electroneutral sodium bicarbonate exchanger 1; Electroneutral Na+-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3", "protein_names_refseq": "electroneutral Na+-driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1 isoform 2; electroneutral sodium bicarbonate exchanger 1; k-NBC3; solute carrier family 4 member 8", "tax_id": 10090, "disease": "prediabetes syndrome (Disease Ontology:DOID:11716); anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:59033); (R-MMU-425381)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11260402;18359573;18775686;20389022;21593314;21750661;30355950;34428180;34678516;38674160", "class_list": "", "function": "K[+]-Driven Cl[-]/HCO3[-] Exchange Mediated by Slc4a8 and Slc4a10. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:20389022). Plays a major role in pH regulation in neurons (PubMed:21593314). Mediates sodium reabsorption in the renal cortical collecting ducts (PubMed:20389022)., [UniProtKB, PubMed, PubMed]; Mouse brain exhibits marked developmental differences in the response of NDCBE protein expression to chronic continuous hypoxia, [RefSeq, PubMed]; Thus, SLC4A8 is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAV7;Q6A004;Q8BYI7;Q9JKV6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0015081 sodium ion transmembrane transporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097457 hippocampal mossy fiber;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:2000302 positive regulation of synaptic vesicle exocytosis;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8JZR6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0H1-1", "uniprot_id": [ { "id": "S47A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0H1", "type": "external" } ], "mass": 61642.0, "length": 567, "protein_name": "Multidrug and toxin extrusion protein 1", "gene_name": "Slc47a1", "organism": "Mouse", "refseq_name": "multidrug and toxin extrusion protein 1", "refseq_ac": [ { "id": "NP_080459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080459", "type": "external" } ], "gene_names_uniprotkb": "Slc47a1; Mate1", "gene_names_refseq": "1300013J15Rik; MATE1; Slc47a1; mMATE1", "protein_names_uniprotkb": "Multidrug and toxin extrusion protein 1; MATE-1; Solute carrier family 47 member 1; mMATE-1", "protein_names_refseq": "MATE-1; mMATE-1; multidrug and toxin extrusion protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67473); (R-MMU-549127)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16330770;16641166;17983590;18573474;19332510;21183079;21750661;24961373;30084848;34428180;36943799", "class_list": "", "function": "MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity., [RefSeq, PubMed]; MATE1 mRNA levels were highest in the kidney, where male expression was higher than female., [RefSeq, PubMed]; MMATE1 is polyspecific H(+)/(organic cation)OC exchanger. Unexpectedly wide distribution of mMATE1 suggests involvement in diverse biological functions other than excretion of OCs from the body. (Multidrug and toxin extrusion 1, MATE1), [RefSeq, PubMed]; MMATE1b is a functional variant of mMATE1 and seems to be the true counterpart to other MATE1 transporters, [RefSeq, PubMed]; Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16641166, PubMed:19332510). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (By similarity). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (By similarity). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; This is the first report to demonstrate an essential role of MATE1 in systemic clearance of metformin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SS45;Q9CQ64", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015234 thiamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0015695 organic cation transport;GO:0055085 transmembrane transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K0H1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K299-1", "uniprot_id": [ { "id": "SCAR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K299", "type": "external" } ], "mass": 53667.0, "length": 491, "protein_name": "Scavenger receptor class A member 5", "gene_name": "Scara5", "organism": "Mouse", "refseq_name": "scavenger receptor class A member 5 isoform 2", "refseq_ac": [ { "id": "NP_001161790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161790", "type": "external" } ], "gene_names_uniprotkb": "Scara5", "gene_names_refseq": "4932433F15Rik; 4933425F03Rik; Scara5; Tesr", "protein_names_uniprotkb": "Scavenger receptor class A member 5", "protein_names_refseq": "scavenger receptor class A member 5 isoform 2; scavenger receptor class A, member 5 (putative); testis expressed scavenger receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71145)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16245330;16407294;19154717;25259650;29093466;32907880;34428180", "class_list": "", "function": "Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery., [RefSeq, PubMed]; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1)., [UniProtKB, PubMed, HAMAP]; Interactions of ferritin with scavenger receptor class A members., [RefSeq, PubMed]; Scara5 was downregulated, pointing out this receptor as a potential player implicated in retinopathy and also as a possible therapeutic target. Erratum:[PLoS One. 2017 Jun 22;12(6):e0180288. doi: 10.1371/journal.pone.0180288. PMID: 28640867] Publication Status: Online-Only, [RefSeq, PubMed]; Tesr is differentially expressed in the male vs. female embryonic and postnatal gonad, and may play a role in phagocytosis of apoptotic cells, cell-cell adhesion, and defense. [Tesr - testis expressed scavenger receptor], [RefSeq, PubMed]; This study demonstrates that SCARA5 is a positive regulator in adipocyte lineage commitment and early adipogenesis in mesenchymal stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZZ2;Q8R330;Q91WD6;Q9CUC3;Q9D4G8", "ec_number_list": [], "go_molecular_function": "GO:0070287 ferritin receptor activity;GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030666 endocytic vesicle membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006897 endocytosis;GO:0006879 intracellular iron ion homeostasis;GO:0034605 cellular response to heat;GO:0070207 protein homotrimerization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K299-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62158-1", "uniprot_id": [ { "id": "TRI27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62158", "type": "external" } ], "mass": 58513.0, "length": 513, "protein_name": "Zinc finger protein RFP", "gene_name": "Trim27", "organism": "Mouse", "refseq_name": "zinc finger protein RFP isoform 1", "refseq_ac": [ { "id": "NP_033080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033080", "type": "external" } ], "gene_names_uniprotkb": "Trim27; Rfp", "gene_names_refseq": "Gm19403; Rfp; Trim27", "protein_names_uniprotkb": "Zinc finger protein RFP; 2.3.2.27; Ret finger protein; Tripartite motif-containing protein 27", "protein_names_refseq": "RING-type E3 ubiquitin transferase TRIM27; ret finger protein; tripartite motif protein 27; tripartite motif-containing protein 27; zinc finger protein RFP isoform 1; zinc finger protein RFP", "tax_id": 10090, "disease": "", "pathway": " (mmu:19720); (R-MMU-3232142); (R-MMU-8948751)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10571821;1437549;21750661;24144979;25428506;26365382;30084848;31219806;34428180;35962797;37914066;38146129;9023983", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:24144979). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation (By similarity). Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (By similarity). Has a transcriptional repressor activity by cooperating with EPC1 (By similarity). Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events (By similarity). May function in male germ cell development (By similarity). Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity). Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (By similarity). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (By similarity). Alternatively, facilitates mitophagy via TBK1 activation (By similarity). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (By similarity). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (By similarity)., [UniProtKB, UniProtKB, PubMed]; Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARgamma and reducing NOX4 expression., [RefSeq, PubMed]; METTL14 promotes IL-6-induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27., [RefSeq, PubMed]; TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62157;Q8C2Q5;Q99LK1", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62158-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6H3-1", "uniprot_id": [ { "id": "K7N6H3_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6H3", "type": "external" } ], "mass": 55970.0, "length": 473, "protein_name": "Zinc finger protein 934", "gene_name": "Zfp934", "organism": "Mouse", "refseq_name": "zinc finger protein 782 isoform 1", "refseq_ac": [ { "id": "NP_001156383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156383", "type": "external" } ], "gene_names_uniprotkb": "Zfp934", "gene_names_refseq": "6720457D02Rik; Zfp934", "protein_names_uniprotkb": "Zinc finger protein 934", "protein_names_refseq": "zinc finger protein 782 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77117); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6H3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R314-1", "uniprot_id": [ { "id": "S35F5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R314", "type": "external" } ], "mass": 58613.0, "length": 524, "protein_name": "Solute carrier family 35 member F5", "gene_name": "Slc35f5", "organism": "Mouse", "refseq_name": "solute carrier family 35 member F5 isoform 1", "refseq_ac": [ { "id": "NP_083063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083063", "type": "external" } ], "gene_names_uniprotkb": "Slc35f5", "gene_names_refseq": "1300003P13Rik; Slc35f5", "protein_names_uniprotkb": "Solute carrier family 35 member F5", "protein_names_refseq": "solute carrier family 35 member F5 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74150)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;36210013", "class_list": "", "function": "Mediates choline transport, although the underlying transport mechanism remains to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBK9", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R314-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZZ5-1", "uniprot_id": [ { "id": "RXFP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "type": "external" } ], "mass": 82934.0, "length": 737, "protein_name": "Relaxin receptor 2", "gene_name": "Rxfp2", "organism": "Mouse", "refseq_name": "relaxin receptor 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493", "type": "external" } ], "gene_names_uniprotkb": "Rxfp2; Gpr106; Great; Lgr8", "gene_names_refseq": "Gpr106; Great; Lgr8; Rxfp2", "protein_names_uniprotkb": "Relaxin receptor 2; G protein-coupled receptor 106; G protein-coupled receptor affecting testicular descent; Leucine-rich repeat-containing G protein-coupled receptor 8; Relaxin family peptide receptor 2", "protein_names_refseq": "G protein coupled receptor affecting testicular descent; G protein-coupled receptor 106; leucine-rich repeat-containing G protein-coupled receptor 8; relaxin receptor 2 isoform 2 precursor; relaxin receptor 2", "tax_id": 10090, "disease": "cryptorchidism (Disease Ontology:DOID:11383)", "pathway": " (mmu:140498); (R-MMU-418555); (R-MMU-444821)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11353515;12933905;14666470;21750661", "class_list": "", "function": "Disruption of the Greatgene causes failure of the transabdominal phase of descent, identical to that seen in the Insl3-deficient mutants, consistent with the recent data suggesting that Great gene encodes the Insl3 transmembrane receptor., [RefSeq, PubMed]; Insulin-like 3 peptide or great cause cryptorchidism (undescended testes) in mice., [RefSeq, PubMed]; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB90", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91ZZ5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTM5-1", "uniprot_id": [ { "id": "RUVB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTM5", "type": "external" } ], "mass": 51113.0, "length": 463, "protein_name": "RuvB-like 2", "gene_name": "Ruvbl2", "organism": "Mouse", "refseq_name": "ruvB-like 2 isoform a", "refseq_ac": [ { "id": "NP_035434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035434", "type": "external" } ], "gene_names_uniprotkb": "Ruvbl2", "gene_names_refseq": "Ruvbl2; mp47; p47", "protein_names_uniprotkb": "RuvB-like 2; 3.6.4.12; p47 protein", "protein_names_refseq": "RuvB-like protein 2; reptin; ruvB-like 2 isoform a; ruvB-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20174)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10220587;16425234;21750661;26495903;28011936;28935714;29187734;30084848;37453647;37507081;38609375", "class_list": "", "function": "Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). May also inhibit the transcriptional activity of ATF2 (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity)., [UniProtKB, UniProtKB]; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RUVBL1 ubiquitination by DTL promotes RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051117 ATPase binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9WTM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0M8-1", "uniprot_id": [ { "id": "S35A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0M8", "type": "external" } ], "mass": 40766.0, "length": 390, "protein_name": "UDP-galactose translocator", "gene_name": "Slc35a2", "organism": "Mouse", "refseq_name": "UDP-galactose translocator isoform 2", "refseq_ac": [ { "id": "NP_001077406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077406", "type": "external" } ], "gene_names_uniprotkb": "Slc35a2; Ugt1", "gene_names_refseq": "Had-1; Had1; Sfc8; Slc35a2; UGT; Ugalt", "protein_names_uniprotkb": "UDP-galactose translocator; Solute carrier family 35 member A2; UDP-Gal-Tr; UDP-galactose transporter; UGT; mUGT1", "protein_names_refseq": "UDP-Gal-Tr; UDP-galactose translocator isoform 2; UDP-galactose translocator; mUGT1; solute carrier family (UDP-N-acetylglucosamine transporter), member 2; solute carrier family 35 (UDP-galactose transporter) member 2; solute carrier family 35 (UDP-galactose transporter), member 2; solute carrier family 35 member A2", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIm (Disease Ontology:DOID:0070265); bacterial infectious disease (Disease Ontology:DOID:104)", "pathway": " (mmu:22232); (R-MMU-727802)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10578063;21750661;22159897;25428506;30084848;34428180;35820727;36454514;38909838", "class_list": "glycogene", "function": "DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams., [RefSeq, PubMed]; Loss of Slc35a2 alters development of the mouse cerebral cortex., [RefSeq, PubMed]; Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation., [RefSeq, PubMed]; Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into the Golgi apparatus (PubMed:10578063). It functions as an antiporter that exchanges UDP-galactose for UMP (By similarity). It is also able to exchange UDP-galactose for AMP and CMP, and to transport UDP-N-acetylgalactosamine (UDP-GalNAc) and other nucleotide sugars (By similarity). As a provider of UDP-galactose to galactosyltransferases present in the Golgi apparatus, it is necessary for globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005459 UDP-galactose transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072334 UDP-galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R0M8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N87-1", "uniprot_id": [ { "id": "RT05_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N87", "type": "external" } ], "mass": 48207.0, "length": 432, "protein_name": "Small ribosomal subunit protein uS5m", "gene_name": "Mrps5", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS5m", "refseq_ac": [ { "id": "NP_084239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084239", "type": "external" } ], "gene_names_uniprotkb": "Mrps5", "gene_names_refseq": "1620401I16Rik; Mrps5", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5m; 28S ribosomal protein S5, mitochondrial; MRP-S5; S5mt", "protein_names_refseq": "28S ribosomal protein S5, mitochondrial; MRP-S5; S5mt; small ribosomal subunit protein uS5m", "tax_id": 10090, "disease": "", "pathway": " (mmu:77721); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11402041;21750661;31219806;35457201;35820727", "class_list": "", "function": "Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99N87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4C2-1", "uniprot_id": [ { "id": "RUFY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4C2", "type": "external" } ], "mass": 70093.0, "length": 606, "protein_name": "RUN and FYVE domain-containing protein 2", "gene_name": "Rufy2", "organism": "Mouse", "refseq_name": "RUN and FYVE domain-containing protein 2", "refseq_ac": [ { "id": "NP_081701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081701", "type": "external" } ], "gene_names_uniprotkb": "Rufy2; Kiaa1537", "gene_names_refseq": "2610111M19Rik; Denn; LZ-FYVE; Rufy2; ZFYVE13", "protein_names_uniprotkb": "RUN and FYVE domain-containing protein 2; LZ-FYVE; Leucine zipper FYVE-finger protein", "protein_names_refseq": "RUN and FYVE domain-containing protein 2; leucine zipper FYVE-finger protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70432)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11506704;11877430;21750661;25428506;25605945;30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZH1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R4C2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9V4-1", "uniprot_id": [ { "id": "RSPH9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9V4", "type": "external" } ], "mass": 31331.0, "length": 276, "protein_name": "Radial spoke head protein 9 homolog", "gene_name": "Rsph9", "organism": "Mouse", "refseq_name": "radial spoke head protein 9 homolog", "refseq_ac": [ { "id": "NP_083614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083614", "type": "external" } ], "gene_names_uniprotkb": "Rsph9", "gene_names_refseq": "1700027N10Rik; Rsph9", "protein_names_uniprotkb": "Radial spoke head protein 9 homolog", "protein_names_refseq": "radial spoke head protein 9 homolog", "tax_id": 10090, "disease": "primary ciliary dyskinesia 12 (Disease Ontology:DOID:0110601)", "pathway": " (mmu:75564)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19200523;21750661;30383886;32203505;32709945;34871179;36417862", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:30383886, PubMed:34871179, PubMed:36417862). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (PubMed:30383886). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Rsph9 was specifically expressed in mouse tissues containing motile cilia and upregulated during multiciliation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:1904158 axonemal central apparatus assembly;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0044458 motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D9V4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPR1-1", "uniprot_id": [ { "id": "RWDD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPR1", "type": "external" } ], "mass": 21138.0, "length": 188, "protein_name": "RWD domain-containing protein 4", "gene_name": "Rwdd4a; Rwdd4", "organism": "Mouse", "refseq_name": "RWD domain-containing protein 4", "refseq_ac": [ { "id": "NP_987103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_987103", "type": "external" } ], "gene_names_uniprotkb": "Rwdd4a; Rwdd4; Rwdd4a", "gene_names_refseq": "Gm1942; Rwdd4a; Rwdd4", "protein_names_uniprotkb": "RWD domain-containing protein 4", "protein_names_refseq": "RWD domain-containing protein 4A; RWD domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:192174)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CPR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI02-1", "uniprot_id": [ { "id": "S2B20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI02", "type": "external" } ], "mass": 12590.0, "length": 112, "protein_name": "Secretoglobin family 2B member 20", "gene_name": "Scgb2b20", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scgb2b20; Abpd", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretoglobin family 2B member 20; Allergen dI chain C2C; Androgen-binding protein delta; Lacrimal androgen-binding protein delta", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:494519)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12406855;15623751;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M746", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JI02-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5A4-1", "uniprot_id": [ { "id": "RSLAA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K5A4", "type": "external" } ], "mass": 22792.0, "length": 203, "protein_name": "Ras-like protein family member 10A", "gene_name": "Rasl10a", "organism": "Mouse", "refseq_name": "ras-like protein family member 10A isoform 1", "refseq_ac": [ { "id": "NP_660251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660251", "type": "external" } ], "gene_names_uniprotkb": "Rasl10a; Rrp22", "gene_names_refseq": "2210403B10Rik; Rasl10a", "protein_names_uniprotkb": "Ras-like protein family member 10A; 3.6.5.2; Ras-like protein RRP22; Ras-related protein on chromosome 22 homolog", "protein_names_refseq": "Ras-like protein RRP22 (RAS-related protein on chromosome 22); ras-like protein family member 10A isoform 1; ras-like protein family member 10A; ras-related protein on chromosome 22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potent inhibitor of cellular proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNN0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K5A4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0C3-1", "uniprot_id": [ { "id": "S26A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0C3", "type": "external" } ], "mass": 112978.0, "length": 999, "protein_name": "Testis anion transporter 1", "gene_name": "Slc26a8", "organism": "Mouse", "refseq_name": "testis anion transporter 1 isoform 1", "refseq_ac": [ { "id": "NP_001277249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277249", "type": "external" } ], "gene_names_uniprotkb": "Slc26a8; Tat1", "gene_names_refseq": "Slc26a8", "protein_names_uniprotkb": "Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8", "protein_names_refseq": "anion exchange transporter; testis anion transporter 1 isoform 1; testis anion transporter 1", "tax_id": 10090, "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168)", "pathway": " (mmu:224661)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17517695;21750661;22121115;35181959", "class_list": "glycogene", "function": "Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR (By similarity). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (PubMed:22121115). May play a role in sperm tail differentiation and motility and hence male fertility (PubMed:17517695)., [UniProtKB, UniProtKB, PubMed, PubMed]; Tat1 (Slc26A8) is a critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility, [RefSeq, PubMed]; The heterozygous mutations of SLC26A8 are not the main actors for male infertility., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 63, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0160044 sulfate:chloride antiporter activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R0C3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIG3-1", "uniprot_id": [ { "id": "RSPH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIG3", "type": "external" } ], "mass": 34181.0, "length": 301, "protein_name": "Radial spoke head 1 homolog", "gene_name": "Rsph1", "organism": "Mouse", "refseq_name": "radial spoke head 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_079566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079566", "type": "external" } ], "gene_names_uniprotkb": "Rsph1; Tsga2", "gene_names_refseq": "MCA; Rsph1; Tsga2", "protein_names_uniprotkb": "Radial spoke head 1 homolog; Male meiotic metaphase chromosome-associated acidic protein; Meichroacidin; Testis-specific gene A2 protein", "protein_names_refseq": "male meiotic metaphase chromosome-associated acidic protein; meichroacidin; radial spoke head 1 homolog isoform 1; testis-specific gene A2 protein", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary ciliary dyskinesia 24 (Disease Ontology:DOID:0110628)", "pathway": " (mmu:22092)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16354795;21750661;32203505;34231842;34871179;36417862;9578619", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Tsga2 fulfills many of the prerequisites required to make it a strong candidate for Ccub1, an element of Cucb positioned within a genomic interval spanning approximately 0.6 Mb immediately distal to Dnahc8., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAL5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0001520 outer dense fiber;GO:0000794 condensed nuclear chromosome;GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0003341 cilium movement;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VIG3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W10-1", "uniprot_id": [ { "id": "S39A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W10", "type": "external" } ], "mass": 50082.0, "length": 462, "protein_name": "Metal cation symporter ZIP8", "gene_name": "Slc39a8", "organism": "Mouse", "refseq_name": "metal cation symporter ZIP8 precursor", "refseq_ac": [ { "id": "NP_001128621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128621", "type": "external" } ], "gene_names_uniprotkb": "Slc39a8; Zip8", "gene_names_refseq": "4933419D20Rik; BIGM103; Slc39a8; ZIP-8; Zip8", "protein_names_uniprotkb": "Metal cation symporter ZIP8; Solute carrier family 39 member 8; ZIP-8; Zrt- and Irt-like protein 8", "protein_names_refseq": "Zrt- and Irt-like protein 8; metal cation symporter ZIP8 precursor; metal cation symporter ZIP8; zinc transporter ZIP8", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); left ventricular noncompaction (Disease Ontology:DOID:0060480); congenital disorder of glycosylation type IIn (Disease Ontology:DOID:0070266)", "pathway": " (mmu:67547); (R-MMU-442380)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "15722412;16638970;17108009;18037372;20485683;22563477;22898811;23403290;24529376;27166256;28481222;29337306;29927450;30015240;38839750;39435657", "class_list": "", "function": "Cd treatment caused acute renal failure and signs of proximal tubular damage in the BTZIP8-3 but not nontransgenic littermates. BTZIP8-3 mice should be a useful model for studying Cd-induced disease in kidney., [RefSeq, PubMed]; Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:16638970, PubMed:18037372, PubMed:22563477, PubMed:29337306). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:16638970, PubMed:18037372, PubMed:22563477, PubMed:27166256). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:15722412, PubMed:16638970, PubMed:17108009, PubMed:18037372, PubMed:24529376). May also transport iron and cobalt through membranes (PubMed:16638970, PubMed:22898811, PubMed:24529376). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:24529376, PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290). Protects, for instance, cells from injury and death at the onset of inflammation (By similarity). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (PubMed:30015240). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (By similarity). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain. With manganese cellular uptake also participates in mitochondrial proper function (By similarity). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTQ3;Q8BUD6;Q9D426;Q9D5V4", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140412 zinc:bicarbonate symporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0006351 DNA-templated transcription;GO:0030198 extracellular matrix organization;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q91W10-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WN3-1", "uniprot_id": [ { "id": "S7A13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WN3", "type": "external" } ], "mass": 53233.0, "length": 478, "protein_name": "Solute carrier family 7 member 13", "gene_name": "Slc7a13", "organism": "Mouse", "refseq_name": "solute carrier family 7 member 13", "refseq_ac": [ { "id": "NP_083022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083022", "type": "external" } ], "gene_names_uniprotkb": "Slc7a13; Agt1; Xat2", "gene_names_refseq": "0610009O04Rik; AGT-1; AGT1; Slc7a13; XAT2", "protein_names_uniprotkb": "Solute carrier family 7 member 13; Sodium-independent aspartate/glutamate transporter 1; X-amino acid transporter 2", "protein_names_refseq": "X-amino acid transporter 2; aspartate/glutamate transporter 1; sodium-independent aspartate/glutamate transporter 1; solute carrier family 7 member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:74087)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11907033;11943479;26739563", "class_list": "", "function": "A membrane protein AGT1/SLC7A13 is the second partner of rBAT., [RefSeq, PubMed]; Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0046982 protein heterodimerization activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015811 L-cystine transport;GO:0003333 amino acid transmembrane transport;GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91WN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NH7-1", "uniprot_id": [ { "id": "S26A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NH7", "type": "external" } ], "mass": 81337.0, "length": 744, "protein_name": "Prestin", "gene_name": "Slc26a5", "organism": "Mouse", "refseq_name": "prestin isoform 2", "refseq_ac": [ { "id": "NP_001276716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276716", "type": "external" } ], "gene_names_uniprotkb": "Slc26a5; Pres", "gene_names_refseq": "Pres; Slc26a5; prestin", "protein_names_uniprotkb": "Prestin; Solute carrier family 26 member 5", "protein_names_refseq": "outer hair cell motor protein; prestin (motor protein); prestin isoform 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 61 (Disease Ontology:DOID:0110513); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:80979)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12239568;12584604;12782792;14553901;21750661;33951436", "class_list": "glycogene", "function": "Although prestin is expressed in vestibular hair cells, it is unlikely that it supports the form of somatic motility observed in outer hair cells., [RefSeq, PubMed]; Genomic characterization and expression of mouse prestin, [RefSeq, PubMed]; Targeted deletion of prestin in mice results in loss of outer hair cell electromotility in vitro and a 40-60 dB loss of cochlear sensitivity in vivo, without disruption of mechano-electrical transduction in outer hair cells, [RefSeq, PubMed]; Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ (PubMed:12239568). Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane (PubMed:12239568). The nature of the voltage sensor is not completely clear, and two models compete (By similarity). In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC (By similarity). The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC) (By similarity). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion) (By similarity). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization (By similarity). The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding (By similarity). Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and therefore inhibits the charge transfer and electromotility by displacing Cl(-) from the anion-binding site and by preventing the structural transitions to the contracted state (By similarity). In addition, can act as a weak Cl(-)/HCO3(-) antiporter across the cell membrane and so regulate the intracellular pH of the outer hair cells (OHCs), while firstly found as being unable to mediate electrogenic anion transport (By similarity). Moreover, supports a role in cardiac mechanical amplification serving as an elastic element to enhance the actomyosin- based sarcomere contraction system (PubMed:33951436)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZB1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030507 spectrin binding;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016328 lateral plasma membrane;GO:0120249 lateral wall of outer hair cell;GO:0016020 membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0019532 oxalate transport;GO:0002931 response to ischemia;GO:0042391 regulation of membrane potential;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99NH7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPX7-1", "uniprot_id": [ { "id": "RT16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPX7", "type": "external" } ], "mass": 15192.0, "length": 135, "protein_name": "Small ribosomal subunit protein bS16m", "gene_name": "Mrps16", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein bS16m precursor", "refseq_ac": [ { "id": "NP_079716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079716", "type": "external" } ], "gene_names_uniprotkb": "Mrps16; Rpms16", "gene_names_refseq": "1500011E11Rik; Mprs16; Mrps16; S16mt", "protein_names_uniprotkb": "Small ribosomal subunit protein bS16m; 28S ribosomal protein S16, mitochondrial; MRP-S16; S16mt", "protein_names_refseq": "28S ribosomal protein S16, mitochondrial; small ribosomal subunit protein bS16m precursor; small ribosomal subunit protein bS16m", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 2 (Disease Ontology:DOID:0111483)", "pathway": " (mmu:66242); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11402041;31219806;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CPX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0G0-1", "uniprot_id": [ { "id": "RT30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0G0", "type": "external" } ], "mass": 49939.0, "length": 442, "protein_name": "Large ribosomal subunit protein mL65", "gene_name": "Mrps30", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL65", "refseq_ac": [ { "id": "NP_067531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067531", "type": "external" } ], "gene_names_uniprotkb": "Mrps30", "gene_names_refseq": "2610020A16Rik; Mrps30; PAP; Pdcd9", "protein_names_uniprotkb": "Large ribosomal subunit protein mL65; 28S ribosomal protein S30, mitochondrial; MRP-S30; S30mt", "protein_names_refseq": "28S ribosomal protein S30, mitochondrial; MRP-S30; S30mt; large ribosomal subunit protein mL65; programmed cell death 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:59054); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KF79;Q3U9U4;Q9CYS8;Q9JJQ2", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D0G0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D125-1", "uniprot_id": [ { "id": "RT25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D125", "type": "external" } ], "mass": 19920.0, "length": 171, "protein_name": "Small ribosomal subunit protein mS25", "gene_name": "Mrps25", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS25", "refseq_ac": [ { "id": "NP_079854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079854", "type": "external" } ], "gene_names_uniprotkb": "Mrps25; Rpms25", "gene_names_refseq": "2810429N01Rik; Mrps25; Rpms25", "protein_names_uniprotkb": "Small ribosomal subunit protein mS25; 28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt", "protein_names_refseq": "28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt; small ribosomal subunit protein mS25", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 50 (Disease Ontology:DOID:0112111)", "pathway": " (mmu:64658); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYY8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D125-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2X5-1", "uniprot_id": [ { "id": "SCC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2X5", "type": "external" } ], "mass": 69579.0, "length": 619, "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "Mau2", "organism": "Mouse", "refseq_name": "MAU2 chromatid cohesion factor homolog isoform 1", "refseq_ac": [ { "id": "NP_001161411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161411", "type": "external" } ], "gene_names_uniprotkb": "Mau2; Kiaa0892; Scc4", "gene_names_refseq": "9130404D08Rik; A930019L04Rik; Mau-2; Mau2; mKIAA0892", "protein_names_uniprotkb": "MAU2 chromatid cohesion factor homolog; Cohesin loading complex subunit SCC4 homolog; MAU-2", "protein_names_refseq": "MAU2 chromatid cohesion factor homolog isoform 1; MAU2 chromatid cohesion factor homolog; Scc4-like protein; cohesin loading complex subunit SCC4 homolog; protein MAU-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74549); (R-MMU-2470946)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;24287868;24700590;25428506;31219806;34428180;39742660", "class_list": "", "function": "Absence of Mau2 in neural crest cells causes a severe disruption of craniofacial development., [RefSeq, PubMed]; In spermatocytes, Nipbl/Mau2 then relocalises to chromocenters, whereas in oocytes it remains bound to chromosomal axes throughout prophase to dictyate arrest., [RefSeq, PubMed]; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN38;Q059Q4;Q5DU12;Q78IR4;Q8BUW9;Q8BX04", "ec_number_list": [], "go_molecular_function": "GO:0061775 cohesin loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0032116 SMC loading complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007064 mitotic sister chromatid cohesion;GO:0034088 maintenance of mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D2X5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6X5-1", "uniprot_id": [ { "id": "S52A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6X5", "type": "external" } ], "mass": 49559.0, "length": 460, "protein_name": "Solute carrier family 52, riboflavin transporter, member 3", "gene_name": "Slc52a3", "organism": "Mouse", "refseq_name": "solute carrier family 52, riboflavin transporter, member 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001158291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158291", "type": "external" } ], "gene_names_uniprotkb": "Slc52a3; RFVT3; Rft2", "gene_names_refseq": "2310046K01Rik; RFT2; Slc52a3", "protein_names_uniprotkb": "Solute carrier family 52, riboflavin transporter, member 3; RFT2; Riboflavin transporter 2", "protein_names_refseq": "riboflavin transporter 2; solute carrier family 52, riboflavin transporter, member 3 isoform 1 precursor; solute carrier family 52, riboflavin transporter, member 3", "tax_id": 10090, "disease": "Brown-Vialetto-Van Laere syndrome (Disease Ontology:DOID:0050694); Fazio-Londe disease (Disease Ontology:DOID:0080632); Brown-Vialetto-Van Laere syndrome 1 (Disease Ontology:DOID:0080785)", "pathway": " (mmu:69698); (R-MMU-196843)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;24264046;25428506;26660539;26976849;27272163;30084848;33116204", "class_list": "", "function": "Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of Slc52a3 gene is associated with Brown-Vialetto-van Laere syndrome., [RefSeq, PubMed]; Our knowledge, this is the first report to indicate that Rfvt3 contributes to placental riboflavin transport, and that disruption of Slc52a3 gene caused neonatal mortality with hyperlipidemia and hypoglycemia owing to riboflavin deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism., [UniProtKB, UniProtKB]; The RFVT-3 system is the main transporter involved in carrier-mediated riboflavin uptake in the native mouse small and large intestine, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AQU3;Q3TDJ6;Q3U328;Q8CE36;Q91WB9", "ec_number_list": [], "go_molecular_function": "GO:0032217 riboflavin transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0007605 sensory perception of sound;GO:0032218 riboflavin transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D6X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9S3-1", "uniprot_id": [ { "id": "RWD2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9S3", "type": "external" } ], "mass": 33916.0, "length": 292, "protein_name": "RWD domain-containing protein 2A", "gene_name": "Rwdd2a", "organism": "Mouse", "refseq_name": "RWD domain-containing protein 2A", "refseq_ac": [ { "id": "NP_001139441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139441", "type": "external" } ], "gene_names_uniprotkb": "Rwdd2a; Rwdd2", "gene_names_refseq": "1700030C20Rik; Rwdd2a; Rwdd2", "protein_names_uniprotkb": "RWD domain-containing protein 2A", "protein_names_refseq": "RWD domain containing 2; RWD domain-containing protein 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:69519)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC71-1", "uniprot_id": [ { "id": "RT15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC71", "type": "external" } ], "mass": 29464.0, "length": 258, "protein_name": "Small ribosomal subunit protein uS15m", "gene_name": "Mrps15", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS15m precursor", "refseq_ac": [ { "id": "NP_079820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079820", "type": "external" } ], "gene_names_uniprotkb": "Mrps15; Rpms15", "gene_names_refseq": "1500003E24Rik; 2410002B11Rik; Mprs15; Mrps15", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15m; 28S ribosomal protein S15, mitochondrial; MRP-S15; S15mt", "protein_names_refseq": "28S ribosomal protein S15, mitochondrial; MRP-S15; S15mt; small ribosomal subunit protein uS15m precursor; small ribosomal subunit protein uS15m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66407); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11402041;31487196;37507081", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMG9;Q8C7F1;Q9CVE0;Q9CWX1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DC71-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER88-1", "uniprot_id": [ { "id": "RT29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER88", "type": "external" } ], "mass": 44699.0, "length": 391, "protein_name": "Small ribosomal subunit protein mS29", "gene_name": "Dap3", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS29 isoform 1", "refseq_ac": [ { "id": "NP_001158005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158005", "type": "external" } ], "gene_names_uniprotkb": "Dap3; Mrps29", "gene_names_refseq": "4921514D13Rik; DAP-3; Dap3; MRP-S29; S29mt", "protein_names_uniprotkb": "Small ribosomal subunit protein mS29; 28S ribosomal protein S29, mitochondrial; 3.6.5.-; DAP-3; Death-associated protein 3; MRP-S29; S29mt", "protein_names_refseq": "28S ribosomal protein S29, mitochondrial; small ribosomal subunit protein mS29 isoform 1; small ribosomal subunit protein mS29", "tax_id": 10090, "disease": "Perrault syndrome 7 (Disease Ontology:DOID:0061073)", "pathway": " (mmu:65111); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11017876;15175341;16075062;17056041;21750661;26306039;37453647", "class_list": "", "function": "As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs. Involved in mediating interferon-gamma-induced cell death. Displays GTPase activity in vitro., [UniProtKB, UniProtKB]; DAP3 has a role in the molecular pathway that culminates in fragmented mitochondria, [RefSeq, PubMed]; DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction., [RefSeq, PubMed]; DAP3 plays important roles in mitochondrial function and dynamics, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2B2;Q8CCQ8;Q8VCK8;Q9CRT4;Q9CS11;Q9D5V9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008637 apoptotic mitochondrial changes;GO:0032543 mitochondrial translation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ER88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R155-1", "uniprot_id": [ { "id": "S26A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R155", "type": "external" } ], "mass": 85687.0, "length": 780, "protein_name": "Pendrin", "gene_name": "Slc26a4", "organism": "Mouse", "refseq_name": "pendrin", "refseq_ac": [ { "id": "NP_035997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035997", "type": "external" } ], "gene_names_uniprotkb": "Slc26a4; Pds", "gene_names_refseq": "Pds; Slc26a4; pendrin", "protein_names_uniprotkb": "Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4", "protein_names_refseq": "pendrin; sodium-independent chloride/iodide transporter", "tax_id": 10090, "disease": "Pendred Syndrome (Disease Ontology:DOID:0060744); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); goiter (Disease Ontology:DOID:12176)", "pathway": " (mmu:23985); (R-MMU-427601)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10449762;11274445;11459928;18565999;25605945;35601831", "class_list": "glycogene", "function": "Sodium-independent transporter of chloride and iodide (By similarity). Mediates electroneutral iodide-chloride, iodide-bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry (PubMed:11274445, PubMed:18565999). Mediates elctroneutral chloride-formate exchange (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015111 iodide transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0009887 animal organ morphogenesis;GO:0015705 iodide transport;GO:1902476 chloride transmembrane transport;GO:0015698 inorganic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R155-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VJN6-1", "uniprot_id": [ { "id": "A0A1Y7VJN6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJN6", "type": "external" } ], "mass": 44010.0, "length": 399, "protein_name": "Immunoglobulin heavy constant gamma 3", "gene_name": "Ighg3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighg3", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant gamma 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-977606)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "21750661;36064721", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0034988 Fc-gamma receptor I complex binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0042571 immunoglobulin complex, circulating;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0019731 antibacterial humoral response;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0050766 positive regulation of phagocytosis;GO:0006910 phagocytosis, recognition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A1Y7VJN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PUQ8-1", "uniprot_id": [ { "id": "DGKD_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PUQ8", "type": "external" } ], "mass": 135208.0, "length": 1220, "protein_name": "Diacylglycerol kinase delta", "gene_name": "Dgkd", "organism": "Mouse", "refseq_name": "diacylglycerol kinase delta", "refseq_ac": [ { "id": "NP_808314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808314", "type": "external" } ], "gene_names_uniprotkb": "Dgkd", "gene_names_refseq": "D330025K09; DGKdelta; Dgkd; dgkd-2", "protein_names_uniprotkb": "Diacylglycerol kinase delta; 2.7.1.107; DAG kinase delta", "protein_names_refseq": "DAG kinase delta; diacylglycerol kinase delta", "tax_id": 10090, "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561)", "pathway": " (mmu:227333); (R-MMU-114508)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17021016;21750661;22645316;24129315;25428506;30779550;31010675;38843995", "class_list": "", "function": "Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:17021016). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:17021016). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (PubMed:17021016). May also regulate clathrin-dependent endocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; SFA/MUFA-PAs produced by DGKdelta are novel regulators of CKM function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0006897 endocytosis;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9PUQ8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WQI7-1", "uniprot_id": [ { "id": "A0A087WQI7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WQI7", "type": "external" } ], "mass": 48029.0, "length": 412, "protein_name": "RIKEN cDNA B020011L13 gene", "gene_name": "B020011L13Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC547097", "refseq_ac": [ { "id": "NP_001423073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423073", "type": "external" } ], "gene_names_uniprotkb": "B020011L13Rik", "gene_names_refseq": "B020011L13Rik", "protein_names_uniprotkb": "RIKEN cDNA B020011L13 gene", "protein_names_refseq": "uncharacterized protein LOC547097", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-212436); 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In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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"", "protein_names_uniprotkb": "Predicted gene 14418", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ARR6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9G3-1", "uniprot_id": [ { "id": "E9Q9G3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9G3", "type": "external" } ], "mass": 67536.0, "length": 579, "protein_name": "Zinc finger protein 938", "gene_name": "Zfp938", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC237411 isoform 1", "refseq_ac": [ { "id": "NP_001099027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099027", "type": "external" } ], "gene_names_uniprotkb": "Zfp938", "gene_names_refseq": "B230315N10Rik; Zfp938", "protein_names_uniprotkb": "Zinc finger protein 938", "protein_names_refseq": "uncharacterized protein LOC237411 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:237411); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, 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"binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q9G3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PZR7-1", "uniprot_id": [ { "id": "E9PZR7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PZR7", "type": "external" } ], "mass": 34364.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r91", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 91", "refseq_ac": [ { "id": "NP_001160208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160208", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r91", "gene_names_refseq": "EG667067; Gm8442; Vmn1r91", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r91; vomeronasal 1 receptor 91", "tax_id": 10090, "disease": "", "pathway": " (mmu:667067)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PZR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q411-1", "uniprot_id": [ { "id": "E9Q411_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q411", "type": "external" } ], "mass": 265775.0, "length": 2356, "protein_name": "Neuroblastoma amplified sequence", "gene_name": "Nbas", "organism": "Mouse", "refseq_name": "NBAS subunit of NRZ tethering complex isoform 1", "refseq_ac": [ { "id": "NP_081982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081982", "type": "external" } ], "gene_names_uniprotkb": "Nbas", "gene_names_refseq": "4933425L03Rik; Nag; Nbas", "protein_names_uniprotkb": "Neuroblastoma amplified sequence", "protein_names_refseq": "NBAS subunit of NRZ tethering complex isoform 1; neuroblastoma-amplified protein", "tax_id": 10090, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716)", "pathway": " (R-MMU-6811434)", "pathway_count": 1, 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"reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9393, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0070939 Dsl1/NZR complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9Q411-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H3BLB0-1", "uniprot_id": [ { "id": "H3BLB0_MOUSE", "url": "https://www.uniprot.org/uniprot/H3BLB0", "type": "external" } ], "mass": 77463.0, "length": 661, "protein_name": "Zinc finger protein 989", "gene_name": "Zfp989", "organism": "Mouse", "refseq_name": "zinc finger protein 989", "refseq_ac": [ { "id": "NP_001423292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423292", "type": "external" } ], "gene_names_uniprotkb": "Zfp989", "gene_names_refseq": "Gm13150; Zfp989", "protein_names_uniprotkb": "Zinc finger protein 989", "protein_names_refseq": "zinc finger protein 989", "tax_id": 10090, "disease": "", "pathway": " (mmu:100502814); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 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binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "H3BLB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QM92-1", "uniprot_id": [ { "id": "J3QM92_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QM92", "type": "external" } ], "mass": 30412.0, "length": 274, "protein_name": "Phospholipid scramblase", "gene_name": "Plscr5", "organism": "Mouse", "refseq_name": "phospholipid scramblase family member 5", "refseq_ac": [ { "id": "NP_001182622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182622", "type": "external" } ], "gene_names_uniprotkb": "Plscr5", "gene_names_refseq": "331000; Plscr5", "protein_names_uniprotkb": "Phospholipid scramblase", "protein_names_refseq": "phospholipid scramblase family member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504689)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J9JI72-1", "uniprot_id": [ { "id": "J9JI72_MOUSE", "url": "https://www.uniprot.org/uniprot/J9JI72", "type": "external" } ], "mass": 85297.0, "length": 758, "protein_name": "PAS domain containing repressor 1", "gene_name": "Pasd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pasd1", "gene_names_refseq": "", "protein_names_uniprotkb": "PAS domain containing repressor 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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"reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0A6YWC7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JFH3-1", "uniprot_id": [ { "id": "A0A0G2JFH3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JFH3", "type": "external" } ], "mass": 35498.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or51a7", "organism": "Mouse", "refseq_name": "olfactory receptor 576", "refseq_ac": [ { "id": "NP_001001805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001805", "type": "external" } ], "gene_names_uniprotkb": "Or51a7; Olfr576", "gene_names_refseq": "MOR8-5; Olfr576-ps1; Olfr576; Or51a7", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-5676385-5677371; olfactory receptor 576, pseudogene 1; olfactory receptor 576; olfactory receptor MOR8-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258248)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071396 cellular response to lipid;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JFH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20491-1", "uniprot_id": [ { "id": "FCERG_MOUSE", "url": "https://www.uniprot.org/uniprot/P20491", "type": "external" } ], "mass": 9652.0, "length": 86, "protein_name": "High affinity immunoglobulin epsilon receptor subunit gamma", "gene_name": "Fcer1g", "organism": "Mouse", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit gamma precursor", "refseq_ac": [ { "id": "NP_034315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034315", "type": "external" } ], "gene_names_uniprotkb": "Fcer1g; Fce1g", "gene_names_refseq": "CD23; FcR-gamma; FcR[g]; FcRgamma; Fce1g; FcepsilonRI; Fcer1g; Ly-50", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit gamma; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FcRgamma; FceRI gamma; IgE Fc receptor subunit gamma", "protein_names_refseq": "Fc receptor gamma-chain; fc-epsilon RI-gamma; fceRI gamma; high affinity immunoglobulin epsilon receptor subunit gamma precursor; high affinity immunoglobulin epsilon receptor subunit gamma; igE Fc receptor subunit gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:14127); (R-MMU-114604); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5621480); (R-MMU-6798695); (R-MMU-75892)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "14764707;17050534;17086186;17947660;18776906;19098920;19144319;20817736;21750661;23602766;2527850;25428506;26495903;9171347", "class_list": "", "function": "Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells (PubMed:14764707). As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset (PubMed:19098920). Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (Probable) (PubMed:23602766). May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation (PubMed:17086186). Also involved in integrin alpha-2/ITGA2-mediated platelet activation (PubMed:9171347)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0032998 Fc-epsilon receptor I complex", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0030316 osteoclast differentiation;GO:0002283 neutrophil activation involved in immune response;GO:0002431 Fc receptor mediated stimulatory signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P20491-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVH9-1", "uniprot_id": [ { "id": "FBLN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVH9", "type": "external" } ], "mass": 50193.0, "length": 448, "protein_name": "Fibulin-5", "gene_name": "Fbln5", "organism": "Mouse", "refseq_name": "fibulin-5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_035942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035942", "type": "external" } ], "gene_names_uniprotkb": "Fbln5; Dance", "gene_names_refseq": "A55; DANCE; EVEC; Fbln5", "protein_names_uniprotkb": "Fibulin-5; Dance; Developmental arteries and neural crest EGF-like protein; FIBL-5", "protein_names_refseq": "FIBL-5; developmental arteries and neural crest EGF-like protein; fibulin-5 isoform 2 precursor", "tax_id": 10090, "disease": "autosomal recessive cutis laxa type IA (Disease Ontology:DOID:0070135); autosomal dominant cutis laxa 2 (Disease Ontology:DOID:0070136); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); age related macular degeneration (Disease Ontology:DOID:10871); cutis laxa (Disease Ontology:DOID:3144)", "pathway": " (mmu:23876); (R-MMU-1566948); (R-MMU-2129379)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10428823;11805834;11805835;12021267;14745449;21750661;26495903;28011936;30899004;35171214;40997131", "class_list": "", "function": "Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice., [RefSeq, PubMed]; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:11805835). May act as an adapter that mediates the interaction between FBN1 and ELN (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; FBLN-5 is a novel TGF-beta-inducible target gene that regulates cell growth and motility in a context-specific manner and affects protein kinase activation by TGF-beta., [RefSeq, PubMed]; Fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibres in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q541Z7", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033690 positive regulation of osteoblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9WVH9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VIS4-1", "uniprot_id": [ { "id": "FILA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2VIS4", "type": "external" } ], "mass": 251372.0, "length": 2362, "protein_name": "Filaggrin-2", "gene_name": "Flg2", "organism": "Mouse", "refseq_name": "filaggrin-2", "refseq_ac": [ { "id": "NP_001013826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013826", "type": "external" } ], "gene_names_uniprotkb": "Flg2", "gene_names_refseq": "EG229574; Flg2", "protein_names_uniprotkb": "Filaggrin-2; FLG-2; Intermediate filament-associated protein", "protein_names_refseq": "filaggrin-2; intermediate filament-associated protein", "tax_id": 10090, "disease": "peeling skin syndrome 6 (Disease Ontology:DOID:0070525)", "pathway": " (mmu:229574); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22417302;22645316", "class_list": "", "function": "Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis., [UniProtKB, UniProtKB]; In metabolically (essential fatty acid-deficient diet) induced skin barrier dysfunction, filaggrin-2 expression was significantly reduced, whereas filaggrin expression was up-regulated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8CB36", "ec_number_list": [], "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope;GO:0036457 keratohyalin granule", "go_biological_process": "GO:0007155 cell adhesion;GO:0061436 establishment of skin barrier;GO:0048730 epidermis morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q2VIS4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4V4-1", "uniprot_id": [ { "id": "FBXL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4V4", "type": "external" } ], "mass": 48682.0, "length": 428, "protein_name": "F-box/LRR-repeat protein 3", "gene_name": "Fbxl3", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 3 isoform 1", "refseq_ac": [ { "id": "NP_056637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056637", "type": "external" } ], "gene_names_uniprotkb": "Fbxl3; Afh; Fbl3a; Fbxl3a; Ovtm", "gene_names_refseq": "FBK; Fbl3a; Fbxl3a; Fbxl3; Ovtm; Play68", "protein_names_uniprotkb": "F-box/LRR-repeat protein 3; F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A; Protein after-hours; Protein overtime", "protein_names_refseq": "F-box and leucine-rich repeat protein 3a; F-box/LRR-repeat protein 3 isoform 1; F-box/LRR-repeat protein 3A; F-box/LRR-repeat protein 3; protein after-hours; protein overtime", "tax_id": 10090, "disease": "", "pathway": " (mmu:50789); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10531037;17462724;17463252;18953409;21750661;23452855;23452856;23616524;26776516;29937374;30500822;34428180;36210013", "class_list": "", "function": "Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80V32;Q8K1W0;Q9QXW1", "ec_number_list": [], "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process;GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C4V4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER69-1", "uniprot_id": [ { "id": "FL2D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER69", "type": "external" } ], "mass": 44177.0, "length": 396, "protein_name": "Pre-mRNA-splicing regulator WTAP", "gene_name": "Wtap", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing regulator WTAP isoform b", "refseq_ac": [ { "id": "NP_001107004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107004", "type": "external" } ], "gene_names_uniprotkb": "Wtap", "gene_names_refseq": "2810408K05Rik; 9430038B09Rik; Wtap", "protein_names_uniprotkb": "Pre-mRNA-splicing regulator WTAP; Female-lethal(2)D homolog; WT1-associated protein; Wilms tumor 1-associating protein", "protein_names_refseq": "WT1-associated protein; Wilms tumour 1-associating protein; Wilms' tumour 1-associating protein; female-lethal(2)D homolog; pre-mRNA-splicing regulator WTAP isoform b; pre-mRNA-splicing regulator WTAP; wilms tumor 1-associating protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:60532); (R-MMU-72203)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11001926;12522145;17088532;21183079;21750661;29535189;29547716;34887587", "class_list": "", "function": "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U120;Q566J5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9ER69-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X9C2-1", "uniprot_id": [ { "id": "FBX50_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X9C2", "type": "external" } ], "mass": 30408.0, "length": 266, "protein_name": "F-box only protein 50", "gene_name": "Nccrp1", "organism": "Mouse", "refseq_name": "F-box only protein 50", "refseq_ac": [ { "id": "NP_001074584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074584", "type": "external" } ], "gene_names_uniprotkb": "Nccrp1; Fbxo50", "gene_names_refseq": "1190020J12Rik; Gm163; NCCRP-1; Nccrp1", "protein_names_uniprotkb": "F-box only protein 50; NCC receptor protein 1; NCCRP-1; Non-specific cytotoxic cell receptor protein 1 homolog", "protein_names_refseq": "F-box only protein 50; NCC receptor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233038)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;22087255;31219806;34428180", "class_list": "", "function": "Promotes cell proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT24", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3X9C2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWW9-1", "uniprot_id": [ { "id": "FND3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NWW9", "type": "external" } ], "mass": 132764.0, "length": 1207, "protein_name": "Fibronectin type III domain-containing protein 3B", "gene_name": "Fndc3b", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 3B", "refseq_ac": [ { "id": "NP_775274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775274", "type": "external" } ], "gene_names_uniprotkb": "Fndc3b; Fad104; Kiaa4164; Ns5abp37", "gene_names_refseq": "1600019O04Rik; Fad104; Fndc3b; mKIAA4164", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 3B; Factor for adipocyte differentiation 104; HCV NS5A-binding protein 37", "protein_names_refseq": "HCV NS5A-binding protein 37; factor for adipocyte differentiation 104; fibronectin type III domain-containing protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72007)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "16904100;17242355;19138685;20493170;21183079;21750661;25428506;25428507;26948083;27521659;30084848;30779550;31219806;31541092;33649389;34428180;36336231;37507081;37828378;40997131", "class_list": "", "function": "FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease., [RefSeq, PubMed]; Fad104 is essential for the survival of newborns just after birth and important for cell proliferation, adhesion, spreading and migration., [RefSeq, PubMed]; Fad104 reciprocally regulates differentiation of adipocytes and osteoblast; functions as a positive regulator in adipocyte differentiation and as a negative regulator in osteoblast differentiation., [RefSeq, PubMed]; Fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity, [RefSeq, PubMed]; Findings highlight a physiological role for circRNAs in cardiac repair and indicate that modulation of circFndc3b expression may represent a potential strategy to promote cardiac function and remodeling after MI. Erratum:[Nat Commun. 2020 May 1;11(1):2234. doi: 10.1038/s41467-020-15382-x. PMID: 32358483] Publication Status: Online-Only, [RefSeq, PubMed]; May be positive regulator of adipogenesis., [UniProtKB]; MiR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWZ2;Q570Z2;Q80YF7;Q8BLH9;Q8CH86", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0016477 cell migration;GO:0045600 positive regulation of fat cell differentiation;GO:0034446 substrate adhesion-dependent cell spreading;GO:0048146 positive regulation of fibroblast proliferation;GO:0060510 type II pneumocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6NWW9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62446-1", "uniprot_id": [ { "id": "FKBP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62446", "type": "external" } ], "mass": 25148.0, "length": 224, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP3", "gene_name": "Fkbp3", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP3", "refseq_ac": [ { "id": "NP_038930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038930", "type": "external" } ], "gene_names_uniprotkb": "Fkbp3; Fkbp25", "gene_names_refseq": "25kDa; FKBP-3; FKBP25; Fkbp3", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; 5.2.1.8; FK506-binding protein 3; FKBP-25; FKBP-3; Immunophilin FKBP25; PPIase FKBP3; Rapamycin-selective 25 kDa immunophilin; Rotamase", "protein_names_refseq": "25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; PPIase FKBP3; immunophilin FKBP25; peptidyl-prolyl cis-trans isomerase FKBP3; rapamycin-selective 25 kDa immunophilin; rotamase", "tax_id": 10090, "disease": "", "pathway": " (mmu:30795)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;23806337;29969783;31219806;33553183;34428180;36288343;37345229;8956998", "class_list": "", "function": "FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity)., [UniProtKB]; FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation., [RefSeq, PubMed]; Findings reveal that the nuclear import of FKBP25 and binding with 60S ribosomal protein L7a are protective stress responses to ischemia/nitrosaive stress injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTJ7", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62446-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RT62-1", "uniprot_id": [ { "id": "FXL16_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RT62", "type": "external" } ], "mass": 51878.0, "length": 479, "protein_name": "F-box/LRR-repeat protein 16", "gene_name": "Fbxl16", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 16 isoform 1", "refseq_ac": [ { "id": "NP_001157697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697", "type": "external" } ], "gene_names_uniprotkb": "Fbxl16", "gene_names_refseq": "Fbxl16; Scirr1", "protein_names_uniprotkb": "F-box/LRR-repeat protein 16; F-box and leucine-rich repeat protein 16", "protein_names_refseq": "F-box/LRR-repeat protein 16 isoform 1; F-box/LRR-repeat protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:214931); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17603280;21750661;24129315;24390425;31219806;33300544", "class_list": "", "function": "FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells., [RefSeq, PubMed]; SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2RT62-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23188-1", "uniprot_id": [ { "id": "FURIN_MOUSE", "url": "https://www.uniprot.org/uniprot/P23188", "type": "external" } ], "mass": 86772.0, "length": 793, "protein_name": "Furin", "gene_name": "Furin", "organism": "Mouse", "refseq_name": "furin preproprotein", "refseq_ac": [ { "id": "NP_001074923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074923", "type": "external" } ], "gene_names_uniprotkb": "Furin; Fur; Pcsk3", "gene_names_refseq": "9130404I01Rik; Furin; Fur; PACE; Pcsk3; SPC1", "protein_names_uniprotkb": "Furin; 3.4.21.75; Dibasic-processing enzyme; PACE; Paired basic amino acid residue-cleaving enzyme; Prohormone convertase 3", "protein_names_refseq": "dibasic-processing enzyme; furin preproprotein; paired basic amino acid residue cleaving enzyme; prohormone convertase 3; proprotein convertase subtilisin/kexin type 3; subtilisin pro-protein processing enzyme", "tax_id": 10090, "disease": "arteriosclerosis (Disease Ontology:DOID:2349); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18550); (R-MMU-1442490); (R-MMU-1566948); (R-MMU-1592389); (R-MMU-159782); (R-MMU-167060); (R-MMU-186797); (R-MMU-1912420); (R-MMU-2173789); (R-MMU-2173796); (R-MMU-8963889); (R-MMU-9768727); (R-MMU-9953170)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "12794637;18713856;21750661;2266110;34428180;37828378;38002338;39212413;39337476;9412467", "class_list": "", "function": "Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing., [RefSeq, PubMed]; The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:18713856). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45) (By similarity). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (PubMed:18713856)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTN6", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.94", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" }, { "id": "3.4.21.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.93", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0012510 trans-Golgi network transport vesicle membrane;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032902 nerve growth factor production;GO:0090472 dibasic protein processing;GO:0097341 zymogen inhibition;GO:0016485 protein processing;GO:0016486 peptide hormone processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P23188-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30416-1", "uniprot_id": [ { "id": "FKBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P30416", "type": "external" } ], "mass": 51572.0, "length": 458, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP4", "gene_name": "Fkbp4", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP4", "refseq_ac": [ { "id": "NP_034349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034349", "type": "external" } ], "gene_names_uniprotkb": "Fkbp4; Fkpb52", "gene_names_refseq": "FKBP-4; FKBP-52; FKBP52; FKPB52; Fkbp4; p59", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP4; 5.2.1.8; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506-binding protein 4; FKBP-4; FKBP-52; FKBP59; HBI; HSP-binding immunophilin; Immunophilin FKBP52; PPIase FKBP4; Rotamase; p59", "protein_names_refseq": "52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FKBP59; HBI; HSP-binding immunophilin; PPIase FKBP4; immunophilin FKBP52; peptidyl-prolyl cis-trans isomerase FKBP4; rotamase", "tax_id": 10090, "disease": "androgen insensitivity syndrome (Disease Ontology:DOID:4674)", "pathway": " (mmu:14228); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-8939211); (R-MMU-9018519)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "11278753;11751894;21540332;21750661;22645316;22872234;24129315;25153642;25605945;26495903;27418439;28135057;28528544;34072036;34428180;34887587;35984892;37248902;37507081;7693550;8341706;9195923", "class_list": "", "function": "Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies., [RefSeq, PubMed]; Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria., [UniProtKB, PubMed, PubMed, PubMed]; Study demonstrates that FKBP52 by itself does not directly affect cognition and may play an indirect, modulatory role in the functional pathology of Alzheimer's disease, whereas it directly affects motor coordination, an early sign of neurodegenerative damages to the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVC9", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0031072 heat shock protein binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0031111 negative regulation of microtubule polymerization or depolymerization;GO:0046661 male sex differentiation;GO:0006463 steroid hormone receptor complex assembly;GO:0010977 negative regulation of neuron projection development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P30416-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35615-1", "uniprot_id": [ { "id": "FOG1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35615", "type": "external" } ], "mass": 105984.0, "length": 995, "protein_name": "Zinc finger protein ZFPM1", "gene_name": "Zfpm1", "organism": "Mouse", "refseq_name": "zinc finger protein ZFPM1", "refseq_ac": [ { "id": "NP_033595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033595", "type": "external" } ], "gene_names_uniprotkb": "Zfpm1; Fog1; Fog", "gene_names_refseq": "FOG; Fog1; Zfpm1", "protein_names_uniprotkb": "Zinc finger protein ZFPM1; FOG-1; Friend of GATA 1; Friend of GATA protein 1; Zinc finger protein multitype 1", "protein_names_refseq": "FOG-1; Friend of GATA 1; friend of GATA protein 1; zinc finger protein ZFPM1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22761); (R-MMU-8936459); (R-MMU-983231)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10078204;10329627;11940669;12356738;14614148;15234987;17242355;21183079;25428506;25605945;30084848;30779550;33046550;34428180;9230307;9553047;9837943", "class_list": "", "function": "Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior., [RefSeq, PubMed]; Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 45, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0030851 granulocyte differentiation;GO:0003192 mitral valve formation;GO:0003195 tricuspid valve formation;GO:0010724 regulation of definitive erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35615-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97872-1", "uniprot_id": [ { "id": "FMO5_MOUSE", "url": "https://www.uniprot.org/uniprot/P97872", "type": "external" } ], "mass": 60001.0, "length": 533, "protein_name": "Flavin-containing monooxygenase 5", "gene_name": "Fmo5", "organism": "Mouse", "refseq_name": "flavin-containing monooxygenase 5 isoform 1", "refseq_ac": [ { "id": "NP_001155235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155235", "type": "external" } ], "gene_names_uniprotkb": "Fmo5", "gene_names_refseq": "5033418D19Rik; Fmo5", "protein_names_uniprotkb": "Flavin-containing monooxygenase 5; 1.14.13.8; 1.6.3.1; Dimethylaniline monooxygenase [N-oxide-forming] 5; Dimethylaniline oxidase 5; FMO 5; Hepatic flavin-containing monooxygenase 5; NADPH oxidase", "protein_names_refseq": "NADPH oxidase; NAPDH oxidase; dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline oxidase 5; flavin-containing monooxygenase 5 isoform 1; hepatic flavin-containing monooxygenase 5", "tax_id": 10090, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (mmu:14263)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17721934;21183079;25428506;26049045;26495903;28011936;28646079;29686991;34428180;37267233;37453647;9580872", "class_list": "", "function": "Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (PubMed:26049045, PubMed:28646079)., [UniProtKB, UniProtKB, PubMed, PubMed]; Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; The functional activity of Fmo5 was determined., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1W6", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0050661 NADP binding;GO:0004497 monooxygenase activity;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0090181 regulation of cholesterol metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P97872-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9Q6-1", "uniprot_id": [ { "id": "FKB15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9Q6", "type": "external" } ], "mass": 132961.0, "length": 1216, "protein_name": "FK506-binding protein 15", "gene_name": "Fkbp15", "organism": "Mouse", "refseq_name": "FK506-binding protein 15 isoform 1", "refseq_ac": [ { "id": "NP_001038993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038993", "type": "external" } ], "gene_names_uniprotkb": "Fkbp15; Fkbp133; Kiaa0674", "gene_names_refseq": "C430014M02Rik; FKBO133; FKBP-133; FKBP-15; FKBP133; Fkbp15; mKIAA0674", "protein_names_uniprotkb": "FK506-binding protein 15; 133 kDa FK506-binding protein; 133 kDa FKBP; FKBP-133; FKBP-15; WAFL; WASP and FKBP-like", "protein_names_refseq": "133 kDa FK506-binding protein; 133 kDa FKBP; FK506-binding protein 133; FK506-binding protein 15 isoform 1; WAFL", "tax_id": 10090, "disease": "", "pathway": " (mmu:338355)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16756961;17242355;19144319;21183079;21750661;26495903;29084197;32848054;39627609;40885482", "class_list": "", "function": "FKBP133 contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) and a domain homologous to FK506-binding protein motif., [RefSeq, PubMed]; Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement (By similarity). May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSY4;Q5SQG3;Q80TU5", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6P9Q6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIA4-1", "uniprot_id": [ { "id": "FBXW8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIA4", "type": "external" } ], "mass": 67956.0, "length": 598, "protein_name": "F-box/WD repeat-containing protein 8", "gene_name": "Fbxw8", "organism": "Mouse", "refseq_name": "F-box/WD repeat-containing protein 8", "refseq_ac": [ { "id": "NP_766309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766309", "type": "external" } ], "gene_names_uniprotkb": "Fbxw8", "gene_names_refseq": "4930438M06Rik; FBW6; FBW8; FBXO29; Fbx29; Fbxw8", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8", "protein_names_refseq": "F-box and WD-40 domain-containing protein 8; F-box protein FBX29; F-box/WD repeat-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:231672); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16880526;17205132;17242355;17998335;21183079;22124152;23142081;29153991;31219806;34428180", "class_list": "", "function": "Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8., [RefSeq, PubMed]; Depletion of FBXW8 caused a significant accumulation of cyclin D1, as well as sequestration of CDK1 in the cytoplasm. This resulted in a severe reduction of cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (By similarity). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:23142081). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (By similarity). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition (PubMed:22124152). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BI62;Q8BI75;Q8BI76;Q8CID8;Q921Z1", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0008283 cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060271 cilium assembly;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BIA4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX90-1", "uniprot_id": [ { "id": "FND3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX90", "type": "external" } ], "mass": 131958.0, "length": 1198, "protein_name": "Fibronectin type-III domain-containing protein 3A", "gene_name": "Fndc3a", "organism": "Mouse", "refseq_name": "fibronectin type-III domain-containing protein 3A", "refseq_ac": [ { "id": "NP_997519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997519", "type": "external" } ], "gene_names_uniprotkb": "Fndc3a; D14Ertd453e; Fndc3; Kiaa0970", "gene_names_refseq": "1700094E19Rik; D14Ertd453e; F730017H24Rik; Fndc3a; Fndc3; sys", "protein_names_uniprotkb": "Fibronectin type-III domain-containing protein 3A", "protein_names_refseq": "fibronectin domain-containing protein 3a; fibronectin type-III domain-containing protein 3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:319448)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16904100;17242355;21183079;21750661;22872234;23806337;30084848;30779550;31219806;34428180", "class_list": "", "function": "Mediates spermatid-Sertoli adhesion during spermatogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Models are presented for the function of FNDC3A in mediating spermatid-Sertoli adhesion during mouse spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2VEY7;Q3T9K5;Q6ZQ15;Q811D3;Q8BME4;Q8BTM3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0098609 cell-cell adhesion;GO:0060009 Sertoli cell development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BX90-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0V9-1", "uniprot_id": [ { "id": "FRMD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0V9", "type": "external" } ], "mass": 71652.0, "length": 622, "protein_name": "FERM domain-containing protein 6", "gene_name": "Frmd6", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 6 isoform 2", "refseq_ac": [ { "id": "NP_082403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082403", "type": "external" } ], "gene_names_uniprotkb": "Frmd6", "gene_names_refseq": "2610019M19Rik; 4930488L10Rik; Frmd6; Willin", "protein_names_uniprotkb": "FERM domain-containing protein 6", "protein_names_refseq": "FERM domain-containing protein 6 isoform 2; FERM domain-containing protein 6", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:319710)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15345747;17242355;21183079;21685893;22512338;23593160;25428506;30084848;30667167;31219806;32024965;34428180;36210013", "class_list": "", "function": "Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury. Publication Status: Online-Only, [RefSeq, PubMed]; Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that the nectin-afadin interaction plays a role in the correct localization of Willin, [RefSeq, PubMed]; The aged CMECs utilize BDNF-TrkB-T1 signalling to recruit Willin as a downstream effector to further activate the Hippo pathway, which then promotes migration., [RefSeq, PubMed]; Willin is predominantly expressed in fibroblasts and that Willin expression activates the Hippo signaling cascade Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW34", "ec_number_list": [], "go_molecular_function": "GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0043296 apical junction complex", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0032970 regulation of actin filament-based process;GO:0035332 positive regulation of hippo signaling;GO:0003383 apical constriction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C0V9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20029-1", "uniprot_id": [ { "id": "BIP_MOUSE", "url": "https://www.uniprot.org/uniprot/P20029", "type": "external" } ], "mass": 72422.0, "length": 655, "protein_name": "Endoplasmic reticulum chaperone BiP", "gene_name": "Hspa5", "organism": "Mouse", "refseq_name": "endoplasmic reticulum chaperone BiP precursor", "refseq_ac": [ { "id": "NP_001156906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156906", "type": "external" } ], "gene_names_uniprotkb": "Hspa5; Grp78", "gene_names_refseq": "Bip; D2Wsu141e; D2Wsu17e; Grp78; Hsce70; Hspa5; SEZ-7; Sez7; baffled; mBiP", "protein_names_uniprotkb": "Endoplasmic reticulum chaperone BiP; 3.6.4.10; 78 kDa glucose-regulated protein; BiP; Binding-immunoglobulin protein; GRP-78; HSP70 family protein 5; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein", "protein_names_refseq": "78 kDa glucose-regulated protein; GRP-78; HSP70 family protein 5; XAP-1 antigen; binding-immunoglobulin protein; endoplasmic reticulum chaperone BiP precursor; endoplasmic reticulum chaperone BiP; glucose regulated protein, 78 kDa; heat shock 70 kDa protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock protein 5; heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); ureteral obstruction (Disease Ontology:DOID:5199); rheumatoid arthritis (Disease Ontology:DOID:7148); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:14828); (R-MMU-3371453); (R-MMU-983170)", "pathway_count": 3, "publication_count": 50, "publication_id_list": "10854322;11465105;11836248;12065409;12411443;12475965;12648094;16075062;16800626;16931514;17242355;17322886;19144319;20173027;20484814;20945367;21183079;21750661;21992152;23806337;23921388;25009997;25428506;2559088;25605945;2583523;26495903;27159390;28011936;2895472;30059200;31219806;32152506;33300544;33863978;34428180;34887587;35984892;36288343;37453647;37507081;37828378;39627609;39927985;40684658;40885482;7522249;7523108;7607546;8645260", "class_list": "", "function": "Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:10854322). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:10854322). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:10854322). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35642;Q3UFF2;Q61630", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:0010976 positive regulation of neuron projection development;GO:0030335 positive regulation of cell migration;GO:0036498 IRE1-mediated unfolded protein response;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P20029-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27600-1", "uniprot_id": [ { "id": "GNA12_MOUSE", "url": "https://www.uniprot.org/uniprot/P27600", "type": "external" } ], "mass": 44095.0, "length": 379, "protein_name": "Guanine nucleotide-binding protein subunit alpha-12", "gene_name": "Gna12", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein subunit alpha-12", "refseq_ac": [ { "id": "NP_034432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432", "type": "external" } ], "gene_names_uniprotkb": "Gna12; Gna-12", "gene_names_refseq": "Galpha12; Gna12", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-12; G alpha-12; G protein subunit alpha-12", "protein_names_refseq": "G-protein subunit alpha-12; g alpha-12; guanine nucleotide-binding protein subunit alpha-12", "tax_id": 10090, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14673); (R-MMU-416482); (R-MMU-456926)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "15240885;16388592;1905812;19151758;21212405;21750661;22609986;22645316;2508088;30084848;31219806;34203471;34428180;36210013;37225434;38491049;9485474", "class_list": "", "function": "Galpha12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:19151758, PubMed:21212405, PubMed:22609986). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). Together with NAPA promotes CDH5 localization to plasma membrane (By similarity). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031752 D5 dopamine receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P27600-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61115-1", "uniprot_id": [ { "id": "PTC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61115", "type": "external" } ], "mass": 159273.0, "length": 1434, "protein_name": "Protein patched homolog 1", "gene_name": "Ptch1", "organism": "Mouse", "refseq_name": "protein patched homolog 1 isoform a", "refseq_ac": [ { "id": "NP_032983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032983", "type": "external" } ], "gene_names_uniprotkb": "Ptch1; Ptch", "gene_names_refseq": "A230106A15Rik; Ptc1; Ptch1; Ptch; Ptc; mes; wig", "protein_names_uniprotkb": "Protein patched homolog 1; PTC1; PTC", "protein_names_refseq": "Ptch1 protein +12b; mesenchymal dysplasia; protein patched homolog 1 isoform a; protein patched homolog 1", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); medulloblastoma (Disease Ontology:DOID:0050902); nevoid basal cell carcinoma syndrome 1 (Disease Ontology:DOID:0070365); spina bifida (Disease Ontology:DOID:0080016); holoprosencephaly 7 (Disease Ontology:DOID:0110876); nasopharyngitis (Disease Ontology:DOID:10460); stomach cancer (Disease Ontology:DOID:10534); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); holoprosencephaly (Disease Ontology:DOID:4621); gallbladder carcinoma (Disease Ontology:DOID:4948); basaloid squamous cell carcinoma (Disease Ontology:DOID:5522); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19206); (R-MMU-5610787); (R-MMU-5632681); (R-MMU-5632684); (R-MMU-5635838)", "pathway_count": 5, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;12192414;17641202;19892989;21183079;21537345;21750661;21931618;21952136;24062445;24925320;25092867;25428506;25605945;27552050;27802388;28344083;30084848;30415841;30779550;30819883;31657721;33139559;34174188;34428180;34698632;35658032;35820727;8595881;9262482", "class_list": "", "function": "Negative regulator of the smoothened signaling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens (PubMed:12192414, PubMed:17641202, PubMed:21537345, PubMed:21931618, PubMed:27552050, PubMed:30415841, PubMed:33139559, PubMed:9262482). In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO (PubMed:30415841, PubMed:31657721, PubMed:34698632). Hedgehog-binding inhibits PTCH1 cholesterol transporter activity, promoting SMO activation by cholesterol and transduction of the smoothened signaling pathway (PubMed:30819883). Molecular mechanism governing cholesterol transport are still unclear: may move cholesterol from the outer to the inner leaflet of the membrane in exchange for potassium or sodium ion export in the opposite direction (PubMed:30415841, PubMed:34698632)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 21, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0015485 cholesterol binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0045177 apical part of cell", "go_biological_process": "GO:0043279 response to alkaloid;GO:0060603 mammary gland duct morphogenesis;GO:0010157 response to chlorate;GO:0061005 cell differentiation involved in kidney development;GO:0072203 cell proliferation involved in metanephros development", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q61115-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62196-1", "uniprot_id": [ { "id": "PRS8_MOUSE", "url": "https://www.uniprot.org/uniprot/P62196", "type": "external" } ], "mass": 45626.0, "length": 406, "protein_name": "26S proteasome regulatory subunit 8", "gene_name": "Psmc5", "organism": "Mouse", "refseq_name": "26S proteasome regulatory subunit 8", "refseq_ac": [ { "id": "NP_032976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032976", "type": "external" } ], "gene_names_uniprotkb": "Psmc5; Sug1", "gene_names_refseq": "Psmc5; Rpt6; mSUG1", "protein_names_uniprotkb": "26S proteasome regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; mSUG1; p45/SUG", "protein_names_refseq": "26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; 26S proteasome regulatory subunit 8; p45/SUG; proteasome 26S subunit ATPase 5; proteasome subunit p45", "tax_id": 10090, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:19184); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 56, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16857966;17349974;20112406;22645316;31219806;33658307;34203471;34428180;35820727;37453647;37828378;38001534;8598193", "class_list": "", "function": "Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]; PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35051;P47210;P52915;P52916;Q3UL51;Q9CWN5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0140296 general transcription initiation factor binding", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0031595 nuclear proteasome complex;GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0090261 positive regulation of inclusion body assembly;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P62196-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61553-1", "uniprot_id": [ { "id": "FSCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61553", "type": "external" } ], "mass": 54508.0, "length": 493, "protein_name": "Fascin", "gene_name": "Fscn1", "organism": "Mouse", "refseq_name": "fascin", "refseq_ac": [ { "id": "NP_032010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032010", "type": "external" } ], "gene_names_uniprotkb": "Fscn1; Fan1; Snl", "gene_names_refseq": "Fan1; Fscn1; fascin-1", "protein_names_uniprotkb": "Fascin; Singed-like protein", "protein_names_refseq": "fascin 1; fascin; singed-like protein", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:14086)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;16966425;20393565;21685497;21706053;21750661;22155786;23806337;24720729;25428506;28135057;28528544;28855604;33300544;35820727;38449390;38600569;39627609;40684658;7738015;8794867", "class_list": "", "function": "Actin-binding protein that contains 2 major actin binding sites (By similarity). Organizes filamentous actin into parallel bundles (PubMed:7738015). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (By similarity). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:21685497). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF., [UniProtKB, UniProtKB, UniProtKB]; Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. Publication Status: Online-Only, [RefSeq, PubMed]; SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O09099;O09156;Q05DK3;Q7TN32;Q80V75", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0044393 microspike;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0035089 establishment of apical/basal cell polarity;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q61553-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C042-1", "uniprot_id": [ { "id": "ENO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C042", "type": "external" } ], "mass": 67853.0, "length": 619, "protein_name": "Enolase 4", "gene_name": "Eno4", "organism": "Mouse", "refseq_name": "enolase 4", "refseq_ac": [ { "id": "NP_848804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848804", "type": "external" } ], "gene_names_uniprotkb": "Eno4", "gene_names_refseq": "6430537H07Rik; Eno4", "protein_names_uniprotkb": "Enolase 4; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; enolase 4; enolase-like protein C10orf134 homolog; enolase-like protein ENO4", "tax_id": 10090, "disease": "", "pathway": " (mmu:226265); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;23446454;32248064", "class_list": "", "function": "ENO4 is required for normal assembly of the fibrous sheath and provides most of the enolase activity in sperm. Publication Status: Online-Only, [RefSeq, PubMed]; Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (Probable). Required for sperm motility, function and male fertility. May be involved in the normal assembly of the sperm fibrous sheath and provides most of the enolase activity in sperm (PubMed:23446454)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLA7;Q8BVS9;Q8CFL9", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0097228 sperm principal piece;GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0006096 glycolytic process;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C042-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08460-1", "uniprot_id": [ { "id": "KCMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08460", "type": "external" } ], "mass": 134396.0, "length": 1209, "protein_name": "Calcium-activated potassium channel subunit alpha-1", "gene_name": "Kcnma1", "organism": "Mouse", "refseq_name": "calcium-activated potassium channel subunit alpha-1 isoform 9", "refseq_ac": [ { "id": "NP_001240294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240294", "type": "external" } ], "gene_names_uniprotkb": "Kcnma1; Kcnma", "gene_names_refseq": "5730414M22Rik; BKCA alpha; BKCa; KCa1.1; Kcnma1; MaxiK; Slo1; Slo; k(VCA)alpha; mSlo1; mSlo; slo-alpha", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; mSlo1; mSlo", "protein_names_refseq": "BK channel alpha subunit; calcium-activated potassium channel subunit alpha-1 isoform 9; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; maxi K channel; slo homolog; slowpoke homolog", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); paroxysmal nonkinesigenic dyskinesia 3 (Disease Ontology:DOID:0070442); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); alcohol use disorder (Disease Ontology:DOID:1574); generalized epilepsy (Disease Ontology:DOID:1827); substance-related disorder (Disease Ontology:DOID:303)", "pathway": " (mmu:16531); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10517674;10804197;11112549;12149279;12192410;12192411;12388098;16341213;21183079;21750661;22935415;30084848;33300544;34418053;34428180;35820727;36210013;38779757;38945286;39927985;7687074;7987297", "class_list": "", "function": "Involvement of ObRb receptor, nitric oxide, and BKCa channel signaling pathways in leptin-induced relaxation of pregnant mouse uterus., [RefSeq, PubMed]; Kcnma1 alternative splicing in mouse kidney: regulation during development and by dietary K[+] intake., [RefSeq, PubMed]; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q64703;Q8VHF1;Q9R196", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0034465 response to carbon monoxide;GO:0006970 response to osmotic stress;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q08460-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQY0-1", "uniprot_id": [ { "id": "ERN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQY0", "type": "external" } ], "mass": 110185.0, "length": 977, "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "gene_name": "Ern1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase/endoribonuclease IRE1 precursor", "refseq_ac": [ { "id": "NP_076402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076402", "type": "external" } ], "gene_names_uniprotkb": "Ern1; Ire1", "gene_names_refseq": "9030414B18Rik; Ern1; Ire1alpha; Ire1a; Ire1p", "protein_names_uniprotkb": "Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; IRE1a; Inositol-requiring protein 1; Ire1-alpha", "protein_names_refseq": "endoplasmic reticulum (ER) to nucleus signalling 1; endoplasmic reticulum-to-nucleus signaling 1; inositol-requiring 1 alpha; inositol-requiring protein 1; ire1-alpha; serine/threonine-protein kinase/endoribonuclease IRE1 precursor; serine/threonine-protein kinase/endoribonuclease IRE1", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); oropharynx cancer (Disease Ontology:DOID:8557)", "pathway": " (mmu:78943); (R-MMU-381070)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11146108;11780124;11850408;18281285;21750661;21911379;25164867;30118681;32759820;33610548;34428180;35500653;35975910;36739529", "class_list": "", "function": "Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11850408, PubMed:25164867). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:25164867). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11850408, PubMed:25164867). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11850408, PubMed:25164867). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D340", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:1990604 IRE1-TRAF2-ASK1 complex;GO:1990630 IRE1-RACK1-PP2A complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:1901142 insulin metabolic process;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9EQY0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4H8-1", "uniprot_id": [ { "id": "CUL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4H8", "type": "external" } ], "mass": 86877.0, "length": 745, "protein_name": "Cullin-2", "gene_name": "Cul2", "organism": "Mouse", "refseq_name": "cullin-2", "refseq_ac": [ { "id": "NP_083678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083678", "type": "external" } ], "gene_names_uniprotkb": "Cul2", "gene_names_refseq": "1300003D18Rik; 4932411N15Rik; Cul2; mKIAA4106", "protein_names_uniprotkb": "Cullin-2; CUL-2", "protein_names_refseq": "CUL-2; cullin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71745); (R-MMU-1234176); (R-MMU-8951664); (R-MMU-983168); (R-MMU-9954709)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11967155;12149480;16479539;18299400;21750661;21952136;23806337;25428506;25428507;25605945;30084848;31219806;33590678;34203471;34428180;35978186;37507081", "class_list": "", "function": "Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:33590678, PubMed:35978186). CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUR8", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0030891 VCB complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030163 protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9D4H8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TZZ7-1", "uniprot_id": [ { "id": "ESYT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TZZ7", "type": "external" } ], "mass": 94139.0, "length": 845, "protein_name": "Extended synaptotagmin-2", "gene_name": "Esyt2", "organism": "Mouse", "refseq_name": "extended synaptotagmin-2", "refseq_ac": [ { "id": "NP_083007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083007", "type": "external" } ], "gene_names_uniprotkb": "Esyt2; D12Ertd551e; Fam62b", "gene_names_refseq": "2410017M09Rik; 4921504I16Rik; CHR2SYT; D12Ertd551e; Esyt2; Fam62b", "protein_names_uniprotkb": "Extended synaptotagmin-2; E-Syt2", "protein_names_refseq": "E-Syt2; chr2 synaptotagmin; extended synaptotagmin-2; family with sequence similarity 62 (C2 domain containing), member B; family with sequence similarity 62, member B", "tax_id": 10090, "disease": "", "pathway": " (mmu:52635); (R-MMU-9845576)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "17242355;18299400;18977228;19144319;19822543;21183079;21750661;21952136;25428506;25486202;25605945;26495903;30059200;30084848;30779550;31219806;31599954;34203471;34428180;35820727;36201719;36210013;37828378", "class_list": "", "function": "ChR2 expression had no discernable effect on the putative vasomotor neurons at rest, [RefSeq, PubMed]; Mouse with deletions are generated:esyt2(-/-)/esyt3(-/-) develop normally and are viable and fertile; esyt2(-/-)/esyt3(-/-) embryonic fibroblasts show reduced ability to migrate, are less resistant to stringent culture conditions and to oxidative stress., [RefSeq, PubMed]; Murine E-Syt2 was studied by small-angle X-ray scattering (SAXS) providing a three-dimensional image of a protein with three C2 domains., [RefSeq, PubMed]; Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli. Publication Status: Online-Only, [RefSeq, PubMed]; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex (By similarity). Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RSN5;Q9D5Y7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006897 endocytosis;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q3TZZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZX0-1", "uniprot_id": [ { "id": "ELP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZX0", "type": "external" } ], "mass": 62385.0, "length": 547, "protein_name": "Elongator complex protein 3", "gene_name": "Elp3", "organism": "Mouse", "refseq_name": "elongator complex protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001240741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240741", "type": "external" } ], "gene_names_uniprotkb": "Elp3", "gene_names_refseq": "2610507P14Rik; Elp3; KAT9", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; tRNA uridine(34) acetyltransferase", "protein_names_refseq": "elongation protein 3 homolog; elongator complex protein 3 isoform 1; elongator complex protein 3; protein lysine acetyltransferase ELP3; tRNA uridine(34) acetyltransferase", "tax_id": 10090, "disease": "familial dysautonomia (Disease Ontology:DOID:11589)", "pathway": " (mmu:74195)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19185337;21183079;21750661;22153374;22854966;27476491;28507509;29415125;30084848;31219806;37640114", "class_list": "", "function": "Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis., [RefSeq, PubMed]; Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (By similarity). Not a major acetyltransferase of tubulin (PubMed:22153374). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (PubMed:28507509)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2K2;Q8R369", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008607 phosphorylase kinase regulator activity;GO:0000049 tRNA binding;GO:0016407 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030335 positive regulation of cell migration;GO:0001764 neuron migration;GO:0007417 central nervous system development;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CZX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70290-1", "uniprot_id": [ { "id": "EM55_MOUSE", "url": "https://www.uniprot.org/uniprot/P70290", "type": "external" } ], "mass": 52227.0, "length": 466, "protein_name": "55 kDa erythrocyte membrane protein", "gene_name": "Mpp1", "organism": "Mouse", "refseq_name": "55 kDa erythrocyte membrane protein", "refseq_ac": [ { "id": "NP_032647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032647", "type": "external" } ], "gene_names_uniprotkb": "Mpp1", "gene_names_refseq": "55kDa; C130070C03Rik; Mpp1; p55", "protein_names_uniprotkb": "55 kDa erythrocyte membrane protein; Membrane protein, palmitoylated 1; p55", "protein_names_refseq": "55 kDa erythrocyte membrane protein; erythrocyte protein p55; membrane protein, palmitoylated 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:17524)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "16829577;17242355;17584769;19144319;19897731;20661277;21183079;21750661;22645316;24788674;26495903;34428180;37507081;8954807", "class_list": "", "function": "Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Gelsolin was identified as the additional interacting partners to p55 in the whirlin interactome of hair cell stereocilia. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that p55 is required for neutrophil polarization by regulating Akt phosphorylation through a mechanism that is independent of PI3Kgamma activity., [RefSeq, PubMed]; This gene encodes a protein localized to the cell membrane. The protein serves as a scaffold for the assembly of the actin cytoskeleton, and plays a role in regulating apico-basal cell polarity. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0030863 cortical cytoskeleton;GO:0034451 centriolar satellite", "go_biological_process": "GO:0090022 regulation of neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70290-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQJ6-1", "uniprot_id": [ { "id": "DENR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQJ6", "type": "external" } ], "mass": 22166.0, "length": 198, "protein_name": "Density-regulated protein", "gene_name": "Denr", "organism": "Mouse", "refseq_name": "density-regulated protein isoform a", "refseq_ac": [ { "id": "NP_080879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080879", "type": "external" } ], "gene_names_uniprotkb": "Denr", "gene_names_refseq": "1500003K04Rik; Denr", "protein_names_uniprotkb": "Density-regulated protein; DRP", "protein_names_refseq": "DRP; density-regulated protein isoform a", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:68184)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;30982898;31219806;35984892", "class_list": "", "function": "Clock is a DENR target in mouse circadian timekeeping, [RefSeq, PubMed]; Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXY1", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0002188 translation reinitiation;GO:0032790 ribosome disassembly;GO:0075522 IRES-dependent viral translational initiation;GO:0001731 formation of translation preinitiation complex;GO:0002183 cytoplasmic translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50171-1", "uniprot_id": [ { "id": "DHB8_MOUSE", "url": "https://www.uniprot.org/uniprot/P50171", "type": "external" } ], "mass": 26588.0, "length": 259, "protein_name": "(3R)-3-hydroxyacyl-CoA dehydrogenase", "gene_name": "Hsd17b8", "organism": "Mouse", "refseq_name": "(3R)-3-hydroxyacyl-CoA dehydrogenase", "refseq_ac": [ { "id": "NP_038571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038571", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b8; H2-Ke6; Hke6", "gene_names_refseq": "D17H6S112E; H-2Ke6; H2-Ke6; Hsd17b8; Ke-6; Ke6; Ring2", "protein_names_uniprotkb": "(3R)-3-hydroxyacyl-CoA dehydrogenase; 1.1.1.239; 1.1.1.62; 1.1.1.n12; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; Estradiol 17-beta-dehydrogenase 8; KAR alpha subunit; Ke-6; Protein Ke6; Testosterone 17-beta-dehydrogenase 8", "protein_names_refseq": "(3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; H2-K region expressed gene 6; KAR alpha subunit; estradiol 17-beta-dehydrogenase 8; estrogen 17-oxidoreductase; testosterone 17-beta-dehydrogenase 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:14979); (R-MMU-75105)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15923359;16452087;21183079;21750661;23576753;23806337;34428180;37453647;37507081;7559658;8441417;9712896", "class_list": "", "function": "Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+)(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (By similarity). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. It efficiently catalyzes the oxidation of estradiol (E2), testosterone, and dihydrotestosterone. Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active estradiol (E2) (PubMed:9712896)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9K0;Q60958;Q60959;Q9Z1W2", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "4.2.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107", "type": "external" }, { "id": "4.2.1.119", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" } ], "go_molecular_function": "GO:0048038 quinone binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0070404 NADH binding;GO:0106386 (3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0051290 protein heterotetramerization;GO:0006703 estrogen biosynthetic process;GO:0008209 androgen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P50171-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J78-1", "uniprot_id": [ { "id": "DEFI8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J78", "type": "external" } ], "mass": 52311.0, "length": 448, "protein_name": "Differentially expressed in FDCP 8", "gene_name": "Def8", "organism": "Mouse", "refseq_name": "differentially expressed in FDCP 8 isoform 1", "refseq_ac": [ { "id": "NP_001240712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240712", "type": "external" } ], "gene_names_uniprotkb": "Def8; D8Ertd713e", "gene_names_refseq": "D8Ertd713e; DEF-8; Def8", "protein_names_uniprotkb": "Differentially expressed in FDCP 8; DEF-8", "protein_names_refseq": "differentially expressed in FDCP 8 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23854)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10460589;21183079;21750661;27777970", "class_list": "", "function": "Def8 was first identified in a retroviral gene-trap screen, [RefSeq, PubMed]; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Involved in bone resorption (PubMed:27777970)., [UniProtKB, PubMed]; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPT6;Q3UBE6;Q3UZ91;Q8BJN0;Q8BWP0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0045780 positive regulation of bone resorption;GO:0032418 lysosome localization;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99J78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PU8-1", "uniprot_id": [ { "id": "DHX30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PU8", "type": "external" } ], "mass": 136668.0, "length": 1217, "protein_name": "ATP-dependent RNA helicase DHX30", "gene_name": "Dhx30", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DHX30 isoform 1", "refseq_ac": [ { "id": "NP_001239611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239611", "type": "external" } ], "gene_names_uniprotkb": "Dhx30; Helg", "gene_names_refseq": "2810477H02Rik; C130058C04Rik; Ddx30; Dhx30; HELG; Ret-CoR", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX30; 3.6.4.13; DEAH box protein 30", "protein_names_refseq": "ATP-dependent RNA helicase DHX30 isoform 1; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DEAH box protein 30; putative ATP-dependent RNA helicase DHX30", "tax_id": 10090, "disease": "", "pathway": " (mmu:72831)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750661;22872234;25219788;31219806;34418053;34428180;34887587;38433184;39627609", "class_list": "", "function": "An improved gene trap method 'trapped' a helG gene expressed in mouse ES cells. The helG product shared a high level of homology with the DExH RNA helicase family. It is required for differentiation during embryogenesis., [RefSeq, PubMed]; LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-dependent helicase (PubMed:25219788). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (By similarity). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (PubMed:25219788)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4Z4;Q3UFA0;Q3UJS4;Q91WA7;Q99KN7", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0007417 central nervous system development;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99PU8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIK5-1", "uniprot_id": [ { "id": "DDX21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIK5", "type": "external" } ], "mass": 93551.0, "length": 851, "protein_name": "Nucleolar RNA helicase 2", "gene_name": "Ddx21", "organism": "Mouse", "refseq_name": "nucleolar RNA helicase 2", "refseq_ac": [ { "id": "NP_062426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062426", "type": "external" } ], "gene_names_uniprotkb": "Ddx21", "gene_names_refseq": "D10Ertd645e; D10Wsu42e; Ddx21", "protein_names_uniprotkb": "Nucleolar RNA helicase 2; 3.6.4.13; DEAD box protein 21; Gu-alpha; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 21; DEAD box protein 21; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu); RH II/Gu; RH-II/Gualpha; gu-alpha; nucleolar RNA helicase 2; nucleolar RNA helicase Gu; nucleolar RNA helicase II", "tax_id": 10090, "disease": "", "pathway": " (mmu:56200); (R-MMU-5250924); (R-MMU-6791226)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10860663;17242355;19131326;19144319;21183079;21540332;21703541;22645316;23806337;24788674;25428506;28315936;28528544;29187734;30779550;31219806;31599954;34428180;34887587;35820727;37507081;39627609", "class_list": "", "function": "RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (By similarity). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (By similarity). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (By similarity). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (By similarity). Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVJ3;Q9WV45", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9JIK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY93-1", "uniprot_id": [ { "id": "DCTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY93", "type": "external" } ], "mass": 18795.0, "length": 170, "protein_name": "dCTP pyrophosphatase 1", "gene_name": "Dctpp1", "organism": "Mouse", "refseq_name": "dCTP pyrophosphatase 1", "refseq_ac": [ { "id": "NP_075692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075692", "type": "external" } ], "gene_names_uniprotkb": "Dctpp1; Tdrg-TL1", "gene_names_refseq": "2410015N17Rik; Dctpp1; RS21-C6", "protein_names_uniprotkb": "dCTP pyrophosphatase 1; 3.6.1.12; Deoxycytidine-triphosphatase 1; RS21-C6; dCTPase 1", "protein_names_refseq": "XTP3-transactivated gene A protein homolog; dCTP pyrophosphatase 1; dCTPase 1; deoxycytidine-triphosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66422)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17320107;17850744;19220460;25428506;33725478;34428180", "class_list": "", "function": "Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism., [UniProtKB, PubMed, PubMed]; Several key residues involved in the substrate binding of RS21-C6 have been identified., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.12", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0032556 pyrimidine deoxyribonucleotide binding;GO:0047840 dCTP diphosphatase activity;GO:0000287 magnesium ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006253 dCTP catabolic process;GO:0042262 DNA protection;GO:0009143 nucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QY93-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ28-1", "uniprot_id": [ { "id": "DPOD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ28", "type": "external" } ], "mass": 50836.0, "length": 462, "protein_name": "DNA polymerase delta subunit 3", "gene_name": "Pold3", "organism": "Mouse", "refseq_name": "DNA polymerase delta subunit 3 isoform 2", "refseq_ac": [ { "id": "NP_001355309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355309", "type": "external" } ], "gene_names_uniprotkb": "Pold3", "gene_names_refseq": "2410142G14Rik; P66; P68; Pold3", "protein_names_uniprotkb": "DNA polymerase delta subunit 3; DNA polymerase delta subunit p66", "protein_names_refseq": "DNA polymerase delta subunit 3 isoform 2; DNA polymerase delta subunit 3; DNA polymerase delta subunit p66; GC12; polymerase (DNA directed), delta 3", "tax_id": 10090, "disease": "immunodeficiency 122 (Disease Ontology:DOID:0061088)", "pathway": " (mmu:67967); (R-MMU-110314); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174437); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 19, "publication_count": 6, "publication_id_list": "10219083;21183079;21750661;27524497;31219806;34428180", "class_list": "", "function": "Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (By similarity). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:10219083, PubMed:27524497). Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0042276 error-prone translesion synthesis;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQ28-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60003-1", "uniprot_id": [ { "id": "ELOF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P60003", "type": "external" } ], "mass": 9462.0, "length": 83, "protein_name": "Transcription elongation factor 1 homolog", "gene_name": "Elof1", "organism": "Mouse", "refseq_name": "transcription elongation factor 1 homolog", "refseq_ac": [ { "id": "NP_740747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_740747", "type": "external" } ], "gene_names_uniprotkb": "Elof1", "gene_names_refseq": "1110011K10Rik; Elof1", "protein_names_uniprotkb": "Transcription elongation factor 1 homolog", "protein_names_refseq": "elongation factor 1 homolog (ELF1, S. cerevisiae); transcription elongation factor 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66126)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31276560", "class_list": "", "function": "Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1J7;Q96II4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0005694 chromosome", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60003-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BR27-1", "uniprot_id": [ { "id": "ATOSB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BR27", "type": "external" } ], "mass": 57075.0, "length": 538, "protein_name": "Atos homolog protein B", "gene_name": "Atosb", "organism": "Mouse", "refseq_name": "atos homolog protein B", "refseq_ac": [ { "id": "NP_001240282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240282", "type": "external" } ], "gene_names_uniprotkb": "Atosb; B230312A22Rik; Fam214b; Kiaa1539", "gene_names_refseq": "Atosb; B230312A22Rik; Fam214b", "protein_names_uniprotkb": "Atos homolog protein B", "protein_names_refseq": "atos homolog protein B; family with sequence similarity 214, member B; protein FAM214B", "tax_id": 10090, "disease": "", "pathway": " (mmu:230088)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;29187734;31219806;35319107", "class_list": "", "function": "Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0QZW6;Q3TTG5;Q3U3I3;Q3UEC3;Q69ZG9;Q6IR39", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BR27-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61406-1", "uniprot_id": [ { "id": "EST1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P61406", "type": "external" } ], "mass": 160496.0, "length": 1418, "protein_name": "Telomerase-binding protein EST1A", "gene_name": "Smg6", "organism": "Mouse", "refseq_name": "telomerase-binding protein EST1A", "refseq_ac": [ { "id": "NP_001002764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002764", "type": "external" } ], "gene_names_uniprotkb": "Smg6; Est1a; Kiaa0732", "gene_names_refseq": "Smg6", "protein_names_uniprotkb": "Telomerase-binding protein EST1A; 3.1.-.-; Ever shorter telomeres 1A; Nonsense mediated mRNA decay factor SMG6; Smg-6 homolog", "protein_names_refseq": "EST1-like protein A; Smg-6 homolog, nonsense mediated mRNA decay factor; ever shorter telomeres 1A; nonsense mediated mRNA decay factor SMG6; telomerase subunit EST1A; telomerase-binding protein EST1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:103677); (R-MMU-975957)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17242355;21183079;21750661;24129315;25428506;25770585;26740625;30084848;31219806;34428180;34943873;36259644", "class_list": "", "function": "Cell Type-Specific Role of RNA Nuclease SMG6 in Neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER)., [UniProtKB, UniProtKB]; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA., [UniProtKB, UniProtKB]; SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis., [RefSeq, PubMed]; Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5NC64", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0043021 ribonucleoprotein complex binding;GO:0046872 metal ion binding;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1904354 negative regulation of telomere capping", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61406-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4Z4-1", "uniprot_id": [ { "id": "ETV3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4Z4", "type": "external" } ], "mass": 57026.0, "length": 513, "protein_name": "ETS translocation variant 3", "gene_name": "Etv3", "organism": "Mouse", "refseq_name": "ETS translocation variant 3 isoform 1", "refseq_ac": [ { "id": "NP_001076787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076787", "type": "external" } ], "gene_names_uniprotkb": "Etv3; Mets; Pe1", "gene_names_refseq": "Etv3; METS; Pe1", "protein_names_uniprotkb": "ETS translocation variant 3; ETS domain transcriptional repressor PE1; Mitogenic Ets transcriptional suppressor; PE-1", "protein_names_refseq": "ETS domain transcriptional repressor PE1; ETS translocation variant 3 isoform 1; ETS-domain protein; ets variant gene 3; mitogenic Ets transcriptional suppressor METS", "tax_id": 10090, "disease": "", "pathway": " (mmu:27049)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10913304;12007404;14754893;21183079;21750661;31219806;34428180", "class_list": "", "function": "Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E907;Q9QZW1", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0017151 DEAD/H-box RNA helicase binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4Z4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97360-1", "uniprot_id": [ { "id": "ETV6_MOUSE", "url": "https://www.uniprot.org/uniprot/P97360", "type": "external" } ], "mass": 56406.0, "length": 485, "protein_name": "Transcription factor ETV6", "gene_name": "Etv6", "organism": "Mouse", "refseq_name": "transcription factor ETV6 isoform 1", "refseq_ac": [ { "id": "NP_031987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031987", "type": "external" } ], "gene_names_uniprotkb": "Etv6; Tel1; Tel", "gene_names_refseq": "Etv6; Tel", "protein_names_uniprotkb": "Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel", "protein_names_refseq": "ETS-related protein Tel1; ets variant gene 6 (TEL oncogene); transcription factor ETV6 isoform 1; transcription factor ETV6; translocation-ets-leukemia", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); myeloid neoplasm (Disease Ontology:DOID:0070004); lymphoid leukemia (Disease Ontology:DOID:1037); leukemia (Disease Ontology:DOID:1240); thrombocytopenia (Disease Ontology:DOID:1588); myeloproliferative neoplasm (Disease Ontology:DOID:2226); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:14011)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15060146;18250455;21183079;21750661;25428506;25605945;30084848;34428180;37522715;37670323", "class_list": "", "function": "ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice., [RefSeq, PubMed]; RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]; Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0007296 vitellogenesis;GO:0097152 mesenchymal cell apoptotic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97360-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12710-1", "uniprot_id": [ { "id": "FABPL_MOUSE", "url": "https://www.uniprot.org/uniprot/P12710", "type": "external" } ], "mass": 14246.0, "length": 127, "protein_name": "Fatty acid-binding protein, liver", "gene_name": "Fabp1", "organism": "Mouse", "refseq_name": "fatty acid-binding protein, liver", "refseq_ac": [ { "id": "NP_059095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059095", "type": "external" } ], "gene_names_uniprotkb": "Fabp1; Fabpl", "gene_names_refseq": "Fabp1; Fabpl; L-FABP", "protein_names_uniprotkb": "Fatty acid-binding protein, liver; 14 kDa selenium-binding protein; Fatty acid-binding protein 1; L-FABP; Liver-type fatty acid-binding protein", "protein_names_refseq": "14 kDa selenium-binding protein; fatty acid-binding protein 1; fatty acid-binding protein, liver; liver-type fatty acid-binding protein", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:14080); (R-MMU-163560); (R-MMU-189483); (R-MMU-400206); (R-MMU-9707564)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21183079;23576753;23806337;2760043;34428180;36210013;37453647;37499886;38007237;38417694", "class_list": "", "function": "Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1., [RefSeq, PubMed]; Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion., [RefSeq, PubMed]; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport., [UniProtKB, UniProtKB, UniProtKB]; Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070538 oleic acid binding;GO:0003682 chromatin binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0072546 EMC complex;GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0071926 endocannabinoid signaling pathway;GO:0097017 renal protein absorption;GO:1904659 D-glucose transmembrane transport;GO:0035733 hepatic stellate cell activation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P12710-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26040-1", "uniprot_id": [ { "id": "EZRI_MOUSE", "url": "https://www.uniprot.org/uniprot/P26040", "type": "external" } ], "mass": 69407.0, "length": 586, "protein_name": "Ezrin", "gene_name": "Ezr", "organism": "Mouse", "refseq_name": "ezrin", "refseq_ac": [ { "id": "NP_033536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033536", "type": "external" } ], "gene_names_uniprotkb": "Ezr; Vil2", "gene_names_refseq": "Ezr; Vil2; p81", "protein_names_uniprotkb": "Ezrin; Cytovillin; Villin-2; p81", "protein_names_refseq": "cytovillin; ezrin; villin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22350); (R-MMU-373752); (R-MMU-437239)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "15196952;15797715;1955455;21183079;21289089;21745462;23338238;24285636;25605945;26495903;31219806;32152506;34203471;34428180;37507081;39627609;9456324;9472040", "class_list": "", "function": "Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZT8;Q9DCI1", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044393 microspike;GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0001951 intestinal D-glucose absorption;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0022614 membrane to membrane docking;GO:0030033 microvillus assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P26040-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PH08-1", "uniprot_id": [ { "id": "ERC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PH08", "type": "external" } ], "mass": 110639.0, "length": 957, "protein_name": "ERC protein 2", "gene_name": "Erc2", "organism": "Mouse", "refseq_name": "ERC protein 2 isoform 1", "refseq_ac": [ { "id": "NP_808482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808482", "type": "external" } ], "gene_names_uniprotkb": "Erc2; Cast1; D14Ertd171e; Kiaa0378", "gene_names_refseq": "CAST1/ERC2; CAST1; CAST; D14Ertd171e; ELKS2alpha; Erc2", "protein_names_uniprotkb": "ERC protein 2; CAST1; CAZ-associated structural protein 1", "protein_names_refseq": "CAZ-associated structural protein 1; ERC protein 2 isoform 1; ERC protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:238988)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12163476;17114649;21183079;21750661;27626661;32848054;35822049;40021952;40885482", "class_list": "", "function": "Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80U20;Q8CCP1", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005798 Golgi-associated vesicle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0016082 synaptic vesicle priming;GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6PH08-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921G7-1", "uniprot_id": [ { "id": "ETFD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921G7", "type": "external" } ], "mass": 68091.0, "length": 616, "protein_name": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "gene_name": "Etfdh", "organism": "Mouse", "refseq_name": "electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080070", "type": "external" } ], "gene_names_uniprotkb": "Etfdh", "gene_names_refseq": "0610010I20Rik; Etfdh", "protein_names_uniprotkb": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; 1.5.5.1; ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; Electron-transferring-flavoprotein dehydrogenase", "protein_names_refseq": "ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor; electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "tax_id": 10090, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (mmu:66841); (R-MMU-611105)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16916647;17242355;21183079;23576753;34428180;34678516;34782606;36288343;37453647;37507081;38243131;39927985", "class_list": "", "function": "An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis., [RefSeq, PubMed]; Links fatty acid beta-oxidation and amino acid catabolism to the respiratory chain by transferring electrons from the electron transfer flavoprotein (ETF) to ubiquinone., [UniProtKB, UniProtKB]; Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7K2;Q8BK82;Q9DCT9", "ec_number_list": [ { "id": "1.5.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.1", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0017133 mitochondrial electron transfer flavoprotein complex;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q921G7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4H1-1", "uniprot_id": [ { "id": "EXOC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4H1", "type": "external" } ], "mass": 103959.0, "length": 924, "protein_name": "Exocyst complex component 2", "gene_name": "Exoc2", "organism": "Mouse", "refseq_name": "exocyst complex component 2 isoform 1", "refseq_ac": [ { "id": "NP_079864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079864", "type": "external" } ], "gene_names_uniprotkb": "Exoc2; Sec5l1; Sec5", "gene_names_refseq": "2410030I24Rik; Exoc2; Gm29675; Sec5l1; Sec5", "protein_names_uniprotkb": "Exocyst complex component 2; Exocyst complex component Sec5", "protein_names_refseq": "SEC5 homolog; SEC5-like 1; exocyst complex component 2 isoform 1; exocyst complex component Sec5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66482); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12624092;15557165;18480549;21750661;26582389;31219806;34428180", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The structure of the Ral-binding domain of Sec5, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0090543 Flemming body;GO:0097546 ciliary base;GO:0000145 exocyst;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D4H1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81270-1", "uniprot_id": [ { "id": "ERG_MOUSE", "url": "https://www.uniprot.org/uniprot/P81270", "type": "external" } ], "mass": 54614.0, "length": 486, "protein_name": "Transcriptional regulator ERG", "gene_name": "Erg", "organism": "Mouse", "refseq_name": "transcriptional regulator ERG isoform 2", "refseq_ac": [ { "id": "NP_001289081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289081", "type": "external" } ], "gene_names_uniprotkb": "Erg; Erg-3", "gene_names_refseq": "D030036I24Rik; Erg", "protein_names_uniprotkb": "Transcriptional regulator ERG", "protein_names_refseq": "avian erythroblastosis virus E-26 (v-ets) oncogene related; transcriptional regulator ERG isoform 2; transcriptional regulator ERG", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (mmu:13876)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11791185;21183079;21750661;32871104;34428180;40997131;8413305", "class_list": "", "function": "Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6E7;Q8C5L4;Q920K7;Q920K8;Q920K9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P81270-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RT67-1", "uniprot_id": [ { "id": "DEND3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RT67", "type": "external" } ], "mass": 143888.0, "length": 1274, "protein_name": "DENN domain-containing protein 3", "gene_name": "Dennd3", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 3", "refseq_ac": [ { "id": "NP_001074535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535", "type": "external" } ], "gene_names_uniprotkb": "Dennd3; Kiaa0870", "gene_names_refseq": "Dennd3; E030003N15Rik", "protein_names_uniprotkb": "DENN domain-containing protein 3", "protein_names_refseq": "DENN domain-containing protein 3; DENN/MADD domain containing 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:105841); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21718402;21750661;24719330;25925668;28249939;30084848;36729283", "class_list": "", "function": "DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway., [RefSeq, PubMed]; Dennd3 not only functions as a Rab12-GEF but also modulates Akt signaling in mouse embryonic fibroblast cells, [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ75;Q69ZX2;Q8C6V5", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0008333 endosome to lysosome transport;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2RT67-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFZ9-1", "uniprot_id": [ { "id": "ERLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFZ9", "type": "external" } ], "mass": 37873.0, "length": 340, "protein_name": "Erlin-2", "gene_name": "Erlin2", "organism": "Mouse", "refseq_name": "erlin-2 isoform 1", "refseq_ac": [ { "id": "NP_705820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705820", "type": "external" } ], "gene_names_uniprotkb": "Erlin2; Spfh2", "gene_names_refseq": "Erlin2; Spfh2", "protein_names_uniprotkb": "Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2; SPFH domain-containing protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2", "protein_names_refseq": "SPFH domain family, member 2; SPFH domain-containing protein 2; endoplasmic reticulum lipid raft-associated protein 2; erlin-2 isoform 1; erlin-2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 18A (Disease Ontology:DOID:0070640); hereditary spastic paraplegia 18B (Disease Ontology:DOID:0070641); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:244373); (R-MMU-382556); (R-MMU-9931269)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17502376;21610068;21750661;22872234;25428506;25605945;29187734;30084848;30135210;30899004;31219806;33300544;34428180;36210013", "class_list": "", "function": "Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The erlin2 threonine to isoleucine 65 substitution inhibits erlin1/erlin2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BML8", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0036503 ERAD pathway;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BFZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0G7-1", "uniprot_id": [ { "id": "GARL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0G7", "type": "external" } ], "mass": 115437.0, "length": 1038, "protein_name": "GTPase-activating Rap/Ran-GAP domain-like protein 3", "gene_name": "Garnl3", "organism": "Mouse", "refseq_name": "GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform 3", "refseq_ac": [ { "id": "NP_849219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849219", "type": "external" } ], "gene_names_uniprotkb": "Garnl3", "gene_names_refseq": "Garnl3", "protein_names_uniprotkb": "GTPase-activating Rap/Ran-GAP domain-like protein 3", "protein_names_refseq": "GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform 3; GTPase-activating Rap/Ran-GAP domain-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:99326)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;22517741;34428180;36852467;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNH8;Q8CC22", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3V0G7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925F2-1", "uniprot_id": [ { "id": "ESAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925F2", "type": "external" } ], "mass": 41810.0, "length": 394, "protein_name": "Endothelial cell-selective adhesion molecule", "gene_name": "Esam", "organism": "Mouse", "refseq_name": "endothelial cell-selective adhesion molecule precursor", "refseq_ac": [ { "id": "NP_081378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081378", "type": "external" } ], "gene_names_uniprotkb": "Esam; Esam1", "gene_names_refseq": "2310008D05Rik; Esam1; Esam; W117m", "protein_names_uniprotkb": "Endothelial cell-selective adhesion molecule", "protein_names_refseq": "endothelial cell-selective adhesion molecule precursor; endothelial cell-selective adhesion molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:69524); (R-MMU-202733)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11279107;11847224;12819200;15345747;15383320;21183079;21750661;25428506;30899004;32891959;35820727;37414907", "class_list": "", "function": "Can mediate aggregation most likely through a homophilic molecular interaction., [UniProtKB, PubMed, PubMed]; ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth, [RefSeq, PubMed]; Selectively expressed on endothelial cells and platelets; might be involved in interendothelial cell adhesion, [RefSeq, PubMed]; Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos., [RefSeq, PubMed]; The direct interaction between ESAM and MAGI-1 was confirmed by pull-down experiments. The two proteins formed stable complexes in transfected CHO cells., [RefSeq, PubMed]; Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008104 intracellular protein localization;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q925F2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JEG4-1", "uniprot_id": [ { "id": "A0A0G2JEG4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JEG4", "type": "external" } ], "mass": 1532.0, "length": 14, "protein_name": "Immunoglobulin lambda joining 4", "gene_name": "Iglj4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Iglj4", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin lambda joining 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JEG4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JFD5-1", "uniprot_id": [ { "id": "A0A0G2JFD5_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JFD5", "type": "external" } ], "mass": 30106.0, "length": 256, "protein_name": "Predicted gene, 21083", "gene_name": "Gm21083", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC105242399", "refseq_ac": [ { "id": "NP_001297379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297379", "type": "external" } ], "gene_names_uniprotkb": "Gm21083", "gene_names_refseq": "Gm21083", "protein_names_uniprotkb": "Predicted gene, 21083", "protein_names_refseq": "disks large homolog 5-like; spermatogenesis associated glutamate (E)-rich protein-like; uncharacterized protein LOC105242399", "tax_id": 10090, "disease": "", "pathway": " (mmu:105242399)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JFD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JFU1-1", "uniprot_id": [ { "id": "A0A0G2JFU1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JFU1", "type": "external" } ], "mass": 2207.0, "length": 22, "protein_name": "T cell receptor alpha joining 35", "gene_name": "Traj35", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Traj35", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha joining 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"external" } ], "mass": 31634.0, "length": 267, "protein_name": "Predicted gene, 21680", "gene_name": "Gm21680", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100862368", "refseq_ac": [ { "id": "NP_001365573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365573", "type": "external" } ], "gene_names_uniprotkb": "Gm21680", "gene_names_refseq": "Gm21680", "protein_names_uniprotkb": "Predicted gene, 21680", "protein_names_refseq": "uncharacterized protein LOC100862368", "tax_id": 10090, "disease": "", "pathway": " (mmu:100862368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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Publication Status: Online-Only, [RefSeq, PubMed]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0071230 cellular response to amino acid stimulus;GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1AVK5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z257-1", "uniprot_id": [ { "id": "D3Z257_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z257", "type": "external" } ], "mass": 31241.0, "length": 264, "protein_name": "Predicted gene 5930", "gene_name": "Gm5930", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm5930", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 5930", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z257-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PV38-1", "uniprot_id": [ { "id": "E9PV38_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PV38", "type": "external" } ], "mass": 62721.0, "length": 560, "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2g", "organism": "Mouse", "refseq_name": "carboxylesterase 2-like precursor", "refseq_ac": [ { "id": "NP_932116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932116", "type": "external" } ], "gene_names_uniprotkb": "Ces2g", "gene_names_refseq": "2210023G05Rik; 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Ankrd15; D330024H06Rik; Kank1; mKIAA0172", "protein_names_uniprotkb": "KN motif and ankyrin repeat domains 1; Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 1; KN motif and ankyrin repeat domains 1 isoform 1; ankyrin repeat domain 15; ankyrin repeat domain-containing protein 15; kidney ankyrin repeat-containing protein", "tax_id": 10090, "disease": "spastic quadriplegic cerebral palsy 2 (Disease Ontology:DOID:0081360); cancer (Disease Ontology:DOID:162); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:107351)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;24129315;28284839;29217769;37895296;38891998", "class_list": "", "function": "Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (By similarity). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (By similarity). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (By similarity). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (By similarity). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (By similarity). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (By similarity). In the nucleus, is involved in beta-catenin-dependent activation of transcription (By similarity). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (PubMed:28284839). Potential tumor suppressor for renal cell carcinoma (By similarity)., [UniProtKB, PubMed, UniProtKB]; Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model. Publication Status: Online-Only, [RefSeq, PubMed]; The Protective Role of KANK1 in Podocyte Injury. 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Erratum:[Nat Commun. 2019 Apr 4;10(1):1645. 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breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); morphine dependence (Disease Ontology:DOID:2560); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); teratoma (Disease Ontology:DOID:3307); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); intestinal disease (Disease Ontology:DOID:5295); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); thyroiditis (Disease Ontology:DOID:7166); osteoarthritis (Disease Ontology:DOID:8398); retinal degeneration (Disease Ontology:DOID:8466); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); toxoplasmosis (Disease Ontology:DOID:9965)", "pathway": " (mmu:12028); (R-MMU-111457); (R-MMU-111458); (R-MMU-111461); (R-MMU-111463); (R-MMU-111469); (R-MMU-114294); (R-MMU-5620971); (R-MMU-6804114)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "15383280;16509771;16946732;18248095;19376889;21060336;21750661;22645316;31219806;34203471;34428180;8358790", "class_list": "", "function": "Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 48, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007399 nervous system development;GO:0008283 cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q07813-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQH3-1", "uniprot_id": [ { "id": "VPS35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQH3", "type": "external" } ], "mass": 91713.0, "length": 796, "protein_name": "Vacuolar protein sorting-associated protein 35", "gene_name": "Vps35", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 35", "refseq_ac": [ { "id": "NP_075373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075373", "type": "external" } ], "gene_names_uniprotkb": "Vps35; Mem3", "gene_names_refseq": "Mem3; Vps35", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 35; Maternal-embryonic 3; Vesicle protein sorting 35", "protein_names_refseq": "maternal embryonic message 3; vacuolar protein sorting-associated protein 35; vesicle protein sorting 35", "tax_id": 10090, "disease": "Parkinson's disease 17 (Disease Ontology:DOID:0060897); brain cancer (Disease Ontology:DOID:1319); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:65114); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 34, "publication_id_list": "11112353;16190980;17947660;18299400;19131326;20173027;20875039;21040701;21183079;21920005;21952136;22872234;23395371;25428506;25428507;25605945;26740625;28528544;30084848;30779550;31219806;33300544;33649389;34203471;34428180;34887587;35820727;37453647;37507081;38409392;38831312;39043666;39627609;8678978", "class_list": "", "function": "Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2 and mediates the association of the CSC with the WASH complex (By similarity)., [UniProtKB, UniProtKB]; Intermittent hypoxia training enhances Abeta endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Mutant mice with rod-specific VPS35 deletion exhibit retinal alpha-synuclein pathology-associated degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61123", "ec_number_list": [], "go_molecular_function": "GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030906 retromer, cargo-selective complex;GO:0099073 mitochondrion-derived vesicle;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:2000331 regulation of terminal button organization;GO:0090326 positive regulation of locomotion involved in locomotory behavior;GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9EQH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ88-1", "uniprot_id": [ { "id": "VPS29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ88", "type": "external" } ], "mass": 20496.0, "length": 182, "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "Vps29", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 29 isoform 1", "refseq_ac": [ { "id": "NP_001334382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334382", "type": "external" } ], "gene_names_uniprotkb": "Vps29", "gene_names_refseq": "2010015D08Rik; PEP11; Vps29", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 29; Vesicle protein sorting 29", "protein_names_refseq": "vacuolar protein sorting 29; vacuolar protein sorting-associated protein 29 isoform 1; vacuolar protein sorting-associated protein 29; vacuolar sorting protein 29; vesicle protein sorting 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:56433); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "15965486;20173027;20875039;21040701;21629666;21750661;21920005;24856514;25428506;26740625;30084848;30779550;31599954;34428180", "class_list": "", "function": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (By similarity). Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (By similarity). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that mouse Vps26b-Vps29-Vps35 retromer complex is implicated in the transport of sortilin from endosomes to the trans-Golgi network., [RefSeq, PubMed]; Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCZ0;Q9D107", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0030904 retromer complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0006896 Golgi to vacuole transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QZ88-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS52-1", "uniprot_id": [ { "id": "DGKB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS52", "type": "external" } ], "mass": 90272.0, "length": 802, "protein_name": "Diacylglycerol kinase beta", "gene_name": "Dgkb", "organism": "Mouse", "refseq_name": "diacylglycerol kinase beta isoform 2", "refseq_ac": [ { "id": "NP_848796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848796", "type": "external" } ], "gene_names_uniprotkb": "Dgkb; Kiaa0718", "gene_names_refseq": "6430574F24; 90kda; C630029D13Rik; DAGK2; DGK-beta; DGK; Dgkb; mKIAA0718", "protein_names_uniprotkb": "Diacylglycerol kinase beta; 2.7.1.107; DAG kinase beta; DGK-beta; Diglyceride kinase beta", "protein_names_refseq": "DAG kinase beta; diacylglycerol kinase beta isoform 2; diglyceride kinase beta", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:217480); (R-MMU-114508)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20657643;21183079;21750661;25446448;27495014;33300544", "class_list": "", "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:20657643). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (PubMed:20657643)., [UniProtKB, UniProtKB, PubMed]; Memantine, an NMDA receptor antagonist, improves working memory deficits in Diacylglycerol kinase (DGK) beta knockout mice. These findings may support the hypothesis that DGKbeta has a pivotal role in cognitive function., [RefSeq, PubMed]; Results demonstrate that membrane-localized DGKbeta regulates spine formation by regulation of lipids, contributing to the maintenance of neural networks in synaptic transmission of cognitive processes including memory. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that DGKbeta regulates the spine formation at distal dendrites in medium spiny neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TT5", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NS52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIE6-1", "uniprot_id": [ { "id": "FRM4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIE6", "type": "external" } ], "mass": 113879.0, "length": 1020, "protein_name": "FERM domain-containing protein 4A", "gene_name": "Frmd4a", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 4A isoform 2", "refseq_ac": [ { "id": "NP_001171314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171314", "type": "external" } ], "gene_names_uniprotkb": "Frmd4a; Frmd4; Kiaa1294", "gene_names_refseq": "2700017I06Rik; 5330420J21; C230040M21Rik; Frmd4a; Frmd4; Gm13190; mKIAA1294", "protein_names_uniprotkb": "FERM domain-containing protein 4A", "protein_names_refseq": "FERM domain-containing protein 4A isoform 2; FERM domain-containing protein 4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:209630)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15345747;19144319;20080746;21183079;21750661;22517741;22645316;22872234;31219806;32782141;34428180;35820727", "class_list": "", "function": "Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (PubMed:20080746). Plays a redundant role with FRMD4B in epithelial polarization (PubMed:20080746). May regulate MAPT secretion by activating ARF6-signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B1AXK1;B1AXK2;Q6PDJ4;Q8CHA6", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0050714 positive regulation of protein secretion;GO:0090162 establishment of epithelial cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8BIE6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54946-1", "uniprot_id": [ { "id": "DNJB6_MOUSE", "url": "https://www.uniprot.org/uniprot/O54946", "type": "external" } ], "mass": 39807.0, "length": 365, "protein_name": "DnaJ homolog subfamily B member 6", "gene_name": "Dnajb6", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 6 isoform a", "refseq_ac": [ { "id": "NP_001033029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033029", "type": "external" } ], "gene_names_uniprotkb": "Dnajb6; Hsj2; Mrj", "gene_names_refseq": "Dnajb6; HSJ-2; Mrj; mDj4", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 6; HSJ-2; Heat shock protein J2; MRJ; mDj4", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 6; dnaJ homolog subfamily B member 6 isoform a; dnaJ homolog subfamily B member 6; heat shock protein J2; mammalian relative of DnaJ", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (mmu:23950); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11147971;18163532;18373498;21750661;24129315;32152506;32427588;32976821;33557929;34428180", "class_list": "", "function": "A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:18373498). Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy. Erratum:[J Clin Invest. 2025 May 15;135(10):e194757. doi: 10.1172/JCI194757. PMID: 40371652], [RefSeq, PubMed]; Long non-coding RNA Hsp4 alleviates lipopolysaccharide-induced apoptosis of lung epithelial cells via miRNA-466m-3p/DNAjb6 axis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE94;Q3U6L0;Q3UNJ5;Q3UYT7;Q99LA5;Q9QYI9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0060717 chorion development;GO:0030198 extracellular matrix organization;GO:0045892 negative regulation of DNA-templated transcription;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O54946-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60780-1", "uniprot_id": [ { "id": "GAS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60780", "type": "external" } ], "mass": 48174.0, "length": 421, "protein_name": "Growth arrest-specific protein 7", "gene_name": "Gas7", "organism": "Mouse", "refseq_name": "growth arrest-specific protein 7 isoform g", "refseq_ac": [ { "id": "NP_001389754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389754", "type": "external" } ], "gene_names_uniprotkb": "Gas7", "gene_names_refseq": "B230343A10Rik; Gas7-cb; Gas7", "protein_names_uniprotkb": "Growth arrest-specific protein 7; GAS-7", "protein_names_refseq": "growth arrest-specific 7 protein; growth arrest-specific protein 7 isoform g; growth arrest-specific protein 7", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 13, "publication_id_list": "10552931;14515354;15070702;21183079;21750661;22645316;27802388;28895026;31219806;31628328;34428180;34678516;9736752", "class_list": "", "function": "Gas7 in PC12 cells leads to an expanded cell morphology and promotes neurite formation. These processes undergo elongation upon addition of nerve growth factor (NGF)., [RefSeq, PubMed]; Gas7-related M1 gene expression in alveolar macrophage was not dependent on NF-kappaB and STAT1 pathway, [RefSeq, PubMed]; Growth Arrest-Specific 7 (GAS7) plays a critical role in phagocytic cup formation in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Hoxa7 and Hoxa9 contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis, [RefSeq, PubMed]; May play a role in promoting maturation and morphological differentiation of cerebellar neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY25;Q9QY26;Q9QY34", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0051017 actin filament bundle assembly;GO:0030182 neuron differentiation;GO:0008360 regulation of cell shape;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q60780-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08734-1", "uniprot_id": [ { "id": "BAK_MOUSE", "url": "https://www.uniprot.org/uniprot/O08734", "type": "external" } ], "mass": 23295.0, "length": 209, "protein_name": "Bcl-2 homologous antagonist/killer", "gene_name": "Bak1", "organism": "Mouse", "refseq_name": "bcl-2 homologous antagonist/killer", "refseq_ac": [ { "id": "NP_031549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031549", "type": "external" } ], "gene_names_uniprotkb": "Bak1; Bak", "gene_names_refseq": "Bak1; Bak; N-BAK1; N-Bak", "protein_names_uniprotkb": "Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK", "protein_names_refseq": "Bcl2 homologous antagonist/killer; apoptosis regulator BAK; bcl-2 homologous antagonist/killer", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); leiomyoma (Disease Ontology:DOID:127); ataxia telangiectasia (Disease Ontology:DOID:12704); cervix carcinoma (Disease Ontology:DOID:2893); intermittent claudication (Disease Ontology:DOID:3669); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:12018); (R-MMU-111452); (R-MMU-111457); (R-MMU-111458); (R-MMU-111461); (R-MMU-111463); (R-MMU-111469); (R-MMU-5620971)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "16509771;18248095;18462686;21750661;34428180;9299236", "class_list": "", "function": "In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QM21;Q8C264", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010332 response to gamma radiation;GO:0010629 negative regulation of gene expression;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08734-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97784-1", "uniprot_id": [ { "id": "CRY1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97784", "type": "external" } ], "mass": 68001.0, "length": 606, "protein_name": "Cryptochrome-1", "gene_name": "Cry1", "organism": "Mouse", "refseq_name": "cryptochrome-1 isoform a", "refseq_ac": [ { "id": "NP_031797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031797", "type": "external" } ], "gene_names_uniprotkb": "Cry1", "gene_names_refseq": "Cry1; Phll1", "protein_names_uniprotkb": "Cryptochrome-1", "protein_names_refseq": "cryptochrome 1 (photolyase-like); cryptochrome-1 isoform a; cryptochrome-1", "tax_id": 10090, "disease": "delayed sleep phase syndrome (Disease Ontology:DOID:0111141); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:12952)", "pathway_count": 1, "publication_count": 57, "publication_id_list": "10428031;10521578;11779462;11875063;11889036;14701732;15226430;15298678;16478995;16628007;16717091;16790549;17310242;17462724;18953409;19129230;19299583;19833968;19917250;20159955;20385766;20852621;21236481;21613214;21750661;21768648;22170608;22798407;23133559;23303907;23418588;23452855;23452856;23531614;23575670;23616524;23746849;23916625;24089055;24158435;24378737;24385426;24489120;25428506;26431207;26776516;27123980;28683290;28751364;28790135;29561690;29937374;30500822;31599954;34428180;9600923;9801304", "class_list": "", "function": "This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1, ATF4, MTA1, KLF10 and NAMPT. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (PubMed:28683290). Plays an essential role in the generation of circadian rhythms in the retina (PubMed:29561690). Represses the transcriptional activity of NR1I2 (PubMed:28751364)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0071949 FAD binding;GO:0042826 histone deacetylase binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:2000850 negative regulation of glucocorticoid secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "P97784-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZW4-1", "uniprot_id": [ { "id": "CPNE5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZW4", "type": "external" } ], "mass": 65592.0, "length": 593, "protein_name": "Copine-5", "gene_name": "Cpne5", "organism": "Mouse", "refseq_name": "copine-5 isoform 2", "refseq_ac": [ { "id": "NP_694806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694806", "type": "external" } ], "gene_names_uniprotkb": "Cpne5", "gene_names_refseq": "A830083G22Rik; Cpne5", "protein_names_uniprotkb": "Copine-5; Copine V", "protein_names_refseq": "copine-5 isoform 2; copine-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:240058)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18614158;20173027;21183079;21750661", "class_list": "", "function": "Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]., [RefSeq]; Our results demonstrate that CPNE5 is expressed in both neural progenitor cells and the differentiated neurons during the neural development, which suggests that CPNE5 might play an important role in the development of murine central nervous system., [RefSeq, PubMed]; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0043005 neuron projection;GO:0042995 cell projection", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JZW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97315-1", "uniprot_id": [ { "id": "CSRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97315", "type": "external" } ], "mass": 20583.0, "length": 193, "protein_name": "Cysteine and glycine-rich protein 1", "gene_name": "Csrp1", "organism": "Mouse", "refseq_name": "cysteine and glycine-rich protein 1", "refseq_ac": [ { "id": "NP_031817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031817", "type": "external" } ], "gene_names_uniprotkb": "Csrp1; Crp1; Csrp", "gene_names_refseq": "CRP1; Csrp1; Csrp", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 1; CRP1; CRP; Cysteine-rich protein 1", "protein_names_refseq": "CRP; cysteine and glycine-rich protein 1; cysteine rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13007)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10090149;17114649;21183079;22645316;23806337;26495903;31219806;32782141;32848054;34428180;35820727;37507081;39927985;40021952", "class_list": "", "function": "Could play a role in neuronal development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030018 Z disc", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0045214 sarcomere organization;GO:0060537 muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P97315-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SUQ9-1", "uniprot_id": [ { "id": "CTC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SUQ9", "type": "external" } ], "mass": 134028.0, "length": 1212, "protein_name": "CST complex subunit CTC1", "gene_name": "Ctc1", "organism": "Mouse", "refseq_name": "CST complex subunit CTC1 isoform a", "refseq_ac": [ { "id": "NP_001013274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013274", "type": "external" } ], "gene_names_uniprotkb": "Ctc1; 1500010J02Rik", "gene_names_refseq": "1500010J02Rik; AAF-132; AAF132; Ctc1", "protein_names_uniprotkb": "CST complex subunit CTC1; AAF-132; AAF132; Alpha-accessory factor of 132 kDa; Conserved telomere maintenance component 1", "protein_names_refseq": "CST complex subunit CTC1 isoform a; CST complex subunit CTC1; alpha accessory factor 132; alpha-accessory factor of 132 kDa; conserved telomere maintenance component 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68964); (R-MMU-174411); (R-MMU-174430)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "19119139;19854130;21750661;22531781;22748632;25605945;31219806;34203471;34428180", "class_list": "", "function": "Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Involved in telomere maintenance. Involved in genome stability (By similarity). May be in involved in telomeric C-strand fill-in during late S/G2 phase (PubMed:22748632)., [UniProtKB, UniProtKB, PubMed, PubMed]; These data demonstrate an essential role for CTC1 in promoting efficient replication and length maintenance of telomeres., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RW14;Q3UKQ1;Q6P9S2;Q8BRK2;Q91WN0;Q9CW32", "ec_number_list": [], "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0042162 telomeric DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region;GO:1990879 CST complex", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0035264 multicellular organism growth;GO:0000723 telomere maintenance;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5SUQ9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61164-1", "uniprot_id": [ { "id": "CTCF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61164", "type": "external" } ], "mass": 83745.0, "length": 736, "protein_name": "Transcriptional repressor CTCF", "gene_name": "Ctcf", "organism": "Mouse", "refseq_name": "transcriptional repressor CTCF isoform 1", "refseq_ac": [ { "id": "NP_851839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851839", "type": "external" } ], "gene_names_uniprotkb": "Ctcf", "gene_names_refseq": "Ctcf", "protein_names_uniprotkb": "Transcriptional repressor CTCF; 11-zinc finger protein; CCCTC-binding factor; CTCFL paralog", "protein_names_refseq": "11-zinc finger protein; CTCFL paralog; transcriptional repressor CTCF isoform 1; transcriptional repressor CTCF", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); autosomal dominant intellectual developmental disorder 21 (Disease Ontology:DOID:0070051); childhood acute lymphocytic leukemia (Disease Ontology:DOID:0080144); breast cancer (Disease Ontology:DOID:1612); basal cell carcinoma (Disease Ontology:DOID:2513); skin squamous cell carcinoma (Disease Ontology:DOID:3151); breast carcinoma (Disease Ontology:DOID:3459); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:13018)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11743158;11997516;15669143;16614224;16949368;16951251;17329968;17952071;18614575;19029252;25428506;26276636;26527277;26961175;28388437;30676316;34428180;34856126;39627609;40128797;40997131;8649389", "class_list": "", "function": "Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:26276636, PubMed:26527277, PubMed:28388437, PubMed:34856126). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:26276636, PubMed:26527277, PubMed:28388437, PubMed:34856126). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:28388437). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16614224). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (PubMed:16614224). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (PubMed:16614224). Regulates asynchronous replication of IGF2/H19 (PubMed:17329968). Plays a critical role in gene silencing over considerable distances in the genome (PubMed:16951251). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (By similarity). Inversely, binding to target sites is prevented by CpG methylation (By similarity). Plays an important role in chromatin remodeling (By similarity). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:16951251). When bound to chromatin, it provides an anchor point for nucleosomes positioning (By similarity). Seems to be essential for homologous X-chromosome pairing (PubMed:17952071). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158, PubMed:15669143, PubMed:17952071). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158, PubMed:15669143, PubMed:17952071). Involved in sister chromatid cohesion (By similarity). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (By similarity). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (By similarity). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (By similarity). Also binds to the PLK and PIM1 promoters (By similarity). Acts as a transcriptional activator of APP (By similarity). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (By similarity). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (PubMed:18614575). Seems to act as tumor suppressor (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Conserved CTCF insulator elements flank the mouse and human beta-globin loci., [RefSeq, PubMed]; It's proposed that Tsix and CTCF together establish a regulatable epigenetic switch for X-inactivation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0000793 condensed chromosome", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61164-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AC93-1", "uniprot_id": [ { "id": "DNAI2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AC93", "type": "external" } ], "mass": 70968.0, "length": 623, "protein_name": "Dynein axonemal intermediate chain 2", "gene_name": "Dnai2", "organism": "Mouse", "refseq_name": "dynein axonemal intermediate chain 2", "refseq_ac": [ { "id": "NP_001030050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050", "type": "external" } ], "gene_names_uniprotkb": "Dnai2; Dnaic2", "gene_names_refseq": "C030015H18Rik; Dnai2; Dnaic2; Gm728; b2b3405Clo", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 2; Axonemal dynein intermediate chain 2", "protein_names_refseq": "dynein axonemal intermediate chain 2; dynein intermediate chain 2, axonemal; dynein, axonemal, intermediate polypeptide 2", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 9 (Disease Ontology:DOID:0110622); sensorineural hearing loss (Disease Ontology:DOID:10003); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:432611)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18547164;19052621;21750661;24421334;30387321;33347437;37352829;37458246", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Part of the dynein complex of respiratory cilia., [UniProtKB, UniProtKB]; Dnaic2 plays a role in oogenesis and spermatogenesis by activation of Stat3., [RefSeq, PubMed]; These data suggest that Dnaic2 plays a role in ovarian follicular development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC94", "ec_number_list": [], "go_molecular_function": "GO:0003777 microtubule motor activity;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0009897 external side of plasma membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2AC93-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWR8-1", "uniprot_id": [ { "id": "DNM3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWR8", "type": "external" } ], "mass": 47993.0, "length": 421, "protein_name": "DNA (cytosine-5)-methyltransferase 3-like", "gene_name": "Dnmt3l", "organism": "Mouse", "refseq_name": "DNA (cytosine-5)-methyltransferase 3-like isoform 1", "refseq_ac": [ { "id": "NP_001075164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075164", "type": "external" } ], "gene_names_uniprotkb": "Dnmt3l", "gene_names_refseq": "D6Ertd14e; Dnmt3l; ecat7", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3-like", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3-like isoform 1; DNA (cytosine-5-)-methyltransferase 3-like", "tax_id": 10090, "disease": "choline deficiency disease (Disease Ontology:DOID:8456)", "pathway": " (mmu:54427)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11306809;11719692;15318244;15671018;17060371;18945701;21750661;24074865;32674113;38627502", "class_list": "", "function": "Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (PubMed:11719692, PubMed:15318244, PubMed:15671018, PubMed:24074865). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:15671018). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:15671018). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity). Plays a key role in embryonic stem cells and germ cells (PubMed:11719692, PubMed:15318244, PubMed:24074865). In germ cells, required for the methylation of imprinted loci together with DNMT3A (PubMed:11719692). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (PubMed:15318244). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (PubMed:24074865). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (PubMed:24074865). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (PubMed:24074865). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (PubMed:24074865)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells. Publication Status: Online-Only, [RefSeq, PubMed]; CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]; Likely to function not directly as a DNA methyltransferase but as a regulator of methylation at imprinted loci, [RefSeq, PubMed]; Sex-specific promoters control Dnmt3L expression in the mouse germ line, mirroring the situation at the Dnmt1 and Dnmt3A loci., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:1902494 catalytic complex", "go_biological_process": "GO:0060718 chorionic trophoblast cell differentiation;GO:0007283 spermatogenesis;GO:0048863 stem cell differentiation;GO:0090310 negative regulation of DNA methylation-dependent heterochromatin formation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CWR8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08274-1", "uniprot_id": [ { "id": "DMWD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08274", "type": "external" } ], "mass": 69816.0, "length": 665, "protein_name": "Dystrophia myotonica WD repeat-containing protein", "gene_name": "Dmwd", "organism": "Mouse", "refseq_name": "dystrophia myotonica WD repeat-containing protein isoform 1", "refseq_ac": [ { "id": "NP_034188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034188", "type": "external" } ], "gene_names_uniprotkb": "Dmwd; Dm9", "gene_names_refseq": "DMR-N9; Dm9; Dmwd", "protein_names_uniprotkb": "Dystrophia myotonica WD repeat-containing protein; Dystrophia myotonica-containing WD repeat motif protein; Protein DMR-N9", "protein_names_refseq": "dystrophia myotonica WD repeat-containing protein isoform 1; dystrophia myotonica WD repeat-containing protein; dystrophia myotonica linked gene, N9; dystrophia myotonica-containing WD repeat motif protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13401)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12691844;1302022;21750661;24129315;31219806;31599954;7633444", "class_list": "", "function": "Regulator of the deubiquitinating USP12/DMWD/WDR48 complex. Functions as a cofactor that promotes USP12 enzymatic activity., [UniProtKB, UniProtKB]; The DMWD protein level gradually increased, was expressed specifically in the neuropil of areas with a high density of synaptic connections and was dispersed in a punctuate fashion throughout the neural cell body, but excluded from axons, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QLY4", "ec_number_list": [], "go_molecular_function": "GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043204 perikaryon;GO:1905368 peptidase complex", "go_biological_process": "GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08274-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1M6-12", "uniprot_id": [ { "id": "DNM1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1M6", "type": "external" } ], "mass": 81825.0, "length": 736, "protein_name": "Dynamin-1-like protein", "gene_name": "Dnm1l", "organism": "Mouse", "refseq_name": "dynamin-1-like protein isoform b", "refseq_ac": [ { "id": "NP_001021118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001021118", "type": "external" } ], "gene_names_uniprotkb": "Dnm1l; Drp1", "gene_names_refseq": "6330417M19Rik; Dlp1; Dnm1l; Dnmlp1; Drp1; python", "protein_names_uniprotkb": "Dynamin-1-like protein; 3.6.5.5; Dymple; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-related protein 1", "protein_names_refseq": "dymple; dynamin family member proline-rich carboxyl-terminal domain less; dynamin-1-like protein isoform b; dynamin-1-like protein; dynamin-related protein 1", "tax_id": 10090, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 1 (Disease Ontology:DOID:0070347); optic atrophy 5 (Disease Ontology:DOID:0111438); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); dental fluorosis (Disease Ontology:DOID:13711); Parkinson's disease (Disease Ontology:DOID:14330); pulmonary fibrosis (Disease Ontology:DOID:3770); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:74006); (R-MMU-75153)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;14592431;19349686;19578372;19752021;22564413;23283981;23806337;24508339;25192600;29478834;29853636;30059978;30084848;31603426;32484300;33422108;9422767", "class_list": "", "function": "Functions in mitochondrial and peroxisomal division (PubMed:19578372, PubMed:19752021, PubMed:22564413, PubMed:23283981, PubMed:24508339, PubMed:29478834, PubMed:29853636, PubMed:32484300). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:24508339). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:24508339). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:24508339). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (By similarity). Required for formation of endocytic vesicles (By similarity). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (PubMed:19752021, PubMed:22564413). Required for normal brain development, including that of cerebellum (PubMed:19578372, PubMed:22564413). Facilitates developmentally regulated apoptosis during neural tube formation (PubMed:19578372). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (PubMed:19578372). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (By similarity). Required for programmed necrosis execution (By similarity). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mitochondrial fragmentation in acute kidney injury involves the activation of mitochondrial fission via Drp1., [RefSeq, PubMed]; Regulates postsynaptic clathrin-mediated endocytosis by positioning the endocytic zone at the postsynaptic density, independently of mitochondrial division., [UniProtKB, PubMed]; This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PUD2;Q8BNQ5;Q8BQ64;Q8CGD0;Q8K1A1", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0051433 BH2 domain binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0098835 presynaptic endocytic zone membrane;GO:0099073 mitochondrion-derived vesicle;GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0070585 protein localization to mitochondrion;GO:0090149 mitochondrial membrane fission;GO:1900063 regulation of peroxisome organization;GO:1900244 positive regulation of synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8K1M6-12", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ28-1", "uniprot_id": [ { "id": "DPH6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ28", "type": "external" } ], "mass": 29922.0, "length": 267, "protein_name": "Diphthine--ammonia ligase", "gene_name": "Dph6", "organism": "Mouse", "refseq_name": "diphthine--ammonia ligase isoform 2", "refseq_ac": [ { "id": "NP_079951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079951", "type": "external" } ], "gene_names_uniprotkb": "Dph6; Atpbd4", "gene_names_refseq": "5730421E18Rik; Atpbd4; Dph6", "protein_names_uniprotkb": "Diphthine--ammonia ligase; 6.3.1.14; ATP-binding domain-containing protein 4; Diphthamide synthase; Diphthamide synthetase; Protein DPH6 homolog", "protein_names_refseq": "ATP binding domain 4; ATP-binding domain-containing protein 4; diphthamide synthase; diphthamide synthetase; diphthine--ammonia ligase isoform 2; diphthine--ammonia ligase; protein DPH6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66632); (R-MMU-5358493)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15592455", "class_list": "", "function": "Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor 2 (EEF2) to diphthamide (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL00;Q8R1W5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.3.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.14", "type": "external" } ], "go_molecular_function": "GO:0017178 diphthine-ammonia ligase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D772-1", "uniprot_id": [ { "id": "F219A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D772", "type": "external" } ], "mass": 17464.0, "length": 157, "protein_name": "Protein FAM219A", "gene_name": "Fam219a", "organism": "Mouse", "refseq_name": "protein FAM219A isoform 1", "refseq_ac": [ { "id": "NP_001153055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153055", "type": "external" } ], "gene_names_uniprotkb": "Fam219a; 2310028H24Rik", "gene_names_refseq": "2310028H24Rik; Fam219a", "protein_names_uniprotkb": "Protein FAM219A", "protein_names_refseq": "likely ortholog of H. sapiens chromosome 9 open reading frame 25 (C9orf25); protein FAM219A isoform 1; protein FAM219A; uncharacterized protein C9orf25 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71901)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANP3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D772-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UYR4-1", "uniprot_id": [ { "id": "ESPNL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UYR4", "type": "external" } ], "mass": 108868.0, "length": 1005, "protein_name": "Espin-like protein", "gene_name": "Espnl", "organism": "Mouse", "refseq_name": "espin-like protein", "refseq_ac": [ { "id": "NP_001028464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028464", "type": "external" } ], "gene_names_uniprotkb": "Espnl; Gm556", "gene_names_refseq": "Espnl; Gm556", "protein_names_uniprotkb": "Espin-like protein", "protein_names_refseq": "espin-like protein", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 36 (Disease Ontology:DOID:0110494)", "pathway": " (mmu:227357)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25582750;26926603", "class_list": "", "function": "Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032426 stereocilium tip;GO:0032420 stereocilium", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UYR4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70424-1", "uniprot_id": [ { "id": "ERBB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70424", "type": "external" } ], "mass": 138579.0, "length": 1256, "protein_name": "Receptor tyrosine-protein kinase erbB-2", "gene_name": "Erbb2", "organism": "Mouse", "refseq_name": "receptor tyrosine-protein kinase erbB-2 precursor", "refseq_ac": [ { "id": "NP_001003817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003817", "type": "external" } ], "gene_names_uniprotkb": "Erbb2; Kiaa3023; Neu", "gene_names_refseq": "Erbb-2; Erbb2; HER-2; HER2; Neu; c-erbB2; c-neu; l11Jus8; mKIAA3023", "protein_names_uniprotkb": "Receptor tyrosine-protein kinase erbB-2; 2.7.10.1; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; p185erbB2", "protein_names_refseq": "Neu oncogene; avian erythroblastosis oncogene B 2; c-erbB-2; p185erbB2; proto-oncogene NEU; proto-oncogene c-ErbB-2; receptor tyrosine-protein kinase erbB-2 precursor; receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ductal carcinoma in situ (Disease Ontology:DOID:0060074); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); HELLP syndrome (Disease Ontology:DOID:13133); lung cancer (Disease Ontology:DOID:1324); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); mammary Paget's disease (Disease Ontology:DOID:3443); invasive lobular carcinoma (Disease Ontology:DOID:3457); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:13866); (R-MMU-1227986); (R-MMU-1250196); (R-MMU-1257604); (R-MMU-1306955); (R-MMU-1358803); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-416572); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8863795); (R-MMU-9652282)", "pathway_count": 15, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11278603;20173027;23897819;25428506;27891225;30084848;30779550;31219806;34428180;37828378;39067134;7542762;7589796;9048643", "class_list": "", "function": "A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice., [RefSeq, PubMed]; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity)., [UniProtKB]; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 3, "disease_count": 34, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q61525;Q6ZPE0", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0015026 coreceptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0038127 ERBB signaling pathway;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P70424-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U7R1-1", "uniprot_id": [ { "id": "ESYT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U7R1", "type": "external" } ], "mass": 121554.0, "length": 1092, "protein_name": "Extended synaptotagmin-1", "gene_name": "Esyt1", "organism": "Mouse", "refseq_name": "extended synaptotagmin-1", "refseq_ac": [ { "id": "NP_035973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035973", "type": "external" } ], "gene_names_uniprotkb": "Esyt1; Fam62a; Mbc2", "gene_names_refseq": "Esyt1; Fam62a; Mbc2; vp115", "protein_names_uniprotkb": "Extended synaptotagmin-1; E-Syt1; Membrane-bound C2 domain-containing protein", "protein_names_refseq": "E-Syt1; extended synaptotagmin-1; family with sequence similarity 62 (C2 domain containing), member A; membrane-bound C2 domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:23943); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-9845576)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10350628;19255425;21183079;21750661;26495903;30084848;31219806;34428180;36210013;39627609", "class_list": "", "function": "Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G protein-coupled receptor activity in absence of cytosolic calcium (By similarity). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Insulin-activated Cdk5 phosphorylates E-Syt1, which associates with GLUT4, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8R1;Q91X62;Q9CVH0;Q9Z1X5;Q9Z1X6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0120009 intermembrane lipid transfer;GO:0061817 endoplasmic reticulum-plasma membrane tethering;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3U7R1-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61526-1", "uniprot_id": [ { "id": "ERBB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61526", "type": "external" } ], "mass": 147613.0, "length": 1339, "protein_name": "Receptor tyrosine-protein kinase erbB-3", "gene_name": "Erbb3", "organism": "Mouse", "refseq_name": "receptor tyrosine-protein kinase erbB-3 precursor", "refseq_ac": [ { "id": "NP_034283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034283", "type": "external" } ], "gene_names_uniprotkb": "Erbb3", "gene_names_refseq": "Erbb-3; Erbb3r; Erbb3; Her3", "protein_names_uniprotkb": "Receptor tyrosine-protein kinase erbB-3; 2.7.10.1; Glial growth factor receptor; Proto-oncogene-like protein c-ErbB-3", "protein_names_refseq": "avian erythroblastosis oncogene B 3 receptor; c-erbB-3; glial growth factor receptor; proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3 precursor; receptor tyrosine-protein kinase erbB-3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ductal carcinoma in situ (Disease Ontology:DOID:0060074); lethal congenital contracture syndrome 2 (Disease Ontology:DOID:0060560); neuronal intestinal dysplasia type A (Disease Ontology:DOID:0080679); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); stomach carcinoma (Disease Ontology:DOID:5517); median neuropathy (Disease Ontology:DOID:571); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:13867); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1257604); (R-MMU-1306955); (R-MMU-1358803); (R-MMU-1963642); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8863795)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12824184;23897819;25428506;30084848;30899004;31219806;34428180;38944125;7589796", "class_list": "", "function": "ErbB3 is required for hyperaminoacidemia-induced pancreatic alpha cell hyperplasia., [RefSeq, PubMed]; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 22, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQR1;Q68J64;Q810U8;Q8K317", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:0038132 neuregulin binding;GO:0004888 transmembrane signaling receptor activity;GO:0005524 ATP binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0043235 receptor complex", "go_biological_process": "GO:0021545 cranial nerve development;GO:0038127 ERBB signaling pathway;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q61526-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C729-1", "uniprot_id": [ { "id": "HYCC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C729", "type": "external" } ], "mass": 58587.0, "length": 530, "protein_name": "Hyccin 2", "gene_name": "Hycc2", "organism": "Mouse", "refseq_name": "hyccin 2 isoform a", "refseq_ac": [ { "id": "NP_001297527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297527", "type": "external" } ], "gene_names_uniprotkb": "Hycc2; D1Ertd53e; Fam126b", "gene_names_refseq": "C130065N10Rik; D1Ertd53e; D630010C10; Fam126b; Hycc2", "protein_names_uniprotkb": "Hyccin 2", "protein_names_refseq": "family with sequence similarity 126, member B; hyccin 2 isoform a; hyccin 2; protein FAM126B", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 5 (Disease Ontology:DOID:0060793)", "pathway": " (mmu:213056)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;26571211;30084848;34428180;35822049;36757814;40021952;40885482", "class_list": "", "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMY7;Q6NV64", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C729-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAS9-1", "uniprot_id": [ { "id": "GBG12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAS9", "type": "external" } ], "mass": 7997.0, "length": 72, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "gene_name": "Gng12", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "refseq_ac": [ { "id": "NP_001171027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171027", "type": "external" } ], "gene_names_uniprotkb": "Gng12", "gene_names_refseq": "2010305F15Rik; Gng12; Hg3a", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; heterotrimeric guanine nucleotide-binding protein 3a", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14701); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 5, "publication_id_list": "19144319;19568691;21183079;21750661;34428180", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Modulating Gng12 mRNA levels using RNAi revealed a novel role for the factor in the negative regulation of the overall inflammatory response as based on effects on nitrite and TNFalpha levels. Erratum:[Inflamm Res. 2009 Oct;58(10):725], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544P3", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0031681 G-protein beta-subunit binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005884 actin filament;GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DAS9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70338-1", "uniprot_id": [ { "id": "GFI1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70338", "type": "external" } ], "mass": 45944.0, "length": 423, "protein_name": "Zinc finger protein Gfi-1", "gene_name": "Gfi1", "organism": "Mouse", "refseq_name": "zinc finger protein Gfi-1 isoform 1", "refseq_ac": [ { "id": "NP_034408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034408", "type": "external" } ], "gene_names_uniprotkb": "Gfi1; Gfi-1", "gene_names_refseq": "Gfi-1; Gfi1; Pal-1; Pal1", "protein_names_uniprotkb": "Zinc finger protein Gfi-1; Growth factor independent protein 1", "protein_names_refseq": "growth factor independent protein 1; zinc finger protein Gfi-1 isoform 1; zinc finger protein Gfi-1", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); myelodysplastic syndrome (Disease Ontology:DOID:0050908); severe congenital neutropenia 2 (Disease Ontology:DOID:0112131); leukemia (Disease Ontology:DOID:1240); alcohol use disorder (Disease Ontology:DOID:1574); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:14581)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11801660;12441305;16819553;17197705;17707228;20547752;21750661;29651020;8622900;8887656;8985317", "class_list": "", "function": "Transcription repressor essential for hematopoiesis (PubMed:8622900). Functions in a cell-context and development-specific manner (By similarity). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (By similarity). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:17197705). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (PubMed:17197705). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (PubMed:16819553). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (By similarity). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (By similarity). Required for the maintenance of inner ear hair cells (PubMed:12441305). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response (PubMed:29651020). Facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09063", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0016363 nuclear matrix", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:0007638 mechanosensory behavior", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70338-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1EGX6-1", "uniprot_id": [ { "id": "FSCB_MOUSE", "url": "https://www.uniprot.org/uniprot/A1EGX6", "type": "external" } ], "mass": 114979.0, "length": 1074, "protein_name": "Fibrous sheath CABYR-binding protein", "gene_name": "Fscb", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fscb", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibrous sheath CABYR-binding protein; PKA-phosphorylated calcium and CABYR-binding protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:623046)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17855365;21750661;21871179;27398160", "class_list": "", "function": "May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0035686 sperm fibrous sheath;GO:0097228 sperm principal piece", "go_biological_process": "GO:0033234 negative regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1EGX6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FD7-1", "uniprot_id": [ { "id": "FNIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FD7", "type": "external" } ], "mass": 130126.0, "length": 1165, "protein_name": "Folliculin-interacting protein 1", "gene_name": "Fnip1", "organism": "Mouse", "refseq_name": "folliculin-interacting protein 1", "refseq_ac": [ { "id": "NP_776114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776114", "type": "external" } ], "gene_names_uniprotkb": "Fnip1; Kiaa1961", "gene_names_refseq": "A730024A03Rik; Fnip1", "protein_names_uniprotkb": "Folliculin-interacting protein 1", "protein_names_refseq": "folliculin-interacting protein 1", "tax_id": 10090, "disease": "immunodeficiency 93 (Disease Ontology:DOID:0061063)", "pathway": " (mmu:216742); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "15345747;17242355;19144319;21183079;21750661;22709692;23582324;25775561;27303042;29897930;30084848;32941802;34203471;34428180;34562363;35412553;36210013;37079666;37932296;38324677;38838134", "class_list": "", "function": "AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise., [RefSeq, PubMed]; Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (By similarity). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (By similarity). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (PubMed:32941802). Required for B-cell development (PubMed:22709692, PubMed:27303042)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment. Publication Status: Online-Only, [RefSeq, PubMed]; FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics., [RefSeq, PubMed]; Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80T72;Q8BQM0", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0051087 protein-folding chaperone binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0002327 immature B cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q68FD7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVH4-1", "uniprot_id": [ { "id": "FOXO3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVH4", "type": "external" } ], "mass": 71064.0, "length": 672, "protein_name": "Forkhead box protein O3", "gene_name": "Foxo3", "organism": "Mouse", "refseq_name": "forkhead box protein O3", "refseq_ac": [ { "id": "NP_062714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062714", "type": "external" } ], "gene_names_uniprotkb": "Foxo3; Fkhr2; Foxo3a", "gene_names_refseq": "1110048B16Rik; 2010203A17Rik; FKHRL1; Fkhr2; Foxo3a; Foxo3", "protein_names_uniprotkb": "Forkhead box protein O3", "protein_names_refseq": "forkhead box O3a; forkhead box protein O3; forkhead protein FKHR2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); endometrial adenocarcinoma (Disease Ontology:DOID:2870); temporal lobe epilepsy (Disease Ontology:DOID:3328); dermoid cyst of ovary (Disease Ontology:DOID:5117); rheumatoid arthritis (Disease Ontology:DOID:7148); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56484); (R-MMU-1181150); (R-MMU-198693); (R-MMU-5687128); (R-MMU-9607240); (R-MMU-9614399); (R-MMU-9617629); (R-MMU-9617828); (R-MMU-9634638); (R-MMU-9841251)", "pathway_count": 10, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;11353388;11875118;11884717;17521387;18054315;18054316;20332342;21183079;21750661;22510882;22586590;23283301;23805378;23806337;23964069;24174672;25402684;25428506;25605945;26694365;28851713;29445193;30084848;30779550;32103177;32850784;33510167;34428180;38886174;40997131", "class_list": "", "function": "Expression in the ovary, [RefSeq, PubMed]; Redox regulation through a p66shc-dependent signaling pathway, [RefSeq, PubMed]; Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:18054315, PubMed:18054316, PubMed:23805378). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (PubMed:18054315, PubMed:18054316, PubMed:25402684). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z6Y6;Q05CZ4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0001544 initiation of primordial ovarian follicle growth;GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q9WVH4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97489-1", "uniprot_id": [ { "id": "GATA5_MOUSE", "url": "https://www.uniprot.org/uniprot/P97489", "type": "external" } ], "mass": 42114.0, "length": 404, "protein_name": "Transcription factor GATA-5", "gene_name": "Gata5", "organism": "Mouse", "refseq_name": "transcription factor GATA-5", "refseq_ac": [ { "id": "NP_032119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032119", "type": "external" } ], "gene_names_uniprotkb": "Gata5", "gene_names_refseq": "Gata5", "protein_names_uniprotkb": "Transcription factor GATA-5; GATA-binding factor 5", "protein_names_refseq": "GATA-binding factor 5; Transcription factor GATA-5 (GATA binding factor-5); transcription factor GATA-5", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrial fibrillation (Disease Ontology:DOID:0060224); bicuspid aortic valve disease (Disease Ontology:DOID:0080332); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); tetralogy of Fallot (Disease Ontology:DOID:6419); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:14464); (R-MMU-983231)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "35429678;9119112", "class_list": "", "function": "Endothelial GATA5 positively regulates angiogenesis via cathepsin S-mediated Angpt2/Flk1 and MMP2/9 signaling pathways., [RefSeq, PubMed]; Transcription factor required during cardiovascular development (By similarity). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (PubMed:9119112). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQR0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97489-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05860-1", "uniprot_id": [ { "id": "FMN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05860", "type": "external" } ], "mass": 163581.0, "length": 1466, "protein_name": "Formin-1", "gene_name": "Fmn1", "organism": "Mouse", "refseq_name": "formin-1 isoform 4", "refseq_ac": [ { "id": "NP_001272388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272388", "type": "external" } ], "gene_names_uniprotkb": "Fmn1; Fmn; Ld", "gene_names_refseq": "Fmn1; Fmn; formin-1; ld", "protein_names_uniprotkb": "Formin-1; Limb deformity protein", "protein_names_refseq": "formin-1 isoform 4; limb deformity protein", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (mmu:14260)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1339380;14647292;15198975;16480715;21750661;2392150;34045313;34559979;8516300;9119367", "class_list": "", "function": "Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion., [RefSeq, PubMed]; Plays a role in the formation of adherens junction and the polymerization of linear actin cables., [UniProtKB, PubMed, PubMed]; Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AFY9;A2AFZ0;Q05859", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0072092 ureteric bud invasion;GO:0001822 kidney development;GO:0030036 actin cytoskeleton organization;GO:0051894 positive regulation of focal adhesion assembly;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q05860-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08369-1", "uniprot_id": [ { "id": "GATA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08369", "type": "external" } ], "mass": 44580.0, "length": 441, "protein_name": "Transcription factor GATA-4", "gene_name": "Gata4", "organism": "Mouse", "refseq_name": "transcription factor GATA-4 isoform 2", "refseq_ac": [ { "id": "NP_032118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032118", "type": "external" } ], "gene_names_uniprotkb": "Gata4; Gata-4", "gene_names_refseq": "Gata-4; Gata4", "protein_names_uniprotkb": "Transcription factor GATA-4; GATA-binding factor 4", "protein_names_refseq": "GATA-binding factor 4; transcription factor GATA-4 isoform 2; transcription factor GATA-4", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); atrial heart septal defect 2 (Disease Ontology:DOID:0110107); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:14463); (R-MMU-983231)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "15542826;16199866;17584735;20382855;20485683;21746915;21750661;22215809;23102580;26160456;28487987;33941892;35182466;36852467;40997131;7717974;8083222;8455608;9568714;9584153", "class_list": "", "function": "Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:33941892, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EHF7;P97491;Q9QZK4", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0061026 cardiac muscle tissue regeneration;GO:0003192 mitral valve formation;GO:0003195 tricuspid valve formation;GO:0003290 atrial septum secundum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q08369-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60987-1", "uniprot_id": [ { "id": "FOXG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60987", "type": "external" } ], "mass": 51625.0, "length": 481, "protein_name": "Forkhead box protein G1", "gene_name": "Foxg1", "organism": "Mouse", "refseq_name": "forkhead box protein G1", "refseq_ac": [ { "id": "NP_001153584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153584", "type": "external" } ], "gene_names_uniprotkb": "Foxg1; Fkhl1; Foxg1b; Hfhbf1", "gene_names_refseq": "2900064B05Rik; BF-1; Bf1; Foxg1; Hfh9; Hfhbf1", "protein_names_uniprotkb": "Forkhead box protein G1; BF-1; BF1; Brain factor 1; Forkhead-related protein FKHL1; FoxG1", "protein_names_refseq": "HNF-3/forkhead homolog, brain factor 1; forkhead box protein G1; forkhead-related protein FKHL1", "tax_id": 10090, "disease": "congenital variant of Rett syndrome (Disease Ontology:DOID:0070657); Rett syndrome (Disease Ontology:DOID:1206)", "pathway": " (mmu:15228); (R-MMU-9617828)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16314515;17435750;31219806;40885482;8738140", "class_list": "", "function": "Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80VP3", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016199 axon midline choice point recognition;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q60987-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61575-1", "uniprot_id": [ { "id": "FOXN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61575", "type": "external" } ], "mass": 69245.0, "length": 648, "protein_name": "Forkhead box protein N1", "gene_name": "Foxn1", "organism": "Mouse", "refseq_name": "forkhead box protein N1 isoform 1", "refseq_ac": [ { "id": "NP_032264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032264", "type": "external" } ], "gene_names_uniprotkb": "Foxn1; Fkh19; Hfh11; Whn", "gene_names_refseq": "D11Bhm185e; Fkh19; Foxn1; HFH-11; Hfh11; Whn; nude; nu", "protein_names_uniprotkb": "Forkhead box protein N1; HFH-11; HNF-3/forkhead homolog 11; Hepatocyte nuclear factor 3 forkhead homolog 11; Winged-helix transcription factor nude", "protein_names_refseq": "HNF-3/forkhead homolog 11; forkhead box protein N1 isoform 1; forkhead box protein N1; hepatocyte nuclear factor 3 forkhead homolog 11; winged-helix transcription factor nude", "tax_id": 10090, "disease": "T-cell immunodeficiency, congenital alopecia, and nail dystrophy (Disease Ontology:DOID:0060769); DiGeorge syndrome (Disease Ontology:DOID:11198); Nezelof syndrome (Disease Ontology:DOID:2012); nail disease (Disease Ontology:DOID:4123); primary immunodeficiency disease (Disease Ontology:DOID:612); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:15218)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16232301;17459087;19853842;19955175;21109991;22072979;2288204;23091413;23874334;24184560;7969402;9321431", "class_list": "", "function": "The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs) (PubMed:22072979). Essential for maintenance of mTECs population in the postnatal thymus (PubMed:19955175). Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus (PubMed:21109991). Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age (PubMed:24184560). Essential for the vascularization of the thymus anlage (PubMed:19853842). Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (PubMed:17459087)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0002260 lymphocyte homeostasis;GO:0002360 T cell lineage commitment;GO:0030858 positive regulation of epithelial cell differentiation;GO:1902232 regulation of positive thymic T cell selection", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61575-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61850-1", "uniprot_id": [ { "id": "FOXC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61850", "type": "external" } ], "mass": 52874.0, "length": 494, "protein_name": "Forkhead box protein C2", "gene_name": "Foxc2", "organism": "Mouse", "refseq_name": "forkhead box protein C2", "refseq_ac": [ { "id": "NP_038547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038547", "type": "external" } ], "gene_names_uniprotkb": "Foxc2; Fkh14; Fkhl14; Mfh1", "gene_names_refseq": "Fkh14; Foxc2; Hfhbf3; MFH-1; Mfh1", "protein_names_uniprotkb": "Forkhead box protein C2; BF-3; Brain factor 3; Forkhead-related protein FKHL14; MFH-1 protein; Mesenchyme fork head protein 1; Transcription factor FKH-14", "protein_names_refseq": "BF-3; brain factor 3; forkhead box protein C2; forkhead homolog 14; forkhead-related protein FKHL14; mesenchyme fork head protein 1; transcription factor FKH-14", "tax_id": 10090, "disease": "ptosis (Disease Ontology:DOID:0060260); lymphedema-distichiasis syndrome (Disease Ontology:DOID:0111509); nephritis (Disease Ontology:DOID:10952); lymphedema (Disease Ontology:DOID:4977); eyelid disease (Disease Ontology:DOID:530); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14234)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21183079;24129315;25428506;28135057;28179430;30084848;31219806;34203471;39012257;8325367;8674414;9169153", "class_list": "", "function": "FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton., [RefSeq, PubMed]; Transcriptional activator., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97948;Q63869;Q8C694", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:0035470 positive regulation of vascular wound healing;GO:0048343 paraxial mesodermal cell fate commitment;GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61850-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RKD8-2", "uniprot_id": [ { "id": "FLRT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RKD8", "type": "external" } ], "mass": 74151.0, "length": 674, "protein_name": "Leucine-rich repeat transmembrane protein FLRT1", "gene_name": "Flrt1", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane protein FLRT1 precursor", "refseq_ac": [ { "id": "NP_958813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958813", "type": "external" } ], "gene_names_uniprotkb": "Flrt1", "gene_names_refseq": "D630040I23Rik; Flrt1", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT1; Fibronectin leucine rich transmembrane protein 1", "protein_names_refseq": "leucine-rich repeat transmembrane protein FLRT1 precursor; leucine-rich repeat transmembrane protein FLRT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:396184); (R-MMU-5654687)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16872596;18448090;20421966;21673655;22405201;31599954", "class_list": "", "function": "FLRT1 is expressed at brain compartmental boundaries in embryo, [RefSeq, PubMed]; Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases (PubMed:16872596, PubMed:20421966). Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length (PubMed:20421966). May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3 (PubMed:22405201)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A452J8F8;Q14DT7;Q6RKD9", "ec_number_list": [], "go_molecular_function": "GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007155 cell adhesion;GO:0016358 dendrite development;GO:1990138 neuron projection extension;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6RKD8-2", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPM6-1", "uniprot_id": [ { "id": "FSD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPM6", "type": "external" } ], "mass": 55525.0, "length": 496, "protein_name": "Fibronectin type III and SPRY domain-containing protein 1", "gene_name": "Fsd1", "organism": "Mouse", "refseq_name": "fibronectin type III and SPRY domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_899001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899001", "type": "external" } ], "gene_names_uniprotkb": "Fsd1", "gene_names_refseq": "Fsd1", "protein_names_uniprotkb": "Fibronectin type III and SPRY domain-containing protein 1", "protein_names_refseq": "fibronectin type III and SPRY domain-containing protein 1 isoform 1; fibronectin type III and SPRY domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:240121)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11959962;24129315", "class_list": "", "function": "Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension, [RefSeq, PubMed]; May be involved in microtubule organization and stabilization., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNE6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0032154 cleavage furrow", "go_biological_process": "GO:0051301 cell division;GO:0060236 regulation of mitotic spindle organization;GO:0032465 regulation of cytokinesis;GO:0031122 cytoplasmic microtubule organization;GO:0051302 regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TPM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14719-1", "uniprot_id": [ { "id": "ILRL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P14719", "type": "external" } ], "mass": 64801.0, "length": 567, "protein_name": "Interleukin-1 receptor-like 1", "gene_name": "Il1rl1", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-like 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001020773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020773", "type": "external" } ], "gene_names_uniprotkb": "Il1rl1; Ly84; St2; Ste2", "gene_names_refseq": "DER4; Fit-1; Il1rl1; Ly84; ST2L; St2-rs1; St2; T1/ST2; T1", "protein_names_uniprotkb": "Interleukin-1 receptor-like 1; 3.2.2.6; Interleukin-33 receptor alpha chain; Lymphocyte antigen 84; Protein ST2; Protein T1", "protein_names_refseq": "interleukin-1 receptor-like 1 isoform a precursor; interleukin-33 receptor alpha chain; lymphocyte antigen 84", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); acute asthma (Disease Ontology:DOID:0080810); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); paracoccidioidomycosis (Disease Ontology:DOID:12662); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:17082); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9014843)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "17675517;18003919;1832015;18450470;20200353;21349253;21750661;22660580;2527364;2532153;28930661;29045903;31219806;34644537;35820727;37828378;7916701;8131748", "class_list": "", "function": "Inhibits IL-33 signaling., [UniProtKB, PubMed]; Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:17675517, PubMed:18450470, PubMed:22660580, PubMed:29045903). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function (By similarity). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q05208", "ec_number_list": [ { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0002113 interleukin-33 binding;GO:0002114 interleukin-33 receptor activity;GO:0004908 interleukin-1 receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0043032 positive regulation of macrophage activation;GO:0006954 inflammatory response;GO:0008285 negative regulation of cell population proliferation;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P14719-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CII9-1", "uniprot_id": [ { "id": "CRLF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CII9", "type": "external" } ], "mass": 37762.0, "length": 359, "protein_name": "Cytokine receptor-like factor 2", "gene_name": "Crlf2", "organism": "Mouse", "refseq_name": "cytokine receptor-like factor 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001158207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158207", "type": "external" } ], "gene_names_uniprotkb": "Crlf2; Crlm2; Tpte2; Tslpr", "gene_names_refseq": "CRLM2; Crlf2; Ly114; Tslpr", "protein_names_uniprotkb": "Cytokine receptor-like factor 2; CRLM-2; Cytokine receptor-like molecule 2; TSLP receptor; Thymic stromal lymphopoietin protein receptor; Type I cytokine receptor delta 1", "protein_names_refseq": "TSLP receptor; cytokine receptor-like factor 2 isoform 1 precursor; cytokine receptor-like molecule 2; lymphocyte antigen 114; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin, receptor; type I cytokine receptor delta 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57914)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10733486;10872831;10881176;10974032;11841846;21750661;24632570;31219806;32152506", "class_list": "", "function": "Expression pattern in antigen presenting cells, [RefSeq, PubMed]; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRJ6;Q9JIE7;Q9JIQ7;Q9JJH8;Q9JMD5", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0005125 cytokine activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway;GO:0033005 positive regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CII9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49025-1", "uniprot_id": [ { "id": "CTRO_MOUSE", "url": "https://www.uniprot.org/uniprot/P49025", "type": "external" } ], "mass": 235389.0, "length": 2055, "protein_name": "Citron Rho-interacting kinase", "gene_name": "Cit", "organism": "Mouse", "refseq_name": "citron Rho-interacting kinase isoform X30", "refseq_ac": [ { "id": "XP_006530214", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006530214", "type": "external" } ], "gene_names_uniprotkb": "Cit; Crik", "gene_names_refseq": "C030025P15Rik; CRIK-SK; CRIK; Cit-k; Cit", "protein_names_uniprotkb": "Citron Rho-interacting kinase; 2.7.11.1; CRIK; Rho-interacting, serine/threonine-protein kinase 21", "protein_names_refseq": "citron Rho-interacting kinase isoform X30", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 17 (Disease Ontology:DOID:0070288); primary microcephaly (Disease Ontology:DOID:0070297); traumatic brain injury (Disease Ontology:DOID:0081292); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:12704); (R-MMU-5625900); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013149)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11086988;16452087;18034455;21183079;21750661;22872234;25428506;26495903;30084848;31219806;34203471;34428180;8543060;9697773;9792683", "class_list": "", "function": "Plays a role in cytokinesis. Displays serine/threonine protein kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88528;O88937;O88938;Q3UM99;Q8CIJ1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0016358 dendrite development;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P49025-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99L47-1", "uniprot_id": [ { "id": "F10A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99L47", "type": "external" } ], "mass": 41656.0, "length": 371, "protein_name": "Hsc70-interacting protein", "gene_name": "St13", "organism": "Mouse", "refseq_name": "hsc70-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_598487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598487", "type": "external" } ], "gene_names_uniprotkb": "St13; Fam10a1; Hip", "gene_names_refseq": "1110007I03Rik; 3110002K08Rik; HIP; HOP; HSPABP1; HSPABP; PRO0786; SNC6; St13; p48", "protein_names_uniprotkb": "Hsc70-interacting protein; Hip; Protein FAM10A1; Protein ST13 homolog", "protein_names_refseq": "Hsp70 interacting protein; hsc70-interacting protein isoform 1; hsc70-interacting protein; protein ST13 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70356); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23806337;26495903;26740625;30084848;32152506;35562743;37507081;37828378", "class_list": "", "function": "One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJT4", "ec_number_list": [], "go_molecular_function": "GO:0032564 dATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0009617 response to bacterium;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99L47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20490-1", "uniprot_id": [ { "id": "FCERB_MOUSE", "url": "https://www.uniprot.org/uniprot/P20490", "type": "external" } ], "mass": 25963.0, "length": 235, "protein_name": "High affinity immunoglobulin epsilon receptor subunit beta", "gene_name": "Ms4a2", "organism": "Mouse", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit beta isoform a", "refseq_ac": [ { "id": "NP_038544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038544", "type": "external" } ], "gene_names_uniprotkb": "Ms4a2; Fce1b; Fcer1b; Ms4a1", "gene_names_refseq": "FcRB; Fce1b; Fcer1b; Fcrbeta; Ms4a1; Ms4a2; fcERI", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit beta; Fc epsilon receptor I beta-chain; FcERI; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2", "protein_names_refseq": "Fc receptor, IgE, high affinity I, beta polypeptide; fc epsilon receptor I beta-chain; high affinity immunoglobulin epsilon receptor subunit beta isoform a; high affinity immunoglobulin epsilon receptor subunit beta; membrane-spanning 4-domains, subfamily A, member 1", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:14126); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "16272347;17947660;19001085;21750661;2527850", "class_list": "", "function": "High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy., [UniProtKB, PubMed]; This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019863 IgE binding;GO:0019901 protein kinase binding;GO:0051219 phosphoprotein binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0032998 Fc-epsilon receptor I complex", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043306 positive regulation of mast cell degranulation;GO:0051279 regulation of release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20490-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15105-1", "uniprot_id": [ { "id": "GLNA_MOUSE", "url": "https://www.uniprot.org/uniprot/P15105", "type": "external" } ], "mass": 42120.0, "length": 373, "protein_name": "Glutamine synthetase", "gene_name": "Glul", "organism": "Mouse", "refseq_name": "glutamine synthetase", "refseq_ac": [ { "id": "NP_032157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032157", "type": "external" } ], "gene_names_uniprotkb": "Glul; Glns", "gene_names_refseq": "GS; Glns; Glul", "protein_names_uniprotkb": "Glutamine synthetase; 2.3.1.225; 6.3.1.2; GS; Glutamate--ammonia ligase; Palmitoyltransferase GLUL", "protein_names_refseq": "glutamate decarboxylase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthetase; palmitoyltransferase GLUL", "tax_id": 10090, "disease": "congenital glutamine deficiency (Disease Ontology:DOID:0070544); developmental and epileptic encephalopathy 116 (Disease Ontology:DOID:0070545); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); heart disease (Disease Ontology:DOID:114); Huntington's disease (Disease Ontology:DOID:12858); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); diabetic retinopathy (Disease Ontology:DOID:8947); amino acid metabolic disorder (Disease Ontology:DOID:9252); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14645); (R-MMU-210455); (R-MMU-8964539)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;16323283;17557305;18034455;20107048;21183079;21750661;22645316;22872234;2475638;25605945;25870278;30158707;31178690;33300544;34428180;36031420;36288343;37453647;37507081;39541460;39927985", "class_list": "", "function": "Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:39541460). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (PubMed:25870278). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (PubMed:39541460). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (PubMed:30158707). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (By similarity). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRK7;Q64432;Q91VC6", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0016151 nickel cation binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0001525 angiogenesis;GO:0006536 glutamate metabolic process;GO:0008283 cell population proliferation;GO:0032024 positive regulation of insulin secretion;GO:0051968 positive regulation of synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P15105-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27577-1", "uniprot_id": [ { "id": "ETS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P27577", "type": "external" } ], "mass": 50202.0, "length": 440, "protein_name": "Protein C-ets-1", "gene_name": "Ets1", "organism": "Mouse", "refseq_name": "protein C-ets-1 isoform 1", "refseq_ac": [ { "id": "NP_035938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035938", "type": "external" } ], "gene_names_uniprotkb": "Ets1; Ets-1", "gene_names_refseq": "D230050P06; Ets-1; Ets1; Tpl1; p54; vs", "protein_names_uniprotkb": "Protein C-ets-1; p54", "protein_names_refseq": "E26 avian leukemia oncogene 1, 5' domain; avian erythroblastosis virus E26 oncogene 1; protein C-ets-1 isoform 1; protein C-ets-1; tumor progression locus 1", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:23871); (R-MMU-2559585)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10790365;11779502;15591056;15994560;16862185;17967903;21183079;2163347;21750661;2204020;24897113;25210949;25428506;34428180;38286256;38388532;39162797;8598195;8761310;9566892;9770451", "class_list": "", "function": "ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population., [RefSeq, PubMed]; Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression., [RefSeq, PubMed]; M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor (PubMed:15994560). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (By similarity). May control the differentiation, survival and proliferation of lymphoid cells (By similarity). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61403", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030578 PML body organization;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P27577-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39087-1", "uniprot_id": [ { "id": "GRIK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P39087", "type": "external" } ], "mass": 102486.0, "length": 908, "protein_name": "Glutamate receptor ionotropic, kainate 2", "gene_name": "Grik2", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, kainate 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001104738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104738", "type": "external" } ], "gene_names_uniprotkb": "Grik2; Glur6", "gene_names_refseq": "C130030K03Rik; GluK2; Glur-6; Glur6; Glurbeta2; Grik2", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 2; GluK2; GluR beta-2; GluR-6; GluR6; Glutamate receptor 6; Glutamate receptor beta-2", "protein_names_refseq": "gluR beta-2; glutamate receptor 6; glutamate receptor beta-2; glutamate receptor ionotropic, kainate 2 isoform 1 precursor; glutamate receptor ionotropic, kainate 2; proteasome (prosome, macropain) subunit, alpha type 6 pseudogene", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 6 (Disease Ontology:DOID:0081182); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:14806); (R-MMU-451307); (R-MMU-451308)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12954862;1379666;16452087;17620617;19217376;20007474;21750661;30899004;31474366;33300544;38467901;7681676;8260617;8700852", "class_list": "", "function": "Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (PubMed:31474366)., [UniProtKB, PubMed]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]; The kainate receptor GluK2 mediates cold sensing in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q60933", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0006886 intracellular protein transport;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0048169 regulation of long-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P39087-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TWI9-1", "uniprot_id": [ { "id": "TM63B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TWI9", "type": "external" } ], "mass": 94775.0, "length": 832, "protein_name": "Mechanosensitive cation channel TMEM63B", "gene_name": "Tmem63b", "organism": "Mouse", "refseq_name": "mechanosensitive cation channel TMEM63B isoform 1", "refseq_ac": [ { "id": "NP_937810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937810", "type": "external" } ], "gene_names_uniprotkb": "Tmem63b", "gene_names_refseq": "Tmem63b; mTMEM63B", "protein_names_uniprotkb": "Mechanosensitive cation channel TMEM63B; Transmembrane protein 63B; mTMEM63B", "protein_names_refseq": "CSC1-like protein 2; mechanosensitive cation channel TMEM63B isoform 1; mechanosensitive cation channel TMEM63B", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 118 (Disease Ontology:DOID:0061176); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:224807)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;21750661;22872234;27045885;30382938;31219806;31243992;32375046;33100268;34428180;36496074;37402734;37543036;37945568;38127458;38172113;39217145;39424995;39513891;40107268", "class_list": "", "function": "Brain-specific osmosensitive calcium channel isoform., [UniProtKB, PubMed]; Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:27045885, PubMed:30382938, PubMed:31243992, PubMed:37543036, PubMed:37945568, PubMed:38127458). Osmosensitive cation channel preferentially activated by hypotonic stress (PubMed:27045885). Also acts as a phospholipid scramblase in response to changes in membrane structure: upon changes in membrane curvature and thickness, alters its conformation and translocates phospholipids, such as phosphatidylcholine and sphingomyelin, thereby controlling plasma membrane lipid distribution (PubMed:39217145, PubMed:39424995). Forms a heterodimer with SLC19A2, which mediates phospholipid scramblase activity following Ca(2+) stimulation (PubMed:39217145). Expressed in excitatory neurons of the subfornical organ and functions as a thirst receptor that mediates neuronal response to hyperosmolality to drive thirst and drinking behavior (PubMed:38172113, PubMed:40107268). Facilitates intestinal motility by promoting proliferation of intestinal stem cells (PubMed:39513891). Essential for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Acts as an osmosensor in cochlear outer hair cells (OHCs) where it mediates calcium influx and regulatory volume decrease response (PubMed:32375046). Required for the maintenance of OHC morphology, OHC survival and normal hearing (PubMed:32375046)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCL2;Q6PGA4;Q8C1V5;Q8R0W7", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0017128 phospholipid scramblase activity;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:0140135 mechanosensitive monoatomic cation channel activity;GO:1990760 osmolarity-sensing monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0042756 drinking behavior;GO:0007605 sensory perception of sound;GO:0006887 exocytosis;GO:0036335 intestinal stem cell homeostasis;GO:0160069 surfactant secretion", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q3TWI9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DFZ1-1", "uniprot_id": [ { "id": "GBF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DFZ1", "type": "external" } ], "mass": 206782.0, "length": 1861, "protein_name": "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1", "gene_name": "Gbf1", "organism": "Mouse", "refseq_name": "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1", "refseq_ac": [ { "id": "NP_849261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849261", "type": "external" } ], "gene_names_uniprotkb": "Gbf1", "gene_names_refseq": "1700083E03Rik; Gbf1; mKIAA0248", "protein_names_uniprotkb": "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; BFA-resistant GEF 1", "protein_names_refseq": "BFA-resistant GEF 1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease dominant intermediate A (Disease Ontology:DOID:0110202)", "pathway": " (mmu:107338); (R-MMU-199992); (R-MMU-5620916); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12634853;21750661;25605945;28135057;32333796;32937143", "class_list": "", "function": "Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (By similarity). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (By similarity). Has GEF activity towards ARF1 (By similarity). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (By similarity). Required for the assembly of the Golgi apparatus (By similarity). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (By similarity). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (By similarity). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (By similarity). Plays a role in maintaining mitochondrial morphology (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Novel interaction between p115 and Golgi-specific brefeldin-A-resistant factor 1 (GBF1), [RefSeq, PubMed]; Regulating the regulators: role of phosphorylation in modulating the function of the GBF1/BIG family of Sec7 ARF-GEFs. Review article, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005777 peroxisome;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet", "go_biological_process": "GO:0002263 cell activation involved in immune response;GO:0048205 COPI coating of Golgi vesicle;GO:0061162 establishment of monopolar cell polarity;GO:1903409 reactive oxygen species biosynthetic process;GO:1903420 protein localization to endoplasmic reticulum tubular network", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6DFZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0P3-1", "uniprot_id": [ { "id": "ESTD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0P3", "type": "external" } ], "mass": 31320.0, "length": 282, "protein_name": "S-formylglutathione hydrolase", "gene_name": "Esd", "organism": "Mouse", "refseq_name": "S-formylglutathione hydrolase isoform 2", "refseq_ac": [ { "id": "NP_058599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058599", "type": "external" } ], "gene_names_uniprotkb": "Esd; Es10; Sid478", "gene_names_refseq": "Es-10; Es10; Esd; FGH; sid478", "protein_names_uniprotkb": "S-formylglutathione hydrolase; 3.1.2.12; Esterase 10; Esterase D; FGH; Sid 478", "protein_names_refseq": "S-formylglutathione hydrolase isoform 2; S-formylglutathione hydrolase; Sid 478; esterase 10; esterase D", "tax_id": 10090, "disease": "", "pathway": " (mmu:13885); (R-MMU-156590)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;23806337;37453647;37507081;39927985", "class_list": "glycogene", "function": "Serine hydrolase involved in the detoxification of formaldehyde., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZX4;Q9CWI4", "ec_number_list": [ { "id": "3.1.2.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.12", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding;GO:0052689 carboxylic ester hydrolase activity;GO:0018738 S-formylglutathione hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0046294 formaldehyde catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R0P3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLN5-1", "uniprot_id": [ { "id": "ERMAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLN5", "type": "external" } ], "mass": 63512.0, "length": 566, "protein_name": "Erythroid membrane-associated protein", "gene_name": "Ermap", "organism": "Mouse", "refseq_name": "erythroid membrane-associated protein isoform b precursor", "refseq_ac": [ { "id": "NP_001355995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355995", "type": "external" } ], "gene_names_uniprotkb": "Ermap", "gene_names_refseq": "Ermap", "protein_names_uniprotkb": "Erythroid membrane-associated protein", "protein_names_refseq": "erythroid membrane-associated protein isoform b precursor; erythroid membrane-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:27028)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10721728;21183079;21750661;32620788", "class_list": "", "function": "ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses., [RefSeq, PubMed]; Possible role as a cell-adhesion or receptor molecule of erythroid cells., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV82;Q6P4T5;Q8CEH1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JLN5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97807-1", "uniprot_id": [ { "id": "FUMH_MOUSE", "url": "https://www.uniprot.org/uniprot/P97807", "type": "external" } ], "mass": 54357.0, "length": 507, "protein_name": "Fumarate hydratase, mitochondrial", "gene_name": "Fh1; Fh", "organism": "Mouse", "refseq_name": "fumarate hydratase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_034339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034339", "type": "external" } ], "gene_names_uniprotkb": "Fh1; Fh; Fh1", "gene_names_refseq": "Fh-1; Fh1; Fh", "protein_names_uniprotkb": "Fumarate hydratase, mitochondrial; 4.2.1.2; EF-3; Fumarase", "protein_names_refseq": "EF-3; fumarase; fumarate hydratase, mitochondrial precursor; fumarate hydratase, mitochondrial", "tax_id": 10090, "disease": "fumarase deficiency (Disease Ontology:DOID:0111261); lung non-small cell carcinoma (Disease Ontology:DOID:3908); leiomyomatosis (Disease Ontology:DOID:5138)", "pathway": " (mmu:14194); (R-MMU-71403); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "17418408;21183079;21750661;22014577;23576753;23643539;23806337;25428506;26495903;26740625;28011936;30084848;34428180;37453647;37507081;38615945;39627609;39927985;9032278", "class_list": "", "function": "Catalyzes the dehydration of L-malate to fumarate (PubMed:23643539). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (PubMed:23643539). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (By similarity). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH., [UniProtKB, UniProtKB]; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:23643539). Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable)., [UniProtKB, PubMed]; Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIA9;Q99JL0;Q9DCX0", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0004333 fumarate hydratase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006106 fumarate metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006281 DNA repair;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97807-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13405-1", "uniprot_id": [ { "id": "RB_MOUSE", "url": "https://www.uniprot.org/uniprot/P13405", "type": "external" } ], "mass": 105367.0, "length": 921, "protein_name": "Retinoblastoma-associated protein", "gene_name": "Rb1", "organism": "Mouse", "refseq_name": "retinoblastoma-associated protein", "refseq_ac": [ { "id": "NP_033055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033055", "type": "external" } ], "gene_names_uniprotkb": "Rb1; Rb-1", "gene_names_refseq": "Rb-1; Rb1; Rb; p110-RB1; pRb; pp105", "protein_names_uniprotkb": "Retinoblastoma-associated protein; Rb; p110-RB1; pRb; pp105", "protein_names_refseq": "retinoblastoma 1; retinoblastoma-associated protein", "tax_id": 10090, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); glioblastoma proneural subtype (Disease Ontology:DOID:0050804); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); oligodendroglioma (Disease Ontology:DOID:3181); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); familial retinoblastoma (Disease Ontology:DOID:4648); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); in situ carcinoma (Disease Ontology:DOID:8719); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19645); (R-MMU-113501); (R-MMU-174178); (R-MMU-2299718); (R-MMU-2559584); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69656)", "pathway_count": 9, "publication_count": 19, "publication_id_list": "10526130;10869426;10888886;11571651;12095676;15750587;15983387;16612004;16616919;19564334;20668449;20940255;21183079;21750661;25605945;2671991;34428180;36689330;8336704", "class_list": "", "function": "Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:8336704). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587). Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation (PubMed:16612004). Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity) (PubMed:15750587, PubMed:16612004, PubMed:8336704)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA62", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1903055 positive regulation of extracellular matrix organization;GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0043353 enucleate erythrocyte differentiation;GO:0071459 protein localization to chromosome, centromeric region;GO:1904761 negative regulation of myofibroblast differentiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P13405-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41241-1", "uniprot_id": [ { "id": "CSK_MOUSE", "url": "https://www.uniprot.org/uniprot/P41241", "type": "external" } ], "mass": 50716.0, "length": 450, "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "Csk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase CSK", "refseq_ac": [ { "id": "NP_001291690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291690", "type": "external" } ], "gene_names_uniprotkb": "Csk", "gene_names_refseq": "Csk; p50CSK", "protein_names_uniprotkb": "Tyrosine-protein kinase CSK; 2.7.10.4; C-Src kinase; Protein-tyrosine kinase MPK-2; p50CSK", "protein_names_refseq": "C-Src kinase; protein-tyrosine kinase MPK-2; tyrosine-protein kinase CSK", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:12988); (R-MMU-180292); (R-MMU-202427); (R-MMU-354192); (R-MMU-389948); (R-MMU-5674135); (R-MMU-9013407); (R-MMU-9706369)", "pathway_count": 8, "publication_count": 23, "publication_id_list": "11685249;12218089;12612075;1281307;16129124;16166631;21750661;23526378;26740625;28290451;31219806;31504252;33684096;34428180;36210013;37669828;38753246;7511815;7685657;8890164;8891908;9000135;9858471", "class_list": "", "function": "Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). May act as a negative regulator of EGFR and STAT3 signaling pathways (By similarity)., [UniProtKB, UniProtKB]; STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q03143;Q80WU4;Q8VCW1", "ec_number_list": [ { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P41241-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17679-1", "uniprot_id": [ { "id": "GATA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17679", "type": "external" } ], "mass": 42674.0, "length": 413, "protein_name": "Erythroid transcription factor", "gene_name": "Gata1", "organism": "Mouse", "refseq_name": "erythroid transcription factor", "refseq_ac": [ { "id": "NP_032115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032115", "type": "external" } ], "gene_names_uniprotkb": "Gata1; Gf-1", "gene_names_refseq": "Gata-1; Gata1; Gf-1; eryf1", "protein_names_uniprotkb": "Erythroid transcription factor; Eryf1; GATA-1; GATA-binding factor 1; GF-1; NF-E1 DNA-binding protein", "protein_names_refseq": "GATA-binding factor 1; NF-E1 DNA-binding protein; erythroid transcription factor", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); congenital nonspherocytic hemolytic anemia 9 (Disease Ontology:DOID:0051008); transient myeloproliferative syndrome (Disease Ontology:DOID:0060888); myeloid leukemia associated with Down Syndrome (Disease Ontology:DOID:0080798); X-linked thrombocytopenia with beta-thalassemia (Disease Ontology:DOID:0111767); X-linked dyserythropoietic anemia (Disease Ontology:DOID:0112156); beta thalassemia (Disease Ontology:DOID:12241); lung cancer (Disease Ontology:DOID:1324); major depressive disorder (Disease Ontology:DOID:1470); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myelofibrosis (Disease Ontology:DOID:4971); polycythemia (Disease Ontology:DOID:8432); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14460); (R-MMU-8936459); (R-MMU-8939236); (R-MMU-983231)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10078204;10207073;10212985;15167914;15173587;15920471;15967790;16199866;16391009;16888089;21536911;21555453;21750661;2276623;23717580;24245781;2725678;8206977;8524811", "class_list": "", "function": "Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 35, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIH9;Q7TMX8", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0010724 regulation of definitive erythrocyte differentiation;GO:0035162 embryonic hemopoiesis;GO:0010725 regulation of primitive erythrocyte differentiation;GO:0030221 basophil differentiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P17679-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN98-1", "uniprot_id": [ { "id": "CPEB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN98", "type": "external" } ], "mass": 80122.0, "length": 729, "protein_name": "Cytoplasmic polyadenylation element-binding protein 4", "gene_name": "Cpeb4", "organism": "Mouse", "refseq_name": "cytoplasmic polyadenylation element-binding protein 4 isoform 3", "refseq_ac": [ { "id": "NP_001277607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277607", "type": "external" } ], "gene_names_uniprotkb": "Cpeb4; Kiaa1673", "gene_names_refseq": "Cpe-bp4; Cpeb-4; Cpeb4; mCPEB-4", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 4; CPE-BP4; CPE-binding protein 4; mCPEB-4", "protein_names_refseq": "CPE-binding protein 4; cytoplasmic polyadenylation element-binding protein 4 isoform 3", "tax_id": 10090, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:67579)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12871996;17024188;19144319;21183079;21750661;22138752;24386439;27381259;28092655;30084848;34428180;38284484;38513137;40997131", "class_list": "", "function": "CPEB4 is expressed in the principal cell layers of the hippocampus, [RefSeq, PubMed]; Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf., [RefSeq, PubMed]; Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:17024188). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (By similarity). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (PubMed:28092655). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (By similarity). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (By similarity). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (PubMed:24386439)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6G0;Q69ZD7", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0036294 cellular response to decreased oxygen levels;GO:0002931 response to ischemia;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TN98-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBX0-1", "uniprot_id": [ { "id": "TM63C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBX0", "type": "external" } ], "mass": 93011.0, "length": 802, "protein_name": "Osmosensitive cation channel TMEM63C", "gene_name": "Tmem63c", "organism": "Mouse", "refseq_name": "osmosensitive cation channel TMEM63C isoform 1", "refseq_ac": [ { "id": "NP_766171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766171", "type": "external" } ], "gene_names_uniprotkb": "Tmem63c; CSC1", "gene_names_refseq": "4932420N09; 9330187M14Rik; Tmem63c", "protein_names_uniprotkb": "Osmosensitive cation channel TMEM63C; Calcium permeable stress-gated cation channel 1; Transmembrane protein 63C", "protein_names_refseq": "calcium permeable stress-gated cation channel 1; osmosensitive cation channel TMEM63C isoform 1; osmosensitive cation channel TMEM63C", "tax_id": 10090, "disease": "hereditary spastic paraplegia 87 (Disease Ontology:DOID:0070456); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:217733)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;27045885;32375046;37945568", "class_list": "", "function": "Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:27045885, PubMed:32375046, PubMed:37945568). In contrast to TMEM63B, does not show phospholipid scramblase activity (By similarity). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (By similarity). In particular may regulate mitochondrial motility and function in motor neuron axons (By similarity). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Cryo-EM structure of TMEM63C suggests it functions as a monomer. Publication Status: Online-Only, [RefSeq, PubMed]; TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:1990760 osmolarity-sensing monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006812 monoatomic cation transport;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CBX0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UW59-1", "uniprot_id": [ { "id": "G3UW59_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UW59", "type": "external" } ], "mass": 42294.0, "length": 384, "protein_name": "Ubiquitin-associated protein 1-like", "gene_name": "Ubap1l", "organism": "Mouse", "refseq_name": "ubiquitin-associated protein 1-like isoform 1", "refseq_ac": [ { "id": "NP_001104615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104615", "type": "external" } ], "gene_names_uniprotkb": "Ubap1l", "gene_names_refseq": "Gm514; Ubap1l", "protein_names_uniprotkb": "Ubiquitin-associated protein 1-like", "protein_names_refseq": "ubiquitin-associated protein 1-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208080)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000813 ESCRT I complex", "go_biological_process": "GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UW59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68ED7-1", "uniprot_id": [ { "id": "CRTC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68ED7", "type": "external" } ], "mass": 66945.0, "length": 630, "protein_name": "CREB-regulated transcription coactivator 1", "gene_name": "Crtc1", "organism": "Mouse", "refseq_name": "CREB-regulated transcription coactivator 1 isoform 2", "refseq_ac": [ { "id": "NP_001004062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004062", "type": "external" } ], "gene_names_uniprotkb": "Crtc1; Kiaa0616; Mect1; Torc1", "gene_names_refseq": "Crtc1; Mect1; TORC-1; TORC1; mKIAA0616", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1 homolog; TORC-1; Transducer of CREB protein 1; Transducer of regulated cAMP response element-binding protein 1", "protein_names_refseq": "CREB-regulated transcription coactivator 1 isoform 2; mucoepidermoid carcinoma translocated 1; mucoepidermoid carcinoma translocated protein 1 homolog; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein 1", "tax_id": 10090, "disease": "major depressive disorder (Disease Ontology:DOID:1470); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:382056)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "17360587;21183079;22517741;23699513;23993098;28235073;29211348;29992949;30611118;31219806;31801615;32848054;34678516;36349991;36434056;37196823;40885482", "class_list": "", "function": "CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance., [RefSeq, PubMed]; Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes to islet beta-cell apoptosis and dysfunction., [RefSeq, PubMed]; Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis., [RefSeq, PubMed]; TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus, [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ85", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1902631 negative regulation of membrane hyperpolarization;GO:0006351 DNA-templated transcription;GO:0007613 memory;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q68ED7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQP8-1", "uniprot_id": [ { "id": "CTSRZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQP8", "type": "external" } ], "mass": 22741.0, "length": 194, "protein_name": "Cation channel sperm-associated auxiliary subunit zeta", "gene_name": "Catsperz", "organism": "Mouse", "refseq_name": "cation channel sperm-associated auxiliary subunit zeta", "refseq_ac": [ { "id": "NP_001034583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034583", "type": "external" } ], "gene_names_uniprotkb": "Catsperz; Tex40", "gene_names_refseq": "1700019N12Rik; A430107B04Rik; Catsperz; MLZ-622; Tex40", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit zeta; CatSper-zeta; CatSperzeta; MLZ-622; Protein expressed in male leptotene and zygotene spermatocytes 622; Testis-expressed protein 40", "protein_names_refseq": "catSper-zeta; catSperzeta; cation channel sperm-associated auxiliary subunit zeta; cation channel sperm-associated protein subunit zeta; protein expressed in male leptotene and zygotene spermatocytes 622; testis expressed 40; testis-expressed protein 40; testis-expressed sequence 40 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67077)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20339383;21750661;28226241;31056283;34225353", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:28226241, PubMed:31056283, PubMed:34225353). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:28226241, PubMed:31056283). Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract (PubMed:28226241). Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel (PubMed:31056283)., [UniProtKB, PubMed, PubMed, PubMed]; Targeted disruption of Tex40 (CatSperz) reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAA2;Q9DAP8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005737 cytoplasm;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR35-1", "uniprot_id": [ { "id": "CTRB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR35", "type": "external" } ], "mass": 27822.0, "length": 263, "protein_name": "Chymotrypsinogen B", "gene_name": "Ctrb1", "organism": "Mouse", "refseq_name": "chymotrypsinogen B precursor", "refseq_ac": [ { "id": "NP_079859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079859", "type": "external" } ], "gene_names_uniprotkb": "Ctrb1", "gene_names_refseq": "2200008D09Rik; Ctrb1; Ctrb; Prt-2", "protein_names_uniprotkb": "Chymotrypsinogen B; 3.4.21.1", "protein_names_refseq": "chymotrypsinogen B precursor", "tax_id": 10090, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:66473); (R-MMU-1592389)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;35820727;38981616", "class_list": "", "function": "Secretagogue-induced pancreatitis in mice devoid of chymotrypsin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8X8;Q9DC86", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0034097 response to cytokine;GO:0007586 digestion;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CR35-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7E4-1", "uniprot_id": [ { "id": "CS025_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7E4", "type": "external" } ], "mass": 12112.0, "length": 109, "protein_name": "UPF0449 protein C19orf25 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0449 protein C19orf25 homolog", "refseq_ac": [ { "id": "NP_079797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079797", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "2310011J03Rik", "protein_names_uniprotkb": "UPF0449 protein C19orf25 homolog", "protein_names_refseq": "UPF0449 protein C19orf25 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66374)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15592455;17947660;22872234;25428506;31219806;32848054;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D7E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZM4-1", "uniprot_id": [ { "id": "DNER_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZM4", "type": "external" } ], "mass": 78747.0, "length": 737, "protein_name": "Delta and Notch-like epidermal growth factor-related receptor", "gene_name": "Dner", "organism": "Mouse", "refseq_name": "delta and Notch-like epidermal growth factor-related receptor precursor", "refseq_ac": [ { "id": "NP_690879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690879", "type": "external" } ], "gene_names_uniprotkb": "Dner; Bet; Bret", "gene_names_refseq": "A930026D19Rik; BET; Bret; Dner", "protein_names_uniprotkb": "Delta and Notch-like epidermal growth factor-related receptor; Brain EGF repeat-containing transmembrane protein", "protein_names_refseq": "brain EGF repeat-containing transmembrane protein; delta and Notch-like epidermal growth factor-related receptor precursor; delta and Notch-like epidermal growth factor-related receptor; delta/notch-like EGF-related receptor; transmembrane protein Bet", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:227325)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11950833;11997712;15965470;16298139;18034455;21183079;21750661;30899004;37223028;38553003;40885482", "class_list": "", "function": "DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling., [RefSeq, PubMed]; Expression in developing and mature central nervous system, [RefSeq, PubMed]; Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling., [UniProtKB, PubMed, PubMed]; Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3U697;Q8R226;Q8R4T6;Q8VD97", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0007417 central nervous system development;GO:0048741 skeletal muscle fiber development;GO:0010001 glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8JZM4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VR5-1", "uniprot_id": [ { "id": "DDX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VR5", "type": "external" } ], "mass": 82500.0, "length": 740, "protein_name": "ATP-dependent RNA helicase DDX1", "gene_name": "Ddx1", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX1", "refseq_ac": [ { "id": "NP_598801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598801", "type": "external" } ], "gene_names_uniprotkb": "Ddx1", "gene_names_refseq": "DBP-RB; Ddx1", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX1; 3.6.4.13; DEAD box protein 1", "protein_names_refseq": "ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:104721)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;17322886;18758164;19398953;21183079;21703541;21750661;21952136;22645316;25428506;25428507;29187734;30084848;30295850;31219806;33300544;34388251;34428180;34887587;35778392;37453647;37507081;37828378;38219817;38927017;39627609;39927985;8746565", "class_list": "", "function": "A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation., [RefSeq, PubMed]; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation (By similarity). Acts as a positive transcriptional regulator of cyclin CCND2 expression (PubMed:19398953). Binds to the cyclin CCND2 promoter region (PubMed:19398953). Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. It is also an accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. Cooperates with ZBTB8OS (also known as archease) for the guanylylation of RTCB, a key intermediate step in activation of the tRNA ligase (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (PubMed:21703541)., [UniProtKB, UniProtKB, PubMed, PubMed]; CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1. Publication Status: Online-Only, [RefSeq, PubMed]; DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Publication Status: Online-Only, [RefSeq, PubMed]; The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU41", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q91VR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M87-1", "uniprot_id": [ { "id": "DNJA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M87", "type": "external" } ], "mass": 52443.0, "length": 480, "protein_name": "DnaJ homolog subfamily A member 3, mitochondrial", "gene_name": "Dnaja3", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily A member 3, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001128584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128584", "type": "external" } ], "gene_names_uniprotkb": "Dnaja3; Tid1", "gene_names_refseq": "1200003J13Rik; 1810053A11Rik; Dnaja3; Tid-1; Tid1l", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; Tumorous imaginal discs protein Tid56 homolog; mTid-1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 3; dnaJ homolog subfamily A member 3, mitochondrial isoform 2; dnaJ homolog subfamily A member 3, mitochondrial; dnaJ protein Tid-1; mTid-1; tumorous imaginal discs protein Tid56 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:83945)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11116152;12879007;14993262;19038220;22645316;23576753;31219806;32152506;33300544;34345994;34428180;35820727;36068335;36288343;37453647;37487907;37507081;37828378", "class_list": "", "function": "DNAJA3 regulates B cell development and immune function., [RefSeq, PubMed]; Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse., [RefSeq, PubMed]; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway., [UniProtKB, PubMed]; Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition., [RefSeq, PubMed]; Tid-1S in Th2 cells following activation has a role in induction of apoptosis resistance during the activation of Th2 cells, [RefSeq, PubMed]; Tid1 is critical for early mammalian development, most likely for its function in sustaining embryonic-cell survival, which requires its association with Hsp70., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSM0;Q99L09;Q99P71;Q99P76;Q9CT11;Q9DBJ7;Q9DC44", "ec_number_list": [], "go_molecular_function": "GO:0005133 type II interferon receptor binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007528 neuromuscular junction development;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99M87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI71-1", "uniprot_id": [ { "id": "DLL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI71", "type": "external" } ], "mass": 74991.0, "length": 686, "protein_name": "Delta-like protein 4", "gene_name": "Dll4", "organism": "Mouse", "refseq_name": "delta-like protein 4 precursor", "refseq_ac": [ { "id": "NP_062327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062327", "type": "external" } ], "gene_names_uniprotkb": "Dll4", "gene_names_refseq": "Delta4; Dll4", "protein_names_uniprotkb": "Delta-like protein 4; Delta4; Drosophila Delta homolog 4", "protein_names_refseq": "delta-like 4; delta-like protein 4 precursor; delta-like protein 4; drosophila Delta homolog 4", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); polycystic kidney disease (Disease Ontology:DOID:0080322); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); hemangiopericytoma (Disease Ontology:DOID:264); ischemia (Disease Ontology:DOID:326); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); lung large cell carcinoma (Disease Ontology:DOID:4556); hemangioblastoma (Disease Ontology:DOID:5241); lung small cell carcinoma (Disease Ontology:DOID:5409); varicose veins (Disease Ontology:DOID:799); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:54485); (R-MMU-9013507)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10837024;11134954;22323600", "class_list": "", "function": "Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (PubMed:22323600). During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBU9;Q9JHZ7", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003208 cardiac ventricle morphogenesis;GO:0061074 regulation of neural retina development;GO:0072554 blood vessel lumenization;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JI71-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V2J0-1", "uniprot_id": [ { "id": "CBAR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V2J0", "type": "external" } ], "mass": 33274.0, "length": 292, "protein_name": "CBY1-interacting BAR domain-containing protein 2", "gene_name": "Cibar2", "organism": "Mouse", "refseq_name": "CBY1-interacting BAR domain-containing protein 2", "refseq_ac": [ { "id": "NP_001029152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029152", "type": "external" } ], "gene_names_uniprotkb": "Cibar2; Fam92b", "gene_names_refseq": "1700120B06Rik; Cibar2; Fam92b", "protein_names_uniprotkb": "CBY1-interacting BAR domain-containing protein 2; Protein FAM92B", "protein_names_refseq": "CBY1-interacting BAR domain-containing protein 2; family with sequence similarity 92, member B; protein FAM92B", "tax_id": 10090, "disease": "", "pathway": " (mmu:436062)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;27528616;33300544", "class_list": "", "function": "May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVK4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3V2J0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15037-1", "uniprot_id": [ { "id": "ETS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P15037", "type": "external" } ], "mass": 52827.0, "length": 468, "protein_name": "Protein C-ets-2", "gene_name": "Ets2", "organism": "Mouse", "refseq_name": "protein C-ets-2", "refseq_ac": [ { "id": "NP_035939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035939", "type": "external" } ], "gene_names_uniprotkb": "Ets2", "gene_names_refseq": "Ets-2; Ets2", "protein_names_uniprotkb": "Protein C-ets-2", "protein_names_refseq": "E26 avian leukemia oncogene 2, 3' domain; protein C-ets-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:23872); (R-MMU-2559585)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "11027273;12511603;14612405;15240733;18321244;21183079;21562315;21750661;22128184;25428506;2847145;30084848;31219806;31754329;34428180;36975761;37524226;8437623;8626480;9656143", "class_list": "", "function": "ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation., [RefSeq, PubMed]; ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway., [RefSeq, PubMed]; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P15037-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26323-1", "uniprot_id": [ { "id": "FLI1_MOUSE", "url": "https://www.uniprot.org/uniprot/P26323", "type": "external" } ], "mass": 51002.0, "length": 452, "protein_name": "Friend leukemia integration 1 transcription factor", "gene_name": "Fli1", "organism": "Mouse", "refseq_name": "Friend leukemia integration 1 transcription factor isoform 1", "refseq_ac": [ { "id": "NP_032052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032052", "type": "external" } ], "gene_names_uniprotkb": "Fli1; Fli-1", "gene_names_refseq": "EWSR2; Fli-1; Fli1; SIC-1; Sic1", "protein_names_uniprotkb": "Friend leukemia integration 1 transcription factor; Retroviral integration site protein Fli-1", "protein_names_refseq": "Friend leukemia integration 1 transcription factor isoform 1; friend leukemia integration 1 transcription factor; retroviral integration site protein Fli-1", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:14247)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19470763;2044959;21183079;21750661;24708674;30084848;31219806;34428180;37094946;37790939;8502483", "class_list": "", "function": "Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'., [UniProtKB, UniProtKB]; Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P26323-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47930-1", "uniprot_id": [ { "id": "FOSL2_MOUSE", "url": "https://www.uniprot.org/uniprot/P47930", "type": "external" } ], "mass": 35298.0, "length": 326, "protein_name": "Fos-related antigen 2", "gene_name": "Fosl2", "organism": "Mouse", "refseq_name": "fos-related antigen 2", "refseq_ac": [ { "id": "NP_032063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032063", "type": "external" } ], "gene_names_uniprotkb": "Fosl2; Fra-2; Fra2", "gene_names_refseq": "Fosl2; Fra-2", "protein_names_uniprotkb": "Fos-related antigen 2; FRA-2", "protein_names_refseq": "fos-related antigen 2", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colon adenocarcinoma (Disease Ontology:DOID:234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); renal carcinoma (Disease Ontology:DOID:4451); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:14284)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11948401;18548006;23806337;23807221;25547114;28135057;29272704;31219806;34428180;35820727;38776730;40997131;7936655", "class_list": "", "function": "AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers, [RefSeq, PubMed]; BACH1 transcriptionally upregulates FOSL2 to induce M2 macrophages phenotype by activating TGFbeta/SMAD signaling to promote the transformation of lung fibroblasts into myofibroblasts., [RefSeq, PubMed]; Controls osteoclast survival and size (PubMed:18548006). As a dimer with JUN, activates LIF transcription (PubMed:18548006). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKX7;Q8C231", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0030223 neutrophil differentiation;GO:1901142 insulin metabolic process;GO:0061144 alveolar secondary septum development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47930-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TJZ6-1", "uniprot_id": [ { "id": "FA98A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TJZ6", "type": "external" } ], "mass": 55055.0, "length": 515, "protein_name": "Protein FAM98A", "gene_name": "Fam98a", "organism": "Mouse", "refseq_name": "protein FAM98A isoform 1", "refseq_ac": [ { "id": "NP_598508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598508", "type": "external" } ], "gene_names_uniprotkb": "Fam98a", "gene_names_refseq": "2810405J04Rik; Fam98a", "protein_names_uniprotkb": "Protein FAM98A", "protein_names_refseq": "protein FAM98A isoform 1; protein FAM98A", "tax_id": 10090, "disease": "", "pathway": " (mmu:72722)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "18299400;19224205;20173027;21750661;21952136;22872234;25153642;25428506;26495903;27777970;28011936;30084848;30779550;31219806;34418053;34428180;35820727;37507081;37828378", "class_list": "", "function": "Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis (PubMed:27777970). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99KJ2", "ec_number_list": [], "go_molecular_function": "GO:0008276 protein methyltransferase activity", "go_cellular_component": "GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0006479 protein methylation;GO:0032418 lysosome localization;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q3TJZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQ03-1", "uniprot_id": [ { "id": "FNBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQ03", "type": "external" } ], "mass": 111245.0, "length": 1031, "protein_name": "Formin-binding protein 4", "gene_name": "Fnbp4", "organism": "Mouse", "refseq_name": "formin-binding protein 4 isoform 1", "refseq_ac": [ { "id": "NP_061298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061298", "type": "external" } ], "gene_names_uniprotkb": "Fnbp4; Fbp30; Kiaa1014", "gene_names_refseq": "FBP30; Fnbp30; Fnbp4; mKIAA1014", "protein_names_uniprotkb": "Formin-binding protein 4; Formin-binding protein 30", "protein_names_refseq": "formin binding protein 30; formin-binding protein 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:55935)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10510470;10744724;17242355;19131326;21183079;21750661;23806337;32782141;36852467;40885482;40997131;8605874", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPA6;Q8BNC8;Q9JHC1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6ZQ03-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH70-1", "uniprot_id": [ { "id": "FBXL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH70", "type": "external" } ], "mass": 70269.0, "length": 621, "protein_name": "F-box/LRR-repeat protein 4", "gene_name": "Fbxl4", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 4 isoform 1", "refseq_ac": [ { "id": "NP_766576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766576", "type": "external" } ], "gene_names_uniprotkb": "Fbxl4", "gene_names_refseq": "FBL4; FBL5; Fbxl4", "protein_names_uniprotkb": "F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4", "protein_names_refseq": "F-box/LRR-repeat protein 4 isoform 1; F-box/LRR-repeat protein 4", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 13 (Disease Ontology:DOID:0080131)", "pathway": " (mmu:269514); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;24129315;25428506;30084848;31599954;32525278;36896912;38359748", "class_list": "", "function": "FBXL4 deficiency increases mitochondrial removal by autophagy., [RefSeq, PubMed]; FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a. Erratum:[Redox Biol. 2024 Dec;78:103430. doi: 10.1016/j.redox.2024.103430. PMID: 39578192], [RefSeq, PubMed]; Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors (PubMed:36896912). Also rescues mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (PubMed:38359748)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0016607 nuclear speck;GO:0019005 SCF ubiquitin ligase complex;GO:0005634 nucleus", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0000422 autophagy of mitochondrion;GO:0000423 mitophagy;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BH70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JG2-1", "uniprot_id": [ { "id": "G37L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JG2", "type": "external" } ], "mass": 52729.0, "length": 481, "protein_name": "G protein-coupled receptor 37-like 1", "gene_name": "Gpr37l1", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 37-like 1 precursor", "refseq_ac": [ { "id": "NP_602320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_602320", "type": "external" } ], "gene_names_uniprotkb": "Gpr37l1; Etbrlp2", "gene_names_refseq": "CAG-18; D0Kist8; Gpr37l1", "protein_names_uniprotkb": "G protein-coupled receptor 37-like 1; ETBR-LP-2; Endothelin B receptor-like protein 2", "protein_names_refseq": "ETBR-LP-2; G protein-coupled receptor 37-lke 1; G-protein coupled receptor 37-like 1 precursor; endothelin B receptor-like protein 2; orphan Gpr37-like protein 1; prosaposin receptor GPR37L1", "tax_id": 10090, "disease": "", "pathway": " (mmu:171469); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12679517;17114649;21183079;24062445;25428506;27072655;28688853;28795439;29625592;33300544;37029775;37075680;38530364;38569927", "class_list": "", "function": "Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ., [RefSeq, PubMed]; G protein-coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (PubMed:28795439)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; GPR37L1 controls maturation and organization of cortical astrocytes during development., [RefSeq, PubMed]; Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine. Publication Status: Online-Only, [RefSeq, PubMed]; Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88313;Q80UB9;Q99JG1", "ec_number_list": [], "go_molecular_function": "GO:0036505 prosaposin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0045665 negative regulation of neuron differentiation;GO:0003085 negative regulation of systemic arterial blood pressure;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q99JG2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11862-1", "uniprot_id": [ { "id": "GAS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P11862", "type": "external" } ], "mass": 34901.0, "length": 314, "protein_name": "Growth arrest-specific protein 2", "gene_name": "Gas2", "organism": "Mouse", "refseq_name": "growth arrest-specific protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001317536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317536", "type": "external" } ], "gene_names_uniprotkb": "Gas2; Gas-2", "gene_names_refseq": "Gas-2; Gas2", "protein_names_uniprotkb": "Growth arrest-specific protein 2; GAS-2", "protein_names_refseq": "growth arrest-specific protein 2 isoform 1; growth arrest-specific protein 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 125 (Disease Ontology:DOID:0061124); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:14453); (R-MMU-264870)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10049561;1607387;18630941;21183079;21750661;28990109;33964205;3409319;7489707;8120096", "class_list": "", "function": "Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing., [RefSeq, PubMed]; Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea., [UniProtKB, PubMed]; These findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0016020 membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0001544 initiation of primordial ovarian follicle growth;GO:0006915 apoptotic process;GO:0008360 regulation of cell shape;GO:0051764 actin crosslink formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11862-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFZ4-1", "uniprot_id": [ { "id": "FXL21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFZ4", "type": "external" } ], "mass": 49154.0, "length": 434, "protein_name": "F-box/LRR-repeat protein 21", "gene_name": "Fbxl21", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 21 isoform 2", "refseq_ac": [ { "id": "NP_001333661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333661", "type": "external" } ], "gene_names_uniprotkb": "Fbxl21; Fbl21; Fbxl3b", "gene_names_refseq": "D630045D17Rik; FBL3B; FBXL3B; Fbxl21; Psttm", "protein_names_uniprotkb": "F-box/LRR-repeat protein 21; F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 3B", "protein_names_refseq": "F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 21 isoform 2; F-box/LRR-repeat protein 21; F-box/LRR-repeat protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:213311); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18953409;21750661;23452855;23452856;32937135;36574402", "class_list": "", "function": "FBXL21 plays a dual role: protecting CRY from FBXL3 degradation in the nucleus and promoting CRY degradation within the cytoplasm., [RefSeq, PubMed]; Study shows that FBXL21 ubiquitinates CRY1 and CRY2 and that, surprisingly, FBXL21 stabilizes CRYs. FBXL21 localizes predominantly in the cytosol, whereas FBXL3 is present in the nucleus., [RefSeq, PubMed]; Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities., [UniProtKB, PubMed, PubMed, PubMed]; The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function., [RefSeq, PubMed]; The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSN8;Q8BIJ8;Q8BIW5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0048511 rhythmic process;GO:0043153 entrainment of circadian clock by photoperiod;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BFZ4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZD3-1", "uniprot_id": [ { "id": "GARS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZD3", "type": "external" } ], "mass": 81878.0, "length": 729, "protein_name": "Glycine--tRNA ligase", "gene_name": "Gars1", "organism": "Mouse", "refseq_name": "glycine--tRNA ligase", "refseq_ac": [ { "id": "NP_851009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851009", "type": "external" } ], "gene_names_uniprotkb": "Gars1; Gars", "gene_names_refseq": "GENA202; Gars1; Gars; Gena201; Nmf249; Sgrp23", "protein_names_uniprotkb": "Glycine--tRNA ligase; 2.7.7.-; 6.1.1.14; Ap4A synthetase; Diadenosine tetraphosphate synthetase; GlyRS; Glycyl-tRNA synthetase 1", "protein_names_refseq": "AP-4-A synthetase; ap4A synthetase; diadenosine tetraphosphate synthetase; glyRS; glycine--tRNA ligase; storage granule protein 23", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2D (Disease Ontology:DOID:0110164); autosomal dominant distal hereditary motor neuronopathy 5 (Disease Ontology:DOID:0111203); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); spinal muscular atrophy (Disease Ontology:DOID:12377)", "pathway": " (mmu:353172)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "16982418;17947660;18614015;21183079;21540332;22645316;23806337;24788674;25153642;26503042;26740625;26789244;34428180;34887587;35820727;39627609", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis., [UniProtKB, UniProtKB]; Results indicate that Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) phenotype is caused by novel pathogenic roles for the mutant GARS that specifically affect peripheral neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMM4;Q3UK01;Q8VC67", "ec_number_list": [ { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0004820 glycine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0030424 axon", "go_biological_process": "GO:0015966 diadenosine tetraphosphate biosynthetic process;GO:0006418 tRNA aminoacylation for protein translation;GO:0070150 mitochondrial glycyl-tRNA aminoacylation;GO:0006426 glycyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CZD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGD5-1", "uniprot_id": [ { "id": "CPT1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGD5", "type": "external" } ], "mass": 90030.0, "length": 798, "protein_name": "Palmitoyl thioesterase CPT1C", "gene_name": "Cpt1c", "organism": "Mouse", "refseq_name": "palmitoyl thioesterase CPT1C isoform 1", "refseq_ac": [ { "id": "NP_001239399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239399", "type": "external" } ], "gene_names_uniprotkb": "Cpt1c", "gene_names_refseq": "6530437J22Rik; 9630004I06Rik; CPT I-C; CPT IC; CPT1-B; CPTI-B; Cpt1c", "protein_names_uniprotkb": "Palmitoyl thioesterase CPT1C; 3.1.2.22; CPT I-C; CPTI-B; Carnitine O-palmitoyltransferase 1, brain isoform; Carnitine palmitoyltransferase 1C; Carnitine palmitoyltransferase I", "protein_names_refseq": "carnitine palmitoyltransferase 1, brain; carnitine palmitoyltransferase I; palmitoyl thioesterase CPT1C isoform 1; palmitoyl thioesterase CPT1C", "tax_id": 10090, "disease": "hereditary spastic paraplegia 73 (Disease Ontology:DOID:0110818)", "pathway": " (mmu:78070)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12376098;16651524;17559810;18192268;21750661;22539351;22632720;25428506;25751282;30135643;32848054;32931550;36675212;37309891", "class_list": "", "function": "CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning., [RefSeq, PubMed]; CPT1c is appropriately localized in regions and cell types to regulate energy homeostasis, [RefSeq, PubMed]; CPT1c is necessary for the regulation of energy homeostasis, [RefSeq, PubMed]; Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids. Publication Status: Online-Only, [RefSeq, PubMed]; Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (By similarity). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (PubMed:32931550). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524, PubMed:22539351, PubMed:37309891). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:12376098, PubMed:25751282, PubMed:30135643)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZF8;Q8C071", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009437 carnitine metabolic process;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BGD5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8X9-1", "uniprot_id": [ { "id": "FLTOP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8X9", "type": "external" } ], "mass": 20550.0, "length": 189, "protein_name": "Protein Flattop", "gene_name": "Cfap126", "organism": "Mouse", "refseq_name": "protein Flattop isoform 1", "refseq_ac": [ { "id": "NP_001074744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074744", "type": "external" } ], "gene_names_uniprotkb": "Cfap126; 1700009P17Rik; Fltp", "gene_names_refseq": "1700009P17Rik; Cfap126; Flattop; Fltp", "protein_names_uniprotkb": "Protein Flattop; Cilia- and flagella-associated protein 126", "protein_names_refseq": "UPF0740 protein C1orf192 homolog; protein Flattop isoform 1; protein Flattop", "tax_id": 10090, "disease": "", "pathway": " (mmu:75472)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17971504;21750661;22153975;25296022;37295417;37865089;37989994", "class_list": "", "function": "1700009P17Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Fltp(T2AiCre): a new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The uncharacterized gene Flattop (Fltp) is transcriptionally activated during planar cell polarity acquisition in ciliated tissues. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAJ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016324 apical plasma membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P8X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARZ3-1", "uniprot_id": [ { "id": "FSIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARZ3", "type": "external" } ], "mass": 784857.0, "length": 6995, "protein_name": "Fibrous sheath-interacting protein 2", "gene_name": "Fsip2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fsip2", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibrous sheath-interacting protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 34 (Disease Ontology:DOID:0111911)", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "12606363;21183079;21750661;25605945;29562282;30137358;31219806;34105348;34418053;34428180;35820727", "class_list": "", "function": "Plays a role in spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2ARZ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005739 mitochondrion;GO:0031514 motile cilium;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0061512 protein localization to cilium;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "A2ARZ3-1", "record_type": "protein", "filter_code": "0000000.1000110.000010.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26043-1", "uniprot_id": [ { "id": "RADI_MOUSE", "url": "https://www.uniprot.org/uniprot/P26043", "type": "external" } ], "mass": 68543.0, "length": 583, "protein_name": "Radixin", "gene_name": "Rdx", "organism": "Mouse", "refseq_name": "radixin isoform a", "refseq_ac": [ { "id": "NP_001098086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098086", "type": "external" } ], "gene_names_uniprotkb": "Rdx", "gene_names_refseq": "Rdx", "protein_names_uniprotkb": "Radixin; ESP10", "protein_names_refseq": "ESP10; radixin isoform a", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 24 (Disease Ontology:DOID:0110482); Dubin-Johnson syndrome (Disease Ontology:DOID:12308)", "pathway": " (mmu:19684); (R-MMU-437239)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10970839;12522145;12554651;15913605;16582480;16615918;17459884;18614175;1955455;21750661;23806337;24285636;25428506;25891999;26495903;26740625;30159668;32152506;34428180;36288343;37453647;37507081;37828378;39927985;8479753;9456324;9472040", "class_list": "", "function": "Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS85;Q9QW27", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0051117 ATPase binding;GO:0050839 cell adhesion molecule binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0032487 regulation of Rap protein signal transduction;GO:0030033 microvillus assembly;GO:0061028 establishment of endothelial barrier;GO:1902115 regulation of organelle assembly", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P26043-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42232-1", "uniprot_id": [ { "id": "STA5B_MOUSE", "url": "https://www.uniprot.org/uniprot/P42232", "type": "external" } ], "mass": 90002.0, "length": 786, "protein_name": "Signal transducer and activator of transcription 5B", "gene_name": "Stat5b", "organism": "Mouse", "refseq_name": "signal transducer and activator of transcription 5B", "refseq_ac": [ { "id": "NP_001107035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107035", "type": "external" } ], "gene_names_uniprotkb": "Stat5b", "gene_names_refseq": "Stat5b", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5B", "protein_names_refseq": "mammary gland factor STAT5B; signal transducer and activator of transcription 5B", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); growth hormone insensitivity syndrome with immune dysregulation 1 (Disease Ontology:DOID:0080836); growth hormone insensitivity syndrome with immune dysregulation 2 (Disease Ontology:DOID:0080837); colon adenocarcinoma (Disease Ontology:DOID:234); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20851); (R-MMU-1266695); (R-MMU-1433557); (R-MMU-186763); (R-MMU-512988); (R-MMU-8854691); (R-MMU-8983432); (R-MMU-8985947); (R-MMU-9020558); (R-MMU-9020958); (R-MMU-982772)", "pathway_count": 11, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10835485;11090077;11161808;11773439;14701862;20639532;21135090;21183079;21262971;26495903;28011936;28100634;28528544;30899004;31219806;34428180;39627609;39927985;7568026;7720707;9428692;9528750", "class_list": "", "function": "Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A5D5;Q541Q5;Q60804;Q8K3Q1;Q9JKM1;Q9R0X8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0046543 development of secondary female sexual characteristics;GO:0070669 response to interleukin-2;GO:0046544 development of secondary male sexual characteristics;GO:0097531 mast cell migration", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P42232-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63254-1", "uniprot_id": [ { "id": "CRIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63254", "type": "external" } ], "mass": 8550.0, "length": 77, "protein_name": "Cysteine-rich protein 1", "gene_name": "Crip1", "organism": "Mouse", "refseq_name": "cysteine-rich protein 1", "refseq_ac": [ { "id": "NP_031789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031789", "type": "external" } ], "gene_names_uniprotkb": "Crip1; Crip", "gene_names_refseq": "CRHP; CRP1; Crip1; Crip", "protein_names_uniprotkb": "Cysteine-rich protein 1; CRIP; CRP-1; Cysteine-rich intestinal protein", "protein_names_refseq": "CRP-1; cysteine-rich intestinal protein; cysteine-rich protein 1 (intestinal); cysteine-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12925)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12370427;21750661;23806337;24129315;3085096;31219806", "class_list": "", "function": "Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04006;Q3THF0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042277 peptide binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0010043 response to zinc ion;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010468 regulation of gene expression;GO:0071236 cellular response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63254-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCT8-1", "uniprot_id": [ { "id": "CRIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCT8", "type": "external" } ], "mass": 22727.0, "length": 208, "protein_name": "Cysteine-rich protein 2", "gene_name": "Crip2", "organism": "Mouse", "refseq_name": "cysteine-rich protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001334372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334372", "type": "external" } ], "gene_names_uniprotkb": "Crip2; Crp2; Hlp", "gene_names_refseq": "0610010I23Rik; CRP2; CRP4; Crip2; Crp; ESP1; Hlp", "protein_names_uniprotkb": "Cysteine-rich protein 2; CRP-2; Heart LIM protein", "protein_names_refseq": "CRP-2; LIM only protein HLP; cysteine-rich protein 2 isoform 2; heart LIM protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68337)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12128222;12370427;12839623;15713747;21750661;22517741;22645316;23806337;26192747;26495903;29662084;31219806;32848054;34428180;35820727;36288343;37507081;40021952;40885482", "class_list": "", "function": "HOXA9 inhibits HIF1A-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development. Publication Status: Online-Only, [RefSeq, PubMed]; Observed characteristics of the LIM domain-containing adaptor protein CRIP2 are consistent with a potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton, [RefSeq, PubMed]; Role for the two LIM-domain gene Hlp in the very earliest stages of heart differentiation and development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005938 cell cortex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9DCT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07563-1", "uniprot_id": [ { "id": "COHA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07563", "type": "external" } ], "mass": 147975.0, "length": 1470, "protein_name": "Collagen alpha-1(XVII) chain", "gene_name": "Col17a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XVII) chain isoform 1", "refseq_ac": [ { "id": "NP_001277754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277754", "type": "external" } ], "gene_names_uniprotkb": "Col17a1; Bp180; Bpag2", "gene_names_refseq": "BP180; Bpag2; Bpag; Col17a1", "protein_names_uniprotkb": "Collagen alpha-1(XVII) chain; 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2", "protein_names_refseq": "180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2; collagen alpha-1(XVII) chain isoform 1; collagen alpha-1(XVII) chain; procollagen, type XVII, alpha 1", "tax_id": 10090, "disease": "junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); epithelial recurrent erosion dystrophy (Disease Ontology:DOID:0070337); junctional epidermolysis bullosa (Disease Ontology:DOID:3209)", "pathway": " (mmu:12821); (R-MMU-1650814); (R-MMU-198933); (R-MMU-446107); (R-MMU-8948216)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "34428180;35820727;38175757;38768778;8473327", "class_list": "", "function": "Collagen 17A1 in the Urothelium Regulates Epithelial Cell Integrity and Local Immunologic Responses in Obstructive Uropathy., [RefSeq, PubMed]; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane., [UniProtKB]; NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1., [RefSeq, PubMed]; The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q08AT3;Q3UXX1;Q99LK8", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0030056 hemidesmosome", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0031581 hemidesmosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07563-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W49-1", "uniprot_id": [ { "id": "CRBG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W49", "type": "external" } ], "mass": 114262.0, "length": 1005, "protein_name": "Beta/gamma crystallin domain-containing protein 3", "gene_name": "Crybg3", "organism": "Mouse", "refseq_name": "beta/gamma crystallin domain-containing protein 3", "refseq_ac": [ { "id": "NP_777273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777273", "type": "external" } ], "gene_names_uniprotkb": "Crybg3", "gene_names_refseq": "5031404N19; Crybg3; Gm9581", "protein_names_uniprotkb": "Beta/gamma crystallin domain-containing protein 3", "protein_names_refseq": "beta/gamma crystallin domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:224273)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;23043265;30084848;31219806;37507081", "class_list": "glycogene", "function": "The crystal structure determined at 1.86 A demonstrates that the beta-gamma crystallin domain of Crybg3 resembles more closely the lens beta-gamma crystallins than the microbial crystallins do., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRS6;Q8BMQ9", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0051018 protein kinase A binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80W49-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35689-1", "uniprot_id": [ { "id": "ERCC5_MOUSE", "url": "https://www.uniprot.org/uniprot/P35689", "type": "external" } ], "mass": 130715.0, "length": 1170, "protein_name": "DNA excision repair protein ERCC-5", "gene_name": "Ercc5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ercc5; Ercc-5; Xpg", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA excision repair protein ERCC-5; 3.1.-.-; DNA repair protein complementing XP-G cells homolog; Xeroderma pigmentosum group G-complementing protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "disease by infectious agent (Disease Ontology:DOID:0050117); cerebrooculofacioskeletal syndrome 3 (Disease Ontology:DOID:0080913); xeroderma pigmentosum group G (Disease Ontology:DOID:0110849); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); larynx cancer (Disease Ontology:DOID:2596); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:22592); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6782135)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;25428506;34203471;34428180;7510366;7590748;8703115", "class_list": "", "function": "Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble. Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA. Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II. Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity. Required for DNA replication fork maintenance and preservation of genomic stability. Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site. During HRR, binds to the replication fork with high specificity and stabilizes it. Also, acts upstream of HRR, to promote the release of BRCA1 from DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61528;Q64248", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0043066 negative regulation of apoptotic process;GO:0035264 multicellular organism growth;GO:0009411 response to UV;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35689-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03145-1", "uniprot_id": [ { "id": "EPHA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03145", "type": "external" } ], "mass": 108852.0, "length": 977, "protein_name": "Ephrin type-A receptor 2", "gene_name": "Epha2", "organism": "Mouse", "refseq_name": "ephrin type-A receptor 2 precursor", "refseq_ac": [ { "id": "NP_034269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034269", "type": "external" } ], "gene_names_uniprotkb": "Epha2; Eck; Myk2; Sek2", "gene_names_refseq": "Eck; Epha2; Myk2; Sek-2; Sek2", "protein_names_uniprotkb": "Ephrin type-A receptor 2; 2.7.10.1; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2", "protein_names_refseq": "ephrin type-A receptor 2 precursor; ephrin type-A receptor 2; epithelial cell kinase; tyrosine-protein kinase receptor ECK; tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2", "tax_id": 10090, "disease": "cataract 6 multiple types (Disease Ontology:DOID:0110229)", "pathway": " (mmu:13836); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 13, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;11287184;1281307;15054110;15563374;16782872;16849550;16977320;18387945;18948590;19131326;19299512;19321667;19349973;19656770;20100865;27446912;27802388;29749928;30084848;31219806;32170114;34428180;36380015;37828378;7543898;7918100;7947319;8183555", "class_list": "", "function": "Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells (PubMed:29749928). Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNI2;Q60633;Q62212", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0030054 cell junction", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0030316 osteoclast differentiation;GO:0048570 notochord morphogenesis;GO:0046058 cAMP metabolic process;GO:0060035 notochord cell development", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q03145-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42128-1", "uniprot_id": [ { "id": "FOXK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P42128", "type": "external" } ], "mass": 74920.0, "length": 719, "protein_name": "Forkhead box protein K1", "gene_name": "Foxk1", "organism": "Mouse", "refseq_name": "forkhead box protein K1", "refseq_ac": [ { "id": "NP_951031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_951031", "type": "external" } ], "gene_names_uniprotkb": "Foxk1; Mnf", "gene_names_refseq": "A630048H08Rik; Foxk1; Gm10868; Mnf", "protein_names_uniprotkb": "Forkhead box protein K1; MNF; Myocyte nuclear factor", "protein_names_refseq": "forkhead box protein K1; myocyte nuclear factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17425); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 42, "publication_id_list": "10.1101/2023.09.13.557529;10620510;10792059;12446708;12449423;16376864;17242355;17363903;20013826;21183079;21750661;22476904;22517741;22956541;23714736;24129315;25402684;25428506;25605945;29187734;29861159;30016717;30084848;30700909;30779550;31599954;32747411;32782141;32848054;34428180;34678516;34887587;35822049;36210013;36852467;37889840;38782893;40021952;40885482;40997131;8007964;9271401", "class_list": "", "function": "Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism. Erratum:[FASEB J. 2024 Dec 13;38(24):e70278. doi: 10.1096/fj.202403275. PMID: 39720863], [RefSeq, PubMed]; Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (PubMed:29861159). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (PubMed:12446708, PubMed:22956541, PubMed:8007964, PubMed:9271401). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (PubMed:8007964, PubMed:9271401). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (PubMed:12446708, PubMed:22956541). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (PubMed:22956541, PubMed:9271401). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (PubMed:10792059). Represses myogenic differentiation by inhibiting MEFC activity (PubMed:22956541). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (By similarity). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (By similarity). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:32747411)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "O35939;Q3UHI6;Q3UN67", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042594 response to starvation;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P42128-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFK8-1", "uniprot_id": [ { "id": "FRMD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFK8", "type": "external" } ], "mass": 51828.0, "length": 466, "protein_name": "FERM domain-containing protein 8", "gene_name": "Frmd8", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 8", "refseq_ac": [ { "id": "NP_080445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080445", "type": "external" } ], "gene_names_uniprotkb": "Frmd8", "gene_names_refseq": "1200004M23Rik; 2310035N23Rik; 4931429L16Rik; Frmd8; iTAP", "protein_names_uniprotkb": "FERM domain-containing protein 8; iRhom tail-associated protein; iTAP", "protein_names_refseq": "FERM domain-containing protein 8; iRhom tail-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67457)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19144319;21183079;21750661;25428506;29776906;29897333;29897336;30084848;36720499;37527040", "class_list": "", "function": "FRMD8 promotes inflammatory and growth factor signaling by stabilizing the iRhom2/ADAM17 sheddase complex. Publication Status: Online-Only, [RefSeq, PubMed]; FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth., [RefSeq, PubMed]; ITAP (FRMD8) is a novel iRhom2 interactor that controls TNF-alpha secretion by policing the stability of iRhom2/ADAM17 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results suggest that blood entering the joint activates the iRhom2/ADAM17/TNF-alpha pathway, thereby contributing to osteopenia and synovitis in mice., [RefSeq, PubMed]; The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7U3;Q8C7U5;Q99KB3;Q9CSY6;Q9DC30", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UFK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61660-1", "uniprot_id": [ { "id": "FOXJ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61660", "type": "external" } ], "mass": 45474.0, "length": 421, "protein_name": "Forkhead box protein J1", "gene_name": "Foxj1", "organism": "Mouse", "refseq_name": "forkhead box protein J1", "refseq_ac": [ { "id": "NP_032266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032266", "type": "external" } ], "gene_names_uniprotkb": "Foxj1; Hfh4", "gene_names_refseq": "FKHL-13; Foxj1; HFH-4; Hfh4", "protein_names_uniprotkb": "Forkhead box protein J1; HFH-4; Hepatocyte nuclear factor 3 forkhead homolog 4", "protein_names_refseq": "HNF-3/forkhead homolog 4; forkhead box protein J1; forkhead-related protein FKHL13; hepatocyte nuclear factor 3 forkhead homolog 4", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 43 (Disease Ontology:DOID:0111856); congenital heart disease (Disease Ontology:DOID:1682); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:15223)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10873152;14996907;22357932;27914912;27965440;28666954;7683413;9096351;9739041", "class_list": "", "function": "Transcription factor specifically required for the formation of motile cilia (PubMed:10873152, PubMed:14996907, PubMed:22357932, PubMed:27965440, PubMed:9096351, PubMed:9739041). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157 (PubMed:27965440). Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T) (PubMed:9096351). Activates the transcription of a variety of ciliary proteins in the developing brain and lung (PubMed:27914912, PubMed:28666954)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3US42", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0060429 epithelium development;GO:0002508 central tolerance induction;GO:0002635 negative regulation of germinal center formation;GO:0002897 positive regulation of central B cell tolerance induction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61660-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C180-1", "uniprot_id": [ { "id": "FRS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C180", "type": "external" } ], "mass": 56794.0, "length": 508, "protein_name": "Fibroblast growth factor receptor substrate 2", "gene_name": "Frs2", "organism": "Mouse", "refseq_name": "fibroblast growth factor receptor substrate 2 isoform 1", "refseq_ac": [ { "id": "NP_808466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808466", "type": "external" } ], "gene_names_uniprotkb": "Frs2; Frs2a", "gene_names_refseq": "C330018A15Rik; FRS2-alpha; Frs2alpha; Frs2; SNT-1; SNT1", "protein_names_uniprotkb": "Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2-alpha; SNT-1; Suc1-associated neurotrophic factor target 1", "protein_names_refseq": "FGFR substrate 2; FGFR-signaling adaptor SNT; fibroblast growth factor receptor substrate 2 isoform 1; suc1-associated neurotrophic factor target 1", "tax_id": 10090, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:327826); (R-MMU-109704); (R-MMU-1257604); (R-MMU-170968); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654700); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-9028731); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 22, "publication_count": 21, "publication_id_list": "10629055;10851026;11353842;11390647;11433297;11997436;12181353;16887332;17242355;18452557;19131326;19144319;20094046;31669335;32782141;32848054;37421147;40885482;8780727;9182757;9632781", "class_list": "", "function": "Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development., [RefSeq, PubMed]; FRS2alpha-dependent cell fate transition during endocardial cushion morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005168 neurotrophin TRKA receptor binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0001759 organ induction;GO:0050678 regulation of epithelial cell proliferation;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0046619 lens placode formation involved in camera-type eye formation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8C180-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JB6-1", "uniprot_id": [ { "id": "FOXP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JB6", "type": "external" } ], "mass": 47346.0, "length": 429, "protein_name": "Forkhead box protein P3", "gene_name": "Foxp3", "organism": "Mouse", "refseq_name": "forkhead box protein P3", "refseq_ac": [ { "id": "NP_001186276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186276", "type": "external" } ], "gene_names_uniprotkb": "Foxp3", "gene_names_refseq": "Foxp3; JM2; scurfin; sf", "protein_names_uniprotkb": "Forkhead box protein P3; Scurfin", "protein_names_refseq": "forkhead box protein P3; scurfy", "tax_id": 10090, "disease": "Korean hemorrhagic fever (Disease Ontology:DOID:0050200); adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); specific developmental disorder (Disease Ontology:DOID:0060038); graft-versus-host disease (Disease Ontology:DOID:0081267); immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (Disease Ontology:DOID:0090110); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); anogenital venereal wart (Disease Ontology:DOID:11168); chlamydia (Disease Ontology:DOID:11263); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); hypothyroidism (Disease Ontology:DOID:1459); X-linked ichthyosis (Disease Ontology:DOID:1700); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); pulmonary tuberculosis (Disease Ontology:DOID:2957); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); syphilis (Disease Ontology:DOID:4166); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684); infectious mononucleosis (Disease Ontology:DOID:8568); cutaneous leishmaniasis (Disease Ontology:DOID:9111); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20371); (R-MMU-8877330)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11138001;15790681;16769892;17377532;18368049;19117830;19696312;21750661;22312127;22813742;23853094;23973222;23973223;24722479;30664665;37058110", "class_list": "", "function": "The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:22813742). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002677 negative regulation of chronic inflammatory response;GO:0002666 positive regulation of T cell tolerance induction;GO:0032693 negative regulation of interleukin-10 production;GO:0002637 regulation of immunoglobulin production;GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q99JB6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23818-1", "uniprot_id": [ { "id": "GRIA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P23818", "type": "external" } ], "mass": 101569.0, "length": 907, "protein_name": "Glutamate receptor 1", "gene_name": "Gria1", "organism": "Mouse", "refseq_name": "glutamate receptor 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001106796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106796", "type": "external" } ], "gene_names_uniprotkb": "Gria1; Glur1", "gene_names_refseq": "2900051M01Rik; Glr-1; Glr1; GluA1; GluR-A; GluRA; Glur-1; Glur1; Gria1; HIPA1; gluR-K1", "protein_names_uniprotkb": "Glutamate receptor 1; AMPA-selective glutamate receptor 1; GluA1; GluR-1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1", "protein_names_refseq": "AMPA-selective glutamate receptor 1; glutamate receptor 1 isoform 1 precursor; glutamate receptor A; glutamate receptor ionotropic, AMPA 1", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); autosomal dominant intellectual developmental disorder 67 (Disease Ontology:DOID:0061040); autosomal recessive intellectual developmental disorder 76 (Disease Ontology:DOID:0081235); traumatic brain injury (Disease Ontology:DOID:0081292); neurodegenerative disease (Disease Ontology:DOID:1289); hepatic encephalopathy (Disease Ontology:DOID:13413); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); morphine dependence (Disease Ontology:DOID:2560); central nervous system disease (Disease Ontology:DOID:331); schizoaffective disorder (Disease Ontology:DOID:5418); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); hyperhomocysteinemia (Disease Ontology:DOID:9279); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14799); (R-MMU-204005); (R-MMU-399710); (R-MMU-399719); (R-MMU-416993); (R-MMU-438066); (R-MMU-5694530); (R-MMU-8849932)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12839988;16129400;16407208;16606358;1699805;18341993;20152115;21172611;21750661;23524343;23676497;28334377;28642476;30899004;31651360;33300544;33981040;34428180;40885482", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1699805). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 18, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0031698 beta-2 adrenergic receptor binding;GO:0031681 G-protein beta-subunit binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0071242 cellular response to ammonium ion;GO:0071359 cellular response to dsRNA;GO:0090326 positive regulation of locomotion involved in locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P23818-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89100-1", "uniprot_id": [ { "id": "GRAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/O89100", "type": "external" } ], "mass": 36810.0, "length": 322, "protein_name": "GRB2-related adaptor protein 2", "gene_name": "Grap2", "organism": "Mouse", "refseq_name": "GRB2-related adaptor protein 2", "refseq_ac": [ { "id": "NP_001276371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276371", "type": "external" } ], "gene_names_uniprotkb": "Grap2; Gads; Grb2l; Grid; Mona", "gene_names_refseq": "GRAP-2; GRB2L; GRBLG; GRID; Gads; Grap2; GrbX; Grf40; GrpL; Mona; P38", "protein_names_uniprotkb": "GRB2-related adaptor protein 2; Adapter protein GRID; GADS protein; GRB-2-like protein; GRB-2-related monocytic adapter protein; GRB2L; GRBLG; Growth factor receptor-binding protein; Hematopoietic cell-associated adaptor protein GrpL; MONA; Monocytic adapter", "protein_names_refseq": "GRB-2-like protein; GRB-2-related monocytic adapter protein; GRB2-related adaptor protein 2; Grb2-related adaptor downstream of Sch; adapter protein GRID; growth factor receptor-binding protein; hematopoietic cell-associated adaptor protein GrpL; monocytic adapter; monocytic adaptor", "tax_id": 10090, "disease": "hepatitis C (Disease Ontology:DOID:1883)", "pathway": " (mmu:17444); (R-MMU-1433557); (R-MMU-202433); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-389356); (R-MMU-9607240)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "10209041;10820259;14610044;21183079;21750661;25037454;26895103;34428180;9857184;9872323", "class_list": "", "function": "High GADS expression is associated with neoplasms., [RefSeq, PubMed]; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc., [UniProtKB]; The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O89100-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X996-1", "uniprot_id": [ { "id": "G3X996_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X996", "type": "external" } ], "mass": 62247.0, "length": 541, "protein_name": "Zinc finger protein 846", "gene_name": "Zfp846", "organism": "Mouse", "refseq_name": "zinc finger protein 846", "refseq_ac": [ { "id": "NP_766507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766507", "type": "external" } ], "gene_names_uniprotkb": "Zfp846", "gene_names_refseq": "2210010B09Rik; 9130221F13; Zfp846; Znf846", "protein_names_uniprotkb": "Zinc finger protein 846", "protein_names_refseq": "zinc finger protein 846", "tax_id": 10090, "disease": "", "pathway": " (mmu:244721); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May have a role during differentiation processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X996-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGG2-1", "uniprot_id": [ { "id": "GMIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGG2", "type": "external" } ], "mass": 107545.0, "length": 971, "protein_name": "GEM-interacting protein", "gene_name": "Gmip", "organism": "Mouse", "refseq_name": "GEM-interacting protein", "refseq_ac": [ { "id": "NP_932769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932769", "type": "external" } ], "gene_names_uniprotkb": "Gmip", "gene_names_refseq": "5031419I10Rik; Gmip", "protein_names_uniprotkb": "GEM-interacting protein; GMIP", "protein_names_refseq": "GEM-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78816); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "15345747;19144319;21183079;21750661;22517741;24129315;25074242;31219806;32782141;34428180;39627609;40885482", "class_list": "", "function": "Gmip serves as a brake for the RhoA-mediated movement of neuronal somata, highlighting the significance of speed control in the well-organized neuronal migration and the maintenance of neuronal circuits in the postnatal brain. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates, in vitro and in vivo, the GTPase activity of RhoA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9S3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6PGG2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C419-1", "uniprot_id": [ { "id": "MGLYR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C419", "type": "external" } ], "mass": 134426.0, "length": 1200, "protein_name": "Metabotropic glycine receptor", "gene_name": "Gpr158", "organism": "Mouse", "refseq_name": "metabotropic glycine receptor precursor", "refseq_ac": [ { "id": "NP_001004761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004761", "type": "external" } ], "gene_names_uniprotkb": "Gpr158; Kiaa1136", "gene_names_refseq": "5330427M13Rik; Gpr158; mGlyR; mKIAA1136", "protein_names_uniprotkb": "Metabotropic glycine receptor; G protein-coupled receptor 158; mGlyR", "protein_names_refseq": "metabotropic glycine receptor precursor; metabotropic glycine receptor; probable G-protein coupled receptor 158", "tax_id": 10090, "disease": "", "pathway": " (mmu:241263)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;22689652;25792749;28851741;29419376;30282023;30290982;30355501;30546127;30855200;30899004;31311860;31749686;33300544;34203471;36634900;36996198;39383040", "class_list": "", "function": "GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice., [RefSeq, PubMed]; GPR158/179 recruited RGS complexes to the plasma membrane and augmented their ability to regulate GPCR signaling, [RefSeq, PubMed]; Metabotropic receptor for glycine that controls synapse formation and function in the brain (PubMed:29419376, PubMed:31311860, PubMed:31749686, PubMed:36996198). Acts as an atypical G protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins (PubMed:22689652, PubMed:25792749, PubMed:30546127, PubMed:31311860). In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels (By similarity). Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity (By similarity). Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission (PubMed:31311860, PubMed:36996198). Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (PubMed:28851741, PubMed:29419376, PubMed:30546127, PubMed:31311860, PubMed:31749686). Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability (PubMed:31749686). Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4 (PubMed:30290982). In addition to glycine, may also act as a receptor for osteocalcin (Bglap or Bglap2) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (PubMed:28851741, PubMed:30355501)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B1AWY4;Q8CHB0", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008047 enzyme activator activity;GO:0160079 G protein-coupled glycine receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0072659 protein localization to plasma membrane;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q8C419-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923Z0-1", "uniprot_id": [ { "id": "GPC5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923Z0", "type": "external" } ], "mass": 45899.0, "length": 410, "protein_name": "G protein-coupled receptor family C group 5 member B", "gene_name": "Gprc5b", "organism": "Mouse", "refseq_name": "G-protein coupled receptor family C group 5 member B isoform 2 precursor", "refseq_ac": [ { "id": "NP_071865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071865", "type": "external" } ], "gene_names_uniprotkb": "Gprc5b; Raig2", "gene_names_refseq": "Gprc5b; Raig2", "protein_names_uniprotkb": "G protein-coupled receptor family C group 5 member B; RAIG-2; Retinoic acid-induced gene 2 protein", "protein_names_refseq": "G-protein coupled receptor family C group 5 member B isoform 2 precursor; RAIG-2; hypothetical protein, clone 2-63; retinoic acid-induced gene 2 protein", "tax_id": 10090, "disease": "megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315)", "pathway": " (mmu:64297)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17652913;20436672;21183079;21840300;23169819;35033869;35628521", "class_list": "", "function": "G protein-coupled receptor involved in the regulation of cell volume., [UniProtKB, UniProtKB]; GPRC5B activates obesity-associated inflammatory signaling in adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; GPRC5B has important roles for animal behavior controlled by the central nervous system., [RefSeq, PubMed]; GPRC5B is involved in retinoic acid -dependent morphogenesis/angiogenesis and regulation of extracellular matrix synthesis in the murine placenta and yolk sac., [RefSeq, PubMed]; Gprc5b-v2 may play a role during brain maturation and in matured brain, possibly through the regulation of neuronal morphology and protein-protein interaction Publication Status: Online-Only, [RefSeq, PubMed]; Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Publication Status: Online-Only, [RefSeq, PubMed]; The orphan receptor GPRC5B activates pro-inflammatory signaling in the vascular wall via Fyn and NFkappaB., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCV3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007626 locomotory behavior;GO:0010976 positive regulation of neuron projection development;GO:0035556 intracellular signal transduction;GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q923Z0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KB8-1", "uniprot_id": [ { "id": "GLO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KB8", "type": "external" } ], "mass": 34084.0, "length": 309, "protein_name": "Hydroxyacylglutathione hydrolase, mitochondrial", "gene_name": "Hagh", "organism": "Mouse", "refseq_name": "hydroxyacylglutathione hydrolase, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001153098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153098", "type": "external" } ], "gene_names_uniprotkb": "Hagh; Glo2", "gene_names_refseq": "Glo-2; Glo2; Hagh; Rsp29", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase, mitochondrial; 3.1.2.6; Glx II; Glyoxalase II", "protein_names_refseq": "glx II; glyoxalase II; glyoxylase 2; hydroxyacylglutathione hydrolase, mitochondrial isoform 2; hydroxyacylglutathione hydrolase, mitochondrial; round spermatid protein RSP29", "tax_id": 10090, "disease": "", "pathway": " (mmu:14651); (R-MMU-70268)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;23576753;23806337;24252591;31049129;34428180;37453647;37507081", "class_list": "", "function": "Glyoxalase expression prevents against ischemic neuronal cell damage and ameliorates ischemic injury., [RefSeq, PubMed]; Hyperosmotic stress induced AMPK activation, but this was not responsible for its effects on mTOR activity or autophagy induction. Moreover, the decrease in Trx1 and Glo2 induced by hyperosmotic stress was independent of both autophagy and AMPK activation. Publication Status: Online-Only, [RefSeq, PubMed]; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMR4;Q3UCF6;Q8WUR9", "ec_number_list": [ { "id": "3.1.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.6", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99KB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJA9-1", "uniprot_id": [ { "id": "GRASP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJA9", "type": "external" } ], "mass": 42337.0, "length": 392, "protein_name": "General receptor for phosphoinositides 1-associated scaffold protein", "gene_name": "Tamalin", "organism": "Mouse", "refseq_name": "general receptor for phosphoinositides 1-associated scaffold protein", "refseq_ac": [ { "id": "NP_062391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062391", "type": "external" } ], "gene_names_uniprotkb": "Tamalin; Grasp; MNCb-4428", "gene_names_refseq": "Grasp; Tamalin", "protein_names_uniprotkb": "General receptor for phosphoinositides 1-associated scaffold protein; GRP1-associated scaffold protein", "protein_names_refseq": "GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; GRP1-associated scaffold protein; general receptor for phosphoinositides 1-associated scaffold protein", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:56149)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10828067;11850456;12207967;15173175;17114649;21183079;24129315;36362204", "class_list": "", "function": "Caspase cleavage of GRASP-1 occurs in specific brain regions in a time-dependent manner during development and ischemia., [RefSeq, PubMed]; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses., [UniProtKB]; Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. Publication Status: Online-Only, [RefSeq, PubMed]; Tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKL0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJA9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2W9-1", "uniprot_id": [ { "id": "GRIA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2W9", "type": "external" } ], "mass": 100527.0, "length": 888, "protein_name": "Glutamate receptor 3", "gene_name": "Gria3", "organism": "Mouse", "refseq_name": "glutamate receptor 3 isoform a precursor", "refseq_ac": [ { "id": "NP_001268858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268858", "type": "external" } ], "gene_names_uniprotkb": "Gria3; GluA3; Glur3; Kiaa4184", "gene_names_refseq": "2900064I19Rik; GluA3; GluR-C; GluR-K3; Glur-3; Glur3; Gluralpha3; Gria3", "protein_names_uniprotkb": "Glutamate receptor 3; AMPA-selective glutamate receptor 3; GluR-3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3", "protein_names_refseq": "AMPA-selective glutamate receptor 3; glutamate receptor 3 isoform a precursor; glutamate receptor 3; glutamate receptor channel alpha3 subunit", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability 94 (Disease Ontology:DOID:0060823); neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); central nervous system disease (Disease Ontology:DOID:331); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:53623)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11471062;16129400;18034455;20163115;21750661;28103481;30084848;30899004;33300544;33981040;34428180;34678516;40885482", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (PubMed:28103481). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2VDF4;Q5DTJ0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0001540 amyloid-beta binding;GO:0004970 glutamate-gated receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0035249 synaptic transmission, glutamatergic;GO:0001919 regulation of receptor recycling;GO:0051290 protein heterotetramerization;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9Z2W9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23298-1", "uniprot_id": [ { "id": "KPCL_MOUSE", "url": "https://www.uniprot.org/uniprot/P23298", "type": "external" } ], "mass": 77919.0, "length": 683, "protein_name": "Protein kinase C eta type", "gene_name": "Prkch", "organism": "Mouse", "refseq_name": "protein kinase C eta type isoform 2", "refseq_ac": [ { "id": "NP_001300906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300906", "type": "external" } ], "gene_names_uniprotkb": "Prkch; Pkch", "gene_names_refseq": "Pkch; Prkch", "protein_names_uniprotkb": "Protein kinase C eta type; 2.7.11.13; PKC-L; nPKC-eta", "protein_names_refseq": "PKC-L; nPKC-eta; protein kinase C eta type isoform 2; protein kinase C eta type", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:18755); (R-MMU-114508)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11106751;18780722;19144319;21346190;21750661;2266135;25428506;25605945;30084848;34428180", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization., [UniProtKB, PubMed, PubMed, PubMed]; Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2K8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0010744 positive regulation of macrophage derived foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23298-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWA5-1", "uniprot_id": [ { "id": "KLH31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWA5", "type": "external" } ], "mass": 70181.0, "length": 634, "protein_name": "Kelch-like protein 31", "gene_name": "Klhl31", "organism": "Mouse", "refseq_name": "kelch-like protein 31", "refseq_ac": [ { "id": "NP_766513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766513", "type": "external" } ], "gene_names_uniprotkb": "Klhl31; Kbtbd1; Klhl", "gene_names_refseq": "9830147P19Rik; D930047P17Rik; Kbtbd1; Klhl31", "protein_names_uniprotkb": "Kelch-like protein 31; Kelch repeat and BTB domain-containing protein 1; Kelch-like protein KLHL", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 1; kelch repeat and BTB domain-containing protein 1; kelch-like protein 31; kelch-like protein KLHL", "tax_id": 10090, "disease": "centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": " (mmu:244923)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15302408;20668449;21750661;28872460", "class_list": "", "function": "These findings highlight a role for Klhl31 in the maintenance of skeletal muscle structure and provide insight into the mechanisms underlying congenital myopathies., [RefSeq, PubMed]; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148Q5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0001933 negative regulation of protein phosphorylation;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BWA5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88454-1", "uniprot_id": [ { "id": "KCNK4_MOUSE", "url": "https://www.uniprot.org/uniprot/O88454", "type": "external" } ], "mass": 43052.0, "length": 398, "protein_name": "Potassium channel subfamily K member 4", "gene_name": "Kcnk4", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032457", "type": "external" } ], "gene_names_uniprotkb": "Kcnk4; Traak", "gene_names_refseq": "Kcnk4; TRAAKt; TRAAK", "protein_names_uniprotkb": "Potassium channel subfamily K member 4; TRAAK; TWIK-related arachidonic acid-stimulated potassium channel protein", "protein_names_refseq": "TWIK-related arachidonic acid-stimulated potassium channel protein; potassium channel subfamily K member 4 isoform 1 precursor; protein expressed in male leptotene and zygotene spermatocytes 622", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (mmu:16528); (R-MMU-1299503); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10321245;19279663;21750661;27035963;27035965;28839101;9628867", "class_list": "", "function": "Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins, [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, temperature and lipids (PubMed:9628867). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:27035963, PubMed:27035965). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (By similarity) (PubMed:19279663). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0097604 temperature-gated cation channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0033268 node of Ranvier;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0071469 cellular response to alkaline pH;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0071502 cellular response to temperature stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88454-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28867-1", "uniprot_id": [ { "id": "KPCD_MOUSE", "url": "https://www.uniprot.org/uniprot/P28867", "type": "external" } ], "mass": 77547.0, "length": 674, "protein_name": "Protein kinase C delta type", "gene_name": "Prkcd", "organism": "Mouse", "refseq_name": "protein kinase C delta type isoform 2", "refseq_ac": [ { "id": "NP_035233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035233", "type": "external" } ], "gene_names_uniprotkb": "Prkcd; Pkcd", "gene_names_refseq": "D14Ertd420e; PKC[d]; PKCdelta; Pkcd; Prkcd", "protein_names_uniprotkb": "Protein kinase C delta type; 2.7.10.2; 2.7.11.13; SDK1; Sphingosine-dependent protein kinase-1; Tyrosine-protein kinase PRKCD; nPKC-delta", "protein_names_refseq": "nPKC-delta; protein kinase C delta type isoform 2; protein kinase C delta type; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C[d]; tyrosine-protein kinase PRKCD", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); muscular disease (Disease Ontology:DOID:0080000); autoimmune lymphoproliferative syndrome type 3 (Disease Ontology:DOID:0110119); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); restrictive cardiomyopathy (Disease Ontology:DOID:397); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18753); (R-MMU-111465); (R-MMU-111933); (R-MMU-114508); (R-MMU-1250196); (R-MMU-1489509); (R-MMU-2029485); (R-MMU-450520); (R-MMU-5218921); (R-MMU-5607764); (R-MMU-5668599); (R-MMU-6798695); (R-MMU-877300)", "pathway_count": 13, "publication_count": 43, "publication_id_list": "11558579;11976686;11976687;12207561;1765103;17947660;18025218;18034455;18250455;18387943;18652571;1868068;19015273;19131326;19144319;19914197;19917613;19955485;20173027;21183079;22265677;24576946;25428506;25605945;25947062;26157004;26495903;28373608;29505790;30084848;31219806;33932405;33995031;34428180;35409362;37828378;38134280;38743615;7781068;9054438;9692543;9705322;9748166", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as a positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (PubMed:11976686, PubMed:11976687). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (PubMed:19917613). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA (By similarity). In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:18025218). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:22265677). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (PubMed:9705322). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (By similarity). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (By similarity). Phosphorylates SMPD1 which induces SMPD1 secretion (By similarity). Acts as a negative regulator of smoothened signaling by mediating phosphorylation of GLI1, preventing its localization to the nucleus (PubMed:19015273)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis., [RefSeq, PubMed]; Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91V85;Q9Z333", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", 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"2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" 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"external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904385 cellular response to angiotensin;GO:1900163 positive regulation of phospholipid scramblase activity;GO:2000753 positive regulation of glucosylceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P28867-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61423-1", "uniprot_id": [ { "id": "KCNA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61423", "type": "external" } ], "mass": 73470.0, "length": 654, "protein_name": "Potassium voltage-gated channel subfamily A member 4", "gene_name": "Kcna4", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 4", "refseq_ac": [ { "id": "NP_067250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067250", "type": "external" } ], "gene_names_uniprotkb": "Kcna4", "gene_names_refseq": "Kcna4; Kv1.4", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel subunit Kv1.4", "protein_names_refseq": "potassium voltage-gated channel subfamily A member 4; voltage-gated potassium channel subunit Kv1.4", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:16492); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17114649;21183079;22645316;27582084;32247877;33300544;35820727;36872774;8020965", "class_list": "", "function": "Amyloid-beta Protein Precursor Regulates Electrophysiological Properties in the Hippocampus via Altered Kv1.4 Expression and Function in Mice., [RefSeq, PubMed]; Functional role of endogenous Kv1.4 in experimental demyelination., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:8020965). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:8020965). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBF8", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005216 monoatomic ion channel activity;GO:0005267 potassium channel activity;GO:0030955 potassium ion binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61423-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHZ2-1", "uniprot_id": [ { "id": "KCC2D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHZ2", "type": "external" } ], "mass": 56369.0, "length": 499, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit delta", "gene_name": "Camk2d", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2", "refseq_ac": [ { "id": "NP_001020609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020609", "type": "external" } ], "gene_names_uniprotkb": "Camk2d; Kiaa4163", "gene_names_refseq": "2810011D23Rik; 8030469K03Rik; CaMK II; Camk2d; [d]-CaMKII", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit delta; 2.7.11.17; CaM kinase II subunit delta; CaMK-II subunit delta", "protein_names_refseq": "caM kinase II subunit delta; caMK-II subunit delta; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2; calcium/calmodulin-dependent protein kinase type II subunit delta", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); renovascular hypertension (Disease Ontology:DOID:1591); epilepsy (Disease Ontology:DOID:1826); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:108058); (R-MMU-3371571); (R-MMU-399719); (R-MMU-438066); (R-MMU-5578775); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-877300); (R-MMU-936837)", "pathway_count": 9, "publication_count": 24, "publication_id_list": "10967556;11972023;12676814;15456698;15793582;17124532;17242355;19131326;19179290;19381018;20194790;21183079;21750661;22645316;23806337;24052497;25227892;25428506;28662005;33300544;33926209;38229002;38597448;40885482", "class_list": "", "function": "CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport (PubMed:12676814, PubMed:15456698, PubMed:17124532). Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure (PubMed:12676814, PubMed:19179290, PubMed:19381018). Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808' (PubMed:20194790). In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction (PubMed:15793582). In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure (PubMed:17124532). Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKgamma and CaMKdelta against ischemic reperfusion injury in mice]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF87;Q3UQH9;Q5DTK4;Q8CAC5;Q9CZE2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0086003 cardiac muscle cell contraction;GO:1901897 regulation of relaxation of cardiac muscle;GO:0006468 protein phosphorylation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q6PHZ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1S7-1", "uniprot_id": [ { "id": "KREM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1S7", "type": "external" } ], "mass": 49170.0, "length": 461, "protein_name": "Kremen protein 2", "gene_name": "Kremen2", "organism": "Mouse", "refseq_name": "kremen protein 2 precursor", "refseq_ac": [ { "id": "NP_082692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082692", "type": "external" } ], "gene_names_uniprotkb": "Kremen2", "gene_names_refseq": "2900054E04Rik; Kremen2; Krm2", "protein_names_uniprotkb": "Kremen protein 2; Dickkopf receptor 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose", "protein_names_refseq": "dickkopf receptor 2; kremen protein 2 precursor; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose", "tax_id": 10090, "disease": "", "pathway": " (mmu:73016); (R-MMU-3772470)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12050670;16531414;18505822;26206087;31069116;37270563", "class_list": "", "function": "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling., [RefSeq, PubMed]; Kremen2 antagonizes the apoptotic activity of Kremen1 Publication Status: Online-Only, [RefSeq, PubMed]; Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBR6", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0060173 limb development;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1S7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3F6-1", "uniprot_id": [ { "id": "KCNQ3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3F6", "type": "external" } ], "mass": 96852.0, "length": 873, "protein_name": "Potassium voltage-gated channel subfamily KQT member 3", "gene_name": "Kcnq3", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily KQT member 3", "refseq_ac": [ { "id": "NP_690887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690887", "type": "external" } ], "gene_names_uniprotkb": "Kcnq3", "gene_names_refseq": "Kcnq3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 3; KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3", "protein_names_refseq": "KQT-like 3; potassium channel subunit alpha KvLQT3; potassium voltage-gated channel subfamily KQT member 3; voltage-gated potassium channel subunit Kv7.3", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); autistic disorder (Disease Ontology:DOID:12849); benign neonatal seizures (Disease Ontology:DOID:14264); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:110862)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17114649;27979964;34678516;36210013;37607817;38440182", "class_list": "", "function": "KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons., [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (By similarity). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QJY5", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0071242 cellular response to ammonium ion;GO:1903701 substantia propria of cornea development;GO:0098976 excitatory chemical synaptic transmission;GO:0006468 protein phosphorylation;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K3F6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R226-1", "uniprot_id": [ { "id": "KHDR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R226", "type": "external" } ], "mass": 38807.0, "length": 346, "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "gene_name": "Khdrbs3", "organism": "Mouse", "refseq_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform 1", "refseq_ac": [ { "id": "NP_034288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034288", "type": "external" } ], "gene_names_uniprotkb": "Khdrbs3; Salp; Slm2", "gene_names_refseq": "Etle; Khdrbs3; SLM-2; Salp; Slm2; T-STAR", "protein_names_uniprotkb": "KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein Etoile; SLM-2; Sam68-like mammalian protein 2", "protein_names_refseq": "KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform 1; KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein Etoile; etoile; sam68-like mammalian protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13992); (R-MMU-8849468)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10077576;10332027;15163637;15471878;19457263;19916944;21750661;22196734;22645316;23637638;24469635;25505328;27174676;34428180", "class_list": "", "function": "RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro (PubMed:19457263). Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity). Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:15471878). Involved in splice site selection of vascular endothelial growth factor (By similarity). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects (PubMed:22196734, PubMed:23637638, PubMed:24469635, PubMed:27174676). Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense-mediated decay (PubMed:25505328). Can bind FABP9 mRNA (PubMed:19916944). May play a role as a negative regulator of cell growth. Inhibits cell proliferation., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88624", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R226-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG40-1", "uniprot_id": [ { "id": "KTNB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG40", "type": "external" } ], "mass": 72639.0, "length": 658, "protein_name": "Katanin p80 WD40 repeat-containing subunit B1", "gene_name": "Katnb1", "organism": "Mouse", "refseq_name": "katanin p80 WD40 repeat-containing subunit B1", "refseq_ac": [ { "id": "NP_083081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083081", "type": "external" } ], "gene_names_uniprotkb": "Katnb1", "gene_names_refseq": "2410003J24Rik; KAT; Katnb1", "protein_names_uniprotkb": "Katanin p80 WD40 repeat-containing subunit B1; Katanin p80 subunit B1; p80 katanin", "protein_names_refseq": "katanin p80 WD40 repeat-containing subunit B1; katanin p80 subunit B1; p80 katanin", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); lissencephaly 6 (Disease Ontology:DOID:0112236); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:74187)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16203747;19261606;21750661;22872234;25428506;25521379;28436967;30084848;31219806;31353241;34822718;36210013", "class_list": "", "function": "Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal, [RefSeq, PubMed]; KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development., [RefSeq, PubMed]; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth., [UniProtKB, PubMed, HAMAP]; Study uncovered an unexpected role of the p60-MIT and p80-CTD domains of katanin in the oligomerization and regulation of the protein. p80-CTD mediates the assembly of p60-MIT:p80-CTD heterodimers into heterotetramers that have an impact on katanin MT end and lattice binding as well as on the severing activity of the enzyme. The heterotetrameric structure of the p60-MIT:p80-CTD K555A/R591A mutant revealed a domain swap., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CD18;Q8R1J0;Q9CWV2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0046982 protein heterodimerization activity;GO:0070840 dynein complex binding;GO:0060590 ATPase regulator activity", "go_cellular_component": "GO:0008352 katanin complex;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0007079 mitotic chromosome movement towards spindle pole;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:0010976 positive regulation of neuron projection development;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BG40-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AVQ5-1", "uniprot_id": [ { "id": "CMAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AVQ5", "type": "external" } ], "mass": 47584.0, "length": 414, "protein_name": "Ciliary microtubule-associated protein 2", "gene_name": "Cimap2", "organism": "Mouse", "refseq_name": "ciliary microtubule-associated protein 2", "refseq_ac": [ { "id": "NP_899005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899005", "type": "external" } ], "gene_names_uniprotkb": "Cimap2; BC055111; Lem; Lexm", "gene_names_refseq": "Cimap2; Lexm", "protein_names_uniprotkb": "Ciliary microtubule-associated protein 2; Lymphocyte expansion molecule", "protein_names_refseq": "ciliary microtubule-associated protein 2; lymphocyte expansion molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:242602)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25883318", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVQ4;Q7TPM4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AVQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42703-1", "uniprot_id": [ { "id": "LIFR_MOUSE", "url": "https://www.uniprot.org/uniprot/P42703", "type": "external" } ], "mass": 122574.0, "length": 1092, "protein_name": "Leukemia inhibitory factor receptor", "gene_name": "Lifr", "organism": "Mouse", "refseq_name": "leukemia inhibitory factor receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_001106857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106857", "type": "external" } ], "gene_names_uniprotkb": "Lifr", "gene_names_refseq": "A230075M04Rik; LIF; Lifr", "protein_names_uniprotkb": "Leukemia inhibitory factor receptor; D-factor/LIF receptor; LIF receptor; LIF-R", "protein_names_refseq": "D-factor/LIF receptor; LIF-R; leukemia inhibitory factor receptor alpha chain; leukemia inhibitory factor receptor isoform 2 precursor; soluble differentiation-stimulating factor receptor", "tax_id": 10090, "disease": "congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:16880); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;17652170;1915266;19349973;21183079;21750661;30084848;30779550;30899004;31599954;34428180;35820727;36210013;40185397;7901054;8056772", "class_list": "", "function": "Could inhibit the biological activity of LIF by blocking its binding to receptors on target cells., [UniProtKB, PubMed]; Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR. Signal transmission is initiated either by binding directly to cytokines, such as OSM or LIF, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor CNTFR; ligand binding induces heterodimerization of IL6ST/gp130 and LIFR which activates JAK tyrosine kinases bound to their intracellular domains. These kinases subsequently phosphorylate the homodimer or heterodimer form of IL6ST/gp130. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STATs). Engages sites 3 of ligands cytokines., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 14, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 14, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 14, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 11, "disease_count": 2, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0Y2", "ec_number_list": [], "go_molecular_function": "GO:0004923 leukemia inhibitory factor receptor activity;GO:0015026 coreceptor activity;GO:0019838 growth factor binding;GO:0019955 cytokine binding;GO:0004924 oncostatin-M receptor activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038165 oncostatin-M-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0048812 neuron projection morphogenesis;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P42703-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000100011001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLK9-1", "uniprot_id": [ { "id": "KS6C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLK9", "type": "external" } ], "mass": 115712.0, "length": 1056, "protein_name": "Ribosomal protein S6 kinase delta-1", "gene_name": "Rps6kc1", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase delta-1", "refseq_ac": [ { "id": "NP_848890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848890", "type": "external" } ], "gene_names_uniprotkb": "Rps6kc1", "gene_names_refseq": "B130003F20Rik; Rpk118; Rps6kc1", "protein_names_uniprotkb": "Ribosomal protein S6 kinase delta-1; 2.7.11.1; 52 kDa ribosomal protein S6 kinase; S6K-delta-1; SPHK1-binding protein; Sphingosine kinase 1-binding protein", "protein_names_refseq": "52 kDa ribosomal protein S6 kinase; S6K-delta-1; ribosomal protein S6 kinase delta-1; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, 52kDa, polypeptide 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:320119)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19144319;21183079;21750661;31219806", "class_list": "", "function": "May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. Plays a role in the recruitment of PRDX3 to early endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDY3;Q6PDY4;Q8BMQ5;Q8BX49", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BLK9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAP0-1", "uniprot_id": [ { "id": "LRC46_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAP0", "type": "external" } ], "mass": 36048.0, "length": 323, "protein_name": "Leucine-rich repeat-containing protein 46", "gene_name": "Lrrc46", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 46", "refseq_ac": [ { "id": "NP_081302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081302", "type": "external" } ], "gene_names_uniprotkb": "Lrrc46", "gene_names_refseq": "1700006D24Rik; Lrrc46", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 46", "protein_names_refseq": "leucine-rich repeat-containing protein 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:69297)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;35955660;38874710;39245650", "class_list": "", "function": "Identification of LRRC46 as a novel candidate gene for high myopia., [RefSeq, PubMed]; Required for normal spermatogenesis and male fertility. Plays an important role in sperm flagellum biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1Z3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0098727 maintenance of cell number;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAP0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERG0-1", "uniprot_id": [ { "id": "LIMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERG0", "type": "external" } ], "mass": 84060.0, "length": 753, "protein_name": "LIM domain and actin-binding protein 1", "gene_name": "Lima1", "organism": "Mouse", "refseq_name": "LIM domain and actin-binding protein 1 isoform a", "refseq_ac": [ { "id": "NP_001107017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107017", "type": "external" } ], "gene_names_uniprotkb": "Lima1; D15Ertd366e; Eplin", "gene_names_refseq": "Eplin; Lima1", "protein_names_uniprotkb": "LIM domain and actin-binding protein 1; Epithelial protein lost in neoplasm; mEPLIN", "protein_names_refseq": "LIM domain and actin-binding protein 1 isoform a; LIM domain and actin-binding protein 1; epithelial protein lost in neoplasm", "tax_id": 10090, "disease": "", "pathway": " (mmu:65970)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11179679;11950948;17242355;17875928;18093941;18630941;19131326;19144319;20236507;21183079;21750661;23806337;24788674;25153642;25428506;28135057;28528544;29880681;30016717;30084848;30779550;31219806;34428180;34887587;35105859;35820727;36210013;38822260;39921472", "class_list": "", "function": "Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Acts as a negative regulator of primary cilium formation (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (PubMed:29880681)., [UniProtKB, UniProtKB, PubMed]; EPLIN functions to link the cadherin-catenin complex to F-actin and simultaneously stabilizes this population of actin fibers, resulting in the establishment of the adhesion, [RefSeq, PubMed]; EPLIN may function in growth control by associating with and regulating the actin cytoskeleton, [RefSeq, PubMed]; ERK-mediated phosphorylation of EPLIN contributes to actin filament reorganization and enhanced cell motility., [RefSeq, PubMed]; Eplin-alpha transcription is regulated by actin-MAL-SRF signalling. Publication Status: Online-Only, [RefSeq, PubMed]; Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Lipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; This study identifies LIMA1 as a key protein regulating intestinal cholesterol absorption., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2H0;Q9ERG1", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0140778 microtubule stabilizing activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:1902018 negative regulation of cilium assembly;GO:0032233 positive regulation of actin filament bundle assembly;GO:0008203 cholesterol metabolic process;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9ERG0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2U7-1", "uniprot_id": [ { "id": "LRC42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2U7", "type": "external" } ], "mass": 47949.0, "length": 421, "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "Lrrc42", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 42", "refseq_ac": [ { "id": "NP_084261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084261", "type": "external" } ], "gene_names_uniprotkb": "Lrrc42", "gene_names_refseq": "A930011F22Rik; Lrrc42", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 42", "protein_names_refseq": "leucine-rich repeat-containing protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:77809)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;31599954;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE62;Q9CTP9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R2U7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25206-1", "uniprot_id": [ { "id": "MCM3_MOUSE", "url": "https://www.uniprot.org/uniprot/P25206", "type": "external" } ], "mass": 91546.0, "length": 812, "protein_name": "DNA replication licensing factor MCM3", "gene_name": "Mcm3", "organism": "Mouse", "refseq_name": "DNA replication licensing factor MCM3", "refseq_ac": [ { "id": "NP_032589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032589", "type": "external" } ], "gene_names_uniprotkb": "Mcm3; Mcmd3; Mcmd", "gene_names_refseq": "Mcm3; Mcmd; P1-MCM3; P1; p1.m", "protein_names_uniprotkb": "DNA replication licensing factor MCM3; 3.6.4.12; DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3", "protein_names_refseq": "DNA polymerase alpha holoenzyme-associated protein P1; DNA replication licensing factor MCM3; mini chromosome maintenance deficient; minichromosome maintenance deficient 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:17215); (R-MMU-176187); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10733502;1549468;17242355;19131326;21183079;22645316;23806337;24788674;25153642;28528544;31219806;34418053;34428180;34887587;39627609;7925275", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61492", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:0006279 premeiotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P25206-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU85-1", "uniprot_id": [ { "id": "MSRB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU85", "type": "external" } ], "mass": 26832.0, "length": 253, "protein_name": "Methionine-R-sulfoxide reductase B3, mitochondrial", "gene_name": "Msrb3", "organism": "Mouse", "refseq_name": "methionine-R-sulfoxide reductase B3, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_796066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796066", "type": "external" } ], "gene_names_uniprotkb": "Msrb3", "gene_names_refseq": "D430026P16Rik; I-8-23; MsrB2; Msrb3", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B3, mitochondrial; 1.8.4.12; 1.8.4.14; MsrB3", "protein_names_refseq": "methionine-R-sulfoxide reductase B3, mitochondrial isoform 1; methionine-R-sulfoxide reductase B3, mitochondrial", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 74 (Disease Ontology:DOID:0110523)", "pathway": " (mmu:320183); (R-MMU-5676934)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15249228;21183079;21185009;21750661;23806337;24191262;24583268;25153642;26649646;28135057;32908641", "class_list": "", "function": "Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine., [UniProtKB, UniProtKB]; Data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency., [RefSeq, PubMed]; Data suggest that, in mice, MsrB3 is largely or exclusively an endoplasmic reticulum-resident protein, and that the reduction of methionine-R-sulfoxides in different cellular compartments is provided by individual MsrB isozymes. [MsrB3], [RefSeq, PubMed]; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues., [UniProtKB, UniProtKB]; MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3. Publication Status: Online-Only, [RefSeq, PubMed]; MsrB3 deficiency activates the cell cycle inhibitors p21 and p27., [RefSeq, PubMed]; Results provide insight into the role of MsrB3 in hearing function and bring us one step closer to hearing restoration as a fundamental therapy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BU85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54972-1", "uniprot_id": [ { "id": "MTG16_MOUSE", "url": "https://www.uniprot.org/uniprot/O54972", "type": "external" } ], "mass": 68032.0, "length": 620, "protein_name": "Transcriptional corepressor CBFA2T3", "gene_name": "Cbfa2t3", "organism": "Mouse", "refseq_name": "transcriptional corepressor CBFA2T3 isoform 2", "refseq_ac": [ { "id": "NP_001103343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103343", "type": "external" } ], "gene_names_uniprotkb": "Cbfa2t3; Cbfa2t3h; Mtgr2", "gene_names_refseq": "A630044F12Rik; Cbfa2t3h; Cbfa2t3; ETO-2; Eto2; MTGR2", "protein_names_uniprotkb": "Transcriptional corepressor CBFA2T3; Eight twenty one protein 2; MTG8-related protein 2; Protein ETO-2", "protein_names_refseq": "ETO/MTG8-related protein ETO-2; MTG8-related protein 2; eight twenty one protein 2; myeloid translocation gene-related protein 2; protein CBFA2T3; transcriptional corepressor CBFA2T3 isoform 2; transcriptional corepressor CBFA2T3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12398)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10022820;11533236;15231665;16287841;16407974;17533052;21750661;34428180;38786053", "class_list": "", "function": "Association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation, [RefSeq, PubMed]; CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid Accumulation in Mouse Liver. Publication Status: Online-Only, [RefSeq, PubMed]; The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation., [RefSeq, PubMed]; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974). Plays a role in granulocyte differentiation (PubMed:15231665)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TND6;Q8BZS0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54972-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYA6-1", "uniprot_id": [ { "id": "MPP8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYA6", "type": "external" } ], "mass": 97467.0, "length": 858, "protein_name": "M-phase phosphoprotein 8", "gene_name": "Mphosph8", "organism": "Mouse", "refseq_name": "M-phase phosphoprotein 8 isoform 1", "refseq_ac": [ { "id": "NP_076262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076262", "type": "external" } ], "gene_names_uniprotkb": "Mphosph8; Mpp8", "gene_names_refseq": "1500035L22Rik; 4930548G07Rik; Mphosph8", "protein_names_uniprotkb": "M-phase phosphoprotein 8", "protein_names_refseq": "M-phase phosphoprotein 8 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75339)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17242355;21183079;23416073;25428506;30084848;30779550;31112734;31219806;34428180;35820727;36332029;37626833", "class_list": "", "function": "Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (By similarity). As part of the HUSH complex, promotes epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements: the HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (By similarity). MPHOSPH8 mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes (By similarity). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (By similarity). Mediates silencing of E-cadherin (CDH1) and protocadherin genes in the nervous system (PubMed:36332029)., [UniProtKB, UniProtKB, PubMed]; MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H600;Q3TWY7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0032480 negative regulation of type I interferon production;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0140719 constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3TYA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZR2-1", "uniprot_id": [ { "id": "MSD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZR2", "type": "external" } ], "mass": 61361.0, "length": 559, "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 2", "gene_name": "Msantd2", "organism": "Mouse", "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 2", "refseq_ac": [ { "id": "NP_666334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666334", "type": "external" } ], "gene_names_uniprotkb": "Msantd2", "gene_names_refseq": "2810450G17Rik; 9530092B10Rik; Msantd2", "protein_names_uniprotkb": "Myb/SANT-like DNA-binding domain-containing protein 2", "protein_names_refseq": "myb/SANT-like DNA-binding domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235184)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;25428506;30084848;30779550;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3V3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6NZR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UL01-1", "uniprot_id": [ { "id": "MORN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6UL01", "type": "external" } ], "mass": 8897.0, "length": 79, "protein_name": "MORN repeat-containing protein 2", "gene_name": "Morn2", "organism": "Mouse", "refseq_name": "MORN repeat-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001347369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001347369", "type": "external" } ], "gene_names_uniprotkb": "Morn2; Mopt", "gene_names_refseq": "Mopt; Morn2", "protein_names_uniprotkb": "MORN repeat-containing protein 2; MORN motif protein in testis", "protein_names_refseq": "MORN motif protein in testis; MORN repeat-containing protein 2 isoform 2; MORN repeat-containing protein 2; protein containing single MORN motif in testis", "tax_id": 10090, "disease": "", "pathway": " (mmu:378462)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19913896;21750661;32414768;38443933;40473901", "class_list": "", "function": "Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis., [RefSeq, PubMed]; MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Might have a role in spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6UL01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3P7-1", "uniprot_id": [ { "id": "MTA70_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3P7", "type": "external" } ], "mass": 64616.0, "length": 580, "protein_name": "N(6)-adenosine-methyltransferase catalytic subunit METTL3", "gene_name": "Mettl3", "organism": "Mouse", "refseq_name": "N(6)-adenosine-methyltransferase catalytic subunit METTL3", "refseq_ac": [ { "id": "NP_062695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062695", "type": "external" } ], "gene_names_uniprotkb": "Mettl3; Mta70", "gene_names_refseq": "2310024F18Rik; M6A; Mettl3; Spo8", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase catalytic subunit METTL3; 2.1.1.348; MT-A70; Methyltransferase-like protein 3; N(6)-adenosine-methyltransferase 70 kDa subunit", "protein_names_refseq": "MT-A70; N(6)-adenosine-methyltransferase 70 kDa subunit; N(6)-adenosine-methyltransferase catalytic subunit METTL3; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase subunit METTL3; m6a methyltransferase; methyltransferase like 3; methyltransferase-like protein 3", "tax_id": 10090, "disease": "infertility (Disease Ontology:DOID:5223)", "pathway": " (mmu:56335); (R-MMU-72203)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "11389549;21183079;21750661;24209618;24394384;25428506;25456834;25569111;25683224;28637692;28792938;28809392;28869969;28914256;28965759;29535189;29547716;30084848;32943573;34428180;9409616", "class_list": "", "function": "The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:24394384, PubMed:25456834, PubMed:25569111, PubMed:28792938, PubMed:28809392, PubMed:28869969, PubMed:28965759). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (By similarity). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (PubMed:24394384, PubMed:25456834, PubMed:25569111). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (PubMed:24209618). M6A also regulates circadian regulation of hepatic lipid metabolism (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (PubMed:28809392, PubMed:28914256, PubMed:32943573). Also required for oogenesis (PubMed:32943573). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (By similarity). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (PubMed:28792938). Inhibits the type I interferon response by mediating m6A methylation of IFNB (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (PubMed:28965759). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (By similarity). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (By similarity). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV54;Q9ERS9;Q9WUI4", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "1.13.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.346", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.346", "type": "external" } ], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003729 mRNA binding;GO:0046982 protein heterodimerization activity;GO:0008173 RNA methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0021861 forebrain radial glial cell differentiation;GO:1903679 positive regulation of cap-independent translational initiation;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8C3P7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE11-1", "uniprot_id": [ { "id": "MTMR6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE11", "type": "external" } ], "mass": 70933.0, "length": 617, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6", "gene_name": "Mtmr6", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1", "refseq_ac": [ { "id": "NP_659092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659092", "type": "external" } ], "gene_names_uniprotkb": "Mtmr6", "gene_names_refseq": "4022440C11Rik; Gm38641; Mtmr6", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; 3.1.3.95; Myotubularin-related protein 6; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": " (mmu:219135); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12890864;17947660;18250455;18299400;21952136;22872234;23188820;24591580;25605945;31219806;33649389;34203471;34428180;35820727;37828378", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "L8AZD2", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0032587 ruffle membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006897 endocytosis;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8VE11-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEL0-1", "uniprot_id": [ { "id": "MSPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEL0", "type": "external" } ], "mass": 24074.0, "length": 213, "protein_name": "Motile sperm domain-containing protein 1", "gene_name": "Mospd1", "organism": "Mouse", "refseq_name": "motile sperm domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001277443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277443", "type": "external" } ], "gene_names_uniprotkb": "Mospd1", "gene_names_refseq": "1810018L05Rik; Mospd1", "protein_names_uniprotkb": "Motile sperm domain-containing protein 1", "protein_names_refseq": "motile sperm domain-containing protein 1 isoform 2; motile sperm domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70380)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21792907;26175344;26740625;34203471", "class_list": "", "function": "Mospd1 plays a pivotal role in the developmental regulation at the switch between mesenchymal and epithelial cells., [RefSeq, PubMed]; Plays a role in differentiation and/or proliferation of mesenchymal stem cells (PubMed:21792907, PubMed:26175344). Proposed to be involved in epithelial-to-mesenchymal transition (EMT) (PubMed:21792907). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation (PubMed:26175344)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497P5;Q9D8Y9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VEL0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KQ4-1", "uniprot_id": [ { "id": "NAMPT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KQ4", "type": "external" } ], "mass": 55447.0, "length": 491, "protein_name": "Nicotinamide phosphoribosyltransferase", "gene_name": "Nampt", "organism": "Mouse", "refseq_name": "nicotinamide phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_067499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067499", "type": "external" } ], "gene_names_uniprotkb": "Nampt; Pbef1", "gene_names_refseq": "1110035O14Rik; NAmPRTase; Nampt; Pbef1; Pbef; Visfatin", "protein_names_uniprotkb": "Nicotinamide phosphoribosyltransferase; 2.4.2.12; NAmPRTase; Nampt; PBEF; Pre-B-cell colony-enhancing factor 1 homolog; Visfatin", "protein_names_refseq": "nicotinamide phosphoribosyltransferase; pre-B-cell colony-enhancing factor 1 homolog", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); kidney failure (Disease Ontology:DOID:1074); transient cerebral ischemia (Disease Ontology:DOID:224); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:59027); (R-MMU-196807)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12555668;15381699;16783373;16783377;19286518;19299583;21750661;25428506;25605945;30084848;34428180;36288343;37507081;39927985", "class_list": "", "function": "NAD biosynthesis mediated by Nampt regulates the function of Sir2alpha and plays an important role in controlling various biological events in mammals, [RefSeq, PubMed]; Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis., [RefSeq, PubMed]; The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3B5;Q9JKM0", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.4.2.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.12", "type": "external" } ], "go_molecular_function": "GO:0047280 nicotinamide phosphoribosyltransferase activity;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0005125 cytokine activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0001774 microglial cell activation;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99KQ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60324-1", "uniprot_id": [ { "id": "NANO3_MOUSE", "url": "https://www.uniprot.org/uniprot/P60324", "type": "external" } ], "mass": 19241.0, "length": 178, "protein_name": "Nanos homolog 3", "gene_name": "Nanos3", "organism": "Mouse", "refseq_name": "nanos homolog 3 isoform 1", "refseq_ac": [ { "id": "NP_918948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_918948", "type": "external" } ], "gene_names_uniprotkb": "Nanos3; Nos3", "gene_names_refseq": "Nanos3; nos3", "protein_names_uniprotkb": "Nanos homolog 3; NOS-3", "protein_names_refseq": "nanos homolog 3 isoform 1; nanos homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:244551)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12947200;14962849;17138666;18089289;18436203;19861488;21421998", "class_list": "", "function": "Cloning and functional analyses of nanos2 and nanos3; demonstrated an evolutionarily conserved function of nanos proteins in germ cell development [nanos2] [nanos3], [RefSeq, PubMed]; ENOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater pancreatic microvascular blood flow., [RefSeq, PubMed]; Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDU6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0017148 negative regulation of translation;GO:0007281 germ cell development;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P60324-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70232-1", "uniprot_id": [ { "id": "NCHL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70232", "type": "external" } ], "mass": 135074.0, "length": 1209, "protein_name": "Neural cell adhesion molecule L1-like protein", "gene_name": "Chl1", "organism": "Mouse", "refseq_name": "neural cell adhesion molecule L1-like protein precursor", "refseq_ac": [ { "id": "NP_031723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031723", "type": "external" } ], "gene_names_uniprotkb": "Chl1; Call", "gene_names_refseq": "A530023M13Rik; CALL; Chl1; LICAM2", "protein_names_uniprotkb": "Neural cell adhesion molecule L1-like protein; Cell adhesion molecule with homology to L1CAM; Chl1-like protein; Close homolog of L1", "protein_names_refseq": "cell adhesion molecule with homology to L1CAM; chl1-like protein; close homolog of L1; neural cell adhesion molecule L1-like protein precursor; neural cell adhesion molecule L1-like protein", "tax_id": 10090, "disease": "MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:12661)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10022583;10103075;12391163;12721290;12812975;14659567;14761956;15504324;16623841;21183079;21750661;29325091;30899004;33300544;35820727;8921253", "class_list": "", "function": "Data show that the permanent absence of CHL1 results in misguided axonal projections and aberrant axonal connectivity and alters the exploratory behavior in novel environments, suggesting deficits in information processing in CHL1-deficient mice., [RefSeq, PubMed]; Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 22, "disease_count": 3, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "A2RRK1;Q8BS24;Q8C6W0;Q8C823;Q8VBY7", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045177 apical part of cell;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0008344 adult locomotory behavior;GO:0031175 neuron projection development;GO:0050890 cognition;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "P70232-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5H8-1", "uniprot_id": [ { "id": "NADK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5H8", "type": "external" } ], "mass": 50859.0, "length": 452, "protein_name": "NAD kinase 2, mitochondrial", "gene_name": "Nadk2", "organism": "Mouse", "refseq_name": "NAD kinase 2, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001035485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035485", "type": "external" } ], "gene_names_uniprotkb": "Nadk2; Mnadk; Nadkd1", "gene_names_refseq": "MNADK; Nadk2; Nadkd1", "protein_names_uniprotkb": "NAD kinase 2, mitochondrial; 2.7.1.23; Mitochondrial NAD kinase; NAD kinase domain-containing protein 1, mitochondrial", "protein_names_refseq": "NAD kinase 2, mitochondrial isoform 2; NAD kinase domain-containing protein 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68646); (R-MMU-196807); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21750661;23576753;23616928;23806337;34418053;34428180;35796562;35944895;36631013;37453647", "class_list": "", "function": "Deleting MNADK (NADK2) in mice reduced fat oxidation upon energy demand triggered by endurance exercise or fasting. NADK2 is a major metabolic regulator upon increased energy demand., [RefSeq, PubMed]; MNADK is localized to mitochondria in Hep G2 cells, and a recombinant MNADK showed NAD kinase activity. MNADK is abundant in mitochondrion-rich tissues, such as liver. MNADK expression was suppressed in human liver tumors. Identification of MNADK immediately suggests a model in which NADK and MNADK are responsible for de novo synthesis of NADP(+) in cytosol and mitochondria, respectively. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology., [RefSeq, PubMed]; [Coxsackie virus B3 (CVB3) triggers the activation of NLRP3 in mouse macrophages by activating nicotinamide adenine dinucleotide kinase 2 (NADK2)]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRP5;Q3UEY1;Q9CTE4", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0003951 NAD+ kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0019674 NAD+ metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C5H8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MD9-1", "uniprot_id": [ { "id": "NASP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MD9", "type": "external" } ], "mass": 83954.0, "length": 773, "protein_name": "Nuclear autoantigenic sperm protein", "gene_name": "Nasp", "organism": "Mouse", "refseq_name": "nuclear autoantigenic sperm protein isoform 1", "refseq_ac": [ { "id": "NP_001074944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074944", "type": "external" } ], "gene_names_uniprotkb": "Nasp", "gene_names_refseq": "5033430J04Rik; D4Ertd767e; Epcs32; Nasp-T; Nasp", "protein_names_uniprotkb": "Nuclear autoantigenic sperm protein; NASP", "protein_names_refseq": "nuclear autoantigenic sperm protein isoform 1; somatic histone binding protein NASP", "tax_id": 10090, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (mmu:50927)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10893414;12509435;15533935;16728391;21183079;21750661;23806337;25153642;26495903;28135057;28528544;34428180;34720750;35786450;35820727;36852467;37771504;38605477", "class_list": "", "function": "A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the histone chaperone network (By similarity). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (By similarity). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and linker H1 histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis., [RefSeq, PubMed]; SNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35499;O88993;Q3V150;Q99KE9", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015031 protein transport;GO:0006260 DNA replication;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99MD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5D1E7-1", "uniprot_id": [ { "id": "ZC12A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5D1E7", "type": "external" } ], "mass": 65598.0, "length": 596, "protein_name": "Endoribonuclease ZC3H12A", "gene_name": "Zc3h12a", "organism": "Mouse", "refseq_name": "endoribonuclease ZC3H12A", "refseq_ac": [ { "id": "NP_694799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694799", "type": "external" } ], "gene_names_uniprotkb": "Zc3h12a; Mcpip1; Mcpip", "gene_names_refseq": "MCPIP-1; MCPIP; Mcpip1; Reg1; Zc3h12a", "protein_names_uniprotkb": "Endoribonuclease ZC3H12A; 3.1.-.-; MCP-induced protein 1; MCPIP-1; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; Zinc finger CCCH domain-containing protein 12A", "protein_names_refseq": "MCP-1 treatment-induced protein; MCP-induced protein 1; bifunctional endoribonuclease and deubiquitinase ZC3H12A; endoribonuclease ZC3H12A; monocyte chemotactic protein-induced protein 1; regnase-1; ribonuclease ZC3H12A; zinc finger CCCH domain-containing protein 12A", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hepatitis B (Disease Ontology:DOID:2043)", "pathway": " (mmu:230738)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "16574901;18178554;18682727;19322177;19666473;21115689;21616078;21971051;22037600;22739135;23185455;23706741;25282160;25934862;26000482;26134560;26320658;29244194;34428180;35819231;38830770;39428471", "class_list": "", "function": "Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression. Publication Status: Online-Only, [RefSeq, PubMed]; Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:26000482). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:19322177, PubMed:21115689, PubMed:23185455, PubMed:26000482). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (PubMed:19322177, PubMed:21115689, PubMed:23185455, PubMed:23706741, PubMed:26000482). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (PubMed:29244194, PubMed:35819231). Self regulates by destabilizing its own mRNA (PubMed:22037600). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19322177, PubMed:23185455, PubMed:23706741, PubMed:26000482, PubMed:26134560). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins (PubMed:21115689). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (PubMed:21115689). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation (PubMed:21971051). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (PubMed:25934862). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:18178554, PubMed:19666473, PubMed:22739135). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (PubMed:21616078)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MCP-1 (monocyte chemotactic protein-1)-induced protein is a newly identified protein that can induce adipogenesis without PPARgamma., [RefSeq, PubMed]; MCPIP1 modulates the miRNA-mRNA landscape in keratinocyte carcinomas. Publication Status: Online-Only, [RefSeq, PubMed]; MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation., [RefSeq, PubMed]; Results indicate that Zc3h12a is an essential RNase that prevents immune disorders by directly controlling the stability of a set of inflammatory genes, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8J3;Q3UE76;Q8JZW9;Q922T4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005856 cytoskeleton", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1990869 cellular response to chemokine;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q5D1E7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R109-1", "uniprot_id": [ { "id": "OAZ3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R109", "type": "external" } ], "mass": 28228.0, "length": 243, "protein_name": "Ornithine decarboxylase antizyme 3", "gene_name": "Oaz3", "organism": "Mouse", "refseq_name": "ornithine decarboxylase antizyme 3", "refseq_ac": [ { "id": "NP_058597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058597", "type": "external" } ], "gene_names_uniprotkb": "Oaz3", "gene_names_refseq": "AZ3; Az-3; Oaz-t; Oaz3", "protein_names_uniprotkb": "Ornithine decarboxylase antizyme 3; AZ3; OAZ-t; ODC-Az 3", "protein_names_refseq": "ODC-Az 3; antizyme 3; ornithine decarboxylase antizyme 3; testis specific ornithine decarboxylase antizyme", "tax_id": 10090, "disease": "", "pathway": " (mmu:53814); (R-MMU-350562); (R-MMU-351202)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10781085;10792465;14960325;15642376;16916800;18062773;18508777;18973822;19449338;19893612;21750661;24967154", "class_list": "", "function": "Antizyme expression requires programmed, ribosomal frameshifting, [RefSeq, PubMed]; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:18973822). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (PubMed:24967154)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results define the transcriptional regulatory elements of the OAZt gene promoter; an initiator, a downstream element, and two cyclic adenosine monophosphate-responsive element (CRE)-like sites in the upstream region, [RefSeq, PubMed]; Results indicated that OAZ-t is essential for the formation of a rigid junction between the head and tail during spermatogenesis., [RefSeq, PubMed]; The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) codon that is highly conserved among the antizyme 3 orthologs. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVT4", "ec_number_list": [], "go_molecular_function": "GO:0008073 ornithine decarboxylase inhibitor activity;GO:0071532 ankyrin repeat binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece", "go_biological_process": "GO:1902268 negative regulation of polyamine transmembrane transport;GO:0090316 positive regulation of intracellular protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0051497 negative regulation of stress fiber assembly;GO:0006596 polyamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R109-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q286-1", "uniprot_id": [ { "id": "ICE1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q286", "type": "external" } ], "mass": 242254.0, "length": 2241, "protein_name": "Little elongation complex subunit 1", "gene_name": "Ice1", "organism": "Mouse", "refseq_name": "little elongation complex subunit 1", "refseq_ac": [ { "id": "NP_659086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659086", "type": "external" } ], "gene_names_uniprotkb": "Ice1; Kiaa0947", "gene_names_refseq": "Ice1; mKIAA0947", "protein_names_uniprotkb": "Little elongation complex subunit 1; Interactor of little elongator complex ELL subunit 1", "protein_names_refseq": "interactor of little elongator complex ELL subunit 1; little elongation complex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218333); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;21750661;31219806;34428180;35820727;36210013;40997131", "class_list": "", "function": "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ20", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016604 nuclear body;GO:0015030 Cajal body;GO:0000791 euchromatin", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0031334 positive regulation of protein-containing complex assembly;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9Q286-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB29-1", "uniprot_id": [ { "id": "IAH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB29", "type": "external" } ], "mass": 27974.0, "length": 249, "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "Iah1", "organism": "Mouse", "refseq_name": "isoamyl acetate-hydrolyzing esterase 1 homolog", "refseq_ac": [ { "id": "NP_080623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080623", "type": "external" } ], "gene_names_uniprotkb": "Iah1", "gene_names_refseq": "1500019E20Rik; 4833421E05Rik; Iah1", "protein_names_uniprotkb": "Isoamyl acetate-hydrolyzing esterase 1 homolog; 3.1.-.-", "protein_names_refseq": "isoamyl acetate-hydrolyzing esterase 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67732)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23806337;31219806;32407372;34428180;37453647", "class_list": "", "function": "Iah1 deficiency did not cause liver lipid accumulation Publication Status: Online-Only, [RefSeq, PubMed]; Probable lipase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DB29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15209-1", "uniprot_id": [ { "id": "NTRK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P15209", "type": "external" } ], "mass": 92133.0, "length": 821, "protein_name": "BDNF/NT-3 growth factors receptor", "gene_name": "Ntrk2", "organism": "Mouse", "refseq_name": "BDNF/NT-3 growth factors receptor isoform a precursor", "refseq_ac": [ { "id": "NP_001020245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020245", "type": "external" } ], "gene_names_uniprotkb": "Ntrk2; Trkb", "gene_names_refseq": "GP145-TrkB/GP95-TrkB; Ntrk2; Tkrb; trk-B; trkB", "protein_names_uniprotkb": "BDNF/NT-3 growth factors receptor; 2.7.10.1; GP145-TrkB/GP95-TrkB; Neurotrophic tyrosine kinase receptor type 2; Trk-B; TrkB tyrosine kinase", "protein_names_refseq": "BDNF/NT-3 growth factors receptor isoform a precursor; BDNF/NT-3 growth factors receptor; neurotrophic tyrosine receptor kinase type 2; trkB tyrosine kinase", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); developmental and epileptic encephalopathy 58 (Disease Ontology:DOID:0080285); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); trigeminal neuralgia (Disease Ontology:DOID:12098); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); glaucoma (Disease Ontology:DOID:1686); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); borna disease (Disease Ontology:DOID:5154); intestinal disease (Disease Ontology:DOID:5295); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); vascular dementia (Disease Ontology:DOID:8725); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18212); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9026527); (R-MMU-9028731); (R-MMU-9032759)", "pathway_count": 6, "publication_count": 44, "publication_id_list": "10.1101/2023.09.13.557529;10533983;10571233;12367511;14581459;14603320;15329723;15372074;16113645;16223723;16300803;1645620;16801538;18034455;19675247;21414899;2160854;21666748;21750661;21849472;22396798;23064382;23320097;23785138;23977241;2555172;27019033;27457814;28541476;29311641;30794676;30899004;31494285;31668016;32427585;32550908;32610340;33256199;33300544;33563652;33606976;8402890;9148911;9728914", "class_list": "", "function": "Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 32, "disease_count": 37, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUF9;Q80WU0;Q91XJ9", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0060175 brain-derived neurotrophic factor receptor activity;GO:0002020 protease binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0042490 mechanoreceptor differentiation;GO:0001570 vasculogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 8.8, "record_id": "P15209-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDK1-1", "uniprot_id": [ { "id": "NIT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDK1", "type": "external" } ], "mass": 35705.0, "length": 323, "protein_name": "Deaminated glutathione amidase", "gene_name": "Nit1", "organism": "Mouse", "refseq_name": "deaminated glutathione amidase isoform 2", "refseq_ac": [ { "id": "NP_001229509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229509", "type": "external" } ], "gene_names_uniprotkb": "Nit1", "gene_names_refseq": "ESTM30; Nit1", "protein_names_uniprotkb": "Deaminated glutathione amidase; 3.5.1.128; Nitrilase homolog 1; dGSH amidase", "protein_names_refseq": "dGSH amidase; deaminated glutathione amidase isoform 2; deaminated glutathione amidase; nitrilase homolog 1", "tax_id": 10090, "disease": "brain small vessel disease 4 (Disease Ontology:DOID:0061234)", "pathway": " (mmu:27045)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16864578;19395373;19479888;19595734;19596042;21750661;26967383;28373563;31219806;34428180;9671749", "class_list": "", "function": "Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro (PubMed:28373563). Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data show that cisplatin response was enhanced in human lung cancer cells when Nit1 was knocked down and mice Nit1-/-:KrasG12D/+ tumors showed increased sensitivity to cisplatin in vivo., [RefSeq, PubMed]; Genetic deficiency results in T cell hyperproliferative responses induced by TCR stimulation, spontaneous cell cycle entry and enhanced cell cycle progression, [RefSeq, PubMed]; Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies., [RefSeq, PubMed]; The extent of tumor susceptibility due to Nit1 and Fhit deficiency is additive, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88526;Q9R1N4", "ec_number_list": [ { "id": "3.5.1.128", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.128", "type": "external" } ], "go_molecular_function": "GO:0050406 [acetyl-CoA carboxylase]-phosphatase activity;GO:0110050 deaminated glutathione amidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043605 amide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VDK1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESE1-1", "uniprot_id": [ { "id": "LRBA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESE1", "type": "external" } ], "mass": 317064.0, "length": 2856, "protein_name": "Lipopolysaccharide-responsive and beige-like anchor protein", "gene_name": "Lrba", "organism": "Mouse", "refseq_name": "lipopolysaccharide-responsive and beige-like anchor protein isoform gamma", "refseq_ac": [ { "id": "NP_001071155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071155", "type": "external" } ], "gene_names_uniprotkb": "Lrba; Bgl; Lba", "gene_names_refseq": "D3Ertd775e; Lab300; Lba; Lrba", "protein_names_uniprotkb": "Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein", "protein_names_refseq": "beige-like protein; lipopolysaccharide-responsive and beige-like anchor protein isoform gamma; lipopolysaccharide-responsive and beige-like anchor protein", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); common variable immunodeficiency 8 (Disease Ontology:DOID:0081151)", "pathway": " (mmu:80877)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11254716;15345747;17242355;21183079;21750661;25605945;31219806;33300544;34203471;34428180;35862451;36210013;37208938;38724551", "class_list": "", "function": "A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27., [RefSeq, PubMed]; Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (PubMed:11254716). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; LRBA is essential for urinary concentration and body water homeostasis., [RefSeq, PubMed]; LRBA, a BEACH protein mutated in human immune deficiency, is widely expressed in epithelia, exocrine and endocrine glands, and neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESD3;Q9ESD4", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:1990830 cellular response to leukemia inhibitory factor;GO:0016197 endosomal transport;GO:0034497 protein localization to phagophore assembly site;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9ESE1-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60760-1", "uniprot_id": [ { "id": "GRB10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60760", "type": "external" } ], "mass": 70585.0, "length": 621, "protein_name": "Growth factor receptor-bound protein 10", "gene_name": "Grb10", "organism": "Mouse", "refseq_name": "growth factor receptor-bound protein 10 isoform 2", "refseq_ac": [ { "id": "NP_001171100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171100", "type": "external" } ], "gene_names_uniprotkb": "Grb10; Meg1", "gene_names_refseq": "5730571D09Rik; Grb10; Meg1; mKIAA0207", "protein_names_uniprotkb": "Growth factor receptor-bound protein 10; GRB10 adapter protein; Maternally expressed gene 1 protein", "protein_names_refseq": "GRB10 adapter protein; growth factor receptor-bound protein 10 isoform 2; maternally expressed gene 1 protein", "tax_id": 10090, "disease": "Silver-Russell syndrome (Disease Ontology:DOID:14681)", "pathway": " (mmu:14783); (R-MMU-1433557); (R-MMU-74713); (R-MMU-74749); (R-MMU-74751); (R-MMU-8853659); (R-MMU-9607240)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10454568;10861285;12697834;12771153;12829789;15345747;15664450;15722337;17101788;17242355;17376403;18286479;18650936;19833122;21183079;21750661;28135057;28528544;34428180;7731717;9062339;9448292", "class_list": "", "function": "Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination also has been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Data indicate that bivalent chromatin, in combination with neuronal factors, controls the paternal expression of Grb10 in brain., [RefSeq, PubMed]; Grb10 can influence reproductive strategy through the allocation of maternal resources such that offspring number is offset against size., [RefSeq, PubMed]; Grb10 gene is expressed from the paternal allele in brain, but from the maternal allele in most other tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35352;Q3TQ71;Q7TSA4;Q8BSH4;Q8BSS5;Q91WC5", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0032868 response to insulin;GO:0070371 ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q60760-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AAJ9-1", "uniprot_id": [ { "id": "OBSCN_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AAJ9", "type": "external" } ], "mass": 966591.0, "length": 8886, "protein_name": "Obscurin", "gene_name": "Obscn", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Obscn; Gm878", "gene_names_refseq": "", "protein_names_uniprotkb": "Obscurin; 2.7.11.1; Obscurin-MLCK; Obscurin-RhoGEF; Obscurin-myosin light chain kinase", "protein_names_refseq": "", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:380698); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013406)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "15185077;15289607;21183079;21750661;23392350;28826662;35820727;37507081;39927985", "class_list": "", "function": "Isoform 2 and isoform 3: bind phosphatidylinositol bisphosphates (PIP2s) via their PH domains and negatively regulate the PI3K/AKT/mTOR signaling pathway, thus contributing to the regulation of cardiomyocyte size and adhesion., [UniProtKB, PubMed]; Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (By similarity). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (PubMed:23392350). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AB85;B2FDE7;Q695L2;Q811H7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0016604 nuclear body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0046777 protein autophosphorylation;GO:1902531 regulation of intracellular signal transduction;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A2AAJ9-1", "record_type": "protein", "filter_code": "0000000.1000111.000010.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q956-1", "uniprot_id": [ { "id": "MCMD2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q956", "type": "external" } ], "mass": 76015.0, "length": 681, "protein_name": "Minichromosome maintenance domain-containing protein 2", "gene_name": "Mcmdc2", "organism": "Mouse", "refseq_name": "minichromosome maintenance domain-containing protein 2", "refseq_ac": [ { "id": "NP_808390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808390", "type": "external" } ], "gene_names_uniprotkb": "Mcmdc2; 6030422M02Rik", "gene_names_refseq": "6030422M02Rik; Mcmdc2", "protein_names_uniprotkb": "Minichromosome maintenance domain-containing protein 2; MCM domain-containing protein 2", "protein_names_refseq": "MCM domain-containing protein 2; MCM domain-containing protein C8orf45 homolog; minichromosome maintenance domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240697)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;27760146;27986806", "class_list": "", "function": "In MCMDC2-deficient mice meiosis is arrested in prophase I, and is characterized by persistent meiotic double-stranded DNA breaksfailure of homologous chromosome synapsis and XY body formation, and an absence of crossing over., [RefSeq, PubMed]; Our work suggests that MCMDC2 plays an important role in either the formation, or the stabilization, of DNA strand invasion events that promote homologue alignment and provide the basis for inter-homologue crossover formation during meiotic recombination. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in meiotic recombination and associated DNA double-strand break repair., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YTV7;D6RHP3;Q8CD58", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042140 late meiotic recombination nodule assembly;GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis;GO:1990918 double-strand break repair involved in meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63959-1", "uniprot_id": [ { "id": "KCNC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63959", "type": "external" } ], "mass": 81946.0, "length": 769, "protein_name": "Voltage-gated potassium channel KCNC3", "gene_name": "Kcnc3", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel KCNC3 isoform 1", "refseq_ac": [ { "id": "NP_032448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032448", "type": "external" } ], "gene_names_uniprotkb": "Kcnc3", "gene_names_refseq": "KShIIID; Kcnc3; Kcr2-3; Kv3.3", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC3; KSHIIID; Potassium voltage-gated channel subfamily C member 3; Voltage-gated potassium channel subunit Kv3.3", "protein_names_refseq": "potassium voltage-gated channel subfamily C member 3; voltage-gated potassium channel KCNC3 isoform 1; voltage-gated potassium channel KCNC3; voltage-gated potassium channel subunit Kv3.3", "tax_id": 10090, "disease": "spinocerebellar ataxia 13 (Disease Ontology:DOID:0050963)", "pathway": " (mmu:16504); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11517255;15217387;16452087;16923152;1740329;18448641;18539595;21183079;21750661;24129315;24218544;26997484;34678516;35881790;8301351", "class_list": "", "function": "A missense mutation in Kcnc3 causes hippocampal learning deficits in mice., [RefSeq, PubMed]; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:15217387, PubMed:18539595, PubMed:24218544, PubMed:26997484). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells (PubMed:15217387, PubMed:18448641, PubMed:24218544). Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (PubMed:24218544). Required for normal motor function (PubMed:16923152, PubMed:18448641). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D3YZV2;E9Q5E5;Q62088", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential;GO:0046928 regulation of neurotransmitter secretion;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q63959-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88351-1", "uniprot_id": [ { "id": "IKKB_MOUSE", "url": "https://www.uniprot.org/uniprot/O88351", "type": "external" } ], "mass": 86690.0, "length": 757, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "Ikbkb", "organism": "Mouse", "refseq_name": "inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2", "refseq_ac": [ { "id": "NP_034676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034676", "type": "external" } ], "gene_names_uniprotkb": "Ikbkb; Ikkb", "gene_names_refseq": "IKK-2; IKK-B; IKK-beta; IKK2; IKK[b]; IKKbeta; Ikbkb; NFKBIKB", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit beta; 2.7.11.10; 2.7.11.1; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; IkBKB; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB", "protein_names_refseq": "I-kappa-B kinase 2; I-kappa-B-kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2; inhibitor of nuclear factor kappa-B kinase subunit beta; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); immunodeficiency 15B (Disease Ontology:DOID:0111959); immunodeficiency 15A (Disease Ontology:DOID:0111960); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); prostate adenocarcinoma (Disease Ontology:DOID:2526); dermatitis (Disease Ontology:DOID:2723); liver cancer (Disease Ontology:DOID:3571); pneumonia (Disease Ontology:DOID:552); muscular atrophy (Disease Ontology:DOID:767); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16150); (R-MMU-1169091); (R-MMU-1810476); (R-MMU-202424); (R-MMU-209543); (R-MMU-209560); (R-MMU-2871837); (R-MMU-445989); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5607764); (R-MMU-5684264); (R-MMU-9020702); (R-MMU-933542); (R-MMU-937039); (R-MMU-937041); (R-MMU-975144); (R-MMU-9758274); (R-MMU-9833482); (R-MMU-9860276); (R-MMU-9860927); (R-MMU-9909505)", "pathway_count": 22, "publication_count": 24, "publication_id_list": "10195897;10229185;10523828;10712233;10848580;16207722;16224066;16751795;18202307;19202066;20622870;21183079;21750661;22037600;23090968;25326420;30988283;31219806;34418053;34428180;36210013;38621137;9520401;9819420", "class_list": "", "function": "Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (By similarity). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (By similarity). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (By similarity). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (By similarity). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (By similarity). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (By similarity). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (By similarity). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (By similarity). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (PubMed:30988283). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326420). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-748' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-748' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (By similarity). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1J6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045121 membrane raft;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0061847 response to cholecystokinin;GO:1903140 regulation of establishment of endothelial barrier;GO:1903347 negative regulation of bicellular tight junction assembly;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "O88351-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JX7-1", "uniprot_id": [ { "id": "NXF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JX7", "type": "external" } ], "mass": 70300.0, "length": 618, "protein_name": "Nuclear RNA export factor 1", "gene_name": "Nxf1", "organism": "Mouse", "refseq_name": "nuclear RNA export factor 1 isoform 1", "refseq_ac": [ { "id": "NP_058093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058093", "type": "external" } ], "gene_names_uniprotkb": "Nxf1; Tap", "gene_names_refseq": "Mex67; Mvb1; Nxf1; Tap", "protein_names_uniprotkb": "Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP", "protein_names_refseq": "Mex 67 homolog; mRNA export factor TAP; modifier of vibrator 1; nuclear RNA export factor 1 homolog; nuclear RNA export factor 1 isoform 1; tip associated protein; tip associating protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:53319); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10786854;12093754;16800626;21750661;24129315;28135057;28528544;31918596;32236527;34428180;34887587", "class_list": "", "function": "Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice., [RefSeq, PubMed]; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export., [UniProtKB, UniProtKB]; NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88985;Q3TJA5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0042272 nuclear RNA export factor complex;GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0015031 protein transport;GO:0006405 RNA export from nucleus;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99JX7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VH22-1", "uniprot_id": [ { "id": "IF172_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VH22", "type": "external" } ], "mass": 197548.0, "length": 1749, "protein_name": "Intraflagellar transport protein 172 homolog", "gene_name": "Ift172", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 172 homolog", "refseq_ac": [ { "id": "NP_080574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080574", "type": "external" } ], "gene_names_uniprotkb": "Ift172; Kiaa1179; Wim", "gene_names_refseq": "4930553F24Rik; Ift172; Slb; avc1; wim", "protein_names_uniprotkb": "Intraflagellar transport protein 172 homolog; Protein wimple", "protein_names_refseq": "intraflagellar transport 172 homolog; intraflagellar transport 172 protein; intraflagellar transport protein 172 homolog; protein wimple; selective LIM-binding factor Wimple", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); polycystic kidney disease (Disease Ontology:DOID:0080322); Bardet-Biedl syndrome 20 (Disease Ontology:DOID:0081009); short-rib thoracic dysplasia 10 with or without polydactyly (Disease Ontology:DOID:0110091); retinitis pigmentosa 71 (Disease Ontology:DOID:0110363); VACTERL association (Disease Ontology:DOID:14679); cystic kidney disease (Disease Ontology:DOID:2975); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:67661); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11062270;14603322;16061793;21750661;23055941;23810713;24129315;24339785;31219806;31958312;34203471;34428180;36210013", "class_list": "", "function": "Identification of two mouse mutants, wimple (wim) and flexo (fxo), that lack ventral neural cell types and show other phenotypes characteristic of defects in Sonic hedgehog signalling, [RefSeq, PubMed]; Murine germ cell-specific disruption of Ift172 causes defects in spermiogenesis and male fertility., [RefSeq, PubMed]; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZK1;Q80TI4;Q80W19;Q9DAB0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0061525 hindgut development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6VH22-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58A65-1", "uniprot_id": [ { "id": "JIP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q58A65", "type": "external" } ], "mass": 146219.0, "length": 1321, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 4", "gene_name": "Spag9", "organism": "Mouse", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001020599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020599", "type": "external" } ], "gene_names_uniprotkb": "Spag9; Jip4; Jsap2; Kiaa0516; Mapk8ip4", "gene_names_refseq": "3110018C07Rik; 4733401I23Rik; 4831406C20Rik; JIP-4; JLP; JSAP2a; JSAP2; Jip4; Mapk8ip4; Spag9; syd1", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 4; JIP-4; JLP; JNK-associated leucine-zipper protein; JNK-interacting protein 4; JNK/SAPK-associated protein 2; JSAP2; Mitogen-activated protein kinase 8-interacting protein 4; Sperm-associated antigen 9", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 4 isoform 2; C-jun-amino-terminal kinase-interacting protein 4; JNK-associated leucine-zipper protein; JNK-interacting leucine zipper; JNK-interacting protein 4; JNK/SAPK-associated protein 2; mitogen-activated protein kinase 8-interacting protein 4", "tax_id": 10090, "disease": "endometrial cancer (Disease Ontology:DOID:1380); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:70834); (R-MMU-525793)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12391307;15767678;15987681;17242355;19056739;19131326;21183079;21750661;28135057;28528544;30084848;34428180;37507081", "class_list": "", "function": "Describe a protein, JLP, which acts as a scaffolding protein to bring mitogen-activated protein kinases and their target transcription factors together for the execution of specific signaling pathways, [RefSeq, PubMed]; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (PubMed:19056739)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH77;Q3UHF0;Q58VQ4;Q5NC70;Q5NC78;Q6A057;Q6PAS3;Q8CJC2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0019894 kinesin binding;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0005078 MAP-kinase scaffold activity;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0045665 negative regulation of neuron differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q58A65-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERI5-1", "uniprot_id": [ { "id": "JMJD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERI5", "type": "external" } ], "mass": 46567.0, "length": 403, "protein_name": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "gene_name": "Jmjd6", "organism": "Mouse", "refseq_name": "bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2", "refseq_ac": [ { "id": "NP_203971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203971", "type": "external" } ], "gene_names_uniprotkb": "Jmjd6; Kiaa0585; Ptdsr", "gene_names_refseq": "5730436I23Rik; D11Ertd195e; Jmjd6; PSR; PtdSerR; Ptdsr; mKIAA0585", "protein_names_uniprotkb": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR", "protein_names_refseq": "apoptotic cell clearance receptor PtdSerR; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; histone arginine demethylase JMJD6; jmjC domain-containing protein 6; jumonji domain-containing protein 6; peptide-lysine 5-dioxygenase JMJD6; phosphatidylserine receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:107817); (R-MMU-3214842); (R-MMU-9629569)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10811223;12114511;14645847;14715629;14729065;15345036;15453906;21300889;21750661;25369936;31219806;33443146", "class_list": "", "function": "Data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations, [RefSeq, PubMed]; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization (By similarity). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (PubMed:25369936, PubMed:33443146). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis (PubMed:15345036). Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:21300889). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Protein kinase C beta activation is dependent upon phosphatidylserine receptor action, [RefSeq, PubMed]; This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AA26;A8Y5I2;Q80TX1", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0033746 histone H3R2 demethylase activity;GO:0033749 histone H4R3 demethylase activity;GO:0070815 peptidyl-lysine 5-dioxygenase activity;GO:0003723 RNA binding;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ERI5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI64-1", "uniprot_id": [ { "id": "HUMMR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI64", "type": "external" } ], "mass": 29925.0, "length": 283, "protein_name": "Protein MGARP", "gene_name": "Mgarp", "organism": "Mouse", "refseq_name": "protein MGARP", "refseq_ac": [ { "id": "NP_080634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080634", "type": "external" } ], "gene_names_uniprotkb": "Mgarp; 4930583H14Rik; Cesp1; Hummr; Osap", "gene_names_refseq": "4930583H14Rik; CESP-1; HUMMR; Mgarp; Osap; Qsap", "protein_names_uniprotkb": "Protein MGARP; CESP-1; Corneal endothelium-specific protein 1; Hypoxia up-regulated mitochondrial movement regulator protein; Mitochondria-localized glutamic acid-rich protein; Ovary-specific acidic protein", "protein_names_refseq": "corneal endothelium-specific protein 1; hypoxia up-regulated mitochondrial movement regulator protein; ovary-specific acidic protein; protein MGARP", "tax_id": 10090, "disease": "", "pathway": " (mmu:67749)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10919256;16565373;19325000;19528298;20107910;21447634;21750661;24323429;31202457;36602389", "class_list": "", "function": "DNA methylation-mediated inhibition of MGARP is involved in impaired progeny testosterone synthesis in mice exposed to DBP in utero., [RefSeq, PubMed]; OSAP is prominently expressed in steroidogenic tissues; results suggest that OSAP is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology, [RefSeq, PubMed]; Plays a role in the trafficking of mitochondria along microtubules (PubMed:19325000). Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia (PubMed:19325000). Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion (PubMed:19325000). Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (PubMed:19528298). Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (PubMed:24323429)., [UniProtKB, PubMed, PubMed, PubMed]; The ratio of motile mitochondria was remarkably decreased in the axons of MGARP-overexpressing cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q96EB2;Q9D9Y5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0021987 cerebral cortex development;GO:0071456 cellular response to hypoxia;GO:0006626 protein targeting to mitochondrion;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VI64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42866-1", "uniprot_id": [ { "id": "OPRM_MOUSE", "url": "https://www.uniprot.org/uniprot/P42866", "type": "external" } ], "mass": 44421.0, "length": 398, "protein_name": "Mu-type opioid receptor", "gene_name": "Oprm1", "organism": "Mouse", "refseq_name": "mu-type opioid receptor isoform MOR-1C", "refseq_ac": [ { "id": "NP_001034741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034741", "type": "external" } ], "gene_names_uniprotkb": "Oprm1; Mor; Oprm", "gene_names_refseq": "M-OR-1; MOP-R; MOR-1O; MOR-1; Oprm1; Oprm; mor; muOR", "protein_names_uniprotkb": "Mu-type opioid receptor; M-OR-1; MOR-1", "protein_names_refseq": "MOP receptor; mu opioid receptor MOR-1BI; mu opioid receptor MOR-1P; mu-type opioid receptor isoform MOR-1C; mu-type opioid receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18390); (R-MMU-111885); (R-MMU-202040); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 5, "publication_count": 43, "publication_id_list": "10419560;10682855;10842167;11160404;11717463;12270145;12642578;12939277;14978231;14991152;15827571;15939800;16682964;17284463;17398041;17725581;17825524;18439408;18836069;19029294;21153910;21183079;21422164;21750661;22000021;22437502;22645316;24629717;25801029;26013542;26226422;26245379;27707973;28350844;28818835;30787373;35201898;6933569;7649256;7797593;8090773;9037090;9767386", "class_list": "", "function": "Isoform 9 is involved in morphine-induced scratching and seems to cross-activate GRPR in response to morphine., [UniProtKB, PubMed]; Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10842167, PubMed:16682964, PubMed:21422164, PubMed:22437502, PubMed:26245379, PubMed:7797593, PubMed:9037090). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:16682964, PubMed:7797593, PubMed:9037090). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (PubMed:35201898, PubMed:6933569). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G protein complex and subsequent exchange of GDP for GTP in the G protein alpha subunit leading to dissociation of the G protein complex with the free GTP-bound G protein alpha and the G protein beta-gamma dimer activating downstream cellular effectors (PubMed:10842167, PubMed:21422164, PubMed:22437502). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:26245379, PubMed:9767386). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (PubMed:15827571, PubMed:17725581). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (PubMed:12642578). The activation of the ERK pathway occurs either in a G protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G protein-coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]., [RefSeq]; Upstream open reading frames in mouse MOR mRNA act as negative regulators of translation through a ribosome leaky scanning mechanism., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1XGX3;A1XGX4;A1YAC3;A1YAC4;A5H7G2;Q4U2P4;Q4U2Q6;Q548C6;Q60768;Q6YC50;Q8CAN5;Q8CGW2;Q8CH73;Q8CH74;Q8CH75;Q8VBU3;Q8VBU6;Q8VBX8;Q8VI69;Q8VI70;Q8VI71;Q8VIN3;Q8VIN4;Q8VIN5;Q8VIN6;Q8VIP0;Q8VIP1;Q9JIY1;Q9R0D1;Q9R1L9;Q9R1M0", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0019904 protein domain specific binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0032100 positive regulation of appetite;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P42866-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60929-1", "uniprot_id": [ { "id": "MEF2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60929", "type": "external" } ], "mass": 53579.0, "length": 498, "protein_name": "Myocyte-specific enhancer factor 2A", "gene_name": "Mef2a", "organism": "Mouse", "refseq_name": "myocyte-specific enhancer factor 2A isoform a", "refseq_ac": [ { "id": "NP_001028885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028885", "type": "external" } ], "gene_names_uniprotkb": "Mef2a", "gene_names_refseq": "A430079H05Rik; Mef2a", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2A", "protein_names_refseq": "myocyte-specific enhancer factor 2A isoform a; myocyte-specific enhancer factor 2A", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:17258)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11585834;15834131;17242355;17785444;21183079;21750661;23806337;31219806;34428180;37676887;38483114;40997131;9013788", "class_list": "", "function": "Evolutionary conserved circular MEF2A RNAs regulate myogenic differentiation and skeletal muscle development. Publication Status: Online-Only, [RefSeq, PubMed]; FoxP1 Represses MEF2A in Striated Muscle., [RefSeq, PubMed]; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V155;Q4VA09;Q6P8Q3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0070375 ERK5 cascade;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q60929-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07243-1", "uniprot_id": [ { "id": "MTF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07243", "type": "external" } ], "mass": 72603.0, "length": 675, "protein_name": "Metal regulatory transcription factor 1", "gene_name": "Mtf1", "organism": "Mouse", "refseq_name": "metal regulatory transcription factor 1", "refseq_ac": [ { "id": "NP_032662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032662", "type": "external" } ], "gene_names_uniprotkb": "Mtf1; Mtf-1", "gene_names_refseq": "MTF-1; Mtf1; Thyls", "protein_names_uniprotkb": "Metal regulatory transcription factor 1; MRE-binding transcription factor; Transcription factor MTF-1", "protein_names_refseq": "MRE-binding transcription factor; metal regulatory transcription factor 1; metalloregulatory transcription factor; transcription factor MTF-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17764)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11005378;17242355;21750661;24529376;25428506;26241779;26498180;30084848;30779550;31219806;34428180;8467794", "class_list": "", "function": "Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction., [RefSeq, PubMed]; MTF1 mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:24529376). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (By similarity). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (PubMed:24529376)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJW8", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07243-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61026-1", "uniprot_id": [ { "id": "NCOA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61026", "type": "external" } ], "mass": 158466.0, "length": 1462, "protein_name": "Nuclear receptor coactivator 2", "gene_name": "Ncoa2", "organism": "Mouse", "refseq_name": "nuclear receptor coactivator 2 isoform a", "refseq_ac": [ { "id": "NP_032704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032704", "type": "external" } ], "gene_names_uniprotkb": "Ncoa2; Grip1; Src2; Tif2", "gene_names_refseq": "D1Ertd433e; GRIP-1; Grip1; KAT13C; NCoA-2; Ncoa2; SRC-2; TIF2; bHLHe75", "protein_names_uniprotkb": "Nuclear receptor coactivator 2; GRIP-1; Glucocorticoid receptor-interacting protein 1; NCoA-2; SRC-2; Steroid receptor coactivator 2; Transcriptional intermediary factor 2", "protein_names_refseq": "glucocorticoid receptor interacting protein 1; nuclear receptor coactivator 2 isoform a; steroid receptor coactivator 2; transcriptional intermediary factor 2", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); polycystic ovary syndrome (Disease Ontology:DOID:11612); prostate adenocarcinoma (Disease Ontology:DOID:2526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); malignant pleural mesothelioma (Disease Ontology:DOID:7474); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:17978); (R-MMU-159418); (R-MMU-192105); (R-MMU-193368); (R-MMU-193807); (R-MMU-211976); (R-MMU-3214847); (R-MMU-400206); (R-MMU-5625886); (R-MMU-9018519); (R-MMU-9707564)", "pathway_count": 11, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;10381882;11997499;12477726;12507421;12709428;16148126;17242355;17525332;19039140;19144319;20173027;21183079;21499262;21750661;22517741;22645316;23806337;24129315;24529706;25428506;30084848;31851938;32782141;34428180;35820727;36852467;37094160;37212282;37540802;37962238;40885482;40997131;8643509;9111344;9192892", "class_list": "", "function": "HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1alpha Critical for Mitochondrial Function., [RefSeq, PubMed]; SRC2 controls CD4[+] T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5., [RefSeq, PubMed]; Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation., [RefSeq, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140, PubMed:31851938). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (PubMed:24529706)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 9, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QMH9;O09001;P97759", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043197 dendritic spine;GO:0016604 nuclear body", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:1900076 regulation of cellular response to insulin stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q61026-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1P6-1", "uniprot_id": [ { "id": "NDUA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1P6", "type": "external" } ], "mass": 12576.0, "length": 113, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7", "gene_name": "Ndufa7", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7", "refseq_ac": [ { "id": "NP_075691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075691", "type": "external" } ], "gene_names_uniprotkb": "Ndufa7", "gene_names_refseq": "14.5kDa; 2400007M02Rik; CI-B14.5a; Ndufa7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; CI-B14.5a; Complex I-B14.5a; NADH-ubiquinone oxidoreductase subunit B14.5a", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; NADH-ubiquinone oxidoreductase subunit B14.5a; complex I-B14.5a", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:66416); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10852722;15112104;21750661;22820119;23576753;25428506;31219806;32989924;34428180;36288343;37507081;37828378;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Ndufa7 plays a critical role in cardiac hypertrophy., [RefSeq, PubMed]; The authors characterize complex I, also known as NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, that was purified from bovine heart mitochondria. Biochemical treatment with detergent dissociated the complex into four subfractions. Ndufa7, also known as B14.5a, was found in the I-lambda fraction., [RefSeq, PubMed]; The authors provide an overview of the function and assembly of human complex I, also known as NADH dehydrogenase (ubiquinone) 1 alpha subcomplex. They discuss its role in oxidative phosphorylation and the implications of complex I deficiency in disease. Review article, [RefSeq, PubMed]; This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z1P6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH77-1", "uniprot_id": [ { "id": "NAV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CH77", "type": "external" } ], "mass": 202368.0, "length": 1875, "protein_name": "Neuron navigator 1", "gene_name": "Nav1", "organism": "Mouse", "refseq_name": "neuron navigator 1 isoform 2", "refseq_ac": [ { "id": "NP_775613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775613", "type": "external" } ], "gene_names_uniprotkb": "Nav1; Kiaa1151; Pomfil3", "gene_names_refseq": "9530089B19; 9930003A20Rik; C230080M11Rik; Gm38399; Nav1; Pomfil3; Unc53h1; mKIAA1151; steerin-1", "protein_names_uniprotkb": "Neuron navigator 1; Pore membrane and/or filament-interacting-like protein 3", "protein_names_refseq": "Steerin1; neuron navigator 1 isoform 2; pore membrane and/or filament-interacting-like protein 3", "tax_id": 10090, "disease": "cerebellar hypoplasia (Disease Ontology:DOID:0070338)", "pathway": " (mmu:215690)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;12062803;15345747;15797708;19144319;20173027;21183079;21750661;22517741;22645316;24129315;30059200;31219806;32782141;32848054;34418053;34428180;34678516;36852467;38172636;40021952;40885482", "class_list": "", "function": "May be involved in neuronal migration., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis., [RefSeq, PubMed]; This is the first functional characterization of the mouse homologue, mouse neuron navigator 1 (mNAV1), whose expression is largely restricted to the nervous system during development; mNAV1 associates with microtubules., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5B6;Q68EE8;Q6PB78;Q80TI7;Q8BKG2;Q8BUT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0043194 axon initial segment", "go_biological_process": "GO:0007399 nervous system development;GO:0001764 neuron migration;GO:0001578 microtubule bundle formation;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8CH77-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61983-1", "uniprot_id": [ { "id": "NPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61983", "type": "external" } ], "mass": 51649.0, "length": 465, "protein_name": "Sodium-dependent phosphate transport protein 1", "gene_name": "Slc17a1", "organism": "Mouse", "refseq_name": "sodium-dependent phosphate transport protein 1", "refseq_ac": [ { "id": "NP_001164109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164109", "type": "external" } ], "gene_names_uniprotkb": "Slc17a1; Npt1", "gene_names_refseq": "NAPI-1; Napi1; Npt1; Slc17a1", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 1; Na(+)/PI cotransporter 1; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1", "protein_names_refseq": "Na(+)/PI cotransporter 1; renal Na(+)-dependent phosphate cotransporter 1; renal sodium-phosphate transport protein 1; sodium-dependent phosphate transport protein 1; sodium-dependent phosphate/anion cotransporter; sodium/phosphate type I cotransporter; solute carrier family 17 (sodium/hydrogen exchanger), member 1; solute carrier family 17 vesicular glutamate transporter), member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20504); (R-MMU-427652)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11099500;11704559;21750661;7611445", "class_list": "", "function": "Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A9Z1Z4;Q91YA1", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0046415 urate metabolic process;GO:0006814 sodium ion transport;GO:0035435 phosphate ion transmembrane transport;GO:0015747 urate transport;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61983-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WD5-1", "uniprot_id": [ { "id": "NDUS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WD5", "type": "external" } ], "mass": 52626.0, "length": 463, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "gene_name": "Ndufs2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_694704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694704", "type": "external" } ], "gene_names_uniprotkb": "Ndufs2", "gene_names_refseq": "CI-49kD; Ndufs2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; 7.1.1.2; CI-49kD; Complex I-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform 1; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 49 kDa subunit; complex I-49kD", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 6 (Disease Ontology:DOID:0112066); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); multiple sclerosis (Disease Ontology:DOID:2377); Leigh disease (Disease Ontology:DOID:3652); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (mmu:226646); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "21750661;23576753;25428506;26437605;29887397;30922174;31297047;32279995;33300544;34428180;36288343;37453647;37507081;38575788;39927985", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:26437605, PubMed:29887397, PubMed:31297047, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:26437605, PubMed:29887397, PubMed:31297047). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (PubMed:26437605, PubMed:29887397). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (PubMed:31297047)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Ndufs2-null mice lose the hyperventilatory response to hypoxia, although they respond to hypercapnia. Ndufs2-deficient CB cells have normal functions and ATP content but are insensitive to changes in PO2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNA8;Q3U5Y9;Q3UJX7;Q99L23", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0031625 ubiquitin protein ligase binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042063 gliogenesis;GO:0022008 neurogenesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91WD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53395-1", "uniprot_id": [ { "id": "ODB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P53395", "type": "external" } ], "mass": 53247.0, "length": 482, "protein_name": "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "gene_name": "Dbt", "organism": "Mouse", "refseq_name": "lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_034152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034152", "type": "external" } ], "gene_names_uniprotkb": "Dbt", "gene_names_refseq": "BCKAD E2; BCKAD-E2; D3Wsu60e; Dbt", "protein_names_uniprotkb": "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; 2.3.1.168; BCKAD-E2; BCKADE2; Branched-chain alpha-keto acid dehydrogenase complex component E2; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Dihydrolipoamide branched chain transacylase; Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase", "protein_names_refseq": "branched-chain alpha-keto acid dehydrogenase complex component E2; branched-chain alpha-ketoacid dehydrogenase, E2 subunit; dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; dihydrolipoyl transacylase; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 1; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; part of the BCKAD complex", "tax_id": 10090, "disease": "maple syrup urine disease type II (Disease Ontology:DOID:0061207); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (mmu:13171); (R-MMU-70895); (R-MMU-9013407); (R-MMU-9837999); (R-MMU-9857492); (R-MMU-9859138)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "21750661;23576753;23806337;34428180;36288343;37453647;37507081;39927985;8605244", "class_list": "", "function": "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMF5", "ec_number_list": [ { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.200", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.200", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0043754 dihydrolipoamide branched chain acyltransferase activity;GO:0031625 ubiquitin protein ligase binding;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53395-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R480-1", "uniprot_id": [ { "id": "NUP85_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R480", "type": "external" } ], "mass": 74776.0, "length": 656, "protein_name": "Nuclear pore complex protein Nup85", "gene_name": "Nup85", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup85", "refseq_ac": [ { "id": "NP_001002929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002929", "type": "external" } ], "gene_names_uniprotkb": "Nup85; Pcnt1", "gene_names_refseq": "Nup85; Pcnt1; frount", "protein_names_uniprotkb": "Nuclear pore complex protein Nup85; 85 kDa nucleoporin; FROUNT; Nucleoporin Nup85; Pericentrin-1", "protein_names_refseq": "85 kDa nucleoporin; nuclear pore complex protein Nup85; nucleoporin Nup85; pericentrin-1", "tax_id": 10090, "disease": "nephrotic syndrome type 17 (Disease Ontology:DOID:0080392)", "pathway": " (mmu:445007); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 12, "publication_id_list": "12718872;15995708;21750661;23806337;30084848;31219806;32001710;33300544;34428180;35820727;36912786;38617542", "class_list": "", "function": "Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85., [RefSeq, PubMed]; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis., [UniProtKB, UniProtKB]; FROUNT links activated CCR2 to the PI(3)K-Rac-lamellipodium protrusion cascade in monocyte chemotaxis, [RefSeq, PubMed]; Functions as a component of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB, UniProtKB]; NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease. Publication Status: Online-Only, [RefSeq, PubMed]; The chemokine signal regulator FROUNT is identified as a target to control tumor-associated macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9W9;A2A9X0;Q9CYI9", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0072006 nephron development;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006935 chemotaxis;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R480-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4G0-1", "uniprot_id": [ { "id": "NTNG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4G0", "type": "external" } ], "mass": 60566.0, "length": 539, "protein_name": "Netrin-G1", "gene_name": "Ntng1", "organism": "Mouse", "refseq_name": "netrin-G1 isoform b", "refseq_ac": [ { "id": "NP_001156820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156820", "type": "external" } ], "gene_names_uniprotkb": "Ntng1; Kiaa0976; Lmnt1", "gene_names_refseq": "A930010C08Rik; Lmnt1; Ntng1", "protein_names_uniprotkb": "Netrin-G1; Laminet-1", "protein_names_refseq": "laminet-1; netrin-G1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:80883)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10964959;11804778;11906208;21750661;30899004;31692205", "class_list": "", "function": "Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q68FE5;Q69ZU3;Q8R4F3;Q8R4F4;Q8R4F5;Q8R4F6;Q8R4F7;Q8R4F8;Q8R4F9;Q9ESR3;Q9ESR4;Q9ESR5;Q9ESR6;Q9ESR7;Q9ESR8", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0098685 Schaffer collateral - CA1 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0009887 animal organ morphogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0010975 regulation of neuron projection development;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8R4G0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBE6-1", "uniprot_id": [ { "id": "P4K2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2TBE6", "type": "external" } ], "mass": 54258.0, "length": 479, "protein_name": "Phosphatidylinositol 4-kinase type 2-alpha", "gene_name": "Pi4k2a", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-kinase type 2-alpha", "refseq_ac": [ { "id": "NP_663476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663476", "type": "external" } ], "gene_names_uniprotkb": "Pi4k2a", "gene_names_refseq": "Pi4k2a; Pi4k2", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-alpha; 2.7.1.67; Phosphatidylinositol 4-kinase type II-alpha", "protein_names_refseq": "phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:84095); (R-MMU-1660499); (R-MMU-1660514); (R-MMU-1660516)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "15944223;16772528;17242355;19144319;19581584;21183079;21750661;21998198;22105363;23146885;26495903;26740625;28011936;28935714;33618608", "class_list": "", "function": "Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)., [UniProtKB, PubMed]; Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation., [RefSeq, PubMed]; PI4KIIalpha is present on adaptor protein (AP) -3 organelles where it regulates AP-3 function, [RefSeq, PubMed]; The unique N terminus of PI4K type IIalpha is required for the targeting of the enzyme to cellugyrin-positive vesicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0035651 AP-3 adaptor complex binding;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035838 growing cell tip;GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:0002561 basophil degranulation;GO:0007032 endosome organization;GO:0006661 phosphatidylinositol biosynthetic process;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q2TBE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIF2-1", "uniprot_id": [ { "id": "RFOX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIF2", "type": "external" } ], "mass": 40610.0, "length": 374, "protein_name": "RNA binding protein fox-1 homolog 3", "gene_name": "Rbfox3", "organism": "Mouse", "refseq_name": "RNA binding protein fox-1 homolog 3 isoform 3", "refseq_ac": [ { "id": "NP_001020102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020102", "type": "external" } ], "gene_names_uniprotkb": "Rbfox3; D11Bwg0517e; Hrnbp3", "gene_names_refseq": "Fox-3; Hrnbp3; NeuN; Neuna60; Rbfox3", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 3; Fox-1 homolog C; Fox-3; Hexaribonucleotide-binding protein 3; NeuN antigen; Neuronal nuclei antigen", "protein_names_refseq": "RNA binding protein fox-1 homolog 3 isoform 3; RNA binding protein fox-1 homolog 3; fox-1 homolog C; hexaribonucleotide binding protein 3; neuN antigen; neuronal nuclear antigen A60; neuronal nuclei antigen", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:52897)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1483388;15605376;19713214;20042473;21747913;21750661;24129315;26619789;34678516", "class_list": "", "function": "Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A4W7;A2A4W8;B7ZC12;B7ZC13;D1GI07;Q3TUE0;Q7TQI4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BIF2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97438-1", "uniprot_id": [ { "id": "KCNK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97438", "type": "external" } ], "mass": 46844.0, "length": 426, "protein_name": "Potassium channel subfamily K member 2", "gene_name": "Kcnk2", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 2 isoform 1", "refseq_ac": [ { "id": "NP_001153322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153322", "type": "external" } ], "gene_names_uniprotkb": "Kcnk2", "gene_names_refseq": "A430027H14Rik; K2P2.1; Kcnk2; TREK-1", "protein_names_uniprotkb": "Potassium channel subfamily K member 2; K2P2.1; Outward rectifying potassium channel protein TREK-1; TREK-1 K(+) channel subunit; Two pore potassium channel TPKC1", "protein_names_refseq": "TREK-1 K(+) channel subunit; outward rectifying potassium channel protein TREK-1; potassium channel subfamily K member 2 isoform 1; two pore potassium channel TPKC1", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:16526); (R-MMU-1299503); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10321245;16636285;17110924;19667202;21183079;21750661;22354168;22726831;23021213;24496152;26642364;27035963;27035965;28693035;30573346;33127683;34458705;38252657;38344766;38601986;9003761", "class_list": "", "function": "K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner (By similarity) (PubMed:10321245, PubMed:16636285, PubMed:17110924, PubMed:19667202, PubMed:28693035, PubMed:9003761). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:24496152, PubMed:27035963, PubMed:27035965). In trigeminal ganglia sensory neurons, the heterodimer of KCNK2/TREK-1 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (PubMed:30573346, PubMed:34458705). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (By similarity). In hippocampal astrocytes, the heterodimer of KCNK2/TREK-1 and KCNK1/TWIK-1 allows passive K(+) conductance under basal conditions, but changes ion selectivity and becomes permeable to L-glutamate and Cl(-) ions upon binding to G protein subunit GNG4 in stimulated astrocytes. Mediates rapid L-glutamate release in response to activation of G protein-coupled receptors such as F2R and CNR1 (PubMed:23021213, PubMed:24496152). In hippocampal pyramidal neurons, the homodimer of KCNK2/TREK-1 contributes to gamma-aminobutyric acid (GABA) B-induced slow inhibitory postsynaptic potential. Associates with AKAP5 and Gs-protein-coupled receptor B2AR at postsynaptic dense bodies and converts to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (PubMed:17110924, PubMed:22726831). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age., [RefSeq, PubMed]; Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice., [RefSeq, PubMed]; Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4VQI2", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0030322 stabilization of membrane potential;GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0003231 cardiac ventricle development;GO:1900039 positive regulation of cellular response to hypoxia;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97438-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUG9-1", "uniprot_id": [ { "id": "GRP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUG9", "type": "external" } ], "mass": 69446.0, "length": 608, "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "Rasgrp2", "organism": "Mouse", "refseq_name": "RAS guanyl-releasing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_035372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035372", "type": "external" } ], "gene_names_uniprotkb": "Rasgrp2", "gene_names_refseq": "CDC25L; CalDAG-GEFI; Caldaggef1; Rasgrp2", "protein_names_uniprotkb": "RAS guanyl-releasing protein 2; CalDAG-GEFI; Calcium and DAG-regulated guanine nucleotide exchange factor I; F25B3.3 kinase-like protein", "protein_names_refseq": "F25B3.3 kinase like protein; RAP 1A protein-specific guanine nucleotide exchange factor 1; RAS guanyl-releasing protein 2 isoform 1; calcium and DAG-regulated guanine nucleotide exchange factor I", "tax_id": 10090, "disease": "leukocyte adhesion deficiency 3 (Disease Ontology:DOID:0110912); platelet-type bleeding disorder 18 (Disease Ontology:DOID:0111051)", "pathway": " (mmu:19395); (R-MMU-354192); (R-MMU-392517)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10777492;10835426;10913189;11278453;11432821;12239348;15334074;16357324;17242355;17492052;20173027;21183079;21750661;21952136;25605945;28690878;30084848;30779550;34371144;34428180;36351540;9341881;9789079", "class_list": "", "function": "CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors., [RefSeq, PubMed]; CalDAG-GEFI plays a role in inside-out signaling to alphaIIbbeta3, [RefSeq, PubMed]; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09004;Q80WC0;Q8BSC8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006955 immune response;GO:0043547 positive regulation of GTPase activity;GO:0071277 cellular response to calcium ion;GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9QUG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03267-1", "uniprot_id": [ { "id": "IKZF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03267", "type": "external" } ], "mass": 57336.0, "length": 517, "protein_name": "DNA-binding protein Ikaros", "gene_name": "Ikzf1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ikzf1; Ikaros; Lyf1; Zfpn1a1; Znfn1a1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); common variable immunodeficiency 13 (Disease Ontology:DOID:0081155); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:22778); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10544193;10970879;11003653;12464629;1439790;15024069;15767674;16369973;18223295;18940586;19282287;21183079;21750661;25605945;31219806;34428180;39627609;7935426;9155026", "class_list": "", "function": "Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells (By similarity). Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 52, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64044;Q64045;Q64051", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q03267-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C735-1", "uniprot_id": [ { "id": "LIN9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C735", "type": "external" } ], "mass": 61759.0, "length": 542, "protein_name": "Protein lin-9 homolog", "gene_name": "Lin9", "organism": "Mouse", "refseq_name": "protein lin-9 homolog", "refseq_ac": [ { "id": "NP_001096652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096652", "type": "external" } ], "gene_names_uniprotkb": "Lin9; Bara; Tgs1", "gene_names_refseq": "2700022J23Rik; Bara; Lin-9; Lin9; TGS1; TGS; mLin-9", "protein_names_uniprotkb": "Protein lin-9 homolog; TUDOR gene similar 1 protein; Type I interferon receptor beta chain-associated protein; mLin-9", "protein_names_refseq": "TUDOR gene similar 1 protein; lin-9 homolog; protein lin-9 homolog; type I interferon receptor beta chain-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72568); (R-MMU-1538133)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16730350;17098733;17563750;19252525;21183079;21750661;34388164", "class_list": "", "function": "Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity)., [UniProtKB]; Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin., [RefSeq, PubMed]; Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1, [RefSeq, PubMed]; Mutation of BARA/LIN-9 restores the expression of E2F target genes in CDK4 null Mouse Embryo Fibroblasts, indicating that the wild-type protein plays a role in the expression of genes required for the G1/S transition., [RefSeq, PubMed]; Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility. Publication Status: Online-Only, [RefSeq, PubMed]; The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5TKA0;Q8C9D8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005634 nucleus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C735-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD75-1", "uniprot_id": [ { "id": "HIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD75", "type": "external" } ], "mass": 115202.0, "length": 1029, "protein_name": "Huntingtin-interacting protein 1", "gene_name": "Hip1", "organism": "Mouse", "refseq_name": "huntingtin-interacting protein 1 isoform 1", "refseq_ac": [ { "id": "NP_666113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666113", "type": "external" } ], "gene_names_uniprotkb": "Hip1; Kiaa4113", "gene_names_refseq": "2610109B09Rik; A930014B11Rik; E130315I21Rik; Hip1; mKIAA4113", "protein_names_uniprotkb": "Huntingtin-interacting protein 1; HIP-1; HIP-I; Huntingtin-interacting protein I", "protein_names_refseq": "HIP-I; huntingtin-interacting protein 1 isoform 1; huntingtin-interacting protein I", "tax_id": 10090, "disease": "", "pathway": " (mmu:215114); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11577110;11604514;12839988;14998932;16967501;17329427;17452370;17928447;21750661;34428180;35820727;9140394", "class_list": "", "function": "Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11577110). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (PubMed:12839988, PubMed:17329427). Regulates presynaptic nerve terminal activity (PubMed:17928447). Enhances androgen receptor (AR)-mediated transcription (By similarity). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (By similarity). Binds 3-phosphoinositides (via ENTH domain) (By similarity). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (By similarity). May play a functional role in the cell filament networks (By similarity). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11604514, PubMed:14998932, PubMed:16967501, PubMed:17928447)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLS2;Q571K7", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding;GO:0035612 AP-2 adaptor complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0006351 DNA-templated transcription;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VD75-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AAE1-1", "uniprot_id": [ { "id": "BLTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AAE1", "type": "external" } ], "mass": 555365.0, "length": 5005, "protein_name": "Bridge-like lipid transfer protein family member 1", "gene_name": "Bltp1", "organism": "Mouse", "refseq_name": "bridge-like lipid transfer protein family member 1", "refseq_ac": [ { "id": "NP_766267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766267", "type": "external" } ], "gene_names_uniprotkb": "Bltp1; 4932438A13Rik; Fsa; Kiaa1109; Kiaa1371", "gene_names_refseq": "4732443H21; 4932438A13Rik; B830039D19Rik; Bltp1; D630029K19Rik; FSA; Kiaa1109; Tweek", "protein_names_uniprotkb": "Bridge-like lipid transfer protein family member 1; Fragile site-associated protein homolog", "protein_names_refseq": "bridge-like lipid transfer protein family member 1; fragile site-associated protein homolog", "tax_id": 10090, "disease": "Alkuraya-Kucinskas syndrome (Disease Ontology:DOID:0111555)", "pathway": " (mmu:229227)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16545529;19144319;21183079;21750661;25428506;25605945;26740625;29187734;30084848;31219806;31599954;34428180;35820727", "class_list": "", "function": "Bridge-like lipid transfer protein that functions as molecular bridges between endoplasmic reticulum and the membranes targeted for lipid delivery (By similarity). Forms a tunnel with multiple beta-grooves that allows the transport of phospholipids (By similarity). Provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (By similarity). Plays a role in endosomal trafficking and endosome recycling (By similarity). Also involved in the actin cytoskeleton and cilia structural dynamics (By similarity). Acts as a regulator of phagocytosis (By similarity). Required for the formation of endoplasmic reticulum-plasma membrane junctions which are critical for lipid exchange (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AAD2;A2AAD4;E9Q376;Q05BP8;Q3UG08;Q3UYB7;Q571C4;Q69ZR8;Q6AXD9;Q8BWF1;Q8BY77;Q8CEA4;Q8R0A8", "ec_number_list": [], "go_molecular_function": "GO:1904121 phosphatidylethanolamine transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0007283 spermatogenesis;GO:0009409 response to cold;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "A2AAE1-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCB2-1", "uniprot_id": [ { "id": "MED25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCB2", "type": "external" } ], "mass": 78113.0, "length": 745, "protein_name": "Mediator of RNA polymerase II transcription subunit 25", "gene_name": "Med25", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 25 isoform 2", "refseq_ac": [ { "id": "NP_001318135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001318135", "type": "external" } ], "gene_names_uniprotkb": "Med25", "gene_names_refseq": "2610034E13Rik; 2610529E18Rik; ESTM2; Med25", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 25; Mediator complex subunit 25; mMED25", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 25 isoform 2; mediator of RNA polymerase II transcription subunit 25; mediator of RNA polymerase II transcription, subunit 9 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75613)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17641689;19290556;21750661;22952853;24129315;30084848;31219806;34428180;37047128;40997131", "class_list": "", "function": "Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, UniProtKB, UniProtKB]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that Med25 is coordinately expressed with Pmp22 gene dosage and expression in transgenic mice and rats, and suggest a potential role of this protein in the molecular etiology of Charcot-Marie-Tooth disease. Erratum:[Neurogenetics. 2009 Oct;10(4):375-376. doi: 10.1007/s10048-009-0213-1. Sereda, Michael [corrected to Sereda, Michael Werner]; Stassart, Ruth Martha [added]. PMID: 25488817], [RefSeq, PubMed]; Med25 Limits Master Regulators That Govern Adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The identification of MED25 as one of the HNF4alpha binding partners in pancreatic ss-cells leading to insulin secretion which is impaired in MODY patients, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDX6;Q3UFQ1;Q6IR27", "ec_number_list": [], "go_molecular_function": "GO:0042974 nuclear retinoic acid receptor binding;GO:0001223 transcription coactivator binding;GO:0046965 nuclear retinoid X receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:2001178 positive regulation of mediator complex assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VCB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CB67-1", "uniprot_id": [ { "id": "LRP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CB67", "type": "external" } ], "mass": 51814.0, "length": 483, "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "Lrp11", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 11 isoform 1 precursor", "refseq_ac": [ { "id": "NP_766372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766372", "type": "external" } ], "gene_names_uniprotkb": "Lrp11", "gene_names_refseq": "1700034J19Rik; 6330533B21; 9830160H19Rik; Lrp11", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 11; LRP-11", "protein_names_refseq": "LRP-11; low-density lipoprotein receptor-related protein 11 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:237253)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7Y7", "ec_number_list": [], "go_molecular_function": "GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0009409 response to cold;GO:0042594 response to starvation;GO:0009612 response to mechanical stimulus;GO:0009414 response to water deprivation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CB67-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A7S8-1", "uniprot_id": [ { "id": "NHSL3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A7S8", "type": "external" } ], "mass": 104842.0, "length": 1013, "protein_name": "NHS-like protein 3", "gene_name": "Nhsl3", "organism": "Mouse", "refseq_name": "NHS-like protein 3 isoform a", "refseq_ac": [ { "id": "NP_001028361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028361", "type": "external" } ], "gene_names_uniprotkb": "Nhsl3; Kiaa1522", "gene_names_refseq": "C77080; Nhsl3; mKIAA1522", "protein_names_uniprotkb": "NHS-like protein 3", "protein_names_refseq": "NHS-like protein 3 isoform a; NHS-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:97130)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16452087;17242355;17947660;19144319;21183079;21750661;24129315;25428506;30084848;31616917;35820727", "class_list": "", "function": "Able to directly activate the TNF-NFkappaB signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A7S9;Q3U356;Q3U437;Q3V3N0;Q6ZPN9;Q8K0K8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2A7S8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PG16-1", "uniprot_id": [ { "id": "HJURP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PG16", "type": "external" } ], "mass": 74199.0, "length": 667, "protein_name": "Holliday junction recognition protein", "gene_name": "Hjurp", "organism": "Mouse", "refseq_name": "Holliday junction recognition protein", "refseq_ac": [ { "id": "NP_766093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766093", "type": "external" } ], "gene_names_uniprotkb": "Hjurp; Fleg1", "gene_names_refseq": "A730008H23Rik; Fleg1", "protein_names_uniprotkb": "Holliday junction recognition protein; Fetal liver expressing gene 1 protein homolog; mFleg1", "protein_names_refseq": "Holliday junction recognition protein; fetal liver expressing gene 1 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:212427); (mmu:381280); (R-MMU-606279); (R-MMU-69273)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6BCZ4;Q8C9A7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0043254 regulation of protein-containing complex assembly;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PG16-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41230-1", "uniprot_id": [ { "id": "KDM5C_MOUSE", "url": "https://www.uniprot.org/uniprot/P41230", "type": "external" } ], "mass": 175313.0, "length": 1554, "protein_name": "Lysine-specific demethylase 5C", "gene_name": "Kdm5c", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 5C isoform 1", "refseq_ac": [ { "id": "NP_038696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038696", "type": "external" } ], "gene_names_uniprotkb": "Kdm5c; Jarid1c; Kiaa0234; Smcx; Xe169", "gene_names_refseq": "D930009K15Rik; Jarid1c; Kdm5c; Smcx; mKIAA0234", "protein_names_uniprotkb": "Lysine-specific demethylase 5C; 1.14.11.67; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169; [histone H3]-trimethyl-L-lysine(4) demethylase 5C", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(4) demethylase 5C; histone demethylase JARID1C; jumonji, AT rich interactive domain 1C (Rbp2 like); jumonji/ARID domain-containing protein 1C; lysine (K)-specific demethylase 5C; lysine-specific demethylase 5C isoform 1; lysine-specific demethylase 5C; selected mouse cDNA on the X", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); descending colon cancer (Disease Ontology:DOID:12190); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:20591); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10441747;21183079;21750661;21960634;31219806;31599954;34428180;38912581;39052479;7544442;7951230;7951318;9723615", "class_list": "", "function": "Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2., [UniProtKB, UniProtKB, PubMed]; Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54995;Q3TYU8;Q3U1X6;Q3U282;Q6ZQF8;Q80XQ9;Q9CVI4;Q9D0C3;Q9QVR8;Q9R039", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P41230-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN9-1", "uniprot_id": [ { "id": "JIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESN9", "type": "external" } ], "mass": 147561.0, "length": 1337, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 3", "gene_name": "Mapk8ip3", "organism": "Mouse", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 3 isoform b", "refseq_ac": [ { "id": "NP_001156919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156919", "type": "external" } ], "gene_names_uniprotkb": "Mapk8ip3; Jip3; Jsap1; Syd2", "gene_names_refseq": "D17Wsu15e; JIP-3; JSAP1a; JSAP1b; JSAP1c; JSAP1d; JSAP1; Jip3; Mapk8ip3; Syd2; mKIAA1066", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JSAP1; Mitogen-activated protein kinase 8-interacting protein 3; Sunday driver 2", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 3 isoform b; C-jun-amino-terminal kinase-interacting protein 3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1c; JNK/SAPK-associated protein 1; JUN/SAPK-associated protein 1; c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; sunday driver 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:30957)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10523642;10629060;11024282;11106729;11238452;16452087;21183079;21750661;21775604;23576431;25428506;25605945;25944905;28259553;28784610;29454969;29604277;30899004;31219806;32062074;34428180", "class_list": "", "function": "C-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 is a critical regulator for arthritis progression by meditating inflammation in mice model., [RefSeq, PubMed]; JIP3 absence is associated with decreased lipogenesis, oxidative stress and inflammation, supplying a new target for nonalcoholic fatty liver disease treatment., [RefSeq, PubMed]; JIP3-KO mice after aortic banding exhibited attenuated cardiac function, reduced fibrosis levels and decreased hypertrophic marker proteins. Loss of JIP3 also ameliorated oxidative stress, inflammatory response, apoptosis and endoplasmic reticulum (ER) stress in hearts., [RefSeq, PubMed]; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; These results establish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein processing and support a model wherein Abeta production is amplified by plaque-induced axonal lysosome transport defects., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5D062;Q99KU7;Q9EQD8;Q9ESN7;Q9ESN8;Q9ESP0;Q9JLH2;Q9JLH3;Q9R0U7", "ec_number_list": [], "go_molecular_function": "GO:0031434 mitogen-activated protein kinase kinase binding;GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity;GO:0030159 signaling receptor complex adaptor activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0001701 in utero embryonic development;GO:0030900 forebrain development;GO:0043066 negative regulation of apoptotic process;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9ESN9-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI11-1", "uniprot_id": [ { "id": "GNL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI11", "type": "external" } ], "mass": 60786.0, "length": 538, "protein_name": "Guanine nucleotide-binding protein-like 3", "gene_name": "Gnl3", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein-like 3", "refseq_ac": [ { "id": "NP_705775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705775", "type": "external" } ], "gene_names_uniprotkb": "Gnl3; Ns", "gene_names_refseq": "Gnl3; Ns", "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 3; Nucleolar GTP-binding protein 3; Nucleostemin", "protein_names_refseq": "guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; nucleolar GTP-binding protein 3; nucleostemin", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:30877); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12464630;15857956;17000755;17000763;19144319;21132010;21183079;21750661;24140061;25153642;25522312;28135057;28528544;30692636;31219806", "class_list": "", "function": "Analysis of nucleolar localization of stem cell protein nucleostemin, [RefSeq, PubMed]; Has roles in establishing early embryogenesis and delaying cellular senescence of embryonic fibroblasts., [RefSeq, PubMed]; May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation., [UniProtKB, PubMed]; Nucleostemin expression participates in the preservation of the viability and integrity of embryonic stem cells., [RefSeq, PubMed]; Nucleostemin has a unique ability, derived from an ancestral function, to control the proliferation rate of stem/progenitor cells in vivo independently of p53., [RefSeq, PubMed]; Nucleostemin protects hematopoietic stem cells (HSCs) from DNA damage accumulation and is required for the maintenance of HSCs., [RefSeq, PubMed]; Nucleostemin role in the mammary tumor progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811R9;Q811S8;Q8BK21", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0030496 midbody", "go_biological_process": "GO:1904816 positive regulation of protein localization to chromosome, telomeric region;GO:0042127 regulation of cell population proliferation;GO:0019827 stem cell population maintenance;GO:0033235 positive regulation of protein sumoylation;GO:0017145 stem cell division", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8CI11-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q0C6-1", "uniprot_id": [ { "id": "K1210_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q0C6", "type": "external" } ], "mass": 181033.0, "length": 1637, "protein_name": "Acrosomal protein KIAA1210", "gene_name": "Kiaa1210", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kiaa1210; Gm14569", "gene_names_refseq": "", "protein_names_uniprotkb": "Acrosomal protein KIAA1210", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "28203736;34203471", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q0C6-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19001-1", "uniprot_id": [ { "id": "K1C19_MOUSE", "url": "https://www.uniprot.org/uniprot/P19001", "type": "external" } ], "mass": 44542.0, "length": 403, "protein_name": "Keratin, type I cytoskeletal 19", "gene_name": "Krt19", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 19 isoform 1", "refseq_ac": [ { "id": "NP_032497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032497", "type": "external" } ], "gene_names_uniprotkb": "Krt19; Krt1-19", "gene_names_refseq": "CK-19; EndoC; K19; Krt-1.19; Krt1-19; Krt19", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 19; CK-19; Cytokeratin-19; K19; Keratin-19", "protein_names_refseq": "cytokeratin 19; keratin complex 1, acidic, gene 19; keratin, type I cytoskeletal 19 isoform 1; keratin, type I cytoskeletal 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:16669); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "1701153;21049038;21183079;24129315;2479589;2483396;28011936;32782141;34428180;34887587;36583994;41018975", "class_list": "", "function": "Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity)., [UniProtKB]; The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008307 structural constituent of muscle;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0042383 sarcolemma", "go_biological_process": "GO:0060706 cell differentiation involved in embryonic placenta development;GO:0007219 Notch signaling pathway;GO:0030855 epithelial cell differentiation;GO:0043627 response to estrogen;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P19001-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63141-1", "uniprot_id": [ { "id": "KCNA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P63141", "type": "external" } ], "mass": 56701.0, "length": 499, "protein_name": "Potassium voltage-gated channel subfamily A member 2", "gene_name": "Kcna2", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 2", "refseq_ac": [ { "id": "NP_032443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032443", "type": "external" } ], "gene_names_uniprotkb": "Kcna2", "gene_names_refseq": "Akr6a4; Gm10672; Kca1-2; Kcna2; Kv1.2; Mk-2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 2; MK2; Voltage-gated potassium channel subunit Kv1.2", "protein_names_refseq": "MK2; potassium voltage-gated channel subfamily A member 2; voltage-gated potassium channel subunit Kv1.2", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); developmental and epileptic encephalopathy 32 (Disease Ontology:DOID:0080416); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:16490); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;12527813;1691985;17634333;17917103;17925011;18034455;18056633;18509034;18760366;20696761;21183079;21233214;22649228;2305265;23332758;23864368;23981714;25378149;26269648;30059200;30224722;33300544;34428180;37607607;40021952;40885482;8046438;8361541;9635436;9852577", "class_list": "", "function": "Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:12527813, PubMed:21233214). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20696761). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:23864368). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:23864368). Contributes to the regulation of action potentials in neurons (PubMed:12527813, PubMed:17925011). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (PubMed:17634333, PubMed:17925011). Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). KCNA2-containing channels play a role in GABAergic transmission from basket cells to Purkinje cells in the cerebellum, and thereby play an import role in motor coordination (PubMed:20696761). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (PubMed:23981714). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (PubMed:21233214). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (PubMed:17925011)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RS05;P15386;Q02010;Q8C8W4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0019894 kinesin binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034705 potassium channel complex;GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0021633 optic nerve structural organization;GO:0019228 neuronal action potential;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0014059 regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P63141-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04447-1", "uniprot_id": [ { "id": "KCRB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04447", "type": "external" } ], "mass": 42713.0, "length": 381, "protein_name": "Creatine kinase B-type", "gene_name": "Ckb", "organism": "Mouse", "refseq_name": "creatine kinase B-type", "refseq_ac": [ { "id": "NP_067248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067248", "type": "external" } ], "gene_names_uniprotkb": "Ckb; Ckbb", "gene_names_refseq": "B-CK; Bck; CPK-B; Ck-3; Ck3; Ckbb; Ckb", "protein_names_uniprotkb": "Creatine kinase B-type; 2.7.3.2; B-CK; CPK-B; Creatine kinase B chain; Creatine phosphokinase B-type", "protein_names_refseq": "creatine kinase B chain; creatine kinase B-type; creatine phosphokinase B-type", "tax_id": 10090, "disease": "left ventricular failure (Disease Ontology:DOID:0051064)", "pathway": " (mmu:12709); (R-MMU-71288); (R-MMU-9696264)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "15648052;16452087;16800626;17148442;1740343;18034455;18566107;21183079;26740625;30084848;31219806;33300544;33597756;34428180;36288343;3641191;37507081;38272036", "class_list": "", "function": "Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB., [RefSeq, PubMed]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:33597756). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (PubMed:33597756). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (PubMed:33597756)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQP4;Q3TKI3;Q3U5P5;Q3UF71;Q9CXK6", "ec_number_list": [ { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0030644 intracellular chloride ion homeostasis;GO:0140651 futile creatine cycle", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q04447-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62315-1", "uniprot_id": [ { "id": "JARD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62315", "type": "external" } ], "mass": 137445.0, "length": 1234, "protein_name": "Protein Jumonji", "gene_name": "Jarid2", "organism": "Mouse", "refseq_name": "protein Jumonji isoform 1", "refseq_ac": [ { "id": "NP_001191972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191972", "type": "external" } ], "gene_names_uniprotkb": "Jarid2; Jmj", "gene_names_refseq": "Jarid2; Jmj; jumonji", "protein_names_uniprotkb": "Protein Jumonji; Jumonji/ARID domain-containing protein 2", "protein_names_refseq": "jumonji, AT rich interactive domain 2; jumonji/ARID domain-containing protein 2; protein Jumonji isoform 1", "tax_id": 10090, "disease": "autistic disorder (Disease Ontology:DOID:12849); aortic valve stenosis (Disease Ontology:DOID:1712)", "pathway": " (mmu:16468); (R-MMU-212300)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10446263;10807864;10913339;12852854;12890668;15542826;15870077;17521633;19010785;19455710;20064375;20064376;20075857;21750661;26523946;31914400;34428180;36210013;38394221;7758946;9376320", "class_list": "", "function": "MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPU4;Q3UHS7;Q99LD1", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008134 transcription factor binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0000785 chromatin;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q62315-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8J7-1", "uniprot_id": [ { "id": "KCRS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8J7", "type": "external" } ], "mass": 47473.0, "length": 419, "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "Ckmt2", "organism": "Mouse", "refseq_name": "creatine kinase S-type, mitochondrial precursor", "refseq_ac": [ { "id": "NP_940807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940807", "type": "external" } ], "gene_names_uniprotkb": "Ckmt2", "gene_names_refseq": "2300008A19Rik; Ckmt2; S-MtCK; ScCKmit; mib-CK", "protein_names_uniprotkb": "Creatine kinase S-type, mitochondrial; 2.7.3.2; Basic-type mitochondrial creatine kinase; Mib-CK; S-MtCK; Sarcomeric mitochondrial creatine kinase", "protein_names_refseq": "basic-type mitochondrial creatine kinase; creatine kinase S-type, mitochondrial precursor; creatine kinase S-type, mitochondrial; sarcomeric mitochondrial creatine kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:76722); (R-MMU-71288)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;27802388;29509881;33300544;34428180;36288343;37507081;38956325;39383244;39927985", "class_list": "", "function": "Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes., [RefSeq, PubMed]; Modest elevation of MtCK activity in the heart does not adversely affect cellular metabolism, mitochondrial or in vivo cardiac function, but modifies mPTP opening to protect against I/R injury and improve functional recovery., [RefSeq, PubMed]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0006603 phosphocreatine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6P8J7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V64-1", "uniprot_id": [ { "id": "ISOC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V64", "type": "external" } ], "mass": 32033.0, "length": 297, "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "Isoc1", "organism": "Mouse", "refseq_name": "isochorismatase domain-containing protein 1", "refseq_ac": [ { "id": "NP_079754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079754", "type": "external" } ], "gene_names_uniprotkb": "Isoc1", "gene_names_refseq": "2610034N03Rik; Isoc1", "protein_names_uniprotkb": "Isochorismatase domain-containing protein 1", "protein_names_refseq": "isochorismatase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66307)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12198563;21750661;23806337;28135057", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U677", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91V64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z329-1", "uniprot_id": [ { "id": "ITPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z329", "type": "external" } ], "mass": 307475.0, "length": 2701, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "gene_name": "Itpr2", "organism": "Mouse", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform 2", "refseq_ac": [ { "id": "NP_034716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034716", "type": "external" } ], "gene_names_uniprotkb": "Itpr2; Itpr5", "gene_names_refseq": "InsP3R-2; InsP3R-5; Ip3r2; Itpr2; Itpr5; insP3R2", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; IP3 receptor isoform 2; IP3R 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate type V receptor; InsP3R2; Type 2 InsP3 receptor; Type 2 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "IP3 receptor; IP3R 2; inositol 1,4,5-triphosphate receptor 5; inositol 1,4,5-trisphosphate receptor type 2; inositol 1,4,5-trisphosphate type V receptor; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform 2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; inositol trisphosphate receptor type 2; type 2 InsP3 receptor; type 2 inositol 1,4,5-trisphosphate receptor", "tax_id": 10090, "disease": "isolated anhidrosis with normal sweat glands (Disease Ontology:DOID:0060603); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16439); (R-MMU-114508); (R-MMU-139853); (R-MMU-381676); (R-MMU-5578775); (R-MMU-983695)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;15632133;17242355;19608738;20189985;20485683;21183079;21750661;22547632;25329695;25428506;30084848;34428180;36210013;40997131;8063813;9065779;9729462", "class_list": "", "function": "Has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity., [UniProtKB, PubMed]; Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed:15632133, PubMed:19608738, PubMed:20189985, PubMed:22547632, PubMed:25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (PubMed:22547632)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2KF91;P70226;Q5DWM3;Q5DWM5;Q61744;Q8R3B0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030424 axon", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia;GO:0006816 calcium ion transport;GO:0071361 cellular response to ethanol;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9Z329-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97367-1", "uniprot_id": [ { "id": "MEIS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97367", "type": "external" } ], "mass": 51728.0, "length": 477, "protein_name": "Homeobox protein Meis2", "gene_name": "Meis2", "organism": "Mouse", "refseq_name": "homeobox protein Meis2 isoform 1", "refseq_ac": [ { "id": "NP_001129544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129544", "type": "external" } ], "gene_names_uniprotkb": "Meis2; Mrg1; Stra10", "gene_names_refseq": "A430109D20Rik; Meis2; Mrg1; Stra10", "protein_names_uniprotkb": "Homeobox protein Meis2; Meis1-related protein 1", "protein_names_refseq": "Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2; homeobox protein Meis2 isoform 1; homeobox protein Meis2; meis1-related protein 1; myeloid ecotropic viral integration site-related gene 1", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); orofacial cleft (Disease Ontology:DOID:0050567); cleft palate, cardiac defects, and intellectual disability (Disease Ontology:DOID:0111697); open-angle glaucoma (Disease Ontology:DOID:1067); leukemia (Disease Ontology:DOID:1240); brain infarction (Disease Ontology:DOID:3454); cleft palate (Disease Ontology:DOID:674); learning disability (Disease Ontology:DOID:8927)", "pathway": " (mmu:17536)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10842069;11279116;11438208;15617687;17178831;21059917;21750661;8950991;9049632;9337137;9710595", "class_list": "", "function": "Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35676;O35677;P97403;P97404", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008134 transcription factor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning;GO:0045931 positive regulation of mitotic cell cycle;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97367-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62074-1", "uniprot_id": [ { "id": "KPCI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62074", "type": "external" } ], "mass": 68203.0, "length": 595, "protein_name": "Protein kinase C iota type", "gene_name": "Prkci", "organism": "Mouse", "refseq_name": "protein kinase C iota type isoform 1", "refseq_ac": [ { "id": "NP_032883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032883", "type": "external" } ], "gene_names_uniprotkb": "Prkci; Pkcl", "gene_names_refseq": "2310021H13Rik; PKClambda; Pkci; Pkcl; Prkci; Prkcl; aPKClambda; mKIAA4165", "protein_names_uniprotkb": "Protein kinase C iota type; 2.7.11.13; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; nPKC-iota", "protein_names_refseq": "aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; protein kinase C iota type isoform 1; protein kinase C iota type; protein kinase C, lambda", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); ovarian carcinoma (Disease Ontology:DOID:4001); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18759); (R-MMU-1912408); (R-MMU-209543); (R-MMU-420029); (R-MMU-9755511)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10934474;12813044;12832475;14615604;15322187;16267237;16792529;17242355;17313651;20399730;21183079;21750661;22579248;25153642;37828378;7513693;9971737", "class_list": "", "function": "Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis (By similarity). Downstream of PI3K is required for insulin-stimulated glucose transport. Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes. Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0035089 establishment of apical/basal cell polarity;GO:0006468 protein phosphorylation;GO:0007015 actin filament organization;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q62074-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18653-1", "uniprot_id": [ { "id": "KS6A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P18653", "type": "external" } ], "mass": 81595.0, "length": 724, "protein_name": "Ribosomal protein S6 kinase alpha-1", "gene_name": "Rps6ka1", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase alpha-1 isoform b", "refseq_ac": [ { "id": "NP_001272434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272434", "type": "external" } ], "gene_names_uniprotkb": "Rps6ka1; Mapkapk1a; Rsk1", "gene_names_refseq": "Mapkapk-1a; Rps6ka1; Rsk-1; Rsk1; Rsk; S6K-alpha-1; p90-Rsk1; p90Rsk1; p90S6K; p90rsk", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-1; 2.7.11.1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1; Ribosomal S6 kinase 1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K", "protein_names_refseq": "90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase alpha-1 isoform b; ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1", "tax_id": 10090, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (mmu:20111); (R-MMU-198753); (R-MMU-199920); (R-MMU-2559582); (R-MMU-442742); (R-MMU-444257); (R-MMU-881907); (R-MMU-9856649)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10635333;17242355;19144319;21183079;21750661;22041125;2779569;28528544;30586719;32581239;32848054;34428180;34678516;35820727;39627609", "class_list": "", "function": "Combination antiretroviral therapy increased monocyte/macrophage sensitivity to reactive oxygen species- in HIV(+) individuals by suppressing NRF2-ARE activity via p90RSK-mediated ERK5 S496 phosphorylation, which coordinately elicited senescent phenotypes and proinflammatory responses, [RefSeq, PubMed]; MTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (By similarity). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (By similarity). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (By similarity). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (By similarity). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (By similarity). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (By similarity). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (By similarity). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:10635333). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (By similarity). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P18653-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35671-1", "uniprot_id": [ { "id": "ITBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35671", "type": "external" } ], "mass": 21644.0, "length": 200, "protein_name": "Integrin beta-1-binding protein 1", "gene_name": "Itgb1bp1", "organism": "Mouse", "refseq_name": "integrin beta-1-binding protein 1", "refseq_ac": [ { "id": "NP_032429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032429", "type": "external" } ], "gene_names_uniprotkb": "Itgb1bp1", "gene_names_refseq": "Icap1; Itgb1bp1", "protein_names_uniprotkb": "Integrin beta-1-binding protein 1; Bodenin", "protein_names_refseq": "bodenin; integrin beta-1-binding protein 1; integrin cytoplasmic domain-associated protein 1", "tax_id": 10090, "disease": "melanoma (Disease Ontology:DOID:1909)", "pathway": " (mmu:16413)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16741948;17567669;17654484;18227284;21183079;21750661;21768292;23720740;23918940;28049720;34428180;35491946;9626504", "class_list": "", "function": "Data show that phosphorylation of ICAP-1alpha by CaMKII controls beta1 integrin activation and cell adhesion., [RefSeq, PubMed]; ICAP-1 loss impairs CD8(+) thymocyte development and leads to reduced marginal zone B cells in mice., [RefSeq, PubMed]; ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility. Erratum:[J Cell Sci. 2017 Mar 15;130(6):1195. doi: 10.1242/jcs.202218. PMID: 28298614], [RefSeq, PubMed]; ICAP-1 promotes differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state., [RefSeq, PubMed]; ICAP-1 regulates beta1 integrin-dependent cell migration by affecting the pattern of focal adhesion formation., [RefSeq, PubMed]; Integrin cytoplasmic domain-associated protein-1 (ICAP-1) binds ROCK to beta1 integrin at the cell membrane (ICAP-1), [RefSeq, PubMed]; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The CCM1 loss resulted in ICAP-1 destabilization, which increased beta1 integrin activation and led to increased RhoA-dependent contractility., [RefSeq, PubMed]; The ICAP-1 works in concert with kindlin-2 to control the dynamics of beta1 integrin-containing fibrillar adhesions and, thereby, regulates fibronectin deposition and osteoblast mineralization. Erratum:[J Cell Biol. 2013 May 13;201(4):643], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542A8", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0010764 negative regulation of fibroblast migration;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35671-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148V7-1", "uniprot_id": [ { "id": "RELCH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q148V7", "type": "external" } ], "mass": 134587.0, "length": 1216, "protein_name": "RAB11-binding protein RELCH", "gene_name": "Relch", "organism": "Mouse", "refseq_name": "RAB11-binding protein RELCH isoform 2", "refseq_ac": [ { "id": "NP_083625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083625", "type": "external" } ], "gene_names_uniprotkb": "Relch; 2310035C23Rik; Kiaa1468", "gene_names_refseq": "2310035C23Rik; 6430401N10; Kiaa1468; Relch; mKIAA1468", "protein_names_uniprotkb": "RAB11-binding protein RELCH; LisH domain and HEAT repeat-containing protein KIAA1468; RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats", "protein_names_refseq": "RAB11-binding protein RELCH isoform 2; RAB11-binding protein RELCH; RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats", "tax_id": 10090, "disease": "", "pathway": " (mmu:227446)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;21952136;25428506;29514919;30084848;30779550;30899004;31219806;32848054;34428180;35820727;35822049;40885482", "class_list": "", "function": "Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data suggest that RELCH promotes nonvesicular cholesterol transport from recycling endosomes to the trans-Golgi network through membrane tethering., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q148V6;Q6PAN5;Q6ZPQ2;Q8C9Z0;Q8CCT3;Q8CD48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0055037 recycling endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0032367 intracellular cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q148V7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZJ6-1", "uniprot_id": [ { "id": "MFAP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZJ6", "type": "external" } ], "mass": 18538.0, "length": 164, "protein_name": "Microfibrillar-associated protein 5", "gene_name": "Mfap5", "organism": "Mouse", "refseq_name": "microfibrillar-associated protein 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_056591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056591", "type": "external" } ], "gene_names_uniprotkb": "Mfap5; Magp2", "gene_names_refseq": "MAGP-2; MFAP-5; Mfap5", "protein_names_uniprotkb": "Microfibrillar-associated protein 5; MAGP-2; MFAP-5; Microfibril-associated glycoprotein 2", "protein_names_refseq": "microfibril-associated glycoprotein 2; microfibrillar-associated protein 5 isoform 1 precursor", "tax_id": 10090, "disease": "thoracic aortic aneurysm (Disease Ontology:DOID:14004)", "pathway": " (mmu:50530); (R-MMU-1566948); (R-MMU-2129379)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10723723;12122015;15022335;21750661;23963447;36934797;37253753;37569268;38348695", "class_list": "", "function": "Interaction with fibrillin-1 and fibrillin-2 suggesting role in elastic fiber assembly, [RefSeq, PubMed]; MAGP2 promotes osteogenic differentiation during fracture healing through its crosstalk with the beta-catenin pathway., [RefSeq, PubMed]; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (PubMed:23963447). Component of the elastin-associated microfibrils (By similarity)., [UniProtKB, UniProtKB, PubMed]; Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin alphavbeta3/PTK2/AKT Signaling., [RefSeq, PubMed]; Microfibril-associated protein 5 and the regulation of skin scar formation. Publication Status: Online-Only, [RefSeq, PubMed]; Tight skin fibrillin 1 altered extracellular matrix organization and caused fibrosis by affecting deposition of MAGP-2 or other fibrillin-1-associated proteins., [RefSeq, PubMed]; Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030023 extracellular matrix constituent conferring elasticity", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0048048 embryonic eye morphogenesis;GO:0060216 definitive hemopoiesis;GO:0097435 supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTN8-1", "uniprot_id": [ { "id": "JKIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTN8", "type": "external" } ], "mass": 98715.0, "length": 844, "protein_name": "Janus kinase and microtubule-interacting protein 3", "gene_name": "Jakmip3", "organism": "Mouse", "refseq_name": "janus kinase and microtubule-interacting protein 3 isoform 1", "refseq_ac": [ { "id": "NP_082984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082984", "type": "external" } ], "gene_names_uniprotkb": "Jakmip3; Kiaa4091; Necc2", "gene_names_refseq": "6330417G02Rik; Jakmip3; mKIAA4091", "protein_names_uniprotkb": "Janus kinase and microtubule-interacting protein 3; Neuroendocrine long coiled-coil protein 2", "protein_names_refseq": "janus kinase and microtubule-interacting protein 3 isoform 1; neuroendocrine long coiled-coil protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74004)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17572408;21183079;21750661;29187734;38461872", "class_list": "", "function": "The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E [-/-] mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDR4;Q0VDR5;Q9CU41", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5DTN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921M4-1", "uniprot_id": [ { "id": "GOGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921M4", "type": "external" } ], "mass": 113278.0, "length": 999, "protein_name": "Golgin subfamily A member 2", "gene_name": "Golga2", "organism": "Mouse", "refseq_name": "golgin subfamily A member 2 isoform b", "refseq_ac": [ { "id": "NP_001074437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074437", "type": "external" } ], "gene_names_uniprotkb": "Golga2", "gene_names_refseq": "GM130; Golga2", "protein_names_uniprotkb": "Golgin subfamily A member 2; 130 kDa cis-Golgi matrix protein; GM130", "protein_names_refseq": "130 kDa cis-Golgi matrix protein; SY11 protein; golgi autoantigen, golgin subfamily a, 2; golgin subfamily A member 2 isoform b; golgin subfamily A member 2; golgin-95", "tax_id": 10090, "disease": "", "pathway": " (mmu:99412); (R-MMU-162658); (R-MMU-204005); (R-MMU-6807878)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "21183079;21552007;21750661;26165940;26742501;28028212;28617811;30779550;31219806;34418053;34428180;36210013", "class_list": "", "function": "Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (PubMed:28028212). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (PubMed:28028212). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis. Also plays a key role in spindle pole assembly and centrosome organization (By similarity). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (By similarity). Regulates the meiotic spindle pole assembly, probably via the same mechanism (PubMed:21552007). Also regulates the centrosome organization (By similarity). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AN43;A2AN47", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000922 spindle pole;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0051289 protein homotetramerization;GO:0090307 mitotic spindle assembly;GO:0009101 glycoprotein biosynthetic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q921M4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AXH1-1", "uniprot_id": [ { "id": "NHSL2_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AXH1", "type": "external" } ], "mass": 132353.0, "length": 1219, "protein_name": "NHS-like protein 2", "gene_name": "Nhsl2", "organism": "Mouse", "refseq_name": "NHS-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001157082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157082", "type": "external" } ], "gene_names_uniprotkb": "Nhsl2", "gene_names_refseq": "1110062M06Rik; 6430511F03; EG621083; Gm10456; Nhsl2", "protein_names_uniprotkb": "NHS-like protein 2", "protein_names_refseq": "NHS-like protein 2 isoform 1; NHS-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042480)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14691545;21183079;21750661;22645316;34428180;35822049;36210013", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0V6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "B1AXH1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30275-1", "uniprot_id": [ { "id": "KCRU_MOUSE", "url": "https://www.uniprot.org/uniprot/P30275", "type": "external" } ], "mass": 47004.0, "length": 418, "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "Ckmt1", "organism": "Mouse", "refseq_name": "creatine kinase U-type, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_034027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034027", "type": "external" } ], "gene_names_uniprotkb": "Ckmt1", "gene_names_refseq": "Ckmt1; Mt-CK; ScCKmit; U-MtCK; UbCKmit; mi-CK; mia-CK", "protein_names_uniprotkb": "Creatine kinase U-type, mitochondrial; 2.7.3.2; Acidic-type mitochondrial creatine kinase; Mia-CK; U-MtCK; Ubiquitous mitochondrial creatine kinase", "protein_names_refseq": "acidic-type mitochondrial creatine kinase; creatine kinase U-type, mitochondrial isoform 1 precursor; creatine kinase U-type, mitochondrial; ubiquitous mitochondrial creatine kinase", "tax_id": 10090, "disease": "status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:12716); (R-MMU-71288)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;21750661;29753758;30084848;33300544;34428180;37954502;38720063;40684658;7598809", "class_list": "", "function": "Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanistic studies showed lncRNA n335586 promoted hepatocellular carcinoma (HCC) cells migration and invasion through facilitating the expression of its host gene mitochondrial creatine kinase (CKMT1A) by competitively binding miR-924. Erratum:[Cancer Lett. 2020 Dec 1;494:84-87. doi: 10.1016/j.canlet.2020.07.018. PMID: 32911100], [RefSeq, PubMed]; Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease., [RefSeq, PubMed]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043204 perikaryon;GO:0043209 myelin sheath;GO:0044289 mitochondrial inner-outer membrane contact site", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0043066 negative regulation of apoptotic process;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P30275-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924H2-1", "uniprot_id": [ { "id": "MED15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924H2", "type": "external" } ], "mass": 86607.0, "length": 789, "protein_name": "Mediator of RNA polymerase II transcription subunit 15", "gene_name": "Med15", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 15 isoform a", "refseq_ac": [ { "id": "NP_291087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291087", "type": "external" } ], "gene_names_uniprotkb": "Med15; MED15; Pcqap", "gene_names_refseq": "A230074L19Rik; Med15; Pcqap; mPcqap", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 15; Mediator complex subunit 15; PC2 glutamine/Q-rich-associated protein; Positive cofactor 2 glutamine/Q-rich-associated protein; mPcqap", "protein_names_refseq": "PC2 glutamine/Q-rich-associated protein; mediator of RNA polymerase II transcription subunit 15 isoform a; mediator of RNA polymerase II transcription subunit 15; positive cofactor 2 glutamine/Q-rich-associated protein; positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein", "tax_id": 10090, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:94112)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11414760;21183079;21606357;21750661;24129315;31219806;40997131", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X8S4", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0019827 stem cell population maintenance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q924H2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERH7-1", "uniprot_id": [ { "id": "HIPK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERH7", "type": "external" } ], "mass": 130081.0, "length": 1192, "protein_name": "Homeodomain-interacting protein kinase 3", "gene_name": "Hipk3", "organism": "Mouse", "refseq_name": "homeodomain-interacting protein kinase 3 isoform 1", "refseq_ac": [ { "id": "NP_034564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034564", "type": "external" } ], "gene_names_uniprotkb": "Hipk3; Fist3", "gene_names_refseq": "DYRK6; FIST3; Hipk3; PKY; mir-1902", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 3; 2.7.11.1; ANPK; Androgen receptor-interacting nuclear protein kinase; FIST; Fas-interacting serine/threonine-protein kinase; Nbak3; Nuclear body-associated kinase 3", "protein_names_refseq": "ANPK; FIST; HCMV-interacting protein; androgen receptor-interacting nuclear protein kinase; fas-interacting serine/threonine-protein kinase; homeodomain-interacting protein kinase 3 isoform 1; nbak3; nuclear body-associated kinase 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:15259)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11034606;17210646;18034455;20484411;21183079;21750661;34239356;35467292;35716032;36438474;9725910;9748262", "class_list": "", "function": "CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis., [RefSeq, PubMed]; CircHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR. Publication Status: Online-Only, [RefSeq, PubMed]; CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2., [RefSeq, PubMed]; CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQH2;O88906;Q9QZR2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0018107 peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ERH7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38647-1", "uniprot_id": [ { "id": "HSPA9_MOUSE", "url": "https://www.uniprot.org/uniprot/P38647", "type": "external" } ], "mass": 73461.0, "length": 679, "protein_name": "Stress-70 protein, mitochondrial", "gene_name": "Hspa9", "organism": "Mouse", "refseq_name": "stress-70 protein, mitochondrial", "refseq_ac": [ { "id": "NP_034611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034611", "type": "external" } ], "gene_names_uniprotkb": "Hspa9; Grp75; Hsp74; Hspa9a", "gene_names_refseq": "74kDa; Csa; Grp75; Hsc74; Hsp74a; Hsp74; Hspa9a; Hspa9; Mortalin; Mot-2; Mot2; Mthsp70; Pbp74", "protein_names_uniprotkb": "Stress-70 protein, mitochondrial; 3.6.4.10; 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; PBP74; Peptide-binding protein 74; p66 MOT", "protein_names_refseq": "75 kDa glucose-regulated protein; C3H-specific antigen; GRP-75; heat shock 70 kDa protein 9; heat shock protein 9A; heat shock protein cognate 74; heat shock protein, 74 kDa, A; heat shock protein, A; p66 MOT; peptide-binding protein 74; stress-70 protein, mitochondrial", "tax_id": 10090, "disease": "autosomal dominant sideroblastic anemia 4 (Disease Ontology:DOID:0060335); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:15526); (R-MMU-3371453); (R-MMU-6799198); (R-MMU-9837999); (R-MMU-9865881)", "pathway_count": 5, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;21123823;23576753;23806337;24243970;25428506;25605945;26495903;26702583;26740625;27014269;29187734;29907098;31219806;34260942;34428180;34887587;36064721;36288343;37453647;37507081;37828378;38192280;38467701;39627609;39927985;7523108;7684501;7692847;7693662;7865888;8262211;8454632", "class_list": "", "function": "HSPA9 reduction exacerbates symptoms and cell death in DSS-Induced inflammatory colitis. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones. In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis (PubMed:26702583). Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:21123823). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (PubMed:29907098). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (By similarity). May play a role in the control of cell proliferation and cellular aging (PubMed:21123823, PubMed:26702583, PubMed:8454632). Protects against reactive oxygen species (ROS) (PubMed:24243970). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW93;Q3UVN1;Q3V015;Q7TSZ0;Q9CQ05", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": 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"https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0030218 erythrocyte differentiation;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P38647-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63017-1", "uniprot_id": [ { "id": "HSP7C_MOUSE", "url": "https://www.uniprot.org/uniprot/P63017", "type": "external" } ], "mass": 70871.0, "length": 646, "protein_name": "Heat shock cognate 71 kDa protein", "gene_name": "Hspa8", "organism": "Mouse", "refseq_name": "heat shock cognate 71 kDa protein isoform 1", "refseq_ac": [ { "id": "NP_112442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112442", "type": "external" } ], "gene_names_uniprotkb": "Hspa8; Hsc70; Hsc73", "gene_names_refseq": "2410008N15Rik; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; Hspa8", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein; 3.6.4.10; Heat shock 70 kDa protein 8", "protein_names_refseq": "heat shock 70 kDa protein 8; heat shock cognate 71 kDa protein isoform 1; heat shock cognate 71 kDa protein; heat shock cognate hsc73; heat shock protein 8; heat shock protein cognate 70", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); graft-versus-host disease (Disease Ontology:DOID:0081267); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:15481); (R-MMU-3371453); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-432720); (R-MMU-432722); (R-MMU-450408); (R-MMU-6798695); (R-MMU-72163); (R-MMU-8856828); (R-MMU-8876725); (R-MMU-888590); (R-MMU-9833482)", "pathway_count": 14, "publication_count": 40, "publication_id_list": "10.1101/2023.09.13.557529;10095055;15292236;16075062;16139798;17233114;17322886;20060297;21502331;21750661;2251119;22645316;23806337;23921388;24129315;25428506;25605945;26495903;30016717;30084848;30718432;30779550;31219806;33300544;3334718;33725478;34203471;34428180;34887587;35984892;36288343;37453647;37507081;37828378;38454159;39627609;39927985;8245790;8682318;9675148", "class_list": "", "function": "BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation (PubMed:30718432). Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:30718432). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:30718432). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0031686 A1 adenosine receptor binding;GO:0055131 C3HC4-type RING finger domain binding;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031906 late endosome lumen;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0044829 host-mediated activation of viral genome replication;GO:0061684 chaperone-mediated autophagy;GO:0061738 late endosomal microautophagy;GO:1902904 negative regulation of supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P63017-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70174-1", "uniprot_id": [ { "id": "HRH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70174", "type": "external" } ], "mass": 55682.0, "length": 488, "protein_name": "Histamine H1 receptor", "gene_name": "Hrh1", "organism": "Mouse", "refseq_name": "histamine H1 receptor", "refseq_ac": [ { "id": "NP_001239571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239571", "type": "external" } ], "gene_names_uniprotkb": "Hrh1; Bphs", "gene_names_refseq": "Bphs; H1R; HH1R; Hir; Hrh1", "protein_names_uniprotkb": "Histamine H1 receptor; H1R; HH1R", "protein_names_refseq": "Bordetella pertussis induced histamine sensitization; histamine H1 receptor", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:15465); (R-MMU-390650); (R-MMU-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12142541;12595443;17145090;21183079;21750661;24709960;30084848;38712635;8812432;8917588", "class_list": "", "function": "Comprehensive mapping of histamine H1 receptor mRNA in the mouse brain., [RefSeq, PubMed]; G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (By similarity). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules (PubMed:12595443). Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (PubMed:17145090, PubMed:8917588)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91V75;Q91XN0;Q91XN1;Q91XN2;Q91XN3", "ec_number_list": [], "go_molecular_function": "GO:0004969 histamine receptor activity;GO:0015085 calcium ion transmembrane transporter activity;GO:0051381 histamine binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0008542 visual learning;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70174-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZJ2-1", "uniprot_id": [ { "id": "HS12B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZJ2", "type": "external" } ], "mass": 76119.0, "length": 685, "protein_name": "Heat shock 70 kDa protein 12B", "gene_name": "Hspa12b", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 12B", "refseq_ac": [ { "id": "NP_082582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082582", "type": "external" } ], "gene_names_uniprotkb": "Hspa12b", "gene_names_refseq": "2700081N06Rik; Hspa12b", "protein_names_uniprotkb": "Heat shock 70 kDa protein 12B", "protein_names_refseq": "heat shock 70 kDa protein 12B; heat shock protein 12B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72630); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12552099;17242355;21183079;21750661;23729663;24977412;32411123;32457753;32790647;36256626;37507081", "class_list": "", "function": "Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; HSPA12A and HSPA12B may play roles in genetic susceptibility to atherosclerosis, [RefSeq, PubMed]; Inhibition of eNOS abrogated the protection of HSPA12B against cardiac dysfunction and remodelling after myocardial infarction, [RefSeq, PubMed]; LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS., [RefSeq, PubMed]; Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Plasma extracellular HSPA12B is elevated in both septic mice and patients. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0001525 angiogenesis;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CZJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TBD2-1", "uniprot_id": [ { "id": "HMHA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TBD2", "type": "external" } ], "mass": 122902.0, "length": 1116, "protein_name": "Rho GTPase-activating protein 45", "gene_name": "Arhgap45", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 45 isoform 1", "refseq_ac": [ { "id": "NP_001136173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136173", "type": "external" } ], "gene_names_uniprotkb": "Arhgap45; Hmha1", "gene_names_refseq": "6330406L22Rik; Arhgap45; Ha-1; Hmha1", "protein_names_uniprotkb": "Rho GTPase-activating protein 45; Minor histocompatibility protein HA-1", "protein_names_refseq": "histocompatibility (minor) HA-1; minor histocompatibility protein HA-1; rho GTPase-activating protein 45 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70719); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "16774541;17242355;19144319;21183079;21750661;24129315;29187734;31219806;33725478;34418053;39627609", "class_list": "", "function": "Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDD2;Q3TSW0;Q3TXM6;Q3UZ72;Q8BI83;Q9CU46", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3TBD2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61699-1", "uniprot_id": [ { "id": "HS105_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61699", "type": "external" } ], "mass": 96407.0, "length": 858, "protein_name": "Heat shock protein 105 kDa", "gene_name": "Hsph1", "organism": "Mouse", "refseq_name": "heat shock protein 105 kDa isoform 2", "refseq_ac": [ { "id": "NP_001334463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334463", "type": "external" } ], "gene_names_uniprotkb": "Hsph1; Hsp105; Hsp110; Kiaa0201", "gene_names_refseq": "105kDa; Hsp105; Hsp110; Hsph1; hsp-E7I; hsp110/105", "protein_names_uniprotkb": "Heat shock protein 105 kDa; 42 degrees C-HSP; HSP-E7I; Heat shock 110 kDa protein; Heat shock-related 100 kDa protein E7I", "protein_names_refseq": "42 degrees C-HSP; HSP105 42 C-HSP; heat shock 110 kDa protein; heat shock protein 105 kDa isoform 2; heat shock protein 105 kDa; heat shock protein 110; heat shock-related 100 kDa protein E7I", "tax_id": 10090, "disease": "", "pathway": " (mmu:15505); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10066425;10772927;10865058;12558502;14644449;15292236;15345747;16232202;19131326;19144319;21183079;21750661;23806337;28580422;31173393;31219806;34428180;34887587;35986277;37453647;37507081;37648554;39627609;7556594;8530361;9675148", "class_list": "", "function": "Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236)., [UniProtKB, UniProtKB, PubMed, PubMed]; HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-kappaB pathway., [RefSeq, PubMed]; Hsp105alpha suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation., [RefSeq, PubMed]; Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; These observations suggest that GGA administration is a therapeutic candidate for depressive diseases by increasing hippocampal BDNF levels via HSP105 expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNS2;Q3UIY8;Q62578;Q62579;Q6A0A5;Q8C430;Q8VCW6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043014 alpha-tubulin binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903748 negative regulation of establishment of protein localization to mitochondrion;GO:0051135 positive regulation of NK T cell activation;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061098 positive regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q61699-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6EAL8-1", "uniprot_id": [ { "id": "IL31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6EAL8", "type": "external" } ], "mass": 18120.0, "length": 163, "protein_name": "Interleukin-31", "gene_name": "Il31", "organism": "Mouse", "refseq_name": "interleukin-31 isoform 1 precursor", "refseq_ac": [ { "id": "NP_083870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083870", "type": "external" } ], "gene_names_uniprotkb": "Il31", "gene_names_refseq": "1700013B14Rik; Il31", "protein_names_uniprotkb": "Interleukin-31; IL-31", "protein_names_refseq": "IL-31; interleukin-31 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:76399); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15184896;17353366;17379091;19054054;19414760;21750661;25847241;32673566;33819507;36680936;37831760", "class_list": "", "function": "-31 antibody reduces scratching behaviour in an atopic dermatitis-like murine model during the onset of clinical skin manifestations, [RefSeq, PubMed]; Adenosine induces IL-31 secretion by T-helper 2 cells: Implication for the effect of adenosine on atopic dermatitis and its therapeutic strategy., [RefSeq, PubMed]; Functions as a cytokine that binds to IL31RA, a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) (By similarity). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding to IL31RA, induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated. In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). Enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and serum amyloid A protein expression in macrophages (PubMed:25847241)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung., [RefSeq, PubMed]; IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases Erratum:[Nat Immunol. 2005 Jan;6(1):114], [RefSeq, PubMed]; IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis., [RefSeq, PubMed]; Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound., [RefSeq, PubMed]; The Cytokine TGF-beta Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching., [RefSeq, PubMed]; These data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005147 oncostatin-M receptor binding;GO:0005125 cytokine activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6EAL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEK6-1", "uniprot_id": [ { "id": "ING3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEK6", "type": "external" } ], "mass": 46847.0, "length": 421, "protein_name": "Inhibitor of growth protein 3", "gene_name": "Ing3", "organism": "Mouse", "refseq_name": "inhibitor of growth protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001297990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297990", "type": "external" } ], "gene_names_uniprotkb": "Ing3", "gene_names_refseq": "1300013A07Rik; Ing3; P47ING3", "protein_names_uniprotkb": "Inhibitor of growth protein 3; p47ING3", "protein_names_refseq": "inhibitor of growth protein 3 isoform 2; inhibitor of growth protein 3; p47 regulator protein", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:71777)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23806337;25819753", "class_list": "", "function": "Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB]; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JS6;Q9ERB2", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0032777 piccolo histone acetyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process;GO:0051726 regulation of cell cycle;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VEK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YJ5-1", "uniprot_id": [ { "id": "IF2M_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YJ5", "type": "external" } ], "mass": 81289.0, "length": 727, "protein_name": "Translation initiation factor IF-2, mitochondrial", "gene_name": "Mtif2", "organism": "Mouse", "refseq_name": "translation initiation factor IF-2, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_001269047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269047", "type": "external" } ], "gene_names_uniprotkb": "Mtif2", "gene_names_refseq": "2310038D14Rik; 2410112O06Rik; IF-2(Mt); IF-2mt; IF2(mt); Mtif2", "protein_names_uniprotkb": "Translation initiation factor IF-2, mitochondrial; IF-2(Mt); IF-2Mt; IF2(mt)", "protein_names_refseq": "translation initiation factor IF-2, mitochondrial isoform 1 precursor; translation initiation factor IF-2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:76784)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15378723;21750661", "class_list": "", "function": "Mitochondrial translation initiation factor that promotes binding of formylmethionyl-tRNA to the 30S ribosomal subunits (By similarity). Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M6W6", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043024 ribosomal small subunit binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070124 mitochondrial translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91YJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50096-1", "uniprot_id": [ { "id": "IMDH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P50096", "type": "external" } ], "mass": 55279.0, "length": 514, "protein_name": "Inosine-5'-monophosphate dehydrogenase 1", "gene_name": "Impdh1", "organism": "Mouse", "refseq_name": "inosine-5'-monophosphate dehydrogenase 1 isoform 1", "refseq_ac": [ { "id": "NP_001289862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289862", "type": "external" } ], "gene_names_uniprotkb": "Impdh1; IMPDH", "gene_names_refseq": "B930086D20Rik; IMPDH-I; Impdh1", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 1; 1.1.1.205; IMP dehydrogenase 1; IMPD 1; IMPDH 1; IMPDH-I", "protein_names_refseq": "IMP dehydrogenase 1; IMPD 1; IMPDH 1; inosine 5'-phosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1 isoform 1; inosine-5'-monophosphate dehydrogenase 1", "tax_id": 10090, "disease": "Leber congenital amaurosis 11 (Disease Ontology:DOID:0110216); retinitis pigmentosa 10 (Disease Ontology:DOID:0110388); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:23917); (R-MMU-6798695); (R-MMU-73817); (R-MMU-9748787)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11875049;12944494;21750661;24129315;25428506;30084848;31838626;32254022;38733555;7690562", "class_list": "", "function": "A mutation in this isozyme of Rho-/- mice was revealed in comparfative microarray analysis to be a homologue of the putative enzyme in human autosomal dominant retinitis pigmentosa., [RefSeq, PubMed]; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions. Publication Status: Online-Only, [RefSeq, PubMed]; The Impact of Terminal Peptide Extensions of Retinal Inosine 5 Monophosphate Dehydrogenase 1 Isoforms on their DNA-binding Activities., [RefSeq, PubMed]; The functional impact of the C/N-terminal extensions of the mouse retinal IMPDH1 isoforms: a kinetic evaluation., [RefSeq, PubMed]; We conclude that both IMPDH and HPRT activities contribute to normal T-lymphocyte activation and function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046651 lymphocyte proliferation;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006183 GTP biosynthetic process;GO:0032263 GMP salvage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50096-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70168-1", "uniprot_id": [ { "id": "IMB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70168", "type": "external" } ], "mass": 97184.0, "length": 876, "protein_name": "Importin subunit beta-1", "gene_name": "Kpnb1", "organism": "Mouse", "refseq_name": "importin subunit beta-1", "refseq_ac": [ { "id": "NP_032405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032405", "type": "external" } ], "gene_names_uniprotkb": "Kpnb1; Impnb", "gene_names_refseq": "IPOB; Impnb; Kpnb1", "protein_names_uniprotkb": "Importin subunit beta-1; Karyopherin subunit beta-1; Nuclear factor p97; PTAC97; Pore targeting complex 97 kDa subunit; SCG", "protein_names_refseq": "PTAC97; SCG; importin beta; importin subunit beta-1; karyopherin (importin) beta 1; nuclear factor p97; pore targeting complex 97 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:16211); (R-MMU-140342); (R-MMU-1655829); (R-MMU-2995383); (R-MMU-6798695); (R-MMU-68616); (R-MMU-909733)", "pathway_count": 7, "publication_count": 30, "publication_id_list": "10964573;11493596;11535586;14645851;16452087;18299400;19224205;20173027;20484733;20699224;21952136;25428506;25605945;25946333;26495903;28011936;30084848;30779550;33300544;34203471;34428180;34887587;35794401;35820727;36288343;37453647;37828378;39627609;7635189;8812441", "class_list": "", "function": "Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:11493596). Acting autonomously, serves itself as NLS receptor (By similarity). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (By similarity). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In association with IPO7, mediates the nuclear import of H1 histone (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (PubMed:11493596). Imports MRTFA, SNAI1 and PRKCI into the nucleus (By similarity)., [UniProtKB, PubMed, UniProtKB]; KPNB1 modulates the Machado-Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62117;Q6GTI5", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007079 mitotic chromosome movement towards spindle pole;GO:0006610 ribosomal protein import into nucleus;GO:0090307 mitotic spindle assembly;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P70168-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMY8-1", "uniprot_id": [ { "id": "HUWE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMY8", "type": "external" } ], "mass": 482635.0, "length": 4377, "protein_name": "E3 ubiquitin-protein ligase HUWE1", "gene_name": "Huwe1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase HUWE1", "refseq_ac": [ { "id": "NP_067498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067498", "type": "external" } ], "gene_names_uniprotkb": "Huwe1; Kiaa0312; Ureb1", "gene_names_refseq": "5430439H10Rik; Arf-bp1; C430014N20Rik; Gm1718; Huwe1; Ib772; LASU1; Mule; Ureb1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HUWE1; 2.3.2.26; E3Histone; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; URE-B1; URE-binding protein 1; Upstream regulatory element-binding protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase HUWE1; E3Histone; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; Mcl-1 ubiquitin ligase; URE-B1; URE-binding protein 1; upstream regulatory element binding protein 1", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Turner type (Disease Ontology:DOID:0060811); non-syndromic X-linked intellectual disability 50 (Disease Ontology:DOID:0112029)", "pathway": " (mmu:59026); (R-MMU-6798695); (R-MMU-983168)", "pathway_count": 3, "publication_count": 38, "publication_id_list": "10.1101/2023.09.13.557529;15345747;15767685;15989956;16479539;17242355;17823942;18488021;19131326;20485683;20534529;21183079;21750661;22872234;23806337;24129315;25428506;25605945;29125738;29331071;30059200;30084848;30779550;31219806;32782141;32848054;33300544;34203471;34428180;35820727;36288343;36852467;37507081;37828378;38453366;39627609;40885482;40997131", "class_list": "", "function": "E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15767685, PubMed:18488021). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (By similarity). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (By similarity). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15767685). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (By similarity). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (By similarity). Mediates polyubiquitination of PA2G4 (By similarity). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquitination and degradation of NR1D1 (By similarity). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (By similarity). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (By similarity). Ubiquitinates PPARA in hepatocytes (PubMed:29331071)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 50, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "A2AFQ1;Q4G2Z1;Q5BMM7;Q6NS61;Q8BNJ7;Q8CFH2;Q8VD14;Q921M5;Q9R0P2", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0140852 histone ubiquitin ligase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0006284 base-excision repair;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q7TMY8-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D236-3", "uniprot_id": [ { "id": "HTRA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D236", "type": "external" } ], "mass": 49149.0, "length": 459, "protein_name": "Serine protease HTRA3", "gene_name": "Htra3", "organism": "Mouse", "refseq_name": "serine protease HTRA3 isoform b precursor", "refseq_ac": [ { "id": "NP_001036080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036080", "type": "external" } ], "gene_names_uniprotkb": "Htra3; Prsp; Tasp", "gene_names_refseq": "2210021K23Rik; 9530081K03Rik; Htra3; Prsp; Tasp", "protein_names_uniprotkb": "Serine protease HTRA3; 3.4.21.-; High-temperature requirement factor A3; Pregnancy-related serine protease; Toll-associated serine protease", "protein_names_refseq": "high-temperature requirement factor A3; pregnancy-related serine protease; probable serine protease HTRA3; serine protease HTRA3 isoform b precursor; toll-associated serine protease", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:78558)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12728021;15206957;15951015;25428506;28676687", "class_list": "", "function": "Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3., [RefSeq, PubMed]; Plays an important role in the formation/function of the placenta., [RefSeq, PubMed]; Results show that HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. Mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (PubMed:15206957). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRV0;Q6WLC5;Q6YDR0", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0030514 negative regulation of BMP signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D236-3", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4S8-1", "uniprot_id": [ { "id": "INT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P4S8", "type": "external" } ], "mass": 245168.0, "length": 2195, "protein_name": "Integrator complex subunit 1", "gene_name": "Ints1", "organism": "Mouse", "refseq_name": "integrator complex subunit 1", "refseq_ac": [ { "id": "NP_081024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081024", "type": "external" } ], "gene_names_uniprotkb": "Ints1", "gene_names_refseq": "1110015K06Rik; Ints1", "protein_names_uniprotkb": "Integrator complex subunit 1; Int1", "protein_names_refseq": "int1; integrator complex subunit 1", "tax_id": 10090, "disease": "neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies (Disease Ontology:DOID:0070346); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:68510); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17544522;21183079;21750661;26206133;30059200;30084848;31219806;34428180;35820727;36852467", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0KK58;Q80UQ7;Q91Z01;Q9CTF7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031965 nuclear membrane;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034474 U2 snRNA 3'-end processing;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0007566 embryo implantation;GO:0016180 snRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6P4S8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88310-1", "uniprot_id": [ { "id": "ITL1A_MOUSE", "url": "https://www.uniprot.org/uniprot/O88310", "type": "external" } ], "mass": 34953.0, "length": 313, "protein_name": "Intelectin-1a", "gene_name": "Itln1", "organism": "Mouse", "refseq_name": "intelectin-1a precursor", "refseq_ac": [ { "id": "NP_034714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034714", "type": "external" } ], "gene_names_uniprotkb": "Itln1; Intl; Itln1a; Itlna; Itln", "gene_names_refseq": "IntL; Itln1; Itln2; Itln3; Itln5; Itlna; Itln; Lfr", "protein_names_uniprotkb": "Intelectin-1a; Galactofuranose-binding lectin; Intestinal lactoferrin receptor", "protein_names_refseq": "calcium-dependent galactosyl-specific lectin; galactofuranose-binding lectin; intelectin 2; intelectin 5; intelectin a; intelectin-1a precursor; intelectin-1a; intestinal lactoferrin receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:16429); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14720597;15222482;15265922;16866365;16936804;17420014;17621593;21750661;26148048;37344704;37882238;38082368;38519941;9790983", "class_list": "glycogene", "function": "Activation of ITLN-1 attenuates oxidative stress injury via activating SIRT1/PGC1-alpha signaling in neuroblastoma cells., [RefSeq, PubMed]; Data show that the mouse lactoferrin receptor (MLfR) functions as a receptor for MLf, is expressed and localized in various tissues, and may be involved in the indispensable function of MLf during early embryonic development., [RefSeq, PubMed]; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind mammalian glycans. Probably plays a role in the defense system against microorganisms. May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (By similarity)., [UniProtKB, PubMed, UniProtKB]; Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7. Publication Status: Online-Only, [RefSeq, PubMed]; Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Strategic localization of intelectin at the enterocyte brush border suggests that trimeric intelectin serves as an organizer and stabilizer of the brush border membrane., [RefSeq, PubMed]; The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies. Publication Status: Online-Only, [RefSeq, PubMed]; These findings support the notion that until the development-dependent expression of DMT1 in the intestine is induced, mouse LfR may serve as an alternative iron uptake pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 100, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5IWS3", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043235 receptor complex;GO:0045121 membrane raft;GO:0031526 brush border membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0046326 positive regulation of D-glucose import;GO:0009624 response to nematode", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88310-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81067-1", "uniprot_id": [ { "id": "IRX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P81067", "type": "external" } ], "mass": 52693.0, "length": 507, "protein_name": "Iroquois-class homeodomain protein IRX-3", "gene_name": "Irx3", "organism": "Mouse", "refseq_name": "iroquois-class homeodomain protein IRX-3 isoform 1", "refseq_ac": [ { "id": "NP_001240751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240751", "type": "external" } ], "gene_names_uniprotkb": "Irx3; Irxb1", "gene_names_refseq": "Irx3", "protein_names_uniprotkb": "Iroquois-class homeodomain protein IRX-3; Homeodomain protein IRXB1; Iroquois homeobox protein 3", "protein_names_refseq": "homeodomain protein IRXB1; iroquois homeobox protein 3; iroquois-class homeodomain protein IRX-3 isoform 1; iroquois-class homeodomain protein IRX-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:16373)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10704856;10830170;10926765;15201216;17875669;21183079;24646999;9427753;9486539", "class_list": "", "function": "Transcription factor involved in SHH-dependent neural patterning (PubMed:10830170, PubMed:15201216). Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube (PubMed:10830170, PubMed:15201216). Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals (PubMed:10830170, PubMed:15201216). Involved in the transcriptional repression of MNX1 in non-motor neuron cells (PubMed:15201216). Acts as a regulator of energy metabolism (PubMed:24646999)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPZ3;Q5U3K8", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0072086 specification of loop of Henle identity;GO:0003167 atrioventricular bundle cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P81067-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81122-1", "uniprot_id": [ { "id": "IRS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P81122", "type": "external" } ], "mass": 136763.0, "length": 1321, "protein_name": "Insulin receptor substrate 2", "gene_name": "Irs2", "organism": "Mouse", "refseq_name": "insulin receptor substrate 2", "refseq_ac": [ { "id": "NP_001074681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074681", "type": "external" } ], "gene_names_uniprotkb": "Irs2", "gene_names_refseq": "Irs-2; Irs2", "protein_names_uniprotkb": "Insulin receptor substrate 2; 4PS; IRS-2", "protein_names_refseq": "4PS; insulin receptor substrate 2", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); osteoporosis (Disease Ontology:DOID:11476); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:384783); (R-MMU-109704); (R-MMU-112399); (R-MMU-112412); (R-MMU-1257604); (R-MMU-1266695); (R-MMU-198203); (R-MMU-2428928); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-74713); (R-MMU-74749); (R-MMU-8853659); (R-MMU-9006335); (R-MMU-9027276); (R-MMU-9027284)", "pathway_count": 16, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11018022;14557412;17636024;18034455;21183079;22645316;25830382;26657864;32782141;34203471;34428180;37550630;40021952;40885482;7675087;9495343", "class_list": "", "function": "Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:9495343, PubMed:25830382). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (By similarity). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation (PubMed:25830382). Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation. Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase. In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B9EJW3", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010631 epithelial cell migration;GO:1990859 cellular response to endothelin;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0032000 positive regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P81122-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3HNM7-1", "uniprot_id": [ { "id": "INSC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3HNM7", "type": "external" } ], "mass": 63615.0, "length": 579, "protein_name": "Protein inscuteable homolog", "gene_name": "Insc", "organism": "Mouse", "refseq_name": "protein inscuteable homolog isoform 2", "refseq_ac": [ { "id": "NP_776128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776128", "type": "external" } ], "gene_names_uniprotkb": "Insc", "gene_names_refseq": "3830422K02Rik; C730020D23; Insc", "protein_names_uniprotkb": "Protein inscuteable homolog; Minsc", "protein_names_refseq": "minsc; protein inscuteable homolog isoform 2; protein inscuteable homolog", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539)", "pathway": " (mmu:233752)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16094321;16301171;21750661;21816348;26694615;39218187", "class_list": "", "function": "Data (including data from studies using embryonic stem cell line) suggest that expression of Insc (inscuteable cell cycle protein) is up-regulated by c-Rel in cell differentiation; minimum transcriptional regulatory element (354 bases) was identified., [RefSeq, PubMed]; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis (PubMed:16301171, PubMed:21816348). May regulate cell proliferation and differentiation in the developing nervous system (PubMed:16301171). May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (PubMed:16094321)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTA5;Q8C7I7", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0005938 cell cortex", "go_biological_process": "GO:0009786 regulation of asymmetric cell division;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0031647 regulation of protein stability;GO:0008356 asymmetric cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3HNM7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDM4-1", "uniprot_id": [ { "id": "IHO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDM4", "type": "external" } ], "mass": 63340.0, "length": 574, "protein_name": "Interactor of HORMAD1 protein 1", "gene_name": "Iho1", "organism": "Mouse", "refseq_name": "interactor of HORMAD1 protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001128670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128670", "type": "external" } ], "gene_names_uniprotkb": "Iho1; Ccdc36", "gene_names_refseq": "Ccdc36; Iho1", "protein_names_uniprotkb": "Interactor of HORMAD1 protein 1; Coiled-coil domain-containing protein 36", "protein_names_refseq": "coiled-coil domain containing 36; coiled-coil domain-containing protein 36; interactor of HORMAD1 protein 1 isoform 1; interactor of HORMAD1 protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:434438)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;27723721;30569039;37431931", "class_list": "", "function": "Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation., [RefSeq, PubMed]; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:27723721). Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance (PubMed:27723721)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome", "go_biological_process": "GO:0060629 regulation of homologous chromosome segregation;GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PDM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70671-1", "uniprot_id": [ { "id": "IRF3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70671", "type": "external" } ], "mass": 46852.0, "length": 419, "protein_name": "Interferon regulatory factor 3", "gene_name": "Irf3", "organism": "Mouse", "refseq_name": "interferon regulatory factor 3", "refseq_ac": [ { "id": "NP_058545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058545", "type": "external" } ], "gene_names_uniprotkb": "Irf3", "gene_names_refseq": "C920001K05Rik; IRF-3; Irf3", "protein_names_uniprotkb": "Interferon regulatory factor 3; IRF-3", "protein_names_refseq": "interferon regulatory factor 3", "tax_id": 10090, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:54131); (R-MMU-1169408); (R-MMU-1606341); (R-MMU-168928); (R-MMU-3134973); (R-MMU-3134975); (R-MMU-3270619); (R-MMU-9013973); (R-MMU-918233); (R-MMU-933541); (R-MMU-936440); (R-MMU-936964)", "pathway_count": 12, "publication_count": 17, "publication_id_list": "11854279;11940575;12444163;12872135;15800576;16846591;16979567;18724932;18851954;20049431;21183079;21750661;22065572;30842237;34428180;35468896;39719712", "class_list": "", "function": "Activation of transcription factor IFN regulatory factor 3, the synthesis of large amounts of IFN-beta mRNA, and IFN-alpha/beta signal transduction in macrophages infected with Listeria monocytogenes, [RefSeq, PubMed]; Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex., [RefSeq, PubMed]; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:15800576, PubMed:39719712). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15800576, PubMed:39719712). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:16846591, PubMed:16979567, PubMed:20049431). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16846591, PubMed:16979567, PubMed:20049431). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591, PubMed:16979567, PubMed:20049431)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; May participate in the regulation of type I interferon transcription. May act as a modulator of isoform 1 function, decreasing its transcriptional activity during viral infection. Specifically binds to IFN-stimulated response elements (ISREs) in promoters of target genes, such as that of IFNB1., [UniProtKB, PubMed]; Role in regulating expression of ISG15-specific protease UBP43 in conjunction with lipopolysaccharide, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C0IXK2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P70671-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z307-1", "uniprot_id": [ { "id": "KCJ16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z307", "type": "external" } ], "mass": 48023.0, "length": 419, "protein_name": "Inward rectifier potassium channel 16", "gene_name": "Kcnj16", "organism": "Mouse", "refseq_name": "inward rectifier potassium channel 16", "refseq_ac": [ { "id": "NP_001239136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239136", "type": "external" } ], "gene_names_uniprotkb": "Kcnj16", "gene_names_refseq": "6430410F18Rik; Kcnj16; Kir5.1", "protein_names_uniprotkb": "Inward rectifier potassium channel 16; Inward rectifier K(+) channel Kir5.1; Potassium channel, inwardly rectifying subfamily J member 16", "protein_names_refseq": "inward rectifier K(+) channel Kir5.1; inward rectifier potassium channel 16; potassium channel, inwardly rectifying subfamily J member 16", "tax_id": 10090, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); EAST syndrome (Disease Ontology:DOID:0060484); hypokalemia (Disease Ontology:DOID:4500)", "pathway": " (mmu:16517); (R-MMU-1296041); (R-MMU-1296067); (R-MMU-997272)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15310750;21183079;21750661;33811157;34205849;37624905;9806850;9882736", "class_list": "", "function": "DNA N6-methyladenine methylase N6AMT1 controls neuropathic pain through epigenetically modifying Kcnj16 in dorsal horn neurons., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules., [UniProtKB, UniProtKB]; Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa. Publication Status: Online-Only, [RefSeq, PubMed]; Kir4.1/5.1 and Kir4.1 expression appeared to occur only in astrocytes, specifically in the membrane domains facing the pia mater and blood vessels or in the processes surrounding synapses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH37", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0034702 monoatomic ion channel complex;GO:0016020 membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane;GO:0006885 regulation of pH;GO:0010037 response to carbon dioxide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z307-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ATD1-1", "uniprot_id": [ { "id": "ISM1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ATD1", "type": "external" } ], "mass": 51145.0, "length": 454, "protein_name": "Isthmin-1", "gene_name": "Ism1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ism1; Ism", "gene_names_refseq": "", "protein_names_uniprotkb": "Isthmin-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:319909)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12128218;19874420;21750661", "class_list": "", "function": "Acts as an angiogenesis inhibitor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2ATD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UE31-1", "uniprot_id": [ { "id": "K0930_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UE31", "type": "external" } ], "mass": 45960.0, "length": 404, "protein_name": "Uncharacterized protein KIAA0930 homolog", "gene_name": "5031439G07Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA0930 homolog isoform 2", "refseq_ac": [ { "id": "NP_001028445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028445", "type": "external" } ], "gene_names_uniprotkb": "5031439G07Rik", "gene_names_refseq": "5031439G07Rik; mKIAA0930", "protein_names_uniprotkb": "Uncharacterized protein KIAA0930 homolog", "protein_names_refseq": "uncharacterized protein KIAA0930 homolog isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223739)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21183079;21750661;31219806;39927985", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCU3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UE31-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23611-1", "uniprot_id": [ { "id": "IRF8_MOUSE", "url": "https://www.uniprot.org/uniprot/P23611", "type": "external" } ], "mass": 48237.0, "length": 424, "protein_name": "Interferon regulatory factor 8", "gene_name": "Irf8", "organism": "Mouse", "refseq_name": "interferon regulatory factor 8", "refseq_ac": [ { "id": "NP_001288740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288740", "type": "external" } ], "gene_names_uniprotkb": "Irf8; Icsbp1; Icsbp", "gene_names_refseq": "ICSBP; IRF-8; Icsbp1; Irf8; Myls", "protein_names_uniprotkb": "Interferon regulatory factor 8; ICSBP; IRF-8; Interferon consensus sequence-binding protein", "protein_names_refseq": "interferon consensus sequence binding protein 1; interferon consensus sequence-binding protein; interferon regulatory factor 8", "tax_id": 10090, "disease": "familial chronic myelocytic leukemia-like syndrome (Disease Ontology:DOID:0060761); immunodeficiency 32B (Disease Ontology:DOID:0111985); immunodeficiency 32A (Disease Ontology:DOID:0111986); Behcet's disease (Disease Ontology:DOID:13241); systemic lupus erythematosus (Disease Ontology:DOID:9074); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:15900)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12393690;12461077;12538667;17579016;2111015;21750661;22992524;23382217;24528256;25428506;32741026;34428180", "class_list": "", "function": "The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]; Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:12393690, PubMed:2111015). Can both act as a transcriptional activator or repressor (PubMed:2111015). Plays a negative regulatory role in cells of the immune system (PubMed:2111015). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:12393690, PubMed:22992524). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (PubMed:12393690, PubMed:12461077, PubMed:12538667, PubMed:23382217). Positively regulates macroautophagy in dendritic cells (By similarity). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; We found that the transcriptional factor IRF8 plays a protective role in the cerebral ischaemic-reperfusion injury by attenuating neuronal apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0002273 plasmacytoid dendritic cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P23611-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SYL3-1", "uniprot_id": [ { "id": "BLTP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SYL3", "type": "external" } ], "mass": 254469.0, "length": 2234, "protein_name": "Bridge-like lipid transfer protein family member 2", "gene_name": "Bltp2", "organism": "Mouse", "refseq_name": "bridge-like lipid transfer protein family member 2 precursor", "refseq_ac": [ { "id": "NP_001002004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002004", "type": "external" } ], "gene_names_uniprotkb": "Bltp2; 2610507B11Rik; Kiaa0100", "gene_names_refseq": "2610507B11Rik; Bltp2; D11Bhm178e; D11Bhm179e; E1; mKIAA0100", "protein_names_uniprotkb": "Bridge-like lipid transfer protein family member 2; Protein KIAA0100", "protein_names_refseq": "bridge-like lipid transfer protein family member 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:72503)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25428506;34428180", "class_list": "", "function": "Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE65;Q66JY1;Q6DIC4;Q80U77;Q8C1W6;Q8CE06;Q8CGE3;Q9CSS8", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5SYL3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09036-1", "uniprot_id": [ { "id": "ISK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P09036", "type": "external" } ], "mass": 8488.0, "length": 80, "protein_name": "Serine protease inhibitor Kazal-type 1", "gene_name": "Spink1", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 1 precursor", "refseq_ac": [ { "id": "NP_033284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033284", "type": "external" } ], "gene_names_uniprotkb": "Spink1; Spink3", "gene_names_refseq": "Spink1; Spink3; p12", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 1; P12; Prostatic secretory glycoprotein; Serine protease inhibitor Kazal-type 3", "protein_names_refseq": "prostatic secretory glycoprotein; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1 precursor; serine protease inhibitor Kazal-type 1; serine protease inhibitor Kazal-type 3", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); ovary epithelial cancer (Disease Ontology:DOID:2152); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); cervical adenocarcinoma (Disease Ontology:DOID:3702); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:20730)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14645103;16083722;1929395;22228629;3428272;38763786;9828198", "class_list": "", "function": "Heterozygous Spink1 c.194+2T>C mutation promotes chronic pancreatitis after acute attack in mice., [RefSeq, PubMed]; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (PubMed:14645103, PubMed:16083722, PubMed:22228629, PubMed:9828198)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:14645103, PubMed:22228629, PubMed:3428272). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (PubMed:16083722)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9M3", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:0010466 negative regulation of peptidase activity;GO:0048240 sperm capacitation;GO:1900004 negative regulation of serine-type endopeptidase activity;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09036-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09450-1", "uniprot_id": [ { "id": "JUNB_MOUSE", "url": "https://www.uniprot.org/uniprot/P09450", "type": "external" } ], "mass": 35765.0, "length": 344, "protein_name": "Transcription factor JunB", "gene_name": "Junb", "organism": "Mouse", "refseq_name": "transcription factor JunB", "refseq_ac": [ { "id": "NP_032442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032442", "type": "external" } ], "gene_names_uniprotkb": "Junb; Jun-b", "gene_names_refseq": "Junb", "protein_names_uniprotkb": "Transcription factor JunB; MyD21; Transcription factor AP-1 subunit JunB", "protein_names_refseq": "Jun-B oncogene; jun B proto-oncogene; myD21; transcription factor AP-1 subunit JunB; transcription factor JunB; transcription factor jun-B", "tax_id": 10090, "disease": "anaplastic large cell lymphoma (Disease Ontology:DOID:0050744); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); gallbladder cancer (Disease Ontology:DOID:3121); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal carcinoma (Disease Ontology:DOID:4451); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); Hodgkin's lymphoma (Disease Ontology:DOID:8567); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:16477)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1690380;17242355;21183079;23806337;2498083;31219806;3422745;8530030;9889198", "class_list": "glycogene", "function": "Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (PubMed:2498083)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2G9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0033687 osteoblast proliferation;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P09450-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16382-1", "uniprot_id": [ { "id": "IL4RA_MOUSE", "url": "https://www.uniprot.org/uniprot/P16382", "type": "external" } ], "mass": 87627.0, "length": 810, "protein_name": "Interleukin-4 receptor subunit alpha", "gene_name": "Il4ra; Il4r", "organism": "Mouse", "refseq_name": "interleukin-4 receptor subunit alpha isoform 1 precursor", "refseq_ac": [ { "id": "NP_001008700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008700", "type": "external" } ], "gene_names_uniprotkb": "Il4ra; Il4r; Il4ra", "gene_names_refseq": "CD124; Il4ra; Il4r", "protein_names_uniprotkb": "Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP", "protein_names_refseq": "IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; interleukin-4 receptor subunit alpha isoform 1 precursor; interleukin-4 receptor subunit alpha", "tax_id": 10090, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); stroke (Disease Ontology:DOID:0051061); allergic conjunctivitis (Disease Ontology:DOID:11204); esophagitis (Disease Ontology:DOID:11963); pancreatic cancer (Disease Ontology:DOID:1793); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); acne (Disease Ontology:DOID:6543); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); multiple myeloma (Disease Ontology:DOID:9538); renal tuberculosis (Disease Ontology:DOID:9733)", "pathway": " (mmu:16190); (R-MMU-6785807)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;11465105;12242343;1534014;17675186;18250455;19144319;21750661;2405398;26124135;26495903;27802388;2805066;28935714;29255075;30779550;34428180;35984892;37828378;8390454;8757301;9348299", "class_list": "", "function": "Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O54690;Q60583;Q8CBW5", "ec_number_list": [], "go_molecular_function": "GO:0004913 interleukin-4 receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0043032 positive regulation of macrophage activation;GO:0032722 positive regulation of chemokine production;GO:0002532 production of molecular mediator involved in inflammatory response;GO:0035772 interleukin-13-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P16382-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61372-1", "uniprot_id": [ { "id": "ISL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61372", "type": "external" } ], "mass": 39036.0, "length": 349, "protein_name": "Insulin gene enhancer protein ISL-1", "gene_name": "Isl1", "organism": "Mouse", "refseq_name": "insulin gene enhancer protein ISL-1", "refseq_ac": [ { "id": "NP_067434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067434", "type": "external" } ], "gene_names_uniprotkb": "Isl1", "gene_names_refseq": "Isl1", "protein_names_uniprotkb": "Insulin gene enhancer protein ISL-1; Islet-1", "protein_names_refseq": "Islet 1; Lim-homeodomain protein Islet1; insulin gene enhancer protein ISL-1; insulin related protein; islet-1", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); myocardial infarction (Disease Ontology:DOID:5844); double outlet right ventricle (Disease Ontology:DOID:6406); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16392)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14664703;14667410;18539116;18583962;22343712;24643061;25775587;31219806;32928873;36112854", "class_list": "", "function": "DNA-binding transcriptional activator (PubMed:14664703, PubMed:18539116, PubMed:22343712, PubMed:24643061, PubMed:25775587). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes (PubMed:18539116, PubMed:24643061, PubMed:25775587). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:25775587). Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina (PubMed:24643061, PubMed:25775587). Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (PubMed:18583962). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (PubMed:14667410)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20663;P47894;Q812D8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0045880 positive regulation of smoothened signaling pathway;GO:0060384 innervation;GO:0021520 spinal cord motor neuron cell fate specification;GO:0021524 visceral motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61372-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03717-1", "uniprot_id": [ { "id": "KCNB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03717", "type": "external" } ], "mass": 95591.0, "length": 857, "protein_name": "Potassium voltage-gated channel subfamily B member 1", "gene_name": "Kcnb1", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily B member 1", "refseq_ac": [ { "id": "NP_032446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032446", "type": "external" } ], "gene_names_uniprotkb": "Kcnb1", "gene_names_refseq": "Kcnb1; Kcr1-1; Kv2.1; Shab", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1; mShab", "protein_names_refseq": "potassium voltage-gated channel subfamily B member 1; voltage-gated potassium channel subunit Kv2.1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 26 (Disease Ontology:DOID:0080461); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:16500); (R-MMU-1296072); (R-MMU-381676)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10414301;10506487;10921884;12270920;14684365;15858231;16452087;17114649;17767909;19357235;19383458;2002364;21183079;22056818;23161216;24477962;24494598;30084848;32848054;40885482", "class_list": "", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:14684365, PubMed:19383458, PubMed:24494598). Also plays a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:22056818). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (PubMed:22056818). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle (PubMed:10506487, PubMed:12270920, PubMed:17767909, PubMed:23161216, PubMed:24494598). Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation (By similarity). Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (PubMed:24494598). Contributes to the regulation of the glucose-induced amplitude and duration of action potentials in pancreatic beta-cells, hence limiting calcium influx and insulin secretion (PubMed:12270920, PubMed:17767909, PubMed:19383458, PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells (By similarity). May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval (PubMed:10506487, PubMed:14684365). Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury (By similarity). May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (By similarity). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0D1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0046982 protein heterodimerization activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010701 positive regulation of norepinephrine secretion;GO:0098900 regulation of action potential;GO:2000671 regulation of motor neuron apoptotic process;GO:0051260 protein homooligomerization;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q03717-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03719-1", "uniprot_id": [ { "id": "KCND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03719", "type": "external" } ], "mass": 71698.0, "length": 651, "protein_name": "A-type voltage-gated potassium channel KCND1", "gene_name": "Kcnd1", "organism": "Mouse", "refseq_name": "A-type voltage-gated potassium channel KCND1", "refseq_ac": [ { "id": "NP_032449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032449", "type": "external" } ], "gene_names_uniprotkb": "Kcnd1", "gene_names_refseq": "1110037K09Rik; Kca2-1; Kcnd1; Kv4.1; Shal1; Shal; mShal1", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND1; Potassium voltage-gated channel subfamily D member 1; Voltage-gated potassium channel subunit Kv4.1; mShal", "protein_names_refseq": "A-type voltage-gated potassium channel KCND1; potassium voltage-gated channel subfamily D member 1; voltage-gated potassium channel subunit Kv4.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16506); (R-MMU-1296072); (R-MMU-5576894)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11423117;19713751;2034678;21183079;28560311;32047055;33300544;33785038;34234278", "class_list": "", "function": "A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:28560311). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons (PubMed:28560311). Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials (PubMed:2034678). May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior (PubMed:28560311). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:28560311). The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (PubMed:11423117). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation., [RefSeq, PubMed]; Expression of the Kv4.1-targeted shRNA significantly decreased interspike intervals and increased repetitive firing rates in suprachiasmatic nucleus (SCN) neurons during the day and at night. results presented here also revealed that the acute knockdown of Kv4.1 had differential effects on the daytime and nighttime input resistance and repetitive firing rates in SCN neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation. Publication Status: Online-Only, [RefSeq, PubMed]; Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation., [RefSeq, PubMed]; This gene encodes a multipass transmembrane protein that comprises a subunit of voltage-gated rapidly inactivating A-type potassium channels. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC68", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005250 A-type (transient outward) potassium channel activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0045211 postsynaptic membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03719-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61410-1", "uniprot_id": [ { "id": "KGP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61410", "type": "external" } ], "mass": 87085.0, "length": 762, "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "Prkg2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prkg2; Prkgr2", "gene_names_refseq": "", "protein_names_uniprotkb": "cGMP-dependent protein kinase 2; 2.7.11.12; cGK 2; cGK2; cGKII; cGMP-dependent protein kinase II", "protein_names_refseq": "", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); acromesomelic dysplasia 4 (Disease Ontology:DOID:0081238); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); malignant renovascular hypertension (Disease Ontology:DOID:13730)", "pathway": " (R-MMU-1474151); (R-MMU-418457); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19282289;21183079;21750661;25428506;31219806;8514791;8953039", "class_list": "", "function": "Crucial regulator of intestinal secretion and bone growth (PubMed:8953039). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (PubMed:19282289)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.1.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.153", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "4.2.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.12", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051019 mitogen-activated protein kinase binding;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:2001226 negative regulation of chloride transport;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0072659 protein localization to plasma membrane;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61410-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZK5-1", "uniprot_id": [ { "id": "K1328_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZK5", "type": "external" } ], "mass": 69793.0, "length": 612, "protein_name": "Protein hinderin", "gene_name": "AW554918; Kiaa1328", "organism": "Mouse", "refseq_name": "protein hinderin isoform 1", "refseq_ac": [ { "id": "NP_001028704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028704", "type": "external" } ], "gene_names_uniprotkb": "AW554918; Kiaa1328", "gene_names_refseq": "4921538P22; AW554918; Kiaa1328; mKIAA1328", "protein_names_uniprotkb": "Protein hinderin", "protein_names_refseq": "protein hinderin isoform 1; protein hinderin", "tax_id": 10090, "disease": "", "pathway": " (mmu:225289)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;31219806;34428180", "class_list": "", "function": "Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJX2;Q571M8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NZK5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VV64-1", "uniprot_id": [ { "id": "KCNKI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VV64", "type": "external" } ], "mass": 44403.0, "length": 394, "protein_name": "Potassium channel subfamily K member 18", "gene_name": "Kcnk18", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 18", "refseq_ac": [ { "id": "NP_997144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997144", "type": "external" } ], "gene_names_uniprotkb": "Kcnk18; Tresk-2; Tresk2", "gene_names_refseq": "Gm781; Kcnk18; Tresk-2; Tresk; Trik", "protein_names_uniprotkb": "Potassium channel subfamily K member 18; Two-pore-domain potassium channel TRESK", "protein_names_refseq": "2P K ion channel TRESK; TWIK-related individual K+ channel; TWIK-related spinal cord K+ channel; potassium channel subfamily K member 18; two-pore-domain potassium channel TRESK", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); heart disease (Disease Ontology:DOID:114); epilepsy (Disease Ontology:DOID:1826); migraine (Disease Ontology:DOID:6364)", "pathway": " (mmu:332396); (R-MMU-1299344); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "14981085;15123670;16192517;16569637;17962323;18397886;18568022;20006580;20871611;25428506;30573346;32641496;33256222;33973102;34289346;34458705;34702947", "class_list": "", "function": "K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:14981085, PubMed:16192517, PubMed:16569637, PubMed:17962323). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (PubMed:17962323, PubMed:30573346, PubMed:32641496, PubMed:34458705). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (PubMed:34702947). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (PubMed:18568022)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage., [RefSeq, PubMed]; TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures., [RefSeq, PubMed]; TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells [TRESK-2], [RefSeq, PubMed]; The PQIVID sequence is a docking site for calcineurin, and its occupancy is required for the calcium-dependent regulation of TRESK, [RefSeq, PubMed]; Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZJ5;Q1LZM8;Q3MI50;Q3MI51", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0046872 metal ion binding;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0071467 cellular response to pH;GO:0071805 potassium ion transmembrane transport;GO:0097623 potassium ion export across plasma membrane;GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6VV64-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R071-1", "uniprot_id": [ { "id": "IP3KA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R071", "type": "external" } ], "mass": 50935.0, "length": 459, "protein_name": "Inositol-trisphosphate 3-kinase A", "gene_name": "Itpka", "organism": "Mouse", "refseq_name": "inositol-trisphosphate 3-kinase A", "refseq_ac": [ { "id": "NP_666237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666237", "type": "external" } ], "gene_names_uniprotkb": "Itpka", "gene_names_refseq": "Itpka", "protein_names_uniprotkb": "Inositol-trisphosphate 3-kinase A; 2.7.1.127; IP3 3-kinase A; IP3K A; Inositol 1,4,5-trisphosphate 3-kinase A; InsP 3-kinase A", "protein_names_refseq": "IP3 3-kinase A; IP3-kinase A; IP3K A; inositol-trisphosphate 3-kinase A; insP 3-kinase A", "tax_id": 10090, "disease": "", "pathway": " (mmu:228550); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17355905;19890013;20022963;21183079;22120525;24129315;27053114;29617377;34428180;36084651", "class_list": "", "function": "At synapses of Inositol-1,4,5-trisphosphate 3-kinase-A deficient neurons the levels of Ins(1,4,5)P3-5-phosphatase (inpp5a) and sarcoplasmic/endoplasmic reticulum calcium ATPase pump-2b (serca2b) were increased., [RefSeq, PubMed]; Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis., [UniProtKB, UniProtKB]; Findings demonstrate that IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala. Publication Status: Online-Only, [RefSeq, PubMed]; Inositol 1,4,5-trisphosphate 3-kinase A is critical for spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism., [RefSeq, PubMed]; Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities., [RefSeq, PubMed]; These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc], [RefSeq, PubMed]; Thisstudy shows that overexpressed IP3-kinase A plays a role in some forms of hippocampus-dependent learning and memory tasks as well as in synaptic transmission and plasticity by regulating both presynaptic and postsynaptic functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ20", "ec_number_list": [ { "id": "2.7.1.127", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.127", "type": "external" } ], "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0051592 response to calcium ion;GO:0048167 regulation of synaptic plasticity;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R071-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0A7-1", "uniprot_id": [ { "id": "K0513_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0A7", "type": "external" } ], "mass": 46318.0, "length": 407, "protein_name": "Uncharacterized protein KIAA0513", "gene_name": "6430548M08Rik; Kiaa0513", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA0513 isoform a", "refseq_ac": [ { "id": "NP_001157232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157232", "type": "external" } ], "gene_names_uniprotkb": "6430548M08Rik; Kiaa0513", "gene_names_refseq": "6430548M08Rik; Kiaa0513; mKIAA0513", "protein_names_uniprotkb": "Uncharacterized protein KIAA0513", "protein_names_refseq": "uncharacterized protein KIAA0513 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:234797)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;31219806;33300544;34203471;34428180;35820727;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TY8;Q8BQV3;Q8C8N9;Q8CCN0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R0A7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQF4-1", "uniprot_id": [ { "id": "JUNO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQF4", "type": "external" } ], "mass": 28203.0, "length": 244, "protein_name": "Sperm-egg fusion protein Juno", "gene_name": "Izumo1r", "organism": "Mouse", "refseq_name": "sperm-egg fusion protein Juno isoform 1 precursor", "refseq_ac": [ { "id": "NP_075026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075026", "type": "external" } ], "gene_names_uniprotkb": "Izumo1r; Folbp3; Folr4; Juno", "gene_names_refseq": "0910001L11Rik; Folbp3; Folr4; Izumo1r; Juno", "protein_names_uniprotkb": "Sperm-egg fusion protein Juno; FR-delta; Folate receptor 4; Folate receptor delta; Folate-binding protein 3; IZUMO1 receptor protein JUNO", "protein_names_refseq": "FR-delta; IZUMO1 receptor protein JUNO; folate receptor 4 (delta); folate-binding protein 3; probable folate receptor delta; sperm-egg fusion protein Juno isoform 1 precursor; sperm-egg fusion protein Juno", "tax_id": 10090, "disease": "", "pathway": " (mmu:64931); (R-MMU-163125)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11111049;17613255;19860584;21750661;22694797;24739963;25209248;26859261;27309808;27416963;36972453", "class_list": "", "function": "Novel splice variant of FR4 predominantly expressed in CD4+CD25+ regulatory T cells, [RefSeq, PubMed]; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:27416963). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:24739963, PubMed:26859261, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:24739963, PubMed:26859261, PubMed:27309808). Does not bind folate (PubMed:24739963)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Regulatory T cells (Treg) express high amounts of folate receptor 4, which distinguishes Treg from other naive or activated T cells., [RefSeq, PubMed]; This study describes a novel FR4 transcript variant, FR4D3, in which exon 3 is deleted. The mRNA of FR4D3 encodes a FR4 variant truncated by 189 bp. FR4D3 was found to be predominantly expressed in CD4(+)CD25(+) Treg cells. Publication Status: Online-Only, [RefSeq, PubMed]; Treg cells require Izumo1R to regulate gammadeltaT cell-driven inflammation in the skin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0FFS5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9EQF4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET78-1", "uniprot_id": [ { "id": "JPH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET78", "type": "external" } ], "mass": 74692.0, "length": 696, "protein_name": "Junctophilin-2", "gene_name": "Jph2", "organism": "Mouse", "refseq_name": "junctophilin-2", "refseq_ac": [ { "id": "NP_001192005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192005", "type": "external" } ], "gene_names_uniprotkb": "Jph2; Jp2", "gene_names_refseq": "1110002E14Rik; JP-2; Jp2; Jph2", "protein_names_uniprotkb": "Junctophilin-2; JP-2; Junctophilin type 2", "protein_names_refseq": "junctophilin type 2; junctophilin-2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy 2E (Disease Ontology:DOID:0081161); hypertrophic cardiomyopathy 17 (Disease Ontology:DOID:0110323); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:59091)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10949023;19095005;21183079;21339484;24129315;26063807;28393127;30409805;36288343;36706317;38438248;38960317;39317111;39927985", "class_list": "", "function": "Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies. Publication Status: Online-Only, [RefSeq, PubMed]; Junctophilin-2 is a double-stranded RNA-binding protein that regulates cardiomyocyte-autonomous innate immune response., [RefSeq, PubMed]; Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:10949023, PubMed:19095005, PubMed:21339484). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (PubMed:10949023, PubMed:19095005, PubMed:21339484). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (PubMed:10949023, PubMed:19095005, PubMed:21339484). Contributes to the construction of skeletal muscle triad junctions (PubMed:10949023)., [UniProtKB, PubMed, PubMed, PubMed]; Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity., [RefSeq, PubMed]; Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction., [RefSeq, PubMed]; Transcription repressor required to safeguard against the deleterious effects of cardiac stress (PubMed:30409805). Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes (PubMed:30409805). Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis (PubMed:30409805). Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress (PubMed:30409805). Probably acts by competing with MEF2 transcription factors and TATA-binding proteins (PubMed:30409805)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U077;Q9ET79", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0003677 DNA binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030018 Z disc", "go_biological_process": "GO:0055024 regulation of cardiac muscle tissue development;GO:0006351 DNA-templated transcription;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9ET78-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2K1-1", "uniprot_id": [ { "id": "K1C16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2K1", "type": "external" } ], "mass": 51606.0, "length": 469, "protein_name": "Keratin, type I cytoskeletal 16", "gene_name": "Krt16", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 16 isoform 1", "refseq_ac": [ { "id": "NP_001300887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300887", "type": "external" } ], "gene_names_uniprotkb": "Krt16; Krt1-16", "gene_names_refseq": "CK-16; K16; Krt1-16; Krt16", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 16; CK-16; Cytokeratin-16; K16; Keratin-16", "protein_names_refseq": "cytokeratin-16; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin, type I cytoskeletal 16 isoform 1; keratin, type I cytoskeletal 16", "tax_id": 10090, "disease": "nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0050428); pachyonychia congenita (Disease Ontology:DOID:0050449); focal nonepidermolytic palmoplantar keratoderma 1 (Disease Ontology:DOID:0111709); ectodermal dysplasia (Disease Ontology:DOID:2121)", "pathway": " (mmu:16666); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11029038;11408584;12445204;16702408;22336941;24218583;25428506;26758872;34428180;34887587;35820727;36210013;36583994;37828378;39627609;8636216;9822705", "class_list": "", "function": "Epidermis-specific type I keratin that plays a key role in skin (PubMed:22336941, PubMed:24218583). Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance (PubMed:24218583)., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005882 intermediate filament;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0051546 keratinocyte migration;GO:0006954 inflammatory response;GO:0031424 keratinization;GO:0045087 innate immune response;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z2K1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16388-1", "uniprot_id": [ { "id": "KCNA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P16388", "type": "external" } ], "mass": 56409.0, "length": 495, "protein_name": "Potassium voltage-gated channel subfamily A member 1", "gene_name": "Kcna1", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 1", "refseq_ac": [ { "id": "NP_034725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034725", "type": "external" } ], "gene_names_uniprotkb": "Kcna1", "gene_names_refseq": "Kca1-1; Kcna1; Kv1.1; MBK1; Mk-1; Shak; mceph", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 1; MBK1; MKI; Voltage-gated potassium channel subunit Kv1.1", "protein_names_refseq": "MKI; brain potassium channel protein-1; megencephaly; potassium voltage-gated channel subfamily A member 1; voltage-gated potassium channel subunit Kv1.1", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (mmu:16485); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10191303;12611922;12907802;14686897;15361858;16452087;17250763;17315199;17917103;19307729;20392939;21233214;21483673;21966978;22158511;22396426;22411008;22641786;2305265;23466697;23473320;23903368;2451788;25377007;26269648;33300544;36417872;7517498;8046438;8126562;8361541;8995755;9581771;9736643", "class_list": "", "function": "Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:10191303, PubMed:12611922, PubMed:21966978, PubMed:22158511, PubMed:23473320, PubMed:9581771, PubMed:9736643). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15361858). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:15361858). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:15361858, PubMed:7517498). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability (PubMed:23466697). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (PubMed:20392939, PubMed:22641786, PubMed:25377007). Required for normal neuromuscular responses (PubMed:9736643). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (PubMed:23473320). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (PubMed:21966978, PubMed:22396426). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (PubMed:21233214). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (PubMed:17250763, PubMed:17315199, PubMed:22411008, PubMed:8995755). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0097718 disordered domain specific binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034705 potassium channel complex;GO:0044305 calyx of Held;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0001964 startle response;GO:0086011 membrane repolarization during action potential;GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0023041 neuronal signal transduction;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P16388-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61923-1", "uniprot_id": [ { "id": "KCNA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61923", "type": "external" } ], "mass": 58674.0, "length": 529, "protein_name": "Potassium voltage-gated channel subfamily A member 6", "gene_name": "Kcna6", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 6", "refseq_ac": [ { "id": "NP_038596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038596", "type": "external" } ], "gene_names_uniprotkb": "Kcna6", "gene_names_refseq": "Kcna6; Kv1.6; MK1.6", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 6; MK1.6; Voltage-gated potassium channel subunit Kv1.6", "protein_names_refseq": "potassium voltage-gated channel subfamily A member 6; voltage-gated potassium channel subunit Kv1.6", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:16494); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1285906;21183079;29139549;38043654", "class_list": "", "function": "Proteome landscape and interactome of voltage-gated potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (By similarity). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61923-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0V1-1", "uniprot_id": [ { "id": "KCND3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0V1", "type": "external" } ], "mass": 73462.0, "length": 655, "protein_name": "A-type voltage-gated potassium channel KCND3", "gene_name": "Kcnd3", "organism": "Mouse", "refseq_name": "A-type voltage-gated potassium channel KCND3 isoform 1", "refseq_ac": [ { "id": "NP_001034436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034436", "type": "external" } ], "gene_names_uniprotkb": "Kcnd3", "gene_names_refseq": "Kcnd3; Kncd3; Kv4.3", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3", "protein_names_refseq": "A-type voltage-gated potassium channel KCND3 isoform 1; A-type voltage-gated potassium channel KCND3; potassium channel Kv4.3L; potassium channel Kv4.3M; potassium voltage-gated channel subfamily D member 3; voltage-gated potassium channel subunit Kv4.3", "tax_id": 10090, "disease": "spinocerebellar ataxia 19/22 (Disease Ontology:DOID:0050970); Brugada syndrome 9 (Disease Ontology:DOID:0110226)", "pathway": " (mmu:56543); (R-MMU-1296072); (R-MMU-5576894)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11598014;11909823;19713751;21183079;25428506;30084848;34428180", "class_list": "", "function": "Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (By similarity). In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC44;Q9Z0V0", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0005216 monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0099625 ventricular cardiac muscle cell membrane repolarization;GO:0006936 muscle contraction;GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0V1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52480-1", "uniprot_id": [ { "id": "KPYM_MOUSE", "url": "https://www.uniprot.org/uniprot/P52480", "type": "external" } ], "mass": 57845.0, "length": 531, "protein_name": "Pyruvate kinase PKM", "gene_name": "Pkm", "organism": "Mouse", "refseq_name": "pyruvate kinase PKM isoform M1", "refseq_ac": [ { "id": "NP_001240812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240812", "type": "external" } ], "gene_names_uniprotkb": "Pkm; Pk3; Pkm2; Pykm", "gene_names_refseq": "Pk-2; Pk-3; Pk3; Pkm2; Pkm", "protein_names_uniprotkb": "Pyruvate kinase PKM; 2.7.1.40; 2.7.10.2; 2.7.11.1; Pyruvate kinase muscle isozyme; Threonine-protein kinase PKM2; Tyrosine-protein kinase PKM2", "protein_names_refseq": "pyruvate kinase 3; pyruvate kinase PKM isoform M1; pyruvate kinase PKM; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; threonine-protein kinase PKM2; tyrosine-protein kinase PKM2", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:18746); (R-MMU-6798695); (R-MMU-70171); (R-MMU-70268); (R-MMU-9861718)", "pathway_count": 5, "publication_count": 49, "publication_id_list": "16139798;18034455;18191611;21540332;21750661;22645316;22872234;23386199;23806337;24142698;24788674;25428506;25605945;26495903;26992222;27384996;27802388;28011936;28528544;28575669;29259242;29996098;30084848;30487609;31219806;31554233;31599954;32152506;32863213;32938830;33300544;33725478;33984439;34428180;34678516;34887587;35790734;35820727;35984892;36064721;36288343;37453647;37507081;37828378;39627609;39927985;40684658;7612666;9545585", "class_list": "", "function": "Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (By similarity). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (By similarity). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (By similarity). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (By similarity). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (PubMed:29996098). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (PubMed:28575669). Plays a role in caspase independent cell death of tumor cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBV8;Q3TBW5;Q3TC59;Q3U1X3;Q3U5P6;Q4VC20;Q64484;Q91YI8;Q9CWB1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0035402 histone H3T11 kinase activity;GO:0000287 magnesium ion binding;GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:1902912 pyruvate kinase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:1903672 positive regulation of sprouting angiogenesis;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P52480-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQ88-1", "uniprot_id": [ { "id": "KDM1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQ88", "type": "external" } ], "mass": 92851.0, "length": 853, "protein_name": "Lysine-specific histone demethylase 1A", "gene_name": "Kdm1a", "organism": "Mouse", "refseq_name": "lysine-specific histone demethylase 1A isoform 1", "refseq_ac": [ { "id": "NP_001334150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334150", "type": "external" } ], "gene_names_uniprotkb": "Kdm1a; Aof2; Kiaa0601; Lsd1", "gene_names_refseq": "1810043O07Rik; Aof2; D4Ertd478e; Kdm1a; Kdm1; Lsd1; mKIAA0601", "protein_names_uniprotkb": "Lysine-specific histone demethylase 1A; 1.14.11.-; 1.14.11.65; 1.14.99.66; BRAF35-HDAC complex protein BHC110; Flavin-containingso amine oxidase domain-containing protein 2", "protein_names_refseq": "BRAF35-HDAC complex protein BHC110; amine oxidase (flavin containing) domain 2; flavin-containing amine oxidase domain-containing protein 2; flavin-containingso amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1; lysine-specific histone demethylase 1A isoform 1; lysine-specific histone demethylase 1A", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:99982); (R-MMU-3214815); (R-MMU-3214842); (R-MMU-9018519); (R-MMU-9764725); (R-MMU-983231)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "16079795;17707228;19098913;19144319;20164337;20713442;21183079;21750661;24227653;25018020;26206133;26214369;26976584;27572339;28687800;31219806;34428180", "class_list": "", "function": "Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:19098913). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1 (By similarity). Demethylates methylated 'Lys-44' and methylated 'Lys-119' of SOX2 (By similarity). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Required for the repression of GIPR expression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; LSD1 interacts with androgen receptor in vitro and in vivo, and stimulates androgen-receptor-dependent transcription [LSD1], [RefSeq, PubMed]; Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark (By similarity). This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory (PubMed:26214369). Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A3KG93;A3KG94;F6Z4I3;Q6PB53;Q8VEA1", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0061752 telomeric repeat-containing RNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:2000648 positive regulation of stem cell proliferation;GO:0046098 guanine metabolic process;GO:0010725 regulation of primitive erythrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6ZQ88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1Y2-1", "uniprot_id": [ { "id": "KPCD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1Y2", "type": "external" } ], "mass": 100078.0, "length": 889, "protein_name": "Serine/threonine-protein kinase D3", "gene_name": "Prkd3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase D3 isoform 2", "refseq_ac": [ { "id": "NP_083515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083515", "type": "external" } ], "gene_names_uniprotkb": "Prkd3; Prkcn", "gene_names_refseq": "4930557O20Rik; 5730497N19Rik; PKD3; Pkcnu; Prkcn; Prkd3", "protein_names_uniprotkb": "Serine/threonine-protein kinase D3; 2.7.11.13; Protein kinase C nu type; nPKC-nu", "protein_names_refseq": "nPKC-nu; protein kinase C nu type; protein kinase C, nu; serine/threonine-protein kinase D3 isoform 2; serine/threonine-protein kinase D3", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:75292)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12506120;16380377;17242355;18439271;21183079;21750661;25428506;30084848;34428180;36318273;36466811;37044359", "class_list": "", "function": "Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity)., [UniProtKB]; PKCnu is an important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement, [RefSeq, PubMed]; PKD3 is increasingly expressed in neuronal as well as in the supporting connective tissue and in skeletal muscles Publication Status: Online-Only, [RefSeq, PubMed]; Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice., [RefSeq, PubMed]; Protein kinase D3 promotes neutrophil migration during viral infection., [RefSeq, PubMed]; T cell-intrinsic protein kinase D3 is dispensable for the cells' activation. Publication Status: Online-Only, [RefSeq, PubMed]; The catalytic activity of PKD3 may regulate its nuclear import through autophosphorylation and/or interaction with another protein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0036064 ciliary basal body;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0023056 positive regulation of signaling;GO:0010647 positive regulation of cell communication", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K1Y2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KR2-1", "uniprot_id": [ { "id": "LRIG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q52KR2", "type": "external" } ], "mass": 117863.0, "length": 1054, "protein_name": "Leucine-rich repeats and immunoglobulin-like domains protein 2", "gene_name": "Lrig2", "organism": "Mouse", "refseq_name": "leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001020238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020238", "type": "external" } ], "gene_names_uniprotkb": "Lrig2; Kiaa0806", "gene_names_refseq": "4632419I10Rik; LIG-2; Lrig2", "protein_names_uniprotkb": "Leucine-rich repeats and immunoglobulin-like domains protein 2; LIG-2", "protein_names_refseq": "leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor; leucine-rich repeats and immunoglobulin-like domains protein 2", "tax_id": 10090, "disease": "urofacial syndrome (Disease Ontology:DOID:0050816)", "pathway": " (mmu:269473)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15592455;21750661;24023893;25428506;26651291;30084848;30779550;30885509;34428180;36183058;36210013", "class_list": "", "function": "LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma. Publication Status: Online-Only, [RefSeq, PubMed]; Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease, [RefSeq, PubMed]; Mice with homozygous mutations in either Lrig2 or Hpse2 had increased nerve density within the urinary bladder body and decreased nerve density around the urinary outflow tract. Observations provide evidence that a peripheral neuropathy is central to the pathobiology of functional bladder outlet obstruction in urofacial syndrome and emphasize the importance of LRIG2 and Hpse2 for nerve patterning in the urinary tract., [RefSeq, PubMed]; Phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZY8", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0060384 innervation;GO:0048679 regulation of axon regeneration;GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway;GO:2000010 positive regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q52KR2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1T0-1", "uniprot_id": [ { "id": "LIGO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1T0", "type": "external" } ], "mass": 69101.0, "length": 614, "protein_name": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1", "gene_name": "Lingo1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001298005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298005", "type": "external" } ], "gene_names_uniprotkb": "Lingo1; Lern1; Lrrn6a", "gene_names_refseq": "4930471K13Rik; LERN1; LINGO-1; Lingo1; Lrrn6a; UNQ201", "protein_names_uniprotkb": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A", "protein_names_refseq": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 1 precursor; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine-rich repeat neuronal protein 1; leucine-rich repeat neuronal protein 6A", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 64 (Disease Ontology:DOID:0081225); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:235402); (R-MMU-193634)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;14686891;17114649;17726113;18186492;20093372;21183079;22923615;30899004;31132364;33300544;33830473;34187584;38142924", "class_list": "", "function": "Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice., [RefSeq, PubMed]; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development., [UniProtKB, PubMed, UniProtKB, PubMed]; Inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration, [RefSeq, PubMed]; LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels. Publication Status: Online-Only, [RefSeq, PubMed]; LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-kappaB and JAK2/STAT3., [RefSeq, PubMed]; Results suggested that LINGO-1 plays a critical role in the injury microenvironment in processes such as cell death, inflammatory response, and glial scar formation after spinal cord injury, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQJ4;Q6VVF9;Q7TT38", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0031175 neuron projection development;GO:0048666 neuron development;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0021954 central nervous system neuron development;GO:0048715 negative regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9D1T0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2F8-1", "uniprot_id": [ { "id": "LS14A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2F8", "type": "external" } ], "mass": 50546.0, "length": 462, "protein_name": "Protein LSM14 homolog A", "gene_name": "Lsm14a", "organism": "Mouse", "refseq_name": "protein LSM14 homolog A isoform 1", "refseq_ac": [ { "id": "NP_080224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080224", "type": "external" } ], "gene_names_uniprotkb": "Lsm14a; Fam61a; Rap55a", "gene_names_refseq": "2700023B17Rik; Lsm14a; Tral; mRAP55A", "protein_names_uniprotkb": "Protein LSM14 homolog A; Protein FAM61A; RNA-associated protein 55A; mRAP55A", "protein_names_refseq": "RNA-associated protein 55A; protein LSM14 homolog A isoform 1; protein LSM14 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67070)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18723115;19131326;19144319;21183079;21750661;24129315;27183626;34428180;34887587;40885482", "class_list": "", "function": "Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly., [UniProtKB, UniProtKB]; Results suggest that LSm14A plays an important role in antiviral innate and adaptive immune responses by modulating MITA level in a cell type-specific manner, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTG8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003690 double-stranded DNA binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0051607 defense response to virus;GO:0090307 mitotic spindle assembly;GO:0017148 negative regulation of translation;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K2F8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97311-1", "uniprot_id": [ { "id": "MCM6_MOUSE", "url": "https://www.uniprot.org/uniprot/P97311", "type": "external" } ], "mass": 92867.0, "length": 821, "protein_name": "DNA replication licensing factor MCM6", "gene_name": "Mcm6", "organism": "Mouse", "refseq_name": "DNA replication licensing factor MCM6 isoform 1", "refseq_ac": [ { "id": "NP_032593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032593", "type": "external" } ], "gene_names_uniprotkb": "Mcm6; Mcmd6; Mis5", "gene_names_refseq": "ASP-l1; D1Wsu22e; Mcm6; Mcmd6", "protein_names_uniprotkb": "DNA replication licensing factor MCM6; 3.6.4.12; Mis5 homolog", "protein_names_refseq": "DNA replication licensing factor MCM6 isoform 1; DNA replication licensing factor MCM6; mini chromosome maintenance deficient 6; minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)", "tax_id": 10090, "disease": "", "pathway": " (mmu:17219); (R-MMU-176187); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10567526;17525332;21183079;22872234;23806337;25428506;25605945;30084848;31219806;34203471;34428180;35820727;37454373;39627609;9077461", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, PubMed]; UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YQ7", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:1902969 mitotic DNA replication;GO:0006279 premeiotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P97311-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU41-1", "uniprot_id": [ { "id": "LRC8B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU41", "type": "external" } ], "mass": 92186.0, "length": 803, "protein_name": "Volume-regulated anion channel subunit LRRC8B", "gene_name": "Lrrc8b", "organism": "Mouse", "refseq_name": "volume-regulated anion channel subunit LRRC8B", "refseq_ac": [ { "id": "NP_001028722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028722", "type": "external" } ], "gene_names_uniprotkb": "Lrrc8b; Kiaa0231", "gene_names_refseq": "2210408K08Rik; Lrrc8b; Ta-lrrp; mKIAA0231", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8B; Leucine-rich repeat-containing protein 8B", "protein_names_refseq": "T-cell activation leucine repeat-rich protein; leucine-rich repeat-containing protein 8B; volume-regulated anion channel subunit LRRC8B", "tax_id": 10090, "disease": "", "pathway": " (mmu:433926); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;21952136;24782309;25428506;30084848;33300544;34418053;34428180;36522427", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:36522427)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RSI6", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0015810 aspartate transmembrane transport;GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5DU41-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WG5-1", "uniprot_id": [ { "id": "LRC8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WG5", "type": "external" } ], "mass": 94120.0, "length": 810, "protein_name": "Volume-regulated anion channel subunit LRRC8A", "gene_name": "Lrrc8a", "organism": "Mouse", "refseq_name": "volume-regulated anion channel subunit LRRC8A", "refseq_ac": [ { "id": "NP_808393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808393", "type": "external" } ], "gene_names_uniprotkb": "Lrrc8a; Lrrc8; Swell1", "gene_names_refseq": "Lrrc8a; Lrrc8; SWELL1; ebo; mKIAA1437", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8A; Leucine-rich repeat-containing protein 8A; Protein ebouriffe; Swelling protein 1; ebo", "protein_names_refseq": "leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; protein ebouriffe; swelling protein 1; volume-regulated anion channel subunit LRRC8A", "tax_id": 10090, "disease": "agammaglobulinemia 5 (Disease Ontology:DOID:0080588); agammaglobulinemia (Disease Ontology:DOID:2583)", "pathway": " (mmu:241296); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;14660746;15094057;21183079;24725410;24752297;24782309;25428506;28192143;29371604;29769723;29773801;29880644;30135305;30779550;31387946;32277911;32930093;33300544;35820727;36522427;36928458;37828378;38006980;38847616;8828840", "class_list": "", "function": "ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity., [RefSeq, PubMed]; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723, PubMed:30135305, PubMed:36522427, PubMed:36928458). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:32277911). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (By similarity). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:36522427, PubMed:36928458). Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (PubMed:31387946, PubMed:32930093). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604, PubMed:29773801). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). Acts as a key factor in NLRP3 inflammasome activation by modulating itaconate efflux and mitochondria function (PubMed:38006980)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AQZ0", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity;GO:0042802 identical protein binding;GO:0140360 cyclic-GMP-AMP transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0006970 response to osmotic stress;GO:0007283 spermatogenesis;GO:0032024 positive regulation of insulin secretion;GO:0006884 cell volume homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q80WG5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149C2-1", "uniprot_id": [ { "id": "MIPT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149C2", "type": "external" } ], "mass": 71037.0, "length": 625, "protein_name": "TRAF3-interacting protein 1", "gene_name": "Traf3ip1", "organism": "Mouse", "refseq_name": "TRAF3-interacting protein 1", "refseq_ac": [ { "id": "NP_082994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082994", "type": "external" } ], "gene_names_uniprotkb": "Traf3ip1; Ift54; Mipt3", "gene_names_refseq": "3930402D05Rik; MIP-T3; Traf3ip1", "protein_names_uniprotkb": "TRAF3-interacting protein 1; Intraflagellar transport protein 54 homolog; MIP-T3; Microtubule-interacting protein associated with TRAF3", "protein_names_refseq": "TNF receptor-associated factor 3 interacting protein 1; TRAF3-interacting protein 1; intraflagellar transport protein 54 homolog; microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3", "tax_id": 10090, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (mmu:74019); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19253336;21183079;21750661;21945076;26487268;31219806;34428180", "class_list": "", "function": "Data show that overexpression of IFT54/Traf3ip1 displaces IFT20 from the Golgi apparatus. IFT54s effect on IFT20 is a dominant negative phenotype caused by its overexpression., [RefSeq, PubMed]; Homozygous Traf3ip1 mutants are not viable and have both neural developmental defects and polydactyly, phenotypes typical of mutants with ciliary assembly defects., [RefSeq, PubMed]; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in epithelial morphogenesis and in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (PubMed:21945076)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q538H5;Q80VQ3;Q9CS98", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001822 kidney development;GO:0001933 negative regulation of protein phosphorylation;GO:0031076 embryonic camera-type eye development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q149C2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35678-1", "uniprot_id": [ { "id": "MGLL_MOUSE", "url": "https://www.uniprot.org/uniprot/O35678", "type": "external" } ], "mass": 33388.0, "length": 303, "protein_name": "Monoglyceride lipase", "gene_name": "Mgll", "organism": "Mouse", "refseq_name": "monoglyceride lipase isoform c", "refseq_ac": [ { "id": "NP_001159721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159721", "type": "external" } ], "gene_names_uniprotkb": "Mgll", "gene_names_refseq": "Magl; Mgll; Mgl", "protein_names_uniprotkb": "Monoglyceride lipase; 3.1.1.23; MAGL; MGL; Monoacylglycerol lipase", "protein_names_refseq": "monoacylglycerol lipase; monoglyceride lipase isoform c", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:23945); (R-MMU-1482883); (R-MMU-426048)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11470505;15371507;16800626;17700715;18096503;19029917;20554061;20729846;21183079;21454566;21750661;34428180;35820727;37507081;9341166", "class_list": "", "function": "Astrocytes express monoacylglycerol lipase, the main hydrolyzing enzyme of 2-arachidonoylglycerol. Pharmacological inhibition of MGL potentiates ATP-induced 2-AG production., [RefSeq, PubMed]; Converts monoacylglycerides to free fatty acids and glycerol (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2R0;Q9D9G8", "ec_number_list": [ { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0006633 fatty acid biosynthetic process;GO:0046464 acylglycerol catabolic process;GO:0051930 regulation of sensory perception of pain;GO:0060292 long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35678-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UIK4-1", "uniprot_id": [ { "id": "MET14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UIK4", "type": "external" } ], "mass": 52122.0, "length": 456, "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "Mettl14", "organism": "Mouse", "refseq_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "refseq_ac": [ { "id": "NP_964000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_964000", "type": "external" } ], "gene_names_uniprotkb": "Mettl14; Kiaa1627", "gene_names_refseq": "G430022H21Rik; Mettl14; mKIAA1627", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; Methyltransferase-like protein 14", "protein_names_refseq": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14; methyltransferase like 14; methyltransferase-like protein 14; snoRNA MBII-84", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (mmu:210529); (R-MMU-72203)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "21750661;22872234;24394384;28914256;28965759;29535189;29547716;30084848;30779550;31219806;34203471;34428180;35820727", "class_list": "", "function": "The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPL2;Q80UR9", "ec_number_list": [], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003729 mRNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0140640 catalytic activity, acting on a nucleic acid", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021861 forebrain radial glial cell differentiation;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0007283 spermatogenesis;GO:0016556 mRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3UIK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YQ2-1", "uniprot_id": [ { "id": "MED23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YQ2", "type": "external" } ], "mass": 156087.0, "length": 1367, "protein_name": "Mediator of RNA polymerase II transcription subunit 23", "gene_name": "Med23", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 23 isoform 1", "refseq_ac": [ { "id": "NP_001159888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159888", "type": "external" } ], "gene_names_uniprotkb": "Med23; Crsp3; Kiaa1216; Sur2", "gene_names_refseq": "130kDa; 3000002A17Rik; Crsp3; ESTM7; Med23; Sur2; mKIAA1216; snouty; sno", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 23; CRSP complex subunit 3; Cofactor required for Sp1 transcriptional activation subunit 3; Mediator complex subunit 23; Protein sur-2 homolog; mSur-2", "protein_names_refseq": "CRSP complex subunit 3; cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3 (130kD); mSur-2; mediator of RNA polymerase II transcription subunit 23 isoform 1; mediator of RNA polymerase II transcription subunit 23; protein sur-2 homolog", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 18 (Disease Ontology:DOID:0081190)", "pathway": " (mmu:70208)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11934987;14759369;15542641;15749018;16137621;20111005;20173027;21750661;25428506;28011936;30084848;30779550;31219806;34428180;36210013;38691453", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPV7;Q8CEC3;Q8K587;Q9CXY8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80YQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R516-1", "uniprot_id": [ { "id": "MIB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R516", "type": "external" } ], "mass": 105961.0, "length": 973, "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "Mib2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MIB2 isoform 2", "refseq_ac": [ { "id": "NP_001243037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243037", "type": "external" } ], "gene_names_uniprotkb": "Mib2; Skd", "gene_names_refseq": "2210008I11Rik; Mib2; Zzank1; skd", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MIB2; 2.3.2.27; Dyslike; Dystrophin-like protein; Mind bomb homolog 2; Mind bomb-2; RING-type E3 ubiquitin transferase MIB2; Skeletrophin", "protein_names_refseq": "E3 ubiquitin-protein ligase MIB2 isoform 2; E3 ubiquitin-protein ligase MIB2; RING-type E3 ubiquitin transferase MIB2; dyslike; dystrophin-like protein; mind bomb-2; mindbomb homolog 2; skeletrophin; zinc finger, ZZ type with ankyrin repeat domain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76580); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-983168); (R-MMU-9931295)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "15824097;17987667;20485683;21750661;30084848;31219806;36719382;39019259", "class_list": "", "function": "Created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors., [UniProtKB, PubMed]; MIB2 Functions in Oocyte Meiosis by Modulating Chromatin Configuration., [RefSeq, PubMed]; Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase, [RefSeq, PubMed]; PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A9P9;Q52QU8;Q6PEF6;Q8C1N7;Q8VIB4", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization;GO:0140252 regulation protein catabolic process at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R516-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62425-1", "uniprot_id": [ { "id": "CXFA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62425", "type": "external" } ], "mass": 9327.0, "length": 82, "protein_name": "Cytochrome c oxidase subunit FA4", "gene_name": "Coxfa4", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit FA4", "refseq_ac": [ { "id": "NP_035016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035016", "type": "external" } ], "gene_names_uniprotkb": "Coxfa4; Ndufa4", "gene_names_refseq": "Coxfa4; MLRQ; Ndufa4", "protein_names_uniprotkb": "Cytochrome c oxidase subunit FA4; Cytochrome c oxidase subunit NDUFA4", "protein_names_refseq": "Ndufa4, mitochondrial complex associated; cytochrome c oxidase subunit FA4; cytochrome c oxidase subunit NDUFA4", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 21 (Disease Ontology:DOID:0070506)", "pathway": " (mmu:17992); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 47, "publication_id_list": "10755612;11581311;11719190;11994422;12469116;15240697;16452087;17670943;18250455;18299400;19224205;20173027;20484733;21183079;21750661;21913724;21952136;22233579;22872234;22902835;23576753;25428506;25428507;25605945;26495903;27802388;28011936;30084848;30779550;32973183;33300544;33649389;34428180;35820727;35984892;36288343;37211637;37453647;37507081;37602474;37828378;39627609;39927985;9064319;9391114;9469799;9551915", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. COXFA4 is required for complex IV maintenance., [UniProtKB, UniProtKB]; MiR-147 Represses NDUFA4, Inducing Mitochondrial Dysfunction and Tubular Damage in Cold Storage Kidney Transplantation., [RefSeq, PubMed]; NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQP6", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q62425-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UIU2-1", "uniprot_id": [ { "id": "NDUB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UIU2", "type": "external" } ], "mass": 15515.0, "length": 128, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6", "gene_name": "Ndufb6", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6", "refseq_ac": [ { "id": "NP_001028477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028477", "type": "external" } ], "gene_names_uniprotkb": "Ndufb6; Gm137", "gene_names_refseq": "CI-B17; Gm137; Ndufb6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; CI-B17; Complex I-B17; NADH-ubiquinone oxidoreductase B17 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; NADH-ubiquinone oxidoreductase B17 subunit; complex I-B17", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:230075); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;23576753;34428180;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This gene encodes a subunit of complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain. This complex functions in electron transport and generation of a proton gradient across the inner mitochondrial membrane to drive ATP synthesis. Data from human cell lines suggests that the encoded subunit may be required for electron transfer activity. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UIU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNJ6-1", "uniprot_id": [ { "id": "NETO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNJ6", "type": "external" } ], "mass": 59368.0, "length": 525, "protein_name": "Neuropilin and tolloid-like protein 2", "gene_name": "Neto2", "organism": "Mouse", "refseq_name": "neuropilin and tolloid-like protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001074793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074793", "type": "external" } ], "gene_names_uniprotkb": "Neto2; Btcl2", "gene_names_refseq": "5530601C23Rik; BTCL2; Neto2", "protein_names_uniprotkb": "Neuropilin and tolloid-like protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2", "protein_names_refseq": "brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; neuropilin and tolloid-like protein 2 isoform 3; neuropilin and tolloid-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74513)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15464227;19217376;21183079;32788298;33390848", "class_list": "", "function": "Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity)., [UniProtKB]; Btcl2 mRNA was observed restrictively in brain throughout embryonic and postnatal stages; expressed in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation., [RefSeq, PubMed]; Kainate Receptor Auxiliary Subunit NETO2-Related Cued Fear Conditioning Impairments Associate with Defects in Amygdala Development and Excitability. Publication Status: Online-Only, [RefSeq, PubMed]; NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RX93;Q5VM49;Q8C4Q8", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BNJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQZ6-1", "uniprot_id": [ { "id": "NDUB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQZ6", "type": "external" } ], "mass": 11692.0, "length": 104, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3", "gene_name": "Ndufb3", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3", "refseq_ac": [ { "id": "NP_079873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079873", "type": "external" } ], "gene_names_uniprotkb": "Ndufb3", "gene_names_refseq": "2700033I16Rik; CI-B12; Ndufb3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; CI-B12; Complex I-B12; NADH-ubiquinone oxidoreductase B12 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; NADH-ubiquinone oxidoreductase B12 subunit; complex I-B12", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 25 (Disease Ontology:DOID:0112067); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:66495); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "23576753;23806337;31219806;34428180;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUR9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0F1-1", "uniprot_id": [ { "id": "NDC80_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0F1", "type": "external" } ], "mass": 73962.0, "length": 642, "protein_name": "Kinetochore protein NDC80 homolog", "gene_name": "Ndc80", "organism": "Mouse", "refseq_name": "kinetochore protein NDC80 homolog", "refseq_ac": [ { "id": "NP_075783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075783", "type": "external" } ], "gene_names_uniprotkb": "Ndc80; Hec1; Kntc2", "gene_names_refseq": "2610020P18Rik; HEC1; HEC; Kntc2; Ndc80", "protein_names_uniprotkb": "Kinetochore protein NDC80 homolog; Kinetochore protein Hec1; Kinetochore-associated protein 2", "protein_names_refseq": "NDC80 homolog, kinetochore complex component; highly expressed in cancer, rich in leucine heptad repeats; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:67052); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "11266451;21183079;21750661;22872234;28843857;30059200;31219806;32461611;34203471;34428180;36210013;9315664", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; These data strongly indicated that KNTC2 is a promising target for the treatment of HCC and that phosphorylated HH3 at serine 10 is one of the target engagement markers for KNTC2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQT6;Q3UWM5;Q99P70", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0030332 cyclin binding;GO:0140483 kinetochore adaptor activity", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D0F1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES74-1", "uniprot_id": [ { "id": "NEK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES74", "type": "external" } ], "mass": 34537.0, "length": 302, "protein_name": "Serine/threonine-protein kinase Nek7", "gene_name": "Nek7", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek7 isoform 2", "refseq_ac": [ { "id": "NP_001298077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298077", "type": "external" } ], "gene_names_uniprotkb": "Nek7", "gene_names_refseq": "2810460C19Rik; Nek7", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek7; 2.7.11.34; Never in mitosis A-related kinase 7; NimA-related protein kinase 7", "protein_names_refseq": "NIMA-related expressed kinase 7; NIMA-related kinase 7; never in mitosis A-related kinase 7; nimA-related protein kinase 7; serine/threonine-protein kinase Nek7 isoform 2; serine/threonine-protein kinase Nek7", "tax_id": 10090, "disease": "", "pathway": " (mmu:59125)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10964517;11744387;20473324;26188091;26553871;26642356;26814970;28135057;31599954;34428180;37575012;38092000;38408556;41066511", "class_list": "", "function": "During early embryogenesis nek7 is expressed in the site of decidual reaction. Later in embryogenesis, nek7 is highly expressed in the dorsal thalamus., [RefSeq, PubMed]; MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome activation., [RefSeq, PubMed]; Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:20473324). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:20473324). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:26814970). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26553871, PubMed:26642356, PubMed:26814970). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:26814970)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Silencing of METTL3 inhibits m6A methylation of NEK7 to suppress pyrolysis in an HT-22 cell-based model of intracerebral hemorrhage., [RefSeq, PubMed]; ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEV7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0032741 positive regulation of interleukin-18 production;GO:0044546 NLRP3 inflammasome complex assembly;GO:0006468 protein phosphorylation;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9ES74-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHW2-1", "uniprot_id": [ { "id": "NIT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHW2", "type": "external" } ], "mass": 30502.0, "length": 276, "protein_name": "Omega-amidase NIT2", "gene_name": "Nit2", "organism": "Mouse", "refseq_name": "omega-amidase NIT2", "refseq_ac": [ { "id": "NP_075664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075664", "type": "external" } ], "gene_names_uniprotkb": "Nit2; D16Ertd502e", "gene_names_refseq": "1190017B19Rik; D16Ertd502e; Nit2", "protein_names_uniprotkb": "Omega-amidase NIT2; 3.5.1.3; Nitrilase homolog 2", "protein_names_refseq": "Nit protein 2; nitrilase homolog 2; omega-amidase NIT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52633); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10959838;19053248;19595734;19596042;21750661;21952136;23576753;23806337;25428506;28373563;30084848;30779550;31219806;34428180;35820727;37453647;37507081;39927985", "class_list": "", "function": "Data conclude that mammalian nitrilase 2 is omega-amidase., [RefSeq, PubMed]; Has omega-amidase activity (PubMed:19596042, PubMed:28373563). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19596042). Can also hydrolyze gamma-monomethyl-alpha-ketoglutarate in vitro (PubMed:19596042)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTG9", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0050152 omega-amidase activity;GO:0106008 2-oxoglutaramate amidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006528 asparagine metabolic process;GO:0006107 oxaloacetate metabolic process;GO:0006541 glutamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9JHW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11725-1", "uniprot_id": [ { "id": "OTC_MOUSE", "url": "https://www.uniprot.org/uniprot/P11725", "type": "external" } ], "mass": 39765.0, "length": 354, "protein_name": "Ornithine transcarbamylase, mitochondrial", "gene_name": "Otc", "organism": "Mouse", "refseq_name": "ornithine transcarbamylase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_032795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032795", "type": "external" } ], "gene_names_uniprotkb": "Otc", "gene_names_refseq": "Otc; Sf; spf", "protein_names_uniprotkb": "Ornithine transcarbamylase, mitochondrial; 2.1.3.3; OTCase; Ornithine carbamoyltransferase, mitochondrial", "protein_names_refseq": "OTCase; ornithine carbamoyltransferase, mitochondrial; ornithine transcarbamylase, mitochondrial isoform 1 precursor; ornithine transcarbamylase, mitochondrial", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); cholestasis (Disease Ontology:DOID:13580); hepatocellular carcinoma (Disease Ontology:DOID:684); ornithine carbamoyltransferase deficiency (Disease Ontology:DOID:9271); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18416); (R-MMU-1268020); (R-MMU-70635)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "23576753;23806337;2831503;30084848;3011788;33228018;34428180;3603027;37453647", "class_list": "", "function": "An Exon-Specific Small Nuclear U1 RNA (ExSpeU1) Improves Hepatic OTC Expression in a Splicing-Defective spf/ash Mouse Model of Ornithine Transcarbamylase Deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.1.98.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.98.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0004585 ornithine carbamoyltransferase activity;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019240 citrulline biosynthetic process;GO:0055081 monoatomic anion homeostasis;GO:0006591 ornithine metabolic process;GO:0006593 L-ornithine catabolic process;GO:0097272 ammonium homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11725-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22091-1", "uniprot_id": [ { "id": "TAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P22091", "type": "external" } ], "mass": 34279.0, "length": 329, "protein_name": "T-cell acute lymphocytic leukemia protein 1 homolog", "gene_name": "Tal1", "organism": "Mouse", "refseq_name": "T-cell acute lymphocytic leukemia protein 1 homolog", "refseq_ac": [ { "id": "NP_001274317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274317", "type": "external" } ], "gene_names_uniprotkb": "Tal1; Scl; Tal-1", "gene_names_refseq": "Hpt; SCL/tal-1; Scl; Tal1; bHLHa17; tal-1", "protein_names_uniprotkb": "T-cell acute lymphocytic leukemia protein 1 homolog; Stem cell protein; TAL-1", "protein_names_refseq": "T-cell acute lymphocytic leukemia protein 1 homolog; stem cell protein", "tax_id": 10090, "disease": "lymphoid leukemia (Disease Ontology:DOID:1037); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:21349); (R-MMU-8939236)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10527940;11904294;16407974;1704135;21183079;21750661;23980096;31018977;34203471;9391090", "class_list": "", "function": "Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0043249 erythrocyte maturation;GO:0035162 embryonic hemopoiesis;GO:0030221 basophil differentiation;GO:0060217 hemangioblast cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P22091-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03350-1", "uniprot_id": [ { "id": "TSP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03350", "type": "external" } ], "mass": 129882.0, "length": 1172, "protein_name": "Thrombospondin-2", "gene_name": "Thbs2", "organism": "Mouse", "refseq_name": "thrombospondin-2 precursor", "refseq_ac": [ { "id": "NP_035711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035711", "type": "external" } ], "gene_names_uniprotkb": "Thbs2; Tsp2", "gene_names_refseq": "TSP2; Thbs-2; Thbs2", "protein_names_uniprotkb": "Thrombospondin-2", "protein_names_refseq": "Thrombospondin-2; thrombospondin-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:21826); (R-MMU-186797); (R-MMU-5173214)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1371115;15748999;1712771;20173027;30899004;31599954;36645109;38433265;39122122", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties., [UniProtKB, PubMed]; Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration., [RefSeq, PubMed]; Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice., [RefSeq, PubMed]; Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8CG21", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0031091 platelet alpha granule;GO:1990341 thrombospondin complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0051965 positive regulation of synapse assembly;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q03350-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K296-1", "uniprot_id": [ { "id": "MTMR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K296", "type": "external" } ], "mass": 133840.0, "length": 1196, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3", "gene_name": "Mtmr3", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform 1", "refseq_ac": [ { "id": "NP_001360826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001360826", "type": "external" } ], "gene_names_uniprotkb": "Mtmr3", "gene_names_refseq": "1700092A20Rik; FYVE-DSP1; Mtmr3; ZFYVE10; mKIAA0371", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; 3.1.3.95; Myotubularin-related protein 3; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (mmu:74302); (R-MMU-1632852); (R-MMU-1660499)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;26495903;26740625;28011936;30084848;30944173;31219806;34428180;35984892;37414396;37828378", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic. Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis., [UniProtKB, UniProtKB]; MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy., [RefSeq, PubMed]; These results suggest that MTMR3 and MTMR4 regulate the production of PtdIns3P, which plays a critical role in suppressing DNA-mediated innate immune responses via modulating STING trafficking., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCA4", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019903 protein phosphatase binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0006470 protein dephosphorylation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K296-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28184-1", "uniprot_id": [ { "id": "MT3_MOUSE", "url": "https://www.uniprot.org/uniprot/P28184", "type": "external" } ], "mass": 7009.0, "length": 68, "protein_name": "Metallothionein-3", "gene_name": "Mt3", "organism": "Mouse", "refseq_name": "metallothionein-3", "refseq_ac": [ { "id": "NP_038631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038631", "type": "external" } ], "gene_names_uniprotkb": "Mt3", "gene_names_refseq": "Mt-3; Mt3", "protein_names_uniprotkb": "Metallothionein-3; GIF; Growth inhibitory factor; MT-3; MT-III; Metallothionein-III", "protein_names_refseq": "GIF; MT-III; growth inhibitory factor; metallothionein-3; metallothionein-III", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); psychotic disorder (Disease Ontology:DOID:2468); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); multiple system atrophy (Disease Ontology:DOID:4752); borna disease (Disease Ontology:DOID:5154); median neuropathy (Disease Ontology:DOID:571)", "pathway": " (mmu:17751); (R-MMU-5661231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11560491;1631128;21183079;21750661;38904023;8039715", "class_list": "", "function": "Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity)., [UniProtKB]; Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation. Publication Status: Online-Only, [RefSeq, PubMed]; Metallothioneins have a high content of cysteine residues that bind various heavy metals., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:2000296 negative regulation of hydrogen peroxide catabolic process;GO:0006829 zinc ion transport;GO:0001934 positive regulation of protein phosphorylation;GO:0006979 response to oxidative stress;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28184-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXA1-1", "uniprot_id": [ { "id": "GOLI4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXA1", "type": "external" } ], "mass": 76785.0, "length": 655, "protein_name": "Golgi integral membrane protein 4", "gene_name": "Golim4", "organism": "Mouse", "refseq_name": "Golgi integral membrane protein 4 isoform 2", "refseq_ac": [ { "id": "NP_780402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780402", "type": "external" } ], "gene_names_uniprotkb": "Golim4; Df10; Golph4", "gene_names_refseq": "3110027H23Rik; GIMPC; GPP130; Golim4; Golph4; P138", "protein_names_uniprotkb": "Golgi integral membrane protein 4; Decapacitation factor 10; Golgi phosphoprotein 4", "protein_names_refseq": "Golgi integral membrane protein 4 isoform 2; decapacitation factor 10; golgi phosphoprotein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:73124)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16221991;18034455;21750661;34428180;37828378", "class_list": "", "function": "Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWP9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0010008 endosome membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BXA1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERS5-1", "uniprot_id": [ { "id": "PKHA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERS5", "type": "external" } ], "mass": 47380.0, "length": 425, "protein_name": "Pleckstrin homology domain-containing family A member 2", "gene_name": "Plekha2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family A member 2 isoform 1", "refseq_ac": [ { "id": "NP_112547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112547", "type": "external" } ], "gene_names_uniprotkb": "Plekha2; Tapp2", "gene_names_refseq": "6430512N22Rik; Plekha2; TAPP2", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 2; PH domain-containing adaptor PHAD47; PH domain-containing family A member 2; TAPP-2; Tandem PH domain-containing protein 2", "protein_names_refseq": "PH domain-containing adaptor PHAD47; PH domain-containing family A member 2; pleckstrin homology domain-containing family A member 2 isoform 1; pleckstrin homology domain-containing family A member 2; pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2andem PH Domain containing protein 2; tandem PH domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:83436); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11001876;11802782;12101241;14516276;17242355;21750661;22777911;25428506;26495903;27859053;34428180;39627609", "class_list": "", "function": "Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation and autoantibody production, [RefSeq, PubMed]; This study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY29", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0043236 laminin binding;GO:0030165 PDZ domain binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001954 positive regulation of cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9ERS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09110-1", "uniprot_id": [ { "id": "MP2K3_MOUSE", "url": "https://www.uniprot.org/uniprot/O09110", "type": "external" } ], "mass": 39296.0, "length": 347, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 3", "gene_name": "Map2k3", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 3", "refseq_ac": [ { "id": "NP_032954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032954", "type": "external" } ], "gene_names_uniprotkb": "Map2k3; Mkk3; Prkmk3", "gene_names_refseq": "MAPKK 3; MEK3; MKK3b; MKK3; Map2k3; Prkmk3", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 3; 2.7.12.2; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MEK 3", "protein_names_refseq": "MAP kinase kinase 3; MAPK/ERK kinase 3; dual specificity mitogen-activated protein kinase kinase 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); restrictive cardiomyopathy (Disease Ontology:DOID:397); cervical cancer (Disease Ontology:DOID:4362); retinal disease (Disease Ontology:DOID:5679); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (mmu:26397); (R-MMU-2559580); (R-MMU-450302)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14634666;21183079;21750661;25153642;25428506;37507081;39197168;8900184", "class_list": "", "function": "Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis., [RefSeq, PubMed]; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97293;Q91VX1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004708 MAP kinase kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:1904784 NLRP1 inflammasome complex assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O09110-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8N6-1", "uniprot_id": [ { "id": "LIN37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8N6", "type": "external" } ], "mass": 28378.0, "length": 246, "protein_name": "Protein lin-37 homolog", "gene_name": "Lin37", "organism": "Mouse", "refseq_name": "protein lin-37 homolog isoform 2", "refseq_ac": [ { "id": "NP_001277498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277498", "type": "external" } ], "gene_names_uniprotkb": "Lin37", "gene_names_refseq": "1810054G18Rik; Lin37", "protein_names_uniprotkb": "Protein lin-37 homolog; Antolefinine; Antolefinin", "protein_names_refseq": "antolefinine; protein lin-37 homolog isoform 2; protein lin-37 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75660); (R-MMU-1538133)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "18250455;19224205;20173027;21183079;21750661;21952136;25428506;25428507;25605945;28920576;30084848;31219806;34428180", "class_list": "", "function": "Thus, Lin37 is an essential component of DREAM complex that cooperates with Rb to induce quiescence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0031523 Myb complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045023 G0 to G1 transition;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D8N6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMK9-1", "uniprot_id": [ { "id": "HNRPQ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMK9", "type": "external" } ], "mass": 69633.0, "length": 623, "protein_name": "Heterogeneous nuclear ribonucleoprotein Q", "gene_name": "Syncrip", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein Q isoform 3", "refseq_ac": [ { "id": "NP_001271257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271257", "type": "external" } ], "gene_names_uniprotkb": "Syncrip; Hnrpq; Nsap1l; Nsap1", "gene_names_refseq": "2610109K23Rik; 4632417O19Rik; GRY-RBP; Nsap1l; Nsap1; Syncrip; hnRNP Q; pp68", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein Q; GRY-RBP; Glycine- and tyrosine-rich RNA-binding protein; NS1-associated protein 1; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; hnRNP Q; pp68", "protein_names_refseq": "NS1-associated protein 1; RRM RNA binding protein GRY-RBP; glycine- and tyrosine-rich RNA-binding protein; heterogeneous nuclear ribonucleoprotein Q isoform 3; heterogeneous nuclear ribonucleoprotein Q; hnRNP-Q", "tax_id": 10090, "disease": "", "pathway": " (mmu:56403)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10734137;11773003;11994298;19470752;21750661;22645316;25153642;26495903;28135057;28528544;29187734;30779550;34428180;36288343;37085479;37453647;37507081;37828378;9847309", "class_list": "", "function": "Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins., [UniProtKB]; RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88991;Q2YDV8;Q68ED6;Q80YV6;Q8BGP1;Q8C5K6;Q8CGC2;Q91ZR0;Q99KU9;Q9QYF4", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0048027 mRNA 5'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q7TMK9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03385-1", "uniprot_id": [ { "id": "GNDS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03385", "type": "external" } ], "mass": 94202.0, "length": 852, "protein_name": "Ral guanine nucleotide dissociation stimulator", "gene_name": "Ralgds", "organism": "Mouse", "refseq_name": "ral guanine nucleotide dissociation stimulator isoform 3", "refseq_ac": [ { "id": "NP_033084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033084", "type": "external" } ], "gene_names_uniprotkb": "Ralgds; Rgds", "gene_names_refseq": "Gnds; Ralgds; Rgds; mKIAA1308", "protein_names_uniprotkb": "Ral guanine nucleotide dissociation stimulator; Ral guanine nucleotide exchange factor; RalGDS; RalGEF", "protein_names_refseq": "ral guanine nucleotide dissociation stimulator isoform 3; ral guanine nucleotide exchange factor; ralGEF", "tax_id": 10090, "disease": "", "pathway": " (mmu:19730); (R-MMU-171007); (R-MMU-5673001)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11748241;16580637;21750661;23473774;27773821;34428180;35820727;8094051", "class_list": "", "function": "Data implicate RalGDS-mediated induction of autophagy and exocyst function as a critical feature of load-induced cardiac hypertrophy., [RefSeq, PubMed]; Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (PubMed:27773821). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (By similarity)., [UniProtKB, PubMed, UniProtKB]; In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS at Y752 in its RBD, which blocks the binding of Ras to RalGDS., [RefSeq, PubMed]; We investigated the activation of RalGDS, one of the Ras effector proteins with guanine-nucleotide exchange factor activity for Ral., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R077", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03385-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEM8-1", "uniprot_id": [ { "id": "S25A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEM8", "type": "external" } ], "mass": 39632.0, "length": 357, "protein_name": "Solute carrier family 25 member 3", "gene_name": "Slc25a3", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_598429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598429", "type": "external" } ], "gene_names_uniprotkb": "Slc25a3", "gene_names_refseq": "5730556H19Rik; PTP; Phc; Slc25a3", "protein_names_uniprotkb": "Solute carrier family 25 member 3; PTP; Phosphate carrier protein, mitochondrial; Phosphate transport protein", "protein_names_refseq": "adenine nucleotide translocator), member 3; phosphate carrier protein, mitochondrial; phosphate transport protein; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 member 3 isoform 1 precursor", "tax_id": 10090, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:18674)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "21750661;23034391;23576753;23806337;26495903;29237729;30084848;31219806;33300544;34428180;35820727;35984892;36288343;37453647;37507081;38552738;38897394;39627609;39927985", "class_list": "", "function": "Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis., [RefSeq, PubMed]; SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3., [RefSeq, PubMed]; The results indicated that miR-141 can regulate Slc25a3 protein expression in the diabetic heart. Further, diabetes-induced miRNA changes may influence mitochondrial proteomes and functional processes such as mitochondrial ATP production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542V7", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005315 phosphate transmembrane transporter activity;GO:0015317 phosphate:proton symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0035435 phosphate ion transmembrane transport;GO:1990547 mitochondrial phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8VEM8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CW79-1", "uniprot_id": [ { "id": "GOGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CW79", "type": "external" } ], "mass": 87338.0, "length": 758, "protein_name": "Golgin subfamily A member 1", "gene_name": "Golga1", "organism": "Mouse", "refseq_name": "golgin subfamily A member 1 isoform b", "refseq_ac": [ { "id": "NP_001277578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277578", "type": "external" } ], "gene_names_uniprotkb": "Golga1", "gene_names_refseq": "0710001G09Rik; 2210418B03Rik; Golga1; Golgi97; awag; golgin-97", "protein_names_uniprotkb": "Golgin subfamily A member 1; Golgin-97", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 1; golgin subfamily A member 1 isoform b; golgin subfamily A member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76899); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11412037;17242355;21183079;21750661;29084197;34428180", "class_list": "", "function": "Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9343, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3KGQ9;Q80YB0", "ec_number_list": [], "go_molecular_function": "GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0001669 acrosomal vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0070633 transepithelial transport;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CW79-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LI8-1", "uniprot_id": [ { "id": "HGS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LI8", "type": "external" } ], "mass": 86015.0, "length": 775, "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "Hgs", "organism": "Mouse", "refseq_name": "hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1", "refseq_ac": [ { "id": "NP_001152800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152800", "type": "external" } ], "gene_names_uniprotkb": "Hgs; Hrs", "gene_names_refseq": "Hgr; Hgs; Hrs; ZFYVE8; tn", "protein_names_uniprotkb": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "protein_names_refseq": "hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1; hepatocyte growth factor-regulated tyrosine kinase substrate", "tax_id": 10090, "disease": "", "pathway": " (mmu:15239); (R-MMU-182971); (R-MMU-432720); (R-MMU-5689880); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9013420); (R-MMU-917729); (R-MMU-9706019)", "pathway_count": 10, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10364163;10651905;11094085;11493665;11988743;12802020;12953068;15592455;16159959;17947660;18034455;19278655;21750661;23806337;25428506;25605945;26495903;26740625;27802388;30084848;31599954;32848054;34428180;35820727;36852467;40021952;40885482;7565774;9407053;9630564", "class_list": "", "function": "Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q61691;Q8BQW3", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0033565 ESCRT-0 complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0010324 membrane invagination;GO:0010628 positive regulation of gene expression;GO:0031623 receptor internalization;GO:0008333 endosome to lysosome transport;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q99LI8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53690-1", "uniprot_id": [ { "id": "MMP14_MOUSE", "url": "https://www.uniprot.org/uniprot/P53690", "type": "external" } ], "mass": 65919.0, "length": 582, "protein_name": "Matrix metalloproteinase-14", "gene_name": "Mmp14", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-14 preproprotein", "refseq_ac": [ { "id": "NP_032634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032634", "type": "external" } ], "gene_names_uniprotkb": "Mmp14; Mtmmp", "gene_names_refseq": "MMP-X1; MT-MMP-1; MT1-MMP; Mmp14; sabe", "protein_names_uniprotkb": "Matrix metalloproteinase-14; 3.4.24.80; MMP-14; MMP-X1; MT-MMP 1; MT-MMP; MT1-MMP; MT1MMP; MTMMP1; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase", "protein_names_refseq": "Membrane type 1-MMP; matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase-14 preproprotein; membrane-type-1 matrix metalloproteinase; type 1 matrix metalloprotease 14", "tax_id": 10090, "disease": "Winchester syndrome (Disease Ontology:DOID:0080696); intracranial aneurysm (Disease Ontology:DOID:10941); diabetic angiopathy (Disease Ontology:DOID:11713); dilated cardiomyopathy (Disease Ontology:DOID:12930); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); transitional cell carcinoma (Disease Ontology:DOID:2671); IgA glomerulonephritis (Disease Ontology:DOID:2986); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (mmu:17387); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-9839383)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10520996;10737763;16778201;18250455;21750661;26495903;26740625;35177851;37828378;38990714;7708715;9325265;9648071", "class_list": "", "function": "Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:10520996, PubMed:10737763). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996, PubMed:10737763). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:10737763). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed:35177851)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL., [UniProtKB, UniProtKB]; Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival., [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08645;O35369;Q8BTX2", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0097094 craniofacial suture morphogenesis;GO:1905523 positive regulation of macrophage migration;GO:0071412 cellular response to genistein;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53690-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD04-1", "uniprot_id": [ { "id": "GRAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD04", "type": "external" } ], "mass": 92715.0, "length": 806, "protein_name": "GRIP1-associated protein 1", "gene_name": "Gripap1", "organism": "Mouse", "refseq_name": "GRIP1-associated protein 1 isoform 2", "refseq_ac": [ { "id": "NP_997553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997553", "type": "external" } ], "gene_names_uniprotkb": "Gripap1; DXImx47e; Kiaa1167", "gene_names_refseq": "DXImx47e; GRASP-1; Gripap1; Sfc10; mKIAA1167", "protein_names_uniprotkb": "GRIP1-associated protein 1; 30kDa C-terminus form; GRASP-1; HCMV-interacting protein", "protein_names_refseq": "GRIP1-associated protein 1 isoform 2; HCMV-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:54645)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17242355;20098723;21183079;21750661;26495903;40885482", "class_list": "", "function": "Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity (By similarity)., [UniProtKB, UniProtKB]; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AEW7;O35693;Q3T9C3;Q69ZP9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0015031 protein transport;GO:1903828 negative regulation of protein localization;GO:0099152 regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0099158 regulation of recycling endosome localization within postsynapse;GO:1903910 negative regulation of receptor clustering", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VD04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZX7-1", "uniprot_id": [ { "id": "LRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZX7", "type": "external" } ], "mass": 504742.0, "length": 4545, "protein_name": "Prolow-density lipoprotein receptor-related protein 1", "gene_name": "Lrp1", "organism": "Mouse", "refseq_name": "prolow-density lipoprotein receptor-related protein 1 precursor", "refseq_ac": [ { "id": "NP_032538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032538", "type": "external" } ], "gene_names_uniprotkb": "Lrp1; A2mr", "gene_names_refseq": "A2mr; CD91; Lrp1; Lrp; b2b1554Clo", "protein_names_uniprotkb": "Prolow-density lipoprotein receptor-related protein 1; A2MR; Alpha-2-macroglobulin receptor; LRP-1", "protein_names_refseq": "LRP-1; alpha 2-macroglobulin receptor; prolow-density lipoprotein receptor-related protein 1 precursor; prolow-density lipoprotein receptor-related protein 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); omphalocele (Disease Ontology:DOID:0060327); keratosis pilaris atrophicans (Disease Ontology:DOID:0080751); Alzheimer's disease (Disease Ontology:DOID:10652); gastroschisis (Disease Ontology:DOID:11044); sciatic neuropathy (Disease Ontology:DOID:11446); alcoholic hepatitis (Disease Ontology:DOID:12351); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); myocardial infarction (Disease Ontology:DOID:5844); prostate carcinoma in situ (Disease Ontology:DOID:8634); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:16971); (R-MMU-2168880); (R-MMU-975634)", "pathway_count": 3, "publication_count": 38, "publication_id_list": "10.1101/2023.09.13.557529;10772929;11247302;11465105;12151109;1423604;15135046;1618748;18276581;19144319;19224205;19349973;19656770;20173027;21750661;23806337;25428506;26192747;26495903;26740625;27802388;28011936;30084848;30779550;30899004;31219806;32296178;33300544;34428180;35820727;35984892;36067312;36210013;37828378;39950214;40021952;40885482;8485155", "class_list": "", "function": "(Microbial infection) Functions as a receptor for Vibrio cholerae cholix toxin and for Pseudomonas aeruginosa exotoxin A., [UniProtKB, PubMed, PubMed]; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development (PubMed:1423604). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor (By similarity). Acts as a TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (By similarity). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 37, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 37, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 37, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 37, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 52, "disease_count": 13, "glyco_site_count": 60, "binding_glycan_count": 0, "secondary_ac_list": "Q61291;Q920Y4", "ec_number_list": [], "go_molecular_function": "GO:0016964 alpha-2 macroglobulin receptor activity;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0034185 apolipoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0032370 positive regulation of lipid transport;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:1904109 positive regulation of cholesterol import", "synthesized_glycan_count": 0, "hit_score": 13.6, "record_id": "Q91ZX7-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1PSW8-1", "uniprot_id": [ { "id": "LIN41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1PSW8", "type": "external" } ], "mass": 92054.0, "length": 855, "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "Trim71", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM71", "refseq_ac": [ { "id": "NP_001035968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035968", "type": "external" } ], "gene_names_uniprotkb": "Trim71; Gm1127; Lin41", "gene_names_refseq": "2610206G21Rik; 636931; Gm1127; Lin41; Trim71; lin-41; mLin41; mlin-41", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM71; 2.3.2.27; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71; mLin41", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM71; RING-type E3 ubiquitin transferase TRIM71; protein lin-41 homolog; tripartite motif-containing protein 71", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:636931); (R-MMU-983168)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16245339;16247770;16477647;19098426;19898466;22508726;22735451;23125361;25883935;36852467;37492931;38036331", "class_list": "", "function": "E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451). Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Lin-41 is genetically and biochemically downstream of both the Shh and Fgf signaling pathways and is expressed in three phases over developmental time and most notably is associated with the developing autopod., [RefSeq, PubMed]; Lin-41 is temporally regulated by miRNAs in order to direct key developmental events such as limb formation., [RefSeq, PubMed]; Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein. Erratum:[Sci Bull (Beijing). 2025 Sep 30;70(18):3090. doi: 10.1016/j.scib.2025.04.001. PMID: 40221318], [RefSeq, PubMed]; TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0030371 translation repressor activity;GO:0035198 miRNA binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0060964 regulation of miRNA-mediated gene silencing;GO:0010608 post-transcriptional regulation of gene expression;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0001843 neural tube closure;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q1PSW8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI56-1", "uniprot_id": [ { "id": "LRP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI56", "type": "external" } ], "mass": 211954.0, "length": 1905, "protein_name": "Low-density lipoprotein receptor-related protein 4", "gene_name": "Lrp4", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001139329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139329", "type": "external" } ], "gene_names_uniprotkb": "Lrp4; Kiaa0816", "gene_names_refseq": "6430526J12Rik; D230026E03; Lrp4; Megf7; mdig", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 4; LDLR dan; LRP-4", "protein_names_refseq": "LDLR dan; LRP-4; low-density lipoprotein receptor-related protein 4 isoform 2 precursor", "tax_id": 10090, "disease": "sclerosteosis 2 (Disease Ontology:DOID:0060757); bone development disease (Disease Ontology:DOID:0080006); Cenani-Lenz syndactyly syndrome (Disease Ontology:DOID:0090015); congenital myasthenic syndrome 17 (Disease Ontology:DOID:0110674)", "pathway": " (mmu:228357)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16207730;16517118;18848351;21471202;24140340;30899004;34428180;38051321", "class_list": "", "function": "An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling., [RefSeq, PubMed]; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation (PubMed:16517118)., [UniProtKB, PubMed, PubMed, PubMed]; Modulator of cellular signaling pathways involving Wnt proteins, bone morphogenetic proteins, fibroblast growth factors and sonic hedgehog homolog., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AGT4;Q8BPX5;Q8CBB3;Q8CCP5", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0097104 postsynaptic membrane assembly;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0006897 endocytosis;GO:0050808 synapse organization;GO:0051124 synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8VI56-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55033-1", "uniprot_id": [ { "id": "NCK2_MOUSE", "url": "https://www.uniprot.org/uniprot/O55033", "type": "external" } ], "mass": 42879.0, "length": 380, "protein_name": "Cytoplasmic protein NCK2", "gene_name": "Nck2", "organism": "Mouse", "refseq_name": "cytoplasmic protein NCK2", "refseq_ac": [ { "id": "NP_035009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035009", "type": "external" } ], "gene_names_uniprotkb": "Nck2; Grb4", "gene_names_refseq": "4833426I10Rik; Grb4; NCKbeta; Nck-2; Nck2", "protein_names_uniprotkb": "Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta", "protein_names_refseq": "NCK adaptor protein 2; SH2/SH3 adaptor protein NCK-beta; cytoplasmic protein NCK2; growth factor receptor-bound protein 4", "tax_id": 10090, "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651); autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:17974); (R-MMU-186763); (R-MMU-373753); (R-MMU-3928664); (R-MMU-4420097); (R-MMU-9013420); (R-MMU-9013424)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11557983;15345747;17947660;18034455;21183079;21750661;37479911", "class_list": "", "function": "Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling., [UniProtKB, UniProtKB]; Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development. Publication Status: Online-Only, [RefSeq, PubMed]; Transduces B-ephrin reverse signals., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0044877 protein-containing complex binding;GO:0030971 receptor tyrosine kinase binding;GO:0097110 scaffold protein binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O55033-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIL4-1", "uniprot_id": [ { "id": "NHRF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIL4", "type": "external" } ], "mass": 56499.0, "length": 519, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3", "gene_name": "Pdzk1", "organism": "Mouse", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3", "refseq_ac": [ { "id": "NP_001139473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139473", "type": "external" } ], "gene_names_uniprotkb": "Pdzk1; Cap70; Nherf3", "gene_names_refseq": "1700023D20Rik; 2610507N21Rik; 4921513F16Rik; D3Ertd537e; NHERF-3; Nherf3; Pdzd1; Pdzk1; mPDZK1; naPi-Cap1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3; CFTR-associated protein of 70 kDa; NHERF-3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3", "protein_names_refseq": "CFTR-associated protein of 70 kDa; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; PDZ domain-containing protein 1; na/Pi cotransporter C-terminal-associated protein 1; sodium-hydrogen exchanger regulatory factor 3", "tax_id": 10090, "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078)", "pathway": " (mmu:59020)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11051556;11099500;12556478;14531806;15523054;16141316;17242355;20739281;21183079;21602281;21750661;23457445;30084848;34428180;37159505;38158021;39019845", "class_list": "", "function": "A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Downregulation of PDZK1 by TGF-beta1 promotes renal fibrosis via inducing epithelial-mesenchymal transition of renal tubular cells., [RefSeq, PubMed]; PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function. Publication Status: Online-Only, [RefSeq, PubMed]; The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells., [RefSeq, PubMed]; While PDZK1-deficient mice developed normally, did not display any gross phenotypic abnormalities, and were fecund, lack of PDZK1 resulted in modulation of expression of selective ion channels in the kidney, as well as increased serum cholesterol levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDP5;Q8R4G2;Q9CQ72", "ec_number_list": [], "go_molecular_function": "GO:0005124 scavenger receptor binding;GO:0005102 signaling receptor binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0072659 protein localization to plasma membrane;GO:0090314 positive regulation of protein targeting to membrane;GO:0044070 regulation of monoatomic anion transport;GO:1902603 carnitine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9JIL4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1HFZ0-1", "uniprot_id": [ { "id": "NSUN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1HFZ0", "type": "external" } ], "mass": 85452.0, "length": 757, "protein_name": "RNA cytosine C(5)-methyltransferase NSUN2", "gene_name": "Nsun2", "organism": "Mouse", "refseq_name": "RNA cytosine C(5)-methyltransferase NSUN2", "refseq_ac": [ { "id": "NP_663329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663329", "type": "external" } ], "gene_names_uniprotkb": "Nsun2; D13Wsu123e; Misu", "gene_names_refseq": "D13Wsu123e; Misu; Nsun2", "protein_names_uniprotkb": "RNA cytosine C(5)-methyltransferase NSUN2; 2.1.1.-; 2.1.1.203; Misu; Myc-induced SUN domain-containing protein; NOL1/NOP2/Sun domain family member 2; mRNA cytosine C(5)-methyltransferase; tRNA cytosine C(5)-methyltransferase", "protein_names_refseq": "Myc-induced SUN domain containing protein; NOL1/NOP2/Sun domain family 2; RNA cytosine C(5)-methyltransferase NSUN2; mRNA cytosine C(5)-methyltransferase; myc-induced SUN domain-containing protein; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 5 (Disease Ontology:DOID:0081181)", "pathway": " (mmu:28114)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16713953;17242355;19144319;19596847;21183079;21750661;22144916;22541562;22645316;22885326;23401851;23806337;23871666;28341602;29187734;31199786;31219806;31276587;31287866;34428180;34887587;35820727;39231094;39627609", "class_list": "", "function": "Misu is a novel downstream Myc target that methylates RNA polymerase III transcripts. Misu mediates Myc-induced cell proliferation and growth and is a potential target for cancer therapies. Erratum:[Curr Biol. 2007 Nov 20;17(22):2002], [RefSeq, PubMed]; NSUN2 is critical for mouse oocyte meiosis and early embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]; NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus., [RefSeq, PubMed]; RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:22144916, PubMed:23871666, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:22144916, PubMed:22885326, PubMed:23401851, PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:22885326, PubMed:23871666, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587, PubMed:31287866). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (By similarity). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (By similarity). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (By similarity). May act downstream of Myc to regulate epidermal cell growth and proliferation (PubMed:16713953). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP., [RefSeq, PubMed]; We identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0PJD6;Q3U972;Q8BPG9;Q8CDF9;Q91YX9", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.203", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.203", "type": "external" } ], "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0062152 mRNA (cytidine-5-)-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005819 spindle", "go_biological_process": "GO:0048820 hair follicle maturation;GO:0033313 meiotic cell cycle checkpoint signaling;GO:0001701 in utero embryonic development;GO:0006397 mRNA processing;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q1HFZ0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU56-1", "uniprot_id": [ { "id": "NLRC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU56", "type": "external" } ], "mass": 115993.0, "length": 1064, "protein_name": "Protein NLRC3", "gene_name": "Nlrc3", "organism": "Mouse", "refseq_name": "protein NLRC3 isoform 2", "refseq_ac": [ { "id": "NP_780756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780756", "type": "external" } ], "gene_names_uniprotkb": "Nlrc3", "gene_names_refseq": "CLR16.2; D230007K08Rik; Nlrc3; mFLJ00348", "protein_names_uniprotkb": "Protein NLRC3", "protein_names_refseq": "caterpillar 16.2; protein NLRC3 isoform 2; protein NLRC3", "tax_id": 10090, "disease": "", "pathway": " (mmu:268857)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22863753;24560620;27951586;37139806;37586455;38436712;38445794", "class_list": "", "function": "Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses during viral latency in B lymphocytes., [RefSeq, PubMed]; NLRC3 Participates in Inhibiting the Pulmonary Inflammatory Response of Sepsis-Induced Acute Lung Injury., [RefSeq, PubMed]; NLRC3 attenuates osteoclastogenesis by limiting TNFalpha[+] Th17 cell response in osteoporosis., [RefSeq, PubMed]; NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-kappaB p65/HIF-1alpha pathway. Review article, [RefSeq, PubMed]; NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB by interacting with the TLR signaling adaptor TRAF6, [RefSeq, PubMed]; NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING., [RefSeq, PubMed]; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (PubMed:22863753, PubMed:24560620). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (PubMed:27951586). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (By similarity). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3P6;Q3TAB7;Q8BJF4;Q8BV65", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0034451 centriolar satellite", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0032691 negative regulation of interleukin-1 beta production;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5DU56-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61066-1", "uniprot_id": [ { "id": "NR0B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61066", "type": "external" } ], "mass": 52576.0, "length": 472, "protein_name": "Nuclear receptor subfamily 0 group B member 1", "gene_name": "Nr0b1", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 0 group B member 1", "refseq_ac": [ { "id": "NP_031456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031456", "type": "external" } ], "gene_names_uniprotkb": "Nr0b1; Ahch; Dax1", "gene_names_refseq": "AHX; Ahch; Ahc; DAX-1; Dax1; Nr0b1; mDax1-134; mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297; mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337; mDax1-344; mDax1-38; mDax1-404; mDax1-472", "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1", "protein_names_refseq": "adrenal hypoplasia congenita-like protein; adrenal hypoplasia, congenital homolog; mDax1- 190; mDax1- 202; mDax1- 278; mDax1- 331; nuclear receptor DAX-1; nuclear receptor subfamily 0 group B member 1", "tax_id": 10090, "disease": "X-linked adrenal hypoplasia congenita (Disease Ontology:DOID:0080156); 46,XY sex reversal 2 (Disease Ontology:DOID:0111777)", "pathway": " (mmu:11614); (R-MMU-383280)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16466956;19015525;27601327;37248237;37261981;8756567;8921887", "class_list": "", "function": "Dax1 modulates ERalpha-dependent hypothalamic estrogen sensing in female mice. Publication Status: Online-Only, [RefSeq, PubMed]; Identification and Functional Evaluation of Alternative Splice Variants of Dax1 in Mouse Embryonic Stem Cells., [RefSeq, PubMed]; Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions (PubMed:19015525). Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis (By similarity). May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (PubMed:16466956)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes an orphan nuclear receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09068;O09147", "ec_number_list": [], "go_molecular_function": "GO:0032448 DNA hairpin binding;GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0007530 sex determination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61066-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62227-1", "uniprot_id": [ { "id": "NR0B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62227", "type": "external" } ], "mass": 28763.0, "length": 260, "protein_name": "Nuclear receptor subfamily 0 group B member 2", "gene_name": "Nr0b2", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 0 group B member 2", "refseq_ac": [ { "id": "NP_035980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035980", "type": "external" } ], "gene_names_uniprotkb": "Nr0b2; Shp", "gene_names_refseq": "Nr0b2; SHP-1; SHP; Shp1", "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 2; Orphan nuclear receptor SHP; Small heterodimer partner", "protein_names_refseq": "nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; small heterodimer partner", "tax_id": 10090, "disease": "alcoholic hepatitis (Disease Ontology:DOID:12351); intrahepatic cholestasis (Disease Ontology:DOID:1852); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:23957); (R-MMU-383280)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11964378;12949731;14752053;15707893;19390091;21262773;25212631;27412403;30555544;34428180;38088801;8650544", "class_list": "", "function": "SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay., [RefSeq, PubMed]; This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded orphan receptor lacks a DNA binding domain but modulates gene expression by interacting with other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]., [RefSeq]; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:8650544). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:8650544). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (PubMed:25212631). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (PubMed:30555544). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z53", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding;GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62227-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4B8-1", "uniprot_id": [ { "id": "NLRP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4B8", "type": "external" } ], "mass": 118275.0, "length": 1033, "protein_name": "NACHT, LRR and PYD domains-containing protein 3", "gene_name": "Nlrp3", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 3", "refseq_ac": [ { "id": "NP_665826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665826", "type": "external" } ], "gene_names_uniprotkb": "Nlrp3; Cias1; Mmig1; Nalp3; Pypaf1", "gene_names_refseq": "AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; MWS; Mmig1; NALP3; Nlrp3; Pypaf1", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 3; 3.6.4.-; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation-associated-inducible protein 1; PYRIN-containing APAF1-like protein 1", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; PYRIN-containing APAF1-like protein 1; cold autoinflammatory syndrome 1 protein homolog; cryopyrin; mast cell maturation-associated-inducible protein 1", "tax_id": 10090, "disease": "Muckle-Wells syndrome (Disease Ontology:DOID:0050854); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); autosomal dominant nonsyndromic deafness 34 (Disease Ontology:DOID:0080270); CINCA Syndrome (Disease Ontology:DOID:0090029); familial cold autoinflammatory syndrome 1 (Disease Ontology:DOID:0090062); alcoholic hepatitis (Disease Ontology:DOID:12351); urticaria (Disease Ontology:DOID:1555); myocardial infarction (Disease Ontology:DOID:5844); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:216799); (R-MMU-5689901); (R-MMU-844456)", "pathway_count": 3, "publication_count": 52, "publication_id_list": "14688236;15302403;16407888;16407889;16407890;16546100;17008311;17907925;18403674;19362020;20802146;20947763;21750661;22801494;22948162;23143333;23246432;23502856;23582325;23809161;23809162;24630723;24952504;24952505;25428506;26098997;26553871;26642356;26814970;27043286;27374331;27929086;28465465;28656979;28716882;28847925;28943315;30084848;30487600;30518920;30779550;31511697;34341353;34428180;34554188;34615873;34861190;35254907;36178239;37001519;39173637;40419769", "class_list": "", "function": "CIAS1 mRNA expression found primarily in peripheral blood leukocytes consistent with the postulated inflammatory function., [RefSeq, PubMed]; Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (PubMed:26098997). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (PubMed:26098997). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (PubMed:26098997). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (PubMed:26098997)., [UniProtKB, PubMed]; MMIG-1, a likely mouse PYPAF1 ortholog, may play a role in mast cell-directed inflammatory diseases, [RefSeq, PubMed]; Macrophages deficient in various components of the inflammasome such as caspase-1, ASC and NALP3 are defective in crystal-induced IL-1beta activation; insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, [RefSeq, PubMed]; Results reveal a critical role for cryopyrin (Cias1)in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes, [RefSeq, PubMed]; Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:19362020, PubMed:23582325, PubMed:26642356, PubMed:26814970, PubMed:27374331, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30518920, PubMed:36178239). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:19362020, PubMed:26642356, PubMed:26814970, PubMed:27374331, PubMed:28847925). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:16546100, PubMed:17008311, PubMed:26642356, PubMed:26814970, PubMed:27374331, PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. ATP released from necrotic cells triggers activation of NLRP3 inflammasome through P2RX7 signaling leading to neutrophil adhesion to the vascular endothelium close to the injury site (PubMed:20947763). Under resting conditions, ADP-bound NLRP3 is autoinhibited (By similarity). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407888, PubMed:16407889, PubMed:16407890, PubMed:18403674, PubMed:19362020, PubMed:37001519). Almost all stimuli trigger intracellular K(+) efflux (PubMed:23809161). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:26814970, PubMed:34615873, PubMed:34861190). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600). Shows ATPase activity (PubMed:34861190)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JQ87;Q1JQ88;Q6JEL0;T1W2H6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0070498 interleukin-1-mediated signaling pathway;GO:0032741 positive regulation of interleukin-18 production;GO:0002221 pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "Q8R4B8-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHL1-1", "uniprot_id": [ { "id": "NHRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHL1", "type": "external" } ], "mass": 37403.0, "length": 337, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2", "gene_name": "Nherf2", "organism": "Mouse", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform A", "refseq_ac": [ { "id": "NP_075542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075542", "type": "external" } ], "gene_names_uniprotkb": "Nherf2; Slc9a3r2", "gene_names_refseq": "0610011L07Rik; 1200011K07Rik; 2010007A20Rik; E3karp; NHERF-2; Nherf2; Octs2; Sip-1; Sip1; Slc9a3r2; Sryip1; Tka-1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein E3KARP; NHERF-2; Octs2; SIP-1; SRY-interacting protein 1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; TKA-1; Tyrosine kinase activator protein 1", "protein_names_refseq": "NHE3 kinase A regulatory protein E3KARP; Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform A; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; SRY-interacting protein 1; sodium-hydrogen exchanger regulatory factor 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; tyrosine kinase activator protein 1", "tax_id": 10090, "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:65962)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14531806;15665527;16166090;17242355;21183079;21750661;34428180;36288343;38533975", "class_list": "", "function": "CGMP-dependent kinase 2, Na[+]/H[+] exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains., [RefSeq, PubMed]; Demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3, [RefSeq, PubMed]; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDR3;Q6P074;Q8BGL9;Q8BW05;Q9DCR6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0007605 sensory perception of sound;GO:0034767 positive regulation of monoatomic ion transmembrane transport;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JHL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4R6-1", "uniprot_id": [ { "id": "NUP35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4R6", "type": "external" } ], "mass": 34786.0, "length": 325, "protein_name": "Nucleoporin NUP35", "gene_name": "Nup35", "organism": "Mouse", "refseq_name": "nucleoporin NUP35 isoform 2", "refseq_ac": [ { "id": "NP_001177108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177108", "type": "external" } ], "gene_names_uniprotkb": "Nup35; Mp44; Nup53", "gene_names_refseq": "2310006I24Rik; 35kDa; 5330402E05Rik; MP44; NO44; Nup35", "protein_names_uniprotkb": "Nucleoporin NUP35; 35 kDa nucleoporin; MP-44; Mitotic phosphoprotein 44; Nuclear pore complex protein Nup53; Nucleoporin NUP53", "protein_names_refseq": "35 kDa nucleoporin; mitotic phosphoprotein 44; nuclear pore complex protein Nup53; nucleoporin NUP35 isoform 2", "tax_id": 10090, "disease": "intestinal pseudo-obstruction (Disease Ontology:DOID:0080072)", "pathway": " (mmu:69482); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-9615933)", "pathway_count": 19, "publication_count": 24, "publication_id_list": "16962612;18299400;19144319;20484733;21183079;21606357;21750661;21952136;22645316;22872234;25428506;25605945;27427419;29237092;30059200;30195030;30779550;32782141;34203471;34428180;34678516;35820727;35822049;36852467", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity)., [UniProtKB]; Our study also raises the possibility that Nup35 polymorphisms could contribute to some cases of Chronic intestinal pseudo-obstruction, [RefSeq, PubMed]; The crystal structure of the Nup35 RNA-recognition motif (RRM) domain has been solved; the Nup35 RRM domain monomer adopts the characteristic betaalphabetabetaalphabeta topology revealing a new homodimerization mode., [RefSeq, PubMed]; The results suggest that Nup35 is putatively phosphorylated and released to the cytoplasm after resumption of meiosis, and it regulates spindle assembly and chromosome alignment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ATJ3;Q9D7J2", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:1990830 cellular response to leukemia inhibitory factor;GO:0051028 mRNA transport;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q8R4R6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61146-1", "uniprot_id": [ { "id": "OCLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61146", "type": "external" } ], "mass": 59000.0, "length": 521, "protein_name": "Occludin", "gene_name": "Ocln", "organism": "Mouse", "refseq_name": "occludin isoform 1", "refseq_ac": [ { "id": "NP_032782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032782", "type": "external" } ], "gene_names_uniprotkb": "Ocln; Ocl", "gene_names_refseq": "Ocln; Ocl", "protein_names_uniprotkb": "Occludin", "protein_names_refseq": "occludin isoform 1", "tax_id": 10090, "disease": "pseudo-TORCH syndrome 1 (Disease Ontology:DOID:0050656); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); transient cerebral ischemia (Disease Ontology:DOID:224); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:18260); (R-MMU-351906)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10026224;11102513;11502742;21183079;21750661;23239027;24588076;34428180;8601611", "class_list": "", "function": "May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544A7", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0030054 cell junction", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0070830 bicellular tight junction assembly;GO:0046326 positive regulation of D-glucose import;GO:0045216 cell-cell junction organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61146-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UWY1-1", "uniprot_id": [ { "id": "OOG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UWY1", "type": "external" } ], "mass": 57407.0, "length": 500, "protein_name": "Oogenesin-3", "gene_name": "Oog3", "organism": "Mouse", "refseq_name": "oogenesin-3", "refseq_ac": [ { "id": "NP_957710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_957710", "type": "external" } ], "gene_names_uniprotkb": "Oog3", "gene_names_refseq": "Oog3", "protein_names_uniprotkb": "Oogenesin-3", "protein_names_refseq": "oogenesin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100012)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14675769;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPT9", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UWY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIH2-1", "uniprot_id": [ { "id": "NUP50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIH2", "type": "external" } ], "mass": 49485.0, "length": 466, "protein_name": "Nuclear pore complex protein Nup50", "gene_name": "Nup50", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup50", "refseq_ac": [ { "id": "NP_057923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057923", "type": "external" } ], "gene_names_uniprotkb": "Nup50; Npap60", "gene_names_refseq": "1700030K07Rik; Npap60; Nup50", "protein_names_uniprotkb": "Nuclear pore complex protein Nup50; 50 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50", "protein_names_refseq": "50 kDa nucleoporin; nuclear pore associated protein 60 kDa; nuclear pore complex protein Nup50; nucleoporin Nup50; nucleoprotein 50", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:18141); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 18, "publication_id_list": "10811608;10891500;16222336;21183079;22645316;22872234;23806337;24943837;25153642;25428506;26515778;28135057;28528544;29187734;34887587;35820727;40885482;40997131", "class_list": "", "function": "Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:10811608). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:16222336). Interacts with regulatory proteins of cell cycle progression including CDKN1B (PubMed:10811608, PubMed:10891500). This interaction is required for correct intracellular transport and degradation of CDKN1B (PubMed:10811608)., [UniProtKB, PubMed, PubMed, PubMed]; Results suggest a transport-independent role for Nup50 in chromatin biology that occurs away from the NPC., [RefSeq, PubMed]; Results suggest that nucleoporin 50 plays an essential role in the survival of primordial germ cells during embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG43;Q3TN17;Q6P1F4;Q6PAL4;Q8C2Y6;Q9CU02;Q9JK85", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus;GO:0001841 neural tube formation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9JIH2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PSV9-1", "uniprot_id": [ { "id": "MDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5PSV9", "type": "external" } ], "mass": 184670.0, "length": 1707, "protein_name": "Mediator of DNA damage checkpoint protein 1", "gene_name": "Mdc1", "organism": "Mouse", "refseq_name": "mediator of DNA damage checkpoint protein 1 isoform a", "refseq_ac": [ { "id": "NP_001010833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010833", "type": "external" } ], "gene_names_uniprotkb": "Mdc1; Kiaa0170", "gene_names_refseq": "6820401C03; Mdc1; Nfbd1; mKIAA0170", "protein_names_uniprotkb": "Mediator of DNA damage checkpoint protein 1", "protein_names_refseq": "mediation of DNA damage checkpoint 1; mediator of DNA damage checkpoint protein 1 isoform a", "tax_id": 10090, "disease": "breast carcinoma (Disease Ontology:DOID:3459); lung carcinoma (Disease Ontology:DOID:3905); cervical cancer (Disease Ontology:DOID:4362); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:240087); (R-MMU-3108214); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15611643;16427009;17158742;17242355;19131326;19144319;21183079;21750661;23039116;23806337;25153642;25428506;28135057;30779550;31219806;36999590", "class_list": "", "function": "Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis. Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs., [UniProtKB, UniProtKB]; Identification and description of a functional homologue of human MDC1/ NFBD1; in response to ionizing radiation it forms foci that co-localize with the MRE11-RAD50-NBS1 (MRN) complex and factors such as gammaH2AX and 53BP1, [RefSeq, PubMed]; MDC1 knockdown affected the formation of telomere dysfunction-induced foci., [RefSeq, PubMed]; MDC1, as a signal amplifier of the ATM pathway, is vital in controlling proper DNA damage response and maintaining genomic stability., [RefSeq, PubMed]; Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes., [RefSeq, PubMed]; The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 7 divergent copies of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Mice with mutations in this gene exhibit growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivity. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 52, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q52KG1;Q5U4D3;Q6ZQH7", "ec_number_list": [], "go_molecular_function": "GO:0140463 chromatin-protein adaptor activity;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005925 focal adhesion;GO:0016604 nuclear body;GO:0035861 site of double-strand break", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0085020 protein K6-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q5PSV9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPV4-1", "uniprot_id": [ { "id": "GLOD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPV4", "type": "external" } ], "mass": 33317.0, "length": 298, "protein_name": "Glyoxalase domain-containing protein 4", "gene_name": "Glod4", "organism": "Mouse", "refseq_name": "glyoxalase domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_080305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080305", "type": "external" } ], "gene_names_uniprotkb": "Glod4", "gene_names_refseq": "1700082G03Rik; 2700085E05Rik; Glod4", "protein_names_uniprotkb": "Glyoxalase domain-containing protein 4", "protein_names_refseq": "glyoxalase domain-containing protein 4 isoform 1; glyoxalase domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67201)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;22645316;23806337;25153642;28135057;28528544", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUS8;Q9CY26;Q9D9F5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CPV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6J6-1", "uniprot_id": [ { "id": "NDUV2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6J6", "type": "external" } ], "mass": 27285.0, "length": 248, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial", "gene_name": "Ndufv2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001265344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265344", "type": "external" } ], "gene_names_uniprotkb": "Ndufv2", "gene_names_refseq": "2900010C23Rik; Ndufv2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; 7.1.1.2; NADH-ubiquinone oxidoreductase 24 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) flavoprotein 2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform 2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NADH-ubiquinone oxidoreductase 24 kDa subunit", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 7 (Disease Ontology:DOID:0112092); Parkinson's disease (Disease Ontology:DOID:14330); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:72900); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "21750661;23038253;23576753;29915388;34428180;34697471;36288343;37453647;37507081;38575788;39927985;40885482;6279147", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster., [UniProtKB, PubMed]; Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2., [RefSeq, PubMed]; The authors biochemically separate the NADH dehydrogenase module from complex I of bovine heart into subunit I, II and III fractions. Subunit II fraction, also known as the NADH dehydrogenase (ubiquinone) flavoprotein 2 protein, has a molecular weight of 24 000 Da and contains an iron-sulfur center., [RefSeq, PubMed]; The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFV2 can replace the endogenous protein in the holo-complex I protein and was also found in complex I subassemblies, suggesting that NDUFV2 may directly incorporate into the holo-enzyme and may also assemble into smaller complexes or in a monomer pool., [RefSeq, PubMed]; This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9L9;Q8BU07;Q8K2L0", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0007399 nervous system development;GO:0048738 cardiac muscle tissue development;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D6J6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1M4-1", "uniprot_id": [ { "id": "GLIS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1M4", "type": "external" } ], "mass": 84172.0, "length": 789, "protein_name": "Zinc finger protein GLIS1", "gene_name": "Glis1", "organism": "Mouse", "refseq_name": "zinc finger protein GLIS1", "refseq_ac": [ { "id": "NP_671754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671754", "type": "external" } ], "gene_names_uniprotkb": "Glis1; Gli5", "gene_names_refseq": "Gli5; Gli6; GliH1; Glis1", "protein_names_uniprotkb": "Zinc finger protein GLIS1; GLI-similar 1; Gli homologous protein 1; GliH1", "protein_names_refseq": "GLI-Kruppel family member GLI6; GLI-similar 1; Glis1 Kruppel-like zinc finger protein; gli homologous protein 1; zinc finger protein GLIS1; zinc finger transcription factor Gli5", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:230587)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12042312;12385751;21654807;21750661;30544251;32561646;32839595;33895473;34385434;35820727;36787938", "class_list": "", "function": "Acts both as a repressor and an ctivator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway., [RefSeq, PubMed]; GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Publication Status: Online-Only, [RefSeq, PubMed]; GliH1 has homology to the Gli zinc finger domain but is not required for mouse development, [RefSeq, PubMed]; Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Erratum:[Nat Metab. 2020 Oct;2(10):1179. doi: 10.1038/s42255-020-00308-0. PMID: 33033400], [RefSeq, PubMed]; Glis1 may play a critical role in the control of gene expression during specific stages of embryonic development., [RefSeq, PubMed]; Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation., [RefSeq, PubMed]; RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZF6;Q8R4Z3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0010454 negative regulation of cell fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K1M4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKZ7-1", "uniprot_id": [ { "id": "MOCS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RKZ7", "type": "external" } ], "mass": 69859.0, "length": 636, "protein_name": "Molybdenum cofactor biosynthesis protein 1", "gene_name": "Mocs1", "organism": "Mouse", "refseq_name": "molybdenum cofactor biosynthesis protein 1 isoform 1", "refseq_ac": [ { "id": "NP_064426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064426", "type": "external" } ], "gene_names_uniprotkb": "Mocs1", "gene_names_refseq": "3110045D15Rik; Mocs1", "protein_names_uniprotkb": "Molybdenum cofactor biosynthesis protein 1; MOCS1A; MOCS1B; Molybdenum cofactor biosynthesis protein A; Molybdenum cofactor biosynthesis protein C", "protein_names_refseq": "molybdenum cofactor biosynthesis protein 1 isoform 1; molybdenum cofactor biosynthesis protein 1; molybdenum cofactor synthesis-step 1 proteins A and B", "tax_id": 10090, "disease": "molybdenum cofactor deficiency type A (Disease Ontology:DOID:0111164)", "pathway": " (mmu:56738); (R-MMU-947581)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10917590;12471057;15862276;17236133;21750661;23576753;31219806;34428180", "class_list": "", "function": "Inactivity results in elevated sulfite and diminished sulfate levels throughout the organism, and various brain dysmorphisms., [RefSeq, PubMed]; Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVW8;B7ZWI5;Q8R058;Q9JL32;Q9JL33", "ec_number_list": [ { "id": "4.1.99.22", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.99.22", "type": "external" }, { "id": "4.6.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.17", "type": "external" } ], "go_molecular_function": "GO:0061798 GTP 3',8'-cyclase activity;GO:0061799 cyclic pyranopterin monophosphate synthase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5RKZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PV5-1", "uniprot_id": [ { "id": "BHE41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PV5", "type": "external" } ], "mass": 43946.0, "length": 410, "protein_name": "Class E basic helix-loop-helix protein 41", "gene_name": "Bhlhe41", "organism": "Mouse", "refseq_name": "class E basic helix-loop-helix protein 41 isoform 2", "refseq_ac": [ { "id": "NP_001258697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258697", "type": "external" } ], "gene_names_uniprotkb": "Bhlhe41; Bhlhb3; Dec2", "gene_names_refseq": "6430520M22Rik; Bhlhb2l; Bhlhb3; Bhlhe41; DEC2; Sharp1", "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 41; Class B basic helix-loop-helix protein 3; Differentially expressed in chondrocytes protein 2; bHLHb3; bHLHe41; mDEC2", "protein_names_refseq": "bHLH transcriptional factor Dec2; basic helix-loop-helix domain containing, class B3; class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41 isoform 2; class E basic helix-loop-helix protein 41; differentially expressed in chondrocytes protein 2", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lung adenocarcinoma (Disease Ontology:DOID:3910); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (mmu:79362)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11162494;12175508;12397359;12657651;14672706;15560782;18411297;19679812;19786558;21750661;24736997;25428506;30555544;37511489;38448474", "class_list": "", "function": "Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development. Review article Publication Status: Online-Only, [RefSeq, PubMed]; BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues. Publication Status: Online-Only, [RefSeq, PubMed]; Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family., [RefSeq, PubMed]; Functions as a transcriptional repressor of E box activity and Stra13 expression, [RefSeq, PubMed]; MSharp-1 may regulate the differentiation of several cell types during vertebrate development, [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99PV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05922-1", "uniprot_id": [ { "id": "DUSP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05922", "type": "external" } ], "mass": 34576.0, "length": 318, "protein_name": "Dual specificity protein phosphatase 2", "gene_name": "Dusp2", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 2", "refseq_ac": [ { "id": "NP_034220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034220", "type": "external" } ], "gene_names_uniprotkb": "Dusp2; Pac-1; Pac1", "gene_names_refseq": "Dusp2; PAC1", "protein_names_uniprotkb": "Dual specificity protein phosphatase 2; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase PAC-1", "protein_names_refseq": "dual specificity protein phosphatase 2; dual specificity protein phosphatase PAC-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13537); (R-MMU-112409); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16288922;29534174;31932812;34428180;37479052;37980508;7681221;7896276", "class_list": "", "function": "BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation, [RefSeq, PubMed]; Deletion of PAC1 enhances immune responses and reduces cancer susceptibility in mice. Through activation of EGR1, excessive reactive oxygen species in the tumor microenvironment induce expression of PAC1, which recruits the Mi-2beta nucleosome-remodeling and histone-deacetylase complex, eventually leading to chromatin remodeling of effector T cells., [RefSeq, PubMed]; Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:16288922). Can dephosphorylate MAPK1 (PubMed:16288922)., [UniProtKB, PubMed]; Interfering with Dusp2 alleviates high glucose-induced vascular endothelial cell dysfunction by promoting p38 MAPK pathway activation., [RefSeq, PubMed]; PAC1 deficiency reduces chondrogenesis in atherosclerotic lesions of hypercholesterolemic ApoE-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60640;Q80ZN1", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05922-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6S7F2-1", "uniprot_id": [ { "id": "E2F7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6S7F2", "type": "external" } ], "mass": 99535.0, "length": 904, "protein_name": "Transcription factor E2F7", "gene_name": "E2f7", "organism": "Mouse", "refseq_name": "transcription factor E2F7", "refseq_ac": [ { "id": "NP_848724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848724", "type": "external" } ], "gene_names_uniprotkb": "E2f7", "gene_names_refseq": "A630014C11Rik; D10Ertd739e; E2F-7; E2f7", "protein_names_uniprotkb": "Transcription factor E2F7; E2F-7", "protein_names_refseq": "transcription factor E2F7", "tax_id": 10090, "disease": "", "pathway": " (mmu:52679); (R-MMU-6804116)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12893818;18194653;21750661;22180533;22516201;22802529;22903062;23064264;23064266;31219806;36658310;37358838", "class_list": "", "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas., [RefSeq, PubMed]; E2F7, a novel E2F family member, can block the E2F-dependent activation of a subset of E2F target genes as well as mitigate cellular proliferation of mouse embryo fibroblasts, [RefSeq, PubMed]; Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55., [RefSeq, PubMed]; Results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWZ8;Q8BRE2;Q8BSQ3;Q8C9R3", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6S7F2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50153-1", "uniprot_id": [ { "id": "GBG4_MOUSE", "url": "https://www.uniprot.org/uniprot/P50153", "type": "external" } ], "mass": 8405.0, "length": 75, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4", "gene_name": "Gng4", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor", "refseq_ac": [ { "id": "NP_001289926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289926", "type": "external" } ], "gene_names_uniprotkb": "Gng4; Gngt4", "gene_names_refseq": "Gng4; Hg3c", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; heterotrimeric guanine nucleotide-binding protein 3c", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14706); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;23021213;24496152;7488078;9570961", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]; This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50153-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JT1-1", "uniprot_id": [ { "id": "GATB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JT1", "type": "external" } ], "mass": 62118.0, "length": 557, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "gene_name": "Gatb", "organism": "Mouse", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_659145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659145", "type": "external" } ], "gene_names_uniprotkb": "Gatb; Pet112l; Pet112", "gene_names_refseq": "9430026F02Rik; Gatb; Pet112l; Pet112", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; 6.3.5.-; Cytochrome c oxidase assembly factor PET112 homolog; Glu-AdT subunit B", "protein_names_refseq": "cytochrome c oxidase assembly factor PET112 homolog; cytochrome oxidase assembly factor PET112 homolog; glu-AdT subunit B; glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor; glutamyl-tRNA(Gln) amidotransferase, subunit B; probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 41 (Disease Ontology:DOID:0112119)", "pathway": " (mmu:229487)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23806337;25428506", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMU3;Q8BUY3", "ec_number_list": [ { "id": "6.3.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.-", "type": "external" }, { "id": "6.3.5.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.7", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99JT1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14152-1", "uniprot_id": [ { "id": "MDHC_MOUSE", "url": "https://www.uniprot.org/uniprot/P14152", "type": "external" } ], "mass": 36511.0, "length": 334, "protein_name": "Malate dehydrogenase, cytoplasmic", "gene_name": "Mdh1", "organism": "Mouse", "refseq_name": "malate dehydrogenase, peroxisomal isoform Mdh1x", "refseq_ac": [ { "id": "NP_001303604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303604", "type": "external" } ], "gene_names_uniprotkb": "Mdh1; Mor2", "gene_names_refseq": "B230377B03Rik; KAR; MDH-s; MDHA; Mdh1; Mor-2; Mor2", "protein_names_uniprotkb": "Malate dehydrogenase, cytoplasmic; 1.1.1.37; Aromatic alpha-keto acid reductase; Cytosolic malate dehydrogenase; KAR", "protein_names_refseq": "aromatic alpha-keto acid reductase; cytosolic malate dehydrogenase; malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal isoform Mdh1x; malate dehydrogenase, peroxisomal; malate dehydrogenase, soluble", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 88 (Disease Ontology:DOID:0112222)", "pathway": " (mmu:17449); (R-MMU-9856872)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;16139798;21183079;21750661;22645316;23576753;23806337;24129315;25428506;26495903;26740625;28011936;30084848;31219806;3172222;3312200;33725478;34428180;35879546;36288343;37453647;37507081;37828378;39927985", "class_list": "", "function": "Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1., [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. A pseudogene has been identified on chromosomes 12. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP22;Q80Y13;Q9DB45", "ec_number_list": [ { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0030060 L-malate dehydrogenase (NAD+) activity;GO:0016615 malate dehydrogenase activity;GO:0047995 (2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity;GO:0047860 diiodophenylpyruvate reductase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006094 gluconeogenesis;GO:0006107 oxaloacetate metabolic process;GO:0019674 NAD+ metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P14152-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VN4-1", "uniprot_id": [ { "id": "MIC25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VN4", "type": "external" } ], "mass": 29852.0, "length": 273, "protein_name": "MICOS complex subunit Mic25", "gene_name": "Chchd6", "organism": "Mouse", "refseq_name": "MICOS complex subunit Mic25 isoform 2", "refseq_ac": [ { "id": "NP_001161208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161208", "type": "external" } ], "gene_names_uniprotkb": "Chchd6; Mic25", "gene_names_refseq": "0710001P09Rik; 1700021B03Rik; Chchd6; Micos25", "protein_names_uniprotkb": "MICOS complex subunit Mic25; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6", "protein_names_refseq": "MICOS complex subunit Mic25 isoform 2; MICOS complex subunit Mic25; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial", "tax_id": 10090, "disease": "hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:66098)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;22645316;33300544;36104602;36288343", "class_list": "", "function": "A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease., [RefSeq, PubMed]; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNQ1;Q9D5I5;Q9DAM8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0061617 MICOS complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91VN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBD2-1", "uniprot_id": [ { "id": "MCM10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBD2", "type": "external" } ], "mass": 98406.0, "length": 885, "protein_name": "Protein MCM10 homolog", "gene_name": "Mcm10", "organism": "Mouse", "refseq_name": "protein MCM10 homolog", "refseq_ac": [ { "id": "NP_001292188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292188", "type": "external" } ], "gene_names_uniprotkb": "Mcm10", "gene_names_refseq": "2410041F14Rik; C330019M07Rik; Mcm10", "protein_names_uniprotkb": "Protein MCM10 homolog", "protein_names_refseq": "minichromosome maintenance deficient 10; protein MCM10 homolog", "tax_id": 10090, "disease": "immunodeficiency 80 (Disease Ontology:DOID:0061051)", "pathway": " (mmu:70024); (R-MMU-176187); (R-MMU-68962)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21183079;21693137;25428506;30084848;31219806", "class_list": "", "function": "Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (By similarity)., [UniProtKB, UniProtKB]; Genetic evidence for an essential and non-redundant physiological role of MCM10 during murine peri-implantation development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q505F3;Q8BMJ1;Q8BYA7", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0008283 cell population proliferation;GO:0006974 DNA damage response;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0VBD2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10470-1", "uniprot_id": [ { "id": "MGAT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q10470", "type": "external" } ], "mass": 62003.0, "length": 538, "protein_name": "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase", "gene_name": "Mgat3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mgat3", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; 2.4.1.144; GNT-III; GlcNAc-T III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-975574)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11986323;16537539;20805325;25592972;26467158;30084848;7590346;9061364", "class_list": "glycogene;glycosyltransferase", "function": "It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides (PubMed:11986323, PubMed:25592972). The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (By similarity). Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (By similarity). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (PubMed:25592972, PubMed:26467158). Adds bisecting GlcNAc residue to complex-type N-linked-glycans attached on fragment crystallizable (Fc) of IgGs. Readily converts fucosylated and non-fucosylated core glycoforms with terminal GlcNAcs on both antennae. Prior galactosylation of GlcNAc on the alpha(1->3) Man branch prevents N-glycan bisection, whereas galactosylation of GlcNAc on the alpha(1->6) Man branch is permissive., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70386", "ec_number_list": [ { "id": "2.4.1.144", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.144", "type": "external" } ], "go_molecular_function": "GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:1902966 positive regulation of protein localization to early endosome;GO:0050435 amyloid-beta metabolic process;GO:0050890 cognition;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 2382, "hit_score": 1.2, "record_id": "Q10470-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F2C3-1", "uniprot_id": [ { "id": "MEIKN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5F2C3", "type": "external" } ], "mass": 47423.0, "length": 434, "protein_name": "Meiosis-specific kinetochore protein", "gene_name": "Meikin", "organism": "Mouse", "refseq_name": "meiosis-specific kinetochore protein", "refseq_ac": [ { "id": "NP_083381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083381", "type": "external" } ], "gene_names_uniprotkb": "Meikin", "gene_names_refseq": "4930404A10Rik; Meikin", "protein_names_uniprotkb": "Meiosis-specific kinetochore protein", "protein_names_refseq": "meiosis-specific kinetochore protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74847)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25533956;34331869;39093409", "class_list": "", "function": "Integrative analysis indicates that the long-awaited key regulator of meiotic kinetochore function is Meikin, which is conserved from yeasts to humans Erratum:[Nature. 2018 Nov;563(7731):E23. doi: 10.1038/s41586-018-0530-3. PMID: 30275477], [RefSeq, PubMed]; Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis., [UniProtKB, PubMed]; MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte., [RefSeq, PubMed]; Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNB2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0007060 male meiosis chromosome segregation;GO:0010789 meiotic sister chromatid cohesion involved in meiosis I;GO:0016321 female meiosis chromosome segregation;GO:0051754 meiotic sister chromatid cohesion, centromeric", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5F2C3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FW52-3", "uniprot_id": [ { "id": "MLIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FW52", "type": "external" } ], "mass": 103448.0, "length": 967, "protein_name": "Muscular LMNA-interacting protein", "gene_name": "Mlip", "organism": "Mouse", "refseq_name": "muscular LMNA-interacting protein isoform 32", "refseq_ac": [ { "id": "NP_081426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081426", "type": "external" } ], "gene_names_uniprotkb": "Mlip; Cip", "gene_names_refseq": "2310046A06Rik; CIP; Mlip", "protein_names_uniprotkb": "Muscular LMNA-interacting protein; CIP; Cardiac Isl1-interacting protein; Muscular-enriched A-type laminin-interacting protein", "protein_names_refseq": "cardiac Isl1-interacting protein; muscular LMNA-interacting protein isoform 32; muscular-enriched A-type laminin-interacting protein", "tax_id": 10090, "disease": "myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 1 (Disease Ontology:DOID:0061183)", "pathway": " (mmu:69642)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21498514;22343712;26359501;26436652;30389785;32719146;33802236;34400329;36112854", "class_list": "", "function": "Cardiac CIP protein regulates dystrophic cardiomyopathy., [RefSeq, PubMed]; Deletion of the CIP-encoding gene accelerated progress from hypertrophy to heart failure in several cardiomyopathy models., [RefSeq, PubMed]; MLIP is expressed most highly in striated and smooth muscle, it is likely to contribute to the mesenchymal phenotypes of laminopathies., [RefSeq, PubMed]; Mlip tissue-specific expression and alternative splicing play a critical role in determining MLIP's functions in mice, [RefSeq, PubMed]; Mlip-deficient hearts showed an impaired capacity to adapt to stress (isoproterenol-induced hypertrophy), likely because of deregulated Akt/mTOR activity., [RefSeq, PubMed]; Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein., [RefSeq, PubMed]; Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (PubMed:33802236). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (PubMed:22343712, PubMed:26359501, PubMed:26436652). Binds chromatin (PubMed:33802236). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (PubMed:22343712). May also repress MYOCD transcriptional activity (PubMed:22343712)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Studies identify cardiac Isl1-interacting protein (CIP) as a novel regulator of cardiac hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZMP8;Q9D6X9;V9GWW6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0005521 lamin binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0042383 sarcolemma", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress;GO:0010614 negative regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5FW52-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D074-1", "uniprot_id": [ { "id": "MGRN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D074", "type": "external" } ], "mass": 58477.0, "length": 532, "protein_name": "E3 ubiquitin-protein ligase MGRN1", "gene_name": "Mgrn1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MGRN1 isoform 1", "refseq_ac": [ { "id": "NP_001239366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239366", "type": "external" } ], "gene_names_uniprotkb": "Mgrn1; Kiaa0544", "gene_names_refseq": "2610042J20Rik; Mgrn1; mKIAA0544; md; nc", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MGRN1; 2.3.2.27; Mahogunin RING finger protein 1; RING-type E3 ubiquitin transferase MGRN1", "protein_names_refseq": "E3 ubiquitin-protein ligase MGRN1 isoform 1; RING-type E3 ubiquitin transferase MGRN1; mahoganoid; mahogunin RING finger protein 1; probable E3 ubiquitin-protein ligase MGRN1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17237); (R-MMU-983168)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;12438443;12560552;15592455;17075880;17083490;17720281;18250455;19144319;19422019;19524515;19703557;21183079;22872234;25428506;26495903;28011936;28528544;28935714;29290584;33300544;34203471;34428180;34921635;35984892;36012221;37828378", "class_list": "", "function": "Distribution and Localization of Mahogunin Ring Finger 1 in the Mouse Central Nervous System. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Also acts as a negative regulator of hedgehog signaling (PubMed:29290584)., [UniProtKB, PubMed, PubMed, PubMed]; Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5V9;Q3UDA1;Q6ZQ97;Q8BZM9", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0008333 endosome to lysosome transport;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9D074-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWV4-1", "uniprot_id": [ { "id": "MLF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWV4", "type": "external" } ], "mass": 30432.0, "length": 267, "protein_name": "Myeloid leukemia factor 1", "gene_name": "Mlf1", "organism": "Mouse", "refseq_name": "myeloid leukemia factor 1 isoform b", "refseq_ac": [ { "id": "NP_034931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034931", "type": "external" } ], "gene_names_uniprotkb": "Mlf1; Hls7", "gene_names_refseq": "HLS7; Mlf1", "protein_names_uniprotkb": "Myeloid leukemia factor 1; Hematopoietic lineage switch 7; Myelodysplasia-myeloid leukemia factor 1", "protein_names_refseq": "hematopoietic lineage switch 7; myelodysplasia-myeloid leukemia factor 1; myeloid leukemia factor 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:17349)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10393836;10523300;12176995;15122318;17008314;19892989;21183079;21750661;27914912;28137643;34428180", "class_list": "", "function": "Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus., [UniProtKB, PubMed, PubMed]; The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70217", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:1901796 regulation of signal transduction by p53 class mediator;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QWV4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTU6-1", "uniprot_id": [ { "id": "MK09_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTU6", "type": "external" } ], "mass": 48189.0, "length": 423, "protein_name": "Mitogen-activated protein kinase 9", "gene_name": "Mapk9", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 9 isoform beta2", "refseq_ac": [ { "id": "NP_001157143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157143", "type": "external" } ], "gene_names_uniprotkb": "Mapk9; Jnk2; Prkm9", "gene_names_refseq": "JNK2; Mapk9; Prkm9; p54aSAPK", "protein_names_uniprotkb": "Mitogen-activated protein kinase 9; 2.7.11.24; MAP kinase 9; MAPK 9; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2", "protein_names_refseq": "JNK/SAPK alpha; Jun kinase; MAP kinase 9; MAPK 9; c-Jun N-terminal kinase 2; mitogen-activated protein kinase 9 isoform beta2; protein kinase, mitogen-activated 9; stress-activated protein kinase JNK2", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:26420); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450321); (R-MMU-450341)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10523642;10674476;10811224;11562351;16628014;16973441;18034455;21183079;21554942;22441692;27084103;29153991;39169203;9806643", "class_list": "", "function": "JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms. Erratum:[Sci Rep. 2025 Sep 18;15(1):32593. doi: 10.1038/s41598-025-17846-w. PMID: 40968147] Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:10811224, PubMed:11562351, PubMed:16973441, PubMed:21554942, PubMed:22441692, PubMed:29153991, PubMed:9806643). Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:10811224, PubMed:11562351, PubMed:16973441, PubMed:21554942, PubMed:22441692, PubMed:29153991, PubMed:9806643). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2 (By similarity). In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3 (By similarity). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1 (By similarity). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells (PubMed:10811224). Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels (PubMed:10811224). Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption (By similarity). When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway (By similarity). Also participates in neurite growth in spiral ganglion neurons (PubMed:21554942). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (PubMed:29153991). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCK9;Q5NCL5;Q8C097;Q8VDD2;Q9WTU4;Q9WTU5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007258 JUN phosphorylation;GO:0061833 protein localization to tricellular tight junction;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9WTU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61543-1", "uniprot_id": [ { "id": "GSLG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61543", "type": "external" } ], "mass": 133734.0, "length": 1175, "protein_name": "Golgi apparatus protein 1", "gene_name": "Glg1", "organism": "Mouse", "refseq_name": "Golgi apparatus protein 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033175", "type": "external" } ], "gene_names_uniprotkb": "Glg1; Esl1; Mg160; Selel", "gene_names_refseq": "CFR-1; CFR; ESL-1; Glg1; MG-160; MG160; Selel", "protein_names_uniprotkb": "Golgi apparatus protein 1; E-selectin ligand 1; ESL-1; Golgi sialoglycoprotein MG-160; Selel", "protein_names_refseq": "E-selectin ligand 1; Golgi apparatus protein 1 isoform 2 precursor; golgi sialoglycoprotein MG-160; selectin, endothelial cell, ligand", "tax_id": 10090, "disease": "", "pathway": " (mmu:20340); (R-MMU-202733)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10556428;19349973;19656770;21183079;21750661;26495903;26740625;26742601;27159043;28011936;30899004;32152506;33300544;37828378;39627609;7531823;9099943", "class_list": "", "function": "A cell-intrinsic mechanism whereby haematopoietic cells limit proliferation within the bone marrow is repressed by E-selectin ligand 1 (ESL-1). Publication Status: Online-Only, [RefSeq, PubMed]; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils)., [UniProtKB, PubMed]; Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ40", "ec_number_list": [], "go_molecular_function": "GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060349 bone morphogenesis;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032330 regulation of chondrocyte differentiation;GO:0010955 negative regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q61543-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64287-1", "uniprot_id": [ { "id": "IRF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64287", "type": "external" } ], "mass": 51577.0, "length": 450, "protein_name": "Interferon regulatory factor 4", "gene_name": "Irf4", "organism": "Mouse", "refseq_name": "interferon regulatory factor 4 isoform b", "refseq_ac": [ { "id": "NP_001334437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334437", "type": "external" } ], "gene_names_uniprotkb": "Irf4; Spip", "gene_names_refseq": "IRF-4; Irf4; LSIRF; NF-EM5; Spip", "protein_names_uniprotkb": "Interferon regulatory factor 4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; NF-EM5; PU.1 interaction partner; Transcriptional activator PIP", "protein_names_refseq": "PU.1 interaction partner; Sfpi1/PU.1 interaction partner; interferon regulatory factor 4 isoform b; lymphocyte-specific interferon regulatory factor; transcriptional activator PIP", "tax_id": 10090, "disease": "anaplastic large cell lymphoma (Disease Ontology:DOID:0050744); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); peripheral T-cell lymphoma (Disease Ontology:DOID:0050749); follicular lymphoma (Disease Ontology:DOID:0050873); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); immunodeficiency 131 (Disease Ontology:DOID:0061125); pigmentation disease (Disease Ontology:DOID:10123); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); middle cerebral artery infarction (Disease Ontology:DOID:3525); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:16364)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20697158;21750661;22983707;22992523;22992524;26098997;36662884;7541907;7797077", "class_list": "", "function": "Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60802", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64287-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09173-1", "uniprot_id": [ { "id": "HGD_MOUSE", "url": "https://www.uniprot.org/uniprot/O09173", "type": "external" } ], "mass": 49960.0, "length": 445, "protein_name": "Homogentisate 1,2-dioxygenase", "gene_name": "Hgd", "organism": "Mouse", "refseq_name": "homogentisate 1,2-dioxygenase", "refseq_ac": [ { "id": "NP_038575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038575", "type": "external" } ], "gene_names_uniprotkb": "Hgd; Aku; Hgo", "gene_names_refseq": "Hgd; Hgo; aku", "protein_names_uniprotkb": "Homogentisate 1,2-dioxygenase; 1.13.11.5; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase", "protein_names_refseq": "alkaptonuria; homogentisate 1,2-dioxygenase; homogentisate oxygenase; homogentisic acid oxidase; homogentisicase", "tax_id": 10090, "disease": "alkaptonuria (Disease Ontology:DOID:9270)", "pathway": " (mmu:15233); (R-MMU-8963684)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23806337;31600782;34428180;37453647;7705358;9069115", "class_list": "", "function": "Catalyzes the conversion of homogentisate to maleylacetoacetate., [UniProtKB, PubMed]; HGD knockout mouse exhibits the characteristic traits of alkaptonuria (AK)U. Both adult and embryo HGD expression has been localized to the liver and kidney only. More importantly, the conditional Hgd tm1d MxCre model has highlighted the importance of liver HGD expression in limiting the pathological effects of the HGA pool despite apparent reabsorption of homogentisic acid in the kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPP2", "ec_number_list": [ { "id": "1.13.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.5", "type": "external" } ], "go_molecular_function": "GO:0004411 homogentisate 1,2-dioxygenase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O09173-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28359-1", "uniprot_id": [ { "id": "HXD10_MOUSE", "url": "https://www.uniprot.org/uniprot/P28359", "type": "external" } ], "mass": 38328.0, "length": 340, "protein_name": "Homeobox protein Hox-D10", "gene_name": "Hoxd10", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D10", "refseq_ac": [ { "id": "NP_038582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038582", "type": "external" } ], "gene_names_uniprotkb": "Hoxd10; Hox-4.5; Hoxd-10", "gene_names_refseq": "Hox-4.5; Hox-5.3; Hoxd10", "protein_names_uniprotkb": "Homeobox protein Hox-D10; Homeobox protein Hox-4.5; Homeobox protein Hox-5.3", "protein_names_refseq": "homeo box D10; homeobox protein Hox-4.5; homeobox protein Hox-5.3; homeobox protein Hox-D10", "tax_id": 10090, "disease": "congenital vertical talus (Disease Ontology:DOID:0111568)", "pathway": " (mmu:15430)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1348690;21183079;2569969;2569970", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WU9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28359-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61316-1", "uniprot_id": [ { "id": "HSP74_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61316", "type": "external" } ], "mass": 94133.0, "length": 841, "protein_name": "Heat shock 70 kDa protein 4", "gene_name": "Hspa4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hspa4; Apg2; Hsp110; Hsph2", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock 70 kDa protein 4; Heat shock 70-related protein APG-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); Chagas disease (Disease Ontology:DOID:12140); Parkinson's disease (Disease Ontology:DOID:14330); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-MMU-3371453)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17242355;17947660;18034455;21183079;23806337;34428180;36288343;39627609;39927985;9161406", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0070062 extracellular exosome", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0051402 neuron apoptotic process;GO:0001933 negative regulation of protein phosphorylation;GO:0006457 protein folding;GO:1903978 regulation of microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61316-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D023-1", "uniprot_id": [ { "id": "MPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D023", "type": "external" } ], "mass": 14286.0, "length": 127, "protein_name": "Mitochondrial pyruvate carrier 2", "gene_name": "Mpc2", "organism": "Mouse", "refseq_name": "mitochondrial pyruvate carrier 2", "refseq_ac": [ { "id": "NP_081706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081706", "type": "external" } ], "gene_names_uniprotkb": "Mpc2; Brp44", "gene_names_refseq": "0610006C01Rik; 2010002I07Rik; 2610205H19Rik; Brp44; ESTM43; Mpc2", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 2; Brain protein 44", "protein_names_refseq": "brain protein 44; mitochondrial pyruvate carrier 2", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:70456)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22628554;23576753;31219806;33300544;34428180;36210013", "class_list": "", "function": "Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628554). Plays an essential role in cellular metabolism (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UA44", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0098800 inner mitochondrial membrane protein complex;GO:7770001 mitochondrial pyruvate carrier complex", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D023-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62774-1", "uniprot_id": [ { "id": "MTPN_MOUSE", "url": "https://www.uniprot.org/uniprot/P62774", "type": "external" } ], "mass": 12861.0, "length": 118, "protein_name": "Myotrophin", "gene_name": "Mtpn", "organism": "Mouse", "refseq_name": "myotrophin", "refseq_ac": [ { "id": "NP_032124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032124", "type": "external" } ], "gene_names_uniprotkb": "Mtpn; Gcdp", "gene_names_refseq": "5033418D15Rik; Gcdp; Mtpn; V1", "protein_names_uniprotkb": "Myotrophin; Granule cell differentiation protein; Protein V-1", "protein_names_refseq": "granule cell differentiation protein; myotrophin; protein V-1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:14489)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20224724;20538588;21750661;23806337;24778263;25153642;26495903;26740625;7607560;8428777", "class_list": "", "function": "MiR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by repressing myotrophin (V1) protein expression. Publication Status: Online-Only, [RefSeq, PubMed]; Our data argue that a large pool of freely diffusing, inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex exchange, the formation of weak-capping complexes (CP:CARMIL) at the plasma membrane of protruding edges., [RefSeq, PubMed]; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer., [UniProtKB, PubMed]; Rat neonatal cardiac myocytes incubated with myotrophin showed an increase in c-myc, c-fos, and c-jun RNA levels and an increase in connexin 43, atrial natriuretic factor, skeletal alpha-actin, and total myosin transcript levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P80144;Q543M6;Q9DCN8", "ec_number_list": [], "go_molecular_function": "GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:2000812 regulation of barbed-end actin filament capping;GO:0030307 positive regulation of cell growth;GO:0051247 positive regulation of protein metabolic process;GO:0010613 positive regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62774-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AT66-1", "uniprot_id": [ { "id": "MOT7_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AT66", "type": "external" } ], "mass": 66236.0, "length": 607, "protein_name": "Monocarboxylate transporter 7", "gene_name": "Slc16a6", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 7 isoform b", "refseq_ac": [ { "id": "NP_598799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598799", "type": "external" } ], "gene_names_uniprotkb": "Slc16a6; Mct7", "gene_names_refseq": "ESTM12; MCT 6; MCT 7; MCT6; Slc16a6", "protein_names_uniprotkb": "Monocarboxylate transporter 7; MCT 6; MCT 7; Monocarboxylate transporter 6; Solute carrier family 16 member 6", "protein_names_refseq": "monocarboxylate transporter 6; monocarboxylate transporter 7 isoform b; monocarboxylate transporter 7; solute carrier family 16 member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:104681)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;21750661;26495903;30084848;31436537;34428180;35820727", "class_list": "", "function": "Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations., [UniProtKB, UniProtKB]; Results from the knockout (KO) mouse model of Mct6 deficiency support the importance of MCT6 in regulating a variety of glucose and lipid metabolic pathways, which may indicate its significance in metabolic diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z3P6;E9Q5J8;Q3TCY8;Q8C086;Q91W47", "ec_number_list": [], "go_molecular_function": "GO:0005368 taurine transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1AT66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28667-1", "uniprot_id": [ { "id": "MRP_MOUSE", "url": "https://www.uniprot.org/uniprot/P28667", "type": "external" } ], "mass": 20165.0, "length": 200, "protein_name": "MARCKS-related protein", "gene_name": "Marcksl1", "organism": "Mouse", "refseq_name": "MARCKS-related protein", "refseq_ac": [ { "id": "NP_034937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034937", "type": "external" } ], "gene_names_uniprotkb": "Marcksl1; Mlp; Mrp", "gene_names_refseq": "D4Bc1; F52; MacMARCKS; Macs2; Macs3; Marcksl1; Mlp; Mrp", "protein_names_uniprotkb": "MARCKS-related protein; Brain protein F52; MARCKS-like protein 1; Mac-MARCKS; MacMARCKS; Macrophage myristoylated alanine-rich C kinase substrate", "protein_names_refseq": "MARCKS-like protein 1; MARCKS-related protein; brain protein F52; mac-MARCKS; macrophage myristoylated alanine-rich C kinase substrate", "tax_id": 10090, "disease": "", "pathway": " (mmu:17357)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "1516135;15345747;1618855;1864362;19144319;21183079;22751924;26495903;29580842;32639874;35820727;8406449;9598313;9819217", "class_list": "", "function": "Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (PubMed:22751924). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (PubMed:22751924). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable)., [UniProtKB, PubMed, PubMed]; MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors., [RefSeq, PubMed]; Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEZ4;Q91W07", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0008284 positive regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P28667-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54276-1", "uniprot_id": [ { "id": "MSH6_MOUSE", "url": "https://www.uniprot.org/uniprot/P54276", "type": "external" } ], "mass": 151084.0, "length": 1358, "protein_name": "DNA mismatch repair protein Msh6", "gene_name": "Msh6", "organism": "Mouse", "refseq_name": "DNA mismatch repair protein Msh6", "refseq_ac": [ { "id": "NP_034960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034960", "type": "external" } ], "gene_names_uniprotkb": "Msh6; Gtmbp", "gene_names_refseq": "GTBP; Gtmbp; Msh6", "protein_names_uniprotkb": "DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; MutS protein homolog 6; MutS-alpha 160 kDa subunit; p160", "protein_names_refseq": "DNA mismatch repair protein Msh6; g/T mismatch-binding protein; mutS protein homolog 6; mutS-alpha 160 kDa subunit; p160", "tax_id": 10090, "disease": "hereditary nonpolyposis colorectal cancer type 5 (Disease Ontology:DOID:0070272); colorectal carcinoma (Disease Ontology:DOID:0080199); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); Lynch syndrome (Disease Ontology:DOID:3883); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:17688); (R-MMU-5358565)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;25605945;29125738;30084848;31219806;33181035;34418053;34428180;36210013;39627609;8812455;9390556", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction (By similarity)., [UniProtKB, UniProtKB]; MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 11, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O54710;Q6GTK8", "ec_number_list": [], "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0032142 single guanine insertion binding;GO:0032143 single thymine insertion binding;GO:0000287 magnesium ion binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0006298 mismatch repair;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P54276-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFY8-1", "uniprot_id": [ { "id": "TM10C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFY8", "type": "external" } ], "mass": 48386.0, "length": 414, "protein_name": "tRNA methyltransferase 10 homolog C", "gene_name": "Trmt10c", "organism": "Mouse", "refseq_name": "tRNA methyltransferase 10 homolog C precursor", "refseq_ac": [ { "id": "NP_083368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083368", "type": "external" } ], "gene_names_uniprotkb": "Trmt10c; Mrpp1; Rg9mtd1", "gene_names_refseq": "1300018J16Rik; D16Ertd454e; Rg9mtd1; Rnmtd1; Trmt10c", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog C; 2.1.1.-; 2.1.1.218; 2.1.1.221; Mitochondrial RNase P protein 1; Mitochondrial ribonuclease P protein 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; mitochondrial RNase P protein 1; mitochondrial ribonuclease P protein 1; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase; tRNA methyltransferase 10 homolog C precursor; tRNA methyltransferase 10 homolog C", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 30 (Disease Ontology:DOID:0111471)", "pathway": " (mmu:52575)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16452087;17242355;21183079;37507081", "class_list": "", "function": "Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R588;Q9DBC1", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0000964 mitochondrial RNA 5'-end processing;GO:0006397 mRNA processing;GO:0070131 positive regulation of mitochondrial translation;GO:0042780 tRNA 3'-end processing;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UFY8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61884-1", "uniprot_id": [ { "id": "MNS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61884", "type": "external" } ], "mass": 60236.0, "length": 491, "protein_name": "Meiosis-specific nuclear structural protein 1", "gene_name": "Mns1", "organism": "Mouse", "refseq_name": "meiosis-specific nuclear structural protein 1 isoform 1", "refseq_ac": [ { "id": "NP_032639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032639", "type": "external" } ], "gene_names_uniprotkb": "Mns1", "gene_names_refseq": "Mns1", "protein_names_uniprotkb": "Meiosis-specific nuclear structural protein 1", "protein_names_refseq": "meiosis-specific nuclear structural protein 1 isoform 1", "tax_id": 10090, "disease": "visceral heterotaxy 9 (Disease Ontology:DOID:0051023)", "pathway": " (mmu:17427)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "18299400;19144319;21750661;21952136;22396656;25428506;25605945;30084848;30129265;30148830;34231842;34428180;37198331;37295417;37865089;37989994;8032679", "class_list": "", "function": "BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (PubMed:22396656). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Prenatal alcohol exposure Mns1(-/-) fetuses with severe eye defects also presented with craniofacial dysmorphologies characteristic of fetal alcohol syndrome and midline tissue loss in the brain, palate, and nasal septum, [RefSeq, PubMed]; These results demonstrate that MNS1 is essential for spermiogenesis, the assembly of sperm flagella, and motile ciliary functions. GeneRIF: MNS1 is an integral component of sperm flagella. Mice lacking MNS1 exhibit male sterility as evidenced by abnormal assembly of flagella. MNS1-deficient mice also display defects in left-right asymmetry patterning of internal organs and hydrocephalus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0070986 left/right axis specification;GO:0051321 meiotic cell cycle;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q61884-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLC3-1", "uniprot_id": [ { "id": "MSRB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLC3", "type": "external" } ], "mass": 12788.0, "length": 116, "protein_name": "Methionine-R-sulfoxide reductase B1", "gene_name": "Msrb1", "organism": "Mouse", "refseq_name": "methionine-R-sulfoxide reductase B1", "refseq_ac": [ { "id": "NP_001333597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333597", "type": "external" } ], "gene_names_uniprotkb": "Msrb1; Sepr; Sepx1", "gene_names_refseq": "D17Wsu82e; Msrb1; SELX; SelR; Sepr; Sepx1", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B1; 1.8.4.12; 1.8.4.14; MsrB1; SelR; SelX; Selenoprotein R; Selenoprotein X", "protein_names_refseq": "methionine-R-sulfoxide reductase B1; selenoprotein R; selenoprotein X 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27361); (R-MMU-5676934)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10567350;11929995;14699060;19636847;20605785;20634897;23911929;31219806;31672630;36351405", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine (PubMed:11929995, PubMed:14699060, PubMed:20605785, PubMed:23911929). While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue (PubMed:14699060, PubMed:20605785). Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization (PubMed:23911929). Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (PubMed:23911929)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation., [RefSeq, PubMed]; Study characterized unexpected diversity of protein and mRNA forms of mammalian selenoprotein MsrB1. Publication Status: Online-Only, [RefSeq, PubMed]; The chemical shift index for MsrB1 indicates that the beta-sheets are the main element for the protein secondary structure., [RefSeq, PubMed]; The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2016]., [RefSeq]; These results suggest that MsrB1 is essential for mice spatial learning and LTP/LTD induction, and the MsrB1 related redox homeostasis may be involved in regulating the phosphorylation of CaMKIIs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545U8", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045087 innate immune response;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JLC3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88322-1", "uniprot_id": [ { "id": "NID2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88322", "type": "external" } ], "mass": 153913.0, "length": 1403, "protein_name": "Nidogen-2", "gene_name": "Nid2", "organism": "Mouse", "refseq_name": "nidogen-2 precursor", "refseq_ac": [ { "id": "NP_032721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032721", "type": "external" } ], "gene_names_uniprotkb": "Nid2", "gene_names_refseq": "Ly111; NID-2; Nid2; entactin-2; nidogen-2", "protein_names_uniprotkb": "Nidogen-2; Entactin-2; NID-2", "protein_names_refseq": "entactin 2; nidogen-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18074); (R-MMU-3000157)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10022829;17324935;19349973;21750661;24129315;27802388;34428180;36354004;9633511", "class_list": "", "function": "Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions., [UniProtKB, UniProtKB, UniProtKB]; Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQF0", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88322-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPP6-1", "uniprot_id": [ { "id": "NDUA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPP6", "type": "external" } ], "mass": 13360.0, "length": 116, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "gene_name": "Ndufa5", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1", "refseq_ac": [ { "id": "NP_080890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080890", "type": "external" } ], "gene_names_uniprotkb": "Ndufa5", "gene_names_refseq": "2900002J19Rik; CI-13kD-B; Ndufa5", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; CI-13kD-B; Complex I subunit B13; Complex I-13kD-B; NADH-ubiquinone oxidoreductase 13 kDa-B subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; NADH-ubiquinone oxidoreductase 13 kDa-B subunit; complex I subunit B13; complex I-13kD-B", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:68202); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9013408)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "16329995;16452087;21750661;23576753;23806337;24154540;30324697;34428180;36288343;37453647;37507081;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; At the age of 11 months, mice with a central nervous system knockout of Ndufa5 (Ndufa5 CNS-KO) showed lethargy and loss of motor skills. In these mice cortices, the levels of NDUFA5 protein were reduced to 25% of controls. Fully assembled complex I (CI) levels were also greatly reduced in cortex and CI activity in homogenates was reduced to 60% of controls., [RefSeq, PubMed]; The real-time RT-PCR analysis revealed that the expressions of the NDUFA5 mRNA, but not the ZNF9 mRNA level, were significantly up-regulated in all the tested cell lines derived from HPV-positive cervical cancer, HeLa, SW576, and CaSKi., [RefSeq, PubMed]; Through bioinformatics prediction, we found miR-33a directly targeted on the 3'-UTR of NDUFA5. Dual-luciferase reporter analysis further confirmed the direct suppression of miR-33a on NDUFA5 expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY90;Q9D2P2;Q9D703;Q9D739", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0032991 protein-containing complex;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CPP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2U2-1", "uniprot_id": [ { "id": "RMP64_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2U2", "type": "external" } ], "mass": 63394.0, "length": 564, "protein_name": "Nucleolus and neural progenitor protein", "gene_name": "Nepro; Rmp64", "organism": "Mouse", "refseq_name": "nucleolus and neural progenitor protein isoform 1", "refseq_ac": [ { "id": "NP_666084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666084", "type": "external" } ], "gene_names_uniprotkb": "Nepro; Rmp64; Nepro", "gene_names_refseq": "Nepro; Rmp64", "protein_names_uniprotkb": "Nucleolus and neural progenitor protein; Neural progenitor protein", "protein_names_refseq": "neural progenitor protein; nucleolus and neural progenitor protein isoform 1; protein nepro", "tax_id": 10090, "disease": "anauxetic dysplasia 3 (Disease Ontology:DOID:0080963)", "pathway": " (mmu:212547)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19906856;21750661;25605945;26178919;31219806", "class_list": "", "function": "Specific component of the MRP ribonucleoprotein endoribonuclease, Rnase/Mrp complex, a ribonucleoprotein complex involved in pre-rRNA processing (By similarity). May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development (PubMed:19906856, PubMed:26178919)., [UniProtKB, PubMed, PubMed, UniProtKB]; The Nepro is a nucleolus-associated protein, and its loss leads to the apoptosis before blastocyst formation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006396 RNA processing;GO:0045665 negative regulation of neuron differentiation;GO:0045747 positive regulation of Notch signaling pathway;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R2U2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88942-1", "uniprot_id": [ { "id": "NFAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88942", "type": "external" } ], "mass": 77833.0, "length": 717, "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 1", "gene_name": "Nfatc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nfatc1; Nfat2; Nfatc", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NF-ATc; NFAT transcription complex cytosolic component; NFATc1; NFATc", "protein_names_refseq": "", "tax_id": 10090, "disease": "ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); aortic valve stenosis (Disease Ontology:DOID:1712); kidney disease (Disease Ontology:DOID:557); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (R-MMU-2025928); (R-MMU-2871809); (R-MMU-4086398); (R-MMU-5607763)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10072529;16968888;17198697;17579027;19626032;21183079;21435446;21514407;23478294;23990468;24039232;24970700;25428506;26644563;28341745;32741026;34428180;34445596;9388475", "class_list": "", "function": "Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription (PubMed:9388475). Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (By similarity). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (PubMed:23990468, PubMed:26644563)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70345", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0003170 heart valve development;GO:2000647 negative regulation of stem cell proliferation;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O88942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70441-1", "uniprot_id": [ { "id": "NHRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70441", "type": "external" } ], "mass": 38600.0, "length": 355, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "gene_name": "Nherf1", "organism": "Mouse", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "refseq_ac": [ { "id": "NP_036160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036160", "type": "external" } ], "gene_names_uniprotkb": "Nherf1; Nherf; Slc9a3r1", "gene_names_refseq": "EBP-50; NHE-RF; NHERF-1; Nherf1; Slc9a3r1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1; EBP50; Ezrin-radixin-moesin-binding phosphoprotein 50; NHERF-1; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1", "protein_names_refseq": "EBP50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; ezrin-radixin-moesin-binding phosphoprotein 50; regulatory cofactor of Na(+)/H(+) exchanger; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); malignant renovascular hypertension (Disease Ontology:DOID:13730)", "pathway": " (mmu:26941)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10500246;11777944;14531806;15378723;15466885;17242355;17311105;18630941;20200151;21183079;21976599;25605945;26495903;31219806;33952618;35820727;37453647;40684658;9560162", "class_list": "", "function": "Na(+)/H(+) Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite-Induced Asthma., [RefSeq, PubMed]; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling (By similarity). May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity). Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYD8", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0031698 beta-2 adrenergic receptor binding;GO:0060090 molecular adaptor activity;GO:0050780 dopamine receptor binding;GO:0031800 type 3 metabotropic glutamate receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0030033 microvillus assembly;GO:0003096 renal sodium ion transport;GO:0034635 glutathione transport;GO:0097291 renal phosphate ion absorption", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P70441-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60591-3", "uniprot_id": [ { "id": "NFAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60591", "type": "external" } ], "mass": 100020.0, "length": 927, "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 2", "gene_name": "Nfatc2", "organism": "Mouse", "refseq_name": "nuclear factor of activated T-cells, cytoplasmic 2 isoform a", "refseq_ac": [ { "id": "NP_035029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035029", "type": "external" } ], "gene_names_uniprotkb": "Nfatc2; Nfat1; Nfatp", "gene_names_refseq": "NF-ATc2; NF-ATp; NFAT1-D; NFAT1; Nfatc2; Nfatp", "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 2; NF-ATc2; NF-ATp; NFAT pre-existing subunit; NFATc2; T-cell transcription factor NFAT1", "protein_names_refseq": "NFAT pre-existing subunit; T-cell transcription factor NFAT1; nuclear factor of activated T-cells, cytoplasmic 2 isoform a; nuclear factor of activated T-cells, cytoplasmic 2", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:18019); (R-MMU-2025928); (R-MMU-2871809); (R-MMU-5607763)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10089876;10620601;11030334;11278367;17198697;17579027;18675896;21183079;23616576;24970700;25428506;28424240;32415068;33941685;34203471;36852467;37553428;37904191;37933452;7876165;8235597;8668213;8943202;9660947", "class_list": "", "function": "Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx., [RefSeq, PubMed]; Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation., [RefSeq, PubMed]; NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (By similarity). Is involved in the negative regulation of chondrogenesis (PubMed:10620601). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2APK2;A2APK3;A2AQC5;A2AQC6;A2AQC7;B5B2Q3;Q60984;Q60985;Q91Y65", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0014904 myotube cell development;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q60591-3", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60795-1", "uniprot_id": [ { "id": "NF2L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60795", "type": "external" } ], "mass": 66901.0, "length": 597, "protein_name": "Nuclear factor erythroid 2-related factor 2", "gene_name": "Nfe2l2", "organism": "Mouse", "refseq_name": "nuclear factor erythroid 2-related factor 2 isoform 1", "refseq_ac": [ { "id": "NP_035032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035032", "type": "external" } ], "gene_names_uniprotkb": "Nfe2l2; Nrf2", "gene_names_refseq": "Nfe2l2; Nrf2", "protein_names_uniprotkb": "Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor, erythroid derived 2, like 2", "protein_names_refseq": "NF-E2-related factor 2; NFE2-related factor 2; nuclear factor erythroid 2-related factor 2 isoform 1; nuclear factor erythroid 2-related factor 2", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); extrahepatic cholestasis (Disease Ontology:DOID:13619); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); tuberculosis (Disease Ontology:DOID:399); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); visceral leishmaniasis (Disease Ontology:DOID:9146); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18024); (R-MMU-8951664); (R-MMU-9755511); (R-MMU-9759194); (R-MMU-9762114)", "pathway_count": 5, "publication_count": 62, "publication_id_list": "11248092;11583586;12032331;12968018;14517290;14517554;14978030;15282312;15367669;15581590;16507366;16581765;16585964;16790436;17920186;20173742;20421418;20484733;20498371;23661004;24967692;25428506;25582778;25605945;26845617;27151674;27161318;27211851;27802388;28257879;28373747;28842501;29353218;30084848;30282635;30685263;31219806;31281590;31398338;31945188;32210977;32259797;32602850;32630085;33136552;33241629;33466349;33532181;33671212;33875681;34092244;34428180;35820727;36210013;37828378;39901237;41372976;41518202;7726861;8943040;9240432;9887101", "class_list": "", "function": "This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:12032331, PubMed:14517290, PubMed:14517554, PubMed:31398338, PubMed:9240432, PubMed:9887101). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:14517290, PubMed:15282312, PubMed:15367669, PubMed:15581590). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:12032331). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20173742, PubMed:20421418). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (PubMed:14517290, PubMed:14978030). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). Also plays an important role in the regulation of the innate immune response. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF signaling (PubMed:16585964). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (PubMed:27211851). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the Nrf2-binding motif and reactive oxygen species level (PubMed:27211851). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 5, "reported_glycation": 4, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQK0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0008134 transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0046223 aflatoxin catabolic process;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:1903788 positive regulation of glutathione biosynthetic process;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "Q60795-1", "record_type": "protein", "filter_code": "0000000.0110111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61043-3", "uniprot_id": [ { "id": "NIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61043", "type": "external" } ], "mass": 243718.0, "length": 2113, "protein_name": "Ninein", "gene_name": "Nin", "organism": "Mouse", "refseq_name": "ninein isoform 2", "refseq_ac": [ { "id": "NP_001273008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273008", "type": "external" } ], "gene_names_uniprotkb": "Nin; Kiaa1565", "gene_names_refseq": "3110068G20Rik; Nin; mKIAA1565", "protein_names_uniprotkb": "Ninein", "protein_names_refseq": "ninein isoform 2", "tax_id": 10090, "disease": "Seckel syndrome 7 (Disease Ontology:DOID:0070011)", "pathway": " (mmu:18080)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10934040;15784680;17227889;21183079;22299025;27565344;31219806;34428180;38836552;8834802", "class_list": "", "function": "Centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:10934040, PubMed:15784680). May also act as a centrosome maturation factor (By similarity). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15784680). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (By similarity). Required for centriole organization and microtubule anchoring at the mother centriole (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of ninein interferes with osteoclast formation and causes premature ossification. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1Y7VJL5;B2RQ73;B7ZMZ9;E9Q488;E9Q4S3;Q674R4;Q6ZPM7", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0090222 centrosome-templated microtubule nucleation;GO:0045666 positive regulation of neuron differentiation;GO:0048668 collateral sprouting;GO:0008104 intracellular protein localization;GO:0050772 positive regulation of axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61043-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAF4-1", "uniprot_id": [ { "id": "NHSL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAF4", "type": "external" } ], "mass": 169419.0, "length": 1587, "protein_name": "NHS-like protein 1", "gene_name": "Nhsl1", "organism": "Mouse", "refseq_name": "NHS-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001157064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157064", "type": "external" } ], "gene_names_uniprotkb": "Nhsl1; Kiaa1357", "gene_names_refseq": "5730409E15Rik; A630035H13Rik; A730096F01; D10Bwg0940e; Nhsl1; mKIAA1357", "protein_names_uniprotkb": "NHS-like protein 1", "protein_names_refseq": "NHS-like protein 1 isoform 2; NHS-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215819)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;22645316", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTY4;Q6P6Y7;Q8C8Z7;Q8K0R2;Q91YY6;Q9CYM2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CAF4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCN2-1", "uniprot_id": [ { "id": "NB5R3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCN2", "type": "external" } ], "mass": 34128.0, "length": 301, "protein_name": "NADH-cytochrome b5 reductase 3", "gene_name": "Cyb5r3", "organism": "Mouse", "refseq_name": "NADH-cytochrome b5 reductase 3", "refseq_ac": [ { "id": "NP_084063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084063", "type": "external" } ], "gene_names_uniprotkb": "Cyb5r3; Dia1", "gene_names_refseq": "0610016L08Rik; 2500002N19Rik; B5R; Cyb5r3; Dia-1; Dia1; WU:Cyb5r3", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 3; 1.6.2.2; B5R; Cytochrome b5 reductase; Diaphorase-1", "protein_names_refseq": "NADH-cytochrome b5 reductase 3; diaphorase 1 (NADH)", "tax_id": 10090, "disease": "estrogen-receptor negative breast cancer (Disease Ontology:DOID:0060076); methemoglobinemia (Disease Ontology:DOID:10783); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:109754); (R-MMU-196836); (R-MMU-211945); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "11471062;16916647;18250455;21750661;23576753;23806337;27802388;28011936;30084848;30779550;31296841;34428180;35984892;37453647;37828378;38253797;38335173;38830896;39069267", "class_list": "glycogene", "function": "Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor. Publication Status: Online-Only, [RefSeq, PubMed]; CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1alpha-JNK pathways., [RefSeq, PubMed]; CYB5R3 overexpression exhibits sexual dimorphism: Mitochondrial and metabolic adaptations in transgenic female mice during calorie restriction., [RefSeq, PubMed]; Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cyb5r3 activation rescues secondary failure to sulfonylurea but not beta-cell dedifferentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016208 AMP binding;GO:0043531 ADP binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9DCN2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMH7-1", "uniprot_id": [ { "id": "NEUR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMH7", "type": "external" } ], "mass": 46846.0, "length": 418, "protein_name": "Sialidase-3", "gene_name": "Neu3", "organism": "Mouse", "refseq_name": "sialidase-3", "refseq_ac": [ { "id": "NP_057929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057929", "type": "external" } ], "gene_names_uniprotkb": "Neu3", "gene_names_refseq": "Neu3", "protein_names_uniprotkb": "Sialidase-3; 3.2.1.18; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; Neuraminidase 3", "protein_names_refseq": "N-acetyl-alpha-neuraminidase 3; Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3); ganglioside sialidase; membrane sialidase; sialidase-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:50877); (R-MMU-4085001); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10713120;11696012;12730204;14970224;17708748;21183079;21750661;30779550;31219806;37871851;38272667", "class_list": "glycogene;glycosylhydrolase", "function": "EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3. Publication Status: Online-Only, [RefSeq, PubMed]; Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:10713120, PubMed:11696012, PubMed:14970224, PubMed:17708748). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; MmNEU3 is able to hydrolyze ganglioside substrates in intact living cells at a neutral pH, mainly through cell-to-cell interactions, [RefSeq, PubMed]; NEU3 participates in the control of insulin signaling via modulation of gangliosides and interaction with Grb2, [RefSeq, PubMed]; Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 50, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" } ], "go_molecular_function": "GO:0016997 alpha-sialidase activity;GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0005975 carbohydrate metabolic process;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway;GO:0009313 oligosaccharide catabolic process;GO:1900186 negative regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JMH7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000001.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PY46-1", "uniprot_id": [ { "id": "IF140_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PY46", "type": "external" } ], "mass": 165875.0, "length": 1464, "protein_name": "Intraflagellar transport protein 140 homolog", "gene_name": "Ift140", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 140 homolog isoform 1", "refseq_ac": [ { "id": "NP_598887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598887", "type": "external" } ], "gene_names_uniprotkb": "Ift140; WDTC2", "gene_names_refseq": "Ift140; Tce5; Wdtc2; mKIAA0590", "protein_names_uniprotkb": "Intraflagellar transport protein 140 homolog; WD and tetratricopeptide repeats protein 2", "protein_names_refseq": "T-complex expressed gene 5; WD and tetratricopeptide repeats 2; WD and tetratricopeptide repeats protein 2; intraflagellar transport 140 homolog; intraflagellar transport protein 140 homolog isoform 1; intraflagellar transport protein 140 homolog", "tax_id": 10090, "disease": "retinitis pigmentosa 80 (Disease Ontology:DOID:0061111); asphyxiating thoracic dystrophy 1 (Disease Ontology:DOID:0110085); short-rib thoracic dysplasia 9 with or without polydactyly (Disease Ontology:DOID:0110097)", "pathway": " (mmu:106633); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22282595;24009529;24619649;33095947;33682229;34428180;35196065", "class_list": "", "function": "Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22282595). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (PubMed:24619649)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Lineage tracing of cells expressing the ciliary gene IFT140 during bone development., [RefSeq, PubMed]; Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E., [RefSeq, PubMed]; The role of IFT140 in early bone healing of tooth extraction sockets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSU5;Q2XQY6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "GO:0007507 heart development;GO:0031076 embryonic camera-type eye development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9PY46-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SNZ0-1", "uniprot_id": [ { "id": "GRDN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SNZ0", "type": "external" } ], "mass": 215918.0, "length": 1873, "protein_name": "Girdin", "gene_name": "Ccdc88a", "organism": "Mouse", "refseq_name": "girdin isoform 3", "refseq_ac": [ { "id": "NP_789811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789811", "type": "external" } ], "gene_names_uniprotkb": "Ccdc88a; Grdn; Kiaa1212", "gene_names_refseq": "A430106J12Rik; Ape; C130096N06Rik; C330012F17Rik; Ccdc88a; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1", "protein_names_uniprotkb": "Girdin; APE; Akt phosphorylation enhancer; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; GIV; Girders of actin filament; HkRP1; Hook-related protein 1", "protein_names_refseq": "Akt-phosphorylation enhancer; Hook-related protein 1; coiled-coil domain-containing protein 88A; g alpha-interacting vesicle-associated protein; girders of actin filament; girdin isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:108686); (R-MMU-9696264); (R-MMU-9696273)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;15345747;15592455;15753085;15882442;17185515;18264090;18316593;19778506;20173027;21183079;21750661;22872234;25428506;25605945;26917597;27666957;31219806;32142853;33055214;34409938;34428180", "class_list": "", "function": "Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (By similarity). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (By similarity). Essential for cell migration (By similarity). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (By similarity). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (By similarity). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (PubMed:15753085). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton (By similarity). Required for formation of actin stress fibers and lamellipodia (By similarity). May be involved in membrane sorting in the early endosome (By similarity). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; GIV/Girdin, a non-receptor modulator for Galphai/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Girdin has an important role in tumor progression with aberrant activation of the Akt signaling pathway, [RefSeq, PubMed]; HkRP1 (A430106J12Rik) is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains., [RefSeq, PubMed]; MiR-328-3p inhibits cell proliferation and metastasis in colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt signaling pathway., [RefSeq, PubMed]; TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin., [RefSeq, PubMed]; The Akt/Girdin signalling pathway is essential in VEGF-mediated postneonatal angiogenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5M6X2;Q5M6X4;Q5M6X5;Q5SNZ1;Q8C486;Q8CFU7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005158 insulin receptor binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0007399 nervous system development;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0042127 regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q5SNZ0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C191-1", "uniprot_id": [ { "id": "GPVI_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C191", "type": "external" } ], "mass": 34595.0, "length": 313, "protein_name": "Platelet glycoprotein VI", "gene_name": "Gp6", "organism": "Mouse", "refseq_name": "platelet glycoprotein VI precursor", "refseq_ac": [ { "id": "NP_001156486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156486", "type": "external" } ], "gene_names_uniprotkb": "Gp6", "gene_names_refseq": "9830166G18Rik; Gm469; Gp6; Gpvi", "protein_names_uniprotkb": "Platelet glycoprotein VI; GPVI; Glycoprotein 5", "protein_names_refseq": "glycoprotein 5; platelet glycoprotein VI precursor; platelet glycoprotein VI", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); platelet-type bleeding disorder 11 (Disease Ontology:DOID:0111057); disseminated intravascular coagulation (Disease Ontology:DOID:11247); coronary thrombosis (Disease Ontology:DOID:11847); blood platelet disease (Disease Ontology:DOID:2218); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:243816); (R-MMU-114604); (R-MMU-75892)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10961879;16139873;16254207;21750661;24368846;37068592;37441848;38274818;38900973", "class_list": "", "function": "A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury., [RefSeq, PubMed]; Collagen receptor involved in collagen-induced platelet adhesion and activation (PubMed:16139873, PubMed:24368846). Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography., [RefSeq, PubMed]; Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QPN2", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005518 collagen binding;GO:1990782 protein tyrosine kinase binding;GO:0038064 collagen receptor activity;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045121 membrane raft;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0070527 platelet aggregation;GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway;GO:0038065 collagen-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0C191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A6A1-1", "uniprot_id": [ { "id": "GPTC8_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A6A1", "type": "external" } ], "mass": 164987.0, "length": 1505, "protein_name": "G patch domain-containing protein 8", "gene_name": "Gpatch8", "organism": "Mouse", "refseq_name": "G patch domain-containing protein 8", "refseq_ac": [ { "id": "NP_001152964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152964", "type": "external" } ], "gene_names_uniprotkb": "Gpatch8; Gpatc8; Kiaa0553", "gene_names_refseq": "5430405G24Rik; Fbm1; Gpatc8; Gpatch8; mKIAA0553", "protein_names_uniprotkb": "G patch domain-containing protein 8", "protein_names_refseq": "Fyn-binding molecule 1; G patch domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:237943)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;23806337;28528544;31599954;34418053;38688280", "class_list": "", "function": "GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q80TY1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030097 hemopoiesis;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A2A6A1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64521-1", "uniprot_id": [ { "id": "GPDM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64521", "type": "external" } ], "mass": 80954.0, "length": 727, "protein_name": "Glycerol-3-phosphate dehydrogenase, mitochondrial", "gene_name": "Gpd2", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001139292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139292", "type": "external" } ], "gene_names_uniprotkb": "Gpd2; Gdm1", "gene_names_refseq": "GPDH; Gdm1; Gpd-m; Gpd2; Gpdh-m; TISP38", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase, mitochondrial; 1.1.5.3; GPD-M; GPDH-M; Protein TISP38", "protein_names_refseq": "FAD-linked glycerol-3-phosphate dehydrogenase; glycerol phosphate dehydrogenase 1, mitochondrial; glycerol-3-phosphate dehydrogenase 2, mitochondrial; glycerol-3-phosphate dehydrogenase, mitochondrial precursor; glycerol-3-phosphate dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14571); (R-MMU-1483166); (R-MMU-163560)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;18034455;21750661;21952136;22872234;24788674;25428506;25605945;28135057;30084848;30779550;31209405;31219806;32152506;33300544;34428180;35820727;37166302;37453647;37507081;37828378;38256063;39927985;40021952;8772729;8951039", "class_list": "", "function": "Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV Replication via the TRIM28-Mediated Degradation of HBx., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK51;Q3UDY8;Q61507;Q8CBX6;Q8K4U5;Q8VDT0;Q9ERP0", "ec_number_list": [ { "id": "1.1.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.3", "type": "external" } ], "go_molecular_function": "GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006127 glycerol-3-phosphate shuttle;GO:0035264 multicellular organism growth;GO:0006094 gluconeogenesis;GO:0006072 glycerol-3-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q64521-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47743-1", "uniprot_id": [ { "id": "GRM8_MOUSE", "url": "https://www.uniprot.org/uniprot/P47743", "type": "external" } ], "mass": 101828.0, "length": 908, "protein_name": "Metabotropic glutamate receptor 8", "gene_name": "Grm8", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 8 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001298001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298001", "type": "external" } ], "gene_names_uniprotkb": "Grm8; Gprc1h; Mglur8", "gene_names_refseq": "A230002O04; GluR8; Gprc1h; Grm8; mGluR8", "protein_names_uniprotkb": "Metabotropic glutamate receptor 8; mGluR8", "protein_names_refseq": "G protein coupled receptor, family C, group 1, member H; metabotropic glutamate receptor 8 isoform 2 precursor; metabotropic glutamate receptor 8", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinsonism (Disease Ontology:DOID:0080855); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); autistic disorder (Disease Ontology:DOID:12849); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:14823); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12213278;12213279;15755905;16144832;21750661;25428506;33300544;34887587;38918065;7722646", "class_list": "", "function": "G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB]; Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice., [RefSeq, PubMed]; Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity. Publication Status: Online-Only, [RefSeq, PubMed]; The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6B964", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001642 group III metabotropic glutamate receptor activity;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0046928 regulation of neurotransmitter secretion;GO:0050966 detection of mechanical stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47743-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921N8-1", "uniprot_id": [ { "id": "GPS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921N8", "type": "external" } ], "mass": 36738.0, "length": 327, "protein_name": "G protein pathway suppressor 2", "gene_name": "Gps2", "organism": "Mouse", "refseq_name": "G protein pathway suppressor 2", "refseq_ac": [ { "id": "NP_062700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062700", "type": "external" } ], "gene_names_uniprotkb": "Gps2", "gene_names_refseq": "GPS-2; Gps2", "protein_names_uniprotkb": "G protein pathway suppressor 2; GPS-2", "protein_names_refseq": "G protein pathway suppressor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56310); (R-MMU-9029569); (R-MMU-9841922)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "18218630;20159957;21750661;22424771;22666460;24129315;24953653;25428506;25519902;26070566;27270589;28039360;28123943;29499132;32384137;32937117;33503407;34203471;34428180;36610795;36731652;40885482", "class_list": "", "function": "Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion., [RefSeq, PubMed]; Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4., [RefSeq, PubMed]; GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis., [RefSeq, PubMed]; GPS2 promotes erythroid differentiation by control of the stability of EKLF protein., [RefSeq, PubMed]; GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity., [RefSeq, PubMed]; Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (PubMed:22424771, PubMed:24953653, PubMed:28039360, PubMed:28123943, PubMed:29499132). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:18218630, PubMed:24953653, PubMed:25519902, PubMed:27270589, PubMed:28039360). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (PubMed:22666460, PubMed:24953653). Promotes cholesterol efflux by acting as a transcription coactivator (By similarity). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (PubMed:28039360). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:25519902). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (PubMed:27270589). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (By similarity). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (PubMed:22424771, PubMed:28123943). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF pathway; acts by repressing UBE2N/Ubc13 activity (PubMed:22424771). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (PubMed:28123943). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex, [RefSeq, PubMed]; The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010875 positive regulation of cholesterol efflux;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q921N8-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13745-1", "uniprot_id": [ { "id": "GSTA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P13745", "type": "external" } ], "mass": 25608.0, "length": 223, "protein_name": "Glutathione S-transferase A1", "gene_name": "Gsta1", "organism": "Mouse", "refseq_name": "glutathione S-transferase A1", "refseq_ac": [ { "id": "NP_032207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032207", "type": "external" } ], "gene_names_uniprotkb": "Gsta1; Gsta; Gstya", "gene_names_refseq": "Gst2-1; Gsta1", "protein_names_uniprotkb": "Glutathione S-transferase A1; 1.11.1.-; 13-hydroperoxyoctadecadienoate peroxidase; 2.5.1.18; 5.3.3.-; Androst-5-ene-3,17-dione isomerase; GST class-alpha member 1; Glutathione S-transferase Ya1; Glutathione S-transferase Ya", "protein_names_refseq": "13-hydroperoxyoctadecadienoate peroxidase; GST class-alpha member 1; androst-5-ene-3,17-dione isomerase; glutathione S-transferase A1; glutathione S-transferase Ya1; glutathione S-transferase Ya", "tax_id": 10090, "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:14857); (R-MMU-156590); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11027134;2049074;23647087;24964013;27198676;34428180;35820727;3652905;9606968", "class_list": "", "function": "GSTA1 can be detected at the early stage of low concentration ethanol exposure and that GSTA1 is more sensitive and reliable marker in ethanol-induced hepatic injury., [RefSeq, PubMed]; Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (PubMed:9606968). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Report increased GSTA1 in airways of asthmatic mice., [RefSeq, PubMed]; Results suggest that GSTA1 can be detected at low concentrations during the early stages of acute hepatic injury and that GSTA1 is a more sensitive and more accurate indicator than ALT, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTN4", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0004769 steroid Delta-isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009617 response to bacterium;GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:0035634 response to stilbenoid;GO:1901687 glutathione derivative biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P13745-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U6B2-1", "uniprot_id": [ { "id": "GP183_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U6B2", "type": "external" } ], "mass": 40185.0, "length": 357, "protein_name": "G protein-coupled receptor 183", "gene_name": "Gpr183", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 183", "refseq_ac": [ { "id": "NP_898852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898852", "type": "external" } ], "gene_names_uniprotkb": "Gpr183; Ebi2", "gene_names_refseq": "Ebi2; Gpr183", "protein_names_uniprotkb": "G protein-coupled receptor 183; EBI2; EBV-induced G protein-coupled receptor 2 homolog; Epstein-Barr virus-induced G protein-coupled receptor 2 homolog", "protein_names_refseq": "EBV-induced G-protein coupled receptor 2 homolog; Epstein-Barr virus induced gene 2; G-protein coupled receptor 183; epstein-Barr virus-induced G-protein coupled receptor 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:321019); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "12679517;19144319;19597478;19615922;21673108;21750661;21796211;21796212;21844396;21948984;22913878;23502855;23682316;25176650;25297897;26438360;27147029;27166278;37469011", "class_list": "", "function": "EBI2 provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses., [RefSeq, PubMed]; G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (PubMed:19597478, PubMed:19615922, PubMed:21796211, PubMed:21796212, PubMed:21844396, PubMed:27147029). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796211, PubMed:21796212). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (PubMed:21796211, PubMed:21796212, PubMed:27147029). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (PubMed:21796211, PubMed:21796212). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:21948984, PubMed:22913878). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (PubMed:19597478, PubMed:19615922, PubMed:21844396). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (PubMed:19615922). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (PubMed:27147029). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (PubMed:27147029). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (PubMed:23502855, PubMed:23682316). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897, PubMed:27166278). Promotes osteoclast precursor migration to bone surfaces (PubMed:26438360). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Important role for EBI2 in promoting B cell localization in the outer follicle, and show that differential expression of this receptor helps position B cells appropriately for mounting T-dependent antibody responses, [RefSeq, PubMed]; The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1F6;Q7TMV7;Q80T40", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0002312 B cell activation involved in immune response;GO:0036145 dendritic cell homeostasis;GO:2000458 regulation of astrocyte chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3U6B2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WT4-1", "uniprot_id": [ { "id": "GP176_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WT4", "type": "external" } ], "mass": 57143.0, "length": 515, "protein_name": "G protein-coupled receptor 176", "gene_name": "Gpr176", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 176", "refseq_ac": [ { "id": "NP_958755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958755", "type": "external" } ], "gene_names_uniprotkb": "Gpr176; Agr9; Gm1012", "gene_names_refseq": "Gm1012; Gpr176", "protein_names_uniprotkb": "G protein-coupled receptor 176; G protein-coupled receptor AGR9", "protein_names_refseq": "G-protein coupled receptor 176; G-protein coupled receptor AGR9; probable G-protein coupled receptor 176", "tax_id": 10090, "disease": "", "pathway": " (mmu:381413); (R-MMU-418555)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12679517;26882873;32152506;34203471;34428180;35908898;36905238;37828378", "class_list": "", "function": "GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer., [RefSeq, PubMed]; Gpr176 is an suprachiasmatic nucleus-enriched orphan G-protein-coupled receptors that sets the pace of circadian behavior. Publication Status: Online-Only, [RefSeq, PubMed]; Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity., [RefSeq, PubMed]; Orphan receptor involved in normal circadian rhythm behavior (PubMed:26882873). Acts through the G protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production (PubMed:26882873)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80UC4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0048512 circadian behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80WT4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGK7-1", "uniprot_id": [ { "id": "GNAL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGK7", "type": "external" } ], "mass": 44308.0, "length": 381, "protein_name": "Guanine nucleotide-binding protein G(olf) subunit alpha", "gene_name": "Gnal", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(olf) subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_034437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034437", "type": "external" } ], "gene_names_uniprotkb": "Gnal", "gene_names_refseq": "2610011C15Rik; 9630020G10Rik; Galphaolf; Gna10; Gnal; Golf; Hg1o", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(olf) subunit alpha; 3.6.5.-; Adenylate cyclase-stimulating G alpha protein, olfactory type", "protein_names_refseq": "G alpha 10; adenylate cyclase-stimulating G alpha protein, olfactory type; guanine nucleotide binding protein, alpha 10; guanine nucleotide-binding protein G(olf) subunit alpha isoform 1; guanine nucleotide-binding protein G(olf) subunit alpha; heterotrimeric guanine nucleotide-binding protein 1o", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); dystonia 25 (Disease Ontology:DOID:0090055); McCune Albright syndrome (Disease Ontology:DOID:1858); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:14680); (R-MMU-170660); (R-MMU-170670); (R-MMU-381753)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16754875;21183079;21467038;21750661;22645316;23994616;2508088;33300544;38062020;38960060;8858601;9459443", "class_list": "", "function": "Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (PubMed:16754875, PubMed:21467038, PubMed:9459443). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21467038). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:21467038). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21467038). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:21467038). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (PubMed:16754875, PubMed:9459443). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Neuron specific quantitation of Galphaolf expression and signaling in murine brain tissue., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61020;Q61589", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0001669 acrosomal vesicle;GO:0097225 sperm midpiece", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CGK7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1Z6-1", "uniprot_id": [ { "id": "GPR18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1Z6", "type": "external" } ], "mass": 37691.0, "length": 331, "protein_name": "N-arachidonyl glycine receptor", "gene_name": "Gpr18", "organism": "Mouse", "refseq_name": "N-arachidonyl glycine receptor", "refseq_ac": [ { "id": "NP_877958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877958", "type": "external" } ], "gene_names_uniprotkb": "Gpr18", "gene_names_refseq": "Gpr18", "protein_names_uniprotkb": "N-arachidonyl glycine receptor; G protein-coupled receptor 18; NAGly receptor", "protein_names_refseq": "N-arachidonyl glycine receptor; NAGly receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:110168); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21183079;22266325;23104136;23461720;25348153;26195725;26197390;27893106;34428180;35525326", "class_list": "", "function": "Data (including data from knockout mice) suggest that signal transduction involving GPR18 in corneal epithelium and ciliary epithelium is required for regulation of intraocular pressure., [RefSeq, PubMed]; Data indicate that orphan G-protein-coupled receptor GPR18 is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment., [RefSeq, PubMed]; G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems. Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis (PubMed:26195725). Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (PubMed:22266325). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (PubMed:25348153, PubMed:26197390). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (PubMed:27893106)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; GPR18 has a role in the development and reconstitution of thymus-derived intestinal IEL subsets in the steady-state and after bone marrow transplantation Publication Status: Online-Only, [RefSeq, PubMed]; The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9N3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0002300 CD8-positive, alpha-beta intraepithelial T cell differentiation;GO:0002689 negative regulation of leukocyte chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032720 negative regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K1Z6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXF8-1", "uniprot_id": [ { "id": "GNMT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXF8", "type": "external" } ], "mass": 32675.0, "length": 293, "protein_name": "Glycine N-methyltransferase", "gene_name": "Gnmt", "organism": "Mouse", "refseq_name": "glycine N-methyltransferase isoform 1", "refseq_ac": [ { "id": "NP_034451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034451", "type": "external" } ], "gene_names_uniprotkb": "Gnmt", "gene_names_refseq": "Gnmt", "protein_names_uniprotkb": "Glycine N-methyltransferase; 2.1.1.20", "protein_names_refseq": "glycine N methyl transferase; glycine N-methyltransferase isoform 1", "tax_id": 10090, "disease": "glycine N-methyltransferase deficiency (Disease Ontology:DOID:0111037); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14711); (R-MMU-389661)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15340920;16779654;17242355;21183079;23806337;29891549;30084848;31470507;32951289;34428180;37047834;37453647;9497905", "class_list": "", "function": "Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate (PubMed:15340920). Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine (PubMed:16779654)., [UniProtKB, PubMed, PubMed]; Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase. Publication Status: Online-Only, [RefSeq, PubMed]; GNMT deletion promotes a metabolic shift whereby nutrients are channeled away from glucose formation toward pathways that utilize the elevated S-adenosylmethionine., [RefSeq, PubMed]; Results suggest that glycine N-methyltransferase (GNMT) might be involved in insulin-induced angiopoietin-like protein 8 (Angptl8) expression in high fat diet (HFD)-mediated metabolic syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WN7", "ec_number_list": [ { "id": "2.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0017174 glycine N-methyltransferase activity;GO:0042802 identical protein binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0005542 folic acid binding;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005829 cytosol;GO:0034708 methyltransferase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0005977 glycogen metabolic process;GO:0006730 one-carbon metabolic process;GO:0032259 methylation;GO:0046498 S-adenosylhomocysteine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXF8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98192-1", "uniprot_id": [ { "id": "GNPAT_MOUSE", "url": "https://www.uniprot.org/uniprot/P98192", "type": "external" } ], "mass": 76870.0, "length": 678, "protein_name": "Dihydroxyacetone phosphate acyltransferase", "gene_name": "Gnpat", "organism": "Mouse", "refseq_name": "dihydroxyacetone phosphate acyltransferase", "refseq_ac": [ { "id": "NP_034452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034452", "type": "external" } ], "gene_names_uniprotkb": "Gnpat; Dhapat", "gene_names_refseq": "D1Ertd819e; DHAPAT; Gnpat", "protein_names_uniprotkb": "Dihydroxyacetone phosphate acyltransferase; 2.3.1.42; Acyl-CoA:dihydroxyacetonephosphateacyltransferase; DAP-AT; DHAP-AT; Glycerone-phosphate O-acyltransferase", "protein_names_refseq": "DAP-AT; DHAP-AT; acyl-CoA:dihydroxyacetonephosphateacyltransferase; dihydroxyacetone phosphate acyltransferase; glycerone-phosphate O-acyltransferase", "tax_id": 10090, "disease": "rhizomelic chondrodysplasia punctata type 2 (Disease Ontology:DOID:0110852); disease of mental health (Disease Ontology:DOID:150)", "pathway": " (mmu:14712); (R-MMU-1483166); (R-MMU-75896); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10395968;10456321;12874108;21183079;31219806;32108988;32766721;34428180", "class_list": "", "function": "Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology., [UniProtKB, PubMed]; Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression., [RefSeq, PubMed]; Gnpat does not play an essential role in systemic iron homeostasis in murine model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUT6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0030054 cell junction", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0008611 ether lipid biosynthetic process;GO:0042552 myelination;GO:0061024 membrane organization;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P98192-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0QWG9-1", "uniprot_id": [ { "id": "GRD2I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0QWG9", "type": "external" } ], "mass": 132021.0, "length": 1203, "protein_name": "Delphilin", "gene_name": "Grid2ip", "organism": "Mouse", "refseq_name": "delphilin isoform 1", "refseq_ac": [ { "id": "NP_001152793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152793", "type": "external" } ], "gene_names_uniprotkb": "Grid2ip", "gene_names_refseq": "Grid2ip", "protein_names_uniprotkb": "Delphilin; Glutamate receptor, ionotropic, delta 2-interacting protein 1", "protein_names_refseq": "GluR-delta2 philic-protein; L-delphilin; delphilin isoform 1; glutamate receptor, ionotropic, delta 2-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170935)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11826110;12372286;12628171;16168524;16835239;17027646;17425562;17496809;18509461;21183079;34678516", "class_list": "", "function": "A direct link exists between GluR2delta receptor and stimulation of the autophagic pathway in dying Purkinje cells of lurcher mice., [RefSeq, PubMed]; Absence of GRID2 receptors in heteroallelic mutants induces an early and massive Purkinje cell death that is correlated with early signs of autophagy and is independent of depolarization., [RefSeq, PubMed]; Findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in optokinetic resonse gain-increase adaptation, a simple form of motor learning Publication Status: Online-Only, [RefSeq, PubMed]; Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules., [UniProtKB]; Results show that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6DID0;Q9ESJ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0043197 dendritic spine;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0060292 long-term synaptic depression;GO:0030036 actin cytoskeleton organization;GO:0007216 G protein-coupled glutamate receptor signaling pathway;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q0QWG9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70326-1", "uniprot_id": [ { "id": "GREM1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70326", "type": "external" } ], "mass": 20710.0, "length": 184, "protein_name": "Gremlin-1", "gene_name": "Grem1", "organism": "Mouse", "refseq_name": "gremlin-1 precursor", "refseq_ac": [ { "id": "NP_035954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035954", "type": "external" } ], "gene_names_uniprotkb": "Grem1; Cktsf1b1; Drm", "gene_names_refseq": "Cktsf1b1; Drm; Grem1; Grem; ld", "protein_names_uniprotkb": "Gremlin-1; Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein", "protein_names_refseq": "cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; gremlin-1 precursor; gremlin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23892)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10965135;12808456;15133038;15201225;9660951", "class_list": "", "function": "Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop (PubMed:12808456, PubMed:15201225). Down-regulates the BMP4 signaling in a dose-dependent manner (PubMed:15133038). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding;GO:0005125 cytokine activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0002689 negative regulation of leukocyte chemotaxis;GO:0046851 negative regulation of bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70326-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8V0-1", "uniprot_id": [ { "id": "SPP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8V0", "type": "external" } ], "mass": 41748.0, "length": 378, "protein_name": "Signal peptide peptidase", "gene_name": "H13; Hm13", "organism": "Mouse", "refseq_name": "signal peptide peptidase isoform 1", "refseq_ac": [ { "id": "NP_001153023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153023", "type": "external" } ], "gene_names_uniprotkb": "H13; Hm13; H13; Psl3; SPP", "gene_names_refseq": "1200006O09Rik; 4930443L17Rik; 5031424B04Rik; H-13; H13; Hm13; PSL3; Spp", "protein_names_uniprotkb": "Signal peptide peptidase; 3.4.23.-; Minor histocompatibility antigen H13; Presenilin-like protein 3; Signal peptide peptidase-like 1", "protein_names_refseq": "minor histocompatibility antigen H13; presenilin-like aspartyl protease; presenilin-like protein 3; signal peptide peptidase beta; signal peptide peptidase isoform 1; signal peptide peptidase-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14950); (R-MMU-9707587)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11751972;12972007;15699113;16730383;19720873;20018625;21750661;22872234;25428506;25605945;30084848;31219806;34428180;35820727;9354467", "class_list": "", "function": "Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (By similarity). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (By similarity). May play a role in graft rejection (PubMed:9354467)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3KGS1;O19444;Q15K37;Q3TXP0;Q542R3;Q811Z6;Q8HWA9;Q8HWB5;Q9CQA4;Q9CSK9", "ec_number_list": [ { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0008233 peptidase activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol;GO:0033619 membrane protein proteolysis;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D8V0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41136-1", "uniprot_id": [ { "id": "ID2_MOUSE", "url": "https://www.uniprot.org/uniprot/P41136", "type": "external" } ], "mass": 14959.0, "length": 134, "protein_name": "DNA-binding protein inhibitor ID-2", "gene_name": "Id2", "organism": "Mouse", "refseq_name": "DNA-binding protein inhibitor ID-2", "refseq_ac": [ { "id": "NP_034626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034626", "type": "external" } ], "gene_names_uniprotkb": "Id2; Id-2; Idb2", "gene_names_refseq": "Id2; Idb2; bHLHb26", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-2; Inhibitor of DNA binding 2; Inhibitor of differentiation 2", "protein_names_refseq": "DNA-binding protein inhibitor ID-2; inhibitor of differentiation 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15902)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11940648;15563451;16556596;19217292;1922066;19609365;19740747;20861012;21183079;21750661;21947283;34428180;9831657", "class_list": "", "function": "Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88604", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0044325 transmembrane transporter binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000791 euchromatin", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0043353 enucleate erythrocyte differentiation;GO:0003166 bundle of His development;GO:0061031 endodermal digestive tract morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P41136-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07750-1", "uniprot_id": [ { "id": "IL4_MOUSE", "url": "https://www.uniprot.org/uniprot/P07750", "type": "external" } ], "mass": 15834.0, "length": 140, "protein_name": "Interleukin-4", "gene_name": "Il4", "organism": "Mouse", "refseq_name": "interleukin-4 precursor", "refseq_ac": [ { "id": "NP_067258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067258", "type": "external" } ], "gene_names_uniprotkb": "Il4; Il-4", "gene_names_refseq": "BSF-1; Il-4; Il4", "protein_names_uniprotkb": "Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; IL-4; Lymphocyte stimulatory factor 1", "protein_names_refseq": "B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; interleukin-4 precursor; lymphocyte stimulatory factor 1", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); alopecia universalis (Disease Ontology:DOID:0050634); stroke (Disease Ontology:DOID:0051061); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); pelvic inflammatory disease (Disease Ontology:DOID:1003); trypanosomiasis (Disease Ontology:DOID:10113); dermatomyositis (Disease Ontology:DOID:10223); Alzheimer's disease (Disease Ontology:DOID:10652); nephritis (Disease Ontology:DOID:10952); anogenital venereal wart (Disease Ontology:DOID:11168); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Sjogren's syndrome (Disease Ontology:DOID:12894); carotid stenosis (Disease Ontology:DOID:13001); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); cognitive disorder (Disease Ontology:DOID:1561); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); irritant dermatitis (Disease Ontology:DOID:2772); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); autoimmune thyroiditis (Disease Ontology:DOID:7188); herpes zoster (Disease Ontology:DOID:8536); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); leishmaniasis (Disease Ontology:DOID:9065); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744); toxocariasis (Disease Ontology:DOID:9790)", "pathway": " (mmu:16189); (R-MMU-6785807)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1993171;21750661;25772794;25847241;26416964;28202615;3005865;3029676;3083412;3498301;8624821", "class_list": "", "function": "Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:3083412). Induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964). In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (PubMed:25772794, PubMed:28202615). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is also expressed on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:25847241, PubMed:8624821)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005136 interleukin-4 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0016516 interleukin-4 receptor complex;GO:0005576 extracellular region", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0002677 negative regulation of chronic inflammatory response;GO:0010633 negative regulation of epithelial cell migration;GO:0032736 positive regulation of interleukin-13 production;GO:0035771 interleukin-4-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07750-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26955-1", "uniprot_id": [ { "id": "IL3RB_MOUSE", "url": "https://www.uniprot.org/uniprot/P26955", "type": "external" } ], "mass": 99036.0, "length": 896, "protein_name": "Cytokine receptor common subunit beta", "gene_name": "Csf2rb", "organism": "Mouse", "refseq_name": "cytokine receptor common subunit beta precursor", "refseq_ac": [ { "id": "NP_031806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031806", "type": "external" } ], "gene_names_uniprotkb": "Csf2rb; Aic2b; Csf2rb1; Il3rb1", "gene_names_refseq": "AIC2B; Bc; CDw131; Csf2rb1; Csf2rb; Csfgmrb; Il3rb1; Il3rb; Il3r; Il5rb", "protein_names_uniprotkb": "Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit", "protein_names_refseq": "CD131 antigen; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; beta c; colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage); common beta chain; cytokine receptor common subunit beta precursor; cytokine receptor common subunit beta", "tax_id": 10090, "disease": "pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:12983); (R-MMU-512988); (R-MMU-5673001); (R-MMU-912526)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10477686;10672044;1695379;17947660;18250455;19098920;21750661;28011936;28935714;32152506;34428180;35984892;36210013", "class_list": "", "function": "High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7L5", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0038043 interleukin-5-mediated signaling pathway;GO:0038156 interleukin-3-mediated signaling pathway;GO:0001558 regulation of cell growth;GO:0019221 cytokine-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P26955-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWX6-1", "uniprot_id": [ { "id": "IF2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWX6", "type": "external" } ], "mass": 36108.0, "length": 315, "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "Eif2s1", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2 subunit 1", "refseq_ac": [ { "id": "NP_080390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080390", "type": "external" } ], "gene_names_uniprotkb": "Eif2s1; Eif2a", "gene_names_refseq": "0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a; Eif2s1; eIF2alpha", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha", "protein_names_refseq": "eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2A", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); leukodystrophy (Disease Ontology:DOID:10579); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:13665); (R-MMU-156827); (R-MMU-381042); (R-MMU-382556); (R-MMU-72649); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-72731); (R-MMU-9840373)", "pathway_count": 10, "publication_count": 24, "publication_id_list": "10504407;10882126;11106749;12176355;15213227;15277680;16054071;16418533;16931514;19131336;19861488;21183079;21285359;22645316;25428506;31219806;32782141;34428180;34678516;35822049;37453647;37507081;40885482;9930704", "class_list": "", "function": "Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:15277680, PubMed:19131336). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (PubMed:15277680, PubMed:19131336). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:15277680, PubMed:19131336). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:15277680, PubMed:19131336). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:15277680, PubMed:21285359). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIQ0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0160296 cap-dependent translation initiation factor activity;GO:0160297 IRES-mediated translation initiation factor activity", "go_cellular_component": "GO:0044207 translation initiation ternary complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0034605 cellular response to heat;GO:0046777 protein autophosphorylation;GO:0006413 translational initiation;GO:0034599 cellular response to oxidative stress;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q6ZWX6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBR1-1", "uniprot_id": [ { "id": "ILDR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBR1", "type": "external" } ], "mass": 61277.0, "length": 537, "protein_name": "Immunoglobulin-like domain-containing receptor 1", "gene_name": "Ildr1", "organism": "Mouse", "refseq_name": "immunoglobulin-like domain-containing receptor 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001272717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272717", "type": "external" } ], "gene_names_uniprotkb": "Ildr1", "gene_names_refseq": "Ildr1", "protein_names_uniprotkb": "Immunoglobulin-like domain-containing receptor 1; Angulin-2", "protein_names_refseq": "angulin-2; immunoglobulin-like domain-containing receptor 1 isoform 1 precursor", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 42 (Disease Ontology:DOID:0110500)", "pathway": " (mmu:106347)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21255762;23239027;23863714;25217574;28785060;32782141;35749484", "class_list": "", "function": "ILDR1 regulates CCK release through a mechanism dependent on fatty acids and lipoproteins., [RefSeq, PubMed]; Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia. Publication Status: Online-Only, [RefSeq, PubMed]; Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs (PubMed:25217574). Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine (PubMed:23863714). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study consolidate the importance of ILDR1 as a tight junction protein necessary for cochlear hair cells survival, and the integrity of the auditory system., [RefSeq, PubMed]; The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR, ILDR1 or ILDR2, and suggest that ILDR1-mediated recruitment of tricellulin to TCs is required for hearing. Erratum:[J Cell Sci. 2013 Aug 15;126(Pt 16):3797], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFB3;Q8CB39;Q91VS0", "ec_number_list": [], "go_molecular_function": "GO:0070506 high-density lipoprotein particle receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061833 protein localization to tricellular tight junction;GO:1904274 tricellular tight junction assembly;GO:1990830 cellular response to leukemia inhibitory factor;GO:0043484 regulation of RNA splicing;GO:0070542 response to fatty acid", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CBR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "W8DXL4-1", "uniprot_id": [ { "id": "LRIT3_MOUSE", "url": "https://www.uniprot.org/uniprot/W8DXL4", "type": "external" } ], "mass": 74827.0, "length": 681, "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3", "gene_name": "Lrit3", "organism": "Mouse", "refseq_name": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_001274153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274153", "type": "external" } ], "gene_names_uniprotkb": "Lrit3", "gene_names_refseq": "Gm421; Lrit3", "protein_names_uniprotkb": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3", "protein_names_refseq": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 precursor; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3", "tax_id": 10090, "disease": "congenital stationary night blindness 1F (Disease Ontology:DOID:0110864)", "pathway": " (mmu:242235)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;24598786;25997951;26427409;28334377;31959619", "class_list": "", "function": "LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (PubMed:25997951, PubMed:26427409, PubMed:28334377). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:26427409, PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (PubMed:25997951). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (PubMed:28334377). May also have a role in cone synapse formation (PubMed:25997951, PubMed:28334377). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (By similarity). Could be a regulator of the FGFRs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The stationary no b-wave phenotype of mice lacking Lrit3, which we named nob6, confirms the findings previously reported in patients carrying LRIT3 mutations. Publication Status: Online-Only, [RefSeq, PubMed]; This study confirmed the localization of LRIT3 at the dendritic tips of depolarizing bipolar cells in mouse retina and demonstrated the dependence of TRPM1 localization on the presence of LRIT3., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0051286 cell tip;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0007601 visual perception;GO:0008104 intracellular protein localization;GO:0009416 response to light stimulus;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "W8DXL4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFW7-1", "uniprot_id": [ { "id": "LPP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFW7", "type": "external" } ], "mass": 65891.0, "length": 613, "protein_name": "Lipoma-preferred partner homolog", "gene_name": "Lpp", "organism": "Mouse", "refseq_name": "lipoma-preferred partner homolog isoform 1", "refseq_ac": [ { "id": "NP_001139424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139424", "type": "external" } ], "gene_names_uniprotkb": "Lpp", "gene_names_refseq": "9430020K16Rik; B130055L10Rik; D630048H16; Lpp", "protein_names_uniprotkb": "Lipoma-preferred partner homolog", "protein_names_refseq": "lipoma preferred partner; lipoma-preferred partner homolog isoform 1; lipoma-preferred partner homolog", "tax_id": 10090, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:210126)", "pathway_count": 1, "publication_count": 36, "publication_id_list": "10.3389/fragi.2021.757801;12441356;15592455;17947660;18515860;19131326;21540332;21750661;22645316;23443134;23806337;24129315;25153642;26192747;28135057;28528544;29237092;29251630;30059200;30084848;31219806;32299913;32782141;32848054;34678516;34887587;35820727;35822049;36288343;36852467;37453647;39927985;40021952;40885482;40997131;9696033", "class_list": "", "function": "Cancer-associated fibroblasts regulate endothelial LPP via a calcium-dependent signaling pathway involving microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP, [RefSeq, PubMed]; LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity [LIM-containing lipoma-preferred partner [LPP], [RefSeq, PubMed]; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity)., [UniProtKB]; The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q5U407;Q8BHI1;Q8BKI0;Q8BKN2;Q8BLF4;Q8BLG3;Q8C101", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0001725 stress fiber", "go_biological_process": "GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q8BFW7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60641-1", "uniprot_id": [ { "id": "NR1H4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60641", "type": "external" } ], "mass": 55994.0, "length": 488, "protein_name": "Bile acid receptor", "gene_name": "Nr1h4", "organism": "Mouse", "refseq_name": "bile acid receptor isoform 2", "refseq_ac": [ { "id": "NP_001156976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156976", "type": "external" } ], "gene_names_uniprotkb": "Nr1h4; Bar; Fxr; Rip14", "gene_names_refseq": "Fxr; HRR1; Nr1h4; RIP14; Rxrip14", "protein_names_uniprotkb": "Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; RXR-interacting protein 14; Retinoid X receptor-interacting protein 14", "protein_names_refseq": "RXR-interacting protein 14; bile acid receptor isoform 2; bile acid receptor; farnesoid X activated receptor; farnesol receptor HRR-1; retinoid X receptor-interacting protein 14", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis 5 (Disease Ontology:DOID:0070225); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20186); (R-MMU-159418); (R-MMU-192105); (R-MMU-193368); (R-MMU-193807); (R-MMU-211976); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 8, "publication_count": 40, "publication_id_list": "11030617;11579204;11706036;12004058;12393883;12421815;12660231;12891557;14729567;15146238;15564327;16213224;16410358;16446356;16473946;16557297;16946559;18842595;18972444;19047134;19393742;19805516;19864602;19883617;20091679;20447400;20483916;21242261;21383957;21804189;22057115;22820415;23372731;24037988;25545350;25651182;26505219;31043434;34428180;7760852", "class_list": "", "function": "Activates transcription of IBAP and SDC1., [UniProtKB, PubMed]; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved in innate immune response (PubMed:11030617, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (PubMed:20091679, PubMed:20483916). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (PubMed:21383957, PubMed:25545350, PubMed:25651182). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:21383957). In ileal enterocytes activates FABP6/IBABP (involved in cytosolic transport), SLC51A/OSTA and SLC51B/OSTB (involved in secretion of conjugated BAs to the portal blood), and repressor NR0B2/SHP thereby indirectly inhibiting SLC10A2/ASBT (involved in BA uptake) (By similarity). In the intestine activates FGF15 expression and secretion leading to hepatic CYP7A1 repression; the function also involves the coordinated induction of hepatic KLB/beta-klotho expression (PubMed:16213224, PubMed:26505219). Transcriptional activation of FABP6/IBAP and SCD1 but not of ABCB11 is isoform-specific (PubMed:12393883). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (By similarity). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 isoform SREBP-1C (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly) (PubMed:12421815, PubMed:15146238). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 probably involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557, PubMed:15146238). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:15564327, PubMed:16410358, PubMed:16446356, PubMed:16557297, PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (PubMed:16473946, PubMed:21242261). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:19864602). Mediates transrepression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (By similarity). Involved in the TLR9-mediated protective mechanism in intestinal inflammation (PubMed:23372731). Plays a anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling (PubMed:18972444)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YTT2;E9QJW2;Q60642;Q60643", "ec_number_list": [], "go_molecular_function": "GO:1902122 chenodeoxycholic acid binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0043235 receptor complex", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0032703 negative regulation of interleukin-2 production;GO:0032740 positive regulation of interleukin-17 production;GO:0038185 nuclear receptor-mediated bile acid signaling pathway;GO:1905695 positive regulation of phosphatidic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q60641-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM13-1", "uniprot_id": [ { "id": "NOE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM13", "type": "external" } ], "mass": 50720.0, "length": 448, "protein_name": "Noelin-2", "gene_name": "Olfm2", "organism": "Mouse", "refseq_name": "noelin-2 isoform 3 precursor", "refseq_ac": [ { "id": "NP_776138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776138", "type": "external" } ], "gene_names_uniprotkb": "Olfm2", "gene_names_refseq": "A030009A06Rik; Olfm2", "protein_names_uniprotkb": "Noelin-2; Olfactomedin-2", "protein_names_refseq": "noelin-2 isoform 3 precursor; noelin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244723)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21228389;21750661;22632720;22645316;25218043;28062493;30899004;33300544;34428180", "class_list": "", "function": "Highly conserved OLFM2 protein may play an important role in the course of retinal and eye development. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation (By similarity). TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (By similarity). Plays a role in AMPAR complex organization (PubMed:25218043). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; These results suggest that heterodimers of Olfm1 and Olfm2 interact with AMPAR more efficiently than Olfm2 homodimers and that Olfm2 plays a role in the organization of the AMPA receptor complexes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q0VFZ0;Q0VG58", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1905174 regulation of vascular associated smooth muscle cell dedifferentiation;GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0007601 visual perception;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BM13-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1XH17-1", "uniprot_id": [ { "id": "TRI72_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1XH17", "type": "external" } ], "mass": 52817.0, "length": 477, "protein_name": "Tripartite motif-containing protein 72", "gene_name": "Trim72", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 72", "refseq_ac": [ { "id": "NP_001073401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073401", "type": "external" } ], "gene_names_uniprotkb": "Trim72; Mg53", "gene_names_refseq": "MG53; Trim72", "protein_names_uniprotkb": "Tripartite motif-containing protein 72; 2.3.2.27; Mg53; Mitsugumin-53", "protein_names_refseq": "mitsugumin 53; tripartite motif-containing protein 72", "tax_id": 10090, "disease": "", "pathway": " (mmu:434246)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19029292;19043407;19202355;19380584;20139895;36288343;37507081;37770719;38552849;38843641;39267782", "class_list": "", "function": "Co-expression studies indicated that MG53 activity is regulated by a functional interaction with caveolin-3, [RefSeq, PubMed]; Intracellular vesicle translocation and Ca(2+)-dependent membrane fusion are distinct steps involved in the repair of membrane damage; MG53 may initiate the assembly of the membrane repair machinery in an oxidation-dependent manner., [RefSeq, PubMed]; MG53 binding to CAV3 facilitates activation of eNOS/NO signaling pathway to enhance the therapeutic benefits of bone marrow-derived mesenchymal stem cells in diabetic wound healing., [RefSeq, PubMed]; MG53 protects against Coxsackievirus B3-induced acute viral myocarditis in mice by inhibiting NLRP3 inflammasome-mediated pyroptosis via the NF-kappaB signaling pathway., [RefSeq, PubMed]; Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular complex formed by MG53, dysferlin, and Cav3 is essential for repair of muscle membrane damage in muscular dystrophy., [RefSeq, PubMed]; Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:19043407, PubMed:37770719). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (PubMed:37770719). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (PubMed:19043407, PubMed:19202355). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (PubMed:19043407). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (PubMed:19043407). Required for transport of DYSF to sites of cell injury during repair patch formation (PubMed:19043407). Regulates membrane budding and exocytosis (PubMed:19029292). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (PubMed:19202355)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Suggest MG53 is involved in a constitutive cycle of cell-surface proteins between the plasma membrane and endosome-like vesicles in striated muscle, and also that the vesicular dynamics are essential for the quality control of KV2.1 in cardiomyocytes., [RefSeq, PubMed]; TRIM72 is a novel antagonist of IRS-1, and is essential as a negative regulator of IGF-induced muscle differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWH7;Q6NX76", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0001786 phosphatidylserine binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030659 cytoplasmic vesicle membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q1XH17-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z4R4-1", "uniprot_id": [ { "id": "D3Z4R4_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z4R4", "type": "external" } ], "mass": 29362.0, "length": 277, "protein_name": "NK6 homeobox 2", "gene_name": "Nkx6-2", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-6.2", "refseq_ac": [ { "id": "NP_899071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899071", "type": "external" } ], "gene_names_uniprotkb": "Nkx6-2", "gene_names_refseq": "Gtx; Nkx6-2; Nkx6.2", "protein_names_uniprotkb": "NK6 homeobox 2", "protein_names_refseq": "Drosophila NK transcription factor related, gene family 6, locus 2; NK6 transcription factor related, locus 2; glial and testis specific homeobox; homeobox protein Nkx-6.2", "tax_id": 10090, "disease": "spastic ataxia 8 (Disease Ontology:DOID:0080252); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14912)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37945756", "class_list": "", "function": "Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0010454 negative regulation of cell fate commitment;GO:0010455 positive regulation of cell fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z4R4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR69-3", "uniprot_id": [ { "id": "CRACD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5PR69", "type": "external" } ], "mass": 142885.0, "length": 1291, "protein_name": "Capping protein-inhibiting regulator of actin dynamics", "gene_name": "Cracd", "organism": "Mouse", "refseq_name": "capping protein-inhibiting regulator of actin dynamics isoform 2", "refseq_ac": [ { "id": "NP_001157265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157265", "type": "external" } ], "gene_names_uniprotkb": "Cracd; Crad; Kiaa1211", "gene_names_refseq": "2810489J07Rik; 4930529A19Rik; 4931405B09Rik; C530008M17Rik; Cracd; Crad; Gm10430; mKIAA1211", "protein_names_uniprotkb": "Capping protein-inhibiting regulator of actin dynamics; Cancer-related regulator of actin dynamics", "protein_names_refseq": "cancer-related regulator of actin dynamics; capping protein inhibiting regulator of actin dynamics; capping protein-inhibiting regulator of actin dynamics isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320827)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;26495903;30361697;38796854", "class_list": "", "function": "CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma., [RefSeq, PubMed]; Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton (PubMed:30361697). Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q3Y7;E9Q5L4;E9QLP4;Q80TH6;Q8C7K8;Q8C7R0;Q8C9F2;Q8CDM6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium;GO:0030838 positive regulation of actin filament polymerization;GO:0010669 epithelial structure maintenance;GO:2000813 negative regulation of barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5PR69-3", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55176-3", "uniprot_id": [ { "id": "PJA1_MOUSE", "url": "https://www.uniprot.org/uniprot/O55176", "type": "external" } ], "mass": 63906.0, "length": 578, "protein_name": "E3 ubiquitin-protein ligase Praja-1", "gene_name": "Pja1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Praja-1 isoform 1", "refseq_ac": [ { "id": "NP_001076579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076579", "type": "external" } ], "gene_names_uniprotkb": "Pja1", "gene_names_refseq": "Pja1; praja-1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Praja-1; 2.3.2.27; Praja1; RING-type E3 ubiquitin transferase Praja-1", "protein_names_refseq": "E3 ubiquitin-protein ligase Praja-1 isoform 1; E3 ubiquitin-protein ligase Praja-1; RING-type E3 ubiquitin transferase Praja-1; praja ring finger 1, E3 ubiquitin protein ligase; praja1, RING-H2 motif containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:18744); (R-MMU-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10500182;11533224;11959851;12036302;21183079;37712419;9393880", "class_list": "", "function": "Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting., [UniProtKB, PubMed, PubMed]; PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFU2;Q99MJ1;Q99MJ2;Q99MJ3;Q9DB04", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O55176-3", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAN7-1", "uniprot_id": [ { "id": "PRR18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAN7", "type": "external" } ], "mass": 32214.0, "length": 307, "protein_name": "Proline-rich protein 18", "gene_name": "Prr18", "organism": "Mouse", "refseq_name": "proline-rich protein 18 isoform 1", "refseq_ac": [ { "id": "NP_848889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848889", "type": "external" } ], "gene_names_uniprotkb": "Prr18", "gene_names_refseq": "9630019K15Rik; Prr18", "protein_names_uniprotkb": "Proline-rich protein 18", "protein_names_refseq": "proline rich region 18; proline-rich protein 18 isoform 1; proline-rich protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:320111)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;24129315", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR84;Q8CA32;Q8CBI5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PAN7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YR9-1", "uniprot_id": [ { "id": "PTGR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YR9", "type": "external" } ], "mass": 35560.0, "length": 329, "protein_name": "Prostaglandin reductase 1", "gene_name": "Ptgr1", "organism": "Mouse", "refseq_name": "prostaglandin reductase 1", "refseq_ac": [ { "id": "NP_080244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080244", "type": "external" } ], "gene_names_uniprotkb": "Ptgr1; Ltb4dh", "gene_names_refseq": "2510002C21Rik; DIG-1; Ltb4dh; Ptgr1; Zadh3", "protein_names_uniprotkb": "Prostaglandin reductase 1; 1.3.1.48; 1.3.1.74; 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; DIG-1; Dithiolethione-inducible gene 1 protein; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase; PRG-1", "protein_names_refseq": "15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; dithiolethione-inducible gene 1 protein; leukotriene B4 12-hydroxydehydrogenase; prostaglandin reductase 1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:67103)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23806337;27802388;34428180", "class_list": "", "function": "NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKT6;Q9CPS1", "ec_number_list": [ { "id": "1.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48", "type": "external" }, { "id": "1.3.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74", "type": "external" } ], "go_molecular_function": "GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity;GO:0035798 2-alkenal reductase (NADPH) activity;GO:0036185 13-lipoxin reductase activity;GO:0097257 leukotriene B4 12-hydroxy dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0006693 prostaglandin metabolic process;GO:0050928 negative regulation of positive chemotaxis;GO:0036102 leukotriene B4 metabolic process;GO:2001302 lipoxin A4 metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91YR9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI15-1", "uniprot_id": [ { "id": "SPHK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI15", "type": "external" } ], "mass": 42443.0, "length": 382, "protein_name": "Sphingosine kinase 1", "gene_name": "Sphk1", "organism": "Mouse", "refseq_name": "sphingosine kinase 1 isoform 2", "refseq_ac": [ { "id": "NP_001165943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165943", "type": "external" } ], "gene_names_uniprotkb": "Sphk1; Sk1", "gene_names_refseq": "1110006G24Rik; Sk1; Sphk1; Spk1", "protein_names_uniprotkb": "Sphingosine kinase 1; 2.3.1.-; 2.7.1.91; Acetyltransferase SPHK1; SK 1; SPK 1", "protein_names_refseq": "acetyltransferase SPHK1; sphingosine kinase 1 isoform 2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); adenocarcinoma (Disease Ontology:DOID:299); high grade glioma (Disease Ontology:DOID:3070); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20698); (R-MMU-1660661); (R-MMU-390471); (R-MMU-5218921); (R-MMU-9009391); (R-MMU-9833482)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "12077123;12391145;15196915;15459201;16118219;16314531;16368679;16623665;17346996;17643421;21084291;21750661;24929359;25417698;27806293;28049734;29662056;33334894;9726979", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions (PubMed:17346996, PubMed:21084291, PubMed:25417698, PubMed:29662056, PubMed:33334894). Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:9726979). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling (By similarity). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (By similarity). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:27806293, PubMed:28049734). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data describe a novel mechanism by which vascular endothelial growth factor induces DNA synthesis in a pathway where sphingosine kinase mediates signaling from protein kinase C to Ras in a manner independent of Ras-guanine nucleotide exchange factor., [RefSeq, PubMed]; Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia., [UniProtKB, PubMed]; Results suggest that export of Sphk-1a isoform occurs under physiological conditions and may contribute to the establishment of the vascular S1P gradient., [RefSeq, PubMed]; SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization., [RefSeq, PubMed]; Sphingosine kinase 1 is a component of the copper-dependent FGF1 release pathway., [RefSeq, PubMed]; This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88886;Q3U2E3;Q91ZN3", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0005929 cilium", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006670 sphingosine metabolic process;GO:0032740 positive regulation of interleukin-17 production;GO:1900060 negative regulation of ceramide biosynthetic process;GO:0032651 regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8CI15-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZX8-1", "uniprot_id": [ { "id": "RS19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZX8", "type": "external" } ], "mass": 16085.0, "length": 145, "protein_name": "Small ribosomal subunit protein eS19", "gene_name": "Rps19", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS19 isoform a", "refseq_ac": [ { "id": "NP_075622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075622", "type": "external" } ], "gene_names_uniprotkb": "Rps19", "gene_names_refseq": "Dsk3; Rps19", "protein_names_uniprotkb": "Small ribosomal subunit protein eS19; 40S ribosomal protein S19", "protein_names_refseq": "40S ribosomal protein S19; small ribosomal subunit protein eS19 isoform a; small ribosomal subunit protein eS19", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 1 (Disease Ontology:DOID:0111895); aplastic anemia (Disease Ontology:DOID:12449); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:20085); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "12393682;16289379;19200342;21750661;22645316;23806337;31219806;34428180;35820727;36288343;36517592;37453647;37507081;37828378", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (By similarity). Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; RPS19 mRNA and protein expression were shown to decrease during terminal erythroid differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9J4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007000 nucleolus organization;GO:0007219 Notch signaling pathway;GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CZX8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UE6-1", "uniprot_id": [ { "id": "WNK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UE6", "type": "external" } ], "mass": 132410.0, "length": 1222, "protein_name": "Serine/threonine-protein kinase WNK4", "gene_name": "Wnk4", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase WNK4", "refseq_ac": [ { "id": "NP_783569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783569", "type": "external" } ], "gene_names_uniprotkb": "Wnk4; Prkwnk4", "gene_names_refseq": "2010002J11Rik; Pha2b; Prkwnk4; Wnk4", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK4; 2.7.11.1; Protein kinase lysine-deficient 4; Protein kinase with no lysine 4", "protein_names_refseq": "protein kinase with no lysine 4; protein kinase, lysine deficient 4; serine/threonine-protein kinase WNK4", "tax_id": 10090, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:69847)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11498583;12515852;12671053;14608358;14769928;16403833;16964266;17360470;17488636;17673510;17975670;19240212;19633012;21183079;21317537;21486947;21750661;23453970;23576762;25428506;31219806;32782141;33439774;34428180;34887587;36852467;37481568", "class_list": "", "function": "General role for WNK4 in the regulation of electrolyte flux in diverse epithelia, [RefSeq, PubMed]; KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (PubMed:12515852, PubMed:14608358, PubMed:16964266, PubMed:17360470, PubMed:17488636, PubMed:17975670, PubMed:19240212, PubMed:19633012, PubMed:21486947). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:21486947). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17488636, PubMed:19633012, PubMed:21486947). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (PubMed:14608358, PubMed:16964266, PubMed:17975670). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (PubMed:14608358, PubMed:17488636, PubMed:17975670, PubMed:19633012, PubMed:21486947). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (PubMed:14608358, PubMed:16403833, PubMed:17673510, PubMed:21317537). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (PubMed:17360470). May also phosphorylate NEDD4L (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; WNK4 has a role in the sodium regulatory pathway of the distal, [RefSeq, PubMed]; WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2A4J7;Q4VAC1;Q80XB5;Q80XN2;Q8R0N0;Q8R340", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031404 chloride ion binding;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0044297 cell body", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0003096 renal sodium ion transport;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q80UE6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AP18-1", "uniprot_id": [ { "id": "PLCH2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "external" } ], "mass": 164297.0, "length": 1501, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "gene_name": "Plch2", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b", "refseq_ac": [ { "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831", "type": "external" } ], "gene_names_uniprotkb": "Plch2; Plcl4", "gene_names_refseq": "A930027K05Rik; PLCeta2; Plc-eta2; Plch2; Plcl4", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; 3.1.4.11; PLC-L4; PLC-eta2; Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; Phospholipase C-eta-2; Phospholipase C-like protein 4", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; phospholipase C-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:269615); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15345747;15583837;15899900;16107206;17114649;20060933;21183079;21750661;23237262", "class_list": "", "function": "Molecular cloning of PLC-eta1 and PLC-eta2., [RefSeq, PubMed]; PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain, [RefSeq, PubMed]; PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina., [RefSeq, PubMed]; The molecular cloning and sequencing of phospholipase C eta2 are reported., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6PWW5;Q3LUA7;Q4QSC7;Q80WP6;Q8BJV1;Q8BWU4;Q8BXN5;Q8CFR1", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A2AP18-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DFV3-1", "uniprot_id": [ { "id": "RHG21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DFV3", "type": "external" } ], "mass": 215874.0, "length": 1945, "protein_name": "Rho GTPase-activating protein 21", "gene_name": "Arhgap21", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 21 isoform 2", "refseq_ac": [ { "id": "NP_001074833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074833", "type": "external" } ], "gene_names_uniprotkb": "Arhgap21; Arhgap10; Kiaa1424", "gene_names_refseq": "5530401C11Rik; ARHGAP10; Arhgap21", "protein_names_uniprotkb": "Rho GTPase-activating protein 21; Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 21", "protein_names_refseq": "rho GTPase-activating protein 10; rho GTPase-activating protein 21 isoform 2; rho GTPase-activating protein 21; rho-type GTPase-activating protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:71435); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-9696264)", "pathway_count": 13, "publication_count": 17, "publication_id_list": "16452087;17242355;17347647;18299400;19144319;21183079;21750661;21952136;22517741;24129315;25428506;30059200;30084848;32848054;33727037;36852467;40885482", "class_list": "", "function": "Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function., [RefSeq, PubMed]; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AL67;Q80TD7;Q80XS1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030054 cell junction", "go_biological_process": "GO:0051684 maintenance of Golgi location;GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0051683 establishment of Golgi localization;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q6DFV3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62178-1", "uniprot_id": [ { "id": "SEM4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62178", "type": "external" } ], "mass": 83421.0, "length": 760, "protein_name": "Semaphorin-4A", "gene_name": "Sema4a", "organism": "Mouse", "refseq_name": "semaphorin-4A precursor", "refseq_ac": [ { "id": "NP_001156961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156961", "type": "external" } ], "gene_names_uniprotkb": "Sema4a; SemB; Semab", "gene_names_refseq": "SemB; Sema4a; Semab", "protein_names_uniprotkb": "Semaphorin-4A; Sema B; Semaphorin-B", "protein_names_refseq": "sema B; semaphorin-4A precursor; semaphorin-4A; semaphorin-B", "tax_id": 10090, "disease": "retinitis pigmentosa 35 (Disease Ontology:DOID:0110357); cone-rod dystrophy 10 (Disease Ontology:DOID:0111017)", "pathway": " (mmu:20351); (R-MMU-416700)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12374982;15277503;15780988;17242355;17318185;19144319;20043131;21750661;29981480;30084848;30899004;34428180;7748561", "class_list": "", "function": "Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D3Z5L2", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0045063 T-helper 1 cell differentiation;GO:0001525 angiogenesis;GO:0007409 axonogenesis;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q62178-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJI1-1", "uniprot_id": [ { "id": "S6A17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJI1", "type": "external" } ], "mass": 81071.0, "length": 727, "protein_name": "Sodium-dependent neutral amino acid transporter SLC6A17", "gene_name": "Slc6a17", "organism": "Mouse", "refseq_name": "sodium-dependent neutral amino acid transporter SLC6A17 isoform 1", "refseq_ac": [ { "id": "NP_001280618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280618", "type": "external" } ], "gene_names_uniprotkb": "Slc6a17; Ntt4", "gene_names_refseq": "D130012J15Rik; Ntt4; Slc6a17", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17", "protein_names_refseq": "orphan sodium- and chloride-dependent neurotransmitter transporter NTT4; sodium-dependent neutral amino acid transporter SLC6A17 isoform 1; sodium-dependent neutral amino acid transporter SLC6A17", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 48 (Disease Ontology:DOID:0081212)", "pathway": " (mmu:229706)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17114649;18034455;21183079;21750661;25704603;30899004;37440432", "class_list": "", "function": "Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability. Publication Status: Online-Only, [RefSeq, PubMed]; Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RUH5;Q8C057;Q8CGQ9", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0015816 glycine transport;GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0032328 alanine transport;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BJI1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UIA2-1", "uniprot_id": [ { "id": "RHG17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UIA2", "type": "external" } ], "mass": 92202.0, "length": 846, "protein_name": "Rho GTPase-activating protein 17", "gene_name": "Arhgap17", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 17 isoform b", "refseq_ac": [ { "id": "NP_001116112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116112", "type": "external" } ], "gene_names_uniprotkb": "Arhgap17", "gene_names_refseq": "5730403H17Rik; Arhgap17; Nadrin2; Nadrin; Rich1; Wbp15", "protein_names_uniprotkb": "Rho GTPase-activating protein 17; Nadrin; Neuron-associated developmentally-regulated protein; Rho-type GTPase-activating protein 17", "protein_names_refseq": "WW domain-binding protein 15; neuron-associated developmentally regulated protein; rho GTPase-activating protein 17 isoform b; rho GTPase-activating protein 17; rho-type GTPase-activating protein 17", "tax_id": 10090, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:70497); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013423)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10967100;21183079;21750661;26495903;32782141;34428180;36852467;39627609", "class_list": "", "function": "Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDP7;Q8BGD1;Q99LH3;Q99N39;Q99N40", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0017156 calcium-ion regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UIA2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6SEU4-1", "uniprot_id": [ { "id": "SYGP1_MOUSE", "url": "https://www.uniprot.org/uniprot/F6SEU4", "type": "external" } ], "mass": 148238.0, "length": 1340, "protein_name": "Ras/Rap GTPase-activating protein SynGAP", "gene_name": "Syngap1", "organism": "Mouse", "refseq_name": "ras/Rap GTPase-activating protein SynGAP isoform 1", "refseq_ac": [ { "id": "NP_001268420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268420", "type": "external" } ], "gene_names_uniprotkb": "Syngap1", "gene_names_refseq": "Gm1963; Syngap1; Syngap", "protein_names_uniprotkb": "Ras/Rap GTPase-activating protein SynGAP; Neuronal RasGAP; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1", "protein_names_refseq": "neuronal RasGAP; ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP isoform 1; ras/Rap GTPase-activating protein SynGAP; synaptic Ras GTPase-activating protein 1; synaptic Ras-GAP 1", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autosomal dominant intellectual developmental disorder 5 (Disease Ontology:DOID:0070035); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:240057); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;16452087;16452088;18034455;20485683;21183079;21750661;22645316;22692543;27565345;28657654;32848054;33300544;34428180;34678516;35822049;38452102;40021952;40885482", "class_list": "", "function": "Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity)., [UniProtKB]; Overexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and increasing miniature excitatory synaptic currents amplitude/frequency, respectively. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 27, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 27, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 27, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 28, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0043198 dendritic shaft", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0008542 visual learning;GO:0016358 dendrite development;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0050803 regulation of synapse structure or activity", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "F6SEU4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8Q8-1", "uniprot_id": [ { "id": "SACA6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8Q8", "type": "external" } ], "mass": 38503.0, "length": 339, "protein_name": "Sperm acrosome membrane-associated protein 6", "gene_name": "Spaca6", "organism": "Mouse", "refseq_name": "sperm acrosome membrane-associated protein 6 precursor", "refseq_ac": [ { "id": "NP_001156381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156381", "type": "external" } ], "gene_names_uniprotkb": "Spaca6; 4930546H06Rik; Ncrna00085", "gene_names_refseq": "4930546H06Rik; 9530079D04Rik; B230206P06Rik; Ncrna00085; SPACA6A; Spaca6; let-7e; mir-125a; mir-99b", "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 6", "protein_names_refseq": "immunoglobulin domain-containing protein; sperm acrosome membrane-associated protein 6 precursor; sperm acrosome membrane-associated protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:75202)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;24275887;25059272;28533542;32210282;32393636;33599498;34775219;38528182", "class_list": "", "function": "Dual-luciferase reporter gene analysis showed that RTEF-1 is a direct target of mir-125a-5p, which regulates angiogenesis by repressing RTEF-1 expression and modulating eNOS and VEGF expression., [RefSeq, PubMed]; Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function., [RefSeq, PubMed]; MiR-99b-5p Attenuates Adipogenesis by Targeting SCD1 and Lpin1 in 3T3-L1 Cells., [RefSeq, PubMed]; Our findings suggest a mechanism, by which a decrease in miR-125a-3p during oocyte maturation facilitates GVBD by allowing Fyn up-regulation and the resulting stabilization of the interaction between actin and A-type lamins. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice., [RefSeq, PubMed]; Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion. Publication Status: Online-Only, [RefSeq, PubMed]; Sperm protein required for fusion of sperm with the egg membrane during fertilization (PubMed:24275887, PubMed:32210282, PubMed:32393636). May regulate the expression of sperm surface protein DCST2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; The Spaca6 gene product may, together with Izumo1, mediate sperm fusion by binding an as yet unidentified egg membrane receptor., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZWC7;D3Z1S3;J3QMI7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9Q8Q8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JB8-1", "uniprot_id": [ { "id": "PACN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JB8", "type": "external" } ], "mass": 48585.0, "length": 424, "protein_name": "Protein kinase C and casein kinase II substrate protein 3", "gene_name": "Pacsin3", "organism": "Mouse", "refseq_name": "protein kinase C and casein kinase II substrate protein 3", "refseq_ac": [ { "id": "NP_001276606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276606", "type": "external" } ], "gene_names_uniprotkb": "Pacsin3", "gene_names_refseq": "4921507A02Rik; 6330413E15Rik; Pacsin3", "protein_names_uniprotkb": "Protein kinase C and casein kinase II substrate protein 3", "protein_names_refseq": "protein kinase C and casein kinase II substrate protein 3", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:80708); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11082044;11179684;16627472;17242355;17320047;18174177;19131326;21183079;21750661;22573331;24500282;29202928;34428180;36288343", "class_list": "", "function": "PACSIN 3 specifically affects the endocytosis of TRPV4, thereby modulating the subcellular localization, [RefSeq, PubMed]; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Show that in neuroendocrine chromaffin cells fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3., [RefSeq, PubMed]; The authors show that muscle cells of syndapin III knockout mice show severe reductions of caveolae reminiscent of human caveolinopathies. The membrane-shaping protein syndapin III is crucial for caveolar invagination and gene knockout rendered the cells sensitive to membrane tensions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQP9", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0008092 cytoskeletal protein binding;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99JB8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TWL2-1", "uniprot_id": [ { "id": "PP4P1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TWL2", "type": "external" } ], "mass": 30047.0, "length": 284, "protein_name": "Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "gene_name": "Pip4p1", "organism": "Mouse", "refseq_name": "type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1", "refseq_ac": [ { "id": "NP_001028443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028443", "type": "external" } ], "gene_names_uniprotkb": "Pip4p1; Tmem55b", "gene_names_refseq": "Pip4p1; Tmem55b", "protein_names_uniprotkb": "Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; 3.1.3.78; PtdIns-4,5-P2 4-Ptase I; Transmembrane protein 55B; Type 1 PtdIns-4,5-P2 4-Ptase", "protein_names_refseq": "PtdIns-4,5-P(2) 4-phosphatase type I; ptdIns-4,5-P2 4-Ptase I; transmembrane protein 55b; type 1 PtdIns-4,5-P2 4-Ptase; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:219024); (R-MMU-6811555); (R-MMU-8847453)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19144319;21750661;29644770;31329883;37961834", "class_list": "", "function": "Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease., [RefSeq, PubMed]; The TMEM55B has been implicated in starvation induced lysosomal translocation. Amino acid starvation induces perinuclear lamp1 clustering in RAW264.7 macrophages, which was attenuated by shRNA-mediated knock-down or CRISPR/Cas9-mediated knock-out of TMEM55B., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.78", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.78", "type": "external" } ], "go_molecular_function": "GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0008203 cholesterol metabolic process;GO:0032418 lysosome localization;GO:0046856 phosphatidylinositol dephosphorylation;GO:0006991 response to sterol depletion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TWL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESJ4-1", "uniprot_id": [ { "id": "SPN90_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESJ4", "type": "external" } ], "mass": 78572.0, "length": 714, "protein_name": "NCK-interacting protein with SH3 domain", "gene_name": "Nckipsd", "organism": "Mouse", "refseq_name": "NCK-interacting protein with SH3 domain", "refseq_ac": [ { "id": "NP_109654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109654", "type": "external" } ], "gene_names_uniprotkb": "Nckipsd; Spin90; Wasbp", "gene_names_refseq": "AF3P21; DIP1; Nckipsd; ORF1; SPIN90; WASLBP; WISH; Wasbp", "protein_names_uniprotkb": "NCK-interacting protein with SH3 domain; 54 kDa VacA-interacting protein; 90 kDa N-WASP-interacting protein; 90 kDa SH3 protein interacting with Nck; N-WASP-binding protein; SH3 adapter protein SPIN90; VIP54; WASP-interacting SH3-domain protein; WISH; Wiskott-Aldrich syndrome protein-binding protein", "protein_names_refseq": "54 kDa VacA-interacting protein; 90 kDa N-WASP-interacting protein; 90 kDa SH3 protein interacting with Nck; N-WASP-binding protein; NCK-interacting protein with SH3 domain; SH3 adapter protein SPIN90; VIP54; WASP-interacting SH3-domain protein; Wiskott-Aldrich syndrome homolog binding protein; mDia interacting protein-1; wiskott-Aldrich syndrome protein-binding protein WISH", "tax_id": 10090, "disease": "", "pathway": " (mmu:80987); (R-MMU-2029482); (R-MMU-5663213)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10619843;11157975;18234668;21183079;21750661;22645316;28652253;30341913;33300544;34428180;36142484;40885482", "class_list": "", "function": "Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) (By similarity). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomere and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion., [UniProtKB]; Identification of a new interaction between Nef and diaphanous interacting protein (DIP), a recently described regulator of Rho and Rac signaling, [RefSeq, PubMed]; Low SPIN90 expression is associated with Breast Cancer., [RefSeq, PubMed]; SPIN90 Deficiency Ameliorates Amyloid beta Accumulation by Regulating APP Trafficking in AD Model Mice. Publication Status: Online-Only, [RefSeq, PubMed]; SPIN90 depletion activates FAK/ROCK signaling, induced by Postn expression, which is critical for myofibroblastic differentiation on soft matrices mimicking the mechanical environment of a normal tissue., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYF3;Q68G72", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0006897 endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ESJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLC8-1", "uniprot_id": [ { "id": "SACS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLC8", "type": "external" } ], "mass": 520685.0, "length": 4582, "protein_name": "Sacsin", "gene_name": "Sacs", "organism": "Mouse", "refseq_name": "sacsin isoform 2", "refseq_ac": [ { "id": "NP_766397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766397", "type": "external" } ], "gene_names_uniprotkb": "Sacs; Dnajc29; Kiaa0730", "gene_names_refseq": "A230052M14; DNAJC29; E130115J16Rik; Sacs", "protein_names_uniprotkb": "Sacsin; DnaJ homolog subfamily C member 29", "protein_names_refseq": "dnaJ homolog subfamily C member 29; sacsin isoform 2", "tax_id": 10090, "disease": "Charlevoix-Saguenay spastic ataxia (Disease Ontology:DOID:0050946)", "pathway": " (mmu:50720)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10655055;17114649;19208651;21183079;21750661;25260547;30016717;30866998;30899004;31219806;31599954;35820727;39627609", "class_list": "", "function": "Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins., [UniProtKB, UniProtKB, UniProtKB]; Results indicate that the Sacs-/- mouse is a well-suited rodent model of the human condition and suggest that disruption of mitochondria organization and positioning cause autosomal recessive spastic ataxia of Charlevoix-Saguenay pathology., [RefSeq, PubMed]; Sacs missense mutation largely lead to loss of sacsin function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUF2;Q6A007;Q8BQT3;Q8C764;Q8CAJ4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051087 protein-folding chaperone binding;GO:0070628 proteasome binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9JLC8-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTY2-1", "uniprot_id": [ { "id": "S4A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTY2", "type": "external" } ], "mass": 116514.0, "length": 1034, "protein_name": "Sodium bicarbonate cotransporter 3", "gene_name": "Slc4a7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc4a7; Nbc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium bicarbonate cotransporter 3; Solute carrier family 4 member 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "Usher syndrome type 2C (Disease Ontology:DOID:0110839); anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:218756); (R-MMU-425381); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9035034)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12403779;12808454;16301216;16439691;17242355;17928512;19131326;19144319;19349973;21183079;21750661;22586225;23401617;31219806;33321164;34428180;35820727;37828378", "class_list": "", "function": "Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:16439691, PubMed:22586225, PubMed:23401617). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (PubMed:16439691, PubMed:22586225, PubMed:23401617). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (By similarity). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (By similarity). May be involved in maintaining locomotor activity, exploratory behavior, and hearing (PubMed:12808454, PubMed:33321164)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5H7", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0090383 phagosome acidification;GO:0055085 transmembrane transport;GO:0007601 visual perception;GO:0071363 cellular response to growth factor stimulus;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8BTY2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8N2-1", "uniprot_id": [ { "id": "SCAI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8N2", "type": "external" } ], "mass": 70275.0, "length": 606, "protein_name": "Protein SCAI", "gene_name": "Scai", "organism": "Mouse", "refseq_name": "protein SCAI isoform 1", "refseq_ac": [ { "id": "NP_848893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848893", "type": "external" } ], "gene_names_uniprotkb": "Scai", "gene_names_refseq": "9330112M16; A930041I02Rik; Scai", "protein_names_uniprotkb": "Protein SCAI; Suppressor of cancer cell invasion protein", "protein_names_refseq": "protein SCAI isoform 1; protein SCAI; suppressor of cancer cell invasion protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320271); (R-MMU-5663220)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18034455;19350017;21750661;23178076;27820601;31219806;33300544;34428180;34597596", "class_list": "", "function": "SCAI (suppressor of cancer cell invasion) is identified as a 53BP1-interacting chromatin-associated protein that promotes the functionality of several DNA double-strand breaks repair pathways in mammalian cells., [RefSeq, PubMed]; SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis., [RefSeq, PubMed]; The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair., [RefSeq, PubMed]; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTF5;A3KGQ2;Q8C409;Q8C8K2", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030336 negative regulation of cell migration;GO:0035024 negative regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C8N2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54834-1", "uniprot_id": [ { "id": "RHG06_MOUSE", "url": "https://www.uniprot.org/uniprot/O54834", "type": "external" } ], "mass": 108844.0, "length": 987, "protein_name": "Rho GTPase-activating protein 6", "gene_name": "Arhgap6", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 6 isoform c", "refseq_ac": [ { "id": "NP_001274459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274459", "type": "external" } ], "gene_names_uniprotkb": "Arhgap6", "gene_names_refseq": "Arhgap6; RhoGAPX-1", "protein_names_uniprotkb": "Rho GTPase-activating protein 6; Rho-type GTPase-activating protein 6; Rho-type GTPase-activating protein RhoGAPX-1", "protein_names_refseq": "rho GTPase-activating protein 6 isoform c; rho GTPase-activating protein 6; rho-type GTPase-activating protein 6; rho-type GTPase-activating protein RhoGAPX-1", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:11856); (R-MMU-8980692); (R-MMU-9013423)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10699171;11668396;17242355;21183079;21750661;9417914", "class_list": "", "function": "Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice, [RefSeq, PubMed]; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ABW4;A2AC55;Q3TMC2;Q8BG83;Q8C842;Q9QZL8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0016004 phospholipase activator activity;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0072686 mitotic spindle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0048041 focal adhesion assembly;GO:0051895 negative regulation of focal adhesion assembly;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54834-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FL4-1", "uniprot_id": [ { "id": "SAHH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FL4", "type": "external" } ], "mass": 66899.0, "length": 613, "protein_name": "S-adenosylhomocysteine hydrolase-like protein 2", "gene_name": "Ahcyl2", "organism": "Mouse", "refseq_name": "putative adenosylhomocysteinase 3 isoform 2", "refseq_ac": [ { "id": "NP_001164471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164471", "type": "external" } ], "gene_names_uniprotkb": "Ahcyl2", "gene_names_refseq": "4631427C17Rik; Adohcyase3; Ahcyl2; mKIAA0828", "protein_names_uniprotkb": "S-adenosylhomocysteine hydrolase-like protein 2; Long-IRBIT", "protein_names_refseq": "S-adenosyl-L-homocysteine hydrolase 3; S-adenosylhomocysteine hydrolase-like protein 2; clone MNCb-5555; long-IRBIT; putative adenosylhomocysteinase 3 isoform 2; putative adenosylhomocysteinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74340); (R-MMU-425381)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17114649;19220705;21183079;21750661;25428506;26495903;27382360;28348216;34887587;36210013;37828378", "class_list": "", "function": "Long-Irbit splice variants have different N-terminal sequences and a common C-terminal region, which is involved in multimerization of IRBIT and Long-IRBIT.N-terminal splicing of Long-IRBIT changed the protein stability., [RefSeq, PubMed]; Regulatory protein that interacts with and modulates the activity of membrane ion transporters, including the sodium-bicarbonate cotransporter SLC4A4, through phosphorylation-dependent binding. Functions as a homolog of AHCYL1 to regulate bicarbonate transport and intracellular pH homeostasis via direct interactions rather than enzymatic activity (PubMed:27382360). On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIH1", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle;GO:0043005 neuron projection", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0033353 S-adenosylmethionine cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q68FL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VGL6-1", "uniprot_id": [ { "id": "RC3H1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VGL6", "type": "external" } ], "mass": 125378.0, "length": 1130, "protein_name": "Roquin-1", "gene_name": "Rc3h1", "organism": "Mouse", "refseq_name": "roquin-1", "refseq_ac": [ { "id": "NP_001020123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020123", "type": "external" } ], "gene_names_uniprotkb": "Rc3h1; Gm551; Kiaa2025", "gene_names_refseq": "5730557L09Rik; Gm551; Rc3h1; mKIAA2025", "protein_names_uniprotkb": "Roquin-1; 2.3.2.27; Protein Sanroque; RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1; Roquin", "protein_names_refseq": "RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1; probable E3 ubiquitin-protein ligase Roquin; protein Sanroque; roquin-1; roquin", "tax_id": 10090, "disease": "peripheral T-cell lymphoma (Disease Ontology:DOID:0050749); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:381305)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;15917799;17242355;18172933;20412057;20639877;21183079;21750661;21844204;23451046;23550652;23583642;23583643;23663784;25026077;25282160;25697406;26000482;27010430;29244194;30084848;31636267;32782141;34428180;34811541;34879274;35820727;37988467", "class_list": "", "function": "Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses., [RefSeq, PubMed]; Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity., [RefSeq, PubMed]; Negative regulator of follicular helper T cells. Represses ICOS expression on T cells., [RefSeq, PubMed]; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:18172933, PubMed:23663784, PubMed:25026077). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (PubMed:26000482). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (PubMed:20412057, PubMed:20639877). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (PubMed:15917799, PubMed:23583642, PubMed:23583643). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (PubMed:27010430). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (PubMed:29244194). Able to interact with double-stranded RNA (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 25, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RS13;Q69Z31", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0002635 negative regulation of germinal center formation;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0045623 negative regulation of T-helper cell differentiation;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q4VGL6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61206-1", "uniprot_id": [ { "id": "PA1B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61206", "type": "external" } ], "mass": 25581.0, "length": 229, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha2", "gene_name": "Pafah1b2", "organism": "Mouse", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d", "refseq_ac": [ { "id": "NP_032801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032801", "type": "external" } ], "gene_names_uniprotkb": "Pafah1b2; Pafahb", "gene_names_refseq": "2610005M20Rik; Pafah1b2; Pafahb; mus[b]", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha2; 3.1.1.47; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta", "protein_names_refseq": "PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha2; PAF-AH subunit beta; platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d; platelet-activating factor acetylhydrolase IB subunit alpha2; platelet-activating factor acetylhydrolase IB subunit beta", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:18475); (R-MMU-6798695); (R-MMU-6811436)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12775763;17330141;19272360;21183079;21750661;23238734;28135057;34428180;8954729", "class_list": "", "function": "Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (PubMed:12775763)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Knockdown of PAFAH1B2 strongly reduced Abeta secretion from human cells, and this effect was confirmed in primary cells derived from PAFAH1B2 knock-out mice, [RefSeq, PubMed]; Study examined biochemical interactions of Pafah1b Alpha1 & Alpha2 subunits with the Reelin signaling machinery & demonstrated that Alpha2, but not Alpha1, binds Dab1 in a phosphorylation-independent manner, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PKE6;Q7TNP3", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61206-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQH0-1", "uniprot_id": [ { "id": "PDZ1I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQH0", "type": "external" } ], "mass": 12298.0, "length": 114, "protein_name": "PDZK1-interacting protein 1", "gene_name": "Pdzk1ip1", "organism": "Mouse", "refseq_name": "PDZK1-interacting protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001158029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158029", "type": "external" } ], "gene_names_uniprotkb": "Pdzk1ip1; Map17", "gene_names_refseq": "0610007F13Rik; 2700030M23Rik; Map17; Pdzk1ip1", "protein_names_uniprotkb": "PDZK1-interacting protein 1; 17 kDa membrane-associated protein", "protein_names_refseq": "17 kDa membrane-associated protein; PDZK1-interacting protein 1 isoform 1; membrane-associated protein 17 (Map17)", "tax_id": 10090, "disease": "", "pathway": " (mmu:67182)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12754212;12837682;18931049;19710538;21183079;21750661;30718277;34428180", "class_list": "", "function": "Auxiliary protein of electrogenic Na(+)-coupled sugar symporter SLC5A2/SGLT2 and SLC5A1/SGLT1 (By similarity). Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1 (By similarity)., [UniProtKB, UniProtKB]; Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show that NHERF1 is essential for both normal and mutant CFTR function [review] Review article, [RefSeq, PubMed]; MAP17 1) interacts with PDZK1 only, 2) associates with the NH2 terminus of NaPi-IIa within the PDZK1/NaPi-IIa/MAP17 complex, and 3) acts as an apical anchoring site for PDZK1., [RefSeq, PubMed]; Membrane associated protein 17 may be an endogenous regulator of cellular PDZ domain containing 1(PDZK1) levels by regulating PDZK1 turnover, [RefSeq, PubMed]; Systematic analysis of Pdzk1ip1 is reported., [RefSeq, PubMed]; These findings indicate that PDZK1IP1 interacts with Smad4 and thereby suppresses the TGF-beta signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88502-1", "uniprot_id": [ { "id": "PDE8A_MOUSE", "url": "https://www.uniprot.org/uniprot/O88502", "type": "external" } ], "mass": 93171.0, "length": 823, "protein_name": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A", "gene_name": "Pde8a", "organism": "Mouse", "refseq_name": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A", "refseq_ac": [ { "id": "NP_032829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032829", "type": "external" } ], "gene_names_uniprotkb": "Pde8a; Pde8", "gene_names_refseq": "Pde8a; Pde8", "protein_names_uniprotkb": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; 3.1.4.53; MmPDE8", "protein_names_refseq": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A", "tax_id": 10090, "disease": "", "pathway": " (mmu:18584); (R-MMU-418555)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17172443;19144319;21183079;23509299;28851628;38506047;38782837;40885482;9671792", "class_list": "", "function": "AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction., [RefSeq, PubMed]; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine., [UniProtKB, UniProtKB]; Our studies demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation, [RefSeq, PubMed]; Pharmacological manipulation of PDE8A, alone or in combination with other PDEs present in Leydig cells, may be exploited to modulate testosterone synthesis, [RefSeq, PubMed]; Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer's Disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059P6", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0019900 kinase binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88502-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09411-1", "uniprot_id": [ { "id": "PGK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P09411", "type": "external" } ], "mass": 44550.0, "length": 417, "protein_name": "Phosphoglycerate kinase 1", "gene_name": "Pgk1", "organism": "Mouse", "refseq_name": "phosphoglycerate kinase 1", "refseq_ac": [ { "id": "NP_032854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032854", "type": "external" } ], "gene_names_uniprotkb": "Pgk1; Pgk-1", "gene_names_refseq": "Pgk-1; Pgk1", "protein_names_uniprotkb": "Phosphoglycerate kinase 1; 2.7.11.1; 2.7.2.3", "protein_names_refseq": "phosphoglycerate kinase 1", "tax_id": 10090, "disease": "phosphoglycerate kinase 1 deficiency (Disease Ontology:DOID:0111933); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (mmu:18655); (R-MMU-165159); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 4, "publication_count": 34, "publication_id_list": "11130727;11801660;16075062;16393994;17242355;18034455;19131326;1975492;19759366;21183079;2166582;21750661;23806337;25428506;25605945;26740625;27802388;29237092;30084848;31219806;33300544;33649389;33725478;3440520;34428180;3525226;3542714;35984892;36288343;37453647;37507081;37828378;39080660;39927985", "class_list": "glycogene", "function": "Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility., [UniProtKB, UniProtKB]; Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphoglycerate kinase is a moonlighting protein that functions as both a glycolytic enzyme and a disulfide reductase., [RefSeq, PubMed]; The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPE6;Q3UKV8;Q5XJE7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004618 phosphoglycerate kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0071456 cellular response to hypoxia;GO:0006094 gluconeogenesis;GO:0016525 negative regulation of angiogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P09411-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12815-1", "uniprot_id": [ { "id": "PDCD6_MOUSE", "url": "https://www.uniprot.org/uniprot/P12815", "type": "external" } ], "mass": 21867.0, "length": 191, "protein_name": "Programmed cell death protein 6", "gene_name": "Pdcd6", "organism": "Mouse", "refseq_name": "programmed cell death protein 6 isoform 1", "refseq_ac": [ { "id": "NP_035181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035181", "type": "external" } ], "gene_names_uniprotkb": "Pdcd6; Alg2", "gene_names_refseq": "Alg2; MA-3; PS2; Pdcd6; alg-2", "protein_names_uniprotkb": "Programmed cell death protein 6; ALG-257; ALG-2; Apoptosis-linked gene 2 protein; PMP41", "protein_names_refseq": "ALG-257; PMP41; apoptosis-linked gene 2 protein; probable calcium-binding protein ALG-2; programmed cell death protein 6 isoform 1; programmed cell death protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18570)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10200558;10744743;11525164;12024023;12522145;17889823;2736249;27541325;28300556;30501057;31219806;34762908;37453647;8560270", "class_list": "", "function": "ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling., [RefSeq, PubMed]; ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity., [RefSeq, PubMed]; Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (PubMed:10744743, PubMed:11525164, PubMed:27541325). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (PubMed:8560270). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (PubMed:12024023). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Has a lower Ca(2+) affinity than isoform 1 (PubMed:10744743)., [UniProtKB, PubMed]; Results provide a better understanding of the target recognition mechanism and conformational change of SOUL in the interaction with ALG-2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545I0;Q61145", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0014029 neural crest formation;GO:0001525 angiogenesis;GO:0006886 intracellular protein transport;GO:0043065 positive regulation of apoptotic process;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P12815-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70271-1", "uniprot_id": [ { "id": "PDLI4_MOUSE", "url": "https://www.uniprot.org/uniprot/P70271", "type": "external" } ], "mass": 35556.0, "length": 330, "protein_name": "PDZ and LIM domain protein 4", "gene_name": "Pdlim4", "organism": "Mouse", "refseq_name": "PDZ and LIM domain protein 4 isoform 1", "refseq_ac": [ { "id": "NP_062290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062290", "type": "external" } ], "gene_names_uniprotkb": "Pdlim4; Ril", "gene_names_refseq": "Pdlim4; Ril", "protein_names_uniprotkb": "PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein", "protein_names_refseq": "LIM protein RIL; PDZ and LIM domain protein 4 isoform 1; PDZ and LIM domain protein 4; reversion induced LIM; reversion-induced LIM protein", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (mmu:30794)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10826496;14729062;15663004;16452087;17242355;21183079;21750661;25428506;31287961;31393857;9487134", "class_list": "", "function": "Findings have identified Pdlim4 as a JMJD3 target gene that affects T-cell trafficking by cooperating with S1P1, and provided insights into the molecular mechanisms by which JMJD3 regulates genes involved in T cell trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; Pdlim4 is required for dendritic cell migration via CCR7-JNK, dendrite formation, and subsequent development of functional T-cell responses., [RefSeq, PubMed]; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWV2;Q8K0W4", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034777 recycling endosome lumen;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70271-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61823-1", "uniprot_id": [ { "id": "PDCD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61823", "type": "external" } ], "mass": 51702.0, "length": 469, "protein_name": "Programmed cell death protein 4", "gene_name": "Pdcd4", "organism": "Mouse", "refseq_name": "programmed cell death protein 4", "refseq_ac": [ { "id": "NP_001161963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161963", "type": "external" } ], "gene_names_uniprotkb": "Pdcd4; Ma3; Tis", "gene_names_refseq": "D19Ucla1; Ma3; Pdcd4; Tis", "protein_names_uniprotkb": "Programmed cell death protein 4; Protein MA-3; Topoisomerase-inhibitor suppressed protein", "protein_names_refseq": "programmed cell death protein 4; protein MA-3; topoisomerase-inhibitor suppressed protein", "tax_id": 10090, "disease": "skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:18569)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "12482958;12894233;16024603;16682971;17060447;17310995;19153607;21183079;21750661;26495903;28644433;34203471;34428180;36210013;38293973;38324980;38503934;38723677;38822367;39627609;8543179;8912629;9714845", "class_list": "", "function": "Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4. Publication Status: Online-Only, [RefSeq, PubMed]; Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARgamma/IL-10 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency., [RefSeq, PubMed]; Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression., [RefSeq, PubMed]; [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97296;Q3T9A9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:1904761 negative regulation of myofibroblast differentiation;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q61823-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62048-1", "uniprot_id": [ { "id": "PEA15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62048", "type": "external" } ], "mass": 15054.0, "length": 130, "protein_name": "Astrocytic phosphoprotein PEA-15", "gene_name": "Pea15a; Pea15", "organism": "Mouse", "refseq_name": "astrocytic phosphoprotein PEA-15 isoform 2", "refseq_ac": [ { "id": "NP_001316798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316798", "type": "external" } ], "gene_names_uniprotkb": "Pea15a; Pea15; Pea15a", "gene_names_refseq": "Mat1; PEA-15; Pea15a; Pea15; Pkcs15", "protein_names_uniprotkb": "Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes", "protein_names_refseq": "15 kDa phosphoprotein enriched in astrocytes; astrocytic phosphoprotein PEA-15 isoform 2; astrocytic phosphoprotein PEA-15; mammary transforming gene 1; phosphoprotein enriched in astrocytes 15A; phosphoprotein enriched in astrocytes 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:18611); (R-MMU-112409); (R-MMU-5673001)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10588860;10926929;11210189;19131326;19917132;21183079;21750661;27426254;31219806;33772049;34428180;36210013;8662970", "class_list": "", "function": "Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity)., [UniProtKB, PubMed]; Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion. Publication Status: Online-Only, [RefSeq, PubMed]; The neurological and neurochemical phenotype of transgenic mice overexpressing PED/PEA-15 (tgPED), were analyzed. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]., [RefSeq]; We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5N7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005875 microtubule associated complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0000165 MAPK cascade;GO:0006915 apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0046325 negative regulation of D-glucose import;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62048-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHR5-1", "uniprot_id": [ { "id": "P66B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHR5", "type": "external" } ], "mass": 65411.0, "length": 594, "protein_name": "Transcriptional repressor p66-beta", "gene_name": "Gatad2b", "organism": "Mouse", "refseq_name": "transcriptional repressor p66-beta isoform a", "refseq_ac": [ { "id": "NP_647465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647465", "type": "external" } ], "gene_names_uniprotkb": "Gatad2b", "gene_names_refseq": "C430014D17Rik; Gatad2b; P66beta; mKIAA1150", "protein_names_uniprotkb": "Transcriptional repressor p66-beta; GATA zinc finger domain-containing protein 2B; p66/p68", "protein_names_refseq": "GATA zinc finger domain-containing protein 2B; p66/p68; transcription repressor p66 beta component of the MeCP1 complex; transcription repressor p66 component of the MeCP1 complex; transcriptional repressor p66-beta isoform a; transcriptional repressor p66-beta", "tax_id": 10090, "disease": "GAND syndrome (Disease Ontology:DOID:0070048); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:229542); (R-MMU-3214815); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 7, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;11756549;15345747;17242355;19144319;21183079;21606357;21750661;22645316;25428506;29237092;30013058;30059200;30084848;31219806;31599954;32782141;32848054;34428180;35822049;36852467;38238293;38605678;40021952;40885482;40997131", "class_list": "", "function": "GATAD2B interacts with C-MYC to enhance KRAS driven tumor growth. Publication Status: Online-Only, [RefSeq, PubMed]; GATAD2B is required for pre-implantation embryonic development by regulating zygotic genome activation., [RefSeq, PubMed]; Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9Q3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000781 chromosome, telomeric region;GO:0016581 NuRD complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q8VHR5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922H2-1", "uniprot_id": [ { "id": "PDK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922H2", "type": "external" } ], "mass": 47923.0, "length": 415, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "gene_name": "Pdk3", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase kinase, isozyme 3", "refseq_ac": [ { "id": "NP_663605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663605", "type": "external" } ], "gene_names_uniprotkb": "Pdk3", "gene_names_refseq": "2610001M10Rik; Pdk3", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; 2.7.11.2; Pyruvate dehydrogenase kinase isoform 3", "protein_names_refseq": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; pyruvate dehydrogenase kinase, isozyme 3", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease X-linked dominant 6 (Disease Ontology:DOID:0110207)", "pathway": " (mmu:236900); (R-MMU-204174); (R-MMU-5362517)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "23806337;25991547;27388934;33300544;35820727;39399421", "class_list": "", "function": "Demonstrate that the increased PDK3 activity in patient fibroblasts (PDK3(R158H)) leads to the attenuation of PDC through hyper-phosphorylation of E1 at selected serine residues, [RefSeq, PubMed]; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity)., [UniProtKB]; Pdk3's role in RANKL-induced osteoclast differentiation: insights from a bone marrow macrophage model. Publication Status: Online-Only, [RefSeq, PubMed]; These findings reveal that there are divergent roles of PDKs during oocyte maturation and indicate a new mechanism controlling meiotic structure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTX1", "ec_number_list": [ { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0010906 regulation of glucose metabolic process;GO:2000377 regulation of reactive oxygen species metabolic process;GO:0018105 peptidyl-serine phosphorylation;GO:0035357 peroxisome proliferator activated receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q922H2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0L6-1", "uniprot_id": [ { "id": "PCM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0L6", "type": "external" } ], "mass": 228847.0, "length": 2025, "protein_name": "Pericentriolar material 1 protein", "gene_name": "Pcm1", "organism": "Mouse", "refseq_name": "pericentriolar material 1 protein isoform 4", "refseq_ac": [ { "id": "NP_076151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076151", "type": "external" } ], "gene_names_uniprotkb": "Pcm1", "gene_names_refseq": "2600002H09Rik; 9430077F19Rik; C030044G17Rik; Pcm1", "protein_names_uniprotkb": "Pericentriolar material 1 protein; PCM-1; mPCM-1", "protein_names_refseq": "PCM-1; mPCM-1; pericentriolar material 1 protein isoform 4; pericentriolar material 1 protein; pericentriolar material gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18536); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10579718;12112146;12403812;12571289;15107855;15345747;17242355;17705300;19131326;19144319;20173027;21183079;21750661;24356449;24469809;26495903;26643951;27979967;30059200;30779550;31219806;34203471;34428180;34678516;36852467;9680377", "class_list": "", "function": "Required for centrosome assembly and function (PubMed:12112146). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (By similarity). Required to anchor microtubules to the centrosome (By similarity). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results identify a novel role for PCM- 1 in cell cycle regulation, and indicate that PCM-1 must fulfill an essential function for cells to complete interphase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9QLK2;O70287;Q3URH6;Q7TMS7;Q8C9V2;Q91Y27;Q91Y28;Q91Y51;Q923L0;Q9CRK8;Q9CT57", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0001764 neuron migration;GO:0060271 cilium assembly;GO:0035176 social behavior;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q9R0L6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJ88-1", "uniprot_id": [ { "id": "PLPL7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJ88", "type": "external" } ], "mass": 150494.0, "length": 1352, "protein_name": "Patatin-like phospholipase domain-containing protein 7", "gene_name": "Pnpla7", "organism": "Mouse", "refseq_name": "patatin-like phospholipase domain-containing protein 7", "refseq_ac": [ { "id": "NP_666363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363", "type": "external" } ], "gene_names_uniprotkb": "Pnpla7", "gene_names_refseq": "E430013P11Rik; Nre; Pnpla7", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 7; 3.1.1.-; 3.1.1.5; NRE; NTE-related esterase; Neuropathy target esterase-related esterase", "protein_names_refseq": "NTE-related esterase; neuropathy target esterase-related esterase; patatin-like phospholipase domain-containing protein 7", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:241274)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18086666;21183079;21750661;22326266;28887301;31219806;31599954;32103509;34428180;35820727;36719796;36979406", "class_list": "", "function": "Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups., [RefSeq, PubMed]; Lacks lysophospholipase activity., [UniProtKB, PubMed]; Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine (PubMed:18086666, PubMed:28887301). Can also deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0) (PubMed:18086666, PubMed:22326266, PubMed:28887301)., [UniProtKB, PubMed, PubMed, PubMed]; Lysophospholipase., [UniProtKB, PubMed]; The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9YTK0;B0LS74;B0ZTC6;B9EJ75;Q3TD21;Q3UFP1;Q66JS2;Q6P3F9;Q8BTY7;Q8R064;Q8R3C5", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "A2AJ88-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35954-1", "uniprot_id": [ { "id": "PITM1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35954", "type": "external" } ], "mass": 134940.0, "length": 1243, "protein_name": "Membrane-associated phosphatidylinositol transfer protein 1", "gene_name": "Pitpnm1", "organism": "Mouse", "refseq_name": "membrane-associated phosphatidylinositol transfer protein 1", "refseq_ac": [ { "id": "NP_032877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032877", "type": "external" } ], "gene_names_uniprotkb": "Pitpnm1; Dres9; Mpt1; Nir2; Pitpnm", "gene_names_refseq": "DRES9; Mpt-1; Nir-2; PITPnm 1; Pitpnm1; Pitpnm; Rd9; RdgB1; RdgB", "protein_names_uniprotkb": "Membrane-associated phosphatidylinositol transfer protein 1; Drosophila retinal degeneration B homolog 1; Mpt-1; NIR-2; PITPnm 1; Phosphatidylinositol transfer protein, membrane-associated 1; Pyk2 N-terminal domain-interacting receptor 2; RdgB1", "protein_names_refseq": "drosophila retinal degeneration B homolog 1; membrane-associated phosphatidylinositol transfer protein 1; pyk2 N-terminal domain-interacting receptor 2; retinal degeneration 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:18739); (R-MMU-1483226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10400687;21183079;21750661;22645316;24129315;25179602;31219806;31594866;34428180;34678516;40885482;41129229;9245688;9680295", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol (PI) between membranes (By similarity). Binds PI (PubMed:10400687). Also binds phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (By similarity). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (By similarity). Necessary for normal completion of cytokinesis (By similarity). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (By similarity). Required for protein export from the endoplasmic reticulum and the Golgi (By similarity). Binds calcium ions (By similarity)., [UniProtKB, PubMed, UniProtKB]; Membrane-associated phosphatidylinositol (PI) transfer protein that shuttles PI between intracellular membranes and thereby maintains plasma-membrane phosphoinositide signaling competence. Transfers phosphatidylinositol from the endoplasmic reticulum to the plasma membrane and mediates counter-transport of phosphatidic acid (PA) from the plasma membrane to the endoplasmic reticulum at endoplasmic reticulum-plasma membrane contact sites, this PI/PA exchange is required for sustained PLC-coupled receptor signaling and for replenishment of plasma membrane phosphoinositide following receptor-induced hydrolysis (PubMed:41129229). Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis (By similarity). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:10400687)., [UniProtKB, PubMed, UniProtKB, PubMed]; Results suggest that Nir2 not only enhances EMT in vitro and breast cancer metastasis in animal models, but also contributes to breast cancer progression in human patients. Erratum:[J Cell Sci. 2019 Mar 7;132(5):jcs227868. doi: 10.1242/jcs.227868. PMID: 30846603], [RefSeq, PubMed]; The VAP-interacting membrane-associated phosphatidylinositol (PtdIns) transfer proteins PYK2 N-terminal domain-interacting receptor 2 (Nir2) and Nir3 specifically associate with Kv2.1 complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0044297 cell body", "go_biological_process": "GO:0015031 protein transport;GO:0015914 phospholipid transport;GO:1902633 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O35954-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCY8-1", "uniprot_id": [ { "id": "PLPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCY8", "type": "external" } ], "mass": 36936.0, "length": 343, "protein_name": "Phospholipid phosphatase-related protein type 2", "gene_name": "Plppr2", "organism": "Mouse", "refseq_name": "phospholipid phosphatase-related protein type 2 isoform 2", "refseq_ac": [ { "id": "NP_001277228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277228", "type": "external" } ], "gene_names_uniprotkb": "Plppr2; Lppr2; Prg4", "gene_names_refseq": "Lppr2; PRG-4; Plppr2", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 2; Inactive phospholipid phosphatase PLPPR2; Lipid phosphate phosphatase-related protein type 2; PRG-4; Plasticity-related gene 4 protein", "protein_names_refseq": "inactive phospholipid phosphatase PLPPR2; lipid phosphate phosphatase-related protein type 2; phospholipid phosphatase-related protein type 2 isoform 2; phospholipid phosphatase-related protein type 2; plasticity-related gene 4 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:235044); (R-MMU-419408)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;14750979;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIE4", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0F9-1", "uniprot_id": [ { "id": "PGM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0F9", "type": "external" } ], "mass": 61418.0, "length": 562, "protein_name": "Phosphoglucomutase-1", "gene_name": "Pgm1", "organism": "Mouse", "refseq_name": "phosphoglucomutase-1 isoform 2", "refseq_ac": [ { "id": "NP_082408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082408", "type": "external" } ], "gene_names_uniprotkb": "Pgm1; Pgm2", "gene_names_refseq": "2610020G18Rik; Pgm-2; Pgm1a; Pgm1; Pgm2", "protein_names_uniprotkb": "Phosphoglucomutase-1; 5.4.2.2; Glucose phosphomutase 1; PGM 1; Phosphoglucomutase-2", "protein_names_refseq": "glucose phosphomutase 1; phosphoglucomutase 2; phosphoglucomutase-1 isoform 2", "tax_id": 10090, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570); endometrial cancer (Disease Ontology:DOID:1380); teratoma (Disease Ontology:DOID:3307)", "pathway": " (mmu:72157); (R-MMU-3322077); (R-MMU-6798695); (R-MMU-70221); (R-MMU-70370)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "17242355;17947660;18034455;18630941;19131326;21183079;21750661;23806337;25428506;31219806;34428180;36288343;37175952;37453647;37507081;39159700;39927985", "class_list": "glycogene", "function": "Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (By similarity). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (By similarity). This enzyme participates in both the breakdown and synthesis of glucose (By similarity)., [UniProtKB, UniProtKB]; In Vitro Skeletal Muscle Model of PGM1 Deficiency Reveals Altered Energy Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGE3;Q922D6", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030018 Z disc;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006006 glucose metabolic process;GO:0005978 glycogen biosynthetic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D0F9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHK4-1", "uniprot_id": [ { "id": "PGTA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHK4", "type": "external" } ], "mass": 64989.0, "length": 567, "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "Rabggta", "organism": "Mouse", "refseq_name": "geranylgeranyl transferase type-2 subunit alpha", "refseq_ac": [ { "id": "NP_062392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062392", "type": "external" } ], "gene_names_uniprotkb": "Rabggta", "gene_names_refseq": "Rabggta; gm", "protein_names_uniprotkb": "Geranylgeranyl transferase type-2 subunit alpha; 2.5.1.60; Geranylgeranyl transferase type II subunit alpha; Rab GG transferase alpha; Rab GGTase alpha; Rab geranyl-geranyltransferase subunit alpha; Rab geranylgeranyltransferase subunit alpha", "protein_names_refseq": "geranylgeranyl transferase type II subunit alpha; geranylgeranyl transferase type-2 subunit alpha; gunmetal; rab GG transferase alpha; rab GGTase alpha; rab geranylgeranyltransferase subunit alpha", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:56187); (R-MMU-6803205); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10737774;21183079;21750661;25428506", "class_list": "", "function": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLX2", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" } ], "go_molecular_function": "GO:0004663 Rab geranylgeranyltransferase activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0018344 protein geranylgeranylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JHK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08849-1", "uniprot_id": [ { "id": "RGS2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08849", "type": "external" } ], "mass": 24294.0, "length": 211, "protein_name": "Regulator of G protein signaling 2", "gene_name": "Rgs2", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 2", "refseq_ac": [ { "id": "NP_033087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033087", "type": "external" } ], "gene_names_uniprotkb": "Rgs2", "gene_names_refseq": "GOS8; Rgs2", "protein_names_uniprotkb": "Regulator of G protein signaling 2; RGS2", "protein_names_refseq": "regulator of G-protein signaling 2", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); hypertension (Disease Ontology:DOID:10763); opioid abuse (Disease Ontology:DOID:11206); bladder disease (Disease Ontology:DOID:365); liver cirrhosis (Disease Ontology:DOID:5082); female stress incontinence (Disease Ontology:DOID:724)", "pathway": " (mmu:19735); (R-MMU-416476)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10779778;14608379;21750661;34428180;9079700", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (PubMed:14608379). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544S7;Q91WX1;Q9JL24", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0048487 beta-tubulin binding;GO:0010855 adenylate cyclase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0071877 regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08849-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KR6-1", "uniprot_id": [ { "id": "RNF34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KR6", "type": "external" } ], "mass": 42030.0, "length": 376, "protein_name": "E3 ubiquitin-protein ligase RNF34", "gene_name": "Rnf34", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF34 isoform 1", "refseq_ac": [ { "id": "NP_085041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085041", "type": "external" } ], "gene_names_uniprotkb": "Rnf34", "gene_names_refseq": "RIFF; Rnf34", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF34; 2.3.2.27; Phafin-1; RING finger protein 34; RING-type E3 ubiquitin transferase RNF34", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF34 isoform 1; E3 ubiquitin-protein ligase RNF34; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34; phafin 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:80751); (R-MMU-6804757); (R-MMU-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;22064484;32782141;32848054;34015492;35822049;40885482", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation., [UniProtKB, UniProtKB, PubMed]; RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV45", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:1901981 phosphatidylinositol phosphate binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070417 cellular response to cold;GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;GO:2000374 regulation of oxygen metabolic process;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99KR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48379-1", "uniprot_id": [ { "id": "RFX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P48379", "type": "external" } ], "mass": 79190.0, "length": 717, "protein_name": "DNA-binding protein RFX2", "gene_name": "Rfx2", "organism": "Mouse", "refseq_name": "DNA-binding protein RFX2 isoform 2", "refseq_ac": [ { "id": "NP_033082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033082", "type": "external" } ], "gene_names_uniprotkb": "Rfx2", "gene_names_refseq": "5430432H19Rik; Rfx2", "protein_names_uniprotkb": "DNA-binding protein RFX2; Regulatory factor X 2", "protein_names_refseq": "DNA-binding protein RFX2 isoform 2; DNA-binding protein RFX2; regulatory factor X 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19725)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15229132;21750661;22233545;22299025;26162102;26248850;26853561;31219806;32725242;8289803", "class_list": "", "function": "Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis., [RefSeq, PubMed]; Transcription factor that acts as a key regulator of spermatogenesis (PubMed:26162102, PubMed:26248850, PubMed:26853561). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (PubMed:26162102, PubMed:26853561). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:15229132, PubMed:26162102). Probably activates transcription of the testis-specific histone gene H1-6 (PubMed:15229132)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXR3", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007286 spermatid development;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48379-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PR54-1", "uniprot_id": [ { "id": "RIF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PR54", "type": "external" } ], "mass": 266228.0, "length": 2419, "protein_name": "Telomere-associated protein RIF1", "gene_name": "Rif1", "organism": "Mouse", "refseq_name": "telomere-associated protein RIF1 isoform a", "refseq_ac": [ { "id": "NP_780447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780447", "type": "external" } ], "gene_names_uniprotkb": "Rif1", "gene_names_refseq": "5730435J01Rik; 6530403D07Rik; D2Ertd145e; Rif1", "protein_names_uniprotkb": "Telomere-associated protein RIF1; Rap1-interacting factor 1 homolog; mRif1", "protein_names_refseq": "Rap1 interacting factor 1 homolog; mRif1; rap1-interacting factor 1 homolog; telomere-associated protein RIF1 isoform a; telomere-associated protein RIF1", "tax_id": 10090, "disease": "", "pathway": " (mmu:51869); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15042697;21183079;21750661;21952136;23306437;23306439;23333305;23333306;31219806;34428180;36971904;38081811", "class_list": "", "function": "Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23306437, PubMed:23306439, PubMed:23333305). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23306437, PubMed:23306439, PubMed:23333305). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23306437, PubMed:23333305). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23306437, PubMed:23333305). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23306439, PubMed:23333305, PubMed:23333306). Promotes NHEJ of dysfunctional telomeres (PubMed:23333305)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; RIF1 regulates early replication timing in murine B cells. Publication Status: Online-Only, [RefSeq, PubMed]; Rif1 Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells., [RefSeq, PubMed]; This is a mouse ortholog of the yeast Rif1 family of telomere-associated proteins identified on the basis of its high expression in primordial germ cells and embryo-derived pluripotent stem cell lines., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6T8D9;Q7TPD8;Q8BTU2;Q8C408;Q9CS77", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0051233 spindle midzone", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0031509 subtelomeric heterochromatin formation;GO:0043247 telomere maintenance in response to DNA damage;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6PR54-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFU3-1", "uniprot_id": [ { "id": "RN214_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFU3", "type": "external" } ], "mass": 73625.0, "length": 668, "protein_name": "RING finger protein 214", "gene_name": "Rnf214", "organism": "Mouse", "refseq_name": "RING finger protein 214 isoform 2", "refseq_ac": [ { "id": "NP_001297768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297768", "type": "external" } ], "gene_names_uniprotkb": "Rnf214", "gene_names_refseq": "D130054N24Rik; Rnf214", "protein_names_uniprotkb": "RING finger protein 214", "protein_names_refseq": "RING finger protein 214 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235315)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWM9;Q6P3A7;Q80VI8;Q8BNZ6;Q8CC56;Q8CCP2;Q8CE92;Q8R5B9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BFU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PG4-1", "uniprot_id": [ { "id": "RGS18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PG4", "type": "external" } ], "mass": 27610.0, "length": 235, "protein_name": "Regulator of G protein signaling 18", "gene_name": "Rgs18", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 18 isoform 1", "refseq_ac": [ { "id": "NP_075019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075019", "type": "external" } ], "gene_names_uniprotkb": "Rgs18", "gene_names_refseq": "Rgs18", "protein_names_uniprotkb": "Regulator of G protein signaling 18; RGS18", "protein_names_refseq": "regulator of G-protein signaling 18 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64214); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11042171;11342430;21183079;25405900;25969426;26407691;26567214;32542378;34428180;37657560", "class_list": "", "function": "A regulatory node involving Galphaq, PLCbeta, and RGS proteins modulates platelet reactivity to critical agonists., [RefSeq, PubMed]; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha., [UniProtKB]; RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival., [RefSeq, PubMed]; RGS18 deficiency markedly shortened bleeding as well as occlusion times (in vivo). Furthermore, RGS18(-/-) platelets displayed hyper-responsiveness with regards to agonist induced aggregation, [RefSeq, PubMed]; Regulated sequestration and release of RGS18 by intracellular binding proteins coordinates activating and inhibitory signaling networks in platelets. Substituting alanine for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex., [RefSeq, PubMed]; These results identify Rgs18 as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99PG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTV7-1", "uniprot_id": [ { "id": "RNF12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTV7", "type": "external" } ], "mass": 66377.0, "length": 600, "protein_name": "E3 ubiquitin-protein ligase RLIM", "gene_name": "Rlim", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RLIM", "refseq_ac": [ { "id": "NP_035406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035406", "type": "external" } ], "gene_names_uniprotkb": "Rlim; Rnf12", "gene_names_refseq": "Ha1r; Rlim1; Rlim; Rnf12", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RLIM; 2.3.2.27; LIM domain-interacting RING finger protein; R-LIM; RING finger LIM domain-binding protein; RING finger protein 12; RING-type E3 ubiquitin transferase RLIM", "protein_names_refseq": "E3 ubiquitin-protein ligase RLIM; Hoxa1 regulated; LIM domain-interacting RING finger protein; RING finger LIM domain-binding protein; RING-type E3 ubiquitin transferase RLIM; ring finger protein 12", "tax_id": 10090, "disease": "Tonne-Kalscheuer syndrome (Disease Ontology:DOID:0112042)", "pathway": " (mmu:19820); (R-MMU-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10431247;11882901;16204183;19945382;21183079;22596162;23904271;25428506;29742418;30084848;34428180;35857630;38113263", "class_list": "", "function": "An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42/REX1 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. E3 ubiquitin-protein ligase is required for proper regulation of neural cell differentiation from embryonic stem cells (PubMed:29742418)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CE02;Q91X19;Q9CYY2", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9WTV7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLJ1-1", "uniprot_id": [ { "id": "SELK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLJ1", "type": "external" } ], "mass": 10642.0, "length": 94, "protein_name": "Selenoprotein K", "gene_name": "Selenok", "organism": "Mouse", "refseq_name": "selenoprotein K", "refseq_ac": [ { "id": "NP_064363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064363", "type": "external" } ], "gene_names_uniprotkb": "Selenok; Selk", "gene_names_refseq": "1110001C03Rik; HSPC030; Hsp30; Selenok; Selk", "protein_names_uniprotkb": "Selenoprotein K; SelK", "protein_names_refseq": "heat shock protein, 30 kDa; selenoprotein K", "tax_id": 10090, "disease": "", "pathway": " (mmu:80795)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "20173027;21220695;21750661;21849499;22016385;23444136;25368151;25428506;30084848;34428180;35144051;37023217", "class_list": "", "function": "Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (PubMed:21220695). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (PubMed:23444136). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (By similarity). Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Sel K-deficient T cells exhibit decreased chemokine receptor-mediated calcium flux., [RefSeq, PubMed]; Selenoprotein K enhances STING oligomerization to facilitate antiviral response. Publication Status: Online-Only, [RefSeq, PubMed]; Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor 2,3,4 and 9-induced calpastatin in macrophages, [RefSeq, PubMed]; Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation., [RefSeq, PubMed]; The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Sep 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI00", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0010742 macrophage derived foam cell differentiation;GO:0051223 regulation of protein transport;GO:0006979 response to oxidative stress;GO:0030335 positive regulation of cell migration;GO:2000406 positive regulation of T cell migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42208-1", "uniprot_id": [ { "id": "SEPT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P42208", "type": "external" } ], "mass": 41526.0, "length": 361, "protein_name": "Septin-2", "gene_name": "Septin2", "organism": "Mouse", "refseq_name": "septin-2 isoform a", "refseq_ac": [ { "id": "NP_001153189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153189", "type": "external" } ], "gene_names_uniprotkb": "Septin2; Nedd5; Sept2", "gene_names_refseq": "Nedd-5; Nedd5; Sept2; Septin2; mKIAA0158", "protein_names_uniprotkb": "Septin-2; NEDD-5; Neural precursor cell expressed developmentally down-regulated protein 5", "protein_names_refseq": "neural precursor cell expressed, developmentally down-regulated gene 5; septin-2 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:18000); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "11739749;15592455;16452087;17242355;18630941;19131326;19144319;19805342;20558667;21183079;21750661;22179047;25428506;25588830;25605945;30084848;31219806;34428180;36721170;37453647;38357802;9203580", "class_list": "", "function": "Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements (By similarity). In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network. Publication Status: Online-Only, [RefSeq, PubMed]; S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRZ2;Q3U9Y5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0002036 regulation of L-glutamate import across plasma membrane;GO:0007283 spermatogenesis;GO:0031175 neuron projection development;GO:0007010 cytoskeleton organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P42208-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01405-1", "uniprot_id": [ { "id": "SC23A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01405", "type": "external" } ], "mass": 86162.0, "length": 765, "protein_name": "Protein transport protein Sec23A", "gene_name": "Sec23a", "organism": "Mouse", "refseq_name": "protein transport protein Sec23A", "refseq_ac": [ { "id": "NP_033173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033173", "type": "external" } ], "gene_names_uniprotkb": "Sec23a; Sec23r; Sec23", "gene_names_refseq": "Msec23; Sec23a; Sec23r", "protein_names_uniprotkb": "Protein transport protein Sec23A; SEC23-related protein A", "protein_names_refseq": "SEC23-related protein A; protein transport protein Sec23A", "tax_id": 10090, "disease": "craniolenticulosutural dysplasia (Disease Ontology:DOID:0070307); congenital dyserythropoietic anemia type II (Disease Ontology:DOID:0111401); Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (mmu:20334); (R-MMU-204005); (R-MMU-2132295); (R-MMU-5694530); (R-MMU-983170)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10400679;12193656;15466885;17428803;17452640;20485683;21750661;27354378;30084848;31599954;32848054;33300544;34421345;34428180;36064721;37453647;8417978", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZL4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0072659 protein localization to plasma membrane;GO:0090114 COPII-coated vesicle budding", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q01405-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q689Z5-1", "uniprot_id": [ { "id": "SBNO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q689Z5", "type": "external" } ], "mass": 153738.0, "length": 1390, "protein_name": "Protein strawberry notch homolog 1", "gene_name": "Sbno1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sbno1; Sno1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein strawberry notch homolog 1; mSno1", "protein_names_refseq": "", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;17045962;19224205;20173027;21183079;21606357;21750661;22517741;22645316;23443134;25428506;30059200;30084848;30779550;32782141;32848054;34428180;34678516;35822049;36852467;39343943;40021952;40885482", "class_list": "", "function": "Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQK3;Q8BVN5", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006954 inflammatory response;GO:0006355 regulation of DNA-templated transcription;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q689Z5-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNB8-1", "uniprot_id": [ { "id": "SBNO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNB8", "type": "external" } ], "mass": 149294.0, "length": 1349, "protein_name": "Protein strawberry notch homolog 2", "gene_name": "Sbno2", "organism": "Mouse", "refseq_name": "protein strawberry notch homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_906271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_906271", "type": "external" } ], "gene_names_uniprotkb": "Sbno2; Sno; Stno", "gene_names_refseq": "F730040C21; Sbno2; Sno; Stno", "protein_names_uniprotkb": "Protein strawberry notch homolog 2", "protein_names_refseq": "protein strawberry notch homolog 2 isoform 1; protein strawberry notch homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216161)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18025162;19224205;20173027;21750661;23980096;25605945;25903009;31219806;34428180;35624480;36210013", "class_list": "", "function": "Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions (PubMed:18025162, PubMed:23980096). Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast (PubMed:23980096). Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway (PubMed:23980096). May also be required in the regulation of osteoblast differentiation (PubMed:23980096). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade (By similarity)., [UniProtKB, UniProtKB, PubMed]; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade., [UniProtKB, UniProtKB, UniProtKB]; SBNO2 provides negative feedback to the transcriptional response to IL-6 Publication Status: Online-Only, [RefSeq, PubMed]; Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP., [RefSeq, PubMed]; The SBNO2 is component of the pathways that contribute to the downstream anti-inflammatory effects of IL-10. Erratum:[J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia [corrected to Panopoulos, Athanasia D]], [RefSeq, PubMed]; The findings of this study are consistent with SBNO2 functioning as an acute inflammatory response gene in astrocytes as well as other cells in the CNS., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE14;Q6P3A3;Q70X02", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0061430 bone trabecula morphogenesis;GO:0071348 cellular response to interleukin-11;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TNB8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8Y5-1", "uniprot_id": [ { "id": "SAMD7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8Y5", "type": "external" } ], "mass": 49259.0, "length": 445, "protein_name": "Sterile alpha motif domain-containing protein 7", "gene_name": "Samd7", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 7", "refseq_ac": [ { "id": "NP_083765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083765", "type": "external" } ], "gene_names_uniprotkb": "Samd7", "gene_names_refseq": "4930597A01Rik; Samd7", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 7; SAM domain-containing protein 7", "protein_names_refseq": "SAM domain-containing protein 7; sterile alpha motif domain-containing protein 7", "tax_id": 10090, "disease": "macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (mmu:75953)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23565263;28900001;33603070;38272031", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells (PubMed:28900001, PubMed:33603070). Via its association with the PRC1-like complex, promotes epigenetic repressive marks H3K27me3 and H2AK119ub marks in nonrod genes, silencing their transcription (PubMed:28900001). Represses Crx-controlled photoreceptor-specific gene expression (PubMed:23565263)., [UniProtKB, PubMed, PubMed, PubMed]; Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression., [RefSeq, PubMed]; The current study suggests that Samd7 is a cell type-specific PRC1 component epigenetically defining rod photoreceptor cell identity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8WHA0;G3UXH0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035102 PRC1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0046548 retinal rod cell development;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C8Y5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Z3-1", "uniprot_id": [ { "id": "S26A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Z3", "type": "external" } ], "mass": 71829.0, "length": 656, "protein_name": "Anion exchange transporter", "gene_name": "Slc26a7", "organism": "Mouse", "refseq_name": "anion exchange transporter", "refseq_ac": [ { "id": "NP_666059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666059", "type": "external" } ], "gene_names_uniprotkb": "Slc26a7", "gene_names_refseq": "Slc26a7", "protein_names_uniprotkb": "Anion exchange transporter; Solute carrier family 26 member 7", "protein_names_refseq": "anion exchange transporter; anion exchanger Slc26a7", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328)", "pathway": " (mmu:208890); (R-MMU-427601)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12736153;15591059;16263805;16524946;18209476;18663336;19723628;21750661;24810589;30333321;31599954;32726161;35788623", "class_list": "glycogene", "function": "Acts as an anion channel mediating the transport of chloride, bromide, iodide, nitrate, sulfate, gluconate, thiocyanate and bicarbonate ions (PubMed:15591059, PubMed:24810589, PubMed:30333321, PubMed:32726161, PubMed:35788623). Its permeability towards bicarbonate is weak and increases when pH is above 7 (PubMed:15591059). Mediates oxalate transport (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (PubMed:32726161). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:30333321, PubMed:35788623). Although it is an anion channel, according to PubMed:12736153 and PubMed:19723628 it has been shown to exhibit chloride-bicarbonate exchanger activity., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; CAII deficiency results in a significant decrease in the gene and protein expression of bicarbonate transport proteins from Slc26 gene family - Slc26a4 (pendrin) and Slc26a7., [RefSeq, PubMed]; Findings reveal that SLC26A7 functions as a unique Cl(-) channel that is regulated by intracellular H(+), [RefSeq, PubMed]; SLC26A7 constitutes the thiocyanate-selective anion conductance of the basolateral membrane of the retinal pigment epithelium., [RefSeq, PubMed]; SLC26A7 is a basolateral Cl(-)/HCO(3)(-) exchanger in gastric parietal cells and possibly plays a major role in gastric acid secretion, [RefSeq, PubMed]; Slc26a7 is expressed in the proximal tubule and thick ascending limb of the loop of Henle, and it may therefore contribute to anion transport in these nephron segments, [RefSeq, PubMed]; Study reports homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous congenital hypothyroidism and shows that goitrous hypothyroidism also occurs in Slc26a7-null mice. Publication Status: Online-Only, [RefSeq, PubMed]; Suggest that the increase in Slc26a7 expression caused by deletion of AE1 represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney., [RefSeq, PubMed]; The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJZ4;B1AWS0", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0005253 monoatomic anion channel activity;GO:0015106 bicarbonate transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0001696 gastric acid secretion;GO:0006821 chloride transport;GO:0015705 iodide transport;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R2Z3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1F9-1", "uniprot_id": [ { "id": "SAE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1F9", "type": "external" } ], "mass": 70569.0, "length": 638, "protein_name": "SUMO-activating enzyme subunit 2", "gene_name": "Uba2", "organism": "Mouse", "refseq_name": "SUMO-activating enzyme subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_057891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057891", "type": "external" } ], "gene_names_uniprotkb": "Uba2; Sae2; Uble1b", "gene_names_refseq": "Arx; Sae2; UBA1; Uba2; Ubl1a2; Uble1b", "protein_names_uniprotkb": "SUMO-activating enzyme subunit 2; 2.3.2.-; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2", "protein_names_refseq": "SUMO-activating enzyme subunit 2 isoform 1; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; Sumo-1 activating enzyme subunit 2; anthracycline-associated resistance ARX; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1 (sentrin) activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B", "tax_id": 10090, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (mmu:50995); (R-MMU-3065676); (R-MMU-3065678)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "11481243;16479539;20173027;21183079;21540332;21750661;22645316;22872234;23806337;24788674;25153642;28135057;28528544;30084848;31219806;31599954;33300544;34203471;34428180;36210013;39627609", "class_list": "", "function": "The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQN3;Q3U819;Q3U9J5;Q8BVX9", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0019948 SUMO activating enzyme activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016925 protein sumoylation;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9Z1F9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47867-1", "uniprot_id": [ { "id": "SCG3_MOUSE", "url": "https://www.uniprot.org/uniprot/P47867", "type": "external" } ], "mass": 53326.0, "length": 471, "protein_name": "Secretogranin-3", "gene_name": "Scg3", "organism": "Mouse", "refseq_name": "secretogranin-3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001158262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158262", "type": "external" } ], "gene_names_uniprotkb": "Scg3", "gene_names_refseq": "1B1075; Chgd; Scg3; SgIII", "protein_names_uniprotkb": "Secretogranin-3; Secretogranin III; SgIII", "protein_names_refseq": "secretogranin-3 isoform 2 precursor; secretogranin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20255); (R-MMU-114608); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12388744;16219686;17200173;18322192;21183079;21750661;28330905;30899004;34203471;34918375;35006382;35038348;7917832", "class_list": "", "function": "Comparative ligandomics implicates secretogranin III as a disease-restricted angiogenic factor in laser-induced choroidal neovascularization., [RefSeq, PubMed]; Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:16219686). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744). May also play a role in angiogenesis (PubMed:28330905). Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTT1;Q3UZT8;Q8R1D7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0033366 protein localization to secretory granule", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47867-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61620-1", "uniprot_id": [ { "id": "S61A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61620", "type": "external" } ], "mass": 52265.0, "length": 476, "protein_name": "Protein transport protein Sec61 subunit alpha isoform 1", "gene_name": "Sec61a1", "organism": "Mouse", "refseq_name": "protein transport protein Sec61 subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_058602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058602", "type": "external" } ], "gene_names_uniprotkb": "Sec61a1; Sec61a", "gene_names_refseq": "Sec61a1; Sec61a", "protein_names_uniprotkb": "Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1", "protein_names_refseq": "SEC61, alpha subunit; Sec61 alpha 1 subunit; protein transport protein Sec61 subunit alpha isoform 1; protein transport protein Sec61 subunit alpha; sec61 alpha-1; transport protein sec61 alpha subunit", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); autosomal dominant tubulointerstitial kidney disease 5 (Disease Ontology:DOID:0061120); common variable immunodeficiency (Disease Ontology:DOID:12177)", "pathway": " (mmu:53421)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "25428506;27392076;28679634;29795235;29915147;30084848;31219806;31877066;34428180;36210013;37453647", "class_list": "", "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (PubMed:27392076)., [UniProtKB, UniProtKB, PubMed]; Dynamics of triadin, a muscle-specific triad protein, within sarcoplasmic reticulum subdomains., [RefSeq, PubMed]; Nogo-C regulates cardiac fibrosis through interacting with Sec61alpha to mediate the Ca(2+) leakage from endoplasmic reticulum. Publication Status: Online-Only, [RefSeq, PubMed]; Sec61 blockade induces proteostatic stress in the cytosol and the endoplasmic reticulum., [RefSeq, PubMed]; The direct contribution of Sec61 to antigen cross-presentation, endosome-to-cytosol export, and endoplasmic reticulum-to-cytosol export., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P38378;P57726;Q3TXA5", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0022857 transmembrane transporter activity;GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030670 phagocytic vesicle membrane;GO:0005784 Sec61 translocon complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P61620-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDA1-1", "uniprot_id": [ { "id": "SAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDA1", "type": "external" } ], "mass": 127608.0, "length": 1132, "protein_name": "Phosphatidylinositide 4-phosphatase SAC2", "gene_name": "Inpp5f", "organism": "Mouse", "refseq_name": "phosphatidylinositide 4-phosphatase SAC2 isoform 2", "refseq_ac": [ { "id": "NP_001333446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333446", "type": "external" } ], "gene_names_uniprotkb": "Inpp5f; Kiaa0966; Sac2", "gene_names_refseq": "5830435P03Rik; Inpp5f; SAC2; cI-27; hSAC2; mKIAA0966", "protein_names_uniprotkb": "Phosphatidylinositide 4-phosphatase SAC2; 3.1.3.-; Inositol polyphosphate 5-phosphatase F; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2; hSAC2", "protein_names_refseq": "phosphatidylinositide 4-phosphatase SAC2 isoform 2; phosphatidylinositide 4-phosphatase SAC2; phosphatidylinositide phosphatase SAC2; sac domain-containing inositol phosphatase 2; sac domain-containing phosphoinositide 4-phosphatase 2; sac domain-containing phosphoinositide 5-phosphatase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:101490); (R-MMU-1660516)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15964807;17242355;17322895;19875726;21183079;21750661;25869668;25869669;26203138;26908121;31219806;31533953;32424101;34428180;34996491", "class_list": "", "function": "A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island., [RefSeq, PubMed]; Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1., [RefSeq, PubMed]; Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Publication Status: Online-Only, [RefSeq, PubMed]; INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PtdIns(4)P). May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns, for a sequential dephosphorylation of (PtdIns(4,5)P2) at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (By similarity). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (PubMed:19875726). May play a role as negative regulator of axon regeneration after central nervous system injuries (PubMed:26203138). May be involved in insulin granule docking at the plasma membrane of pancreatic cells, an essential step for insulin secretion (PubMed:31533953)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This study reveals Inpp5f (Sac2) as a novel suppressor of CNS axon repair after spinal cord injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCS0;Q6NX83;Q6ZQ16;Q8C8G7;Q8CBW2", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity;GO:0042803 protein homodimerization activity;GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity;GO:0052833 inositol monophosphate 4-phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005905 clathrin-coated pit;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0031161 phosphatidylinositol catabolic process;GO:0008344 adult locomotory behavior;GO:2000145 regulation of cell motility;GO:0001921 positive regulation of receptor recycling", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CDA1-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CTN5-1", "uniprot_id": [ { "id": "S6OS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CTN5", "type": "external" } ], "mass": 66867.0, "length": 574, "protein_name": "Protein SIX6OS1", "gene_name": "4930447C04Rik; Six6os1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "4930447C04Rik; Six6os1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein SIX6OS1; Six6 opposite strand transcript 1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary ovarian insufficiency 18 (Disease Ontology:DOID:0112269); spermatogenic failure 52 (Disease Ontology:DOID:0112270)", "pathway": " (mmu:75801)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15703187;21183079;21750661;27796301;30272023;30746471;31437213;33508233", "class_list": "", "function": "Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination (PubMed:27796301, PubMed:33508233). Required for the appropriate processing of intermediate recombination nodules before crossover formation (PubMed:27796301)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5F5;Q9D5Y9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0005694 chromosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis;GO:0010705 meiotic DNA double-strand break processing involved in reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CTN5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY16-1", "uniprot_id": [ { "id": "RT28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY16", "type": "external" } ], "mass": 20520.0, "length": 186, "protein_name": "Small ribosomal subunit protein bS1m", "gene_name": "Mrps28", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein bS1m", "refseq_ac": [ { "id": "NP_079710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079710", "type": "external" } ], "gene_names_uniprotkb": "Mrps28", "gene_names_refseq": "1500012D08Rik; Mrps28", "protein_names_uniprotkb": "Small ribosomal subunit protein bS1m; 28S ribosomal protein S28, mitochondrial; MRP-S28; S28mt", "protein_names_refseq": "28S ribosomal protein S28, mitochondrial; MRP-S28; S28mt; small ribosomal subunit protein bS1m", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 47 (Disease Ontology:DOID:0112114)", "pathway": " (mmu:66230); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17242355;21183079;34428180;36288343", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2K6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CY16-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RQE8-1", "uniprot_id": [ { "id": "RHG42_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RQE8", "type": "external" } ], "mass": 94636.0, "length": 841, "protein_name": "Rho GTPase-activating protein 42", "gene_name": "Arhgap42", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 42 isoform 3", "refseq_ac": [ { "id": "NP_082099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082099", "type": "external" } ], "gene_names_uniprotkb": "Arhgap42; Graf3", "gene_names_refseq": "9030420J04Rik; Arhgap42", "protein_names_uniprotkb": "Rho GTPase-activating protein 42; Rho-type GTPase-activating protein 42", "protein_names_refseq": "VRho GTPase activating protein 42; rho GTPase-activating protein 42 isoform 3", "tax_id": 10090, "disease": "Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311)", "pathway": " (mmu:71544); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;24335996;28112683;28584191;31219806;32331391;34428180;40021952", "class_list": "", "function": "Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding, [RefSeq, PubMed]; GRAF3 is expressed in a smooth muscle-restricted fashion., [RefSeq, PubMed]; May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle., [UniProtKB, PubMed]; Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of ARHGAP42 Tyr-376 is revealed as a novel regulatory event by which Src can affect actin dynamics through RhoA inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0003085 negative regulation of systemic arterial blood pressure;GO:0090630 activation of GTPase activity;GO:0035024 negative regulation of Rho protein signal transduction;GO:1904694 negative regulation of vascular associated smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "B2RQE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUG2-1", "uniprot_id": [ { "id": "POLK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUG2", "type": "external" } ], "mass": 96003.0, "length": 852, "protein_name": "DNA polymerase kappa", "gene_name": "Polk", "organism": "Mouse", "refseq_name": "DNA polymerase kappa isoform a", "refseq_ac": [ { "id": "NP_036178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036178", "type": "external" } ], "gene_names_uniprotkb": "Polk; Dinb1", "gene_names_refseq": "DINP; Dinb1; Polk", "protein_names_uniprotkb": "DNA polymerase kappa; 2.7.7.7; DINB protein; DINP", "protein_names_refseq": "DINB protein; DNA damage-inducible protein b; DNA polymerase kappa isoform a; DNA-directed DNA polymerase kappa; DinB homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27015); (R-MMU-5655862); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "10518552;10620008;12432099;14657033;15661663;21750661;22859295;26634445;29076178;30620413;31219806;34428180", "class_list": "", "function": "DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099). Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The extreme N-terminal part of Polkappa is required for the processivity and fidelity of Polkappa during translesion synthesis of 10S(+)-trans-anti-benzo[a]pyrene diol epoxide-N(2)-deoxyguanine adducts lesions., [RefSeq, PubMed]; The multiple mouse/human (PolK/POLK) transcripts may encode multiple Polkappa isoforms in testis, [RefSeq, PubMed]; The results indicate that Polkappa does not suppress benzo[a]pyrene -induced mutagenesis and carcinogenesis in the colon, but counteracts inflammation-induced mutagenesis in multiple organs., [RefSeq, PubMed]; The results suggest that Polk has a limited ability to suppress BP-induced genotoxicity in the colon and bone marrow and also that the roles of specialized DNA polymerases in mutagenesis and carcinogenesis should be examined not only by in vitro assays but also by in vivo mouse studies. We also report the spontaneous mutagenesis in inactivated Polk KI mice at young and old ages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPY7", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0090734 site of DNA damage", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QUG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZK0-1", "uniprot_id": [ { "id": "PREX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZK0", "type": "external" } ], "mass": 184935.0, "length": 1650, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "gene_name": "Prex1", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "refseq_ac": [ { "id": "NP_808450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808450", "type": "external" } ], "gene_names_uniprotkb": "Prex1; Kiaa1415", "gene_names_refseq": "G630042G04; P-REX1; Prex1; Setd6", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; P-Rex1; PtdIns(3,4,5)-dependent Rac exchanger 1", "protein_names_refseq": "SET domain containing 6; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; ptdIns(3,4,5)-dependent Rac exchanger 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:277360); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423)", "pathway_count": 13, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16243035;16243036;21183079;21750661;25533347;25605945;33097662;34428180;36210013;36892683;40885482", "class_list": "", "function": "Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils., [RefSeq, PubMed]; P-Rex1 is an important regulator of neutrophil function by mediating a subset of Rac-dependent neutrophil responses., [RefSeq, PubMed]; Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis., [RefSeq, PubMed]; PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A5U1;Q6PFD4;Q8BN08", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043198 dendritic shaft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q69ZK0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJS4-1", "uniprot_id": [ { "id": "SUN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJS4", "type": "external" } ], "mass": 81605.0, "length": 731, "protein_name": "SUN domain-containing protein 2", "gene_name": "Sun2", "organism": "Mouse", "refseq_name": "SUN domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001192274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192274", "type": "external" } ], "gene_names_uniprotkb": "Sun2; Unc84b", "gene_names_refseq": "B230369L08Rik; C030011B15; Sun2; Unc84b", "protein_names_uniprotkb": "SUN domain-containing protein 2; Protein unc-84 homolog B; Sad1/unc-84 protein-like 2", "protein_names_refseq": "SUN domain-containing protein 2 isoform 1; SUN domain-containing protein 2; protein unc-84 homolog B; sad1/unc-84 protein-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223697)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;12393179;16380439;17132086;17242355;17452644;19509342;19656770;19843581;19874786;19933576;20724637;21177258;21183079;21750661;22349700;23071752;24586178;26495903;26688217;29878215;30899004;31219806;34428180;34887587;36210013;36852467;37188462;38177122;39627609;40021952;40885482;40997131", "class_list": "", "function": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Publication Status: Online-Only, [RefSeq, PubMed]; SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome, [RefSeq, PubMed]; Sun2 is part of a membrane-spanning fibrillar complex that interconnects attached telomeres with cytoplasmic structures, [RefSeq, PubMed]; These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBU0;Q3U160;Q6B4H2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity;GO:0005521 lamin binding;GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0010008 endosome membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0031022 nuclear migration along microfilament;GO:0090292 nuclear matrix anchoring at nuclear membrane;GO:0030335 positive regulation of cell migration;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q8BJS4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ALS5-1", "uniprot_id": [ { "id": "RPGP1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ALS5", "type": "external" } ], "mass": 73433.0, "length": 663, "protein_name": "Rap1 GTPase-activating protein 1", "gene_name": "Rap1gap", "organism": "Mouse", "refseq_name": "rap1 GTPase-activating protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624", "type": "external" } ], "gene_names_uniprotkb": "Rap1gap; Kiaa0474; Rap1ga1", "gene_names_refseq": "1300019I11Rik; 2310004O14Rik; ARPP-90; Gap; Rap1GAP1; Rap1ga1; Rap1gap", "protein_names_uniprotkb": "Rap1 GTPase-activating protein 1; ARPP-90; Rap1GAP1; Rap1GAP", "protein_names_refseq": "rap1 GTPase-activating protein 1 isoform 1; rap1 GTPase-activating protein 1", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); bipolar disorder (Disease Ontology:DOID:3312); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:110351); (R-MMU-392517); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12082090;12172908;12873387;14643017;19218462;21183079;21750661;22645316;33300544;40885482", "class_list": "", "function": "ERK activation by cAMP does not require RAP1, [RefSeq, PubMed]; Evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells., [RefSeq, PubMed]; Expression studies show that mr-gef is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ)., [RefSeq, PubMed]; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB]; Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PZZ8;Q6A063;Q80VZ8;Q8K2L6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:1903697 negative regulation of microvillus assembly;GO:0043547 positive regulation of GTPase activity;GO:0045665 negative regulation of neuron differentiation;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A2ALS5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WM1-1", "uniprot_id": [ { "id": "STRBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WM1", "type": "external" } ], "mass": 73705.0, "length": 672, "protein_name": "Spermatid perinuclear RNA-binding protein", "gene_name": "Strbp", "organism": "Mouse", "refseq_name": "spermatid perinuclear RNA-binding protein isoform a", "refseq_ac": [ { "id": "NP_033287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033287", "type": "external" } ], "gene_names_uniprotkb": "Strbp; Spnr", "gene_names_refseq": "6430510M02Rik; C230082I21Rik; Spnr; Strbp", "protein_names_uniprotkb": "Spermatid perinuclear RNA-binding protein", "protein_names_refseq": "spermatid perinuclear RNA-binding protein isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:20744)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11336498;16033648;21750661;24129315;30084848;31219806;34428180;7744952;9674995", "class_list": "", "function": "Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Also binds to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62262", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008017 microtubule binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015630 microtubule cytoskeleton;GO:0002177 manchette", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0007286 spermatid development;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91WM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6B2-1", "uniprot_id": [ { "id": "RTKN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6B2", "type": "external" } ], "mass": 63013.0, "length": 564, "protein_name": "Rhotekin", "gene_name": "Rtkn", "organism": "Mouse", "refseq_name": "rhotekin isoform a", "refseq_ac": [ { "id": "NP_001129699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129699", "type": "external" } ], "gene_names_uniprotkb": "Rtkn", "gene_names_refseq": "Rtkn", "protein_names_uniprotkb": "Rhotekin", "protein_names_refseq": "rhotekin isoform a", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20166); (R-MMU-5666185); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "21750661;22503686;24129315;25428506;31219806;8662891", "class_list": "", "function": "Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity)., [UniProtKB]; These findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QM24;Q61192;Q8VIG7", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0005095 GTPase inhibitor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005826 actomyosin contractile ring", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0007266 Rho protein signal transduction;GO:0042981 regulation of apoptotic process;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C6B2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4D7-1", "uniprot_id": [ { "id": "PLCZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4D7", "type": "external" } ], "mass": 74614.0, "length": 647, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "gene_name": "Plcz1", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "refseq_ac": [ { "id": "NP_473407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473407", "type": "external" } ], "gene_names_uniprotkb": "Plcz1", "gene_names_refseq": "1700041H07Rik; PLCzeta; Plcz1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; 3.1.4.11; PLC-zeta-1; Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; PLC-zeta-1; phosphoinositide phospholipase C-zeta-1; phospholipase C zeta", "tax_id": 10090, "disease": "spermatogenic failure 17 (Disease Ontology:DOID:0070174)", "pathway": " (mmu:114875); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12117804;14701816;15159452;15385165;15790568;15809052;16000311;16854985;17933795;18028898;18322275;21750661;33208563;35547809;36613757", "class_list": "", "function": "Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains., [RefSeq, PubMed]; Cell cycle-dependent Ca2+ oscillations are regulated by nuclear targeting of PlCzeta., [RefSeq, PubMed]; Plcz1 Deficiency Decreased Fertility in Male Mice Which Is Associated with Sperm Quality Decline and Abnormal Cytoskeleton in Epididymis. Publication Status: Online-Only, [RefSeq, PubMed]; Purified PLCzeta protein induces Ca(2+) oscillations, indicating that PLCzeta is a proper candidate of the mammalian egg-activating sperm factor, [RefSeq, PubMed]; Results are consistent with sperm phospholipse C zeta as the molecular trigger for development of a fertilised egg into an embryo, [RefSeq, PubMed]; Results suggest a mechanism by which phospholipase C zeta originates from an oocyte-penetrating assembly--the sperm perinuclear matrix--to induce mammalian oocyte activation at fertilization., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KPE5", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0035556 intracellular signal transduction;GO:0006816 calcium ion transport;GO:0016042 lipid catabolic process;GO:0007343 egg activation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K4D7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJM3-1", "uniprot_id": [ { "id": "R3HCL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJM3", "type": "external" } ], "mass": 84481.0, "length": 775, "protein_name": "Coiled-coil domain-containing protein R3HCC1L", "gene_name": "R3hcc1l", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein R3HCC1L", "refseq_ac": [ { "id": "NP_803415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803415", "type": "external" } ], "gene_names_uniprotkb": "R3hcc1l; D19Ertd386e; Gidrp88", "gene_names_refseq": "1700036B12Rik; C10orf28; D19Ertd386e; GIDRP86; Gidrp88; R3hcc1l", "protein_names_uniprotkb": "Coiled-coil domain-containing protein R3HCC1L; Growth inhibition and differentiation-related protein 88 homolog; R3H and coiled-coil domain-containing protein 1-like", "protein_names_refseq": "coiled-coil domain-containing protein R3HCC1L; growth inhibition and differentiation related protein 86; growth inhibition and differentiation-related protein 88 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:52013)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGJ8;Q5U5U8", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BJM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP71-1", "uniprot_id": [ { "id": "RFOX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP71", "type": "external" } ], "mass": 47330.0, "length": 449, "protein_name": "RNA binding protein fox-1 homolog 2", "gene_name": "Rbfox2", "organism": "Mouse", "refseq_name": "RNA binding protein fox-1 homolog 2 isoform 3", "refseq_ac": [ { "id": "NP_001104297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104297", "type": "external" } ], "gene_names_uniprotkb": "Rbfox2; Fox2; Fxh; Hrnbp2; Rbm9", "gene_names_refseq": "Fbm2; Fxh; Hrnbp2; Rbfox2; Rbm9", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 2; Fox-1 homolog B; Fox-1 homolog Fxh; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9", "protein_names_refseq": "Fyn-binding molecule 2; RNA binding protein fox-1 homolog 2 isoform 3; RNA-binding motif protein 9; fox-1 homolog B; fox-1 homolog Fxh; hexaribonucleotide-binding protein 2", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); congenital heart disease (Disease Ontology:DOID:1682); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:93686)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11401487;15824060;16260614;16449636;16537540;17101796;17715393;21750661;24129315;32848054;34428180;36536133;36674797;38007492;40997131", "class_list": "", "function": "Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice., [RefSeq, PubMed]; Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; RNA-binding protein that regulates alternative splicing events., [UniProtKB, UniProtKB]; Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0R5Z7;Q0R5Z8;Q0VH84;Q537D4;Q537D5;Q8BRG0;Q8R2T5;Q8VI62;Q923W8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003714 transcription corepressor activity;GO:0003727 single-stranded RNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:1902631 negative regulation of membrane hyperpolarization;GO:1990859 cellular response to endothelin;GO:0010724 regulation of definitive erythrocyte differentiation;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BP71-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ43-1", "uniprot_id": [ { "id": "RFOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ43", "type": "external" } ], "mass": 42678.0, "length": 396, "protein_name": "RNA binding protein fox-1 homolog 1", "gene_name": "Rbfox1", "organism": "Mouse", "refseq_name": "RNA binding protein fox-1 homolog 1 isoform gamma", "refseq_ac": [ { "id": "NP_067452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067452", "type": "external" } ], "gene_names_uniprotkb": "Rbfox1; A2bp1; A2bp; Fox1; MNCb-3035", "gene_names_refseq": "A2bp1; A2bp; Hrnbp1; Rbfox1; fox-1", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 1; Ataxin-2-binding protein 1; Fox-1 homolog A", "protein_names_refseq": "RNA binding protein fox-1 homolog 1 isoform gamma; RNA binding protein fox-1 homolog 1; ataxin 2 binding protein 1; fox-1 homolog A; hexaribonucleotide binding protein 1", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:268859)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10814712;12574126;15824060;16260614;17101796;21750661;24129315;25428506;32848054;36359797", "class_list": "", "function": "RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; RNA-binding protein that regulates alternative splicing events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYA8;Q537C9;Q537D0;Q537D1;Q537D2;Q6PD12;Q8R4Z7;Q9JJB5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0050885 neuromuscular process controlling balance;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JJ43-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX57-1", "uniprot_id": [ { "id": "PXK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX57", "type": "external" } ], "mass": 65231.0, "length": 582, "protein_name": "PX domain-containing protein kinase-like protein", "gene_name": "Pxk", "organism": "Mouse", "refseq_name": "PX domain-containing protein kinase-like protein long isoform", "refseq_ac": [ { "id": "NP_663433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663433", "type": "external" } ], "gene_names_uniprotkb": "Pxk", "gene_names_refseq": "C230080L11Rik; D14Ertd813e; Monaka; Pxk; Slob", "protein_names_uniprotkb": "PX domain-containing protein kinase-like protein; MONaKA; Modulator of Na,K-ATPase", "protein_names_refseq": "PX domain-containing protein kinase-like protein long isoform; PX domain-containing protein kinase-like protein; modulator of Na,K-ATPase", "tax_id": 10090, "disease": "polycythemia due to hypoxia (Disease Ontology:DOID:2835)", "pathway": " (mmu:218699)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16135750;21750661;25428506;28528544;30084848;31219806;34203471;34428180", "class_list": "", "function": "Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD60;Q3TEL7;Q3TZZ1;Q3U197;Q3U773;Q3UCS5;Q4FBH7;Q91WB6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006954 inflammatory response;GO:0050804 modulation of chemical synaptic transmission;GO:0032780 negative regulation of ATP-dependent activity;GO:0043271 negative regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BX57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09242-1", "uniprot_id": [ { "id": "PPBT_MOUSE", "url": "https://www.uniprot.org/uniprot/P09242", "type": "external" } ], "mass": 57514.0, "length": 524, "protein_name": "Alkaline phosphatase, tissue-nonspecific isozyme", "gene_name": "Alpl", "organism": "Mouse", "refseq_name": "alkaline phosphatase, tissue-nonspecific isozyme preproprotein", "refseq_ac": [ { "id": "NP_001274101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274101", "type": "external" } ], "gene_names_uniprotkb": "Alpl; Akp-2; Akp2", "gene_names_refseq": "ALP; APTNAP; Akp-2; Akp2; Alpl; TNAP; TNSALP", "protein_names_uniprotkb": "Alkaline phosphatase, tissue-nonspecific isozyme; 3.1.3.1; 3.9.1.1; AP-TNAP; Alkaline phosphatase 2; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; TNAP; TNSALP", "protein_names_refseq": "alkaline phosphatase 2, liver; alkaline phosphatase, tissue-nonspecific isozyme preproprotein; alkaline phosphatase, tissue-nonspecific isozyme; phosphoamidase; phosphocreatine phosphatase", "tax_id": 10090, "disease": "adult hypophosphatasia (Disease Ontology:DOID:0110913); infantile hypophosphatasia (Disease Ontology:DOID:0110914); childhood hypophosphatasia (Disease Ontology:DOID:0110915); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypophosphatasia (Disease Ontology:DOID:14213); arteriosclerosis (Disease Ontology:DOID:2349); uremia (Disease Ontology:DOID:4676); in situ carcinoma (Disease Ontology:DOID:8719); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:11647); (R-MMU-163125)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10620060;11004006;11028439;11169525;12082181;14982838;17539739;19349973;19874193;20684022;21183079;21191615;2165496;21750661;23427088;23825434;23942722;24028588;26457330;28935714;29148101;29174347;30899004;32028019;32035618;33300544;33981039;34428180;3478679;7550313;7789278;9056646", "class_list": "", "function": "Alkaline phosphatase 2(Hpp/Hpp) mice develop late-onset skeletal disease, notably defective endochondral ossification and bone mineralization that leads to arthropathies of knees and shoulders, [RefSeq, PubMed]; Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:10620060, PubMed:11028439, PubMed:14982838, PubMed:23942722, PubMed:33981039). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:19874193, PubMed:23942722, PubMed:33981039). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:10620060, PubMed:11004006, PubMed:11028439, PubMed:12082181, PubMed:14982838, PubMed:32035618, PubMed:9056646). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (PubMed:20684022, PubMed:26457330). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (PubMed:23427088). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:7550313). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (PubMed:19874193, PubMed:23825434, PubMed:23942722, PubMed:32028019). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (By similarity). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (PubMed:33981039). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (PubMed:33981039)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data show that alkaline phosphatase (AP) activity in brain vessels and parenchyma in which AP exhibits specific patterns is attributable to TNAP., [RefSeq, PubMed]; This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]; Tissue-nonspecific alkaline phosphatase is the enzyme that hydrolyzes both ATP and inorganic pyrophosate in matrix vesicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 19, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1B0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.4.17.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.12", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.1.3.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.75", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0033883 pyridoxal phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0004035 alkaline phosphatase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005615 extracellular space;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:1904383 response to sodium phosphate;GO:0032496 response to lipopolysaccharide;GO:0051384 response to glucocorticoid;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "P09242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z89-1", "uniprot_id": [ { "id": "RADIL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z89", "type": "external" } ], "mass": 120355.0, "length": 1099, "protein_name": "Ras-associating and dilute domain-containing protein", "gene_name": "Radil", "organism": "Mouse", "refseq_name": "ras-associating and dilute domain-containing protein isoform 3", "refseq_ac": [ { "id": "NP_001297681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297681", "type": "external" } ], "gene_names_uniprotkb": "Radil; Kiaa1849", "gene_names_refseq": "D930005D10Rik; Radil", "protein_names_uniprotkb": "Ras-associating and dilute domain-containing protein", "protein_names_refseq": "ras-associating and dilute domain-containing protein isoform 3; ras-associating and dilute domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:231858)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17704304;21183079;21750661", "class_list": "", "function": "Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNL0;Q8C549;Q8C6X2;Q8CAL1", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding", "go_cellular_component": "GO:0005874 microtubule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0001755 neural crest cell migration;GO:0034446 substrate adhesion-dependent cell spreading;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q69Z89-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32883-1", "uniprot_id": [ { "id": "RASK_MOUSE", "url": "https://www.uniprot.org/uniprot/P32883", "type": "external" } ], "mass": 21656.0, "length": 189, "protein_name": "GTPase KRas", "gene_name": "Kras", "organism": "Mouse", "refseq_name": "GTPase KRas isoform 1", "refseq_ac": [ { "id": "NP_067259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067259", "type": "external" } ], "gene_names_uniprotkb": "Kras; Kras2", "gene_names_refseq": "K-Ras 2; K-Ras; K-ras; Ki-ras; Kras-2; Kras2; Kras; c-K-ras; c-Ki-ras; p21B; ras", "protein_names_uniprotkb": "GTPase KRas; 3.6.5.2; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras", "protein_names_refseq": "GTPase KRas isoform 1; GTPase KRas; Kirsten rat sarcoma oncogene 2, expressed; p21 protein; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); hepatocellular adenoma (Disease Ontology:DOID:0050868); cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); Noonan syndrome 3 (Disease Ontology:DOID:0060581); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); endometrial hyperplasia (Disease Ontology:DOID:0080365); RASopathy (Disease Ontology:DOID:0080690); autoimmune lymphoproliferative syndrome type 4 (Disease Ontology:DOID:0110117); cardiofaciocutaneous syndrome 2 (Disease Ontology:DOID:0111461); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); oculoectodermal syndrome (Disease Ontology:DOID:0111705); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); kidney cancer (Disease Ontology:DOID:263); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometriosis (Disease Ontology:DOID:289); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); anaplastic astrocytoma (Disease Ontology:DOID:3078); Noonan syndrome (Disease Ontology:DOID:3490); Lynch syndrome (Disease Ontology:DOID:3883); lung adenocarcinoma (Disease Ontology:DOID:3910); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatic carcinoma (Disease Ontology:DOID:4905); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); Klatskin's tumor (Disease Ontology:DOID:4927); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); stomach carcinoma (Disease Ontology:DOID:5517); fibrillary astrocytoma (Disease Ontology:DOID:6726); hepatocellular carcinoma (Disease Ontology:DOID:684); pancreatic mucinous cystadenoma (Disease Ontology:DOID:7235); muscular atrophy (Disease Ontology:DOID:767); myeloid sarcoma (Disease Ontology:DOID:8683); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:16653); (R-MMU-1169092); (R-MMU-1250347); (R-MMU-1433557); (R-MMU-171007); (R-MMU-179812); (R-MMU-180336); (R-MMU-186763); (R-MMU-1963640); (R-MMU-210993); (R-MMU-2179392); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-375165); (R-MMU-4086398); (R-MMU-5218921); (R-MMU-5621575); (R-MMU-5654688); (R-MMU-5654693); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5658442); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-5674135); (R-MMU-5675221); (R-MMU-8849471); (R-MMU-8851805); (R-MMU-9607240); (R-MMU-9634635); (R-MMU-9648002); (R-MMU-9674555)", "pathway_count": 36, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1352876;21750661;25077772;29137294;33300544;34428180;4006913;6474169;6546797", "class_list": "", "function": "Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:1352876, PubMed:6474169). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 54, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P04200;P08643", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning;GO:0010628 positive regulation of gene expression;GO:0035900 response to isolation stress", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32883-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5F9-1", "uniprot_id": [ { "id": "SETD2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5F9", "type": "external" } ], "mass": 285663.0, "length": 2537, "protein_name": "Histone-lysine N-methyltransferase SETD2", "gene_name": "Setd2", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SETD2", "refseq_ac": [ { "id": "NP_001074809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074809", "type": "external" } ], "gene_names_uniprotkb": "Setd2; Kiaa1732; Kmt3a", "gene_names_refseq": "4921524K10Rik; KMT3A; Setd2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD2; 2.1.1.-; 2.1.1.359; Lysine N-methyltransferase 3A; Protein-lysine N-methyltransferase SETD2; SET domain-containing protein 2", "protein_names_refseq": "SET domain-containing protein 2; histone-lysine N-methyltransferase SETD2; lysine N-methyltransferase 3A; protein-lysine N-methyltransferase SETD2", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); autosomal dominant intellectual developmental disorder 70 (Disease Ontology:DOID:0061043); stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); malignant mesothelioma (Disease Ontology:DOID:1790); liver cancer (Disease Ontology:DOID:3571); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); malignant pleural mesothelioma (Disease Ontology:DOID:7474); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:235626); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "18157086;19144319;20133625;21183079;21750661;21952136;25242323;25428506;25605945;27518565;34428180;34678516;38537781;39115793;39366177;39390582;40997131", "class_list": "", "function": "Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation., [RefSeq, PubMed]; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:18157086, PubMed:20133625). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (By similarity). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (PubMed:18157086, PubMed:20133625). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (By similarity). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (By similarity). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (By similarity). Acts as a tumor suppressor (By similarity). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (By similarity). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (By similarity). Required during angiogenesis (PubMed:20133625). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (PubMed:25242323). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; SET domain containing 2 promotes megakaryocyte polyploidization and platelet generation through methylation of alpha-tubulin., [RefSeq, PubMed]; SETD2 regulates SLC family transporter-mediated sodium and glucose reabsorptions in renal tubule., [RefSeq, PubMed]; Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZC0;Q6PCY9;Q8K0F3", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043014 alpha-tubulin binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140955 histone H3K36 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0034728 nucleosome organization;GO:0048332 mesoderm morphogenesis;GO:1902850 microtubule cytoskeleton organization involved in mitosis;GO:1905634 regulation of protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9Q5F9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRD0-1", "uniprot_id": [ { "id": "OCAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRD0", "type": "external" } ], "mass": 27610.0, "length": 247, "protein_name": "OCIA domain-containing protein 1", "gene_name": "Ociad1", "organism": "Mouse", "refseq_name": "OCIA domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001153359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153359", "type": "external" } ], "gene_names_uniprotkb": "Ociad1; Asrij", "gene_names_refseq": "6030432N09Rik; Asrij; B230209J16Rik; Emi2; Imi2; OCIA; Ociad1; TPA018", "protein_names_uniprotkb": "OCIA domain-containing protein 1", "protein_names_refseq": "OCIA domain-containing protein 1 isoform 2; OCIA domain-containing protein 1; expressed during mesenchymal induction 2; induced during mesenchymal induction 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68095)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12889067;17242355;21183079;21750661;22645316;23972987;25153642;25428506;25605945;26495903;28135057;31931285;34428180;36288343;37453647", "class_list": "", "function": "Asrij is expressed predominantly in mouse embryonic blood vessels; a splice variant is expressed in the brain, and can serve as an early stem cell marker., [RefSeq, PubMed]; Asrij regulates mouse embryonic stem cell pluripotency via JAK/STAT signaling., [RefSeq, PubMed]; Maintains stem cell potency (PubMed:23972987). Increases STAT3 phosphorylation and controls ERK phosphorylation (PubMed:23972987). May act as a scaffold, increasing STAT3 recruitment onto endosomes (PubMed:23972987)., [UniProtKB, PubMed]; OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEC2;Q3TJS3;Q7TNB3;Q922M2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:2000736 regulation of stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CRD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88907-1", "uniprot_id": [ { "id": "PIAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88907", "type": "external" } ], "mass": 71618.0, "length": 651, "protein_name": "E3 SUMO-protein ligase PIAS1", "gene_name": "Pias1", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase PIAS1", "refseq_ac": [ { "id": "NP_062637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062637", "type": "external" } ], "gene_names_uniprotkb": "Pias1; Ddxbp1", "gene_names_refseq": "2900068C24Rik; Ddxbp1; GBP; Pias1", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS1; 2.3.2.27; DEAD/H box-binding protein 1; Protein inhibitor of activated STAT protein 1; RING-type E3 ubiquitin transferase PIAS1", "protein_names_refseq": "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; RING-type E3 ubiquitin transferase PIAS1; protein inhibitor of activated STAT protein 1", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (mmu:56469); (R-MMU-3108214); (R-MMU-3232118); (R-MMU-3232142); (R-MMU-3899300); (R-MMU-4090294); (R-MMU-4551638); (R-MMU-5696395); (R-MMU-877312)", "pathway_count": 9, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10854042;11117529;11788578;11877418;12077349;12855578;16600910;17187077;17242355;17938210;21183079;21750661;22406621;24061474;25428506;30084848;31219806;34187905;34428180;35377920;38102979;40997131;9724754", "class_list": "", "function": "Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:24061474). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2, PML and ZNF76 (PubMed:24061474). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (By similarity). In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (By similarity). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (By similarity). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (PubMed:22406621). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (PubMed:22406621). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (PubMed:16600910). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (PubMed:16600910). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (PubMed:16600910)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence. Publication Status: Online-Only, [RefSeq, PubMed]; Protein inhibitor of activated Stat1 (PIAS1) interacts with the tetramerization and C-terminal regulatory domains of p53 in yeast two-hybrid analyses, [RefSeq, PubMed]; Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators., [RefSeq, PubMed]; SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-kappaB and Notch signaling. Publication Status: Online-Only, [RefSeq, PubMed]; SUMOylation and coupling of eNOS mediated by PIAS1 contribute to maintenance of vascular homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6H5", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0016607 nuclear speck", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O88907-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV89-1", "uniprot_id": [ { "id": "STXB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV89", "type": "external" } ], "mass": 61689.0, "length": 557, "protein_name": "Syntaxin-binding protein 4", "gene_name": "Stxbp4", "organism": "Mouse", "refseq_name": "syntaxin-binding protein 4", "refseq_ac": [ { "id": "NP_035635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035635", "type": "external" } ], "gene_names_uniprotkb": "Stxbp4", "gene_names_refseq": "6030470M02Rik; Stxbp4; Synip", "protein_names_uniprotkb": "Syntaxin-binding protein 4; STX4-interacting protein; Synip; Syntaxin 4-interacting protein", "protein_names_refseq": "STX4-interacting protein; syntaxin 4-interacting protein; syntaxin-binding protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:20913)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10394363;12855681;15753124;21183079;21750661;29767852;34203471", "class_list": "", "function": "Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose., [UniProtKB, PubMed, PubMed]; Syntaxin-4 directly binds to E-cadherin and activates part of Smad signals, leading to the disruption of epithelial intercellular adhesion and an augmented expression of fibroblast markers. These findings highlight the importance of local membrane translocation of syntaxin-4 for spatial epithelial-mesenchymal transition in the epithelia and provide new mechanistic insights into asymmetric epithelial morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUA6;Q5SUA8;Q5SUA9;Q8CFL1", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0006605 protein targeting;GO:0006974 DNA damage response;GO:0050821 protein stabilization;GO:0008286 insulin receptor signaling pathway;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WV89-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D517-1", "uniprot_id": [ { "id": "PLCC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D517", "type": "external" } ], "mass": 43296.0, "length": 376, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase gamma", "gene_name": "Agpat3", "organism": "Mouse", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a", "refseq_ac": [ { "id": "NP_443747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443747", "type": "external" } ], "gene_names_uniprotkb": "Agpat3; Lpaat3", "gene_names_refseq": "Agpat3; D10Jhu12e; lpaat3", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; 1-AGP acyltransferase 3; 1-AGPAT 3; 1-acylglycerol-3-phosphate O-acyltransferase 3; 2.3.1.51; LPAAT-gamma; Lysophosphatidic acid acyltransferase gamma", "protein_names_refseq": "1-AGP acyltransferase 3; 1-AGPAT 3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; LPAAT-gamma; lysophosphatidic acid acyltransferase 3; lysophosphatidic acid acyltransferase gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:28169); (R-MMU-1483166); (R-MMU-6811436)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15367102;19114731;21750661;34428180;37453647;37507081;37821758;38717361", "class_list": "", "function": "A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome., [RefSeq, PubMed]; AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice., [RefSeq, PubMed]; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (By similarity). Has a preference for arachidonoyl-CoA as a donor (PubMed:19114731). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (PubMed:19114731)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4B4E7;Q7TT39;Q8BST2", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.121", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D517-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPB0-1", "uniprot_id": [ { "id": "PLPR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPB0", "type": "external" } ], "mass": 76693.0, "length": 716, "protein_name": "Phospholipid phosphatase-related protein type 3", "gene_name": "Plppr3", "organism": "Mouse", "refseq_name": "phospholipid phosphatase-related protein type 3 isoform 2", "refseq_ac": [ { "id": "NP_001164406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164406", "type": "external" } ], "gene_names_uniprotkb": "Plppr3; Kiaa4076; Lppr3; Prg2", "gene_names_refseq": "Lppr3; Plppr3; Prg2", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 3; Inactive phospholipid phosphatase PLPPR3; Lipid phosphate phosphatase-related protein type 3; PRG-2; Plasticity-related gene 2 protein", "protein_names_refseq": "PRG-2; inactive phospholipid phosphatase PLPPR3; lipid phosphate phosphatase-related protein type 3; phospholipid phosphatase-related protein type 3 isoform 2; phospholipid phosphatase-related protein type 3; plasticity related gene 2; plasticity-related gene 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:216152); (R-MMU-419408)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12730698;21183079;21750661;22645316;27744421;32848054;34678516;35822049;40021952;40885482", "class_list": "", "function": "PRG3 emerges as a developmental RasGRF1-dependent conductor of filopodia formation and axonal growth enhancer. PRG3-induced neurites resist brain injury-associated outgrowth inhibitors and contribute to functional recovery after spinal cord lesions., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q4V781;Q68FN2;Q6NZQ9", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TPB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI36-1", "uniprot_id": [ { "id": "PAXI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI36", "type": "external" } ], "mass": 64476.0, "length": 591, "protein_name": "Paxillin", "gene_name": "Pxn", "organism": "Mouse", "refseq_name": "paxillin isoform alpha", "refseq_ac": [ { "id": "NP_035353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035353", "type": "external" } ], "gene_names_uniprotkb": "Pxn", "gene_names_refseq": "Pax; Pxn", "protein_names_uniprotkb": "Paxillin", "protein_names_refseq": "paxillin isoform alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:19303); (R-MMU-180292); (R-MMU-4420097); (R-MMU-445355); (R-MMU-446343); (R-MMU-446388); (R-MMU-8849471)", "pathway_count": 7, "publication_count": 29, "publication_id_list": "10753946;11134073;11799401;11805099;11825902;15592455;16537926;16814769;18034455;18986306;19131326;21183079;21430700;21750661;24863063;26091349;26882347;27140681;28528544;31101859;31141452;31219806;31693433;32782141;33823745;38254202;38326036;38718206;8940124", "class_list": "", "function": "Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion., [UniProtKB, UniProtKB]; ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation. Publication Status: Online-Only, [RefSeq, PubMed]; Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB62;Q3TZQ6;Q8VI37", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0038191 neuropilin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0045766 positive regulation of angiogenesis;GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8VI36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTI8-1", "uniprot_id": [ { "id": "SRRM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTI8", "type": "external" } ], "mass": 294840.0, "length": 2703, "protein_name": "Serine/arginine repetitive matrix protein 2", "gene_name": "Srrm2", "organism": "Mouse", "refseq_name": "serine/arginine repetitive matrix protein 2 isoform 2", "refseq_ac": [ { "id": "NP_780438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780438", "type": "external" } ], "gene_names_uniprotkb": "Srrm2; Kiaa0324", "gene_names_refseq": "5033413A03Rik; SRm300; Srrm2; mKIAA0324", "protein_names_uniprotkb": "Serine/arginine repetitive matrix protein 2", "protein_names_refseq": "serine/arginine repetitive matrix protein 2 isoform 2; serine/arginine repetitive matrix protein 2", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 72 (Disease Ontology:DOID:0061045); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:75956); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;15345747;17114649;17242355;18630941;19131326;19144319;21183079;21750661;23806337;24129315;25153642;25428506;26495903;28135057;29237092;30084848;30779550;31219806;32782141;32848054;34428180;34887587;35820727;35822049;36084651;36852467;37828378;38656788;40021952;40885482;40997131", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]; SRRM2 splicing factor modulates cell fate in early development., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 253, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "E9QNB0;Q3TBY5;Q569P9;Q80U37;Q8K383", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0070742 C2H2 zinc finger domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q8BTI8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGC7-1", "uniprot_id": [ { "id": "SYEP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGC7", "type": "external" } ], "mass": 170079.0, "length": 1512, "protein_name": "Bifunctional glutamate/proline--tRNA ligase", "gene_name": "Eprs1", "organism": "Mouse", "refseq_name": "bifunctional glutamate/proline--tRNA ligase isoform 1", "refseq_ac": [ { "id": "NP_084011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084011", "type": "external" } ], "gene_names_uniprotkb": "Eprs1; Eprs; Qprs", "gene_names_refseq": "2410081F06Rik; 3010002K18Rik; Eprs1; Eprs; Qprs", "protein_names_uniprotkb": "Bifunctional glutamate/proline--tRNA ligase; Bifunctional aminoacyl-tRNA synthetase; GluRS; Glutamyl-tRNA synthetase; ProRS; Prolyl-tRNA synthetase", "protein_names_refseq": "bifunctional aminoacyl-tRNA synthetase; bifunctional glutamate/proline--tRNA ligase isoform 1; bifunctional glutamate/proline--tRNA ligase; glutamine-proline-tRNA synthetase", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 15 (Disease Ontology:DOID:0070398)", "pathway": " (mmu:107508); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "12060739;15592455;21540332;21750661;22645316;23071094;23806337;24788674;25153642;25605945;28178239;28528544;29125738;29187734;31219806;34428180;34887587;36210013;36288343;36852467;37453647;37507081;37828378;38201239;39627609;39927985", "class_list": "", "function": "Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (By similarity). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QKC4;Q3UFJ2;Q4VC16", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.24", "type": "external" } ], "go_molecular_function": "GO:0004827 proline-tRNA ligase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0097225 sperm midpiece", "go_biological_process": "GO:0006433 prolyl-tRNA aminoacylation;GO:0032869 cellular response to insulin stimulus;GO:0017148 negative regulation of translation;GO:0071346 cellular response to type II interferon;GO:0006424 glutamyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8CGC7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A935-1", "uniprot_id": [ { "id": "PRD16_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A935", "type": "external" } ], "mass": 140858.0, "length": 1275, "protein_name": "Histone-lysine N-methyltransferase PRDM16", "gene_name": "Prdm16", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase PRDM16 isoform 3", "refseq_ac": [ { "id": "NP_001277955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277955", "type": "external" } ], "gene_names_uniprotkb": "Prdm16; Kiaa1675; Mel1", "gene_names_refseq": "5730557K01Rik; Prdm16; csp1; mel1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase PRDM16; 2.1.1.367; MDS1/EVI1-like gene 1; PR domain zinc finger protein 16; PR domain-containing protein 16; Transcription factor MEL1", "protein_names_refseq": "MDS1/EVI1-like gene 1; PR domain zinc finger protein 16; PR domain-containing protein 16; histone-lysine N-methyltransferase PRDM16 isoform 3; histone-lysine N-methyltransferase PRDM16; line 27; transcription factor MEL1", "tax_id": 10090, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); dilated cardiomyopathy 1LL (Disease Ontology:DOID:0081157)", "pathway": " (mmu:70673); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "12816872;17467076;17618855;18483224;18719582;19641492;21123942;21750661;22033933;22405074;22939622;23473036;23768516;24196706;24439384;24703692;25578880;25644604;25644605;28930673;29539416;30084848;30893596;33086060;35075301;35978186;40228524", "class_list": "", "function": "PRDM16/MEL1 is a Smad binding protein that may be important for development of orofacial structures through modulation of the TGFbeta signaling pathway., [RefSeq, PubMed]; Transcription regulator that acts both as a histone methyltransferase or chromatin adapter, depending on the context (PubMed:18483224, PubMed:22939622). In the cytoplasm, acts as a histone methyltransferase, which catalyzes monomethylation of 'Lys-9' of free histone H3 (H3K9me1) during translation (PubMed:22939622). Monomethylated histone H3 is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases (SUV39H1 and SUV39H2) use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:22939622). Probably one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). In the nucleus, acts as a key chromatin adapter that mediates differentiation of brown and beige adipocytes, which are specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding (PubMed:17618855, PubMed:18483224, PubMed:18719582, PubMed:19641492, PubMed:21123942, PubMed:22033933, PubMed:22405074, PubMed:24196706, PubMed:24703692, PubMed:28930673, PubMed:30893596). Following recruitment to chromatin by PPARG nuclear receptor, promotes. differentiation of myoblastic precursors into brown adipose cells (PubMed:18719582, PubMed:19641492). Mechanistically, acts by mediating recruitment of (1) EHMT1 histone methyltransferase, thereby inhibiting the expression of white adipose-selective genes or (2) mediator complex, activating genes that are highly expressed in brown adipocytes, such as UCP1, PPARA, and PPARGC1A (PubMed:24196706, PubMed:24703692, PubMed:25644604, PubMed:25644605). Also mediates differentiation of beige adipocytes from white adipose cells following recruitment by PPARG (PubMed:21123942, PubMed:22405074). In addition to adipocyte differentiation, also involved in tolerance to gut microbiota: following recruitment to chromatin by RORgammaT (RORC) in a subset of antigen-presenting cells, promotes differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms (PubMed:40228524). Also required in adult heart to preserve mitochondrial function and inhibit hypertrophy with advanced age (PubMed:33086060)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZD6;Q6PB79;Q7TPF4", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050872 white fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "A2A935-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59222-1", "uniprot_id": [ { "id": "SREC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P59222", "type": "external" } ], "mass": 87871.0, "length": 833, "protein_name": "Scavenger receptor class F member 2", "gene_name": "Scarf2", "organism": "Mouse", "refseq_name": "scavenger receptor class F member 2 precursor", "refseq_ac": [ { "id": "NP_722485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722485", "type": "external" } ], "gene_names_uniprotkb": "Scarf2; Srec2", "gene_names_refseq": "NSR1; SREC-II; SRECRP-1; Scarf2; Scatf1; Srec2; SrecII", "protein_names_uniprotkb": "Scavenger receptor class F member 2; SREC-II; Scavenger receptor expressed by endothelial cells 2 protein", "protein_names_refseq": "scavenger receptor class F member 2 precursor; scavenger receptor expressed by endothelial cells 2 (acetyl LDL receptor like); scavenger receptor type F", "tax_id": 10090, "disease": "Van den Ende-Gupta syndrome (Disease Ontology:DOID:0111699)", "pathway": " (mmu:224024)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12154095;15145948;15371419;15592455;21183079;21750661", "class_list": "", "function": "Binds to SRECI and has a similar tissue distribution pattern, [RefSeq, PubMed]; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL)., [UniProtKB]; Role of scavenger receptor expressed by endothelial cells I (SREC-I) in the uptake of modified lipoproteins as well as in the development of atherosclerosis, [RefSeq, PubMed]; SREC-I is a type F scavenger receptor and an endocytic receptor for calreticulin, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P59222-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84104-1", "uniprot_id": [ { "id": "SRSF3_MOUSE", "url": "https://www.uniprot.org/uniprot/P84104", "type": "external" } ], "mass": 19330.0, "length": 164, "protein_name": "Serine/arginine-rich splicing factor 3", "gene_name": "Srsf3", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 3", "refseq_ac": [ { "id": "NP_038691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038691", "type": "external" } ], "gene_names_uniprotkb": "Srsf3; Sfrs3; Srp20; X16", "gene_names_refseq": "Sfrs3; Srsf3; X16", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 3; Pre-mRNA-splicing factor SRP20; Protein X16; Splicing factor, arginine/serine-rich 3", "protein_names_refseq": "pre-mRNA-splicing factor SRP20; serine/arginine-rich splicing factor 3; splicing factor, arginine/serine-rich 3 (SRp20)", "tax_id": 10090, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (mmu:20383); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10823932;2030943;21750661;25605945;28528544;29799838;30899004;31219806;31361958;36288343;38456794;9154810;9307018", "class_list": "", "function": "Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance., [RefSeq, PubMed]; Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08831;P23152;Q564E9", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043274 phospholipase binding;GO:0070878 primary miRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:1990830 cellular response to leukemia inhibitory factor;GO:0008380 RNA splicing;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P84104-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R000-1", "uniprot_id": [ { "id": "OSTA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R000", "type": "external" } ], "mass": 37759.0, "length": 340, "protein_name": "Organic solute transporter subunit alpha", "gene_name": "Slc51a", "organism": "Mouse", "refseq_name": "organic solute transporter subunit alpha", "refseq_ac": [ { "id": "NP_666044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666044", "type": "external" } ], "gene_names_uniprotkb": "Slc51a; Osta", "gene_names_refseq": "D630035O19Rik; OSTalpha; Osta; Slc51a", "protein_names_uniprotkb": "Organic solute transporter subunit alpha; OST-alpha; Solute carrier family 51 subunit alpha", "protein_names_refseq": "OST-alpha; organic solute transporter alpha; organic solute transporter subunit alpha; solute carrier family 51 subunit alpha", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:106407); (R-MMU-159418)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15563450;16251721;16317684;16357057;16357058;16628672;17650074;18292224;21183079;21750661;22535958;24381083;28455390", "class_list": "", "function": "Co-expression of mouse Ostalpha-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate, [RefSeq, PubMed]; Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB are inactive. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the Ost-alpha/Ost-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:18292224, PubMed:22535958). The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:18292224, PubMed:22535958). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (PubMed:16317684). In the complex, SLC51A/OST-alpha adopts a G protein-coupled receptor fold and constitutes a bile acid recognition site (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; In conclusion, we identified Ost-alpha/Ost-beta as a novel FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-) animals may contribute to increased liver injury in these animals., [RefSeq, PubMed]; OSTalpha and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR-/-, mice, [RefSeq, PubMed]; The selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0032782 bile acid secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R000-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84078-1", "uniprot_id": [ { "id": "ARF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P84078", "type": "external" } ], "mass": 20697.0, "length": 181, "protein_name": "ADP-ribosylation factor 1", "gene_name": "Arf1", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor 1", "refseq_ac": [ { "id": "NP_001123880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123880", "type": "external" } ], "gene_names_uniprotkb": "Arf1", "gene_names_refseq": "Arf1", "protein_names_uniprotkb": "ADP-ribosylation factor 1; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 1", "tax_id": 10090, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (mmu:11840); (R-MMU-1660499); (R-MMU-1660514); (R-MMU-199992); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811438); (R-MMU-9845576)", "pathway_count": 11, "publication_count": 16, "publication_id_list": "11914273;11950392;12376537;12679809;17347647;24788674;27723745;33300544;34428180;36210013;36566324;37392777;37786300;38014604;38227057;8947846", "class_list": "", "function": "A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling, [RefSeq, PubMed]; ARF1 maintains intestinal homeostasis by modulating gut microbiota and stem cell function., [RefSeq, PubMed]; Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity., [RefSeq, PubMed]; Arf1 GTPase Regulates Golgi-Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis., [RefSeq, PubMed]; Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Publication Status: Online-Only, [RefSeq, PubMed]; Small GTPase involved in protein trafficking between different compartments (PubMed:11950392). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (PubMed:36566324). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (PubMed:37392777)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10947;P32889;Q3THZ2;Q3U849;Q3UDG1;Q3UF76", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0019003 GDP binding;GO:1990583 phospholipase D activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006886 intracellular protein transport;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0060292 long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P84078-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2X8-1", "uniprot_id": [ { "id": "KEAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2X8", "type": "external" } ], "mass": 69553.0, "length": 624, "protein_name": "Kelch-like ECH-associated protein 1", "gene_name": "Keap1", "organism": "Mouse", "refseq_name": "kelch-like ECH-associated protein 1", "refseq_ac": [ { "id": "NP_001103775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103775", "type": "external" } ], "gene_names_uniprotkb": "Keap1; Inrf2; Kiaa0132", "gene_names_refseq": "INRF2; Keap1; mKIAA0132", "protein_names_uniprotkb": "Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2", "protein_names_refseq": "NRF2 cytosolic inhibitor; cytosolic inhibitor of Nrf2; kelch-like ECH-associated protein 1; ring canal protein", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); gallbladder cancer (Disease Ontology:DOID:3121); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:50868); (R-MMU-5689880); (R-MMU-8951664); (R-MMU-9755511); (R-MMU-983168)", "pathway_count": 5, "publication_count": 39, "publication_id_list": "12193649;12682069;14517554;14764894;15282312;15367669;15379550;15581590;16507366;16581765;16790436;17903176;17906641;18268004;20173742;20421418;20495340;20498371;20956331;21750661;22014577;22872234;22872865;24011591;25153642;25428506;26527616;27697860;28380357;28528544;28842501;29590092;30084848;30779550;31219806;32057709;34428180;37828378;9887101", "class_list": "", "function": "Evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:12682069, PubMed:15282312, PubMed:15367669, PubMed:15581590, PubMed:9887101). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:12193649, PubMed:14764894, PubMed:9887101). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:12193649, PubMed:20498371, PubMed:22014577, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20173742, PubMed:20421418, PubMed:24011591). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 25, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U243;Q3U8N7;Q547S3;Q6ZQI6;Q8BQY3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0097718 disordered domain specific binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006979 response to oxidative stress;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q9Z2X8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVG7-1", "uniprot_id": [ { "id": "OSR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVG7", "type": "external" } ], "mass": 29584.0, "length": 266, "protein_name": "Protein odd-skipped-related 1", "gene_name": "Osr1", "organism": "Mouse", "refseq_name": "protein odd-skipped-related 1", "refseq_ac": [ { "id": "NP_035989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035989", "type": "external" } ], "gene_names_uniprotkb": "Osr1; Odd1", "gene_names_refseq": "Odd1; Osr1; Osr", "protein_names_uniprotkb": "Protein odd-skipped-related 1", "protein_names_refseq": "odd-skipped related 1; protein odd-skipped-related 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23967)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10473132;16223478;18804520;20485683;21750661;21907141;24129315;31219806", "class_list": "", "function": "Transcription factor that plays a role in the regulation of embryonic heart and urogenital development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0034763 negative regulation of transmembrane transport;GO:0072180 mesonephric duct morphogenesis;GO:0048389 intermediate mesoderm development;GO:0072111 cell proliferation involved in kidney development;GO:0072143 mesangial cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WVG7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60716-1", "uniprot_id": [ { "id": "P4HA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60716", "type": "external" } ], "mass": 61002.0, "length": 537, "protein_name": "Prolyl 4-hydroxylase subunit alpha-2", "gene_name": "P4ha2", "organism": "Mouse", "refseq_name": "prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001129548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129548", "type": "external" } ], "gene_names_uniprotkb": "P4ha2", "gene_names_refseq": "P4ha2; P4hl", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-2; 1.14.11.2; 4-PH alpha-2; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2", "protein_names_refseq": "4-PH alpha-2; Prolyl 4-hydroxylase alpha IIa subunit; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor; prolyl 4-hydroxylase subunit alpha-2", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:18452)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11606192;21750661;23806337;25428506;30899004;32819558;34428180;36799463;38857058;7753822", "class_list": "", "function": "Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB]; P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases., [RefSeq, PubMed]; P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer., [RefSeq, PubMed]; Superoxide-induced Type I collagen secretion depends on prolyl 4-hydroxylases., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VBU4", "ec_number_list": [ { "id": "1.14.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0016222 procollagen-proline 4-dioxygenase complex", "go_biological_process": "GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60716-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHP7-1", "uniprot_id": [ { "id": "OLM2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHP7", "type": "external" } ], "mass": 76547.0, "length": 681, "protein_name": "Olfactomedin-like protein 2A", "gene_name": "Olfml2a", "organism": "Mouse", "refseq_name": "olfactomedin-like protein 2A precursor", "refseq_ac": [ { "id": "NP_766442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766442", "type": "external" } ], "gene_names_uniprotkb": "Olfml2a", "gene_names_refseq": "4932431K08Rik; Olfml2a; mFLJ00237", "protein_names_uniprotkb": "Olfactomedin-like protein 2A; Photomedin-1", "protein_names_refseq": "olfactomedin-like protein 2A precursor; olfactomedin-like protein 2A; photomedin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241327)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;15836428;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007165 signal transduction;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BHP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG71-1", "uniprot_id": [ { "id": "P3H2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG71", "type": "external" } ], "mass": 80154.0, "length": 703, "protein_name": "Prolyl 3-hydroxylase 2", "gene_name": "P3h2", "organism": "Mouse", "refseq_name": "prolyl 3-hydroxylase 2 precursor", "refseq_ac": [ { "id": "NP_775555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775555", "type": "external" } ], "gene_names_uniprotkb": "P3h2; Leprel1", "gene_names_refseq": "4832416N06; Leprel1; Mlat4; P3h2", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 2; 1.14.11.7; Leprecan-like protein 1", "protein_names_refseq": "leprecan-like protein 1; myxoid liposarcoma associated protein 4; prolyl 3-hydroxylase 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:210530); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15063763;18487197;18798549;19652424;24368846;25645914;33918807;34428180", "class_list": "glycogene", "function": "Altered collagen prolyl 3-hydroxylation is caused by loss of P3H2., [RefSeq, PubMed]; P3H2 is responsible for the hydroxylation of collagen IV, which has the highest 3-hydroxyproline content of all collagens. It is thus possible that P3H2 mutations may lead to a disease with changes in basement membranes., [RefSeq, PubMed]; Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:24368846, PubMed:25645914). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (PubMed:25645914). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that have proline instead of 4-hydroxyproline in the third position (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Prolyl 3-hydroxylation of type IV collagen by P3H2 has an important function preventing maternal platelet aggregation in response to the early developing embryo, [RefSeq, PubMed]; Study found that all 3 mouse Leprecan genes Lepre1, leprel1 and leprel2 are expressed in the notochord; additionally, they are expressed in dorsal root ganglia, limb buds, branchial arches, and developing kidneys., [RefSeq, PubMed]; This report characterizes expression of the P3H1, P3H2 and P3H3 genes in embryonic and adult mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C673", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005604 basement membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0019511 peptidyl-proline hydroxylation;GO:0032963 collagen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CG71-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDG3-1", "uniprot_id": [ { "id": "PARN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDG3", "type": "external" } ], "mass": 71559.0, "length": 624, "protein_name": "Poly(A)-specific ribonuclease PARN", "gene_name": "Parn", "organism": "Mouse", "refseq_name": "poly(A)-specific ribonuclease PARN isoform 1", "refseq_ac": [ { "id": "NP_083037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083037", "type": "external" } ], "gene_names_uniprotkb": "Parn", "gene_names_refseq": "1200003I18Rik; DAN; Parn", "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PARN; 3.1.13.4; Polyadenylate-specific ribonuclease", "protein_names_refseq": "poly(A)-specific ribonuclease PARN isoform 1; poly(A)-specific ribonuclease PARN; polyadenylate-specific ribonuclease", "tax_id": 10090, "disease": "autosomal recessive dyskeratosis congenita 6 (Disease Ontology:DOID:0070024)", "pathway": " (mmu:74108); (R-MMU-429947); (R-MMU-450604)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17242355;18641416;19217398;21183079;21750661;22645316;22956911;24788674;25605945;28528544;31273937", "class_list": "", "function": "3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to leading to microRNAs degradation or snoRNA increased stability (By similarity)., [UniProtKB, UniProtKB]; A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site., [RefSeq, PubMed]; Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models., [RefSeq, PubMed]; Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode., [RefSeq, PubMed]; These data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7N6;Q9DC46", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000495 box H/ACA sno(s)RNA 3'-end processing;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0090669 telomerase RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VDG3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70209-1", "uniprot_id": [ { "id": "PDLI3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70209", "type": "external" } ], "mass": 34300.0, "length": 316, "protein_name": "PDZ and LIM domain protein 3", "gene_name": "Pdlim3", "organism": "Mouse", "refseq_name": "PDZ and LIM domain protein 3 isoform 2", "refseq_ac": [ { "id": "NP_058078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058078", "type": "external" } ], "gene_names_uniprotkb": "Pdlim3", "gene_names_refseq": "ALP; Actn2lp; Pdlim3", "protein_names_uniprotkb": "PDZ and LIM domain protein 3; Actinin-associated LIM protein; Alpha-actinin-2-associated LIM protein", "protein_names_refseq": "PDZ and LIM domain protein 3 isoform 2; PDZ and LIM domain protein 3; actinin alpha 2 associated LIM protein", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431)", "pathway": " (mmu:53318)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15084604;15663004;21750661;24129315;30084848;39927985;9334352", "class_list": "", "function": "May play a role in the organization of actin filament arrays within muscle cells., [UniProtKB, UniProtKB, UniProtKB]; ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0008092 cytoskeletal protein binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0007015 actin filament organization;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70209-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62011-1", "uniprot_id": [ { "id": "PDPN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62011", "type": "external" } ], "mass": 18233.0, "length": 172, "protein_name": "Podoplanin", "gene_name": "Pdpn", "organism": "Mouse", "refseq_name": "podoplanin isoform 2 precursor", "refseq_ac": [ { "id": "NP_001277751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277751", "type": "external" } ], "gene_names_uniprotkb": "Pdpn; Gp38; Ots8", "gene_names_refseq": "E11; Gp38; OTS-8; Pdpn; RANDAM-2; T1-alpha; T1alpha; T1a", "protein_names_uniprotkb": "Podoplanin; E11; Glycoprotein 38; Gp38; OTS-8; PA2.26 antigen; Transmembrane glycoprotein E11", "protein_names_refseq": "PA2.26 antigen; aggrus; glycoprotein 38; podoplanin isoform 2 precursor; transmembrane glycoprotein E11", "tax_id": 10090, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); oligohydramnios (Disease Ontology:DOID:12215); nephrosis (Disease Ontology:DOID:2527); glioblastoma (Disease Ontology:DOID:3068); germinoma (Disease Ontology:DOID:3304); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:14726); (R-MMU-114604)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10574709;12032185;12654292;1402691;14522983;15231832;17616532;20110424;20479270;20721622;2088477;20962267;21750661;23530051;25347465;28179430;32386302", "class_list": "", "function": "Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:20110424). Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (By similarity). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (PubMed:25347465). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix (By similarity). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:10574709). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (By similarity). Required for normal lung cell proliferation and alveolus formation at birth (PubMed:12654292). Does not function as a water channel or as a regulator of aquaporin-type water channels (By similarity). Does not have any effect on folic acid or amino acid transport (PubMed:12032185)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 0, "predicted_o_glycosites": 17, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2A8J3;Q546R8;Q61612", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051087 protein-folding chaperone binding;GO:0019956 chemokine binding", "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0060838 lymphatic endothelial cell fate commitment;GO:1904328 regulation of myofibroblast contraction;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q62011-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100010001000.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VA53-1", "uniprot_id": [ { "id": "PDS5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VA53", "type": "external" } ], "mass": 164419.0, "length": 1446, "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "Pds5b", "organism": "Mouse", "refseq_name": "sister chromatid cohesion protein PDS5 homolog B isoform 2", "refseq_ac": [ { "id": "NP_001333432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333432", "type": "external" } ], "gene_names_uniprotkb": "Pds5b; Aprin; As3; Kiaa0979", "gene_names_refseq": "AS3; Aprin; Pds5b; Tg(Wap-ERBB2)229Wzw; WAP-Her-2; mKIAA0979", "protein_names_uniprotkb": "Sister chromatid cohesion protein PDS5 homolog B; Androgen-induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff-associated protein AS3", "protein_names_refseq": "Her-2 Tg; PDS5, regulator of cohesion maintenance, homolog B; androgen-induced proliferation inhibitor; androgen-induced prostate proliferative shutoff associated protein AS3; sister chromatid cohesion protein PDS5 homolog B isoform 2; sister chromatid cohesion protein PDS5 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100710); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "15345747;16452087;17242355;17652350;17997301;21183079;21750661;23806337;30084848;30779550;30899004;31219806;34428180;34887587;36210013;36925052;39627609", "class_list": "", "function": "APRIN, in addition to its Pds5 similarity, has the features and localization of a hormone-induced chromatin regulator., [RefSeq, PubMed]; Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A., [RefSeq, PubMed]; Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. GeneRIF: A paper used gene targeting in mice to demonstrate the function of PDS5B in embryonic development., [RefSeq, PubMed]; Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNZ4;Q7TSS4;Q80TM8;Q8BJ18;Q8BLH6;Q8BX77", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0140670 cohesin unloader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0051301 cell division;GO:0007064 mitotic sister chromatid cohesion;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q4VA53-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZE5-1", "uniprot_id": [ { "id": "PAQR8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZE5", "type": "external" } ], "mass": 40430.0, "length": 354, "protein_name": "Membrane progestin receptor beta", "gene_name": "Paqr8", "organism": "Mouse", "refseq_name": "membrane progestin receptor beta", "refseq_ac": [ { "id": "NP_083105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083105", "type": "external" } ], "gene_names_uniprotkb": "Paqr8; Mprb", "gene_names_refseq": "1700019B16Rik; 3110001D06Rik; Paqr8; mPR beta", "protein_names_uniprotkb": "Membrane progestin receptor beta; Lysosomal membrane protein in brain 1; Membrane progesterone P4 receptor beta; Membrane progesterone receptor beta; Progesterone and adipoQ receptor family member 8; Progestin and adipoQ receptor family member 8; Progestin and adipoQ receptor family member VIII; mPR beta", "protein_names_refseq": "lysosomal membrane protein in brain 1; membrane progesterone P4 receptor beta; membrane progesterone receptor beta; membrane progestin receptor beta; progesterone and adipoQ receptor family member 8; progestin and adipoQ receptor family member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:74229)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11676489;12601167;16044242;24269738;35306493;36597146", "class_list": "", "function": "Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice., [RefSeq, PubMed]; PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Publication Status: Online-Only, [RefSeq, PubMed]; Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice., [RefSeq, PubMed]; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway (By similarity). May be involved in oocyte maturation (PubMed:12601167). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHI5;Q8C891;Q8CCW9;Q9DA71", "ec_number_list": [], "go_molecular_function": "GO:0003707 nuclear steroid receptor activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80ZE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSN5-1", "uniprot_id": [ { "id": "PHF23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSN5", "type": "external" } ], "mass": 43547.0, "length": 401, "protein_name": "PHD finger protein 23", "gene_name": "Phf23", "organism": "Mouse", "refseq_name": "PHD finger protein 23 isoform b", "refseq_ac": [ { "id": "NP_001278054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278054", "type": "external" } ], "gene_names_uniprotkb": "Phf23", "gene_names_refseq": "JUNE-1; Phf23", "protein_names_uniprotkb": "PHD finger protein 23; PDH-containing protein JUNE-1", "protein_names_refseq": "PHD finger protein 23 isoform b; PHD zinc finger containing protein JUNE1; novel PHD-finger protein JUNE1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78246)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24535671", "class_list": "", "function": "Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria., [UniProtKB, UniProtKB]; Data show that NP23 and NJL belong to a subset of chromatin-modifying fusion oncoproteins causing leukemia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCH1;Q8BT31;Q8CDY2;Q8CIA4;Q8CIU8;Q8CIU9;Q9CWC8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0006914 autophagy;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BSN5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI51-1", "uniprot_id": [ { "id": "PDLI5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI51", "type": "external" } ], "mass": 63299.0, "length": 591, "protein_name": "PDZ and LIM domain protein 5", "gene_name": "Pdlim5", "organism": "Mouse", "refseq_name": "PDZ and LIM domain protein 5 isoform ENH1e", "refseq_ac": [ { "id": "NP_001177781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177781", "type": "external" } ], "gene_names_uniprotkb": "Pdlim5; Enh", "gene_names_refseq": "1110001A05Rik; Enh1; Enh2; Enh3; Enh; LIM; Pdlim5", "protein_names_uniprotkb": "PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein", "protein_names_refseq": "PDZ and LIM domain protein 5 isoform ENH1e; PDZ and LIM domain protein 5; enigma homolog; enigma-like PDZ and LIM domains protein", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:56376)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10833443;15555569;15946664;16452087;17242355;20097676;20538684;21183079;21750661;22517741;23806337;25153642;25428506;26192747;28528544;29237092;30016717;30059200;30084848;30779550;31599954;32782141;32848054;34428180;35820727;35822049;36288343;36852467;37453647;37507081;39927985;40021952;40885482;40997131", "class_list": "", "function": "Antagonistic splice variants of enigma may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy., [RefSeq, PubMed]; Deletion of ENH leads to destabilization of this protein complex and dilated cardiomyopathy in mice., [RefSeq, PubMed]; May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation., [UniProtKB, UniProtKB]; These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation., [RefSeq, PubMed]; Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGD0;Q9QYN0;Q9QYN1;Q9QYN2", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding;GO:0042805 actinin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061049 cell growth involved in cardiac muscle cell development;GO:0051963 regulation of synapse assembly;GO:0061001 regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q8CI51-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WB2-1", "uniprot_id": [ { "id": "PLPP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WB2", "type": "external" } ], "mass": 29710.0, "length": 271, "protein_name": "Inactive phospholipid phosphatase 7", "gene_name": "Plpp7", "organism": "Mouse", "refseq_name": "inactive phospholipid phosphatase 7 isoform 1", "refseq_ac": [ { "id": "NP_663496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663496", "type": "external" } ], "gene_names_uniprotkb": "Plpp7; Net39; Ppapdc3", "gene_names_refseq": "D830019K17Rik; NET39; Plpp7; Ppapdc3", "protein_names_uniprotkb": "Inactive phospholipid phosphatase 7; Nuclear envelope transmembrane protein 39; Phosphatidic acid phosphatase type 2 domain-containing protein 3", "protein_names_refseq": "inactive phospholipid phosphatase 7 isoform 1; inactive phospholipid phosphatase 7; nuclear envelope transmembrane protein 39; phosphatidic acid phosphatase type 2 domain containing 3; phosphatidic acid phosphatase type 2 domain-containing protein 3; probable lipid phosphate phosphatase PPAPDC3", "tax_id": 10090, "disease": "", "pathway": " (mmu:227721)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17062158;19704009;21183079;21750661;25428506;27264872;30084848;33514739;34428180;37395273", "class_list": "", "function": "Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis., [UniProtKB, PubMed]; The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Publication Status: Online-Only, [RefSeq, PubMed]; The nuclear lamina-associated nuclear envelope transmembrane protein NET39 (Ppapdc3) functions as a negative regulator of myoblast differentiation., [RefSeq, PubMed]; Three muscle-specific nuclear membrane proteins, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate their repression during myogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010832 negative regulation of myotube differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91WB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08709-1", "uniprot_id": [ { "id": "PRDX6_MOUSE", "url": "https://www.uniprot.org/uniprot/O08709", "type": "external" } ], "mass": 24871.0, "length": 224, "protein_name": "Peroxiredoxin-6", "gene_name": "Prdx6", "organism": "Mouse", "refseq_name": "peroxiredoxin-6 isoform 1", "refseq_ac": [ { "id": "NP_031479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031479", "type": "external" } ], "gene_names_uniprotkb": "Prdx6; Aop2; Ltw4; Prdx5", "gene_names_refseq": "1-Cys Prx; 1-cysPrx; 9430088D19Rik; Aop2; Brp-12; CP-3; GPx; LPCAT-5; Ltw-4; Ltw4; Lvtw-4; NSGPx; ORF06; Prdx5; Prdx6; aiPLA2", "protein_names_uniprotkb": "Peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 1.11.1.27; 2.3.1.23; 3.1.1.4; Acidic calcium-independent phospholipase A2; Antioxidant protein 2; Glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; Lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; NSGPx; Non-selenium glutathione peroxidase; aiPLA2", "protein_names_refseq": "1-Cys peroxiredoxin; LPC acyltransferase 5; acidic calcium-independent phospholipase A2; anti-oxidant protein 2, related sequence 3; antioxidant protein 2; glutathione-dependent peroxiredoxin; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; peroxiredoxin 5, related sequence 3; peroxiredoxin 6, related sequence 3; peroxiredoxin-6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11758); (R-MMU-3299685); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10395907;14988405;18034455;21183079;21606357;21750661;23806337;25428506;25605945;26830860;31219806;34428180;34678516;36288343;37453647;37507081;39927985;9205120;9291135", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Has phospholipase activity (PubMed:26830860). Can either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91WT2;Q9QWP4;Q9QWW0", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.121", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0004623 phospholipase A2 activity;GO:0051920 peroxiredoxin activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006979 response to oxidative stress;GO:0046475 glycerophospholipid catabolic process;GO:0000302 response to reactive oxygen species;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O08709-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJT4-1", "uniprot_id": [ { "id": "PNISR_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJT4", "type": "external" } ], "mass": 92115.0, "length": 805, "protein_name": "Arginine/serine-rich protein PNISR", "gene_name": "Pnisr", "organism": "Mouse", "refseq_name": "arginine/serine-rich protein PNISR isoform 2", "refseq_ac": [ { "id": "NP_001356118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001356118", "type": "external" } ], "gene_names_uniprotkb": "Pnisr; Sfrs18; Srrp130", "gene_names_refseq": "5730406M06Rik; Pinsr; Pnisr; Sfrs18; Srsf18", "protein_names_uniprotkb": "Arginine/serine-rich protein PNISR; SRrp130; Serine/arginine-rich-splicing regulatory protein 130; Splicing factor, arginine/serine-rich 130; Splicing factor, arginine/serine-rich 18", "protein_names_refseq": "SRrp130; arginine/serine-rich protein PNISR isoform 2; arginine/serine-rich protein PNISR; serine/arginine-rich splicing factor 18; serine/arginine-rich-splicing regulatory protein 130; splicing factor, arginine/serine-rich 130; splicing factor, arginine/serine-rich 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:66625)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;31219806;34428180;39627609", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9CS92", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0048786 presynaptic active zone", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2AJT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K51-1", "uniprot_id": [ { "id": "PLST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K51", "type": "external" } ], "mass": 70742.0, "length": 630, "protein_name": "Plastin-3", "gene_name": "Pls3", "organism": "Mouse", "refseq_name": "plastin-3 isoform 1", "refseq_ac": [ { "id": "NP_001159925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159925", "type": "external" } ], "gene_names_uniprotkb": "Pls3", "gene_names_refseq": "Pls3", "protein_names_uniprotkb": "Plastin-3; T-plastin", "protein_names_refseq": "T-fimbrin; T-plastin; plastin 3, T; plastin-3 isoform 1; plastin-3", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476); Huntington's disease (Disease Ontology:DOID:12858); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (mmu:102866)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;28135057;28528544;30779550;33649389;34428180;35820727;36288343;37453647;37507081;37751738", "class_list": "", "function": "Actin-bundling protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1AX56;Q3TUZ5", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0098699 structural constituent of presynaptic actin cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0060348 bone development;GO:0051639 actin filament network formation;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99K51-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88531-1", "uniprot_id": [ { "id": "PPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88531", "type": "external" } ], "mass": 34490.0, "length": 306, "protein_name": "Palmitoyl-protein thioesterase 1", "gene_name": "Ppt1", "organism": "Mouse", "refseq_name": "palmitoyl-protein thioesterase 1 precursor", "refseq_ac": [ { "id": "NP_032943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032943", "type": "external" } ], "gene_names_uniprotkb": "Ppt1; Cln1; Ppt", "gene_names_refseq": "9530043G02Rik; CLN1; D4Ertd184e; INCL; PPT; Ppt1", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase 1; 3.1.2.22; 3.1.2.2; PPT-1; Palmitoyl-protein hydrolase 1", "protein_names_refseq": "PPT-1; palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase 1 precursor", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 1 (Disease Ontology:DOID:0110721); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:19063); (R-MMU-75105)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10231585;11717424;19941651;21750661;26495903;26740625;30899004;34428180;40885482;9685319", "class_list": "", "function": "Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins. In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9D681;Q9WTY3", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0019834 phospholipase A2 inhibitor activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0035727 lysophosphatidic acid binding;GO:0120146 sulfatide binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031579 membrane raft organization;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0008306 associative learning;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O88531-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR73-1", "uniprot_id": [ { "id": "PNRC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR73", "type": "external" } ], "mass": 15401.0, "length": 140, "protein_name": "Proline-rich nuclear receptor coactivator 2", "gene_name": "Pnrc2", "organism": "Mouse", "refseq_name": "proline-rich nuclear receptor coactivator 2", "refseq_ac": [ { "id": "NP_080659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080659", "type": "external" } ], "gene_names_uniprotkb": "Pnrc2", "gene_names_refseq": "0610011E17Rik; D4Bwg0593e; Pnrc2", "protein_names_uniprotkb": "Proline-rich nuclear receptor coactivator 2", "protein_names_refseq": "proline-rich nuclear receptor coactivator 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52830); (R-MMU-975957)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16181749;17971453;21750661", "class_list": "", "function": "Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (By similarity). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (By similarity). Required for UPF1/RENT1 localization to the P-body (By similarity). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (PubMed:17971453)., [UniProtKB, UniProtKB, PubMed]; Study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases., [RefSeq, PubMed]; The finding that the PNRC2 promoter is activated by NFY and repressed by E2F1 indicates that in addition to functioning as nuclear receptor coactivator, PNRC2 may also play a role in the cell cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AV48;B1AV49;Q9CXC6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0000932 P-body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CR73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53351-1", "uniprot_id": [ { "id": "PLK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P53351", "type": "external" } ], "mass": 77812.0, "length": 682, "protein_name": "Serine/threonine-protein kinase PLK2", "gene_name": "Plk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PLK2", "refseq_ac": [ { "id": "NP_690017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690017", "type": "external" } ], "gene_names_uniprotkb": "Plk2; Snk", "gene_names_refseq": "Plk2; Snk", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK2; 2.7.11.21; PLK-2; Polo-like kinase 2; Serine/threonine-protein kinase SNK; Serum-inducible kinase", "protein_names_refseq": "PLK-2; serine/threonine-protein kinase PLK2; serine/threonine-protein kinase SNK; serum-inducible kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:20620); (R-MMU-6804115)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12651910;12897130;12972611;1508211;16479539;19004816;21382555;31219806;34428180;35820727;35842499;36210013;37094847;37828378;39383034", "class_list": "", "function": "CIB co-immunoprecipitated with Snk and inhibited the kinase activity of Snk, suggesting that CIB is a negative regulator for Snk kinase activity., [RefSeq, PubMed]; Embryos of Plk2(Snk)-deficient mice show retarded growth and skeletal development late in gestation., [RefSeq, PubMed]; Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21[cip1] signaling in acute kidney injury., [RefSeq, PubMed]; Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular Matrix Accumulation, and Oxidative Stress of Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling., [RefSeq, PubMed]; Polo-like kinase 2 promotes microglial activation via regulation of the HSP90alpha/IKKbeta pathway., [RefSeq, PubMed]; There is a mitotic checkpoint wherein p53-dependent activation of Snk/Plk2 prevents mitotic catastrophe following spindle damage, [RefSeq, PubMed]; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0007613 memory;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53351-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SWZ9-1", "uniprot_id": [ { "id": "PLD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SWZ9", "type": "external" } ], "mass": 25041.0, "length": 221, "protein_name": "Mitochondrial cardiolipin hydrolase", "gene_name": "Pld6", "organism": "Mouse", "refseq_name": "mitochondrial cardiolipin hydrolase isoform a", "refseq_ac": [ { "id": "NP_001277212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277212", "type": "external" } ], "gene_names_uniprotkb": "Pld6", "gene_names_refseq": "4933433K01Rik; Gm10; Pld6; Zuc; mZuc; mitoPLD", "protein_names_uniprotkb": "Mitochondrial cardiolipin hydrolase; 3.1.4.-; Choline phosphatase 6; MitoPLD; Mitochondrial phospholipase; PLD6; Phosphatidylcholine-hydrolyzing phospholipase D6; Phospholipase D6; Protein zucchini homolog; mZuc", "protein_names_refseq": "choline phosphatase 6; mitochondrial cardiolipin hydrolase isoform a; mitochondrial cardiolipin hydrolase; mitochondrial phospholipase; novel Phospholipase D Active site motif-containing protein; phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D6; protein zucchini homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:194908); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "21397847;21397848;22281006;23064227;23064230;25428506;25762440;26678338;28115634;28749988;28852571;29113556;31996847;33783608", "class_list": "", "function": "Crystal structure of mZuc at 1.75 A resolution indicates greater architectural similarity to phospholipase-D family nucleases than to phospholipases; data suggest that the Zucchini proteins act in primary piRNA biogenesis as nucleases, perhaps generating the 5' ends of primary piRNAs., [RefSeq, PubMed]; Data suggest that mitochondrial-surface phosphatidic acid generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production., [RefSeq, PubMed]; MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (or ZUCCHINI or MITOPLD), a mitochondrial nuclease/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type., [RefSeq, PubMed]; MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. Review article, [RefSeq, PubMed]; PLD6 is a surface marker of undifferentiated spermatogonia in testes., [RefSeq, PubMed]; Pre-piRNAs are generated by parallel Zucchini-dependent and -independent mechanisms; cleavage by Zucchini occurs at previously unrecognized consensus motifs on pre-pre-piRNAs, requires the RNA helicase Armitage, and is accompanied by 2'-O-methylation of pre-piRNAs, [RefSeq, PubMed]; Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (By similarity). Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation (PubMed:21397848). Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation (PubMed:26678338). The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis (PubMed:21397847, PubMed:21397848). Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA) (PubMed:21397847, PubMed:23064227, PubMed:23064230). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (PubMed:23064227, PubMed:23064230). PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs (PubMed:21397847). Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (PubMed:33783608)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results indicate a conserved role for MITOPLD/Zuc in the piRNA pathway and link mitochondrial membrane metabolism/signaling to small RNA biogenesis., [RefSeq, PubMed]; The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN71;Q3UTA3;Q8BVM0", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035755 cardiolipin hydrolase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0030719 P granule organization;GO:0016042 lipid catabolic process;GO:0007286 spermatid development;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5SWZ9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ52-1", "uniprot_id": [ { "id": "PLPR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ52", "type": "external" } ], "mass": 35388.0, "length": 321, "protein_name": "Phospholipid phosphatase-related protein type 5", "gene_name": "Plppr5", "organism": "Mouse", "refseq_name": "phospholipid phosphatase-related protein type 5 isoform 1", "refseq_ac": [ { "id": "NP_001292380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292380", "type": "external" } ], "gene_names_uniprotkb": "Plppr5; Lppr5", "gene_names_refseq": "4833424O15Rik; Lppr5; PRG-5; Pap2d; Plppr5", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 5; Lipid phosphate phosphatase-related protein type 5; PRG-5; Plasticity-related gene 5 protein", "protein_names_refseq": "lipid phosphate phosphatase-related protein type 5; phosphatidic acid phosphatase type 2d; phospholipid phosphatase-related protein type 5 isoform 1; phospholipid phosphatase-related protein type 5; plasticity-related gene 5 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75769); (R-MMU-419408)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20032306;21750661;25074937;33692754", "class_list": "", "function": "Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation., [RefSeq, PubMed]; Data show that PRG5 induces filopodia growth independently of Cdc42, and that axon collapse and RhoA activation induced by LPA and myelin-associated neurite inhibitor Nogo-A is attenuated in the presence of PRG5., [RefSeq, PubMed]; Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice. Erratum:[Front Endocrinol (Lausanne). 2022 Mar 14;13:879685. doi: 10.3389/fendo.2022.879685. PMID: 35370970] Publication Status: Online-Only, [RefSeq, PubMed]; Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIL7;Q8K0B6;Q9D606", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0051491 positive regulation of filopodium assembly;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BJ52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C767-1", "uniprot_id": [ { "id": "PPR3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C767", "type": "external" } ], "mass": 32433.0, "length": 284, "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "Ppp1r3b", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 3B", "refseq_ac": [ { "id": "NP_808409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808409", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3b; Ppp1r4", "gene_names_refseq": "6430576E21; GL; PTG; Ppp1r3b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3B; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; PP1 subunit R4; PTG; Protein phosphatase 1 regulatory subunit 4; Protein phosphatase 1 subunit GL", "protein_names_refseq": "PP1 subunit R4; hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; protein phosphatase 1 regulatory subunit 3B; protein phosphatase 1 regulatory subunit 4; protein phosphatase 1, regulatory (inhibitor) subunit 3B", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:244416)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11872655;16949035;21183079;29266543;38290087", "class_list": "glycogene", "function": "Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity)., [UniProtKB]; Analysis of expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells, [RefSeq, PubMed]; MTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b. Publication Status: Online-Only, [RefSeq, PubMed]; Mice lacking protein phosphatase 1 regulatory subunit 3B (PPP1R3B) were deficient in hepatic glycogen, whereas HTGC was unchanged. Hepatic overexpression of PPP1R3B caused accumulation of hepatic glycogen and elevated plasma levels of ALT, but did not change HTGC, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAJ7", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding;GO:0050196 [phosphorylase] phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0042587 glycogen granule", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0045818 negative regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C767-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET66-1", "uniprot_id": [ { "id": "PI16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET66", "type": "external" } ], "mass": 53650.0, "length": 498, "protein_name": "Peptidase inhibitor 16", "gene_name": "Pi16", "organism": "Mouse", "refseq_name": "peptidase inhibitor 16 precursor", "refseq_ac": [ { "id": "NP_076223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076223", "type": "external" } ], "gene_names_uniprotkb": "Pi16; Cripi", "gene_names_refseq": "1200009H11Rik; Cripi; PI-16; Pi16", "protein_names_uniprotkb": "Peptidase inhibitor 16; Cysteine-rich protease inhibitor; PI-16", "protein_names_refseq": "cysteine-rich protease inhibitor; peptidase inhibitor 16 precursor; protease inhibitor 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:74116)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17909105;21750661;27539859;32079726;32227584;38147957;38566233", "class_list": "", "function": "May inhibit cardiomyocyte growth., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Our data indicate that PI16 suppresses chemerin activation in the myocardium and suggest that this circuit may be part of the cardiac stress response., [RefSeq, PubMed]; Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts., [RefSeq, PubMed]; PI16, a novel protein secreted from the heart, is strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo, [RefSeq, PubMed]; Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells., [RefSeq, PubMed]; Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function. Publication Status: Online-Only, [RefSeq, PubMed]; These findings support a model in which PI16 promotes neuropathic pain by mediating a cross-talk between fibroblasts and the endothelial barrier leading to barrier opening, cellular influx, and increased pain, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q148Q6;Q8CHU4;Q9JJ56", "ec_number_list": [], "go_molecular_function": "GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ET66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0M4-1", "uniprot_id": [ { "id": "PODXL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0M4", "type": "external" } ], "mass": 53389.0, "length": 503, "protein_name": "Podocalyxin", "gene_name": "Podxl", "organism": "Mouse", "refseq_name": "podocalyxin precursor", "refseq_ac": [ { "id": "NP_038751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038751", "type": "external" } ], "gene_names_uniprotkb": "Podxl; Pclp1", "gene_names_refseq": "Ly102; PCLP-1; PC; Pclp1; Podxl1; Podxl", "protein_names_uniprotkb": "Podocalyxin; PCLP-1; PC; Podocalyxin-like protein 1", "protein_names_refseq": "podocalyxin precursor; podocalyxin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27205)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10591182;11435469;17311105;21183079;34428180", "class_list": "", "function": "Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells., [UniProtKB, PubMed, PubMed]; Podocalyxin is required for normal kidney function, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESZ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0072175 epithelial tube formation;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0M4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB77-1", "uniprot_id": [ { "id": "QCR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB77", "type": "external" } ], "mass": 48235.0, "length": 453, "protein_name": "Cytochrome b-c1 complex subunit 2, mitochondrial", "gene_name": "Uqcrc2", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080175", "type": "external" } ], "gene_names_uniprotkb": "Uqcrc2", "gene_names_refseq": "1500004O06Rik; Uqcrc2", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2", "protein_names_refseq": "complex III subunit 2; core protein II; cytochrome b-c1 complex subunit 2, mitochondrial precursor; cytochrome b-c1 complex subunit 2, mitochondrial; ubiquinol-cytochrome-c reductase complex core protein 2", "tax_id": 10090, "disease": "chromosome 16p12.1 deletion syndrome (Disease Ontology:DOID:0060399); mitochondrial complex III deficiency nuclear type 5 (Disease Ontology:DOID:0080114)", "pathway": " (mmu:67003); (R-MMU-611105); (R-MMU-9837999); (R-MMU-9865881)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;19026783;21750661;23576753;26495903;30666338;31219806;31536960;33300544;34428180;34616041;36288343;37453647;37507081;37828378;38575788;39627609;39927985", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34616041, PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:34616041, PubMed:38575788). The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol (PubMed:34616041, PubMed:38575788). In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK11;Q9CVK7", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006508 proteolysis;GO:0009410 response to xenobiotic stimulus;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9DB77-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56371-1", "uniprot_id": [ { "id": "RAB4A_MOUSE", "url": "https://www.uniprot.org/uniprot/P56371", "type": "external" } ], "mass": 24409.0, "length": 218, "protein_name": "Ras-related protein Rab-4A", "gene_name": "Rab4a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-4A", "refseq_ac": [ { "id": "NP_033029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033029", "type": "external" } ], "gene_names_uniprotkb": "Rab4a; Rab4", "gene_names_refseq": "Rab4a; Rab4", "protein_names_uniprotkb": "Ras-related protein Rab-4A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:19341); (R-MMU-1660499); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8875656)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11172003;14697203;16923123;17509819;20048159;20098723;21750661;38519468;8950022", "class_list": "", "function": "Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14697203). RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSQ6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P56371-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62823-1", "uniprot_id": [ { "id": "RAB3C_MOUSE", "url": "https://www.uniprot.org/uniprot/P62823", "type": "external" } ], "mass": 25872.0, "length": 227, "protein_name": "Ras-related protein Rab-3C", "gene_name": "Rab3c", "organism": "Mouse", "refseq_name": "ras-related protein Rab-3C isoform 1", "refseq_ac": [ { "id": "NP_076341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076341", "type": "external" } ], "gene_names_uniprotkb": "Rab3c", "gene_names_refseq": "2700062I01Rik; 3110015B08Rik; 3110037E15Rik; Rab3c", "protein_names_uniprotkb": "Ras-related protein Rab-3C; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3C isoform 1; ras-related protein Rab-3C; small GTP-binding protein Rab3C", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:67295); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12578829;18849981;21183079;21750661;29125462;33300544", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62858;Q62974;Q63482;Q9CXQ1", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031982 vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0019882 antigen processing and presentation;GO:0017157 regulation of exocytosis;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62823-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2X2-1", "uniprot_id": [ { "id": "PSD10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2X2", "type": "external" } ], "mass": 25084.0, "length": 231, "protein_name": "26S proteasome non-ATPase regulatory subunit 10", "gene_name": "Psmd10", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 10 isoform 2", "refseq_ac": [ { "id": "NP_001157649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157649", "type": "external" } ], "gene_names_uniprotkb": "Psmd10", "gene_names_refseq": "Psmd10", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; Gankyrin", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 10 isoform 2; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; gankyrin; proteasome subunit p28; proteosome (prosome, macropain) 26S subunit, non-ATPase, 10; proteosome subunit p28", "tax_id": 10090, "disease": "", "pathway": " (mmu:53380); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17292836;17896003;17935131;20628200;21750661;22574218;23376718;25153642;30109252;30513515;37507081", "class_list": "glycogene", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis., [UniProtKB, PubMed]; Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity)., [UniProtKB]; Findings suggest that retinoblastoma protein degradation in Lmna-/- cells occurs by gankyrin and MDM2-independent mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Gankyrin oncoprotein has a role in progression of esophageal squamous cell carcinoma, [RefSeq, PubMed]; Study in APC and/or gankyrin-deficient mice revealed that gankyrin in epithelial cell contributes to the development of sporadic colorectal cancer by reducing the expression of c-Myc, a critical mediator of the APC signaling pathway, and interleukin-6., [RefSeq, PubMed]; The present study clarified, at least partly, mechanisms of vascular tumorigenesis, and suggests that gankyrin might play a physiological role in hypoxic responses besides its roles as an oncoprotein., [RefSeq, PubMed]; These studies show that Gank protein promotes hepatocyte proliferation by elimination of tumor-suppressor proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0G2;Q9D383;Q9D7N8", "ec_number_list": [], "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z2X2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35292-1", "uniprot_id": [ { "id": "RAB17_MOUSE", "url": "https://www.uniprot.org/uniprot/P35292", "type": "external" } ], "mass": 23640.0, "length": 214, "protein_name": "Ras-related protein Rab-17", "gene_name": "Rab17", "organism": "Mouse", "refseq_name": "ras-related protein Rab-17", "refseq_ac": [ { "id": "NP_001153197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153197", "type": "external" } ], "gene_names_uniprotkb": "Rab17", "gene_names_refseq": "Rab17", "protein_names_uniprotkb": "Ras-related protein Rab-17; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-17", "tax_id": 10090, "disease": "", "pathway": " (mmu:19329); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1555775;21183079;21291502;21750661;22291024;25428506;26957544;8486736;9490718;9624171", "class_list": "", "function": "The selectivity in syntaxin binding and apical protein redistribution further suggests that rab17 and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates, for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface (PubMed:9624171). Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis (PubMed:9490718). Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (PubMed:21291502, PubMed:22291024). May also play a role in cell migration (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921D2;Q9D723", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;GO:0006886 intracellular protein transport;GO:0046847 filopodium assembly;GO:0060271 cilium assembly;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35292-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63011-1", "uniprot_id": [ { "id": "RAB3A_MOUSE", "url": "https://www.uniprot.org/uniprot/P63011", "type": "external" } ], "mass": 24970.0, "length": 220, "protein_name": "Ras-related protein Rab-3A", "gene_name": "Rab3a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-3A", "refseq_ac": [ { "id": "NP_001159871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159871", "type": "external" } ], "gene_names_uniprotkb": "Rab3a", "gene_names_refseq": "Rab3a", "protein_names_uniprotkb": "Ras-related protein Rab-3A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3A", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:19339); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-6798695); (R-MMU-8873719); (R-MMU-8876198); (R-MMU-888590)", "pathway_count": 10, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11056535;11431472;11598194;12401793;12578829;12590134;15159548;17509819;18849981;20674857;21183079;21750661;29125462;31651360;32848054;33300544;34180342;34428180;34645086;36210013;40885482;7687127", "class_list": "", "function": "Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein., [RefSeq, PubMed]; TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:11598194). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 isoform RIMS2 and RPH3AL effectors in pancreatic beta cells (PubMed:15159548, PubMed:20674857). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P05713;Q3TSL4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0051021 GDP-dissociation inhibitor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0097091 synaptic vesicle clustering;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0048790 maintenance of presynaptic active zone structure;GO:0050975 sensory perception of touch", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P63011-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDM4-1", "uniprot_id": [ { "id": "PSMD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDM4", "type": "external" } ], "mass": 100203.0, "length": 908, "protein_name": "26S proteasome non-ATPase regulatory subunit 2", "gene_name": "Psmd2", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 2", "refseq_ac": [ { "id": "NP_598862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598862", "type": "external" } ], "gene_names_uniprotkb": "Psmd2", "gene_names_refseq": "9430095H01Rik; Psmd2; TEG-190; Tex190", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; testis expressed gene 190", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:21762); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 24, "publication_id_list": "16857966;17242355;19131326;21183079;21750661;21952136;23806337;25153642;25428506;25605945;26150391;28315936;28528544;29187734;30084848;30500822;30779550;33300544;34428180;36288343;37453647;37828378;39627609;39927985", "class_list": "", "function": "Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1., [UniProtKB, UniProtKB]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8VDM4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35955-1", "uniprot_id": [ { "id": "PSB10_MOUSE", "url": "https://www.uniprot.org/uniprot/O35955", "type": "external" } ], "mass": 29063.0, "length": 273, "protein_name": "Proteasome subunit beta type-10", "gene_name": "Psmb10", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-10", "refseq_ac": [ { "id": "NP_038668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038668", "type": "external" } ], "gene_names_uniprotkb": "Psmb10; Lmp10; Mecl1", "gene_names_refseq": "Mecl-1; Mecl1; Psmb10", "protein_names_uniprotkb": "Proteasome subunit beta type-10; 3.4.25.1; Low molecular mass protein 10; Macropain subunit MECl-1; Multicatalytic endopeptidase complex subunit MECl-1; Proteasome MECl-1; Proteasome subunit beta-2i", "protein_names_refseq": "low molecular mass protein 10; macropain subunit MECl-1; multicatalytic endopeptidase complex subunit MECl-1; prosome Mecl1; proteasome (prosomome, macropain) subunit, beta type 10; proteasome MECl-1; proteasome subunit MECL1; proteasome subunit beta type-10; proteasome subunit beta-2i", "tax_id": 10090, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); proteosome-associated autoinflammatory syndrome 5 (Disease Ontology:DOID:0060919); immunodeficiency 121 (Disease Ontology:DOID:0061087)", "pathway": " (mmu:19171); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-9907900); (R-MMU-9912633)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10413086;15907481;16709825;16857966;22341445;23706739;34428180;34547302;9300697;9367687", "class_list": "", "function": "Expression of immunoproteasome subunits in the brains of Toxoplasma gondii-infected mice., [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Plays a role in determining the T-cell repertoire for an antiviral T-cell response., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08687;Q99KC5", "ec_number_list": [ { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0042098 T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35955-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11416-1", "uniprot_id": [ { "id": "RARA_MOUSE", "url": "https://www.uniprot.org/uniprot/P11416", "type": "external" } ], "mass": 50735.0, "length": 462, "protein_name": "Retinoic acid receptor alpha", "gene_name": "Rara", "organism": "Mouse", "refseq_name": "retinoic acid receptor alpha isoform 2", "refseq_ac": [ { "id": "NP_001169999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001169999", "type": "external" } ], "gene_names_uniprotkb": "Rara; Nr1b1", "gene_names_refseq": "Nr1b1; RARalpha1; RAR; Rara", "protein_names_uniprotkb": "Retinoic acid receptor alpha; Nuclear receptor subfamily 1 group B member 1; RAR-alpha", "protein_names_refseq": "RAR alpha 1; RAR-alpha; nuclear receptor subfamily 1 group B member 1; retinoic acid receptor alpha isoform 2", "tax_id": 10090, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324)", "pathway": " (mmu:19401); (R-MMU-383280); (R-MMU-4090294); (R-MMU-5362517); (R-MMU-9616222)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10660575;10788465;12079996;1320576;15901285;17205979;17905941;1846598;19078967;19389355;20078863;2174108;2544807;7476969;8383767;9192892;9230306", "class_list": "", "function": "Receptor for retinoic acid (PubMed:17205979). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:17205979). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:17205979). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:17205979, PubMed:19078967, PubMed:9230306). Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (By similarity). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (PubMed:15901285). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (PubMed:15901285, PubMed:17905941). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (PubMed:10660575, PubMed:17905941). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P22603", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0002068 glandular epithelial cell development;GO:0060010 Sertoli cell fate commitment;GO:0060534 trachea cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P11416-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49722-1", "uniprot_id": [ { "id": "PSA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P49722", "type": "external" } ], "mass": 25927.0, "length": 234, "protein_name": "Proteasome subunit alpha type-2", "gene_name": "Psma2", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-2", "refseq_ac": [ { "id": "NP_032970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032970", "type": "external" } ], "gene_names_uniprotkb": "Psma2; Lmpc3", "gene_names_refseq": "Lmpc3; Psma2", "protein_names_uniprotkb": "Proteasome subunit alpha type-2; Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3; Proteasome subunit alpha-2; alpha-2", "protein_names_refseq": "alpha-2; macropain subunit C3; multicatalytic endopeptidase complex subunit C3; proteasome (prosome, macropain) subunit, alpha type 2; proteasome component C3; proteasome subunit alpha type-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19166); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 59, "publication_count": 18, "publication_id_list": "10436176;16581775;16857966;18034455;21183079;22078707;22341445;23806337;25605945;26495903;26740625;31219806;32069316;32152506;34203471;34428180;36210013;7697131", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q3A4;Q6ZWV8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009615 response to virus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P49722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62821-1", "uniprot_id": [ { "id": "RAB1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P62821", "type": "external" } ], "mass": 22678.0, "length": 205, "protein_name": "Ras-related protein Rab-1A", "gene_name": "Rab1a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-1A", "refseq_ac": [ { "id": "NP_033022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033022", "type": "external" } ], "gene_names_uniprotkb": "Rab1a; Rab1", "gene_names_refseq": "Gtbp; Rab-1; Rab1a; Rab1; Ypt1; mKIAA3012", "protein_names_uniprotkb": "Ras-related protein Rab-1A; 3.6.5.2; YPT1-related protein", "protein_names_refseq": "RAB1, member RAS oncogene family; YPT1-related protein; ras-related YPT1 protein; ras-related protein Rab-1A", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:19324); (R-MMU-162658); (R-MMU-204005); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "19603039;20639577;21750661;22854043;24549040;2506528;31219806;3127202;33300544;34203471;34428180;35984892;36210013;37453647;37828378;39627609;39927985", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:22854043). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:22854043). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (By similarity). Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (PubMed:22854043)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11476;Q3TX44;Q811M4;Q96N61;Q9Y3T2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:1903020 positive regulation of glycoprotein metabolic process;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P62821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSA6-1", "uniprot_id": [ { "id": "PRSR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSA6", "type": "external" } ], "mass": 67263.0, "length": 634, "protein_name": "Proline and serine-rich protein 3", "gene_name": "Proser3", "organism": "Mouse", "refseq_name": "proline and serine-rich protein 3 isoform 2", "refseq_ac": [ { "id": "NP_899144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899144", "type": "external" } ], "gene_names_uniprotkb": "Proser3; BC053749", "gene_names_refseq": "Proser3", "protein_names_uniprotkb": "Proline and serine-rich protein 3", "protein_names_refseq": "proline and serine-rich protein 3 isoform 2; proline and serine-rich protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:333193)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;25428506;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C786", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TSA6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TM6-1", "uniprot_id": [ { "id": "R3HD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TM6", "type": "external" } ], "mass": 114583.0, "length": 1044, "protein_name": "R3H domain-containing protein 2", "gene_name": "R3hdm2", "organism": "Mouse", "refseq_name": "R3H domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001161764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161764", "type": "external" } ], "gene_names_uniprotkb": "R3hdm2; Kiaa1002", "gene_names_refseq": "1300003K24Rik; R3hdm2; mKIAA1002", "protein_names_uniprotkb": "R3H domain-containing protein 2", "protein_names_refseq": "R3H domain-containing protein 2 isoform 1; R3H domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71750)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16452087;21183079;21750661;22645316;31219806;32782141;34428180;36852467;40021952;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80YB1;Q8BLS5;Q9CW50", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q80TM6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812A5-1", "uniprot_id": [ { "id": "PRR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q812A5", "type": "external" } ], "mass": 42523.0, "length": 387, "protein_name": "Proline-rich protein 5", "gene_name": "Prr5", "organism": "Mouse", "refseq_name": "proline-rich protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001333591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333591", "type": "external" } ], "gene_names_uniprotkb": "Prr5; Protor1", "gene_names_refseq": "Arhgap8; C030017C09Rik; Protor-1; Protor1; Prr5", "protein_names_uniprotkb": "Proline-rich protein 5; Protein observed with Rictor-1; Protor-1", "protein_names_refseq": "proline-rich protein 5 isoform 2; proline-rich protein 5; protein observed with Rictor-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:109270); (R-MMU-1257604); (R-MMU-389357); (R-MMU-5218920); (R-MMU-6804757); (R-MMU-9856530)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "12559566;15718101;20801936;21183079", "class_list": "", "function": "Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EAK2;Q8BIE7;Q8BIK1;Q8R1A0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0031932 TORC2 complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q812A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08775-1", "uniprot_id": [ { "id": "RPB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P08775", "type": "external" } ], "mass": 217176.0, "length": 1970, "protein_name": "DNA-directed RNA polymerase II subunit RPB1", "gene_name": "Polr2a", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit RPB1", "refseq_ac": [ { "id": "NP_001277997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277997", "type": "external" } ], "gene_names_uniprotkb": "Polr2a; Rpii215; Rpo2-1", "gene_names_refseq": "220kDa; Polr2a; Rpb1; Rpo2-1", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB1; 2.7.7.48; 2.7.7.6; 3'-5' exoribonuclease; 3.1.13.-; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1", "protein_names_refseq": "3'-5' exoribonuclease; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; RNA polymerase II 1; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1", "tax_id": 10090, "disease": "Cockayne syndrome (Disease Ontology:DOID:2962); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:20020); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 22, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;11030652;1542581;17242355;17526739;18252004;19141475;19144319;20173027;21183079;21750661;22767893;24207025;24968300;25428506;25605945;26687004;29187734;2999785;30084848;3038894;30779550;31219806;32142649;34203471;34418053;34428180;35820727;36210013;37828378;39627609;8692929", "class_list": "", "function": "Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:18252004, PubMed:24207025). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26687004)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]; RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q5F298", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" } ], "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome;GO:0000791 euchromatin", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006353 DNA-templated transcription termination", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P08775-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZS9-1", "uniprot_id": [ { "id": "RM48_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZS9", "type": "external" } ], "mass": 23953.0, "length": 211, "protein_name": "Large ribosomal subunit protein mL48", "gene_name": "Mrpl48", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL48 isoform 1 precursor", "refseq_ac": [ { "id": "NP_942128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942128", "type": "external" } ], "gene_names_uniprotkb": "Mrpl48", "gene_names_refseq": "1810030E20Rik; 2610028L11Rik; CGI-118; D4Ertd786e; L48mt; MRP-L48; Mrpl48", "protein_names_uniprotkb": "Large ribosomal subunit protein mL48; 39S ribosomal protein L48, mitochondrial; L48mt; MRP-L48", "protein_names_refseq": "39S ribosomal protein L48, mitochondrial; large ribosomal subunit protein mL48 isoform 1 precursor; large ribosomal subunit protein mL48", "tax_id": 10090, "disease": "", "pathway": " (mmu:52443); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;23806337;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA35", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JZS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCV4-1", "uniprot_id": [ { "id": "RMD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCV4", "type": "external" } ], "mass": 35000.0, "length": 305, "protein_name": "Regulator of microtubule dynamics protein 1", "gene_name": "Rmdn1", "organism": "Mouse", "refseq_name": "regulator of microtubule dynamics protein 1", "refseq_ac": [ { "id": "NP_079752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079752", "type": "external" } ], "gene_names_uniprotkb": "Rmdn1; Fam82b", "gene_names_refseq": "Fam82b; RMD-1; Rmdn1", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 1; Microtubule-associated protein; Protein FAM82B; RMD-1; mRMD-1", "protein_names_refseq": "family with sequence similarity 82, member B; microtubule-associated protein; regulator of microtubule dynamics protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66302)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18070910;21750661;23806337;37453647;37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AGJ3;A9UN01;Q8C0Y9;Q8R166;Q9CWS6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0097431 mitotic spindle pole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DCV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QAU8-1", "uniprot_id": [ { "id": "ARK2C_MOUSE", "url": "https://www.uniprot.org/uniprot/E9QAU8", "type": "external" } ], "mass": 39736.0, "length": 347, "protein_name": "E3 ubiquitin-protein ligase ARK2C", "gene_name": "Ark2c", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ARK2C", "refseq_ac": [ { "id": "NP_001157976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157976", "type": "external" } ], "gene_names_uniprotkb": "Ark2c; Gm96; Rnf165", "gene_names_refseq": "2900024M11Rik; Akd2; Ark2c; G630064H08Rik; Gm96; Rnf165", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ARK2C; 2.3.2.27; Ark2C; Arkadia-like protein 2C; RING finger protein 165", "protein_names_refseq": "E3 ubiquitin-protein ligase ARK2C; E3 ubiquitin-protein ligase RNF165; arkadia 2; arkadia-like protein 2C; ring finger protein 165", "tax_id": 10090, "disease": "", "pathway": " (mmu:225743)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23610558", "class_list": "", "function": "Ark2C is expressed in the nervous system in mice, and its loss leads to motor neuron axon extension and muscle innervation deficits., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation (PubMed:23610558). Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP (PubMed:23610558). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZA7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060384 innervation;GO:0007409 axonogenesis;GO:0030513 positive regulation of BMP signaling pathway;GO:0060173 limb development;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9QAU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49312-1", "uniprot_id": [ { "id": "ROA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P49312", "type": "external" } ], "mass": 34196.0, "length": 320, "protein_name": "Heterogeneous nuclear ribonucleoprotein A1", "gene_name": "Hnrnpa1", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein A1 isoform a", "refseq_ac": [ { "id": "NP_034577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034577", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa1; Fli-2; Hnrpa1; Tis", "gene_names_refseq": "HDP-1; Hdp; Hnrnpa1; Hnrpa1; hnRNP A1; hnrnp-A1", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A1; HDP-1; Helix-destabilizing protein; Single-strand-binding protein; Topoisomerase-inhibitor suppressed; hnRNP A1; hnRNP core protein A1", "protein_names_refseq": "helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1 isoform a; hnRNP core protein A1; single-strand-binding protein; topoisomerase-inhibitor suppressed", "tax_id": 10090, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); amyotrophic lateral sclerosis type 20 (Disease Ontology:DOID:0060211); distal myopathy 3 (Disease Ontology:DOID:0111189); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 (Disease Ontology:DOID:0111386); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15382); (R-MMU-6803529); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "1406633;17242355;19131326;19144319;21183079;21540332;22645316;22740652;23806337;24129315;26435271;31219806;34428180;35820727;35984892;36288343;36852467;37453647;37507081;38279469;38320300;38334757;38358439;39627609;8912629", "class_list": "", "function": "Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2., [RefSeq, PubMed]; Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins., [UniProtKB, UniProtKB]; M[6]A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis. Erratum:[Mol Neurobiol. 2024 Sep;61(9):6909. doi: 10.1007/s12035-024-04162-z. PMID: 38652353], [RefSeq, PubMed]; Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell Differentiation and Function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97312;Q3V269", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:1990825 sequence-specific mRNA binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0061752 telomeric repeat-containing RNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0051170 import into nucleus;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P49312-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U2C5-1", "uniprot_id": [ { "id": "RN149_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U2C5", "type": "external" } ], "mass": 42553.0, "length": 394, "protein_name": "E3 ubiquitin-protein ligase RNF149", "gene_name": "Rnf149", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF149 precursor", "refseq_ac": [ { "id": "NP_001028307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028307", "type": "external" } ], "gene_names_uniprotkb": "Rnf149; Greul4", "gene_names_refseq": "1600023E10Rik; Gm15832; Greul4; Rnf149", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF149; 2.3.2.27; Goliath-related E3 ubiquitin-protein ligase 4; RING finger protein 149; RING-type E3 ubiquitin transferase RNF149", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF149 precursor; E3 ubiquitin-protein ligase RNF149; RING-type E3 ubiquitin transferase RNF149; goliath-related E3 ubiquitin-protein ligase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67702)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12435366;19144319;21183079;21750661;25428506;26495903;27802388;28011936;28935714;31599954;35984892;37828378", "class_list": "", "function": "E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QAH5;Q14BF0;Q8CGR2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005770 late endosome", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3U2C5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZJ0-1", "uniprot_id": [ { "id": "RNC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5HZJ0", "type": "external" } ], "mass": 158828.0, "length": 1373, "protein_name": "Ribonuclease 3", "gene_name": "Drosha", "organism": "Mouse", "refseq_name": "ribonuclease 3", "refseq_ac": [ { "id": "NP_001123621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123621", "type": "external" } ], "gene_names_uniprotkb": "Drosha; Etohi2; Rn3; Rnasen", "gene_names_refseq": "1110013A17Rik; Drosha; Etohi2; Rn3; Rnasen", "protein_names_uniprotkb": "Ribonuclease 3; 3.1.26.3; Protein Drosha; RNase III; Ribonuclease III", "protein_names_refseq": "RNase III; ethanol induced 2; protein Drosha; ribonuclease 3; ribonuclease III, nuclear", "tax_id": 10090, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:14000)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17060477;19632182;26255770;29784949;31219806;34428180;38517158;38722021", "class_list": "", "function": "Dicer is required in a cell-autonomous fashion for the development of natural T reg cells in the thymus and for efficient induction of Foxp3 by transforming growth factor beta., [RefSeq, PubMed]; Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism., [RefSeq, PubMed]; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26255770). Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (PubMed:29784949)., [UniProtKB, UniProtKB, PubMed, PubMed]; SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046332 SMAD binding;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0050727 regulation of inflammatory response;GO:0010586 miRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5HZJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SVL6-1", "uniprot_id": [ { "id": "RPGP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SVL6", "type": "external" } ], "mass": 78254.0, "length": 712, "protein_name": "Rap1 GTPase-activating protein 2", "gene_name": "Rap1gap2", "organism": "Mouse", "refseq_name": "rap1 GTPase-activating protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001015046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015046", "type": "external" } ], "gene_names_uniprotkb": "Rap1gap2; Garnl4; Kiaa1039; Rap1ga2", "gene_names_refseq": "Garnl4; Gm1561; Rap1gap2; mKIAA1039", "protein_names_uniprotkb": "Rap1 GTPase-activating protein 2; GTPase-activating Rap/Ran-GAP domain-like protein 4; Rap1GAP2", "protein_names_refseq": "GTPase activating RANGAP domain-like 4; GTPase-activating Rap/Ran-GAP domain-like protein 4; rap1 GTPase-activating protein 2 isoform 2; rap1 GTPase-activating protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:380711); (R-MMU-392517)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16169686;21183079;21750661;22645316;22732430;31599954;34428180;36210013;40885482", "class_list": "", "function": "GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rap1gap2 overexpression limits neurite outgrowth and branching in Neuro-2a cells, and counteracts Rap1-induced augmentation of neurite outgrowth, [RefSeq, PubMed]; Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNA3;Q3V3L0;Q80TL8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0010977 negative regulation of neuron projection development;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5SVL6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDH4-1", "uniprot_id": [ { "id": "RNB3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDH4", "type": "external" } ], "mass": 54492.0, "length": 491, "protein_name": "Ran-binding protein 3-like", "gene_name": "Ranbp3l", "organism": "Mouse", "refseq_name": "ran-binding protein 3-like", "refseq_ac": [ { "id": "NP_932141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932141", "type": "external" } ], "gene_names_uniprotkb": "Ranbp3l", "gene_names_refseq": "C130037N17Rik; Ranbp3l", "protein_names_uniprotkb": "Ran-binding protein 3-like", "protein_names_refseq": "ran-binding protein 3-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:223332)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25755279;34233711", "class_list": "", "function": "Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation. Erratum:[Mol Cell Biol. 2017 Aug 11;37(17):e00287-17. doi: 10.1128/MCB.00287-17. PMID: 28801455], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1J9", "ec_number_list": [], "go_molecular_function": "GO:0046332 SMAD binding", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:1901706 mesenchymal cell differentiation involved in bone development;GO:0045668 negative regulation of osteoblast differentiation;GO:0006611 protein export from nucleus;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PDH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924T7-1", "uniprot_id": [ { "id": "RNF31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924T7", "type": "external" } ], "mass": 119314.0, "length": 1066, "protein_name": "E3 ubiquitin-protein ligase RNF31", "gene_name": "Rnf31", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF31", "refseq_ac": [ { "id": "NP_919327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919327", "type": "external" } ], "gene_names_uniprotkb": "Rnf31; Paul", "gene_names_refseq": "Flj10111; HOIP; Paul; Rnf31; mFLJ00217", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF31; 2.3.2.31; HOIL-1-interacting protein; HOIP; PAUL; Putative Ariadne-like ubiquitin ligase; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; RING-type E3 ubiquitin transferase RNF31; putative Ariadne-like ubiquitin ligase", "tax_id": 10090, "disease": "immunodeficiency 115 (Disease Ontology:DOID:0061081)", "pathway": " (mmu:268749); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11345588;14678832;21750661;23708998;28701375;29950720;34428180;38582895;38615890", "class_list": "", "function": "E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:28701375). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:28701375). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (By similarity). Binds polyubiquitin of different linkage types (By similarity)., [UniProtKB, UniProtKB, PubMed]; RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes., [RefSeq, PubMed]; Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0035631 CD40 receptor complex;GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0023035 CD40 signaling pathway;GO:0050852 T cell receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q924T7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ83-1", "uniprot_id": [ { "id": "RM55_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ83", "type": "external" } ], "mass": 15122.0, "length": 127, "protein_name": "Large ribosomal subunit protein mL55", "gene_name": "Mrpl55", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL55 isoform 1", "refseq_ac": [ { "id": "NP_001289263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289263", "type": "external" } ], "gene_names_uniprotkb": "Mrpl55", "gene_names_refseq": "2810038N09Rik; L55mt; MRP-L55; Mrpl55", "protein_names_uniprotkb": "Large ribosomal subunit protein mL55; 39S ribosomal protein L55, mitochondrial; L55mt; MRP-L55", "protein_names_refseq": "39S ribosomal protein L55, mitochondrial; large ribosomal subunit protein mL55 isoform 1; large ribosomal subunit protein mL55", "tax_id": 10090, "disease": "", "pathway": " (mmu:67212); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R030", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZ83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0X5-1", "uniprot_id": [ { "id": "RPGR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0X5", "type": "external" } ], "mass": 111801.0, "length": 1001, "protein_name": "X-linked retinitis pigmentosa GTPase regulator", "gene_name": "Rpgr", "organism": "Mouse", "refseq_name": "X-linked retinitis pigmentosa GTPase regulator isoform 1", "refseq_ac": [ { "id": "NP_001171421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171421", "type": "external" } ], "gene_names_uniprotkb": "Rpgr", "gene_names_refseq": "Rd9; Rp3h; Rpgr; mRpgr", "protein_names_uniprotkb": "X-linked retinitis pigmentosa GTPase regulator; mRpgr", "protein_names_refseq": "X-linked retinitis pigmentosa GTPase regulator isoform 1; X-linked retinitis pigmentosa GTPase regulator", "tax_id": 10090, "disease": "retinitis pigmentosa 3 (Disease Ontology:DOID:0110414); X-linked cone-rod dystrophy 1 (Disease Ontology:DOID:0111008); X-linked retinitis pigmentosa and sinorespiratory infections (Disease Ontology:DOID:0112124); X-linked atrophic macular degeneration (Disease Ontology:DOID:0112157); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:19893)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10401007;11702207;12140192;15772089;16043481;16632484;18579752;20007830;20805823;21546531;21750661;22323458;22563472;22645316;25428506;29899041;34418053;38536817;9677393;9990021", "class_list": "", "function": "Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:38536817). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (By similarity). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (PubMed:38536817). Involved in photoreceptor integrity (PubMed:22563472, PubMed:38536817). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes., [UniProtKB, PubMed]; RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ADP3;G9BBQ2;O88408;Q9CU92", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005929 cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007601 visual perception;GO:0060271 cilium assembly;GO:0010508 positive regulation of autophagy;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9R0X5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z139-1", "uniprot_id": [ { "id": "ROR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z139", "type": "external" } ], "mass": 104088.0, "length": 937, "protein_name": "Inactive tyrosine-protein kinase transmembrane receptor ROR1", "gene_name": "Ror1", "organism": "Mouse", "refseq_name": "inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001299619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299619", "type": "external" } ], "gene_names_uniprotkb": "Ror1; Ntrkr1", "gene_names_refseq": "2810404D04Rik; Ntrkr1; Ror1", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; mROR1", "protein_names_refseq": "inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor; inactive tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1; tyrosine-protein kinase transmembrane receptor ROR1", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 108 (Disease Ontology:DOID:0080263)", "pathway": " (mmu:26563); (R-MMU-5140745)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10231392;27162350;28465528;34428180;36811220;37343369;37430307", "class_list": "", "function": "Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity). In the inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-kappaB signaling pathway., [RefSeq, PubMed]; Ror1 promotes PPARalpha-mediated fatty acid metabolism in astrocytes., [RefSeq, PubMed]; This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG10", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0042813 Wnt receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043235 receptor complex;GO:0043679 axon terminus", "go_biological_process": "GO:0008283 cell population proliferation;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0007605 sensory perception of sound;GO:0048839 inner ear development;GO:0014002 astrocyte development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z139-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D687-1", "uniprot_id": [ { "id": "S6A19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D687", "type": "external" } ], "mass": 71367.0, "length": 634, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT1", "gene_name": "Slc6a19", "organism": "Mouse", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT1 isoform 1", "refseq_ac": [ { "id": "NP_083154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083154", "type": "external" } ], "gene_names_uniprotkb": "Slc6a19; B0at1; Xt3", "gene_names_refseq": "4632401C08Rik; B<0>AT1; Slc6a19", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT1; Solute carrier family 6 member 19; System B(0) neutral amino acid transporter AT1", "protein_names_refseq": "sodium-dependent neutral amino acid transporter B(0)AT1 isoform 1; sodium-dependent neutral amino acid transporter B(0)AT1; solute carrier family 6 member 19; system B(0) neutral amino acid transporter AT1", "tax_id": 10090, "disease": "Hartnup disease (Disease Ontology:DOID:1060); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:74338); (R-MMU-352230); (R-MMU-442660)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "15044460;15286787;15804236;17167413;18424768;19185582;21183079;21636576;21750661;22677001;26240152;34428180;36374036;36611813", "class_list": "", "function": "Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice., [RefSeq, PubMed]; Stage-Specific L-Proline Uptake by Amino Acid Transporter Slc6a19/B[0]AT1 Is Required for Optimal Preimplantation Embryo Development in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The mechanism of the mouse (m)B0AT1 (slc6a19) transporter was studied in detail using two electrode voltage-clamp techniques and tracer studies in the Xenopus oocyte expression system., [RefSeq, PubMed]; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15044460, PubMed:17167413, PubMed:18424768, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:15044460, PubMed:18424768, PubMed:19185582, PubMed:21636576, PubMed:26240152). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:17167413, PubMed:18424768, PubMed:19185582, PubMed:22677001)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; We isolated the human homolog of B(0)AT1, called SLC6A19, and determined its size and molecular organization. We then identified mutations in SLC6A19 in members of the original family in whom Hartnup disorder was discovered, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015293 symporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex;GO:0016020 membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D687-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XT4-1", "uniprot_id": [ { "id": "SC16B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XT4", "type": "external" } ], "mass": 115513.0, "length": 1051, "protein_name": "Protein transport protein Sec16B", "gene_name": "Sec16b", "organism": "Mouse", "refseq_name": "protein transport protein Sec16B", "refseq_ac": [ { "id": "NP_001153458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153458", "type": "external" } ], "gene_names_uniprotkb": "Sec16b; Kiaa1928; Lztr2; Rgpr", "gene_names_refseq": "Lztr2; Rgpr-p117; Rgpr; Sec16b", "protein_names_uniprotkb": "Protein transport protein Sec16B; Leucine zipper transcription regulator 2; RGPR-p117; Regucalcin gene promoter region-related protein p117; SEC16 homolog B", "protein_names_refseq": "leucine zipper transcription regulator 2; protein SEC16 homolog B; protein transport protein Sec16B; regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:89867); (R-MMU-204005)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11605020;12244571;17242355;21183079;21750661;30084848;32815086;34428180;36796587;40997131", "class_list": "", "function": "Intestinal SEC16B modulates obesity by regulating chylomicron metabolism., [RefSeq, PubMed]; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcriptional regulation of the ER stress-inducible gene Sec16B in Neuro2a cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QL61;Q69Z64;Q6PCR8", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0015031 protein transport;GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91XT4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97321-1", "uniprot_id": [ { "id": "SEPR_MOUSE", "url": "https://www.uniprot.org/uniprot/P97321", "type": "external" } ], "mass": 87945.0, "length": 761, "protein_name": "Prolyl endopeptidase FAP", "gene_name": "Fap", "organism": "Mouse", "refseq_name": "prolyl endopeptidase FAP", "refseq_ac": [ { "id": "NP_032012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032012", "type": "external" } ], "gene_names_uniprotkb": "Fap", "gene_names_refseq": "Fap; SIMP", "protein_names_uniprotkb": "Prolyl endopeptidase FAP; 3.4.14.5; 3.4.21.-; 3.4.21.26; Dipeptidyl peptidase FAP; FAPalpha; Fibroblast activation protein alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; SIMP; Seprase; Serine integral membrane protease; Surface-expressed protease", "protein_names_refseq": "FAPalpha; dipeptidyl peptidase FAP; fibroblast activation protein alpha; gelatine degradation protease FAP; integral membrane serine protease; post-proline cleaving enzyme; prolyl endopeptidase FAP; seprase; serine integral membrane protease; surface-expressed protease", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:14089)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10629066;11330865;15133496;21051638;21750661;22645316;23710635;24371721;34428180;36152535;38100414;38155020;9139873;9688278", "class_list": "", "function": "Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation., [RefSeq, PubMed]; Mechanical stiffness promotes skin fibrosis through FAPalpha-AKT signaling pathway., [RefSeq, PubMed]; This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0045177 apical part of cell", "go_biological_process": "GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:0097325 melanocyte proliferation;GO:1902362 melanocyte apoptotic process;GO:1903054 negative regulation of extracellular matrix organization;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97321-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4C3-1", "uniprot_id": [ { "id": "SFR19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4C3", "type": "external" } ], "mass": 133842.0, "length": 1256, "protein_name": "Splicing factor, arginine/serine-rich 19", "gene_name": "Scaf1", "organism": "Mouse", "refseq_name": "splicing factor, arginine/serine-rich 19 isoform 1", "refseq_ac": [ { "id": "NP_001008422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008422", "type": "external" } ], "gene_names_uniprotkb": "Scaf1; Sfrs19", "gene_names_refseq": "SR-A1; Scaf1", "protein_names_uniprotkb": "Splicing factor, arginine/serine-rich 19; SR-related and CTD-associated factor 1", "protein_names_refseq": "SR-related and CTD-associated factor 1; serine arginine-rich pre-mRNA splicing factor SR-A1; splicing factor, arginine/serine-rich 19 isoform 1; splicing factor, arginine/serine-rich 19", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:233208)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17242355;18630941;19144319;21183079;21750661;28193223;31219806;34428180;35820727;40997131", "class_list": "", "function": "May function in pre-mRNA splicing., [UniProtKB]; Overall, the data demonstrate that SR-A1/CD204 plays an important role in SPD-MAA induced inflammation in lung. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR01", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0099122 RNA polymerase II C-terminal domain binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5U4C3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZI9-1", "uniprot_id": [ { "id": "SERC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZI9", "type": "external" } ], "mass": 52623.0, "length": 472, "protein_name": "Serine incorporator 3", "gene_name": "Serinc3", "organism": "Mouse", "refseq_name": "serine incorporator 3 isoform 1", "refseq_ac": [ { "id": "NP_036162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036162", "type": "external" } ], "gene_names_uniprotkb": "Serinc3; Aigp1; Diff33; Tde1; Tms1", "gene_names_refseq": "AIGP1; DIFF33; Serinc3; TMS-1; Tde1", "protein_names_uniprotkb": "Serine incorporator 3; AIGP-1; Axotomy-induced glyco/Golgi protein 1; Axotomy-induced glycoprotein 1; Membrane protein TMS-1; Tumor differentially expressed protein 1", "protein_names_refseq": "AIGP-1; axotomy-induced glyco/Golgi protein 1; axotomy-induced glycoprotein 1; membrane protein TMS-1; serine incorporator 3 isoform 1; tumor differentially expressed 1; tumor differentially expressed protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26943); (R-MMU-977347)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10637174;12486168;16075062;16547497;17242355;17322886;19144319;20173027;25428506;26495903;27802388;28011936;30084848;30779550;31219806;34428180;7894057", "class_list": "", "function": "Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity., [UniProtKB, UniProtKB]; TDE1 inhibits apoptosis and stimulates tumorigenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7C6;Q62310;Q8BSP9;Q8CFD3;Q91VN9", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0017121 plasma membrane phospholipid scrambling;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QZI9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CUS9-1", "uniprot_id": [ { "id": "SPPL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CUS9", "type": "external" } ], "mass": 42261.0, "length": 384, "protein_name": "Signal peptide peptidase-like 3", "gene_name": "Sppl3", "organism": "Mouse", "refseq_name": "signal peptide peptidase-like 3", "refseq_ac": [ { "id": "NP_083288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083288", "type": "external" } ], "gene_names_uniprotkb": "Sppl3; Imp2; Psl4; Usmg3", "gene_names_refseq": "4833416I09Rik; Psl4; Sppl3; Usmg3", "protein_names_uniprotkb": "Signal peptide peptidase-like 3; 3.4.23.-; IMP-2; Intramembrane protease 2; Presenilin-like protein 4; SPP-like 3", "protein_names_refseq": "IMP-2; SPP-like 3 protein; intramembrane protease 2; presenilin-like protein 4; signal peptide peptidase-like 3; upregulated during skeletal muscle growth 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74585)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20562862;21750661;25354954;25384971;25827571;26851218;31219806;34428180", "class_list": "", "function": "Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971)., [UniProtKB, PubMed, PubMed, PubMed]; Our results identify SPPL3 as a cell-autonomous molecular determinant of NK cell maturation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP88;Q8R597", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0050852 T cell receptor signaling pathway;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CUS9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JB2-1", "uniprot_id": [ { "id": "STML2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JB2", "type": "external" } ], "mass": 38385.0, "length": 353, "protein_name": "Stomatin-like protein 2, mitochondrial", "gene_name": "Stoml2", "organism": "Mouse", "refseq_name": "stomatin-like protein 2, mitochondrial isoform c", "refseq_ac": [ { "id": "NP_075720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075720", "type": "external" } ], "gene_names_uniprotkb": "Stoml2; Slp2", "gene_names_refseq": "0610038F01Rik; MSLP2; SLP-2; Stoml2", "protein_names_uniprotkb": "Stomatin-like protein 2, mitochondrial; SLP-2; mslp2", "protein_names_refseq": "stomatin-like protein 2, mitochondrial isoform c; stomatin-like protein 2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:66592); (R-MMU-8949664); (R-MMU-9840373)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "16324911;16928863;19360003;21750661;22623988;22645316;22872234;23028053;23576753;23806337;25605945;26495903;26740625;27986413;28135057;28528544;28654702;29187734;31219806;34203471;34428180;36210013;36288343;37453647;37828378", "class_list": "", "function": "Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Resting or activated T cells from T cell-specific Slp-2 knockout mice showed a significant impairment in the production of several mitochondrial DNA-encoded polypeptides following T cell activation. Measurement of mitochondrial DNA stability and mitochondrial transcription revealed that this impairment was at the post-transcriptional level. Publication Status: Online-Only, [RefSeq, PubMed]; Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCG8", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0042608 T cell receptor binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0010876 lipid localization;GO:1990046 stress-induced mitochondrial fusion;GO:0051259 protein complex oligomerization;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q99JB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08599-1", "uniprot_id": [ { "id": "STXB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08599", "type": "external" } ], "mass": 67569.0, "length": 594, "protein_name": "Syntaxin-binding protein 1", "gene_name": "Stxbp1", "organism": "Mouse", "refseq_name": "syntaxin-binding protein 1 isoform a", "refseq_ac": [ { "id": "NP_001107041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107041", "type": "external" } ], "gene_names_uniprotkb": "Stxbp1", "gene_names_refseq": "MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; Rb-sec1; Stxbp1; Sxtbp1; Unc18-1; Unc18h; nsec1", "protein_names_uniprotkb": "Syntaxin-binding protein 1; Protein unc-18 homolog 1; Protein unc-18 homolog A; Unc-18A; Unc18-1", "protein_names_refseq": "UNC-18 homolog; minisatellite 10g detected by probe MMS10; protein unc-18 homolog 1; protein unc-18 homolog A; syntaxin-binding protein 1 isoform a; unc-18-1; unc-18A", "tax_id": 10090, "disease": "West syndrome (Disease Ontology:DOID:0050562); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20910); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-888590)", "pathway_count": 7, "publication_count": 22, "publication_id_list": "17242355;21183079;21445306;21750661;22039235;22517741;22645316;22765017;28821673;28935714;31599954;32848054;33300544;34428180;35822049;38316990;38349432;38360746;40684658;40885482;8824310;9705297", "class_list": "", "function": "GABAergic/Glycinergic and Glutamatergic Neurons Mediate Distinct Neurodevelopmental Phenotypes of STXBP1 Encephalopathy. Publication Status: Online-Only, [RefSeq, PubMed]; KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (PubMed:21445306, PubMed:28821673). May play a role in determining the specificity of intracellular fusion reactions (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ARS2;A2ARS3;A2ARS4;Q5WAC6;Q8VD51", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0098888 extrinsic component of presynaptic membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0061670 evoked neurotransmitter secretion;GO:0106022 positive regulation of vesicle docking;GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0002576 platelet degranulation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O08599-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88983-1", "uniprot_id": [ { "id": "STX8_MOUSE", "url": "https://www.uniprot.org/uniprot/O88983", "type": "external" } ], "mass": 26925.0, "length": 236, "protein_name": "Syntaxin-8", "gene_name": "Stx8", "organism": "Mouse", "refseq_name": "syntaxin-8 isoform 1", "refseq_ac": [ { "id": "NP_061238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061238", "type": "external" } ], "gene_names_uniprotkb": "Stx8", "gene_names_refseq": "0610007H08Rik; 1110002H11Rik; 4930571E13Rik; CARB; Stx8", "protein_names_uniprotkb": "Syntaxin-8; Syntaxin-like protein 3I35", "protein_names_refseq": "syntaxin-8 isoform 1; syntaxin-like protein 3I35", "tax_id": 10090, "disease": "", "pathway": " (mmu:55943)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18821010;19144319;25404741;28855648", "class_list": "", "function": "Syntaxin 8 and HECTd3 have similar subcellular localization., [RefSeq, PubMed]; Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability, [RefSeq, PubMed]; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0031625 ubiquitin protein ligase binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport;GO:0016192 vesicle-mediated transport;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88983-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KI8-1", "uniprot_id": [ { "id": "SRRM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q52KI8", "type": "external" } ], "mass": 106862.0, "length": 946, "protein_name": "Serine/arginine repetitive matrix protein 1", "gene_name": "Srrm1", "organism": "Mouse", "refseq_name": "serine/arginine repetitive matrix protein 1 isoform 1", "refseq_ac": [ { "id": "NP_058079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058079", "type": "external" } ], "gene_names_uniprotkb": "Srrm1; Pop101", "gene_names_refseq": "POP101; Srm160; Srrm1", "protein_names_uniprotkb": "Serine/arginine repetitive matrix protein 1; Plenty-of-prolines 101", "protein_names_refseq": "Ser/Arg-related nuclear matrix protein; plenty-of-prolines-101; serine/arginine repetitive matrix protein 1 isoform 1; serine/arginine repetitive matrix protein 1", "tax_id": 10090, "disease": "gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (mmu:51796); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-9013418); (R-MMU-9013422)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;18630941;19131326;19144319;21183079;21750661;23806337;24463520;34887587;40021952;40885482", "class_list": "", "function": "Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 71, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QNW8;O70495;Q9CVG5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix;GO:0071013 catalytic step 2 spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0000398 mRNA splicing, via spliceosome;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q52KI8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810C0-1", "uniprot_id": [ { "id": "SLIK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810C0", "type": "external" } ], "mass": 95436.0, "length": 846, "protein_name": "SLIT and NTRK-like protein 2", "gene_name": "Slitrk2", "organism": "Mouse", "refseq_name": "SLIT and NTRK-like protein 2 precursor", "refseq_ac": [ { "id": "NP_001154903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154903", "type": "external" } ], "gene_names_uniprotkb": "Slitrk2", "gene_names_refseq": "A930040J07; Slitrk2", "protein_names_uniprotkb": "SLIT and NTRK-like protein 2", "protein_names_refseq": "SLIT and NTRK-like protein 2 precursor; SLIT and NTRK-like protein 2; slit and trk like gene 2", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual developmental disorder 111 (Disease Ontology:DOID:0060929)", "pathway": " (mmu:245450); (R-MMU-388844)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;14550773;18034455;25428506;25989451;33300544;35840571", "class_list": "", "function": "It is involved in synaptogenesis (PubMed:25989451, PubMed:35840571). Promotes excitatory synapse differentiation (By similarity). Suppresses neurite outgrowth (PubMed:14550773). Involved in the negative regulation of NTRK2 (PubMed:35840571)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXL6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007409 axonogenesis;GO:0051965 positive regulation of synapse assembly;GO:0099560 synaptic membrane adhesion;GO:0050807 regulation of synapse organization;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q810C0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C079-1", "uniprot_id": [ { "id": "STRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C079", "type": "external" } ], "mass": 95585.0, "length": 837, "protein_name": "Striatin-interacting protein 1", "gene_name": "Strip1", "organism": "Mouse", "refseq_name": "striatin-interacting protein 1", "refseq_ac": [ { "id": "NP_705791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705791", "type": "external" } ], "gene_names_uniprotkb": "Strip1; Fam40a; Kiaa1761", "gene_names_refseq": "6330569M22Rik; 6530401O14Rik; Fam40a; Strip1", "protein_names_uniprotkb": "Striatin-interacting protein 1; Protein FAM40A", "protein_names_refseq": "family with sequence similarity 40, member A; protein FAM40A; striatin-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229707)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15345747;17114649;18782753;19131326;19144319;21183079;25428506;25605945;30084848;31219806;34428180;36210013", "class_list": "", "function": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80T92;Q8BZC6;Q8CIF7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0030866 cortical actin cytoskeleton organization;GO:0022604 regulation of cell morphogenesis;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C079-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K330-1", "uniprot_id": [ { "id": "SSH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K330", "type": "external" } ], "mass": 72227.0, "length": 649, "protein_name": "Protein phosphatase Slingshot homolog 3", "gene_name": "Ssh3", "organism": "Mouse", "refseq_name": "protein phosphatase Slingshot homolog 3 isoform 1", "refseq_ac": [ { "id": "NP_932781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932781", "type": "external" } ], "gene_names_uniprotkb": "Ssh3; Ssh3l", "gene_names_refseq": "SSH-3L; SSH-3; Ssh3", "protein_names_uniprotkb": "Protein phosphatase Slingshot homolog 3; 3.1.3.16; 3.1.3.48; SSH-3L; SSH-like protein 3; mSSH-3L", "protein_names_refseq": "SSH-like protein 3; protein phosphatase Slingshot homolog 3 isoform 1; protein phosphatase Slingshot homolog 3; slingshot homolog 3; slingshot-3L; slingshot-like 3", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:245857)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14531860;17242355;18442045;21183079;21750661;30084848;34428180", "class_list": "", "function": "Dephosphorylates actin-depolymerizing factor/cofilin, but is not essential for viability, fertility, or development of epithelial tissues., [RefSeq, PubMed]; Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDX0", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K330-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U186-1", "uniprot_id": [ { "id": "SYRM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U186", "type": "external" } ], "mass": 65336.0, "length": 578, "protein_name": "Probable arginine--tRNA ligase, mitochondrial", "gene_name": "Rars2", "organism": "Mouse", "refseq_name": "probable arginine--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_852071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852071", "type": "external" } ], "gene_names_uniprotkb": "Rars2; Rarsl", "gene_names_refseq": "1500002I10Rik; PRO1992; Rars2; Rarsl", "protein_names_uniprotkb": "Probable arginine--tRNA ligase, mitochondrial; 6.1.1.19; ArgRS; Arginyl-tRNA synthetase", "protein_names_refseq": "argRS; arginine--tRNA ligase; arginyl-tRNA synthetase 2, mitochondrial (putative); probable arginine--tRNA ligase, mitochondrial precursor; probable arginine--tRNA ligase, mitochondrial; probable arginyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); pontocerebellar hypoplasia type 6 (Disease Ontology:DOID:0060275)", "pathway": " (mmu:109093)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23576753;25428506;31219806;34428180;37507081", "class_list": "", "function": "Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZU7", "ec_number_list": [ { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U186-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30987-1", "uniprot_id": [ { "id": "TA2R_MOUSE", "url": "https://www.uniprot.org/uniprot/P30987", "type": "external" } ], "mass": 37098.0, "length": 341, "protein_name": "Thromboxane A2 receptor", "gene_name": "Tbxa2r", "organism": "Mouse", "refseq_name": "thromboxane A2 receptor", "refseq_ac": [ { "id": "NP_001264194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264194", "type": "external" } ], "gene_names_uniprotkb": "Tbxa2r", "gene_names_refseq": "TP; TXA2-R; Tbxa2r", "protein_names_uniprotkb": "Thromboxane A2 receptor; Prostanoid TP receptor; TXA2-R", "protein_names_refseq": "TXA2 receptor; prostanoid TP receptor; thromboxane A2 receptor; thromboxane prostanoid", "tax_id": 10090, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); kidney failure (Disease Ontology:DOID:1074); adult respiratory distress syndrome (Disease Ontology:DOID:11394); toxic shock syndrome (Disease Ontology:DOID:14115); thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:21390); (R-MMU-391908); (R-MMU-416476); (R-MMU-416482); (R-MMU-428930)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1375456;21183079", "class_list": "", "function": "Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase., [UniProtKB]; This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004961 thromboxane A2 receptor activity;GO:0004960 thromboxane receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P30987-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31266-1", "uniprot_id": [ { "id": "SUH_MOUSE", "url": "https://www.uniprot.org/uniprot/P31266", "type": "external" } ], "mass": 58537.0, "length": 526, "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "Rbpj", "organism": "Mouse", "refseq_name": "recombining binding protein suppressor of hairless isoform 2", "refseq_ac": [ { "id": "NP_001074396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074396", "type": "external" } ], "gene_names_uniprotkb": "Rbpj; Igkjrb1; Igkrsbp; Rbpsuh", "gene_names_refseq": "CBF1; Igkjrb; Igkrsbp; RBP-J kappa; RBP-Jkappa; RBP-J; RBPjk; Rbpj; Rbpsuh", "protein_names_uniprotkb": "Recombining binding protein suppressor of hairless; J kappa-recombination signal-binding protein; RBP-J kappa", "protein_names_refseq": "J-kappa recombination signal binding protein; Jkappa recombination signal binding protein; recombining binding protein suppressor of hairless isoform 2; recombining binding protein suppressor of hairless", "tax_id": 10090, "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227); Adams-Oliver syndrome 3 (Disease Ontology:DOID:0061179); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); aortic valve disease (Disease Ontology:DOID:62)", "pathway": " (mmu:19664); (R-MMU-2122947); (R-MMU-350054); (R-MMU-8941856)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10640276;11318877;11604511;17283045;1740450;18381292;1950768;21750661;23806337;25428506;2556644;25875095;26194095;28135057;29030483;29187734;40997131;7566092;9418910", "class_list": "", "function": "Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity) (PubMed:18381292). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UN8;Q8C4Z3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0048733 sebaceous gland development;GO:0072554 blood vessel lumenization;GO:0048820 hair follicle maturation;GO:0060379 cardiac muscle cell myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P31266-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLS7-1", "uniprot_id": [ { "id": "SWAHA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLS7", "type": "external" } ], "mass": 57749.0, "length": 548, "protein_name": "Ankyrin repeat domain-containing protein SOWAHA", "gene_name": "Sowaha", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein SOWAHA precursor", "refseq_ac": [ { "id": "NP_898996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898996", "type": "external" } ], "gene_names_uniprotkb": "Sowaha; Ankrd43", "gene_names_refseq": "A830006N08Rik; Ankrd43; Sowaha", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein SOWAHA; Ankyrin repeat domain-containing protein 43; Protein sosondowah homolog A", "protein_names_refseq": "ankyrin repeat domain 43; ankyrin repeat domain-containing protein 43; ankyrin repeat domain-containing protein SOWAHA precursor; ankyrin repeat domain-containing protein SOWAHA; protein sosondowah homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:237761)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149C7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BLS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TDQ1-1", "uniprot_id": [ { "id": "STT3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TDQ1", "type": "external" } ], "mass": 93246.0, "length": 823, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "gene_name": "Stt3b", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "refseq_ac": [ { "id": "NP_077184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077184", "type": "external" } ], "gene_names_uniprotkb": "Stt3b; Simp", "gene_names_refseq": "1300006C19Rik; Simp; Stt3b", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; 2.4.99.18; B6dom1 antigen; Oligosaccharyl transferase subunit STT3B; STT3-B; Source of immunodominant MHC-associated peptides", "protein_names_refseq": "B6dom1 antigen; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; oligosaccharyl transferase subunit STT3B; source of immunodominant MHC-associated peptides", "tax_id": 10090, "disease": "congenital disorder of glycosylation Iw (Disease Ontology:DOID:0080572); congenital disorder of glycosylation Ix (Disease Ontology:DOID:0080573)", "pathway": " (mmu:68292); (R-MMU-9931295)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12439619;12845499;15812391;17142744;17242355;17981332;19131326;19349973;21183079;21750661;21952136;25428507;29765039;30899004;34203471;34428180;35820727;36210013", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; N-glycosyltransferases STT3A and STT3B isoforms are sufficient and required for effective PD-L1 protein induction in the general cell population of mesenchymal-like cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TT24;Q921E3;Q99LL0;Q9D2V2", "ec_number_list": [ { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0008250 oligosaccharyltransferase complex;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006487 protein N-linked glycosylation;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q3TDQ1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVI5-1", "uniprot_id": [ { "id": "STX16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVI5", "type": "external" } ], "mass": 37080.0, "length": 326, "protein_name": "Syntaxin-16", "gene_name": "Stx16", "organism": "Mouse", "refseq_name": "syntaxin-16 isoform a", "refseq_ac": [ { "id": "NP_766263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766263", "type": "external" } ], "gene_names_uniprotkb": "Stx16", "gene_names_refseq": "4930401D03; 5430410K23Rik; 6330500A18Rik; Stx16; Syn16", "protein_names_uniprotkb": "Syntaxin-16", "protein_names_refseq": "syntaxin-16 isoform a", "tax_id": 10090, "disease": "pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222)", "pathway": " (mmu:228960); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17317779;17852734;19144319;21183079;21750661", "class_list": "", "function": "Mice genetically altered to carry the equivalent of STX16del4-6 contributing to pseudohypoparathyroidism type 1b., [RefSeq, PubMed]; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB]; Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ACM7", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0006906 vesicle fusion;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BVI5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62075-1", "uniprot_id": [ { "id": "TIM13_MOUSE", "url": "https://www.uniprot.org/uniprot/P62075", "type": "external" } ], "mass": 10458.0, "length": 95, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim13", "gene_name": "Timm13", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim13", "refseq_ac": [ { "id": "NP_038923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038923", "type": "external" } ], "gene_names_uniprotkb": "Timm13; Tim13a; Timm13a", "gene_names_refseq": "D10Ertd378e; Tim9; Timm13; Timm9", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim13", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim13; translocase of inner mitochondrial membrane 13 homolog; translocase of inner mitochondrial membrane 9 homolog", "tax_id": 10090, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (mmu:30055)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10611480;15254020;21750661;22872234;23806337;25428506;30084848;30779550;31219806;34428180;35820727", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VM6;Q9DC89;Q9UHL8;Q9WTL1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P62075-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4R4-1", "uniprot_id": [ { "id": "PITC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4R4", "type": "external" } ], "mass": 38384.0, "length": 332, "protein_name": "Cytoplasmic phosphatidylinositol transfer protein 1", "gene_name": "Pitpnc1", "organism": "Mouse", "refseq_name": "cytoplasmic phosphatidylinositol transfer protein 1 isoform 2", "refseq_ac": [ { "id": "NP_665822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665822", "type": "external" } ], "gene_names_uniprotkb": "Pitpnc1", "gene_names_refseq": "1110020B03Rik; 5830436L09Rik; C330017I21Rik; Dnr411; Pitpnc1; RDGBB1; RDGBB; mrdgBbeta; rdgB-beta", "protein_names_uniprotkb": "Cytoplasmic phosphatidylinositol transfer protein 1; M-rdgB beta; Mammalian rdgB homolog beta; MrdgBbeta; RdgBbeta; Retinal degeneration B homolog beta; mM-rdgBbeta", "protein_names_refseq": "cytoplasmic phosphatidylinositol transfer protein 1 isoform 2; cytoplasmic phosphatidylinositol transfer protein 1; diabetic nephropathy-related protein; mammalian rdgB homolog beta; retinal degeneration B homolog beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:71795)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12562526;15345747;21183079;21750661;34428180;36166181", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (By similarity). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (By similarity)., [UniProtKB, UniProtKB]; Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes. Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species., [UniProtKB, UniProtKB]; PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure., [RefSeq, PubMed]; Specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A650;A2A651;Q3TBB3;Q3U5F5;Q8K4R5", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity;GO:0035091 phosphatidylinositol binding;GO:1901611 phosphatidylglycerol binding;GO:0070300 phosphatidic acid binding;GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0015914 phospholipid transport;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4R4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42225-1", "uniprot_id": [ { "id": "STAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P42225", "type": "external" } ], "mass": 87197.0, "length": 749, "protein_name": "Signal transducer and activator of transcription 1", "gene_name": "Stat1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stat1", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal transducer and activator of transcription 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); immunodeficiency 31B (Disease Ontology:DOID:0111944); immunodeficiency 31A (Disease Ontology:DOID:0111945); immunodeficiency 31C (Disease Ontology:DOID:0111946); breast cancer (Disease Ontology:DOID:1612); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); breast carcinoma (Disease Ontology:DOID:3459); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); tuberculosis (Disease Ontology:DOID:399); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20846); (R-MMU-1059683); (R-MMU-1169408); (R-MMU-1433557); (R-MMU-186763); (R-MMU-6785807); (R-MMU-877300); (R-MMU-877312); (R-MMU-8854691); (R-MMU-8984722); (R-MMU-8985947); (R-MMU-9020956); (R-MMU-9020958); (R-MMU-909733); (R-MMU-912694); (R-MMU-9833482); (R-MMU-9860927)", "pathway_count": 17, "publication_count": 30, "publication_id_list": "11294897;11972023;12138178;16139798;17332413;19088846;21135090;21750661;21952136;22065572;23352233;24379350;25428506;26740625;27671227;28135057;29187734;29941542;30084848;31219806;31599954;34428180;35820727;36210013;37327784;37453647;38621137;39627609;7545930;9344858", "class_list": "", "function": "Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:11294897, PubMed:11972023, PubMed:19088846, PubMed:22065572, PubMed:9344858). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2 (By similarity). The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (By similarity). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:22065572). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:11972023). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (By similarity). Becomes activated in response to KITLG/SCF and KIT signaling (By similarity). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-748 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (By similarity). Phosphorylation at Thr-748 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (By similarity). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (PubMed:37327784)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0032727 positive regulation of interferon-alpha production;GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072162 metanephric mesenchymal cell differentiation;GO:0046725 negative regulation by virus of viral protein levels in host cell", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P42225-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C796-1", "uniprot_id": [ { "id": "RCOR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C796", "type": "external" } ], "mass": 57908.0, "length": 523, "protein_name": "REST corepressor 2", "gene_name": "Rcor2", "organism": "Mouse", "refseq_name": "REST corepressor 2", "refseq_ac": [ { "id": "NP_001307483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307483", "type": "external" } ], "gene_names_uniprotkb": "Rcor2", "gene_names_refseq": "1A13; CoREST; Rcor1; Rcor2; Rcor", "protein_names_uniprotkb": "REST corepressor 2; M-CoREST", "protein_names_refseq": "RE1-silencing transcription factor (REST) co-repressor 1; REST co-repressor 2; REST corepressor 2; co-repressor of Rest", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:104383)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11578870;21183079;21750661;24129315", "class_list": "", "function": "May act as a component of a corepressor complex that represses transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JMK4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C796-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4L3-1", "uniprot_id": [ { "id": "SVIL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4L3", "type": "external" } ], "mass": 243162.0, "length": 2170, "protein_name": "Supervillin", "gene_name": "Svil", "organism": "Mouse", "refseq_name": "supervillin isoform b", "refseq_ac": [ { "id": "NP_001334378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334378", "type": "external" } ], "gene_names_uniprotkb": "Svil", "gene_names_refseq": "B430302E16Rik; Svil", "protein_names_uniprotkb": "Supervillin; Archvillin; p205/p250", "protein_names_refseq": "archvillin; p205/p250; supervillin isoform b", "tax_id": 10090, "disease": "myofibrillar myopathy 10 (Disease Ontology:DOID:0112108)", "pathway": " (mmu:225115)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12711699;17242355;19131326;19144319;21183079;21750661;24129315;30084848;30779550;31112734;31599954;34428180;34678516;37507081;37828378", "class_list": "", "function": "Archvillin is among the first costameric proteins to assemble during myogenesis and that it contributes to myogenic membrane structure and differentiation., [RefSeq, PubMed]; Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q983", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing;GO:0042692 muscle cell differentiation;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K4L3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70278-1", "uniprot_id": [ { "id": "STRA8_MOUSE", "url": "https://www.uniprot.org/uniprot/P70278", "type": "external" } ], "mass": 44555.0, "length": 393, "protein_name": "Stimulated by retinoic acid gene 8 protein", "gene_name": "Stra8", "organism": "Mouse", "refseq_name": "stimulated by retinoic acid gene 8 protein isoform 1", "refseq_ac": [ { "id": "NP_033318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033318", "type": "external" } ], "gene_names_uniprotkb": "Stra8", "gene_names_refseq": "Stra8", "protein_names_uniprotkb": "Stimulated by retinoic acid gene 8 protein", "protein_names_refseq": "stimulated by retinoic acid gene 8 protein isoform 1; stimulated by retinoic acid gene 8 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20899)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14550793;16461896;17115059;18322276;18799751;18799790;19805549;20951351;21750661;25902548;32032549;32054698;8896602", "class_list": "glycogene", "function": "Meiosis-inducer required for the transition into meiosis for both female and male germ cells (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:19805549, PubMed:32032549, PubMed:32054698). In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:32054698). During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation (PubMed:25902548). In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis (PubMed:19805549, PubMed:32032549)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q496Q5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048133 male germ-line stem cell asymmetric division;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70278-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U40-1", "uniprot_id": [ { "id": "RIMB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U40", "type": "external" } ], "mass": 118342.0, "length": 1072, "protein_name": "RIMS-binding protein 2", "gene_name": "Rimbp2", "organism": "Mouse", "refseq_name": "RIMS-binding protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001074857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074857", "type": "external" } ], "gene_names_uniprotkb": "Rimbp2; Kiaa0318; Rbp2", "gene_names_refseq": "A930033C01Rik; Rimbp2; mKIAA0318", "protein_names_uniprotkb": "RIMS-binding protein 2; RIM-BP2", "protein_names_refseq": "RIMS-binding protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231760)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17855024;21183079;21750661;22517741;22645316;32848054;34353898;35822049;38329474;40021952;40885482", "class_list": "", "function": "Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RIM-BP2 regulates Ca[2+] channel abundance and neurotransmitter release at hippocampal mossy fiber terminals. Publication Status: Online-Only, [RefSeq, PubMed]; RIM-Binding Protein 2 Organizes Ca(2+) Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse., [RefSeq, PubMed]; Rimbp2 is identified in mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EKT4;E9QPF5", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0030674 protein-macromolecule adaptor activity;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0098681 synaptic ribbon", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion;GO:0099505 regulation of presynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80U40-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3E6-1", "uniprot_id": [ { "id": "STAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3E6", "type": "external" } ], "mass": 144440.0, "length": 1258, "protein_name": "Cohesin subunit SA-1", "gene_name": "Stag1", "organism": "Mouse", "refseq_name": "cohesin subunit SA-1 isoform 1", "refseq_ac": [ { "id": "NP_033308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033308", "type": "external" } ], "gene_names_uniprotkb": "Stag1; Sa1", "gene_names_refseq": "SA-1; Scc3; Stag1", "protein_names_uniprotkb": "Cohesin subunit SA-1; SCC3 homolog 1; Stromal antigen 1", "protein_names_refseq": "SCC3 homolog 1; cohesin subunit SA-1 isoform 1; cohesin subunit SA-1; stromal antigen 1", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 47 (Disease Ontology:DOID:0080238)", "pathway": " (mmu:20842); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257); (R-MMU-3108214)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "21183079;21750661;25428506;30084848;30779550;32778134;34428180;37802073;39627609;9305759", "class_list": "", "function": "Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08982;Q6P5D1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0016604 nuclear body;GO:0016363 nuclear matrix", "go_biological_process": "GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007062 sister chromatid cohesion;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D3E6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1E0-1", "uniprot_id": [ { "id": "STX5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1E0", "type": "external" } ], "mass": 39713.0, "length": 355, "protein_name": "Syntaxin-5", "gene_name": "Stx5a; Stx5", "organism": "Mouse", "refseq_name": "syntaxin-5", "refseq_ac": [ { "id": "NP_001161271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161271", "type": "external" } ], "gene_names_uniprotkb": "Stx5a; Stx5; Stx5a", "gene_names_refseq": "0610031F24Rik; D19Ertd627e; Stx5a; Stx5", "protein_names_uniprotkb": "Syntaxin-5", "protein_names_refseq": "syntaxin-5", "tax_id": 10090, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571)", "pathway": " (mmu:56389); (R-MMU-204005); (R-MMU-5694530); (R-MMU-6807878); (R-MMU-6811438); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9013408); (R-MMU-9609523)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "21750661;21913724;22872234;25428506;28000760;29187734;30084848;30779550;31599954;34203471;34428180;35820727;37828378;9705316", "class_list": "", "function": "Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stx5 is an autophagy target that is inefficiently membrane-targeted by alternative pathways; mice without WRB have different biogenesis requirements for tail anchored proteins Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM79;Q99J28;Q9JKP2", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0031982 vesicle;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045732 positive regulation of protein catabolic process;GO:0006906 vesicle fusion;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K1E0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRJ3-1", "uniprot_id": [ { "id": "RELL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRJ3", "type": "external" } ], "mass": 32326.0, "length": 303, "protein_name": "RELT-like protein 2", "gene_name": "Rell2", "organism": "Mouse", "refseq_name": "RELT-like protein 2", "refseq_ac": [ { "id": "NP_722488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722488", "type": "external" } ], "gene_names_uniprotkb": "Rell2", "gene_names_refseq": "4631403P03Rik; Rell2; ependolin", "protein_names_uniprotkb": "RELT-like protein 2", "protein_names_refseq": "RELT-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:225392)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;32848054;34678516", "class_list": "", "function": "Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0010811 positive regulation of cell-substrate adhesion;GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BRJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0Q5-1", "uniprot_id": [ { "id": "RHG18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0Q5", "type": "external" } ], "mass": 74930.0, "length": 663, "protein_name": "Rho GTPase-activating protein 18", "gene_name": "Arhgap18", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 18", "refseq_ac": [ { "id": "NP_789807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807", "type": "external" } ], "gene_names_uniprotkb": "Arhgap18", "gene_names_refseq": "4833419J07Rik; Arhgap18", "protein_names_uniprotkb": "Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18", "protein_names_refseq": "rho GTPase-activating protein 18; rho-type GTPase-activating protein 18", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:73910); (R-MMU-8980692); (R-MMU-9013106)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21183079;21750661;21865595;25425145;28251925;28701309;32013974", "class_list": "", "function": "ARHGAP 18 was identified as a novel protective gene against thoracic aortic aneurysm formation., [RefSeq, PubMed]; In endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis., [RefSeq, PubMed]; Results describe ARHGAP18 as a novel negative regulator of sprouting by acting dualistically to limit tip cell formation and to maintain junctional integrity., [RefSeq, PubMed]; Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration (By similarity)., [UniProtKB, UniProtKB]; YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP03;Q8R196", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0001726 ruffle", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051056 regulation of small GTPase mediated signal transduction;GO:2000145 regulation of cell motility;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K0Q5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2APX8-1", "uniprot_id": [ { "id": "SCN1A_MOUSE", "url": "https://www.uniprot.org/uniprot/A2APX8", "type": "external" } ], "mass": 228800.0, "length": 2009, "protein_name": "Sodium channel protein type 1 subunit alpha", "gene_name": "Scn1a", "organism": "Mouse", "refseq_name": "sodium channel protein type 1 subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_001300926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300926", "type": "external" } ], "gene_names_uniprotkb": "Scn1a", "gene_names_refseq": "B230332M13; Nav1.1; Scn1a", "protein_names_uniprotkb": "Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1", "protein_names_refseq": "sodium channel protein brain I subunit alpha; sodium channel protein type 1 subunit alpha isoform 1; sodium channel protein type 1 subunit alpha; sodium channel protein type I subunit alpha; voltage-gated sodium channel subunit alpha Nav1.1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy 6B (Disease Ontology:DOID:0070379); Dravet syndrome (Disease Ontology:DOID:0080422); familial hemiplegic migraine 3 (Disease Ontology:DOID:0111183); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (mmu:20265)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15746173;16921370;17928448;20100831;21183079;21750661;22908258;22914087;26694226;27281198;30899004;33300544", "class_list": "", "function": "Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:16921370, PubMed:17928448, PubMed:27281198). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (PubMed:16921370, PubMed:22914087). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (PubMed:27281198)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 8, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2APX6;A2APX7;Q68V28", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0001508 action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "A2APX8-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88811-1", "uniprot_id": [ { "id": "STAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88811", "type": "external" } ], "mass": 57455.0, "length": 523, "protein_name": "Signal transducing adapter molecule 2", "gene_name": "Stam2", "organism": "Mouse", "refseq_name": "signal transducing adapter molecule 2 isoform a", "refseq_ac": [ { "id": "NP_062641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062641", "type": "external" } ], "gene_names_uniprotkb": "Stam2; Hbp", "gene_names_refseq": "1200004O12Rik; 5730456G07Rik; Hbp; Stam2", "protein_names_uniprotkb": "Signal transducing adapter molecule 2; Hrs-binding protein; STAM-2", "protein_names_refseq": "Hrs binding protein; STAM-2; hrs-binding protein; signal transducing adapter molecule 2 isoform a; signal transducing adapter molecule 2", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322)", "pathway": " (mmu:56324); (R-MMU-182971); (R-MMU-5689880); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9013420); (R-MMU-917729)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10651905;10982817;12446783;12551915;12972556;13129930;16159959;21750661;22143071;25428506;25605945;30084848;31599954;32782141;34428180;34678516", "class_list": "", "function": "Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity)., [UniProtKB, PubMed]; STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway., [RefSeq, PubMed]; Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development., [RefSeq, PubMed]; These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AU00;Q8C8Y4", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0007165 signal transduction;GO:0015031 protein transport;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O88811-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46978-1", "uniprot_id": [ { "id": "STT3A_MOUSE", "url": "https://www.uniprot.org/uniprot/P46978", "type": "external" } ], "mass": 80598.0, "length": 705, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "gene_name": "Stt3a", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "refseq_ac": [ { "id": "NP_032434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032434", "type": "external" } ], "gene_names_uniprotkb": "Stt3a; Itm1", "gene_names_refseq": "B5; Itm1; Stt3a", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; 2.4.99.18; B5; Integral membrane protein 1; Oligosaccharyl transferase subunit STT3A; STT3-A", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; integral membrane protein 1; oligosaccharyl transferase subunit STT3A", "tax_id": 10090, "disease": "congenital disorder of glycosylation Iw (Disease Ontology:DOID:0080572)", "pathway": " (mmu:16430); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;12887896;15781470;18299400;19349973;20173027;21750661;21952136;25428506;25428507;25605945;27802388;28512128;28528544;29765039;30084848;30779550;30899004;31219806;31599954;34428180;35820727;36210013;37453647;37658376;37828378;40885482;8838310", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. STT3A-containing OST-A complex is also required to prevent hyperglycosylation of some target proteins by preventing glycosylation of facultative sites before folding of target proteins is completed., [UniProtKB, UniProtKB]; FAT4 overexpression promotes antitumor immunity by regulating the beta-catenin/STT3/PD-L1 axis in cervical cancer. Publication Status: Online-Only, [RefSeq, PubMed]; N-glycosyltransferases STT3A and STT3B isoforms are sufficient and required for effective PD-L1 protein induction in the general cell population of mesenchymal-like cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that most of the STT3 TMDs are well inserted into the ER membrane on their own or in the presence of the natural flanking residues., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0046872 metal ion binding;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006487 protein N-linked glycosylation;GO:0180058 protein co-translational transfer of dolichol-linked oligosaccharide;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P46978-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08639-1", "uniprot_id": [ { "id": "TFDP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08639", "type": "external" } ], "mass": 45231.0, "length": 410, "protein_name": "Transcription factor Dp-1", "gene_name": "Tfdp1", "organism": "Mouse", "refseq_name": "transcription factor Dp-1 isoform 1", "refseq_ac": [ { "id": "NP_001278694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278694", "type": "external" } ], "gene_names_uniprotkb": "Tfdp1", "gene_names_refseq": "Dp1; Drtf1; Tfdp1", "protein_names_uniprotkb": "Transcription factor Dp-1; DRTF1-polypeptide 1; E2F dimerization partner 1", "protein_names_refseq": "DRTF1-polypeptide 1; E2F dimerization partner 1; cell cycle regulatory transcription factor DP1; transcription factor Dp-1 isoform 1", "tax_id": 10090, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182)", "pathway": " (mmu:21781); (R-MMU-1538133); (R-MMU-2173796); (R-MMU-69231); (R-MMU-8953750)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;20176812;21183079;21750661;25940086;31219806;35212626;37715794;39043964;8405995;8413592;8446173;9149906;9376316", "class_list": "", "function": "Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812)., [UniProtKB, UniProtKB, PubMed]; In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis., [RefSeq, PubMed]; KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0070345 negative regulation of fat cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q08639-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61233-1", "uniprot_id": [ { "id": "PLSL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61233", "type": "external" } ], "mass": 70149.0, "length": 627, "protein_name": "Plastin-2", "gene_name": "Lcp1", "organism": "Mouse", "refseq_name": "plastin-2", "refseq_ac": [ { "id": "NP_001234913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001234913", "type": "external" } ], "gene_names_uniprotkb": "Lcp1; Pls2", "gene_names_refseq": "D14Ertd310e; LCP-1; Lcp1; Pls2; pp65", "protein_names_uniprotkb": "Plastin-2; 65 kDa macrophage protein; L-plastin; LCP-1; Lymphocyte cytosolic protein 1; pp65", "protein_names_refseq": "65 kDa macrophage protein; L-fimbrin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); plastin 2, L; plastin-2", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:18826)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11465105;14756805;16075062;18250455;19144319;2026884;21183079;21750661;21913724;25428506;26495903;26740625;27802388;28011936;28935714;29125738;29187734;29255075;32069316;32152506;34428180;35294888;35984892;37453647;39627609;7897227;8060349;9893048", "class_list": "", "function": "Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69., [UniProtKB, UniProtKB]; L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE24;Q8R1X3;Q9CV77", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0022617 extracellular matrix disassembly;GO:0051017 actin filament bundle assembly;GO:0009611 response to wounding;GO:0031100 animal organ regeneration", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q61233-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1N1-1", "uniprot_id": [ { "id": "PLPL8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1N1", "type": "external" } ], "mass": 87381.0, "length": 776, "protein_name": "Calcium-independent phospholipase A2-gamma", "gene_name": "Pnpla8", "organism": "Mouse", "refseq_name": "calcium-independent phospholipase A2-gamma", "refseq_ac": [ { "id": "NP_080440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080440", "type": "external" } ], "gene_names_uniprotkb": "Pnpla8; Ipla22; Ipla2g", "gene_names_refseq": "1200006O19Rik; Ipla2(gamma); Pnpla8", "protein_names_uniprotkb": "Calcium-independent phospholipase A2-gamma; 3.1.1.-; 3.1.1.5; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-gamma", "protein_names_refseq": "calcium-independent phospholipase A2-gamma; iPLA2-gamma; intracellular membrane-associated calcium-independent phospholipase A2 gamma; patatin-like phospholipase domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:67452); (R-MMU-1482788); (R-MMU-1482839)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10833412;15024020;15471944;17213206;17923475;19840936;21750661;23806337;25428506;28442572;31219806;32879212;34428180;36210013;36719796;39480824", "class_list": "", "function": "Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:17923475, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Also has a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine (By similarity). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:17923475, PubMed:28442572)., [UniProtKB, UniProtKB, PubMed, PubMed]; Gene Deletion of Calcium-Independent Phospholipase A2gamma (iPLA2gamma) Suppresses Adipogenic Differentiation of Mouse Embryonic Fibroblasts., [RefSeq, PubMed]; Genetic deletion of calcium-independent phospholipase A2gamma protects mice from diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups., [RefSeq, PubMed]; IPLA(2)beta and iPLA(2)gamma are required for the adipogenic program that drives resting 3T3-L1 cells into adipocytes after hormone stimulation, [RefSeq, PubMed]; IPLA(2)gamma is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition, [RefSeq, PubMed]; IPLA2 signaling plays an important role in glucose-stimulated insulin secretion under physiological conditions, [RefSeq, PubMed]; The obligatory role of iPLA(2)gamma in neuronal mitochondrial lipid metabolism and membrane structure demonstrating that iPLA(2)gamma loss of function results in a mitochondrial neurodegenerative disorder, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH33;Q8VEC0;Q9DC20", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0004620 phospholipase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0035556 intracellular signal transduction;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K1N1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70576-1", "uniprot_id": [ { "id": "STAG3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70576", "type": "external" } ], "mass": 141167.0, "length": 1240, "protein_name": "Cohesin subunit SA-3", "gene_name": "Stag3", "organism": "Mouse", "refseq_name": "cohesin subunit SA-3", "refseq_ac": [ { "id": "NP_058660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058660", "type": "external" } ], "gene_names_uniprotkb": "Stag3", "gene_names_refseq": "SA-2; Stag3", "protein_names_uniprotkb": "Cohesin subunit SA-3; SCC3 homolog 3; Stromal antigen 3; Stromalin-3", "protein_names_refseq": "SCC3 homolog 3; cohesin subunit SA-3; stromal antigen 3; stromalin-3", "tax_id": 10090, "disease": "primary ovarian insufficiency 8 (Disease Ontology:DOID:0080865); spermatogenic failure 61 (Disease Ontology:DOID:0112350)", "pathway": " (mmu:50878)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10698974;11483963;21183079;21750661;22346761;24413433;24597867;30853435", "class_list": "", "function": "Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I., [UniProtKB, PubMed, PubMed]; STAG3 deficiency has a major effect on DNA double-strand breaks number even in the absence of PRDM9, showing that its role is not restricted to canonical PRDM9-activated hotspots. Erratum:[Curr Biol. 2021 Mar 22;31(6):1351. doi: 10.1016/j.cub.2021.03.002. PMID: 33756132], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSV0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007066 female meiosis sister chromatid cohesion;GO:0007129 homologous chromosome pairing at meiosis;GO:0034502 protein localization to chromosome;GO:0007062 sister chromatid cohesion;GO:0007065 male meiosis sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70576-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM90-1", "uniprot_id": [ { "id": "STAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM90", "type": "external" } ], "mass": 34628.0, "length": 297, "protein_name": "Signal-transducing adaptor protein 1", "gene_name": "Stap1", "organism": "Mouse", "refseq_name": "signal-transducing adaptor protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001297568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297568", "type": "external" } ], "gene_names_uniprotkb": "Stap1", "gene_names_refseq": "Brdg1; STAP-1; Stap1", "protein_names_uniprotkb": "Signal-transducing adaptor protein 1; STAP-1; Stem cell adaptor protein 1", "protein_names_refseq": "BCR downstream signaling 1; signal-transducing adaptor protein 1 isoform 2; signal-transducing adaptor protein 1; stem cell adaptor protein STAP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56792)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10679268;17947660;21750661;33175848;33228548;34428180;37462801;38315039", "class_list": "", "function": "Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells. Erratum:[PLoS One. 2021 Apr 15;16(4):e0250536. doi: 10.1371/journal.pone.0250536. PMID: 33857256] Publication Status: Online-Only, [RefSeq, PubMed]; May function as an adapter molecule downstream of KIT in the proliferation or differentiation of hematopoietic stem cells., [UniProtKB, PubMed]; Mice lacking global Stap1 expression do not manifest hypercholesterolemia. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation., [RefSeq, PubMed]; Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6C6;Q3TRM1;Q6PES6", "ec_number_list": [], "go_molecular_function": "GO:0005157 macrophage colony-stimulating factor receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0030296 protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:1900028 negative regulation of ruffle assembly;GO:1904140 negative regulation of microglial cell migration;GO:1904151 positive regulation of microglial cell mediated cytotoxicity;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JM90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQM0-1", "uniprot_id": [ { "id": "RFFL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQM0", "type": "external" } ], "mass": 42249.0, "length": 377, "protein_name": "E3 ubiquitin-protein ligase rififylin", "gene_name": "Rffl", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase rififylin isoform 4", "refseq_ac": [ { "id": "NP_001158042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158042", "type": "external" } ], "gene_names_uniprotkb": "Rffl", "gene_names_refseq": "1700051E09Rik; 4930516L10Rik; Carp2; Rffl", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rififylin; 2.3.2.27; Fring; RING finger and FYVE-like domain-containing protein 1; RING-type E3 ubiquitin transferase rififylin", "protein_names_refseq": "E3 ubiquitin-protein ligase rififylin isoform 4; E3 ubiquitin-protein ligase rififylin; RING finger and FYVE-like domain-containing protein 1; RING-type E3 ubiquitin transferase rififylin; fring", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:67338); (R-MMU-6804757)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15229288;17242355;19138581;21183079;21750661;22609986;24114843", "class_list": "", "function": "CARP2 [Rififylin] deficiency does not alter induction of NF-kappaB by TNFalpha., [RefSeq, PubMed]; Data show that the the amino-terminal domain of rififylin is critical for its recruitment to recycling endocytic membranes and for the inhibition of recycling., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling., [UniProtKB, PubMed, PubMed]; EGF, which signals through CRAF, and an activated BRAF mutant also activate PKC and stimulate cell migration through up-regulating RFFL expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVC2;Q5SVC4;Q9D543;Q9D9B1", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0006886 intracellular protein transport;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6ZQM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H6A9-1", "uniprot_id": [ { "id": "RBG1L_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H6A9", "type": "external" } ], "mass": 92404.0, "length": 815, "protein_name": "Rab GTPase-activating protein 1-like", "gene_name": "Rabgap1l", "organism": "Mouse", "refseq_name": "rab GTPase-activating protein 1-like isoform b", "refseq_ac": [ { "id": "NP_001033710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710", "type": "external" } ], "gene_names_uniprotkb": "Rabgap1l; Hhl; Kiaa0471", "gene_names_refseq": "5830411O09Rik; 8430421H08Rik; 9630005B12Rik; HHL; Hh1; Rabgap1l; mKIAA0471", "protein_names_uniprotkb": "Rab GTPase-activating protein 1-like", "protein_names_refseq": "rab GTPase-activating protein 1-like isoform b; rab GTPase-activating protein 1-like; rab6 GTPase activating protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:29809)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10585558;17242355;21183079;21750661;25428506;27718357;30084848;31219806;34428180", "class_list": "", "function": "GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357)., [UniProtKB, UniProtKB, PubMed]; We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH20;Q80TZ4;Q8BZD2;Q8BZP0;Q8CFI6;Q9QY69", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0032880 regulation of protein localization;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A6H6A9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35134-1", "uniprot_id": [ { "id": "RPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35134", "type": "external" } ], "mass": 194110.0, "length": 1717, "protein_name": "DNA-directed RNA polymerase I subunit RPA1", "gene_name": "Polr1a", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase I subunit RPA1", "refseq_ac": [ { "id": "NP_033114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033114", "type": "external" } ], "gene_names_uniprotkb": "Polr1a; Rpa1; Rpo1-4", "gene_names_refseq": "194kDa; 2900087K15Rik; 3010014K16Rik; Polr1a; RPA194; Rpo1-4; mRPA1", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA1; 2.7.7.6; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A1; RPA194", "protein_names_refseq": "DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I subunit RPA1; RNA polymerase 1-4 (194 kDa subunit); RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A1", "tax_id": 10090, "disease": "acrofacial dysostosis Cincinnati type (Disease Ontology:DOID:0060353); hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786)", "pathway": " (mmu:20019); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10589839;12446911;16514417;20173027;21750661;25428506;30084848;30272023;30746471;30779550;31219806;34428180;35820727;37075751;9236775", "class_list": "", "function": "Analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy [RPA43], [RefSeq, PubMed]; Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (By similarity). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:10589839)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSA9", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:1904750 negative regulation of protein localization to nucleolus;GO:0009303 rRNA transcription;GO:0006362 transcription elongation by RNA polymerase I;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O35134-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH75-1", "uniprot_id": [ { "id": "RNF41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH75", "type": "external" } ], "mass": 35891.0, "length": 317, "protein_name": "E3 ubiquitin-protein ligase NRDP1", "gene_name": "Rnf41", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase NRDP1", "refseq_ac": [ { "id": "NP_001157709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157709", "type": "external" } ], "gene_names_uniprotkb": "Rnf41; Flrf; Nrdp1", "gene_names_refseq": "2210404G21Rik; 4930511A05Rik; 4933415P08Rik; D10Ertd722e; FLRF; Nrdp1; Rnf41", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NRDP1; 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1", "protein_names_refseq": "E3 ubiquitin-protein ligase NRDP1; RING-type E3 ubiquitin transferase NRDP1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:67588); (R-MMU-1358803); (R-MMU-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "17384230;18495327;19483718;21750661;24949970;34428180;37759433;38431041;38583443;38654108", "class_list": "", "function": "Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Also promotes activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970)., [UniProtKB, PubMed, PubMed, PubMed]; Correlation between neuregulin receptor degradation protein-1 and Crohn's disease., [RefSeq, PubMed]; Nrdp1-mediated Macrophage Phenotypic Regulation Promotes Functional Recovery in Mice with Mild Neurological Impairment after Intracerebral Hemorrhage., [RefSeq, PubMed]; Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGJ2;Q8BMC9;Q8VEA2;Q9CRK6;Q9D568", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005135 interleukin-3 receptor binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1901525 negative regulation of mitophagy;GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BH75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P99029-1", "uniprot_id": [ { "id": "PRDX5_MOUSE", "url": "https://www.uniprot.org/uniprot/P99029", "type": "external" } ], "mass": 21897.0, "length": 210, "protein_name": "Peroxiredoxin-5, mitochondrial", "gene_name": "Prdx5", "organism": "Mouse", "refseq_name": "peroxiredoxin-5, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_036151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036151", "type": "external" } ], "gene_names_uniprotkb": "Prdx5; Prdx6", "gene_names_refseq": "AOEB166; AOPP; PLP; Pmp20; Prdx5; Prdx6; PrxV", "protein_names_uniprotkb": "Peroxiredoxin-5, mitochondrial; 1.11.1.24; AOEB166; Antioxidant enzyme B166; Liver tissue 2D-page spot 2D-0014IV; PLP; Peroxiredoxin V; Peroxisomal antioxidant enzyme; Prx-V; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5", "protein_names_refseq": "antioxidant enzyme B166; liver tissue 2D-page spot 2D-0014IV; peroxiredoxin 6; peroxiredoxin V; peroxiredoxin-5, mitochondrial isoform 1 precursor; peroxiredoxin-5, mitochondrial; peroxisomal antioxidant enzyme; peroxisomal membrane protein 20; thioredoxin peroxidase PMP20; thioredoxin reductase; thioredoxin-dependent peroxiredoxin 5", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459)", "pathway": " (mmu:54683); (R-MMU-3299685); (R-MMU-5628897)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10514471;10521424;10679306;10753630;21183079;21750661;23576753;23806337;31740833;32152506;34428180;36288343;37024271;37453647;37507081;38115765;39927985", "class_list": "", "function": "Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer., [RefSeq, PubMed]; Mitochondrial peroxiredoxin 5 overexpression suppresses insulin-induced adipogenesis by downregulating the phosphorylation of p38., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QX45;Q9QZ75", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding;GO:0072541 peroxynitrite reductase activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0060785 regulation of apoptosis involved in tissue homeostasis;GO:2001057 reactive nitrogen species metabolic process;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0032967 positive regulation of collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P99029-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EF0-1", "uniprot_id": [ { "id": "RAB3I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68EF0", "type": "external" } ], "mass": 47133.0, "length": 428, "protein_name": "Rab-3A-interacting protein", "gene_name": "Rab3ip", "organism": "Mouse", "refseq_name": "rab-3A-interacting protein isoform 2", "refseq_ac": [ { "id": "NP_001003950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003950", "type": "external" } ], "gene_names_uniprotkb": "Rab3ip; Rabin8", "gene_names_refseq": "B230311A06; Gtpat12; Rab3ip; Rabin3", "protein_names_uniprotkb": "Rab-3A-interacting protein; Rab3A-interacting protein; Rabin-3; SSX2-interacting protein", "protein_names_refseq": "SSX2-interacting protein; gene trap PAT 12; rab-3A-interacting protein isoform 2; rab-3A-interacting protein; rab3A-interacting protein; rabin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:216363); (R-MMU-5620912); (R-MMU-5620916); (R-MMU-5620922); (R-MMU-8876198)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;28135057;32848054;35820727", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051020 GTPase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0060271 cilium assembly;GO:0051490 negative regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q68EF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VN19-1", "uniprot_id": [ { "id": "RBP10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VN19", "type": "external" } ], "mass": 67188.0, "length": 620, "protein_name": "Ran-binding protein 10", "gene_name": "Ranbp10", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ranbp10; Kiaa1464", "gene_names_refseq": "", "protein_names_uniprotkb": "Ran-binding protein 10; RanBP10", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:74334); (R-MMU-8851805)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14684163;15345747;17242355;18347012;19801445;21183079;21750661;25428506;27622290;31219806;34428180", "class_list": "", "function": "May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (PubMed:18347012). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (PubMed:19801445)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZJ1;Q8C328;Q8R1E6", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0000151 ubiquitin ligase complex;GO:0034657 GID complex", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6VN19-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35929-1", "uniprot_id": [ { "id": "REM1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35929", "type": "external" } ], "mass": 32909.0, "length": 297, "protein_name": "GTP-binding protein REM 1", "gene_name": "Rem1", "organism": "Mouse", "refseq_name": "GTP-binding protein REM 1", "refseq_ac": [ { "id": "NP_033073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033073", "type": "external" } ], "gene_names_uniprotkb": "Rem1; Rem", "gene_names_refseq": "E030011C07Rik; Ras; Rem1; Rem", "protein_names_uniprotkb": "GTP-binding protein REM 1; Rad and Gem-like GTP-binding protein 1", "protein_names_refseq": "GTP-binding protein REM 1; RAS-like GTP binding protein Rem; rad and Gem-like GTP-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19700)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10441394;14623965;16648185;21183079;21750661;22854599;24476902;24806927;27115600;34428180;9268335", "class_list": "", "function": "Amino-termini of Rad and Rem as the structural elements dictating the specific modes of inhibition of CaV1.1, [RefSeq, PubMed]; Both Rem and Rad bind directly to Ca2+ channel beta-subunits (CaV beta) in vivo, [RefSeq, PubMed]; Loss of an REM1 protein increased L-type calcium current density in vivo in cardiac myocytes., [RefSeq, PubMed]; Promotes endothelial cell sprouting and actin cytoskeletal reorganization (By similarity). May be involved in angiogenesis. May function in Ca(2+) signaling., [UniProtKB]; Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes., [RefSeq, PubMed]; These results reveal that similar molecular determinants on Rem are repurposed to initiate 2 independent mechanisms of CaV1.2 inhibition., [RefSeq, PubMed]; We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031674 I band;GO:0030315 T-tubule", "go_biological_process": "GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling;GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35929-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D620-1", "uniprot_id": [ { "id": "RFIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D620", "type": "external" } ], "mass": 70684.0, "length": 645, "protein_name": "Rab11 family-interacting protein 1", "gene_name": "Rab11fip1", "organism": "Mouse", "refseq_name": "rab11 family-interacting protein 1 isoform 2", "refseq_ac": [ { "id": "NP_083699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083699", "type": "external" } ], "gene_names_uniprotkb": "Rab11fip1; Rcp", "gene_names_refseq": "2010200K21Rik; 4833414G05Rik; Rab11fip1; Rcp", "protein_names_uniprotkb": "Rab11 family-interacting protein 1; Rab-coupling protein; Rab11-FIP1", "protein_names_refseq": "Rab coupling protein; rab-coupling protein; rab11 family-interacting protein 1 isoform 2; rab11 family-interacting protein 1; rab11-FIP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75767)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19131326;19144319;21183079;21750661;30084848;30779550;32640214;35819177", "class_list": "", "function": "A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion., [RefSeq, PubMed]; Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05A58;Q3UBC2;Q8BN24", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0070164 negative regulation of adiponectin secretion;GO:0015031 protein transport;GO:0045055 regulated exocytosis;GO:0010817 regulation of hormone levels", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D620-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TS73-1", "uniprot_id": [ { "id": "RFLA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TS73", "type": "external" } ], "mass": 22606.0, "length": 204, "protein_name": "Refilin-A", "gene_name": "Rflna", "organism": "Mouse", "refseq_name": "refilin-A", "refseq_ac": [ { "id": "NP_082719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082719", "type": "external" } ], "gene_names_uniprotkb": "Rflna; Cfm2; Fam101a", "gene_names_refseq": "3110032G18Rik; Fam101a; Rflna; cfm2; cfm", "protein_names_uniprotkb": "Refilin-A; RefilinA; Regulator of filamin protein A", "protein_names_refseq": "family with sequence similarity 101, member A; filamin-interacting protein FAM101A; protein FAM101A; refilin-A; refilinA; regulator of filamin protein A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73121)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15661651;21709252;24129315;24436304;30084848;34428180", "class_list": "", "function": "Cfm does not have any known functional domains, but is conserved in human, chick, Xenopus and zebrafish. A cfm null mutant was live-born without any apparent defects., [RefSeq, PubMed]; Filamin a,b-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeleton., [RefSeq, PubMed]; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXQ6", "ec_number_list": [], "go_molecular_function": "GO:0031005 filamin binding", "go_cellular_component": "GO:0032432 actin filament bundle", "go_biological_process": "GO:1900158 negative regulation of bone mineralization involved in bone maturation;GO:0061572 actin filament bundle organization;GO:0048705 skeletal system morphogenesis;GO:0061182 negative regulation of chondrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TS73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5S7-1", "uniprot_id": [ { "id": "REC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5S7", "type": "external" } ], "mass": 67425.0, "length": 591, "protein_name": "Meiotic recombination protein REC8 homolog", "gene_name": "Rec8", "organism": "Mouse", "refseq_name": "meiotic recombination protein REC8 homolog isoform 1", "refseq_ac": [ { "id": "NP_064386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064386", "type": "external" } ], "gene_names_uniprotkb": "Rec8; Mei8; Rec8L1", "gene_names_refseq": "Rec8L1; Rec8; mrec", "protein_names_uniprotkb": "Meiotic recombination protein REC8 homolog; Cohesin Rec8p", "protein_names_refseq": "REC8-like 1; cohesin Rec8p; meiotic cohesion Rec8; meiotic recombination protein REC8 homolog isoform 1; meiotic recombination protein REC8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:56739)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10207075;12034751;12130806;12759374;15515002;15935783;16855401;21183079;22346761;27932493;35712867;36571142", "class_list": "", "function": "Alpha-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells., [RefSeq, PubMed]; Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice., [RefSeq, PubMed]; MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage., [RefSeq, PubMed]; Rec8 protein, in association with SMC3 and SMC1beta but not SMC1alpha, is involved in meiosis-specific chromosome behavior; homologous chromosome separation is triggered by selective loss of Rec8 from chromosome arms in meiosis I., [RefSeq, PubMed]; Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIN9;Q9JK52", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0006302 double-strand break repair;GO:0001556 oocyte maturation;GO:0072520 seminiferous tubule development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C5S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0C1-1", "uniprot_id": [ { "id": "RN115_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0C1", "type": "external" } ], "mass": 33859.0, "length": 305, "protein_name": "E3 ubiquitin-protein ligase RNF115", "gene_name": "Rnf115", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF115", "refseq_ac": [ { "id": "NP_080682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080682", "type": "external" } ], "gene_names_uniprotkb": "Rnf115; Zfp364; Znf364", "gene_names_refseq": "2610028E05Rik; Rnf115; Zfp364", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF115; 2.3.2.27; RING finger protein 115; RING-type E3 ubiquitin transferase RNF115; Rab7-interacting RING finger protein; Rabring 7; Zinc finger protein 364", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF115; RING-type E3 ubiquitin transferase RNF115; Rab7-interacting RING finger protein; Rabring7; rabring 7; zinc finger protein 364", "tax_id": 10090, "disease": "", "pathway": " (mmu:67845); (R-MMU-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12972561;17462600;21750661;23418353;33139700;36281581;38129372", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes the 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of various substrates and thereby plays a role in a number of signaling pathways including autophagy, innate immunity, cell proliferation and cell death (PubMed:36281581). Plays a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4 through their polyubiquitination. Participates together with BST2 in antiviral immunity by facilitating the internalization of HIV-1 virions into intracellular vesicles leading to their lysosomal degradation. Also possesses an antiviral activity independently of BST2 by promoting retroviral GAG proteins ubiquitination, redistribution to endo-lysosomal compartments and, ultimately, lysosomal degradation. Catalyzes distinct types of ubiquitination on MAVS and STING1 at different phases of viral infection to promote innate antiviral response. Mediates the 'Lys-48'-linked ubiquitination of MAVS leading to its proteasomal degradation and ubiquitinates STING1 via 'Lys-63'-linked polyubiquitination, critical for its oligomerization and the subsequent recruitment of TBK1 (PubMed:33139700). Plays a positive role in the autophagosome-lysosome fusion by interacting with STX17 and enhancing its stability without affecting 'Lys-48'- or 'Lys-63'-linked polyubiquitination levels, which in turn promotes autophagosome maturation. Negatively regulates TLR-induced expression of proinflammatory cytokines by catalyzing 'Lys-11'-linked ubiquitination of RAB1A and RAB13 to inhibit post-ER trafficking of TLRs to the Golgi by RAB1A and subsequently from the Golgi apparatus to the cell surface by RAB13., [UniProtKB, UniProtKB, PubMed, PubMed]; RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Publication Status: Online-Only, [RefSeq, PubMed]; RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response. Publication Status: Online-Only, [RefSeq, PubMed]; Rabring7 plays crucial roles as a Rab7 target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis (rabring7), [RefSeq, PubMed]; The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5A1;Q9D885", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D0C1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D708-1", "uniprot_id": [ { "id": "S10AG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D708", "type": "external" } ], "mass": 14324.0, "length": 124, "protein_name": "Protein S100-A16", "gene_name": "S100a16", "organism": "Mouse", "refseq_name": "protein S100-A16", "refseq_ac": [ { "id": "NP_080692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080692", "type": "external" } ], "gene_names_uniprotkb": "S100a16", "gene_names_refseq": "2300002L21Rik; DT1P1A7; S100F; S100a16", "protein_names_uniprotkb": "Protein S100-A16; Protein S100F; S100 calcium binding protein A16", "protein_names_refseq": "protein S100-A16", "tax_id": 10090, "disease": "", "pathway": " (mmu:67860)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14684152;17030513;21266506;21750661;23526364;28011936;34428180;37151881", "class_list": "", "function": "Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro). Overexpression in 3T3-L1 preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (PubMed:21266506, PubMed:23526364)., [UniProtKB, PubMed, PubMed, PubMed]; In situ hybridization analysis and immunohistochemistry revealed a widespread distribution in the mouse brain. Furthermore, S100A16 expression was found to be astrocyte-specific, [RefSeq, PubMed]; S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development. Publication Status: Online-Only, [RefSeq, PubMed]; This study showed that S100A16 protein is a novel adipogenesis-promoting factor and that increased expression of S100A16 in 3T3-L1 adipocytes can have a negative impact on insulin sensitivity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVE3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14B02-1", "uniprot_id": [ { "id": "RN133_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14B02", "type": "external" } ], "mass": 43102.0, "length": 382, "protein_name": "E3 ubiquitin-protein ligase RNF133", "gene_name": "Rnf133", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF133 isoform 2", "refseq_ac": [ { "id": "NP_937894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937894", "type": "external" } ], "gene_names_uniprotkb": "Rnf133; Greul2", "gene_names_refseq": "Greul2; Rnf133", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF133; 2.3.2.27; Goliath-related E3 ubiquitin-protein ligase 2; RING finger protein 133; RING-type E3 ubiquitin transferase RNF133", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF133 isoform 2; E3 ubiquitin-protein ligase RNF133; RING-type E3 ubiquitin transferase RNF133; goliath-related E3 ubiquitin-protein ligase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:386611)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12435366;18574499;35831855;37828378", "class_list": "", "function": "Has E3 ubiquitin-protein ligase activity (PubMed:18574499). Plays a role in male fecundity through the interaction with the E2 ubituitin-protein ligase UBE2J1 (PubMed:35831855)., [UniProtKB, PubMed, PubMed]; Study identified a potential testis-specific gene named Rnf133., [RefSeq, PubMed]; The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1F1;Q8CGR0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q14B02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URY0-1", "uniprot_id": [ { "id": "RTL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URY0", "type": "external" } ], "mass": 34266.0, "length": 304, "protein_name": "Retrotransposon Gag-like protein 4", "gene_name": "Rtl4", "organism": "Mouse", "refseq_name": "retrotransposon Gag-like protein 4", "refseq_ac": [ { "id": "NP_001028967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028967", "type": "external" } ], "gene_names_uniprotkb": "Rtl4; Mar4; Mart4; Sirh11; Zcchc16", "gene_names_refseq": "C230031A03Rik; Mar4; Rtl4; Zcchc16", "protein_names_uniprotkb": "Retrotransposon Gag-like protein 4; Mammalian retrotransposon-derived protein 4; Sushi-XF2b protein; Sushi-ichi-related retrotransposon homolog 11; Zinc finger CCHC domain-containing protein 16", "protein_names_refseq": "gag-like protein; mammalian retrotransposon-derived protein 4; retrotransposon Gag-like protein 4; sushi-XF2b protein; sushi-ichi-related retrotransposon homolog 11; zinc finger CCHC domain-containing protein 16; zinc finger, CCHC domain containing 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:619287)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15716091;16093683;16155747;26402067", "class_list": "", "function": "Involved in cognitive function in the brain, possibly via the noradrenergic system., [UniProtKB, PubMed]; Sirh11/Zcchc16 is the first SIRH gene to be involved in brain function, instead of just the placenta, as seen in the case of Peg10, Peg11/Rtl1 and Sirh7/Ldoc1 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AMQ0;B2RSQ2;Q3UVU7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0050890 cognition;GO:0042415 norepinephrine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3URY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYH6-1", "uniprot_id": [ { "id": "RRS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYH6", "type": "external" } ], "mass": 41552.0, "length": 365, "protein_name": "Ribosome biogenesis regulatory protein homolog", "gene_name": "Rrs1", "organism": "Mouse", "refseq_name": "ribosome biogenesis regulatory protein homolog", "refseq_ac": [ { "id": "NP_067486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067486", "type": "external" } ], "gene_names_uniprotkb": "Rrs1; MNCb-2643; Rrr", "gene_names_refseq": "5730466A07Rik; D1Ertd701e; Rrr; Rrs1", "protein_names_uniprotkb": "Ribosome biogenesis regulatory protein homolog", "protein_names_refseq": "RRS1 ribosome biogenesis regulator homolog; regulator for ribosome resistance homolog; ribosome biogenesis regulatory protein homolog", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:59014)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19433866;24463520", "class_list": "", "function": "Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus., [UniProtKB, UniProtKB]; Mammalian Rrs1 is localized both in the nucleolus as well as in the endoplasmic reticulum (ER) of neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQW6;Q9CS27;Q9D2B2;Q9D6M6;Q9JJC1", "ec_number_list": [], "go_molecular_function": "GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CYH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BR65-1", "uniprot_id": [ { "id": "SDS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BR65", "type": "external" } ], "mass": 38107.0, "length": 328, "protein_name": "Sin3 histone deacetylase corepressor complex component SDS3", "gene_name": "Suds3", "organism": "Mouse", "refseq_name": "sin3 histone deacetylase corepressor complex component SDS3 isoform b", "refseq_ac": [ { "id": "NP_001116138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116138", "type": "external" } ], "gene_names_uniprotkb": "Suds3; Sds3", "gene_names_refseq": "2400003N08Rik; 2410008L21Rik; Suds3; mSds3", "protein_names_uniprotkb": "Sin3 histone deacetylase corepressor complex component SDS3; Suppressor of defective silencing 3 protein homolog", "protein_names_refseq": "sin3 histone deacetylase corepressor complex component SDS3 isoform b; sin3 histone deacetylase corepressor complex component SDS3; suppressor of defective silencing 3 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71954); (R-MMU-3214815); (R-MMU-5689880)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11909966;14522945;15489224;17242355;19144319;21183079;21750661;22398430;23123966;34428180;39008037", "class_list": "", "function": "MSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells., [RefSeq, PubMed]; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)., [UniProtKB, UniProtKB, PubMed]; SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway., [RefSeq, PubMed]; These data define a role for Suds3 in activation of FGF4/ERK signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UC92;Q6P6K1;Q7TNT0;Q8BRR7;Q8K5B4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0070822 Sin3-type complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BR65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU38-1", "uniprot_id": [ { "id": "SCNNB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU38", "type": "external" } ], "mass": 72197.0, "length": 638, "protein_name": "Epithelial sodium channel subunit beta", "gene_name": "Scnn1b", "organism": "Mouse", "refseq_name": "epithelial sodium channel subunit beta", "refseq_ac": [ { "id": "NP_001258952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258952", "type": "external" } ], "gene_names_uniprotkb": "Scnn1b", "gene_names_refseq": "Scnn1b", "protein_names_uniprotkb": "Epithelial sodium channel subunit beta; Amiloride-sensitive sodium channel subunit beta; Beta-ENaC; Beta-NaCH; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB", "protein_names_refseq": "ENaC beta; SCNEB; amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel subunit beta; nonvoltage-gated sodium channel 1 subunit beta", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); bronchiectasis 1 (Disease Ontology:DOID:0080526); nephrotic syndrome (Disease Ontology:DOID:1184); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); cystic fibrosis (Disease Ontology:DOID:1485); ischemia (Disease Ontology:DOID:326); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:20277); (R-MMU-2672351); (R-MMU-9730628)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10409305;11244092;12424229;15123669;21183079;21750661;30084848;30779550;39016176;9990092", "class_list": "", "function": "Bone marrow monocytes and macrophages from mice lacking betaENaC and ASIC2 have a reduced chemotactic migration response and polarization., [RefSeq, PubMed]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:10409305). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:9990092). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:9990092). This subunit is not essential for ENaC function in airway surface liquid homeostasis and proper mucus clearance (PubMed:9990092)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0002283 neutrophil activation involved in immune response;GO:0008217 regulation of blood pressure;GO:0032094 response to food;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WU38-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A098-1", "uniprot_id": [ { "id": "SBP2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A098", "type": "external" } ], "mass": 119641.0, "length": 1086, "protein_name": "Selenocysteine insertion sequence-binding protein 2-like", "gene_name": "Secisbp2l", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Secisbp2l; Kiaa0256", "gene_names_refseq": "", "protein_names_uniprotkb": "Selenocysteine insertion sequence-binding protein 2-like; SECIS-binding protein 2-like", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "17242355;21750661;34428180", "class_list": "", "function": "Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0043021 ribonucleoprotein complex binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0001514 selenocysteine incorporation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6A098-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UVW3-1", "uniprot_id": [ { "id": "S38A6_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UVW3", "type": "external" } ], "mass": 50253.0, "length": 457, "protein_name": "Solute carrier family 38 member 6", "gene_name": "Slc38a6", "organism": "Mouse", "refseq_name": "solute carrier family 38 member 6", "refseq_ac": [ { "id": "NP_001032806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032806", "type": "external" } ], "gene_names_uniprotkb": "Slc38a6; Snat6", "gene_names_refseq": "EG625098; Slc38a6", "protein_names_uniprotkb": "Solute carrier family 38 member 6; Amino acid transporter SLC38A6", "protein_names_refseq": "Na(+)-coupled neutral amino acid transporter 6; amino acid transporter SLC38A6; probable sodium-coupled neutral amino acid transporter 6; solute carrier family 38 member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:625098)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;24752331;33503881;34428180;36707853", "class_list": "", "function": "Amino acid transporter with an apparent selectivity for L-glutamine and L-glutamate. May facilitate glutamine uptake in excitatory neurons. The transport mechanism remains to be elucidated., [UniProtKB, PubMed]; SLC38A6 expression in macrophages exacerbates pulmonary inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXN5", "ec_number_list": [], "go_molecular_function": "GO:0015186 L-glutamine transmembrane transporter activity;GO:0005313 L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006868 glutamine transport;GO:0003333 amino acid transmembrane transport;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G3UVW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35609-1", "uniprot_id": [ { "id": "SCAM3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35609", "type": "external" } ], "mass": 38458.0, "length": 349, "protein_name": "Secretory carrier-associated membrane protein 3", "gene_name": "Scamp3", "organism": "Mouse", "refseq_name": "secretory carrier-associated membrane protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001296838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296838", "type": "external" } ], "gene_names_uniprotkb": "Scamp3", "gene_names_refseq": "Sc3; Scamp3", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 3; Secretory carrier membrane protein 3", "protein_names_refseq": "secretory carrier-associated membrane protein 3 isoform 1; secretory carrier-associated membrane protein 3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:24045)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11050114;18250455;19144319;20485683;21183079;21750661;23418353;25428506;26495903;26740625;28011936;30779550;31599954;32848054;34428180;9378760", "class_list": "", "function": "Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUV6;Q99M48;Q9ERM9", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032526 response to retinoic acid;GO:0006887 exocytosis;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O35609-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62342-1", "uniprot_id": [ { "id": "SELT_MOUSE", "url": "https://www.uniprot.org/uniprot/P62342", "type": "external" } ], "mass": 22292.0, "length": 195, "protein_name": "Thioredoxin reductase-like selenoprotein T", "gene_name": "Selenot", "organism": "Mouse", "refseq_name": "thioredoxin reductase-like selenoprotein T precursor", "refseq_ac": [ { "id": "NP_001035486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035486", "type": "external" } ], "gene_names_uniprotkb": "Selenot; Selt", "gene_names_refseq": "2810407C02Rik; 5730408P04Rik; Selenot; Selt", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T; 1.8.1.9; SelT", "protein_names_refseq": "thioredoxin reductase-like enzyme; thioredoxin reductase-like selenoprotein T precursor; thioredoxin reductase-like selenoprotein T", "tax_id": 10090, "disease": "", "pathway": " (mmu:69227)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19935881;23913443;26497036;26866473;31219806;31599954;34428180;35066506", "class_list": "", "function": "Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT., [RefSeq, PubMed]; Data suggest SelT is expressed in pancreatic beta- and delta-cells; inactivation of SelT in beta-cells leads to glucose intolerance via impaired glucose homeostasis and PACAP (pituitary adenylate cyclase-activating polypeptide) insulinotropic effect., [RefSeq, PubMed]; SELENOT Deficiency in the Mouse Brain Impacts Catecholaminergic Neuron Density: An Immunohistochemical, in situ Hybridization and 3D Light-Sheet Imaging Study., [RefSeq, PubMed]; SelT exerts a neuroprotective role which is essential during brain development, and that its loss impairs mice behavior., [RefSeq, PubMed]; Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (PubMed:23913443)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD., [RefSeq, PubMed]; This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTC6;O95904;Q8CHV4;Q9CZ45;Q9NZJ3", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0031016 pancreas development;GO:0009749 response to glucose;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62342-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03517-1", "uniprot_id": [ { "id": "SCG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03517", "type": "external" } ], "mass": 70644.0, "length": 617, "protein_name": "Secretogranin-2", "gene_name": "Scg2", "organism": "Mouse", "refseq_name": "secretogranin-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033155", "type": "external" } ], "gene_names_uniprotkb": "Scg2; Chgc; Scg-2", "gene_names_refseq": "Chgc; Scg2; SgII", "protein_names_uniprotkb": "Secretogranin-2; Chromogranin-C; Secretogranin II; SgII", "protein_names_refseq": "chromogranin-C; secretogranin-2 isoform 1 precursor; secretogranin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20254); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1468571;21183079;25333865;31219806;32152506;34203471;39225388;9654353", "class_list": "", "function": "Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules., [UniProtKB, UniProtKB]; SCG2 mediates blood-brain barrier dysfunction and schizophrenia-like behaviors after traumatic brain injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y79;Q9CW80", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0031045 dense core granule", "go_biological_process": "GO:0001525 angiogenesis;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0001938 positive regulation of endothelial cell proliferation;GO:2000352 negative regulation of endothelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03517-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z180-1", "uniprot_id": [ { "id": "SETBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z180", "type": "external" } ], "mass": 173077.0, "length": 1582, "protein_name": "SET-binding protein", "gene_name": "Setbp1", "organism": "Mouse", "refseq_name": "SET-binding protein", "refseq_ac": [ { "id": "NP_444329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444329", "type": "external" } ], "gene_names_uniprotkb": "Setbp1; Kiaa0437", "gene_names_refseq": "C130092E12; Seb; Setbp1; mKIAA0437", "protein_names_uniprotkb": "SET-binding protein; SEB", "protein_names_refseq": "SET-binding protein", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 29 (Disease Ontology:DOID:0070059); Schinzel Giedion syndrome (Disease Ontology:DOID:0070509)", "pathway": " (mmu:240427)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11231286;22566606;23806337;25428506;30084848;34418053;35820727;37464069", "class_list": "", "function": "SETBP1 is dispensable for normal and malignant hematopoiesis., [RefSeq, PubMed]; Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q66JL8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z180-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUI0-1", "uniprot_id": [ { "id": "RHOA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUI0", "type": "external" } ], "mass": 21782.0, "length": 193, "protein_name": "Transforming protein RhoA", "gene_name": "Rhoa", "organism": "Mouse", "refseq_name": "transforming protein RhoA precursor", "refseq_ac": [ { "id": "NP_001300890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300890", "type": "external" } ], "gene_names_uniprotkb": "Rhoa; Arha2; Arha", "gene_names_refseq": "Arha1; Arha2; Arha; Rhoa", "protein_names_uniprotkb": "Transforming protein RhoA; 3.6.5.2", "protein_names_refseq": "aplysia ras-related homolog A; ras homolog gene family, member A; transforming protein RhoA precursor; transforming protein RhoA", "tax_id": 10090, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11848); (R-MMU-114604); (R-MMU-193634); (R-MMU-198203); (R-MMU-209563); (R-MMU-2173791); (R-MMU-392451); (R-MMU-3928662); (R-MMU-3928663); (R-MMU-4086400); (R-MMU-416482); (R-MMU-416550); (R-MMU-416572); (R-MMU-4420097); (R-MMU-5625740); (R-MMU-5625900); (R-MMU-5625970); (R-MMU-5627117); (R-MMU-5663220); (R-MMU-5666185); (R-MMU-5689896); (R-MMU-6785631); (R-MMU-6798695); (R-MMU-8849471); (R-MMU-8980692); (R-MMU-8985586); (R-MMU-9013106)", "pathway_count": 27, "publication_count": 30, "publication_id_list": "11058585;11777936;12654918;14697203;19737918;20974804;21543326;21750661;21852563;22628549;23275618;24352656;24872548;24938713;26495903;27342776;28284839;29088697;30972066;31399635;33300544;34428180;37453647;37507081;37828378;8662891;9214622;9535835;9598304;9635436", "class_list": "", "function": "Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:14697203). Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:11777936, PubMed:20974804). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Involved in the reorientation of endothelial cells and their actin stress fibers in response to cellular mechantransduction-mediated activation by ARHGEF40 (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (By similarity). May be an activator of PLCE1 (PubMed:9635436). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88336", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0043297 apical junction assembly;GO:1990869 cellular response to chemokine;GO:0043931 ossification involved in bone maturation;GO:0021861 forebrain radial glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9QUI0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60611-1", "uniprot_id": [ { "id": "SATB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60611", "type": "external" } ], "mass": 85880.0, "length": 764, "protein_name": "DNA-binding protein SATB1", "gene_name": "Satb1", "organism": "Mouse", "refseq_name": "DNA-binding protein SATB1 isoform 1", "refseq_ac": [ { "id": "NP_001157102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157102", "type": "external" } ], "gene_names_uniprotkb": "Satb1", "gene_names_refseq": "2610306G12Rik; Satb1", "protein_names_uniprotkb": "DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1", "protein_names_refseq": "DNA-binding protein SATB1 isoform 1; DNA-binding protein Satb1", "tax_id": 10090, "disease": "SATB2-associated syndrome (Disease Ontology:DOID:0060428); Sjogren's syndrome (Disease Ontology:DOID:12894)", "pathway": " (mmu:20230); (R-MMU-111465); (R-MMU-4551638)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10373541;10716941;11463840;12692553;15814699;15851481;17057718;18722016;19103759;19386260;20173027;21183079;21750661;23762260;26305964;26495903;30084848;35820727;8114718;9271405", "class_list": "", "function": "Essential role for SATB1 late in the development and maturation of CD8SP T cells, [RefSeq, PubMed]; In thymocyte nuclei, SATB1 has a cage-like 'network' distribution circumscribing heterochromatin and selectively tethers specialized DNA sequences onto its network, [RefSeq, PubMed]; Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (PubMed:26305964)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SATB1-mediated transcriptional repression is regulated by nuclear matrix binding, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XB1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016363 nuclear matrix;GO:0016605 PML body", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0060004 reflex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q60611-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYZ8-1", "uniprot_id": [ { "id": "SSBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYZ8", "type": "external" } ], "mass": 37846.0, "length": 361, "protein_name": "Single-stranded DNA-binding protein 2", "gene_name": "Ssbp2", "organism": "Mouse", "refseq_name": "single-stranded DNA-binding protein 2 isoform 1", "refseq_ac": [ { "id": "NP_077148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077148", "type": "external" } ], "gene_names_uniprotkb": "Ssbp2; Ssdp2", "gene_names_refseq": "1500004K09Rik; 2310079I02Rik; 9330163K02Rik; A830008M03Rik; Hspc116; SSDP2; Ssbp2", "protein_names_uniprotkb": "Single-stranded DNA-binding protein 2; Sequence-specific single-stranded-DNA-binding protein 2", "protein_names_refseq": "sequence-specific single-stranded-DNA-binding protein 2; single-stranded DNA-binding protein 2 isoform 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:66970)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;23806337;24129315;25428506;30084848;32848054;34893534", "class_list": "", "function": "GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B1B188;Q99LX9", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CYZ8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35288-1", "uniprot_id": [ { "id": "RAB23_MOUSE", "url": "https://www.uniprot.org/uniprot/P35288", "type": "external" } ], "mass": 26678.0, "length": 237, "protein_name": "Ras-related protein Rab-23", "gene_name": "Rab23", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rab23; Opb", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-23; 3.6.5.2; Protein open brain; Rab-15", "protein_names_refseq": "", "tax_id": 10090, "disease": "Carpenter syndrome 1 (Disease Ontology:DOID:0061098)", "pathway": " (R-MMU-8873719)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11071781;11449277;14617350;1555775;16034420;16364285;16463280;18218620;21750661;31219806;40825043;40885482;7720556;8125302", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). In conjunction with IFT57 and KIF17, it drives the localization of specific G protein-coupled receptors, such as the dopamime receptor DRD1, to primary cilia (By similarity). Has a critical role in the formation and elongation of neuronal primary cilia, thereby impacting the activation of sonic hedgehog (Shh) signaling (PubMed:40825043). Additionally, it is involved in the down-regulation of Shh signaling by cooperating with SUFU to prevent the nuclear import of GLI1 transcription factor, thus suppressing its transcriptional activity (PubMed:11449277, PubMed:16364285). Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0021513 spinal cord dorsal/ventral patterning;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35288-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BN58-1", "uniprot_id": [ { "id": "RHG28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BN58", "type": "external" } ], "mass": 81795.0, "length": 729, "protein_name": "Rho GTPase-activating protein 28", "gene_name": "Arhgap28", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 28 isoform 2", "refseq_ac": [ { "id": "NP_001334339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334339", "type": "external" } ], "gene_names_uniprotkb": "Arhgap28; Kiaa1314", "gene_names_refseq": "Arhgap28; E130310N06", "protein_names_uniprotkb": "Rho GTPase-activating protein 28; Rho-type GTPase-activating protein 28", "protein_names_refseq": "rho GTPase-activating protein 28 isoform 2; rho GTPase-activating protein 28; rho-type GTPase-activating protein 28", "tax_id": 10090, "disease": "allergic disease (Disease Ontology:DOID:1205); meningioma (Disease Ontology:DOID:3565)", "pathway": " (mmu:268970); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17525332;21183079;21750661;25211221;30059200;31219806", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB]; Together, these data suggest that the regulation of Rho by RhoGAPs, including Arhgap28, during the assembly and development of mechanically strong tissues is complex and may involve multiple RhoGAPs. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSH7;Q3UR11;Q3UZQ7;Q69ZM1;Q6NY11", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030054 cell junction", "go_biological_process": "GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0051497 negative regulation of stress fiber assembly;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BN58-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55103-1", "uniprot_id": [ { "id": "PRAX_MOUSE", "url": "https://www.uniprot.org/uniprot/O55103", "type": "external" } ], "mass": 147688.0, "length": 1391, "protein_name": "Periaxin", "gene_name": "Prx", "organism": "Mouse", "refseq_name": "periaxin isoform S", "refseq_ac": [ { "id": "NP_062285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062285", "type": "external" } ], "gene_names_uniprotkb": "Prx", "gene_names_refseq": "L-Periaxin; Prx", "protein_names_uniprotkb": "Periaxin", "protein_names_refseq": "periaxin isoform S", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); Charcot-Marie-Tooth disease type 4F (Disease Ontology:DOID:0110193)", "pathway": " (mmu:19153)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10671475;10839370;11430802;15356632;18205176;21183079;21745462;21750661;22764250;23022068;26538089;31219806;32130108;9488714", "class_list": "", "function": "Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells (PubMed:11430802, PubMed:21745462, PubMed:22764250). Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli (PubMed:10839370). Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions (PubMed:15356632). Required for normal remyelination after nerve injury (PubMed:10839370). Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses (PubMed:15356632, PubMed:23022068). Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions (PubMed:15356632, PubMed:23022068). Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves (PubMed:22764250, PubMed:23022068). Recruits DRP2 to the Schwann cell plasma membrane (PubMed:11430802, PubMed:22764250, PubMed:23022068). Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology (PubMed:21745462)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Taken together, these observations reveal that AnkB is required for Prx membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55104", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0019233 sensory perception of pain;GO:0019226 transmission of nerve impulse;GO:0032287 peripheral nervous system myelin maintenance;GO:0043484 regulation of RNA splicing;GO:0032290 peripheral nervous system myelin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O55103-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWB6-1", "uniprot_id": [ { "id": "STEA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWB6", "type": "external" } ], "mass": 55760.0, "length": 489, "protein_name": "Metalloreductase STEAP2", "gene_name": "Steap2", "organism": "Mouse", "refseq_name": "metalloreductase STEAP2 isoform 1", "refseq_ac": [ { "id": "NP_001096626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096626", "type": "external" } ], "gene_names_uniprotkb": "Steap2", "gene_names_refseq": "4921538B17Rik; IPCA-1; IPCA1; PCANAP1; STAMP1; STMP; Steap2", "protein_names_uniprotkb": "Metalloreductase STEAP2; 1.16.1.-; Six-transmembrane epithelial antigen of prostate 2", "protein_names_refseq": "metalloreductase STEAP2 isoform 1; metalloreductase STEAP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74051)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16609065;19196137;21183079;21750661;23874564;29940176;31599954;36583372;37828378;38872435", "class_list": "", "function": "Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16609065). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065)., [UniProtKB, PubMed, UniProtKB]; Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-kappaB pathway., [RefSeq, PubMed]; STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice., [RefSeq, PubMed]; Stamp1 and Stamp2 play critical roles in adipogenesis, but through different mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner, [RefSeq, PubMed]; Unveiling the role of copper metabolism and STEAP2 in idiopathic pulmonary fibrosis molecular landscape., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS12", "ec_number_list": [ { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008823 cupric reductase (NADH) activity;GO:0052851 ferric-chelate reductase (NADPH) activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0045055 regulated exocytosis;GO:0009725 response to hormone;GO:0015677 copper ion import;GO:0098706 iron ion import across cell outer membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BWB6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83917-1", "uniprot_id": [ { "id": "CBX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P83917", "type": "external" } ], "mass": 21418.0, "length": 185, "protein_name": "Chromobox protein homolog 1", "gene_name": "Cbx1", "organism": "Mouse", "refseq_name": "chromobox protein homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_031648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031648", "type": "external" } ], "gene_names_uniprotkb": "Cbx1; Cbx", "gene_names_refseq": "Cbx-rs2; Cbx1; Cbx; E430007M08Rik; HP1B; Hp1beta; M31; MOD1", "protein_names_uniprotkb": "Chromobox protein homolog 1; HP1 beta; Heterochromatin protein 1 homolog beta; Heterochromatin protein p25; M31; Modifier 1 protein", "protein_names_refseq": "chromobox homolog 1; chromobox protein homolog 1 isoform 1; chromobox protein homolog 1; heterochromatin protein 1 homolog beta; heterochromatin protein p25; modifier 1 protein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:12412); (R-MMU-9940465)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10202156;10562550;10747027;11242053;11571267;11882902;14765118;15145825;16537907;1708124;34428180;37087635;8978696;9171360", "class_list": "", "function": "Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11242053). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (By similarity). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (PubMed:11571267)., [UniProtKB, PubMed, UniProtKB, PubMed]; Dominant-negative variants in CBX1 cause a neurodevelopmental disorder., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23197", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:1990226 histone methyltransferase binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0016604 nuclear body;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0010467 gene expression;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P83917-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TME0-1", "uniprot_id": [ { "id": "PLPR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TME0", "type": "external" } ], "mass": 83290.0, "length": 766, "protein_name": "Phospholipid phosphatase-related protein type 4", "gene_name": "Plppr4", "organism": "Mouse", "refseq_name": "phospholipid phosphatase-related protein type 4", "refseq_ac": [ { "id": "NP_808332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808332", "type": "external" } ], "gene_names_uniprotkb": "Plppr4; D3Bwg0562e; Kiaa0455; Lppr4; Php1; Prg1", "gene_names_refseq": "A330086D10; D3Bwg0562e; Lppr4; PRG-1; Plppr4; mKIAA0455", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 4; Brain-specific phosphatidic acid phosphatase-like protein 1; Inactive 2-lysophosphatidate phosphatase PLPPR4; Lipid phosphate phosphatase-related protein type 4; PRG-1; Plasticity-related gene 1 protein", "protein_names_refseq": "2-lysophosphatidate phosphatase PLPPR4; brain-specific phosphatidic acid phosphatase-like protein 1; inactive 2-lysophosphatidate phosphatase PLPPR4; lipid phosphate phosphatase-related protein type 4; phospholipid phosphatase-related protein type 4; plasticity related gene 1; plasticity-related gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:229791); (R-MMU-419408)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12730698;19766573;21183079;21750661;22645316;26671989;30084848;34678516;36977636", "class_list": "", "function": "Mutations in plasticity-related-gene-1 (PRG-1) protein contribute to hippocampal seizure susceptibility and modify epileptic phenotype., [RefSeq, PubMed]; PRG-1 as an important player in the modulatory control of hippocampal excitability dependent on presynaptic LPA(2) receptor signaling. Erratum:[Cell. 2011 Sep 16;146(6):1043], [RefSeq, PubMed]; Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways (PubMed:19766573). Binds lysophosphatidic acid (LPA) and mediates its internalization into cells (PubMed:26671989). Could act as receptor or a transporter of this lipid at the post-synaptic membrane (PubMed:19766573, PubMed:26671989). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ15;Q6ZQA8;Q8BV73;Q8BXK2;Q8R3R6", "ec_number_list": [], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007409 axonogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7TME0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27612-1", "uniprot_id": [ { "id": "PLAP_MOUSE", "url": "https://www.uniprot.org/uniprot/P27612", "type": "external" } ], "mass": 87221.0, "length": 794, "protein_name": "Phospholipase A-2-activating protein", "gene_name": "Plaa", "organism": "Mouse", "refseq_name": "phospholipase A-2-activating protein isoform 1", "refseq_ac": [ { "id": "NP_766283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766283", "type": "external" } ], "gene_names_uniprotkb": "Plaa; Plap", "gene_names_refseq": "2410007N06; D4Ertd618e; PLA2P; PLAP; Plaa; Ufd3", "protein_names_uniprotkb": "Phospholipase A-2-activating protein; PLA2P; PLAP", "protein_names_refseq": "phospholipase A-2-activating protein isoform 1; phospholipase A-2-activating protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18786)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "2052621;21750661;22846677;23806337;28007986;28413018;31219806;32782141;34428180;39927985;7665086", "class_list": "", "function": "MiR-203 may regulate expression of the novel nociceptive mediator PLAA after incision., [RefSeq, PubMed]; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (PubMed:28413018). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:28007986)., [UniProtKB, PubMed, PubMed, UniProtKB]; We demonstrate that PLAA is essential for neural function, through dual roles of (1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and (2) directing sorting of synaptic vesicle (SV) components during recycling, essential for synaptic function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4QPD6;Q8C6C4", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0016005 phospholipase A2 activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0010992 ubiquitin recycling;GO:0006954 inflammatory response;GO:0007399 nervous system development;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P27612-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63934-1", "uniprot_id": [ { "id": "PO4F2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63934", "type": "external" } ], "mass": 43173.0, "length": 411, "protein_name": "POU domain, class 4, transcription factor 2", "gene_name": "Pou4f2", "organism": "Mouse", "refseq_name": "POU domain, class 4, transcription factor 2", "refseq_ac": [ { "id": "NP_620394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620394", "type": "external" } ], "gene_names_uniprotkb": "Pou4f2; Brn-3.2; Brn3b", "gene_names_refseq": "Brn-3.2; Brn-3b; Brn3b; Pou4f-rs1; Pou4f2; mBrn3-3R", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 2; Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3.2; Brn-3B", "protein_names_refseq": "POU domain, class 4, transcription factor 2; POU domain, class 4, transcription factor, related sequence 1; brain-3B; brain-specific homeobox/POU domain protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18997); (R-MMU-6804759)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10357904;10414983;10526314;11163266;14726699;15733064;16152597;17145718;17668438;18368538;21875655;22326227;23805044;24643061;25775587;7691107;7797498;7852360;7904822;7935408;8065921;8162704;8290353;8537352;8632990;8637595;8662774;8972215;8995448;9111308;9261145;9448000;9694219", "class_list": "", "function": "Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:10357904, PubMed:10414983, PubMed:11163266, PubMed:17668438, PubMed:25775587, PubMed:7904822, PubMed:8972215, PubMed:8995448). Functions either as activator or repressor by modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:10526314, PubMed:15733064, PubMed:17145718, PubMed:18368538, PubMed:7797498, PubMed:7852360, PubMed:7904822, PubMed:7935408, PubMed:8065921, PubMed:8662774, PubMed:9694219). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes (PubMed:10414983, PubMed:16152597, PubMed:17668438, PubMed:24643061, PubMed:7904822, PubMed:8290353, PubMed:9111308). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:10357904, PubMed:25775587, PubMed:8632990). Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding (PubMed:10357904, PubMed:11163266, PubMed:24643061, PubMed:25775587, PubMed:8972215, PubMed:8995448, PubMed:9261145). Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification (PubMed:21875655). In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis (PubMed:17145718). Negatively regulates BAX promoter activity in the absence of TP53 (PubMed:17145718). Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter (PubMed:9448000). Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif (PubMed:7852360, PubMed:7935408, PubMed:8065921, PubMed:8537352, PubMed:8662774). Involved in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63954", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex;GO:0000791 euchromatin", "go_biological_process": "GO:1902870 negative regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q63934-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XI4-1", "uniprot_id": [ { "id": "PI42B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XI4", "type": "external" } ], "mass": 47319.0, "length": 416, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "gene_name": "Pip4k2b", "organism": "Mouse", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "refseq_ac": [ { "id": "NP_473392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473392", "type": "external" } ], "gene_names_uniprotkb": "Pip4k2b; Pip5k2b", "gene_names_refseq": "PI5P4Kbeta; Pip4k2b; Pip5k2b; c11", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 2.7.1.149; Diphosphoinositide kinase 2-beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PtdIns(5)P-4-kinase isoform 2-beta", "protein_names_refseq": "1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; diphosphoinositide kinase 2-beta; phosphatidylinositol 5-phosphate 4-kinase type-2 beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:108083); (R-MMU-1660499); (R-MMU-6811555); (R-MMU-6811558); (R-MMU-8847453)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12438746;21183079;25153642;25728392;28528544;29727621;32449185", "class_list": "", "function": "Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain., [RefSeq, PubMed]; Located within a 185-kb contig surrounding a transgene on chromosome 11, [RefSeq, PubMed]; Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. In collaboration with PIP4K2A, has a role in mediating autophagy in times of nutrient stress (PubMed:29727621). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:29727621). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review) Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHB2", "ec_number_list": [ { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010506 regulation of autophagy;GO:0046488 phosphatidylinositol metabolic process;GO:2000786 positive regulation of autophagosome assembly;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80XI4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4S1-1", "uniprot_id": [ { "id": "PLCE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4S1", "type": "external" } ], "mass": 255047.0, "length": 2282, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "gene_name": "Plce1", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "refseq_ac": [ { "id": "NP_062534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062534", "type": "external" } ], "gene_names_uniprotkb": "Plce1; Kiaa1516; Plce", "gene_names_refseq": "4933403A21Rik; PLCepsilon; Plce1; Plce; mKIAA1516", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 3.1.4.11; PLC-epsilon-1; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; PLC-epsilon-1; phosphoinositide phospholipase C-epsilon-1", "tax_id": 10090, "disease": "nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); nephrotic syndrome type 3 (Disease Ontology:DOID:0080382); nephrotic syndrome (Disease Ontology:DOID:1184); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (mmu:74055); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11146508;12721365;12752375;15604236;15743817;16293787;17086182;21183079;21750661;31219806;32223311;32782141;34428180;36367690;36970756;38451080;40885482", "class_list": "", "function": "Phospholipase C epsilon-1 (PLCE1) mediates macrophage activation and protection against tuberculosis., [RefSeq, PubMed]; Phospholipase C-epsilon defines a PACAP-stimulated pathway for secretion in the chromaffin cell., [RefSeq, PubMed]; Phospholipase Cepsilon insufficiency causes ascending aortic aneurysm and dissection., [RefSeq, PubMed]; Plce1 deficiency in mice predisposes to glomerular damage secondary to hypertensive insults., [RefSeq, PubMed]; The induction of phospholipase Cepsilon expression may be a specific event associated with the commitment of the neural precursor cells to the neuronal lineage., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EHS1;E9Q5G0;Q3TS68;Q80TC4;Q8BZF3;Q9JKM2", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0004629 phospholipase C activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0007265 Ras protein signal transduction;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8K4S1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61409-1", "uniprot_id": [ { "id": "PDE3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61409", "type": "external" } ], "mass": 122154.0, "length": 1100, "protein_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B", "gene_name": "Pde3b", "organism": "Mouse", "refseq_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B", "refseq_ac": [ { "id": "NP_035185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035185", "type": "external" } ], "gene_names_uniprotkb": "Pde3b", "gene_names_refseq": "9830102A01Rik; Pde3b", "protein_names_uniprotkb": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; 3.1.4.17; CGI-PDE B; CGIPDE1; Cyclic GMP-inhibited phosphodiesterase B", "protein_names_refseq": "CGI-PDE B; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic GMP-inhibited phosphodiesterase B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18576); (R-MMU-165160); (R-MMU-418555)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10454575;12213348;15294162;16702214;21183079;21750661;25605945;26031333;29768196;31176020;34428180;39435735;8921398", "class_list": "", "function": "Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:10454575). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (PubMed:15294162)., [UniProtKB, UniProtKB, PubMed, PubMed]; Differential regulation of gene expression and insulin-induced activation of this enzyme in adipocytes of lean insulin-resistant IRS-1 (-/-) mice., [RefSeq, PubMed]; Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism., [RefSeq, PubMed]; Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIX5;Q9Z1J9", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051219 phosphoprotein binding;GO:0043422 protein kinase B binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001525 angiogenesis;GO:0007162 negative regulation of cell adhesion;GO:0050995 negative regulation of lipid catabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61409-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09041-1", "uniprot_id": [ { "id": "PGK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P09041", "type": "external" } ], "mass": 44853.0, "length": 417, "protein_name": "Phosphoglycerate kinase 2", "gene_name": "Pgk2", "organism": "Mouse", "refseq_name": "phosphoglycerate kinase 2", "refseq_ac": [ { "id": "NP_112467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112467", "type": "external" } ], "gene_names_uniprotkb": "Pgk2; Pgk-2", "gene_names_refseq": "Pgk-2; Pgk2; Tcp-2", "protein_names_uniprotkb": "Phosphoglycerate kinase 2; 2.7.2.3; Phosphoglycerate kinase, testis specific", "protein_names_refseq": "phosphoglycerate kinase 2; phosphoglycerate kinase, testis specific", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18663); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "18004764;19759366;2166582;24000349;25605945;2823118;29025010;29407897;31219806;33300544;34428180;3453121;35820727", "class_list": "", "function": "Catalyzes the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate and plays a role in glycolysis and gluconeogenesis (PubMed:2823118). Essential for sperm motility and male fertility but not required for the completion of spermatogenesis (PubMed:19759366)., [UniProtKB, PubMed, PubMed]; Data from studies in transgenic mice suggest that Pgk2 core promoter elements are required to direct demethylation of DNA and reconfiguration of nucleosomes in testis during sexual maturation and spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; PGK2 is expressed differently in the testes of mouse and pigs according to developmental stage., [RefSeq, PubMed]; These results identify multiple signaling and metabolic defects that are likely contributors to male infertility and the absence of progressive sperm motility seen in mice lacking GAPDHS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKV3;Q6P8V2", "ec_number_list": [ { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004618 phosphoglycerate kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P09041-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2T8-1", "uniprot_id": [ { "id": "PAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2T8", "type": "external" } ], "mass": 60518.0, "length": 535, "protein_name": "RNA polymerase II-associated factor 1 homolog", "gene_name": "Paf1", "organism": "Mouse", "refseq_name": "RNA polymerase II-associated factor 1 homolog", "refseq_ac": [ { "id": "NP_062331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062331", "type": "external" } ], "gene_names_uniprotkb": "Paf1", "gene_names_refseq": "5730511K23Rik; Paf1", "protein_names_uniprotkb": "RNA polymerase II-associated factor 1 homolog", "protein_names_refseq": "Paf1, RNA polymerase II associated factor, homolog; RNA polymerase II-associated factor 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:54624); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955); (R-MMU-8866654)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;19345177;19821493;21183079;21952136;25428506;26495903;27749823;30084848;31219806;31249142;33300544;33376128;34203471;34428180;35820727;36210013;38365788;39627609", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity)., [UniProtKB, PubMed]; PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Show that Paf1/PD2 is overexpressed in mouse embryonic stem cells (ESCs) and is involved in the maintenance of mouse ESCs., [RefSeq, PubMed]; Study shows that the Paf1 complex (Paf1C) modulates Pol II elongation rate, and loss of Paf1 results in accumulation of Ser5P in the first 20 to 30 kb of gene bodies, coinciding with reduction of histone H2B ubiquitylation specifically within this region. Moreover, reduced elongation rates provoked by Paf1 depletion resulted in defects in Pol II processivity and premature termination of transcription., [RefSeq, PubMed]; The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY97;Q9CS63;Q9JJ99", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0016055 Wnt signaling pathway;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8K2T8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0X4-1", "uniprot_id": [ { "id": "PDE3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0X4", "type": "external" } ], "mass": 124513.0, "length": 1141, "protein_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "gene_name": "Pde3a", "organism": "Mouse", "refseq_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "refseq_ac": [ { "id": "NP_061249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061249", "type": "external" } ], "gene_names_uniprotkb": "Pde3a", "gene_names_refseq": "A930022O17Rik; Pde3a", "protein_names_uniprotkb": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; 3.1.4.17; CGI-PDE A; Cyclic GMP-inhibited phosphodiesterase A", "protein_names_refseq": "CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited phosphodiesterase; cyclic GMP-inhibited phosphodiesterase A", "tax_id": 10090, "disease": "hypertension and brachydactyly syndrome (Disease Ontology:DOID:0111247); pulmonary hypertension (Disease Ontology:DOID:6432); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:54611); (R-MMU-418555)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11420239;15254586;17124499;17482796;21183079;30084848;34428180;36876489;39435735", "class_list": "", "function": "Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:11420239). Also has activity toward cUMP (By similarity). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (By similarity)., [UniProtKB, UniProtKB, PubMed]; Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure., [RefSeq, PubMed]; Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism., [RefSeq, PubMed]; Results provide evidence indicating that resumption of meiosis in vivo and in vitro requires cyclic nucleotide phosphodiesterase 3A activity., [RefSeq, PubMed]; Role of Pde3a in regulating platelet and cardiac function using subtype-selective knockout mice is reported., [RefSeq, PubMed]; These data indicate that activation of PDE3A by PKB/Akt-mediated phosphorylation plays a role in the control of PDE3A activity in mammalian oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0004119 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity;GO:0046872 metal ion binding;GO:0030284 nuclear estrogen receptor activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0060282 positive regulation of oocyte development;GO:0043066 negative regulation of apoptotic process;GO:0043116 negative regulation of vascular permeability;GO:0097190 apoptotic signaling pathway;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0X4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6BCL1-1", "uniprot_id": [ { "id": "PRAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6BCL1", "type": "external" } ], "mass": 75508.0, "length": 675, "protein_name": "PML-RARA-regulated adapter molecule 1", "gene_name": "Pram1", "organism": "Mouse", "refseq_name": "PML-RARA-regulated adapter molecule 1", "refseq_ac": [ { "id": "NP_001002842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002842", "type": "external" } ], "gene_names_uniprotkb": "Pram1", "gene_names_refseq": "Pram1", "protein_names_uniprotkb": "PML-RARA-regulated adapter molecule 1; PRAM-1", "protein_names_refseq": "PML-RARA-regulated adapter molecule 1; PRAM-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:378460)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15572693;16675706;17242355;19144319;21183079;21673516;21750661;24034616", "class_list": "", "function": "A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1/SKAP-HOM and SLP-76/Vav/PLCgamma2 signaling hubs may be critical for Yersinia survival., [RefSeq, PubMed]; Autophagy contributes to the anti-apoptotic function of the PML-RARalpha protein through inhibiting the Akt/mTOR pathway, [RefSeq, PubMed]; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P., [UniProtKB, PubMed]; Transgenic mice expressing PML-RAR alpha develop acute promyelocytic leukemia with long latency, low penetrance, and acquired cytogenetic abnormalities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QL42", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0072659 protein localization to plasma membrane;GO:0050852 T cell receptor signaling pathway;GO:0043313 regulation of neutrophil degranulation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6BCL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3T6-1", "uniprot_id": [ { "id": "PRD14_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3T6", "type": "external" } ], "mass": 63374.0, "length": 561, "protein_name": "PR domain zinc finger protein 14", "gene_name": "Prdm14", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 14", "refseq_ac": [ { "id": "NP_001074678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074678", "type": "external" } ], "gene_names_uniprotkb": "Prdm14", "gene_names_refseq": "Prdm14", "protein_names_uniprotkb": "PR domain zinc finger protein 14; 2.1.1.-; PR domain-containing protein 14", "protein_names_refseq": "PR domain zinc finger protein 14; PR domain-containing protein 14", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:383491)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18622394;19001867;19043588;20953172;21183938;26523391;27281218;30059200;34197738", "class_list": "", "function": "Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression., [RefSeq, PubMed]; Launch of the germ cell lineage in mice is orchestrated by Blimp1 and Prdm14, [RefSeq, PubMed]; Prdm14 safeguards mouse embryonic stem cells maintenance by preventing induction of extraembryonic endoderm fates., [RefSeq, PubMed]; Study implicates Prdm14 as a proto-oncogene involved in lymphoblastic lymphoma formation, [RefSeq, PubMed]; Study provides genetic evidence that Prdm14, with exclusive expression in the germ cell lineage and pluripotent cell lines, is critical for the reacquisition of potential pluripotency and successful epigenetic reprogramming., [RefSeq, PubMed]; Transcription factor that has both positive and negative roles on transcription (By similarity). Plays a role in cellular pluripotency. Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3URU1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001708 cell fate specification;GO:1902459 positive regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9Q3T6-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0I2-1", "uniprot_id": [ { "id": "PRR7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0I2", "type": "external" } ], "mass": 30354.0, "length": 269, "protein_name": "Proline-rich protein 7", "gene_name": "Prr7", "organism": "Mouse", "refseq_name": "proline-rich protein 7", "refseq_ac": [ { "id": "NP_001025467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025467", "type": "external" } ], "gene_names_uniprotkb": "Prr7", "gene_names_refseq": "Prr7; XM_484263", "protein_names_uniprotkb": "Proline-rich protein 7; Synaptic proline-rich membrane protein", "protein_names_refseq": "proline-rich protein 7; synaptic proline-rich membrane protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:432763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;27458189;27657535", "class_list": "", "function": "Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:27657535). Might promote apoptosis in T cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0044877 protein-containing complex binding;GO:0044389 ubiquitin-like protein ligase binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0002250 adaptive immune response;GO:0030217 T cell differentiation;GO:0006356 regulation of transcription by RNA polymerase I;GO:0099527 postsynapse to nucleus signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3V0I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64387-1", "uniprot_id": [ { "id": "PNOC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64387", "type": "external" } ], "mass": 20884.0, "length": 187, "protein_name": "Prepronociceptin", "gene_name": "Pnoc", "organism": "Mouse", "refseq_name": "prepronociceptin isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001192004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192004", "type": "external" } ], "gene_names_uniprotkb": "Pnoc; Npnc1", "gene_names_refseq": "N/OFQ; Npnc1; OFQ/N; Pnoc", "protein_names_uniprotkb": "Prepronociceptin; N23K/N27K; Orphanin FQ; PPNOC", "protein_names_refseq": "neuropeptide nociceptin 1; orphanin FQ; prepronociceptin isoform 2 preproprotein; proorphanin", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); cocaine abuse (Disease Ontology:DOID:809); neonatal abstinence syndrome (Disease Ontology:DOID:9828)", "pathway": " (mmu:18155); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "7503733;8645247;8663129;8670093;8710928;9601687", "class_list": "", "function": "Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia., [UniProtKB, UniProtKB]; Has potent analgesic activity., [UniProtKB, PubMed]; Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. When administered intracerebroventricularly, nociceptin induces hyperalgesia and decreases locomotor activity., [UniProtKB]; This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61105;Q61938", "ec_number_list": [], "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0048018 receptor ligand activity;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0098828 modulation of inhibitory postsynaptic potential;GO:0007218 neuropeptide signaling pathway;GO:0045471 response to ethanol;GO:0098815 modulation of excitatory postsynaptic potential;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64387-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5J9-1", "uniprot_id": [ { "id": "PRAF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5J9", "type": "external" } ], "mass": 21558.0, "length": 188, "protein_name": "PRA1 family protein 3", "gene_name": "Arl6ip5", "organism": "Mouse", "refseq_name": "PRA1 family protein 3", "refseq_ac": [ { "id": "NP_075368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075368", "type": "external" } ], "gene_names_uniprotkb": "Arl6ip5; Aip5; Jwa; Pra2; Praf3", "gene_names_refseq": "5930404D22Rik; Aip-5; Arl6ip5; Gtrap3-18; addiscin", "protein_names_uniprotkb": "PRA1 family protein 3; ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Addicsin; Aip-5; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; Prenylated Rab acceptor protein 2; Protein JWa", "protein_names_refseq": "ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; PRA1 family protein 3; addicsin; glutamate transporter EAAC1-interacting protein; prenylated Rab acceptor protein 2; protein JWa", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:65106); (R-MMU-210500)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10508919;12119102;12438930;12562531;18684713;28428137;28904020;34428180;39927985", "class_list": "", "function": "98% identity with that of rat GTRAP3-18; upregulated in the amygdala by repeated administration of morphine, [RefSeq, PubMed]; Glutamate transporter-associated protein 3-18 (GTRAP3-18), an anchor protein that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC. GTRAP3-18-deficient mice showed hypophagia, lean bodies, and lower blood glucose, insulin, and leptin levels with increased serum and brain alpha-MSH levels, leading to AMPK inhibition., [RefSeq, PubMed]; Inhibits EAAT3-mediated glutamate uptake; highly conserved protein and genomic organization amongst vertebrates, [RefSeq, PubMed]; Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis. Erratum:[Toxicol Lett. 2019 Jan;300:119. doi: 10.1016/j.toxlet.2018.08.014. PMID: 30190152], [RefSeq, PubMed]; Regulates intracellular concentrations of taurine and glutamate (By similarity). Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner (PubMed:12119102, PubMed:18684713). Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2Q1;Q9D838;Q9DB37;Q9WUG9", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0002037 negative regulation of L-glutamate import across plasma membrane;GO:0007611 learning or memory;GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R5J9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MR9-1", "uniprot_id": [ { "id": "PPR3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MR9", "type": "external" } ], "mass": 121435.0, "length": 1089, "protein_name": "Protein phosphatase 1 regulatory subunit 3A", "gene_name": "Ppp1r3a", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 3A", "refseq_ac": [ { "id": "NP_536712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536712", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3a; Pp1g", "gene_names_refseq": "GM; Ppp1r3a; RG1; RGL", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3A; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase type-1 glycogen targeting subunit; RG1", "protein_names_refseq": "protein phosphatase 1 glycogen-associated regulatory subunit; protein phosphatase 1 regulatory subunit 3A; protein phosphatase 1, regulatory (inhibitor) subunit 3A; protein phosphatase type-1 glycogen targeting subunit", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:140491)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11283248;11361130;12606498;21183079;31235787;35820727;36288343;37102430;37507081;39927985", "class_list": "glycogene", "function": "Disruption of the Ppp1r3a gene does not result in either fat deposition or insulin resistance, but PPP1r3a is essential for control of glycogen metabolism by exercise., [RefSeq, PubMed]; Mice lacking Ppp1r3a are protected against pressure-overload heart failure. Condition-specific cardiac regulatory gene networks identify disease-driven changes in local and global topology and pathway organization, illuminating Ppp1r3a as a novel predicted heart failure regulator. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that dysfunction of subunit PPP1R3A of protein phosphatase 1 leads to weight gain, increased fat deposition and insulin resistance, [RefSeq, PubMed]; Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt., [RefSeq, PubMed]; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 71, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32MS0;Q8BUJ4;Q8BUL0", "ec_number_list": [], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0016020 membrane", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99MR9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAA4-1", "uniprot_id": [ { "id": "PRS37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAA4", "type": "external" } ], "mass": 26698.0, "length": 237, "protein_name": "Probable inactive serine protease 37", "gene_name": "Prss37", "organism": "Mouse", "refseq_name": "probable inactive serine protease 37 precursor", "refseq_ac": [ { "id": "NP_080593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080593", "type": "external" } ], "gene_names_uniprotkb": "Prss37; Tryx2", "gene_names_refseq": "1700016G05Rik; Prss37; Tryx2", "protein_names_uniprotkb": "Probable inactive serine protease 37; Probable inactive trypsin-X2", "protein_names_refseq": "probable inactive serine protease 37 precursor; probable inactive serine protease 37; probable inactive trypsin-X2; protease, serine 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:67690)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23553430;25921412;34028541;35471551;36288343", "class_list": "", "function": "Dissecting the PRSS37 interactome and potential mechanisms leading to ADAM3 loss in PRSS37-null sperm., [RefSeq, PubMed]; Interstrain hybridization obtained Prss37(-/-)EGFP(tg/+) males produced sperm with impaired oviduct-migrating ability as visualized under fluorescence microscope, compared with Prss37(+/+)EGFP(tg/+) counterparts, [RefSeq, PubMed]; PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis., [RefSeq, PubMed]; Plays a role in male fertility (PubMed:23553430). May have a role in sperm migration or binding to zona-intact eggs (PubMed:23553430). Involved in the activation of the proacrosin/acrosin system (By similarity)., [UniProtKB, UniProtKB, PubMed]; Prss37 deficiency causes the absence of mature Adam3 in sperm and a defect in sperm migration from uterus into oviduct, which mainly accounts for male infertility of Prss37-null mice Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUH3", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0006508 proteolysis;GO:0007339 binding of sperm to zona pellucida;GO:0016477 cell migration;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DAA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJN0-1", "uniprot_id": [ { "id": "POLH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJN0", "type": "external" } ], "mass": 76167.0, "length": 694, "protein_name": "DNA polymerase eta", "gene_name": "Polh", "organism": "Mouse", "refseq_name": "DNA polymerase eta isoform 1", "refseq_ac": [ { "id": "NP_109640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109640", "type": "external" } ], "gene_names_uniprotkb": "Polh; Rad30a; Xpv", "gene_names_refseq": "Polh; RAD30A; XPV", "protein_names_uniprotkb": "DNA polymerase eta; 2.7.7.7; RAD30 homolog A; Xeroderma pigmentosum variant type protein homolog", "protein_names_refseq": "DNA polymerase eta isoform 1; DNA-directed DNA polymerase eta; RAD30 homolog A; xeroderma pigmentosum variant type protein homolog", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); female breast cancer (Disease Ontology:DOID:0050671); xeroderma pigmentosum variant type (Disease Ontology:DOID:0110847)", "pathway": " (mmu:80905); (R-MMU-110320); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10871396;11554790;12119399;14657033;21750661;25733082;26240351;26727495", "class_list": "", "function": "DNA polymerase fidelity and specificity, [RefSeq, PubMed]; DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10871396). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (By similarity). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10871396). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis. Targets POLI to replication foci (By similarity)., [UniProtKB, PubMed, UniProtKB]; Inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hypermutation (SHM) of Ig genes, [RefSeq, PubMed]; Increase in UV-induced mutations at both G:C and A:T pairs associated with PolH deficiency suggests that PolH contributes to accurate translesion synthesis (TLS) past both T- & C-containing dimers., [RefSeq, PubMed]; The functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta. Publication Status: Online-Only, [RefSeq, PubMed]; XP-V has a role in adipose tissue senescence and metabolic syndrome, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJJ2", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0005657 replication fork", "go_biological_process": "GO:0009314 response to radiation;GO:0019985 translesion synthesis;GO:0000731 DNA synthesis involved in DNA repair;GO:0042276 error-prone translesion synthesis;GO:0006301 DNA damage tolerance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJN0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZZ8-1", "uniprot_id": [ { "id": "RAB38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZZ8", "type": "external" } ], "mass": 23776.0, "length": 211, "protein_name": "Ras-related protein Rab-38", "gene_name": "Rab38", "organism": "Mouse", "refseq_name": "ras-related protein Rab-38", "refseq_ac": [ { "id": "NP_082514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082514", "type": "external" } ], "gene_names_uniprotkb": "Rab38", "gene_names_refseq": "2310011F14Rik; Rab38; cht", "protein_names_uniprotkb": "Ras-related protein Rab-38; 3.6.5.2", "protein_names_refseq": "RAB38, member of RAS oncogene family; chocolate; ras-related protein Rab-38", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:72433); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11917121;21187289;21750661;26620560;31399401;36430618;37625589;37793839", "class_list": "", "function": "Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes., [RefSeq, PubMed]; Our study demonstrates the absence of impact of RAB38 or RAB32 single deficiency in platelet biogenesis and function resulting from full redundancy, and characterized a new mouse model mimicking HPS devoid of DG content., [RefSeq, PubMed]; Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts., [RefSeq, PubMed]; Rab32/38-Dependent and -Independent Transport of Tyrosinase to Melanosomes in B16-F1 Melanoma Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators in vesicle trafficking., [UniProtKB, UniProtKB]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB38 plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (PubMed:21187289). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7E8", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0035651 AP-3 adaptor complex binding;GO:0036461 BLOC-2 complex binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903232 melanosome assembly;GO:0090383 phagosome acidification;GO:0006886 intracellular protein transport;GO:2001247 positive regulation of phosphatidylcholine biosynthetic process;GO:0060155 platelet dense granule organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8QZZ8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTL2-1", "uniprot_id": [ { "id": "RAB25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTL2", "type": "external" } ], "mass": 23473.0, "length": 213, "protein_name": "Ras-related protein Rab-25", "gene_name": "Rab25", "organism": "Mouse", "refseq_name": "ras-related protein Rab-25", "refseq_ac": [ { "id": "NP_058595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058595", "type": "external" } ], "gene_names_uniprotkb": "Rab25", "gene_names_refseq": "Rab25", "protein_names_uniprotkb": "Ras-related protein Rab-25; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-25", "tax_id": 10090, "disease": "", "pathway": " (mmu:53868); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10708602;21750661;22696678;30084848;31144312;34428180;36565104;38401686;39424096", "class_list": "", "function": "A small Rho GTPase RAB25 with a potential role in chemotherapy resistance in pancreatic cancer., [RefSeq, PubMed]; Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury: Impact on the regulation of germ cell proliferation and apoptosis., [RefSeq, PubMed]; Loss of Rab25 promotes the development and neoplastic transition of skin squamous cell carcinoma through dysregulation of integrin trafficking., [RefSeq, PubMed]; Rab25 is involved in hypospadias via the beta1 integrin/EGFR pathway., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (By similarity). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (PubMed:22696678). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1P3", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0031260 pseudopodium membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0031268 pseudopodium organization;GO:0008284 positive regulation of cell population proliferation;GO:0015031 protein transport;GO:0060627 regulation of vesicle-mediated transport;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WTL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHL4-1", "uniprot_id": [ { "id": "RAI3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHL4", "type": "external" } ], "mass": 40101.0, "length": 356, "protein_name": "Retinoic acid-induced protein 3", "gene_name": "Gprc5a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gprc5a; Rai3; Raig1", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid-induced protein 3; G protein-coupled receptor family C group 5 member A; RAIG-1; Retinoic acid-induced gene 1 protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:232431)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14706456;15592455;18000218;21750661;25428506;25744720;31219806;34887587", "class_list": "", "function": "Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provides evidence for a possible interaction between retinoid and G protein signaling pathways. Functions as a negative modulator of EGFR signaling (PubMed:25744720). Acts as a lung tumor suppressor (PubMed:18000218)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K067;Q8K1G5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0070062 extracellular exosome;GO:0031982 vesicle", "go_biological_process": "GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BHL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P99028-1", "uniprot_id": [ { "id": "QCR6_MOUSE", "url": "https://www.uniprot.org/uniprot/P99028", "type": "external" } ], "mass": 10435.0, "length": 89, "protein_name": "Cytochrome b-c1 complex subunit 6, mitochondrial", "gene_name": "Uqcrh", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit 6, mitochondrial", "refseq_ac": [ { "id": "NP_079917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079917", "type": "external" } ], "gene_names_uniprotkb": "Uqcrh", "gene_names_refseq": "2210416J04Rik; 2310021J10Rik; 2610041P16Rik; Uqcrh", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 6, mitochondrial; Complex III subunit 6; Complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein", "protein_names_refseq": "complex III subunit 6; complex III subunit VIII; cytochrome C1, nonheme 11 kDa protein; cytochrome b-c1 complex subunit 6, mitochondrial; cytochrome c1 non-heme 11 kDa protein; mitochondrial hinge protein; ubiquinol-cytochrome c reductase complex 11 kDa protein", "tax_id": 10090, "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139)", "pathway": " (mmu:66576); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "19026783;22872234;23576753;31219806;34428180;34616041;34750991;36288343;36565314;37230398;38575788", "class_list": "", "function": "AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease., [RefSeq, PubMed]; Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes., [RefSeq, PubMed]; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed, PubMed]; Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542K2;Q9CQP4", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P99028-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D855-1", "uniprot_id": [ { "id": "QCR7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D855", "type": "external" } ], "mass": 13527.0, "length": 111, "protein_name": "Cytochrome b-c1 complex subunit 7", "gene_name": "Uqcrb", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Uqcrb", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 7; Complex III subunit 7; Complex III subunit VII; Ubiquinol-cytochrome c reductase complex 14 kDa protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "mitochondrial complex III deficiency nuclear type 3 (Disease Ontology:DOID:0080112); depressive disorder (Disease Ontology:DOID:1596); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19026783;23576753;23806337;34428180;34616041;36288343;37507081", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2E2", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D855-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP71-1", "uniprot_id": [ { "id": "RAI14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP71", "type": "external" } ], "mass": 108852.0, "length": 979, "protein_name": "Ankycorbin", "gene_name": "Rai14", "organism": "Mouse", "refseq_name": "ankycorbin isoform 1", "refseq_ac": [ { "id": "NP_001159880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159880", "type": "external" } ], "gene_names_uniprotkb": "Rai14; Kiaa1334; Norpeg", "gene_names_refseq": "1700008J19Rik; 1700020L11Rik; Ankycorbin; Norpeg; Rai14; mKIAA1334", "protein_names_uniprotkb": "Ankycorbin; Ankyrin repeat and coiled-coil structure-containing protein; Novel retinal pigment epithelial cell protein; Retinoic acid-induced protein 14; p125", "protein_names_refseq": "NORPEG-like protein; ankycorbin isoform 1; ankyrin repeat and coiled-coil structure-containing protein; novel retinal pigment epithelial cell protein; p125; retinoic acid-induced protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:75646)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11042181;11168586;16806700;21183079;21750661;22645316;22872234;24788674;28528544;31219806;34428180;34887587;36210013", "class_list": "", "function": "Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URT3;Q6ZPT6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0001650 fibrillar center", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EP71-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64374-1", "uniprot_id": [ { "id": "RGN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64374", "type": "external" } ], "mass": 33407.0, "length": 299, "protein_name": "Regucalcin", "gene_name": "Rgn", "organism": "Mouse", "refseq_name": "regucalcin", "refseq_ac": [ { "id": "NP_033086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033086", "type": "external" } ], "gene_names_uniprotkb": "Rgn; Smp30", "gene_names_refseq": "GNL; RC; Rgn; SMP-30; SMP30", "protein_names_uniprotkb": "Regucalcin; 3.1.1.17; GNL; Gluconolactonase; RC; SMP-30; Senescence marker protein 30", "protein_names_refseq": "gluconolactonase; regucalcin; senescence marker protein 30", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19733)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12368201;14975739;16585534;23349732;23806337;31219806;33323968;34428180;36434042;37001596;37453647;37828378;8765750;9278263", "class_list": "", "function": "Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)., [UniProtKB, PubMed, PubMed]; Regucalcin promotes dormancy of prostate cancer. Erratum:[Oncogene. 2025 Feb;44(4):271. doi: 10.1038/s41388-024-03216-9. PMID: 39528817], [RefSeq, PubMed]; Results demonstrate that SMP30 acts to protect cells from apoptosis, [RefSeq, PubMed]; SMP30-mediated synthesis of vitamin C activates the liver PPARalpha/FGF21 axis to regulate thermogenesis in mice., [RefSeq, PubMed]; The inflammatory macrophages repress the growth of bone metastatic human prostate cancer cells via TNF-alpha and IL-6 signaling: Involvement of cell signaling regulator regucalcin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFC8;Q3UJG3;Q60944", "ec_number_list": [ { "id": "3.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.17", "type": "external" } ], "go_molecular_function": "GO:0004341 gluconolactonase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1901318 negative regulation of flagellated sperm motility;GO:1903011 negative regulation of bone development;GO:1903611 negative regulation of calcium-dependent ATPase activity;GO:1903625 negative regulation of DNA catabolic process;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64374-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFT4-1", "uniprot_id": [ { "id": "RHG20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IFT4", "type": "external" } ], "mass": 131374.0, "length": 1182, "protein_name": "Rho GTPase-activating protein 20", "gene_name": "Arhgap20", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 20", "refseq_ac": [ { "id": "NP_780744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780744", "type": "external" } ], "gene_names_uniprotkb": "Arhgap20; Kiaa1391", "gene_names_refseq": "6530403F17Rik; A530023E23Rik; Arhgap20; RARhoGAP; mKIAA1391", "protein_names_uniprotkb": "Rho GTPase-activating protein 20; RA and RhoGAP domain-containing protein; RARhoGAP; Rho-type GTPase-activating protein 20", "protein_names_refseq": "RA and RhoGAP domain-containing protein; rho GTPase-activating protein 20; rho-type GTPase-activating protein 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:244867); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14532992;15234003;18937323;21183079;21750661;40021952", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB]; Human KIAA1391 gene and mouse Kiaa1391 gene encode RhoGAP proteins with RA domain and two ANXL repeats, [RefSeq, PubMed]; Results are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPS4;Q8BLZ7;Q8BXI4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IFT4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ32-1", "uniprot_id": [ { "id": "RGMC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQ32", "type": "external" } ], "mass": 44848.0, "length": 420, "protein_name": "Hemojuvelin", "gene_name": "Hjv", "organism": "Mouse", "refseq_name": "hemojuvelin precursor", "refseq_ac": [ { "id": "NP_081402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081402", "type": "external" } ], "gene_names_uniprotkb": "Hjv; Hfe2; Rgmc", "gene_names_refseq": "2310035L15Rik; 5230400G09Rik; DL-M; Hfe2; Hjv; Rgmc; hemojuvelin", "protein_names_uniprotkb": "Hemojuvelin; Hemochromatosis type 2 protein homolog; Hemojuvelin BMP coreceptor; RGM domain family member C", "protein_names_refseq": "RGM domain family member C; hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein homolog; hemojuvelin BMP coreceptor; hemojuvelin precursor; repulsive guidance molecule C", "tax_id": 10090, "disease": "hemochromatosis type 2A (Disease Ontology:DOID:0111027); hemochromatosis (Disease Ontology:DOID:2352)", "pathway": " (mmu:69585)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14678836;16604073;19252486;21183079;36675185;38310100", "class_list": "", "function": "Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis., [UniProtKB, PubMed, PubMed]; Exclusive expression in the muscle cell lineage., [RefSeq, PubMed]; Genetic Iron Overload Hampers Development of Cutaneous Leishmaniasis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEU7;Q8K1D4;Q9D741", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0098821 BMP receptor activity;GO:0036122 BMP binding;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0030509 BMP signaling pathway;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQ32-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZJ1-1", "uniprot_id": [ { "id": "RAP2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZJ1", "type": "external" } ], "mass": 20642.0, "length": 183, "protein_name": "Ras-related protein Rap-2a", "gene_name": "Rap2a", "organism": "Mouse", "refseq_name": "ras-related protein Rap-2a", "refseq_ac": [ { "id": "NP_083795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083795", "type": "external" } ], "gene_names_uniprotkb": "Rap2a", "gene_names_refseq": "5830461H18Rik; Rap2a", "protein_names_uniprotkb": "Ras-related protein Rap-2a; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-2a", "tax_id": 10090, "disease": "", "pathway": " (mmu:76108)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10926822;12133960;12904304;14701796;18701680;19061864;20159449;27221778;30851634;33300544;34428180;36366779;9523700", "class_list": "", "function": "BCR-induced phosphorylation of Akt on critical activating sites was increased 2- to 3-fold when Rap1 and Rap2 activation was blocked, [RefSeq, PubMed]; Loss of RAP2A Aggravates Cartilage Degradation in TMJOA via YAP Signaling., [RefSeq, PubMed]; Rap2 has a role in regulation of integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes, [RefSeq, PubMed]; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading., [UniProtKB, PubMed, PubMed, PubMed]; The small GTP-binding protein Rap2a is a common target of both miR-9 and miR-124. miR-9 and miR-124 together, but neither miRNA alone, strongly suppressed Rap2a, thereby promoting neuronal differentiation of neural stem cells and dendritic branching of differentiated neurons. Rap2a also diminished the dendritic complexity of mature neurons by decreasing the levels of pAKT and pGSK3beta. Publication Status: Online-Only, [RefSeq, PubMed]; These results implicate Rap2a in TLR-mediated responses by contributing to balanced NF-kappaB activity status in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USK1;Q7TSK4;Q810A2;Q9D3D5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030335 positive regulation of cell migration;GO:0048814 regulation of dendrite morphogenesis;GO:0030336 negative regulation of cell migration;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80ZJ1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRH3-1", "uniprot_id": [ { "id": "RHG19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRH3", "type": "external" } ], "mass": 55734.0, "length": 494, "protein_name": "Rho GTPase-activating protein 19", "gene_name": "Arhgap19", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 19 isoform 2", "refseq_ac": [ { "id": "NP_001156967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156967", "type": "external" } ], "gene_names_uniprotkb": "Arhgap19", "gene_names_refseq": "4933411B03Rik; Arhgap19; mFLJ00368", "protein_names_uniprotkb": "Rho GTPase-activating protein 19; Rho-type GTPase-activating protein 19", "protein_names_refseq": "rho GTPase-activating protein 19 isoform 2; rho GTPase-activating protein 19; rho-type GTPase-activating protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:71085); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16479539;21183079;21750661;31219806;33407571;36210013", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB, UniProtKB]; Has GTPase activator activity toward RHOA; RHOA activation results in GTP hydrolysis and conversion from an active GTP-bound to an inactive GDP-bound state. Lacks GTPase activator activity toward RAC1 or CDC42., [UniProtKB, UniProtKB]; Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EI55;Q0VGS7;Q5DU53;Q9D468", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BRH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YM2-1", "uniprot_id": [ { "id": "RHG35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YM2", "type": "external" } ], "mass": 170393.0, "length": 1499, "protein_name": "Rho GTPase-activating protein 35", "gene_name": "Arhgap35", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 35", "refseq_ac": [ { "id": "NP_766327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766327", "type": "external" } ], "gene_names_uniprotkb": "Arhgap35; Grlf1; Kiaa1722; P190A; p190ARHOGAP", "gene_names_refseq": "6430596G11Rik; Arhgap35; Grlf1; mKIAA1722; p190A; p190RhoGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 35; Glucocorticoid receptor DNA-binding factor 1", "protein_names_refseq": "P190 RhoGAP; glucocorticoid receptor DNA-binding factor 1; rho GTPase-activating protein 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:232906); (R-MMU-416550); (R-MMU-8849471); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 16, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11044403;11283609;12446743;16452087;16513268;16971514;17242355;17947660;18034455;18502760;20675588;21183079;21945077;26859289;30902550;34258149;34428180;35820727;36210013;37507081", "class_list": "", "function": "HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Publication Status: Online-Only, [RefSeq, PubMed]; P190RhoGAP is a critical regulator of motor axon guidance. Rather than acting as a compulsory signal relay, p190RhoGAP uses a non-conventional GAP-independent mode to transiently suppress attraction to Netrin-1 while motor axons exit the spinal cord. Once in the periphery, a subset of axons requires p190RhoGAP-mediated inhibition of Rho signaling to target specific muscles., [RefSeq, PubMed]; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:16971514). This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (PubMed:11044403, PubMed:11283609, PubMed:18502760, PubMed:21945077). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (PubMed:16971514). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (PubMed:11283609). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (PubMed:11044403, PubMed:18502760, PubMed:26859289). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (PubMed:21945077). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGY1;Q69ZC4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0097485 neuron projection guidance;GO:0008064 regulation of actin polymerization or depolymerization;GO:0006351 DNA-templated transcription;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q91YM2-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921J2-1", "uniprot_id": [ { "id": "RHEB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921J2", "type": "external" } ], "mass": 20451.0, "length": 184, "protein_name": "GTP-binding protein Rheb", "gene_name": "Rheb", "organism": "Mouse", "refseq_name": "GTP-binding protein Rheb", "refseq_ac": [ { "id": "NP_444305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444305", "type": "external" } ], "gene_names_uniprotkb": "Rheb", "gene_names_refseq": "Rheb1; Rheb", "protein_names_uniprotkb": "GTP-binding protein Rheb; 3.6.5.-; Ras homolog enriched in brain", "protein_names_refseq": "GTP-binding protein Rheb; RAS-homolog enriched in brain", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); tuberous sclerosis (Disease Ontology:DOID:13515); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19744); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "12820960;16046393;16631613;21321084;21336308;24648513;37507081;38411613;39422647", "class_list": "", "function": "ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes., [RefSeq, PubMed]; Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12820960, PubMed:16631613, PubMed:21321084, PubMed:24648513). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (By similarity). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (By similarity). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (By similarity). Has low intrinsic GTPase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. Publication Status: Online-Only, [RefSeq, PubMed]; Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0000045 autophagosome assembly;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0009615 response to virus;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q921J2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC04-3", "uniprot_id": [ { "id": "RGS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC04", "type": "external" } ], "mass": 106219.0, "length": 966, "protein_name": "Regulator of G protein signaling 3", "gene_name": "Rgs3", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 3 isoform 3", "refseq_ac": [ { "id": "NP_001075119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075119", "type": "external" } ], "gene_names_uniprotkb": "Rgs3", "gene_names_refseq": "4930506N09Rik; C2PA-RGS3; C2pa; PDZ-RGS3; RGS3S; Rgs3", "protein_names_uniprotkb": "Regulator of G protein signaling 3; C2PA; RGS3", "protein_names_refseq": "C2 membrane binding, PDZ protein/protein interaction, ATP/GTP binding domains; regulator of G-protein signaling 3 isoform 3", "tax_id": 10090, "disease": "lesion of sciatic nerve (Disease Ontology:DOID:12528); bladder disease (Disease Ontology:DOID:365)", "pathway": " (mmu:50780); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10779778;11034339;11301003;12210723;20629178;21183079;28845525;34428180", "class_list": "", "function": "Down-regulates signaling from heterotrimeric G proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G protein-mediated release of inositol phosphates and activation of MAP kinases., [UniProtKB, PubMed, PubMed]; RGS3 may provide protection against pathological changes of adventitial fibroblasts and the development of atherosclerosis by inhibiting TGF-beta1/Smad signaling., [RefSeq, PubMed]; Results reveal an essential role of PDZ-RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking PDZ-RGS3 to ephrin-B reverse signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SRB1;Q5SRB4;Q5SRB8;Q8CEE3;Q8VI25;Q925G9;Q9JL22;Q9JL23;Q9QXA2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DC04-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K070-1", "uniprot_id": [ { "id": "SAM14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K070", "type": "external" } ], "mass": 45102.0, "length": 417, "protein_name": "Sterile alpha motif domain-containing protein 14", "gene_name": "Samd14", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 14 isoform 2", "refseq_ac": [ { "id": "NP_666137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666137", "type": "external" } ], "gene_names_uniprotkb": "Samd14", "gene_names_refseq": "Samd14", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 14; SAM domain-containing protein 14", "protein_names_refseq": "SAM domain-containing protein 14; sterile alpha motif domain-containing protein 14 isoform 2; sterile alpha motif domain-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:217125)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;17114649;21183079;21750661;28787589;35713400;37722652;40885482", "class_list": "", "function": "Functional requirements for a Samd14-capping protein complex in stress erythropoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; Physiological and regenerative functions of sterile-alpha motif protein-14 in hematopoiesis., [RefSeq, PubMed]; The Samd14 enhancer is essential for erythrocyte regeneration in severe anemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWB7;Q8BHE2;Q8C8N5", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0030425 dendrite", "go_biological_process": "GO:0007015 actin filament organization;GO:0019722 calcium-mediated signaling;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K070-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYR8-1", "uniprot_id": [ { "id": "S41A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYR8", "type": "external" } ], "mass": 62305.0, "length": 573, "protein_name": "Solute carrier family 41 member 2", "gene_name": "Slc41a2", "organism": "Mouse", "refseq_name": "solute carrier family 41 member 2", "refseq_ac": [ { "id": "NP_796362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796362", "type": "external" } ], "gene_names_uniprotkb": "Slc41a2", "gene_names_refseq": "A230035L05Rik; SLC41A1-L1; Slc41a2", "protein_names_uniprotkb": "Solute carrier family 41 member 2", "protein_names_refseq": "solute carrier family 41 member 2", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:338365); (R-MMU-425410)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15809054;21183079;21750661;34428180", "class_list": "", "function": "Acts as a plasma-membrane magnesium transporter (PubMed:15809054). Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+) (PubMed:15809054)., [UniProtKB, PubMed]; SLC41A2 is a Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells Erratum:[Biochem Biophys Res Commun. 2007 May 11;356(3):822], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0030001 metal ion transport;GO:0006826 iron ion transport;GO:0006828 manganese ion transport;GO:0015675 nickel cation transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BYR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35874-1", "uniprot_id": [ { "id": "SATT_MOUSE", "url": "https://www.uniprot.org/uniprot/O35874", "type": "external" } ], "mass": 56062.0, "length": 532, "protein_name": "Neutral amino acid transporter A", "gene_name": "Slc1a4", "organism": "Mouse", "refseq_name": "neutral amino acid transporter A isoform 1", "refseq_ac": [ { "id": "NP_061349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061349", "type": "external" } ], "gene_names_uniprotkb": "Slc1a4; Asct1; Satt", "gene_names_refseq": "ASCT-1; ASCT1; SATT; Slc1a4", "protein_names_uniprotkb": "Neutral amino acid transporter A; ASCT-1; Alanine/serine/cysteine/threonine transporter 1; Solute carrier family 1 member 4", "protein_names_refseq": "alanine/serine/cysteine/threonine transporter 1; neutral amino acid transporter A isoform 1; neutral amino acid transporter A; solute carrier family 1 member 4", "tax_id": 10090, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); spastic tetraplegia, thin corpus callosum, and progressive microcephaly (Disease Ontology:DOID:0070537); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:55963); (R-MMU-352230)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12050356;19144319;19349973;19656770;21183079;21750661;26495903;30185558;33300544;34428180;35195906;36283621;36367657;37238689", "class_list": "", "function": "Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex., [RefSeq, PubMed]; Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease., [RefSeq, PubMed]; Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity) (PubMed:30185558). Exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine and L-alanine in a bidirectional way (By similarity) (PubMed:30185558). Involved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. In astrocytes at excitatory synapses, mediates electrogenic D-serine influx coupled to L-serine efflux and L-serine shuttling to neurons for de novo D-serine synthesis (PubMed:30185558, PubMed:37238689). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Used as receptor by HERV-W Env glycoprotein when their sites for N-glycosylation are eliminated by mutagenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0015195 L-threonine transmembrane transporter activity;GO:0034590 L-hydroxyproline transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0015824 proline transport;GO:0015825 L-serine transport;GO:0015826 threonine transport;GO:0034589 hydroxyproline transport;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O35874-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFE6-1", "uniprot_id": [ { "id": "S38A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFE6", "type": "external" } ], "mass": 55503.0, "length": 504, "protein_name": "Sodium-coupled neutral amino acid symporter 2", "gene_name": "Slc38a2", "organism": "Mouse", "refseq_name": "sodium-coupled neutral amino acid symporter 2 isoform 1", "refseq_ac": [ { "id": "NP_780330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780330", "type": "external" } ], "gene_names_uniprotkb": "Slc38a2; Ata2; Kiaa1382; Sat2; Snat2", "gene_names_refseq": "5033402L14Rik; ATA2; SAT2; SNAT2; Slc38a2; mKIAA1382", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid symporter 2; Amino acid transporter A2; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2", "protein_names_refseq": "amino acid system A transporter; amino acid transporter A2; sodium-coupled neutral amino acid symporter 2 isoform 1; sodium-coupled neutral amino acid symporter 2; sodium-coupled neutral amino acid transporter 2; system A amino acid transporter 2; system A transporter 1; system N amino acid transporter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67760); (R-MMU-210500); (R-MMU-352230)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;11834730;12971909;16075062;16365304;17003038;17050538;18034455;19144319;20173027;21183079;22872234;25428506;26495903;27802388;28011936;30084848;30779550;31219806;32152506;34203471;34406367;34428180;35820727;36722887;37828378;38071217", "class_list": "", "function": "Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. (ATA2 or SAT2), [RefSeq, PubMed]; Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:34406367). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (PubMed:16365304). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (PubMed:34406367)., [UniProtKB, PubMed, UniProtKB, PubMed]; The NERP-4-SNAT2 axis regulates pancreatic beta-cell maintenance and function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEX3;Q6PFR1;Q6ZPS7;Q810U9;Q8CC66;Q8CD21", "ec_number_list": [], "go_molecular_function": "GO:0005298 proline:sodium symporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0015824 proline transport;GO:0015825 L-serine transport;GO:0031460 glycine betaine transport;GO:0032328 alanine transport", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8CFE6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1T2-1", "uniprot_id": [ { "id": "SAE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1T2", "type": "external" } ], "mass": 38620.0, "length": 350, "protein_name": "SUMO-activating enzyme subunit 1", "gene_name": "Sae1", "organism": "Mouse", "refseq_name": "SUMO-activating enzyme subunit 1 isoform a", "refseq_ac": [ { "id": "NP_001272820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272820", "type": "external" } ], "gene_names_uniprotkb": "Sae1; Aos1; Sua1; Ubl1a1; Uble1a", "gene_names_refseq": "2400010M20Rik; 2610044L12Rik; AOS1; D7Ertd177e; HSPC140; Sae1; Sua1; Uble1a", "protein_names_uniprotkb": "SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A", "protein_names_refseq": "SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1 isoform a; SUMO-activating enzyme subunit 1; ubiquitin-like (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme subunit 1; ubiquitin-like 1-activating enzyme E1A", "tax_id": 10090, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (mmu:56459); (R-MMU-3065676); (R-MMU-3065678)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11481243;19224205;20173027;23806337;25605945;27802388;29187734;30084848;30779550;31219806;34428180;35820727;37507081", "class_list": "", "function": "The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRG9;Q3TWJ0;Q9CSW9", "ec_number_list": [], "go_molecular_function": "GO:0019948 SUMO activating enzyme activity;GO:0046982 protein heterodimerization activity;GO:0043008 ATP-dependent protein binding;GO:0044388 small protein activating enzyme binding", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016925 protein sumoylation;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R1T2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMC0-1", "uniprot_id": [ { "id": "AFG2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMC0", "type": "external" } ], "mass": 97256.0, "length": 893, "protein_name": "ATPase family gene 2 protein homolog A", "gene_name": "Afg2a", "organism": "Mouse", "refseq_name": "ATPase family gene 2 protein homolog A isoform 1", "refseq_ac": [ { "id": "NP_001156983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156983", "type": "external" } ], "gene_names_uniprotkb": "Afg2a; Spaf; Spata5", "gene_names_refseq": "2510048F20Rik; Afg2a; Spaf; Spata5", "protein_names_uniprotkb": "ATPase family gene 2 protein homolog A; 3.6.4.10; AFG2 AAA ATPase homolog A; Ribosome biogenesis protein SPATA5; Spermatogenesis-associated factor protein; Spermatogenesis-associated protein 5", "protein_names_refseq": "ATPase family gene 2 protein homolog A isoform 1; ATPase family gene 2 protein homolog A; ATPase family protein 2 homolog; ribosome biogenesis protein SPATA5; spermatogenesis associated 5; spermatogenesis-associated factor protein; spermatogenesis-associated protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:57815)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10734318;17242355;21183079;21750661;31219806;34428180;34887587;36210013", "class_list": "", "function": "ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (By similarity). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (PubMed:10734318)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACU2;A3KG23;A3KG24;Q9CXZ7;Q9Z2K7", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:1990275 preribosome binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042273 ribosomal large subunit biogenesis;GO:0006260 DNA replication;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UMC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55131-1", "uniprot_id": [ { "id": "SEPT7_MOUSE", "url": "https://www.uniprot.org/uniprot/O55131", "type": "external" } ], "mass": 50550.0, "length": 436, "protein_name": "Septin-7", "gene_name": "Septin7", "organism": "Mouse", "refseq_name": "septin-7 isoform 2", "refseq_ac": [ { "id": "NP_001192296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192296", "type": "external" } ], "gene_names_uniprotkb": "Septin7; Cdc10; Sept7", "gene_names_refseq": "Cdc10; E430034N22; Sept7; Septin7", "protein_names_uniprotkb": "Septin-7; CDC10 protein homolog", "protein_names_refseq": "CDC10 protein homolog; cell division cycle 10 homolog; septin-7 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235072); (R-MMU-5687128)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "11739749;15592455;17114649;17546647;18034455;20181826;21183079;21750661;23806337;25605945;30084848;33300544;34428180;37508490;37686339;38695862;39208794;9804986", "class_list": "", "function": "Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7. Publication Status: Online-Only, [RefSeq, PubMed]; Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function. Publication Status: Online-Only, [RefSeq, PubMed]; Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0099186 structural constituent of postsynapse", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097227 sperm annulus;GO:0032156 septin cytoskeleton;GO:0005940 septin ring;GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007010 cytoskeleton organization;GO:0048668 collateral sprouting;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O55131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JL1-1", "uniprot_id": [ { "id": "SPEF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JL1", "type": "external" } ], "mass": 26839.0, "length": 234, "protein_name": "Sperm flagella and cilia-associated protein 1", "gene_name": "Spef1", "organism": "Mouse", "refseq_name": "sperm flagellar protein 1", "refseq_ac": [ { "id": "NP_081917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081917", "type": "external" } ], "gene_names_uniprotkb": "Spef1; Clamp", "gene_names_refseq": "4931426K16Rik; Clamp; Spef1", "protein_names_uniprotkb": "Sperm flagella and cilia-associated protein 1; Calponin-homology and microtubule-associated protein", "protein_names_refseq": "calponin-homology and microtubule-associated protein; sperm flagellar protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70997)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15979255;16206169;21750661;30535028", "class_list": "", "function": "A.k.a. Spef1 (sperm flagella) and CLAMP (CaLponin-homology And Microtubule associated Protein) CLAMP/Spef1 expression also in brain, lung, and inner ear MT association of CLAMP requires the CH domain, which has highest similarity with EB family proteins Erratum:[Cell Motil Cytoskeleton. 2005 Dec;62(4):259], [RefSeq, PubMed]; Demonstrate a specific pattern of Spef1 localisation in the seminiferous epithelium of adult mouse testis, [RefSeq, PubMed]; Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (PubMed:16206169). Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (PubMed:30535028). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANS9;Q543S5;Q9D4J8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0016323 basolateral plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:1904158 axonemal central apparatus assembly;GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99JL1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97364-1", "uniprot_id": [ { "id": "SPS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97364", "type": "external" } ], "mass": 47834.0, "length": 452, "protein_name": "Selenide, water dikinase 2", "gene_name": "Sephs2", "organism": "Mouse", "refseq_name": "selenide, water dikinase 2", "refseq_ac": [ { "id": "NP_033292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033292", "type": "external" } ], "gene_names_uniprotkb": "Sephs2; Sps2", "gene_names_refseq": "Sephs2; Sps2; Ysg3", "protein_names_uniprotkb": "Selenide, water dikinase 2; 2.7.9.3; Selenium donor protein 2; Selenophosphate synthase 2", "protein_names_refseq": "selenide, water dikinase 2; selenium donor protein 2; selenophosphate synthase 2; the SelD gene product", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (mmu:20768); (R-MMU-2408557)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10515607;17194211;17346238;21183079;30084848;31219806;34428180;7588067;8986768", "class_list": "", "function": "Selenophosphate synthase that generates the selenium donor for selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP., [UniProtKB, PubMed, PubMed, PubMed]; These in vivo studies indicate that SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals., [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGI4;Q80ZY9", "ec_number_list": [ { "id": "2.7.9.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3", "type": "external" } ], "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process;GO:0001887 selenium compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97364-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTK8-1", "uniprot_id": [ { "id": "SPO11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTK8", "type": "external" } ], "mass": 44570.0, "length": 396, "protein_name": "Meiotic recombination protein SPO11", "gene_name": "Spo11", "organism": "Mouse", "refseq_name": "meiotic recombination protein SPO11 isoform c", "refseq_ac": [ { "id": "NP_001077428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077428", "type": "external" } ], "gene_names_uniprotkb": "Spo11", "gene_names_refseq": "Spo11a; Spo11b; Spo11", "protein_names_uniprotkb": "Meiotic recombination protein SPO11; 5.6.2.2", "protein_names_refseq": "SPO11 meiotic protein covalently bound to DSB homolog; meiotic recombination protein SPO11 isoform c; meiotic recombination protein SPO11; sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)", "tax_id": 10090, "disease": "", "pathway": " (mmu:26972)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10534401;10534402;10622720;10855504;11106738;11106739;21330546;22346761;26917764;39972125;39972129;39972130", "class_list": "", "function": "DNA endonuclease, which specifically mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:39972125, PubMed:39972129, PubMed:39972130). SPO11 covalently attaches itself to the 5' DNA strand during DSB formation and each strand is cleaved by a composite active site assembled at the interface of two SPO11 monomers, with the two cleavages staggered to produce a two-nucleotide 5' overhang (PubMed:39972125, PubMed:39972129, PubMed:39972130). SPO11 cleavage site selection is driven by a mild sequence bias and a preference for bendable and underwound DNA (PubMed:39972125, PubMed:39972129, PubMed:39972130). Together with TOP6BL, promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed:26917764). Required for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (PubMed:22346761)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; In contrast to isoform 1, does not mediate DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIH6;Q9QUK2;Q9QY57;Q9QZS1", "ec_number_list": [ { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000228 nuclear chromosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007286 spermatid development;GO:0001541 ovarian follicle development;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WTK8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BL97-1", "uniprot_id": [ { "id": "SRSF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BL97", "type": "external" } ], "mass": 30818.0, "length": 267, "protein_name": "Serine/arginine-rich splicing factor 7", "gene_name": "Srsf7", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 7 isoform 2", "refseq_ac": [ { "id": "NP_001182414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182414", "type": "external" } ], "gene_names_uniprotkb": "Srsf7; Sfrs7", "gene_names_refseq": "35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7; Srsf7", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 7; Splicing factor, arginine/serine-rich 7", "protein_names_refseq": "serine/arginine-rich splicing factor 7 isoform 2; serine/arginine-rich splicing factor 7; splicing factor, arginine/serine-rich 7", "tax_id": 10090, "disease": "clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:225027); (R-MMU-159236); (R-MMU-72163); (R-MMU-72165); (R-MMU-72187); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "16249178;21183079;21750661;23806337;29799838;31219806;33706811", "class_list": "", "function": "9G8 binds to an element in exon 3 and strongly enhances the excision of GnRH intron A in the presence of minimal amount of other nuclear components, [RefSeq, PubMed]; Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific (By similarity)., [UniProtKB, UniProtKB]; SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple protein-coding and non-protein-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2022]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMC6;Q8BUR2;Q8R2N4;Q8R3E9;Q91YS1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003676 nucleic acid binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:1990830 cellular response to leukemia inhibitory factor;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BL97-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ91-1", "uniprot_id": [ { "id": "SRFB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ91", "type": "external" } ], "mass": 48746.0, "length": 441, "protein_name": "Serum response factor-binding protein 1", "gene_name": "Srfbp1", "organism": "Mouse", "refseq_name": "serum response factor-binding protein 1", "refseq_ac": [ { "id": "NP_080316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080316", "type": "external" } ], "gene_names_uniprotkb": "Srfbp1", "gene_names_refseq": "2810036K01Rik; Srfbp1; p49/STRAP", "protein_names_uniprotkb": "Serum response factor-binding protein 1; SRF-dependent transcription regulation-associated protein; p49/STRAP", "protein_names_refseq": "SRF-dependent transcription regulation associated protein; serum response factor-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67222)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15492011;16647043;16782067;21750661;25183317;27337995;30779550", "class_list": "", "function": "49-kDa protein (p49/STRAP) specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4., [RefSeq, PubMed]; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells., [UniProtKB, PubMed, PubMed]; Overexpression of p49/STRAP reduced actin content in cultured cells and resulted in smaller cell size versus control cells. Publication Status: Online-Only, [RefSeq, PubMed]; P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells. The increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence., [RefSeq, PubMed]; P49/STRAP may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGY0;Q3UMK2;Q3UR20;Q8R3W6;Q9CRL0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0030686 90S preribosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CZ91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERG2-1", "uniprot_id": [ { "id": "STRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERG2", "type": "external" } ], "mass": 87150.0, "length": 796, "protein_name": "Striatin-3", "gene_name": "Strn3", "organism": "Mouse", "refseq_name": "striatin-3 isoform 1", "refseq_ac": [ { "id": "NP_443205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443205", "type": "external" } ], "gene_names_uniprotkb": "Strn3; Gs2na; Sg2na", "gene_names_refseq": "Gs2na; SG2NA; Strn3", "protein_names_uniprotkb": "Striatin-3; Cell cycle autoantigen SG2NA; S/G2 antigen", "protein_names_refseq": "cell cycle autoantigen SG2NA; nuclear autoantigen; s/G2 antigen; striatin-3 35 kDa; striatin-3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:94186)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10748158;18571342;19144319;21183079;25035075;31219806;34428180;36210013;37624915", "class_list": "", "function": "Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB]; Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia., [RefSeq, PubMed]; SG2NA associates with the antioxidant protein DJ-1 and the survival kinase Akt resulting in resistance to apoptosis induced by oxidative stress., [RefSeq, PubMed]; Taken together, splicing variation of SG2NA might have some critical roles in differentiation and maturation in metazoan cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0032355 response to estradiol;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ERG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5KM66-1", "uniprot_id": [ { "id": "SYCE3_MOUSE", "url": "https://www.uniprot.org/uniprot/B5KM66", "type": "external" } ], "mass": 10467.0, "length": 88, "protein_name": "Synaptonemal complex central element protein 3", "gene_name": "Syce3", "organism": "Mouse", "refseq_name": "synaptonemal complex central element protein 3", "refseq_ac": [ { "id": "NP_001156352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156352", "type": "external" } ], "gene_names_uniprotkb": "Syce3; Tseg2", "gene_names_refseq": "1700007E06Rik; Syce3; TSEG-2; TSEG2", "protein_names_uniprotkb": "Synaptonemal complex central element protein 3; TSEG-2; Testis-specific expressed protein 2", "protein_names_refseq": "synaptonemal complex central element protein 3; testis-specific expressed protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75459)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17660561;19323366;20407872;21637789;25394919;30949703;31437213;36635604", "class_list": "", "function": "A novel mouse testis specific gene TSEG-2 was successfully cloned, which could be down-regulated by cryptorchidism-inducible 17-beta estradiol. [TSEG-2], [RefSeq, PubMed]; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:21637789, PubMed:36635604). Required for the assembly of the central element of the synaptonemal complex during meiosis, via remodeling of SYCP1 lattice structures and promoting recruitment of SYCE2-TEX12 and SYCE1-SIX60S1 complexes (By similarity). Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes (PubMed:21637789). Chromosome loading appears to require SYCP1 (PubMed:21637789). Required for fertility and normal testis development (PubMed:21637789, PubMed:36635604). May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism (PubMed:20407872)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; SCRE interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3); the function of SCRE is to reinforce the integrity of the central elements, thereby stabilizing the SC and ensuring meiotic cell cycle progression, [RefSeq, PubMed]; SYCE3 is required for male and female fertility., [RefSeq, PubMed]; Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3., [RefSeq, PubMed]; TSEG-2 may participate in the apoptosis of spermatogenic cells and the pathogenesis of cryptorchidism., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division;GO:0007130 synaptonemal complex assembly;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B5KM66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52633-1", "uniprot_id": [ { "id": "STAT6_MOUSE", "url": "https://www.uniprot.org/uniprot/P52633", "type": "external" } ], "mass": 93497.0, "length": 837, "protein_name": "Signal transducer and transcription activator 6", "gene_name": "Stat6", "organism": "Mouse", "refseq_name": "signal transducer and transcription activator 6", "refseq_ac": [ { "id": "NP_033310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033310", "type": "external" } ], "gene_names_uniprotkb": "Stat6", "gene_names_refseq": "Stat6", "protein_names_uniprotkb": "Signal transducer and transcription activator 6", "protein_names_refseq": "signal transducer and transcription activator 6", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); lipoid nephrosis (Disease Ontology:DOID:10966); urinary schistosomiasis (Disease Ontology:DOID:1394); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841); gastric adenocarcinoma (Disease Ontology:DOID:3717); myocarditis (Disease Ontology:DOID:820); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:20852); (R-MMU-186763); (R-MMU-3249367); (R-MMU-6785807)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "16547273;17210636;19799897;21750661;22000020;23383189;24508458;27671227;27795451;29739850;29771943;30172259;30242286;31219806;31363052;32082309;34289986;34428180;35385697;35820727;36057627;38503016;39627609;7760829", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2F1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0002296 T-helper 1 cell lineage commitment;GO:0060443 mammary gland morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P52633-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZV4-1", "uniprot_id": [ { "id": "ST32C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZV4", "type": "external" } ], "mass": 55263.0, "length": 488, "protein_name": "Serine/threonine-protein kinase 32C", "gene_name": "Stk32c", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 32C isoform 2", "refseq_ac": [ { "id": "NP_001156012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156012", "type": "external" } ], "gene_names_uniprotkb": "Stk32c; MNCb-1563; Pkek", "gene_names_refseq": "PKE; Pkek; Stk32c; YANK3", "protein_names_uniprotkb": "Serine/threonine-protein kinase 32C; 2.7.11.1", "protein_names_refseq": "PKE protein kinase; serine/threonine-protein kinase 32C isoform 2; serine/threonine-protein kinase 32C", "tax_id": 10090, "disease": "", "pathway": " (mmu:57740)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJG4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1B0-1", "uniprot_id": [ { "id": "STAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1B0", "type": "external" } ], "mass": 44793.0, "length": 408, "protein_name": "SH3 and cysteine-rich domain-containing protein 2", "gene_name": "Stac2", "organism": "Mouse", "refseq_name": "SH3 and cysteine-rich domain-containing protein 2", "refseq_ac": [ { "id": "NP_666140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666140", "type": "external" } ], "gene_names_uniprotkb": "Stac2", "gene_names_refseq": "24b2/STAC2; 24b2; Stac2", "protein_names_uniprotkb": "SH3 and cysteine-rich domain-containing protein 2; 24b2/STAC2; Src homology 3 and cysteine-rich domain-containing protein 2", "protein_names_refseq": "SH3 and cysteine-rich domain-containing protein 2; SRC homology 3 and cysteine-rich domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217154)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;20736085;21183079;21750661;23818578;25548159;28112192;29348675;29363593;29467163", "class_list": "", "function": "Found STAC1 and STAC2 expressed in mutually exclusive fashion in adult DRG neurons; STAC1 marks peptidergic nociceptive neurons; STAC2 is expressed in subset of nonpeptidergic nociceptors, all trkB+ neurons and a subpopulation of proprioceptive neurons, [RefSeq, PubMed]; Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). Negative regulator of osteoclastogenesis. Following TNFSF11/RANKL stimulation, interacts with TNFRSF11A/RANK and interferes with the formation of the TNFRSF11A signaling complex, leading to the suppression of TNFSF11-initiated NF-kappa-B and MAPK signaling pathways. Impairs TNFSF11-induced, BTK/TEC-catalyzed PLCG2 phosphorylation and activation (PubMed:29348675)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; STAC2 physically interacts with RANK and inhibits the formation of the RANK signaling complex, which contains Grb-2-associated binder 2 (Gab2) and phospholipase Cgamma2 (PLCgamma2), thus leading to the suppression of RANK-mediated NF-kappaB and MAPK activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BV93;Q8K2U4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045121 membrane raft;GO:0042383 sarcolemma;GO:0009898 cytoplasmic side of plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0045671 negative regulation of osteoclast differentiation;GO:1901387 positive regulation of voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R1B0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBF8-1", "uniprot_id": [ { "id": "STUM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBF8", "type": "external" } ], "mass": 15005.0, "length": 141, "protein_name": "Protein stum homolog", "gene_name": "Stum", "organism": "Mouse", "refseq_name": "protein stum homolog", "refseq_ac": [ { "id": "NP_001074696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074696", "type": "external" } ], "gene_names_uniprotkb": "Stum", "gene_names_refseq": "6330403A02Rik; Gm10001; Stum", "protein_names_uniprotkb": "Protein stum homolog", "protein_names_refseq": "protein stum homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381310)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;24626929;27802388", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VBF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWF0-1", "uniprot_id": [ { "id": "SSDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWF0", "type": "external" } ], "mass": 55968.0, "length": 523, "protein_name": "Succinate-semialdehyde dehydrogenase, mitochondrial", "gene_name": "Aldh5a1", "organism": "Mouse", "refseq_name": "succinate-semialdehyde dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_766120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766120", "type": "external" } ], "gene_names_uniprotkb": "Aldh5a1", "gene_names_refseq": "6330403E24Rik; Ahd-1; Ahd1; Aldh5a1; D630032B01Rik; SSADH; Ssdh1", "protein_names_uniprotkb": "Succinate-semialdehyde dehydrogenase, mitochondrial; 1.2.1.24; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase", "protein_names_refseq": "NAD(+)-dependent succinic semialdehyde dehydrogenase; aldehyde dehydrogenase 1, mitochondrial; aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; succinate-semialdehyde dehydrogenase, mitochondrial precursor; succinate-semialdehyde dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "succinic semialdehyde dehydrogenase deficiency (Disease Ontology:DOID:0060175); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:214579); (R-MMU-916853)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;23576753;23806337;29053743;31032972;36288343;37453647;37507081;40684658", "class_list": "", "function": "Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)., [UniProtKB]; Maternal glutamine supplementation in murine succinic semialdehyde dehydrogenase deficiency, a disorder of gamma-aminobutyric acid metabolism., [RefSeq, PubMed]; NSC model of SSADHD will be valuable in providing a first-tier screen for centrally-acting therapeutics and prioritizing therapeutic concepts of preclinical animal studies applicable to SSADHD Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SZW1", "ec_number_list": [ { "id": "1.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0031406 carboxylic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006536 glutamate metabolic process;GO:0007417 central nervous system development;GO:0009791 post-embryonic development;GO:0009448 gamma-aminobutyric acid metabolic process;GO:0006105 succinate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BWF0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04202-1", "uniprot_id": [ { "id": "TGFB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P04202", "type": "external" } ], "mass": 44310.0, "length": 390, "protein_name": "Transforming growth factor beta-1 proprotein", "gene_name": "Tgfb1", "organism": "Mouse", "refseq_name": "transforming growth factor beta-1 proprotein preproprotein", "refseq_ac": [ { "id": "NP_035707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035707", "type": "external" } ], "gene_names_uniprotkb": "Tgfb1", "gene_names_refseq": "TGF-beta1; TGFbeta1; Tgfb-1; Tgfb1; Tgfb", "protein_names_uniprotkb": "Transforming growth factor beta-1 proprotein", "protein_names_refseq": "transforming growth factor beta-1 proprotein preproprotein; transforming growth factor beta-1 proprotein", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); chorioamnionitis (Disease Ontology:DOID:0050697); atrial fibrillation (Disease Ontology:DOID:0060224); Camurati-Engelmann disease 1 (Disease Ontology:DOID:0061229); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); traumatic brain injury (Disease Ontology:DOID:0081292); prostate cancer (Disease Ontology:DOID:10283); berylliosis (Disease Ontology:DOID:10322); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); anogenital venereal wart (Disease Ontology:DOID:11168); chlamydia (Disease Ontology:DOID:11263); heart disease (Disease Ontology:DOID:114); osteoporosis (Disease Ontology:DOID:11476); familial hyperlipidemia (Disease Ontology:DOID:1168); factor VIII deficiency (Disease Ontology:DOID:12134); vitiligo (Disease Ontology:DOID:12306); aplastic anemia (Disease Ontology:DOID:12449); urethral obstruction (Disease Ontology:DOID:12577); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); pulmonary sarcoidosis (Disease Ontology:DOID:13406); biliary atresia (Disease Ontology:DOID:13608); eosinophilic esophagitis (Disease Ontology:DOID:13922); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); cystic fibrosis (Disease Ontology:DOID:1485); colon carcinoma (Disease Ontology:DOID:1520); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); osteochondrodysplasia (Disease Ontology:DOID:2256); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tracheal stenosis (Disease Ontology:DOID:3227); atopic dermatitis (Disease Ontology:DOID:3310); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); insulinoma (Disease Ontology:DOID:3892); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); cholangiocarcinoma (Disease Ontology:DOID:4947); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); oral submucous fibrosis (Disease Ontology:DOID:5773); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); localized scleroderma (Disease Ontology:DOID:8472); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); actinic keratosis (Disease Ontology:DOID:8866); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21803); (R-MMU-114608); (R-MMU-2129379); (R-MMU-2173788); (R-MMU-2173789); (R-MMU-2173791); (R-MMU-3000170); (R-MMU-8941855); (R-MMU-8941858); (R-MMU-8951936); (R-MMU-9839389)", "pathway_count": 11, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10025398;14973287;14985127;15206957;16075062;18368049;19745830;21750661;21880733;22781750;22995554;26740625;26858265;29909984;3007454;33548622;34428180;36600556;8522200", "class_list": "", "function": "Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (PubMed:22781750, PubMed:29909984). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus (PubMed:29909984). TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1 (By similarity) (PubMed:10025398). Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules' (PubMed:29909984). Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (PubMed:22781750). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (PubMed:18368049). At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development (PubMed:18368049). At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (By similarity). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Positively regulates odontoblastic differentiation in dental papilla cells, via promotion of IPO7-mediated translocation of phosphorylated SMAD2 to the nucleus and subsequent transcription of target genes (PubMed:33548622). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix (PubMed:29909984). Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1 (PubMed:29909984). Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (PubMed:29909984). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs) (By similarity). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1 (PubMed:10025398)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. [provided by RefSeq, Aug 2016]., [RefSeq]; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 79, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060762 regulation of branching involved in mammary gland duct morphogenesis;GO:0030316 osteoclast differentiation;GO:0016202 regulation of striated muscle tissue development;GO:0060364 frontal suture morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P04202-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSZ5-1", "uniprot_id": [ { "id": "TENS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSZ5", "type": "external" } ], "mass": 155589.0, "length": 1440, "protein_name": "Tensin-3", "gene_name": "Tns3", "organism": "Mouse", "refseq_name": "tensin-3", "refseq_ac": [ { "id": "NP_001077056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077056", "type": "external" } ], "gene_names_uniprotkb": "Tns3; Tens1", "gene_names_refseq": "F830010I22Rik; TEM6; Tens1; Tns3", "protein_names_uniprotkb": "Tensin-3; 3.1.3.-; Tensin-like SH2 domain-containing protein 1", "protein_names_refseq": "tensin-3; tensin-like SH2 domain containing 1; tensin-like SH2 domain-containing protein 1; tumor endothelial marker 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:319939); (R-MMU-8875513)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;15733665;17242355;19144319;19732724;21183079;21750661;25153642;25428506;26495903;27505886;28528544;30084848;34203471;34418053;34428180;35687021;35984892;36210013;38109544", "class_list": "", "function": "Dock5 and tensin 3 cooperate for osteoclast activity, to ensure the correct organization of podosomes., [RefSeq, PubMed]; Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination., [RefSeq, PubMed]; May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (By similarity). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (By similarity). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (PubMed:27505886). Enhances RHOA activation in the presence of DLC1 (By similarity). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (By similarity). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (By similarity). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results indicate that tensin3 is essential for normal development and functions of the small intestine, lung, and bone [tensin3]., [RefSeq, PubMed]; Tns3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ54;Q8BJA7", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0004721 phosphoprotein phosphatase activity;GO:0005091 guanyl-nucleotide exchange factor adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0002102 podosome;GO:0042995 cell projection", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0048286 lung alveolus development;GO:0045453 bone resorption;GO:0035022 positive regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q5SSZ5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97430-1", "uniprot_id": [ { "id": "SLPI_MOUSE", "url": "https://www.uniprot.org/uniprot/P97430", "type": "external" } ], "mass": 14308.0, "length": 131, "protein_name": "Antileukoproteinase", "gene_name": "Slpi", "organism": "Mouse", "refseq_name": "antileukoproteinase isoform 1 precursor", "refseq_ac": [ { "id": "NP_035544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035544", "type": "external" } ], "gene_names_uniprotkb": "Slpi", "gene_names_refseq": "ALP; Slpi", "protein_names_uniprotkb": "Antileukoproteinase; ALP; Secretory leukocyte protease inhibitor", "protein_names_refseq": "antileukoproteinase isoform 1 precursor; antileukoproteinase; secretory leukocyte protease inhibitor", "tax_id": 10090, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:20568); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11017147;12526812;12615907;18322212;21750661;25030421;34379860;35984892;38270443;9039268;9126337;9351627", "class_list": "", "function": "Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:9126337). Modulates the innate immune response after bacterial infection (PubMed:12615907). Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major (PubMed:25030421). Down-regulates responses to bacterial lipopolysaccharide (LPS) (PubMed:12615907, PubMed:25030421, PubMed:9039268). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:11017147, PubMed:12615907). Has antimicrobial activity against mycobacteria, but not against salmonella (PubMed:18322212). Contributes to normal resistance against infection by M.tuberculosis (PubMed:18322212). Required for normal resistance to L.major (PubMed:25030421). Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (PubMed:11017147, PubMed:25030421). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier., [RefSeq, PubMed]; Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09081;O09082", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0019899 enzyme binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005576 extracellular region", "go_biological_process": "GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97430-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61014-1", "uniprot_id": [ { "id": "PPLA_MOUSE", "url": "https://www.uniprot.org/uniprot/P61014", "type": "external" } ], "mass": 6095.0, "length": 52, "protein_name": "Phospholamban", "gene_name": "Pln", "organism": "Mouse", "refseq_name": "phospholamban", "refseq_ac": [ { "id": "NP_001135399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135399", "type": "external" } ], "gene_names_uniprotkb": "Pln", "gene_names_refseq": "Plb; Pln", "protein_names_uniprotkb": "Phospholamban; PLB", "protein_names_refseq": "cardiac phospholamban; phospholamban", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 18 (Disease Ontology:DOID:0110324); dilated cardiomyopathy 1P (Disease Ontology:DOID:0110439); heart disease (Disease Ontology:DOID:114); centronuclear myopathy (Disease Ontology:DOID:14717); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18821); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 37, "publication_id_list": "10809743;10988285;11854448;12479233;12969887;1394867;15276030;16516179;16582020;16648892;17950750;18007024;18400986;19696029;20890288;20942811;21183079;22874425;22971924;23986715;24052497;24427143;24892712;26644582;26816378;27923914;29674140;30733280;31449798;31685870;32210830;32716920;33525071;34502355;36053712;36288343;38493225", "class_list": "", "function": "Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:22971924, PubMed:27923914, PubMed:31449798). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (PubMed:22971924, PubMed:26816378). Also inhibits the activity of ATP2A3/SERCA3 (PubMed:27923914). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (PubMed:30733280). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (PubMed:38493225)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20006;Q3UQ75", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0042030 ATPase inhibitor activity;GO:0141110 transporter inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031982 vesicle;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0086092 regulation of the force of heart contraction by cardiac conduction;GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P61014-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571I4-1", "uniprot_id": [ { "id": "PRAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571I4", "type": "external" } ], "mass": 147945.0, "length": 1373, "protein_name": "Inactive tyrosine-protein kinase PRAG1", "gene_name": "Prag1", "organism": "Mouse", "refseq_name": "inactive tyrosine-protein kinase PRAG1", "refseq_ac": [ { "id": "NP_766499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766499", "type": "external" } ], "gene_names_uniprotkb": "Prag1; D8Ertd82e; Nack; Sgk223", "gene_names_refseq": "9830148H23; D8Ertd82e; NACK; Prag1; Sgk223; mFLJ00269", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase PRAG1; Notch activation complex kinase; PEAK1-related kinase-activating pseudokinase 1; Sugen kinase 223; Tyrosine-protein kinase SgK223", "protein_names_refseq": "inactive tyrosine-protein kinase PRAG1; notch activation complex kinase; pragmin; sugen kinase 223; tyrosine-protein kinase PRAG1; tyrosine-protein kinase SgK223", "tax_id": 10090, "disease": "", "pathway": " (mmu:244418); (R-MMU-9696270)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15289607;15592455;19144319;22645316;25038227;26495903;34428180", "class_list": "", "function": "Also known as SgK223, a member of the NKF3 family of protein kinases predicted to be catalytically inactive., [RefSeq, PubMed]; Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (PubMed:25038227)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QLH9;Q8CB68", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "GO:0016477 cell migration;GO:2000145 regulation of cell motility;GO:0010977 negative regulation of neuron projection development;GO:0035025 positive regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q571I4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMB3-1", "uniprot_id": [ { "id": "PPR3C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMB3", "type": "external" } ], "mass": 36460.0, "length": 317, "protein_name": "Protein phosphatase 1 regulatory subunit 3C", "gene_name": "Ppp1r3c", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 3C", "refseq_ac": [ { "id": "NP_058550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058550", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3c; Ppp1r5", "gene_names_refseq": "PTG; Ppp1r3c; Ppp1r5", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3C; PP1 subunit R5; PTG; Protein phosphatase 1 regulatory subunit 5; Protein targeting to glycogen", "protein_names_refseq": "PP1 subunit R5; protein phosphatase 1 binding protein PTG; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein phosphatase 1, regulatory (inhibitor) subunit 5; protein targeting to glicogen; protein targeting to glycogen", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:53412); (R-MMU-3322077)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10683377;10862764;10938087;10998419;12727934;12805359;15322104;16354703;30059200;30084848;34428180;9045612;9242697;9756875", "class_list": "glycogene", "function": "Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PTG overexpression in 3T3-L1 adipocytes discretely stimulates PP1 activity against glycogen synthase and phosphorylase, resulting in a marked and specific increase in glucose uptake and storage as glycogen., [RefSeq, PubMed]; These data indicate that disruption of PTG expression resulted in the uncoupling of PP1 activity from glycogen metabolizing enzymes, the enhancement of glycogenolysis, and a dramatic decrease in cellular glycogen levels., [RefSeq, PubMed]; These data suggest that PTG plays a critical role in glycogen synthesis and is necessary to maintain the appropriate metabolic balance for the partitioning of fuel substrates between glycogen and lipid., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08541;Q8BJW8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005829 cytosol;GO:0042587 glycogen granule", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process;GO:0006605 protein targeting;GO:0005978 glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TMB3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2C9-1", "uniprot_id": [ { "id": "HACD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2C9", "type": "external" } ], "mass": 43131.0, "length": 362, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3", "gene_name": "Hacd3", "organism": "Mouse", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3", "refseq_ac": [ { "id": "NP_067320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067320", "type": "external" } ], "gene_names_uniprotkb": "Hacd3; Ptplad1", "gene_names_refseq": "4930523M17Rik; B-ind1; Hacd3; Hcad3; Hspc121; Ptplad1", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; 3-hydroxyacyl-CoA dehydratase 3; 4.2.1.134; B-ind1; Butyrate-induced protein 1; HACD3; Protein-tyrosine phosphatase-like A domain-containing protein 1", "protein_names_refseq": "butyrate-induced protein 1; butyrate-induced transcript 1; protein tyrosine phosphatase-like A domain containing 1; protein tyrosine phosphatase-like protein PTPLAD1; protein-tyrosine phosphatase-like A domain-containing protein 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:57874); (R-MMU-75876)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10747961;15345747;17114649;17208939;17242355;18630941;19144319;21183079;25428506;33300544;34428180;35820727;37453647", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09003;Q6PGH3;Q8BGM8", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "4.2.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107", "type": "external" }, { "id": "4.2.1.119", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046726 positive regulation by virus of viral protein levels in host cell;GO:1902532 negative regulation of intracellular signal transduction;GO:0007254 JNK cascade;GO:0030148 sphingolipid biosynthetic process;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8K2C9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERE3-1", "uniprot_id": [ { "id": "SGK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERE3", "type": "external" } ], "mass": 57145.0, "length": 496, "protein_name": "Serine/threonine-protein kinase Sgk3", "gene_name": "Sgk3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Sgk3", "refseq_ac": [ { "id": "NP_001032848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032848", "type": "external" } ], "gene_names_uniprotkb": "Sgk3; Cisk; Sgkl", "gene_names_refseq": "2510015P22Rik; A330005P07Rik; Cisk; Sgk3; fy; fz", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk3; 2.7.11.1; Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like", "protein_names_refseq": "cytokine-independent survival kinase; serine/threonine-protein kinase Sgk3", "tax_id": 10090, "disease": "", "pathway": " (mmu:170755); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11050396;11514587;15774535;15774536;18299400;19144319;21113728;21183079;21451460;21750661;21865597;22872234;26495903;30084848;30779550;34428180;36269185;38169564;39158709", "class_list": "", "function": "MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells., [RefSeq, PubMed]; SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAY2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9ERE3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VP2-1", "uniprot_id": [ { "id": "SPAT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VP2", "type": "external" } ], "mass": 65655.0, "length": 582, "protein_name": "Spermatogenesis-associated protein 7 homolog", "gene_name": "Spata7", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 7 homolog isoform 1", "refseq_ac": [ { "id": "NP_849245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849245", "type": "external" } ], "gene_names_uniprotkb": "Spata7", "gene_names_refseq": "B230306G18Rik; HSD3; Spata7", "protein_names_uniprotkb": "Spermatogenesis-associated protein 7 homolog", "protein_names_refseq": "spermatogenesis-associated protein 7 homolog isoform 1; spermatogenesis-associated protein 7 homolog", "tax_id": 10090, "disease": "Leber congenital amaurosis 3 (Disease Ontology:DOID:0110331)", "pathway": " (mmu:104871)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19268277;25398945;29100828;29899041;33109704;35368022", "class_list": "", "function": "Involved in the maintenance of both rod and cone photoreceptor cells (PubMed:25398945, PubMed:29100828, PubMed:29899041). Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone (PubMed:25398945, PubMed:29100828, PubMed:29899041). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (PubMed:25398945, PubMed:29899041)., [UniProtKB, PubMed, PubMed, PubMed]; Spata7 is expressed in the mature mouse retina. Erratum:[Am J Hum Genet. 2010 Feb;86(2):293. Abboud, Emad B [added]; Al-Rajhi, Ali A [added]], [RefSeq, PubMed]; Spata7 is required for maintenance of the retinal connecting cilium. Publication Status: Online-Only, [RefSeq, PubMed]; The absence of Spata7 results in the mislocalization of DCC proteins without affecting the proximal connecting cilium (PCC) protein complexes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK23", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0032391 photoreceptor connecting cilium;GO:0097225 sperm midpiece", "go_biological_process": "GO:1903621 protein localization to photoreceptor connecting cilium;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0000226 microtubule cytoskeleton organization;GO:1903546 protein localization to photoreceptor outer segment", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80VP2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C804-1", "uniprot_id": [ { "id": "SPICE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C804", "type": "external" } ], "mass": 95645.0, "length": 860, "protein_name": "Spindle and centriole-associated protein 1", "gene_name": "Spice1", "organism": "Mouse", "refseq_name": "spindle and centriole-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_653133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653133", "type": "external" } ], "gene_names_uniprotkb": "Spice1; Ccdc52; D16Ertd480e", "gene_names_refseq": "Ccdc52; D16Ertd480e; Spice1", "protein_names_uniprotkb": "Spindle and centriole-associated protein 1; Coiled-coil domain-containing protein 52", "protein_names_refseq": "coiled-coil domain containing 52; coiled-coil domain-containing protein 52; spindle and centriole-associated protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212514)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20360068;21183079;34428180", "class_list": "", "function": "Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3I7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0046599 regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C804-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIJ6-1", "uniprot_id": [ { "id": "SFPQ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIJ6", "type": "external" } ], "mass": 75442.0, "length": 699, "protein_name": "Splicing factor, proline- and glutamine-rich", "gene_name": "Sfpq", "organism": "Mouse", "refseq_name": "splicing factor, proline- and glutamine-rich", "refseq_ac": [ { "id": "NP_076092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076092", "type": "external" } ], "gene_names_uniprotkb": "Sfpq; Psf", "gene_names_refseq": "1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik; D4Ertd314e; Gm12940; PSF; REP1; Sfpq", "protein_names_uniprotkb": "Splicing factor, proline- and glutamine-rich; DNA-binding p52/p100 complex, 100 kDa subunit; PSF; PTB-associated-splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor", "protein_names_refseq": "DNA-binding p52/p100 complex, 100 kDa subunit; PTB-associated splicing factor; polypyrimidine tract-binding protein-associated-splicing factor; splicing factor, proline- and glutamine-rich", "tax_id": 10090, "disease": "", "pathway": " (mmu:71514); (R-MMU-8849468)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;11008015;11514619;12112008;15140795;17242355;19144721;21183079;21680841;21750661;22645316;22966205;23806337;24129315;25428506;25605945;28528544;29125738;31219806;32848054;33300544;34428180;34678516;34787639;34887587;35820727;36288343;37453647;39627609;40885482;40997131", "class_list": "", "function": "DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (By similarity). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (PubMed:21680841, PubMed:22966205). Required for the assembly of nuclear speckles (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Identified as a protein kinase Calpha-binding protein in the cell nucleus, [RefSeq, PubMed]; LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control RPE Cell Proliferation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2A7U6;Q9ERW2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0030425 dendrite", "go_biological_process": "GO:0098963 dendritic transport of messenger ribonucleoprotein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q8VIJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D495-1", "uniprot_id": [ { "id": "SYCE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D495", "type": "external" } ], "mass": 38205.0, "length": 329, "protein_name": "Synaptonemal complex central element protein 1", "gene_name": "Syce1", "organism": "Mouse", "refseq_name": "synaptonemal complex central element protein 1", "refseq_ac": [ { "id": "NP_001137237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137237", "type": "external" } ], "gene_names_uniprotkb": "Syce1", "gene_names_refseq": "4933406J07Rik; Syce1", "protein_names_uniprotkb": "Synaptonemal complex central element protein 1", "protein_names_refseq": "synaptonemal complex central element protein 1", "tax_id": 10090, "disease": "spermatogenic failure 15 (Disease Ontology:DOID:0070172); primary ovarian insufficiency 12 (Disease Ontology:DOID:0080869)", "pathway": " (mmu:74075)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15944401;16968740;17660561;19247432;21637789;21750661;27796301", "class_list": "", "function": "Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:15944401). Requires SYCP1 in order to be incorporated into the central element (PubMed:15944401, PubMed:16968740). May have a role in the synaptonemal complex assembly, stabilization and recombination (PubMed:15944401)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Mutation in the Syce1 results in disruption of synapsis. Erratum:[PLoS Genet. 2009 Apr;5(4). doi: 10.1371/annotation/50260271-aed9-4316-b09a-304591b0cba5. Hall, Emma [added]], [RefSeq, PubMed]; The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene expressed in female germline in addition to male germline., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0051301 cell division;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D495-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBZ9-1", "uniprot_id": [ { "id": "SYDE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBZ9", "type": "external" } ], "mass": 80496.0, "length": 737, "protein_name": "Rho GTPase-activating protein SYDE1", "gene_name": "Syde1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Syde1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho GTPase-activating protein SYDE1; Protein syd-1 homolog 1; Synapse defective protein 1 homolog 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71709); (R-MMU-9013148); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013409); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "21183079;21750661;27917469;31219806", "class_list": "", "function": "GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0044877 protein-containing complex binding;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0097060 synaptic membrane;GO:0098793 presynapse;GO:0044300 cerebellar mossy fiber", "go_biological_process": "GO:0007165 signal transduction;GO:0016477 cell migration;GO:0030036 actin cytoskeleton organization;GO:1901165 positive regulation of trophoblast cell migration;GO:0090630 activation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DBZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55821-1", "uniprot_id": [ { "id": "STMN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P55821", "type": "external" } ], "mass": 20828.0, "length": 179, "protein_name": "Stathmin-2", "gene_name": "Stmn2", "organism": "Mouse", "refseq_name": "stathmin-2", "refseq_ac": [ { "id": "NP_079561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079561", "type": "external" } ], "gene_names_uniprotkb": "Stmn2; Scg10; Scgn10; Stmb2", "gene_names_refseq": "SCG10; Scgn10; Stmb2; Stmn2", "protein_names_uniprotkb": "Stathmin-2; Protein SCG10; Superior cervical ganglion-10 protein", "protein_names_refseq": "stathmin-2; superior cervical ganglion-10 protein; superiorcervical ganglia, neural specific 10", "tax_id": 10090, "disease": "motor peripheral neuropathy (Disease Ontology:DOID:2477); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); neuropathy (Disease Ontology:DOID:870)", "pathway": " (mmu:20257); (R-MMU-9696273)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16618812;21183079;21297631;34428180;35820727;39152325;8288240", "class_list": "", "function": "HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-beta/Smad signaling pathway., [RefSeq, PubMed]; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031117 positive regulation of microtubule depolymerization;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P55821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGE4-1", "uniprot_id": [ { "id": "SUSD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGE4", "type": "external" } ], "mass": 31978.0, "length": 302, "protein_name": "Sushi domain-containing protein 6", "gene_name": "Susd6", "organism": "Mouse", "refseq_name": "sushi domain-containing protein 6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001229348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229348", "type": "external" } ], "gene_names_uniprotkb": "Susd6; Kiaa0247", "gene_names_refseq": "4933426M11Rik; Susd6; mKIAA0247", "protein_names_uniprotkb": "Sushi domain-containing protein 6; Drago", "protein_names_refseq": "drago; sushi domain-containing protein 6 isoform 1 precursor; sushi domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:217684)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24652652", "class_list": "", "function": "May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (By similarity). Plays a role in preventing tumor onset (PubMed:24652652)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZW2-1", "uniprot_id": [ { "id": "SWAHB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZW2", "type": "external" } ], "mass": 83542.0, "length": 760, "protein_name": "Ankyrin repeat domain-containing protein SOWAHB", "gene_name": "Sowahb", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein SOWAHB", "refseq_ac": [ { "id": "NP_780479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780479", "type": "external" } ], "gene_names_uniprotkb": "Sowahb; Ankrd56", "gene_names_refseq": "5730467H21Rik; Ankrd56; Sowahb", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein SOWAHB; Ankyrin repeat domain-containing protein 56; Protein sosondowah homolog B", "protein_names_refseq": "ankyrin repeat domain 56; ankyrin repeat domain-containing protein 56; ankyrin repeat domain-containing protein SOWAHB; protein sosondowah homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:78088)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZS7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BZW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0J6-1", "uniprot_id": [ { "id": "SWAHC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0J6", "type": "external" } ], "mass": 54938.0, "length": 512, "protein_name": "Ankyrin repeat domain-containing protein SOWAHC", "gene_name": "Sowahc", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein SOWAHC", "refseq_ac": [ { "id": "NP_766527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766527", "type": "external" } ], "gene_names_uniprotkb": "Sowahc; Ankrd57", "gene_names_refseq": "4921515A04Rik; 9430099J10Rik; Ankrd57; C820004L04Rik; Sowahc", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein SOWAHC; Ankyrin repeat domain-containing protein 57; Protein sosondowah homolog C", "protein_names_refseq": "ankyrin repeat domain 57; ankyrin repeat domain-containing protein 57; ankyrin repeat domain-containing protein SOWAHC; protein sosondowah homolog C", "tax_id": 10090, "disease": "", "pathway": " (mmu:268301); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9035034)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "19144319;21183079;24129315;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWN1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C0J6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70146-1", "uniprot_id": [ { "id": "TESK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70146", "type": "external" } ], "mass": 68052.0, "length": 627, "protein_name": "Dual specificity testis-specific protein kinase 1", "gene_name": "Tesk1", "organism": "Mouse", "refseq_name": "dual specificity testis-specific protein kinase 1", "refseq_ac": [ { "id": "NP_035701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035701", "type": "external" } ], "gene_names_uniprotkb": "Tesk1", "gene_names_refseq": "Tesk1", "protein_names_uniprotkb": "Dual specificity testis-specific protein kinase 1; 2.7.12.1; Testicular protein kinase 1", "protein_names_refseq": "dual specificity testis-specific protein kinase 1; testicular protein kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21754); (R-MMU-446388)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17974561;21750661;24129315;30115939;37828378;9469938", "class_list": "", "function": "Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (By similarity). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O70147;Q499W7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007283 spermatogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70146-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62915-1", "uniprot_id": [ { "id": "TF2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P62915", "type": "external" } ], "mass": 34819.0, "length": 316, "protein_name": "Transcription initiation factor IIB", "gene_name": "Gtf2b", "organism": "Mouse", "refseq_name": "transcription initiation factor IIB", "refseq_ac": [ { "id": "NP_663521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663521", "type": "external" } ], "gene_names_uniprotkb": "Gtf2b", "gene_names_refseq": "Gtf2b", "protein_names_uniprotkb": "Transcription initiation factor IIB; 2.3.1.48; General transcription factor TFIIB; RNA polymerase II alpha initiation factor", "protein_names_refseq": "RNA polymerase II alpha initiation factor; general transcription factor TFIIB; transcription initiation factor IIB", "tax_id": 10090, "disease": "", "pathway": " (mmu:229906); (R-MMU-674695); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "14612417;19393171;25398966;34428180", "class_list": "", "function": "By acutely targeting TFIIB, we were able to inhibit selectively the former set of genes and ameliorate pressure overload hypertrophy., [RefSeq, PubMed]; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription., [UniProtKB, UniProtKB]; Study suggest that components of the transcription machinery decreased in accordance with cell differentiation and that TFIIB is specifically and rapidly degraded by the ubiquitin-proteasome pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29053", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000793 condensed chromosome", "go_biological_process": "GO:0019083 viral transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006473 protein acetylation;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62915-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UNW5-1", "uniprot_id": [ { "id": "TF2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UNW5", "type": "external" } ], "mass": 54737.0, "length": 479, "protein_name": "Transcription factor CP2-like protein 1", "gene_name": "Tfcp2l1", "organism": "Mouse", "refseq_name": "transcription factor CP2-like protein 1", "refseq_ac": [ { "id": "NP_076244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076244", "type": "external" } ], "gene_names_uniprotkb": "Tfcp2l1; Crtr1; Tcfcp2l1", "gene_names_refseq": "1810030F05Rik; 4932442M07Rik; Cp2l1; Crtr-1; D930018N21Rik; LBP-9; Tcfcp2l1; Tfcp2l1", "protein_names_uniprotkb": "Transcription factor CP2-like protein 1; CP2-related transcriptional repressor 1; CRTR-1", "protein_names_refseq": "CP2-related transcriptional repressor 1; Tcfcp2-related transcriptional repressor 1; transcription factor CP2-like protein 1; transcription repressor CRTR-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:81879)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11073954;17079272;23942233;23942238;26321140;28577314;28982712;37119134;38418821", "class_list": "", "function": "Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1., [RefSeq, PubMed]; Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:23942233, PubMed:26321140). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling (PubMed:23942233, PubMed:23942238, PubMed:26321140). Required for normal duct development in the salivary gland and kidney (PubMed:17079272). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (PubMed:28577314). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1 (PubMed:28577314). Also regulates the expression of Jag1 and subsequent notch signaling in the collecting duct (PubMed:28577314). Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs (PubMed:28577314). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (PubMed:11073954). Modulates the placental expression of CYP11A1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AW3;Q99PF2", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UNW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGW0-1", "uniprot_id": [ { "id": "THMS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGW0", "type": "external" } ], "mass": 72780.0, "length": 636, "protein_name": "Protein THEMIS", "gene_name": "Themis", "organism": "Mouse", "refseq_name": "protein THEMIS isoform 2", "refseq_ac": [ { "id": "NP_001292592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292592", "type": "external" } ], "gene_names_uniprotkb": "Themis", "gene_names_refseq": "E430004N04Rik; Gasp; Spot; Themis; Tsepa; thylex", "protein_names_uniprotkb": "Protein THEMIS; Gasp; Grb2-associating protein; Protein thylex; Thymocyte-expressed molecule involved in selection", "protein_names_refseq": "grb2-associating protein; protein THEMIS isoform 2; protein THEMIS; signaling phosphoprotein specific for T cells; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; thymus lymphocyte exclusively expressed", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (mmu:210757)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19597497;19597498;19597499;19620281;19805304;21750661;22561606;36210013;37739454;38565808;38713628", "class_list": "", "function": "Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Study described a gene called Gasp that is critical for positive selection. GeneRIF: Gasp associates with Grb2 and is required for positive selection of thymocytes, [RefSeq, PubMed]; THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA., [RefSeq, PubMed]; Themis controls T cell activation, effector functions, and metabolism of peripheral CD8[+] T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation. Erratum:[Nat Immunol. 2010 Jan;11(1):97], [RefSeq, PubMed]; Themis had high expression in thymocytes between the pre-T cell antigen receptor and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes., [RefSeq, PubMed]; Themis plays a unique role in sustaining positive selection GeneRIF: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection Erratum:[Nat Immunol. 2010 Jan;11(1):97], [RefSeq, PubMed]; This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059Y0;Q3TEM0;Q3UU76;Q8BGP0;Q8C9S6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0043383 negative T cell selection;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0043368 positive T cell selection", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGW0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1S3-1", "uniprot_id": [ { "id": "UNC5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1S3", "type": "external" } ], "mass": 103739.0, "length": 945, "protein_name": "Netrin receptor UNC5B", "gene_name": "Unc5b", "organism": "Mouse", "refseq_name": "netrin receptor UNC5B isoform 1 precursor", "refseq_ac": [ { "id": "NP_084046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084046", "type": "external" } ], "gene_names_uniprotkb": "Unc5b; Unc5h2", "gene_names_refseq": "6330415E02Rik; A630020F16; D10Bwg0792e; Unc5b; Unc5h2", "protein_names_uniprotkb": "Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B", "protein_names_refseq": "netrin receptor UNC5B isoform 1 precursor; netrin receptor UNC5B; protein unc-5 homolog 2; protein unc-5 homolog B; unc5 homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:107449)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12351186;12799072;15510105;17139086;19492039;21673655;22405201;22645316;25374360", "class_list": "", "function": "Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as a netrin receptor that negatively regulates vascular branching during angiogenesis (PubMed:15510105). Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (PubMed:15510105). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 2, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 2, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 2, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4F2;Q6PFH0;Q80Y85;Q9D398", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0001525 angiogenesis;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K1S3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1110000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN6-1", "uniprot_id": [ { "id": "TRIM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESN6", "type": "external" } ], "mass": 81445.0, "length": 744, "protein_name": "Tripartite motif-containing protein 2", "gene_name": "Trim2", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001258654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258654", "type": "external" } ], "gene_names_uniprotkb": "Trim2; Kiaa0517; Narf", "gene_names_refseq": "Trim2; mKIAA0517; narf", "protein_names_uniprotkb": "Tripartite motif-containing protein 2; 2.3.2.27; E3 ubiquitin-protein ligase TRIM2; Neural activity-related RING finger protein; RING-type E3 ubiquitin transferase TRIM2", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2; neural activity-related ring finger protein; tripartite motif protein 2; tripartite motif protein TRIM2; tripartite motif-containing protein 2 isoform 1; tripartite motif-containing protein 2", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 2R (Disease Ontology:DOID:0110161); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:80890)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11331580;11432975;18687884;20796172;21183079;21478148;21750661;25428506;30084848;30726215;31219806;33300544;34428180;38542330", "class_list": "", "function": "TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM2 is an ubiquitin ligase and point to a mechanism regulating neurofilament light subunit metabolism through an ubiquitination pathway that, if deregulated, triggers neurodegeneration, [RefSeq, PubMed]; Trim2 has an important function in the regulation of axon outgrowth during development., [RefSeq, PubMed]; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits new world arenavirus infection independently of its ubiquitin ligase activity by decreasing virus internalization (PubMed:30726215)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHP5;Q5DU27;Q8C981", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9ESN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDW4-1", "uniprot_id": [ { "id": "UBE2W_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDW4", "type": "external" } ], "mass": 17345.0, "length": 151, "protein_name": "Ubiquitin-conjugating enzyme E2 W", "gene_name": "Ube2w", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 W isoform 1", "refseq_ac": [ { "id": "NP_080049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080049", "type": "external" } ], "gene_names_uniprotkb": "Ube2w", "gene_names_refseq": "6130401J04Rik; Ube2w", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 W; 2.3.2.23; 2.3.2.25; E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ubiquitin carrier protein W; Ubiquitin-protein ligase W", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; probable ubiquitin-conjugating enzyme E2 W; ubiquitin carrier protein W; ubiquitin-conjugating enzyme E2 W isoform 1; ubiquitin-protein ligase W", "tax_id": 10090, "disease": "", "pathway": " (mmu:66799); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21229326;21750661;21855799;28986324;31710394;34428180;35314916;38189387", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:21229326, PubMed:21855799). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3 (PubMed:21855799). After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination also occurs in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Expression levels of UBE2W in mouse testes were gradually elevated from 2 to 10 weeks, while were significantly deceased in the testes with hypospermatogenesis. When UBE2W expression was successfully down-regulated in spermatogenic cells, the rate of apoptosis was significantly increased and the P53/Bcl-2/caspase 6/caspase 9 signal pathways were activated., [RefSeq, PubMed]; Study shows the absence of ubiquitin conjugating enzyme Ube2W in HdhQ200 knock-in mice increases levels of soluble monomeric mutant huntingtin while reducing insoluble oligomeric species. This study sheds light on the potential function of the non-canonical ubiquitin-conjugating enzyme, Ube2W, in this polyQ neurodegenerative disease., [RefSeq, PubMed]; UBE2W Improves the Experimental Colitis by Inhibiting the NF-kappaB Signaling Pathway., [RefSeq, PubMed]; UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6., [RefSeq, PubMed]; [UBE2W overexpression promotes proliferation of intestinal mucosal cells in mice with chemically induced colitis]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVJ8;Q9D5H3", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031669 cellular response to nutrient levels;GO:0070979 protein K11-linked ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VDW4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15975-1", "uniprot_id": [ { "id": "UBP53_MOUSE", "url": "https://www.uniprot.org/uniprot/P15975", "type": "external" } ], "mass": 119255.0, "length": 1069, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 53", "gene_name": "Usp53", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 53 isoform 2", "refseq_ac": [ { "id": "NP_598618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598618", "type": "external" } ], "gene_names_uniprotkb": "Usp53; Phxr3", "gene_names_refseq": "Phxr3; Sp6; Usp53; mKIAA1350; mbo", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 53; 3.4.19.12; Per-hexamer repeat protein 3; Protein mambo; Ubiquitin-specific peptidase 53", "protein_names_refseq": "inactive ubiquitin carboxyl-terminal hydrolase 53; inactive ubiquitin-specific peptidase 53; per-hexamer repeat gene 3; per-hexamer repeat protein 3; protein mambo; ubiquitin carboxyl-terminal hydrolase 53 isoform 2; ubiquitin specific protease 53", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:99526)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;26609154;30250217;3267239;36726200", "class_list": "", "function": "A USP53 mutation is the cause of progressive hearing loss in the mambo mouse line., [RefSeq, PubMed]; Deubiquitinase that mediates 'Lys-63'-linked deubiquitination of tight junction proteins, such as MARVELD2 and LSR, and which is involved in the survival of auditory hair cells and hearing (By similarity). Specifically cleaves 'Lys-63'-linked polyubiquitin chains composed of at least 3 ubiquitin molecules, while it is not able to deubiquitinate substrates with shorter ubiquitin chains: recognizes ubiquitin chain in position S2 and catalyzes en bloc cleavage of polyubiquitin chains from substrate proteins (By similarity). Probably acts by modulating the barrier properties and mechanical stability of tight junctions via deubiquitination of MARVELD2 and LSR (PubMed:26609154)., [UniProtKB, PubMed, UniProtKB]; USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RT25;Q8BR11;Q8CB37;Q8R251", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061578 K63-linked deubiquitinase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0051402 neuron apoptotic process;GO:0001508 action potential;GO:0006915 apoptotic process;GO:0010996 response to auditory stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P15975-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58774-1", "uniprot_id": [ { "id": "TPM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P58774", "type": "external" } ], "mass": 32837.0, "length": 284, "protein_name": "Tropomyosin beta chain", "gene_name": "Tpm2", "organism": "Mouse", "refseq_name": "tropomyosin beta chain isoform Tpm2.2st", "refseq_ac": [ { "id": "NP_033442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033442", "type": "external" } ], "gene_names_uniprotkb": "Tpm2; Tpm-2", "gene_names_refseq": "Tpm-2; Tpm2; Trop-2", "protein_names_uniprotkb": "Tropomyosin beta chain; Beta-tropomyosin; Tropomyosin-2", "protein_names_refseq": "tropomyosin beta chain isoform Tpm2.2st; tropomyosin beta chain", "tax_id": 10090, "disease": "congenital myopathy 23 (Disease Ontology:DOID:0110932); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:22004); (R-MMU-390522); (R-MMU-445355)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16094730;1733968;21183079;21750661;2461223;34428180;36583994;37507081;38665026;39627609", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (PubMed:16094730)., [UniProtKB, UniProtKB, PubMed]; This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]; Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02560;P46901", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0005862 muscle thin filament tropomyosin", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0043462 regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P58774-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZH2-1", "uniprot_id": [ { "id": "TSR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5HZH2", "type": "external" } ], "mass": 35334.0, "length": 323, "protein_name": "18S rRNA aminocarboxypropyltransferase", "gene_name": "Tsr3", "organism": "Mouse", "refseq_name": "18S rRNA aminocarboxypropyltransferase isoform 2", "refseq_ac": [ { "id": "NP_001157190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157190", "type": "external" } ], "gene_names_uniprotkb": "Tsr3", "gene_names_refseq": "0610007P22Rik; 1110014B11Rik; Tsr3", "protein_names_uniprotkb": "18S rRNA aminocarboxypropyltransferase; 2.5.1.157; 20S S rRNA accumulation protein 3 homolog", "protein_names_refseq": "18S rRNA aminocarboxypropyltransferase isoform 2; 18S rRNA aminocarboxypropyltransferase; 20S S rRNA accumulation protein 3 homolog; probable ribosome biogenesis protein C16orf42 homolog; ribosome biogenesis protein TSR3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68327)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DD00", "ec_number_list": [ { "id": "2.5.1.157", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.157", "type": "external" } ], "go_molecular_function": "GO:0016740 transferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0106388 rRNA small subunit aminocarboxypropyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0030490 maturation of SSU-rRNA;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5HZH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVP1-1", "uniprot_id": [ { "id": "TRIML_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVP1", "type": "external" } ], "mass": 53787.0, "length": 470, "protein_name": "Probable E3 ubiquitin-protein ligase TRIML1", "gene_name": "Triml1", "organism": "Mouse", "refseq_name": "probable E3 ubiquitin-protein ligase TRIML1", "refseq_ac": [ { "id": "NP_808410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808410", "type": "external" } ], "gene_names_uniprotkb": "Triml1", "gene_names_refseq": "4933403D14; Triml1", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase TRIML1; 2.3.2.27; RING-type E3 ubiquitin transferase TRIML1; Tripartite motif family-like protein 1", "protein_names_refseq": "RING-type E3 ubiquitin transferase TRIML1; probable E3 ubiquitin-protein ligase TRIML1; tripartite motif family-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:244448)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19156909", "class_list": "", "function": "Characterized TRIML1, which expresses in embryo before implantation; binding partner of TRIML1, Ubiquitin-specific protease 5 (USP5), was identified, [RefSeq, PubMed]; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. Involved in progression of blastocyst stage and subsequent embryo development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K288-1", "uniprot_id": [ { "id": "TP8L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K288", "type": "external" } ], "mass": 20818.0, "length": 186, "protein_name": "Tumor necrosis factor alpha-induced protein 8-like protein 1", "gene_name": "Tnfaip8l1", "organism": "Mouse", "refseq_name": "tumor necrosis factor alpha-induced protein 8-like protein 1", "refseq_ac": [ { "id": "NP_079842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079842", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip8l1", "gene_names_refseq": "2600017J23Rik; TIPE1; Tnfaip8l1", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8-like protein 1; Oxidative stress regulated gene-beta; Oxy-beta; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1", "protein_names_refseq": "TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; oxidative stress regulated gene-beta; oxy-beta; tumor necrosis factor alpha-induced protein 8-like protein 1; tumor necrosis factor, alpha-induced protein 8-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66443); (R-MMU-1483255)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19878437;21600655;24444419;25043299;30084848;33713358;34428180;36111440;37459052;38754745", "class_list": "", "function": "Acts as a negative regulator of mTOR activity., [UniProtKB, PubMed]; Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation., [RefSeq, PubMed]; TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway, [RefSeq, PubMed]; TIPE1 limits virus replication by disrupting PKM2/ HIF-1alpha/ glycolysis feedback loop., [RefSeq, PubMed]; TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy., [RefSeq, PubMed]; TIPE1(TNFAIP8-like 1)protein was detected in a variety of tissues such as neurons, brain, hepatocytes, germ cells of female and male reproductive organs, muscular tissues and cells of epithelial origin it was not expressed in mature T or B lymphocytes, [RefSeq, PubMed]; TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6E5;Q9D0N6;Q9DBH7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032007 negative regulation of TOR signaling;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K288-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHE7-1", "uniprot_id": [ { "id": "TSSC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHE7", "type": "external" } ], "mass": 33569.0, "length": 317, "protein_name": "U5 small nuclear ribonucleoprotein TSSC4", "gene_name": "Tssc4", "organism": "Mouse", "refseq_name": "U5 small nuclear ribonucleoprotein TSSC4 isoform 1", "refseq_ac": [ { "id": "NP_001108557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108557", "type": "external" } ], "gene_names_uniprotkb": "Tssc4; MNCb-3063", "gene_names_refseq": "ESTM671070; Tssc4", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein TSSC4", "protein_names_refseq": "U5 small nuclear ribonucleoprotein TSSC4 isoform 1; U5 small nuclear ribonucleoprotein TSSC4; protein TSSC4", "tax_id": 10090, "disease": "", "pathway": " (mmu:56844)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10907850;10915772;21183079;21750661;31219806;36852467;40885482", "class_list": "", "function": "Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The orthologous gene pair, Tssc4/TSSC4, shows difference in imprinting between mouse and human. Mouse Tssc4 gene is imprinted, with preferential expression from the maternal allele in placenta, whereas, human TSSC4 gene is not imprinted., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0005682 U5 snRNP", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000387 spliceosomal snRNP assembly;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JHE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50518-1", "uniprot_id": [ { "id": "VATE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P50518", "type": "external" } ], "mass": 26157.0, "length": 226, "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "Atp6v1e1", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit E 1", "refseq_ac": [ { "id": "NP_031536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031536", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1e1; Atp6e2; Atp6e", "gene_names_refseq": "2410029D23Rik; Atp6e2; Atp6e; Atp6v1e1; Atp6v1e; D6Ertd385e; Vma4; p31", "protein_names_uniprotkb": "V-type proton ATPase subunit E 1; V-ATPase 31 kDa subunit; V-ATPase subunit E 1; Vacuolar proton pump subunit E 1; p31", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E; H(+)-ATPase E-like protein; V-ATPase 31 kDa subunit; V-ATPase subunit E 1; V-type proton ATPase subunit E 1; VATPase, H+ transporting, lysosomal V1 subunit E1; vacuolar proton pump subunit E 1", "tax_id": 10090, "disease": "autosomal recessive cutis laxa type IIC (Disease Ontology:DOID:0070140)", "pathway": " (mmu:11973); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11872743;18034455;21750661;23055941;26740625;29993276;33300544;34428180;37507081;39695235;8741845", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:39695235)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UK59;Q8K5D6;Q99LD0", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P50518-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0A6-1", "uniprot_id": [ { "id": "VTM2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0A6", "type": "external" } ], "mass": 25876.0, "length": 236, "protein_name": "V-set and transmembrane domain-containing protein 2A", "gene_name": "Vstm2a", "organism": "Mouse", "refseq_name": "V-set and transmembrane domain-containing protein 2A isoform 2 precursor", "refseq_ac": [ { "id": "NP_666079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666079", "type": "external" } ], "gene_names_uniprotkb": "Vstm2a; Vstm2", "gene_names_refseq": "Vstm2a; Vstm2", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 2A", "protein_names_refseq": "V-set and transmembrane domain-containing protein 2A isoform 2 precursor; V-set and transmembrane domain-containing protein 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:211739)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28052263;33196296", "class_list": "", "function": "Control of adipogenic commitment by a STAT3-VSTM2A axis., [RefSeq, PubMed]; Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0010884 positive regulation of lipid storage;GO:0071773 cellular response to BMP stimulus;GO:0090336 positive regulation of brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R0A6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K23-1", "uniprot_id": [ { "id": "UFSP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K23", "type": "external" } ], "mass": 52515.0, "length": 461, "protein_name": "Ufm1-specific protease 2", "gene_name": "Ufsp2", "organism": "Mouse", "refseq_name": "ufm1-specific protease 2", "refseq_ac": [ { "id": "NP_619609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609", "type": "external" } ], "gene_names_uniprotkb": "Ufsp2", "gene_names_refseq": "1810047C23Rik; Ufsp2", "protein_names_uniprotkb": "Ufm1-specific protease 2; 3.4.22.-; UfSP2", "protein_names_refseq": "ufm1-specific protease 2", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 106 (Disease Ontology:DOID:0070392); Beukes hip dysplasia (Disease Ontology:DOID:0111367)", "pathway": " (mmu:192169)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17182609;21228277;21750661;25245761;25428506;31599954;33372156;33473208;34428180", "class_list": "", "function": "Structure of ubiquitin-fold modifier 1-specific protease UfSP2., [RefSeq, PubMed]; Thiol-dependent isopeptidase that specifically cleaves UFM1, a ubiquitin-like modifier protein, from conjugated proteins, such as CD274/PD-L1, CYB5R3, DDRGK1, MRE11, RPL26/uL24, TRIP4 and RPL26/uL24 (PubMed:17182609, PubMed:21228277, PubMed:33372156). While it is also able to mediate the processing of UFM1 precursors, a prerequisite for conjugation reactions, UFSP2 mainly acts as a protein deUFMylase that mediates deconjugation of UFM1 from target proteins (PubMed:17182609, PubMed:21228277). Mediates deUFMylation of RPL26/uL24, a critical step to release the UFM1 ribosome E3 ligase (UREL) complex during the recycling of 60S ribosome subunits from the endoplasmic reticulum (By similarity). Catalyzes deUFMylation of TRIP4, regulating intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5I0", "ec_number_list": [], "go_molecular_function": "GO:0071567 deUFMylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006508 proteolysis;GO:1903051 negative regulation of proteolysis involved in protein catabolic process;GO:0033146 regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99K23-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RSJ4-1", "uniprot_id": [ { "id": "BLT3B_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RSJ4", "type": "external" } ], "mass": 161940.0, "length": 1457, "protein_name": "Bridge-like lipid transfer protein family member 3B", "gene_name": "Bltp3b", "organism": "Mouse", "refseq_name": "bridge-like lipid transfer protein family member 3B", "refseq_ac": [ { "id": "NP_083442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083442", "type": "external" } ], "gene_names_uniprotkb": "Bltp3b; Kiaa0701; Ship164; Uhrf1bp1l", "gene_names_refseq": "2010319N22Rik; 4930506D01Rik; Bltp3b; E030041M21Rik; Uhrf1bp1l; mKIAA0701", "protein_names_uniprotkb": "Bridge-like lipid transfer protein family member 3B; Syntaxin-6 Habc-interacting protein of 164 kDa; UHRF1-binding protein 1-like", "protein_names_refseq": "UHRF1 (ICBP90) binding protein 1-like; UHRF1-binding protein 1-like; bridge-like lipid transfer protein family member 3B; syntaxin-6 Habc-interacting protein of 164 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:75089); (R-MMU-9696270)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;25428506;30084848;31219806;34203471;34428180", "class_list": "", "function": "Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites. Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RQV0;E9QMH4;Q8CHD4", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0120013 lipid transfer activity;GO:0062069 GARP complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0120009 intermembrane lipid transfer;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2RSJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARP1-1", "uniprot_id": [ { "id": "VIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARP1", "type": "external" } ], "mass": 159923.0, "length": 1436, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "Ppip5k1", "organism": "Mouse", "refseq_name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 5", "refseq_ac": [ { "id": "NP_848910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848910", "type": "external" } ], "gene_names_uniprotkb": "Ppip5k1; Hisppd2a; Kiaa0377; Vip1", "gene_names_refseq": "B430315C20Rik; Hisppd2a; Ppip5k1; mKIAA0377", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; 2.7.4.24; Diphosphoinositol pentakisphosphate kinase 1; Histidine acid phosphatase domain-containing protein 2A; InsP6 and PP-IP5 kinase 1; VIP1 homolog", "protein_names_refseq": "VIP1 homolog; histidine acid phosphatase domain containing 2A; histidine acid phosphatase domain-containing protein 2A; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 5; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; insP6 and PP-IP5 kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:327655); (R-MMU-1855167)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARP2;A2ARP3;A2ARP4;Q6P1C8;Q7TSP1;Q80U21;Q8BL16;Q8BUN6;Q8BVG9", "ec_number_list": [ { "id": "2.7.4.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.24", "type": "external" } ], "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0052723 inositol hexakisphosphate 1-kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2ARP1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AVZ0-1", "uniprot_id": [ { "id": "UPP_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AVZ0", "type": "external" } ], "mass": 34278.0, "length": 310, "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "Uprt", "organism": "Mouse", "refseq_name": "uracil phosphoribosyltransferase homolog", "refseq_ac": [ { "id": "NP_001074658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074658", "type": "external" } ], "gene_names_uniprotkb": "Uprt", "gene_names_refseq": "D830012I24Rik; Gm774; Uprt", "protein_names_uniprotkb": "Uracil phosphoribosyltransferase homolog", "protein_names_refseq": "uracil phosphoribosyltransferase (FUR1) homolog; uracil phosphoribosyltransferase homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:331487)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19433338;21183079;25428506;27461566;28135057", "class_list": "", "function": "CDUPRT-expressing cells were more sensitive to 5-FC and 5-FU than CD-expressing cells. CDUPRT-expression further enhanced the radiosensitizing effect of 5-FC., [RefSeq, PubMed]; Data indicate that a combination cytosine deaminase (CDA)/uracil phosphoribosyltransferase protein (UPRT)-expressing adipose tissue-derived mesenchymal stem cells (AT-MSCs) with lysomustine has a superior antitumor effect in the lung carcinoma model compared to monotherapies with transfected AT-MSCs or lysomustine alone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050262 ribosylnicotinamide kinase activity;GO:0061769 nicotinate riboside kinase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007565 female pregnancy;GO:0032868 response to insulin;GO:0007595 lactation;GO:0006222 UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1AVZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4P1-1", "uniprot_id": [ { "id": "WDFY1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4P1", "type": "external" } ], "mass": 46218.0, "length": 410, "protein_name": "WD repeat and FYVE domain-containing protein 1", "gene_name": "Wdfy1", "organism": "Mouse", "refseq_name": "WD repeat and FYVE domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001104749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104749", "type": "external" } ], "gene_names_uniprotkb": "Wdfy1; Kiaa1435", "gene_names_refseq": "1700013B03Rik; 1700120F24Rik; FENS-1; Jr1; WDF1; Wdfy1; ZFYVE17; mKIAA1435", "protein_names_uniprotkb": "WD repeat and FYVE domain-containing protein 1; WD40- and FYVE domain-containing protein 1", "protein_names_refseq": "WD repeat and FYVE domain-containing protein 1 isoform 1; WD repeat and FYVE domain-containing protein 1; WD40 and FYVE domain containing 1; WD40- and FYVE domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69368)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15345747;21183079;21750661;25736436;33127972;35011620;35121371", "class_list": "", "function": "MiR-511 Deficiency Protects Mice from Experimental Colitis by Reducing TLR3 and TLR4 Responses via WD Repeat and FYVE-Domain-Containing Protein 1. Publication Status: Online-Only, [RefSeq, PubMed]; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436)., [UniProtKB, PubMed]; WDFY1, a WD40 repeat protein, is not essential for spermatogenesis and male fertility in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTX9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0034145 positive regulation of toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q4P1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35633-1", "uniprot_id": [ { "id": "VIAAT_MOUSE", "url": "https://www.uniprot.org/uniprot/O35633", "type": "external" } ], "mass": 57381.0, "length": 525, "protein_name": "Vesicular inhibitory amino acid transporter", "gene_name": "Slc32a1", "organism": "Mouse", "refseq_name": "vesicular inhibitory amino acid transporter", "refseq_ac": [ { "id": "NP_033534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033534", "type": "external" } ], "gene_names_uniprotkb": "Slc32a1; Vgat; Viaat", "gene_names_refseq": "Slc32a1; VGAT; Viaat", "protein_names_uniprotkb": "Vesicular inhibitory amino acid transporter; Solute carrier family 32 member 1; Vesicular GABA and glycine transporter; Vesicular GABA transporter; mVGAT; mVIAAT", "protein_names_refseq": "GABA and glycine transporter; mVGAT; mVIAAT; solute carrier family 32 member 1; vasicular inhibitory amino acid transporter 10D; vesicular GABA and glycine transporter; vesicular GABA transporter a form; vesicular inhibitory amino acid transporter", "tax_id": 10090, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:22348); (R-MMU-442660); (R-MMU-888590)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10036231;12115694;12573541;12882924;16701208;16800626;19052203;22645316;26912364;27601664;32848054;33300544;35822049;36073542;40021952;40885482;9395291", "class_list": "", "function": "Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals (PubMed:16701208, PubMed:26912364, PubMed:27601664, PubMed:9395291). The transport is equally dependent on the chemical and electrical components of the proton gradient (PubMed:27601664, PubMed:9395291). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (PubMed:27601664)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Determined the genomic structure of the mVGAT gene and analyzed the promoter activity of the 5'-flanking sequence, [RefSeq, PubMed]; Functional neuronal VIAAT is present in glucagon-containing secretory granules in pancreatic alpha-cells, [RefSeq, PubMed]; Viaat is expressed in horizontal cells of the outer retina not only at terminals invaginating into cone pedicles but also at terminals contacting rod spherules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0015185 gamma-aminobutyric acid transmembrane transporter activity;GO:0140799 glycine:proton antiporter activity;GO:0140800 gamma-aminobutyric acid:proton antiporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0051286 cell tip;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0015816 glycine transport;GO:0021766 hippocampus development;GO:0015812 gamma-aminobutyric acid transport;GO:0051939 gamma-aminobutyric acid import;GO:0098700 neurotransmitter loading into synaptic vesicle", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O35633-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51863-1", "uniprot_id": [ { "id": "VA0D1_MOUSE", "url": "https://www.uniprot.org/uniprot/P51863", "type": "external" } ], "mass": 40301.0, "length": 351, "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "Atp6v0d1", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit d 1", "refseq_ac": [ { "id": "NP_038505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038505", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0d1; Atp6d", "gene_names_refseq": "Ac39; Atp6d; Atp6v0d1; P39; VATX; Vma6", "protein_names_uniprotkb": "V-type proton ATPase subunit d 1; P39; Physophilin; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; V-ATPase subunit d 1; Vacuolar proton pump subunit d 1", "protein_names_refseq": "ATPase, H+ transporting, V0 subunit D; ATPase, H+ transporting, lysosomal (vacuolar proton pump), 42 kDa; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; V-ATPase subunit d 1; V-type proton ATPase subunit d 1; physophilin; vacuolar proton pump subunit d 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (mmu:11972); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "12527205;12963731;18034455;21183079;25605945;26740625;28315936;29187734;29644770;30084848;33300544;34428180;36640329;9753184", "class_list": "", "function": "ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis., [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:12963731). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (PubMed:12963731). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A57;Q9QWJ2", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005769 early endosome;GO:0005813 centrosome;GO:0016020 membrane;GO:0043679 axon terminus", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006879 intracellular iron ion homeostasis;GO:0060271 cilium assembly;GO:0036295 cellular response to increased oxygen levels;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P51863-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00731-7", "uniprot_id": [ { "id": "VEGFA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00731", "type": "external" } ], "mass": 43131.0, "length": 392, "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "Vegfa", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor A, long form isoform 1", "refseq_ac": [ { "id": "NP_001020421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020421", "type": "external" } ], "gene_names_uniprotkb": "Vegfa; Vegf", "gene_names_refseq": "L-VEGF; Vegfa; Vegf; Vpf", "protein_names_uniprotkb": "Vascular endothelial growth factor A, long form; L-VEGF; VPF; Vascular permeability factor", "protein_names_refseq": "vascular endothelial growth factor A, long form isoform 1; vascular endothelial growth factor A, long form; vascular permeability factor", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); erythema multiforme (Disease Ontology:DOID:0050185); inflammatory bowel disease (Disease Ontology:DOID:0050589); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); brain glioma (Disease Ontology:DOID:0060108); ischemic colitis (Disease Ontology:DOID:0060181); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); vestibular schwannomatosis (Disease Ontology:DOID:0111252); neurofibromatosis 1 (Disease Ontology:DOID:0111253); prostate cancer (Disease Ontology:DOID:10283); retinitis pigmentosa (Disease Ontology:DOID:10584); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); DiGeorge syndrome (Disease Ontology:DOID:11198); pulmonary edema (Disease Ontology:DOID:11396); polycystic ovary syndrome (Disease Ontology:DOID:11612); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); Graves' disease (Disease Ontology:DOID:12361); retinal ischemia (Disease Ontology:DOID:12510); acoustic neuroma (Disease Ontology:DOID:12689); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); adhesions of uterus (Disease Ontology:DOID:13812); interstitial cystitis (Disease Ontology:DOID:13949); adult-onset Still's disease (Disease Ontology:DOID:14256); colon carcinoma (Disease Ontology:DOID:1520); acute chest syndrome (Disease Ontology:DOID:1584); congenital heart disease (Disease Ontology:DOID:1682); glaucoma (Disease Ontology:DOID:1686); neovascular glaucoma (Disease Ontology:DOID:1687); duodenal ulcer (Disease Ontology:DOID:1724); retinal vein occlusion (Disease Ontology:DOID:1727); melanoma (Disease Ontology:DOID:1909); autoimmune hepatitis (Disease Ontology:DOID:2048); colon cancer (Disease Ontology:DOID:219); opiate dependence (Disease Ontology:DOID:2559); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); granulosa cell tumor (Disease Ontology:DOID:2999); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gingivitis (Disease Ontology:DOID:3087); inverted papilloma (Disease Ontology:DOID:3179); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); neurofibrosarcoma (Disease Ontology:DOID:3512); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); seminoma (Disease Ontology:DOID:4440); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); renal Wilms' tumor (Disease Ontology:DOID:5176); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal telangiectasia (Disease Ontology:DOID:7736); extrinsic allergic alveolitis (Disease Ontology:DOID:841); dermatitis herpetiformis (Disease Ontology:DOID:8505); bullous pemphigoid (Disease Ontology:DOID:8506); chronic fatigue syndrome (Disease Ontology:DOID:8544); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); cholesteatoma (Disease Ontology:DOID:869); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); hepatopulmonary syndrome (Disease Ontology:DOID:900); sudden infant death syndrome (Disease Ontology:DOID:9007); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); diabetic neuropathy (Disease Ontology:DOID:9743); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (mmu:22339); (R-MMU-114608); (R-MMU-194313); (R-MMU-195399); (R-MMU-4420097); (R-MMU-5218921)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10878616;1592003;16259067;16293765;1644816;26503042;26789244;35455969;8632007;9446618", "class_list": "", "function": "Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:16293765). May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (PubMed:35455969)., [UniProtKB, PubMed]; This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 107, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8WH81;O70123;Q66S31;Q6GT23;Q6WZL9", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:1902966 positive regulation of protein localization to early endosome;GO:1903672 positive regulation of sprouting angiogenesis;GO:0097533 cellular stress response to acid chemical;GO:0060319 primitive erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q00731-7", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5H8C4-1", "uniprot_id": [ { "id": "VP13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5H8C4", "type": "external" } ], "mass": 359401.0, "length": 3166, "protein_name": "Intermembrane lipid transfer protein VPS13A", "gene_name": "Vps13a", "organism": "Mouse", "refseq_name": "intermembrane lipid transfer protein VPS13A", "refseq_ac": [ { "id": "NP_766616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766616", "type": "external" } ], "gene_names_uniprotkb": "Vps13a; Chac; Kiaa0986", "gene_names_refseq": "4930425F11; 4930516E05Rik; 4930543C13Rik; 9930023P20; Chac; Chorein; D330038K10Rik; Vps13a; mKIAA0986", "protein_names_uniprotkb": "Intermembrane lipid transfer protein VPS13A; Chorea-acanthocytosis protein homolog; Chorein; Vacuolar protein sorting-associated protein 13A", "protein_names_refseq": "chorea-acanthocytosis protein homolog; intermembrane lipid transfer protein VPS13A; vacuolar protein sorting-associated protein 13A", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); choreaacanthocytosis (Disease Ontology:DOID:0050766); Parkinson's disease 23 (Disease Ontology:DOID:0060896); Cohen syndrome (Disease Ontology:DOID:0111590); autosomal recessive spinocerebellar ataxia 4 (Disease Ontology:DOID:0111611); choreatic disease (Disease Ontology:DOID:12859); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:271564)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;15686477;17196930;18250455;18299400;20173027;21183079;21750661;21952136;22366033;24129186;25428506;25428507;25605945;30084848;30779550;31219806;31599954;33300544;34418053;34428180;34678516;35820727;36210013;37828378;39063018", "class_list": "", "function": "Analysis of Brain, Blood, and Testis Phenotypes Lacking the Vps13a Gene in C57BL/6N Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Brain-specific variants of VPS13A may be involved in the brain-specific pathology of chorea-acanthocytosis., [RefSeq, PubMed]; Chorein interacts with beta-adducin and beta-actin., [RefSeq, PubMed]; Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (By similarity). Negatively regulates lipid droplet size and motility (By similarity). Required for efficient lysosomal protein degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mouse CHAC cDNA sequence and the exon-intron structures of the CHAC disease gene are identified and a CHAC model mouse produced by a gene-targeting technique., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQG7;Q3UX03;Q5DU08;Q80YV7;Q8C722", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0045053 protein retention in Golgi apparatus;GO:0006869 lipid transport;GO:0007399 nervous system development;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q5H8C4-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVE8-1", "uniprot_id": [ { "id": "WDR44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NVE8", "type": "external" } ], "mass": 101555.0, "length": 915, "protein_name": "WD repeat-containing protein 44", "gene_name": "Wdr44", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 44", "refseq_ac": [ { "id": "NP_001292604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292604", "type": "external" } ], "gene_names_uniprotkb": "Wdr44; RPH11", "gene_names_refseq": "2610034K17Rik; RAB11BP; RPH11; Wdr44", "protein_names_uniprotkb": "WD repeat-containing protein 44; Rab11-binding protein; Rab11BP; Rabphilin-11", "protein_names_refseq": "WD repeat-containing protein 44; rab11-binding protein; rabphilin-11", "tax_id": 10090, "disease": "", "pathway": " (mmu:72404)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;31219806;34428180", "class_list": "", "function": "Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (By similarity). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (By similarity). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (By similarity). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT13;Q8BTS1", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0030334 regulation of cell migration;GO:0060627 regulation of vesicle-mediated transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6NVE8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLN6-1", "uniprot_id": [ { "id": "UNC80_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLN6", "type": "external" } ], "mass": 370562.0, "length": 3326, "protein_name": "Protein unc-80 homolog", "gene_name": "Unc80", "organism": "Mouse", "refseq_name": "protein unc-80 homolog isoform 2", "refseq_ac": [ { "id": "NP_780719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780719", "type": "external" } ], "gene_names_uniprotkb": "Unc80; Kiaa1843", "gene_names_refseq": "C030018G13Rik; C230061B10Rik; UNC-80; Unc80", "protein_names_uniprotkb": "Protein unc-80 homolog; mUNC-80", "protein_names_refseq": "NALCN channel associated protein; protein unc-80 homolog isoform 2; protein unc-80 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:329178); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19092807;21040849;21183079;21750661;22645316;25428506;26708751;26708753;29187734;32620897;34418053;35820727;36757814;38892173", "class_list": "", "function": "Auxilary subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (PubMed:19092807, PubMed:21040849, PubMed:32620897). The NALCN sodium channel complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:32620897). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current (By similarity). UNC80 is also essential for NALCN sensitivity to extracellular Ca(2+) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception. Publication Status: Online-Only, [RefSeq, PubMed]; In the mouse hippocampal and ventral tegmental area neurons, substance P and neurotensin activate a channel complex containing NALCN and a large previously unknown protein UNC-80, [RefSeq, PubMed]; Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Publication Status: Online-Only, [RefSeq, PubMed]; Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-UNC80-NALCN complex in a G protein-dependent fashion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2KGE8;B2KGG4;B8XCJ6;Q69Z93;Q8BJN5;Q8BLP6", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0034706 sodium channel complex", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0098908 regulation of neuronal action potential;GO:0055080 monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BLN6-1", "record_type": "protein", "filter_code": "0000000.1100101.001000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0E2-1", "uniprot_id": [ { "id": "VP26B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0E2", "type": "external" } ], "mass": 39125.0, "length": 336, "protein_name": "Vacuolar protein sorting-associated protein 26B", "gene_name": "Vps26b", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 26B", "refseq_ac": [ { "id": "NP_821170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_821170", "type": "external" } ], "gene_names_uniprotkb": "Vps26b", "gene_names_refseq": "1810012I05Rik; 2310075A12Rik; Vps26b", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 26B; Vesicle protein sorting 26B", "protein_names_refseq": "vacuolar protein sorting 26 homolog B; vacuolar protein sorting-associated protein 26B; vesicle protein sorting 26B", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:69091)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16190980;18088321;19144319;20875039;21040701;21183079;21920005;25136126;25605945;26740625;30779550;31219806;34428180", "class_list": "", "function": "Acts as a component of the retromer cargo-selective complex (CSC) (PubMed:21040701, PubMed:21920005). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). May be involved in retrograde transport of SORT1 but not of IGF2R (PubMed:21040701). Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (PubMed:25136126)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Both Vps26A and Vps26B are incorporated into retromer complexes through binding of Vps35 to a highly conserved surface patch within the C-terminal subdomain, [RefSeq, PubMed]; These results suggest that mouse Vps26b-Vps29-Vps35 retromer complex is implicated in the transport of sortilin from endosomes to the trans-Golgi network., [RefSeq, PubMed]; Vps26B was found in the cytoplasm with low levels at the plasma membrane, while Vps26A was predominantly associated with endosomal membranes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9768, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN45;Q8K2V3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0071346 cellular response to type II interferon;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8C0E2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Z5-1", "uniprot_id": [ { "id": "VWA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Z5", "type": "external" } ], "mass": 44709.0, "length": 415, "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "Vwa1", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_680085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_680085", "type": "external" } ], "gene_names_uniprotkb": "Vwa1; Warp", "gene_names_refseq": "4932416A11Rik; Vwa1; WARP", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 1; von Willebrand factor A domain-related protein", "protein_names_refseq": "von Willebrand factor A domain-containing protein 1 precursor; von Willebrand factor A domain-containing protein 1; von Willebrand factor A domain-related protein", "tax_id": 10090, "disease": "autosomal recessive distal hereditary motor neuronopathy 7 (Disease Ontology:DOID:0081426); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (mmu:246228); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12062410;14527666;16407285;18314316;18757743;30084848;34428180", "class_list": "", "function": "Evolutionary relationship between von Willebrand factor A-domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens, [RefSeq, PubMed]; Identification of WARP as a component of a limited range of specialized basement membranes provides further evidence for the heterogeneous composition of basement membranes between different tissues, [RefSeq, PubMed]; Promotes matrix assembly (PubMed:18757743). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (By similarity)., [UniProtKB, PubMed, UniProtKB]; WARP forms macromolecular structures that interact with perlecan to contribute to the assembly and/or maintenance of 'permanent' cartilage structures during development and in mature cartilages, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0Q7;Q8VDV9;Q923K3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050436 microfibril binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005614 interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051260 protein homooligomerization;GO:0048266 behavioral response to pain", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R2Z5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDD8-1", "uniprot_id": [ { "id": "WASH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDD8", "type": "external" } ], "mass": 51659.0, "length": 475, "protein_name": "WASH complex subunit 1", "gene_name": "Washc1", "organism": "Mouse", "refseq_name": "WASH complex subunit 1", "refseq_ac": [ { "id": "NP_001032846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032846", "type": "external" } ], "gene_names_uniprotkb": "Washc1; Orf19; Wash1; Wash", "gene_names_refseq": "1110049F14Rik; ORF19; Wash1; Washc1; Wash", "protein_names_uniprotkb": "WASH complex subunit 1; WAS protein family homolog 1", "protein_names_refseq": "WAS protein family homolog 1; WASH complex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68767)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10655549;19732055;19922875;20308062;21750661;22114305;23275443;23974797;24886983;24998208;29084197;31167970;32492429;38086439", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875). Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function (PubMed:23275443). In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (PubMed:24886983). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (PubMed:19732055). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (PubMed:23974797)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice., [RefSeq, PubMed]; Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation., [RefSeq, PubMed]; Show that WASH generates an actin network on a restricted domain of sorting and recycling endosomes., [RefSeq, PubMed]; The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance. Publication Status: Online-Only, [RefSeq, PubMed]; WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U473", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0043014 alpha-tubulin binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030027 lamellipodium", "go_biological_process": "GO:0002468 dendritic cell antigen processing and presentation;GO:1904109 positive regulation of cholesterol import;GO:2000010 positive regulation of protein localization to cell surface;GO:0050776 regulation of immune response;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8VDD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERQ3-1", "uniprot_id": [ { "id": "ZN704_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERQ3", "type": "external" } ], "mass": 61150.0, "length": 566, "protein_name": "Zinc finger protein 704", "gene_name": "Zfp704; Znf704", "organism": "Mouse", "refseq_name": "zinc finger protein 704", "refseq_ac": [ { "id": "NP_573481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573481", "type": "external" } ], "gene_names_uniprotkb": "Zfp704; Znf704; Gig1; Zfp704", "gene_names_refseq": "C030026M03; C030034L19Rik; Gig1; Zfp704; Znf704", "protein_names_uniprotkb": "Zinc finger protein 704; Glucocorticoid-induced gene 1 protein", "protein_names_refseq": "glucocorticoid induced gene 1; glucocorticoid-induced gene 1 protein; zinc finger protein 704", "tax_id": 10090, "disease": "", "pathway": " (mmu:170753); (R-MMU-212436)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17693064;21183079;21750661;22517741;34678516;36852467;40885482", "class_list": "", "function": "Highly related cDNAs Gig1 and Pbf interact with required element MyoD core enhancer; they represent a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes., [RefSeq, PubMed]; Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQL8;Q8BJW9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ERQ3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D2EAC2-1", "uniprot_id": [ { "id": "ZBED6_MOUSE", "url": "https://www.uniprot.org/uniprot/D2EAC2", "type": "external" } ], "mass": 109152.0, "length": 980, "protein_name": "Zinc finger BED domain-containing protein 6", "gene_name": "Zbed6", "organism": "Mouse", "refseq_name": "zinc finger BED domain-containing protein 6", "refseq_ac": [ { "id": "NP_001160024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160024", "type": "external" } ], "gene_names_uniprotkb": "Zbed6", "gene_names_refseq": "667118; Gm38394; Gm8466; MGR; Zbed6", "protein_names_uniprotkb": "Zinc finger BED domain-containing protein 6; MGR; Muscle growth regulator", "protein_names_refseq": "muscle growth regulator; zinc finger BED domain-containing protein 6; zinc finger, BED domain containing 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:667118)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "20016685;20134481;21183079;24043816;24691566;24714595;25428506;26750727;29440408;30084848;30779550;32557799;34296320;34348644;34428180", "class_list": "", "function": "Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs. Publication Status: Online-Only, [RefSeq, PubMed]; Muscle growth regulator (MGR) is a repressor of Igf2, [RefSeq, PubMed]; Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2 expression, cell proliferation, wound healing, and myotube formation., [RefSeq, PubMed]; The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells., [RefSeq, PubMed]; Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells., [RefSeq, PubMed]; Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (PubMed:20016685, PubMed:29440408, PubMed:32557799). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (PubMed:32557799). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (PubMed:20016685, PubMed:32557799). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (PubMed:26750727). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (PubMed:26750727). May also play a role in embryonic beta cell differentiation (PubMed:24043816). May play a role in insulin sensitivity and glucose clearance (PubMed:29440408)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; We propose that ZBED6 preferentially binds to active promoters and modulates transcriptional activity without recruiting repressive histone modifications. Publication Status: Online-Only, [RefSeq, PubMed]; ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation., [RefSeq, PubMed]; ZBED6 inhibits IGF2 activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2EAC3;Q3UMD3;Q8C1U4;Q8CBM9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0034451 centriolar satellite", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "D2EAC2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60821-1", "uniprot_id": [ { "id": "ZBT17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60821", "type": "external" } ], "mass": 86758.0, "length": 794, "protein_name": "Zinc finger and BTB domain-containing protein 17", "gene_name": "Zbtb17", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 17 isoform 1", "refseq_ac": [ { "id": "NP_033567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033567", "type": "external" } ], "gene_names_uniprotkb": "Zbtb17; Zfp100; Znf151", "gene_names_refseq": "Lp-1; Miz1; Zbtb17; Zfp100; mZ13", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 17; LP-1; Polyomavirus late initiator promoter-binding protein; Zfp-100; Zinc finger protein 100; Zinc finger protein 151; Zinc finger protein Z13", "protein_names_refseq": "polyomavirus late initiator promoter-binding protein; zfp-100; zinc finger and BTB domain-containing protein 17 isoform 1; zinc finger and BTB domain-containing protein 17; zinc finger protein 100; zinc finger protein 151; zinc finger protein Z13", "tax_id": 10090, "disease": "", "pathway": " (mmu:22642)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12861998;14560010;20190815;21258009;22184250;23525087;31219806;36538983;37040844;7575457", "class_list": "", "function": "A TNFalpha/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis., [RefSeq, PubMed]; Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10., [RefSeq, PubMed]; The gene encoding Zfp100 has been assigned to murine chromosome 4 band D3/E1., [RefSeq, PubMed]; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADB9;Q60699", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60821-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMA2-1", "uniprot_id": [ { "id": "ZN503_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMA2", "type": "external" } ], "mass": 63036.0, "length": 652, "protein_name": "Zinc finger protein 503", "gene_name": "Znf503", "organism": "Mouse", "refseq_name": "zinc finger protein 503", "refseq_ac": [ { "id": "NP_663434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663434", "type": "external" } ], "gene_names_uniprotkb": "Znf503; Nolz1; Zfp503", "gene_names_refseq": "B830002A16Rik; Nolz-1; Nolz1; Zfp503; Znf503; Zpo2", "protein_names_uniprotkb": "Zinc finger protein 503; Zinc finger protein Nolz-1", "protein_names_refseq": "zinc finger protein 503; zinc finger protein Nolz-1; zinc-finger protein NOLZ1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218820)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14983057;21183079;23806337;24129315;28528544;36326727", "class_list": "", "function": "May function as a transcriptional repressor., [UniProtKB]; Nolz-1 mRNA was dramatically induced on neural induction of P19 embryonal carcinoma cells by retinoic acid, suggesting that Nolz-1 activation may be involved in neural differentiation, [RefSeq, PubMed]; Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCV4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0061351 neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TMA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CL69-1", "uniprot_id": [ { "id": "ZN703_MOUSE", "url": "https://www.uniprot.org/uniprot/P0CL69", "type": "external" } ], "mass": 58730.0, "length": 594, "protein_name": "Zinc finger protein 703", "gene_name": "Zfp703; Znf703", "organism": "Mouse", "refseq_name": "zinc finger protein 703 isoform 1", "refseq_ac": [ { "id": "NP_001094972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094972", "type": "external" } ], "gene_names_uniprotkb": "Zfp703; Znf703; Zeppo1; Zfp703; Zpo1", "gene_names_refseq": "1110032O19Rik; Csmn1; End2; Zeppo1; Zfp703; Znf703; Zpo1", "protein_names_uniprotkb": "Zinc finger protein 703; Zinc finger elbow-related proline domain protein 1", "protein_names_refseq": "ES neuronal differentiation 2; zinc finger elbow-related proline domain protein 1; zinc finger protein 703 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:353310); (R-MMU-212436)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21317240;21750661;22886885;24129315;27090637;32782141", "class_list": "", "function": "Results provide evidence that Zfp703 is a novel feedback suppressor of Wnt/beta-catenin signaling that functions by inhibiting the association of beta-catenin with Tcf1 on Wnt response elements in target gene enhancers. Publication Status: Online-Only, [RefSeq, PubMed]; The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein., [RefSeq, PubMed]; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development., [UniProtKB, PubMed]; Zeppo1 is a key regulator of breast cancer progression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P0CL69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0Q2-1", "uniprot_id": [ { "id": "ZHX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0Q2", "type": "external" } ], "mass": 104343.0, "length": 951, "protein_name": "Zinc fingers and homeoboxes protein 3", "gene_name": "Zhx3", "organism": "Mouse", "refseq_name": "zinc fingers and homeoboxes protein 3", "refseq_ac": [ { "id": "NP_796237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796237", "type": "external" } ], "gene_names_uniprotkb": "Zhx3; Kiaa0395; Tix1", "gene_names_refseq": "1810059C13Rik; 4932418O04Rik; 9530010N21Rik; Tix1; Zhx3; mKIAA0395", "protein_names_uniprotkb": "Zinc fingers and homeoboxes protein 3; Triple homeobox protein 1; Zinc finger and homeodomain protein 3", "protein_names_refseq": "triple homeobox 1; triple homeobox protein 1; zinc finger and homeodomain protein 3; zinc fingers and homeoboxes protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:320799)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14659886;17056598;17242355;21183079;21750661;25428506;40885482;40997131", "class_list": "", "function": "Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA., [UniProtKB]; ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80U14", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C0Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IR42-1", "uniprot_id": [ { "id": "ZCPW1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IR42", "type": "external" } ], "mass": 70569.0, "length": 630, "protein_name": "Zinc finger CW-type PWWP domain protein 1", "gene_name": "Zcwpw1", "organism": "Mouse", "refseq_name": "zinc finger CW-type PWWP domain protein 1", "refseq_ac": [ { "id": "NP_001005426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005426", "type": "external" } ], "gene_names_uniprotkb": "Zcwpw1; Gm1053", "gene_names_refseq": "Gm1053; Zcwpw1", "protein_names_uniprotkb": "Zinc finger CW-type PWWP domain protein 1", "protein_names_refseq": "zinc finger CW-type PWWP domain protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381678)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16926269;21183079;21750661;31453335;32352380;32374261;32744506;37315217", "class_list": "", "function": "Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) that facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (PubMed:32352380, PubMed:32374261, PubMed:32744506). Essential for male fertility and spermatogenesis (PubMed:31453335, PubMed:32352380, PubMed:32374261, PubMed:32744506). Required for meiosis prophase I progression in male but not in female germ cells (PubMed:31453335)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells., [RefSeq, PubMed]; The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that ZCWPW1 may represent a previously unknown, sex-dependent epigenetic regulator of germ cell meiosis in mammals. Publication Status: Online-Only, [RefSeq, PubMed]; ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2YFS4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140566 histone reader activity;GO:0140002 histone H3K4me3 reader activity;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001741 XY body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0040029 epigenetic regulation of gene expression;GO:0007129 homologous chromosome pairing at meiosis;GO:1990918 double-strand break repair involved in meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IR42-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "I7HJS4-1", "uniprot_id": [ { "id": "ZN683_MOUSE", "url": "https://www.uniprot.org/uniprot/I7HJS4", "type": "external" } ], "mass": 50419.0, "length": 458, "protein_name": "Tissue-resident T-cell transcription regulator protein ZNF683", "gene_name": "Znf683", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Znf683; Gm13060; Zfp683", "gene_names_refseq": "", "protein_names_uniprotkb": "Tissue-resident T-cell transcription regulator protein ZNF683; Hobit; Homolog of Blimp-1 in T-cell; Zinc finger protein 683", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22885984;27102484;34428180", "class_list": "", "function": "Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:22885984, PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T-cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:22885984, PubMed:27102484). Also plays a role in the differentiation of both thymic and peripheral NKT cells (PubMed:22885984). Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation (PubMed:22885984). Positively regulates granzyme B production in NKT cells after innate stimulation (PubMed:22885984). Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions (PubMed:27102484)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0032823 regulation of natural killer cell differentiation;GO:0033082 regulation of extrathymic T cell differentiation;GO:0051136 regulation of NK T cell differentiation;GO:0032826 regulation of natural killer cell differentiation involved in immune response;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "I7HJS4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55194-1", "uniprot_id": [ { "id": "3BP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P55194", "type": "external" } ], "mass": 74172.0, "length": 680, "protein_name": "SH3 domain-binding protein 1", "gene_name": "Sh3bp1", "organism": "Mouse", "refseq_name": "SH3 domain-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001303613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303613", "type": "external" } ], "gene_names_uniprotkb": "Sh3bp1; 3bp1", "gene_names_refseq": "3BP-1; Sh3bp1", "protein_names_uniprotkb": "SH3 domain-binding protein 1; 3BP-1", "protein_names_refseq": "SH3 domain-binding protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20401); (R-MMU-9013149)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10508610;1379745;19144319;21183079;21750661;22891260;24129315;25428506;26495903;30084848;30779550;34428180;35820727;40885482;7621827;8438166", "class_list": "", "function": "GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form (PubMed:7621827). By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A5V4;E9QMQ2;Q99KK8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0030215 semaphorin receptor binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0030834 regulation of actin filament depolymerization;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P55194-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83510-1", "uniprot_id": [ { "id": "TNIK_MOUSE", "url": "https://www.uniprot.org/uniprot/P83510", "type": "external" } ], "mass": 150367.0, "length": 1323, "protein_name": "Traf2 and NCK-interacting protein kinase", "gene_name": "Tnik", "organism": "Mouse", "refseq_name": "traf2 and NCK-interacting protein kinase isoform 3", "refseq_ac": [ { "id": "NP_001156480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156480", "type": "external" } ], "gene_names_uniprotkb": "Tnik; Kiaa0551", "gene_names_refseq": "1500031A17Rik; 4831440I19Rik; C530008O15Rik; C630040K21Rik; Tnik", "protein_names_uniprotkb": "Traf2 and NCK-interacting protein kinase; 2.7.11.1", "protein_names_refseq": "traf2 and NCK-interacting protein kinase isoform 3; traf2 and NCK-interacting protein kinase", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 54 (Disease Ontology:DOID:0081216); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:665113); (R-MMU-2559580)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;19816403;20159449;21158410;21183079;21750661;22517741;32848054;33300544;34077555;34428180;34677004;35822049;36210013;37556547;40021952;40885482", "class_list": "", "function": "Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK., [RefSeq, PubMed]; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway., [UniProtKB, UniProtKB]; SiRNA depletion of TNIK followed by expression array analysis showed that TNIK is an essential, specific activator of Wnt transcriptional programme. Erratum:[EMBO J. 2025 Aug;44(15):4407. doi: 10.1038/s44318-025-00393-5. PMID: 40634670], [RefSeq, PubMed]; TNIK is a conserved regulator of glucose and lipid metabolism in obesity., [RefSeq, PubMed]; Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0048814 regulation of dendrite morphogenesis;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P83510-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VNB8-1", "uniprot_id": [ { "id": "WDFY3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VNB8", "type": "external" } ], "mass": 392338.0, "length": 3508, "protein_name": "WD repeat and FYVE domain-containing protein 3", "gene_name": "Wdfy3", "organism": "Mouse", "refseq_name": "WD repeat and FYVE domain-containing protein 3", "refseq_ac": [ { "id": "NP_766470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766470", "type": "external" } ], "gene_names_uniprotkb": "Wdfy3", "gene_names_refseq": "2610509D04Rik; ALFY; B930017C24; BWF1; Bchs; D5Ertd66e; Ggtb3; Wdfy3; ZFYVE25; mKIAA0993", "protein_names_uniprotkb": "WD repeat and FYVE domain-containing protein 3; BWF1; Beach domain, WD repeat and FYVE domain-containing protein 1", "protein_names_refseq": "WD repeat and FYVE domain-containing protein 3; beach domain, WD repeat and FYVE domain-containing protein 1; galactosyltransferase 3 beta 1, 4", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary autosomal dominant microcephaly 18 (Disease Ontology:DOID:0070295); Chediak-Higashi syndrome (Disease Ontology:DOID:2935)", "pathway": " (mmu:72145)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15292400;15342963;19144319;20173027;21183079;21750661;22645316;22872234;25198012;25428506;27330028;27648578;30016717;31219806;33300544;34428180;35820727;35822049;36210013;36566259", "class_list": "", "function": "A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Important for normal brain development (PubMed:25198012, PubMed:27648578). Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (PubMed:27648578). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (By similarity). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (PubMed:27330028). After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8H7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005545 1-phosphatidylinositol binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035973 aggrephagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q6VNB8-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERF3-1", "uniprot_id": [ { "id": "SKI8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERF3", "type": "external" } ], "mass": 33773.0, "length": 305, "protein_name": "Superkiller complex protein 8", "gene_name": "Skic8", "organism": "Mouse", "refseq_name": "superkiller complex protein 8 isoform a", "refseq_ac": [ { "id": "NP_001020546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020546", "type": "external" } ], "gene_names_uniprotkb": "Skic8; Wdr61", "gene_names_refseq": "2700038L12Rik; 2810418I05Rik; REC14; Ski8; Skic8; Wdr61", "protein_names_uniprotkb": "Superkiller complex protein 8; Meiotic recombination REC14 protein homolog; Ski8; WD repeat-containing protein 61, N-terminally processed; WD repeat-containing protein 61", "protein_names_refseq": "SKI8 subunit of superkiller complex protein; WD repeat domain 61; WD repeat-containing protein 61; meiotic recombination protein REC14; superkiller complex protein 8 isoform a; superkiller complex protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:66317); (R-MMU-112382); (R-MMU-429958); (R-MMU-674695); (R-MMU-75955); (R-MMU-8866654)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "19345177;21750661;27749823;31219806;37828378", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency (PubMed:19345177). PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 (By similarity). PAF1C is required for transcription of Hox and Wnt target genes (By similarity). PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL (By similarity). PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription (By similarity). PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors (By similarity). In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription (By similarity). Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3) (By similarity). Required for Hox gene transcription (By similarity). Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (By similarity). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (By similarity). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U562;Q9CZP1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0055087 Ski complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0016055 Wnt signaling pathway;GO:0006368 transcription elongation by RNA polymerase II;GO:0000956 nuclear-transcribed mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ERF3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7W4-1", "uniprot_id": [ { "id": "TSN17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7W4", "type": "external" } ], "mass": 30126.0, "length": 270, "protein_name": "Tetraspanin-17", "gene_name": "Tspan17", "organism": "Mouse", "refseq_name": "tetraspanin-17", "refseq_ac": [ { "id": "NP_083117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083117", "type": "external" } ], "gene_names_uniprotkb": "Tspan17; Fbxo23; Tm4sf17", "gene_names_refseq": "2210021G21Rik; Fbxo23; Tm4sf17; Tspan17", "protein_names_uniprotkb": "Tetraspanin-17; F-box only protein 23; Tetraspan protein SB134; Transmembrane 4 superfamily member 17; Tspan-17", "protein_names_refseq": "F-box only protein 23; tetraspan protein SB134; tetraspanin-17; transmembrane 4 superfamily member 17; tspan-17", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:74257)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23035126;26668317", "class_list": "", "function": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91VI6", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0051604 protein maturation;GO:0051043 regulation of membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7W4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMG3-1", "uniprot_id": [ { "id": "TMUB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMG3", "type": "external" } ], "mass": 26316.0, "length": 245, "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "Tmub1", "organism": "Mouse", "refseq_name": "transmembrane and ubiquitin-like domain-containing protein 1", "refseq_ac": [ { "id": "NP_071863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071863", "type": "external" } ], "gene_names_uniprotkb": "Tmub1; Hops", "gene_names_refseq": "2010004O20Rik; Hops; Tmub1", "protein_names_uniprotkb": "Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein", "protein_names_refseq": "hepatocyte odd protein shuttling protein; transmembrane and ubiquitin-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64295)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10679242;16014383;18418082;18665261;20582322;21750661;22890319;24240191;26495903;30610893;31867855;33060567;33543240;34281239;34428180", "class_list": "", "function": "Functional expression and localisation of HOPS/TMUB1 in mouse lens., [RefSeq, PubMed]; HOPS is involved in centrosome assembly and maintenance., [RefSeq, PubMed]; HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis., [RefSeq, PubMed]; HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6. Publication Status: Online-Only, [RefSeq, PubMed]; Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as a negative regulator of hepatocyte growth during regeneration., [UniProtKB, UniProtKB, UniProtKB]; May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (PubMed:16014383). May be involved in centrosome assembly (PubMed:18418082). Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (PubMed:22890319)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The results of this study suggest that Tmub1 is an important negative regulator of hepatocyte proliferation in liver regeneration through STAT3 (signal transducer and activator of transcription 3 protein) signaling., [RefSeq, PubMed]; Transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GluR2 to the plasma membrane Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53AQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005813 centrosome;GO:0045211 postsynaptic membrane;GO:0098944 postsynaptic recycling endosome membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JMG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64514-1", "uniprot_id": [ { "id": "TPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64514", "type": "external" } ], "mass": 139879.0, "length": 1262, "protein_name": "Tripeptidyl-peptidase 2", "gene_name": "Tpp2", "organism": "Mouse", "refseq_name": "tripeptidyl-peptidase 2 isoform 2", "refseq_ac": [ { "id": "NP_001297469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297469", "type": "external" } ], "gene_names_uniprotkb": "Tpp2", "gene_names_refseq": "TPP-2; Tpp2; TppII", "protein_names_uniprotkb": "Tripeptidyl-peptidase 2; 3.4.14.10; TPP-2; TPP-II; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II", "protein_names_refseq": "TPP-II; tripeptidyl aminopeptidase; tripeptidyl-peptidase 2 isoform 2; tripeptidyl-peptidase 2", "tax_id": 10090, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (mmu:22019); (R-MMU-983168)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;17932511;19747897;21750661;22266401;22645316;23806337;23818952;25153642;25428506;28528544;30084848;31219806;34418053;34428180;35820727;37507081;38389851;39627609;7998988", "class_list": "", "function": "Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis (By similarity). Stimulates adipogenesis (PubMed:17932511)., [UniProtKB, PubMed, UniProtKB]; Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR. Publication Status: Online-Only, [RefSeq, PubMed]; Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases., [RefSeq, PubMed]; Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5D072", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14", "type": "external" }, { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008240 tripeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0080144 intracellular amino acid homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q64514-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH72-1", "uniprot_id": [ { "id": "TRI32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CH72", "type": "external" } ], "mass": 72057.0, "length": 655, "protein_name": "E3 ubiquitin-protein ligase TRIM32", "gene_name": "Trim32", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM32", "refseq_ac": [ { "id": "NP_001155254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155254", "type": "external" } ], "gene_names_uniprotkb": "Trim32", "gene_names_refseq": "1810045E12Rik; 3f3; BBS11; Trim32; Zfp117", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM32; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM32; Tripartite motif-containing protein 32", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM32; RING-type E3 ubiquitin transferase TRIM32; bM468K2.2 (tripartite motif protein 32); tripartite motif protein 32; tripartite motif-containing protein 32; zinc finger protein 117", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 11 (Disease Ontology:DOID:0110133); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:69807); (R-MMU-3134975); (R-MMU-983168)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "14578165;16816390;21183079;21750661;25428506;26495903;28011936;28898289;30084848;31599954;33725478;34428180;34783942;35159260;35820727;36374170;37415157;37828378", "class_list": "", "function": "E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:14578165, PubMed:37415157). Plays a role in virus-triggered induction of IFN-beta and TNF by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1. Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (By similarity). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions. Ubiquitinates XIAP and targets it for proteasomal degradation. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation. Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (By similarity). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-41' to initiate autophagy (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3beta/Nrf2 Pathway., [RefSeq, PubMed]; Tripartite motif-containing protein 32 regulates Ca[2+] movement in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K055", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005776 autophagosome;GO:0005863 striated muscle myosin thick filament", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:1902018 negative regulation of cilium assembly;GO:0044790 suppression of viral release by host;GO:0007014 actin ubiquitination;GO:1903883 positive regulation of interleukin-17-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CH72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LG0-1", "uniprot_id": [ { "id": "UBP16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LG0", "type": "external" } ], "mass": 93434.0, "length": 825, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 16", "gene_name": "Usp16", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 16", "refseq_ac": [ { "id": "NP_077220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077220", "type": "external" } ], "gene_names_uniprotkb": "Usp16", "gene_names_refseq": "1200004E02Rik; 2810483I07Rik; 6330514E22Rik; UBPM; Usp16", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 16; 3.4.19.12; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16", "protein_names_refseq": "deubiquitinating enzyme 16; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific protease 16; ubiquitin thioesterase 16; ubiquitin thiolesterase 16; ubiquitin-specific-processing protease 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:74112); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "17242355;21183079;21750661;24025767;24034696;24784029;31219806;31599954;34418053;34428180;35311644;35640597;36206347;37777507", "class_list": "", "function": "FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that USP16 has an important role in antagonizing the self-renewal and/or senescence pathways in Down's syndrome and could serve as an attractive target to ameliorate some of the associated pathologies, [RefSeq, PubMed]; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:24034696). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:24034696). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit. Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability (PubMed:36206347)., [UniProtKB, PubMed, HAMAP, PubMed, UniProtKB, UniProtKB]; Study identifies Usp16 and H2A deubiquitination as critical regulators of ESC gene expression and differentiation Publication Status: Online-Only, [RefSeq, PubMed]; USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E860;Q99KM0", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0043024 ribosomal small subunit binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99LG0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WC3-1", "uniprot_id": [ { "id": "TNC18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WC3", "type": "external" } ], "mass": 307635.0, "length": 2878, "protein_name": "Trinucleotide repeat-containing gene 18 protein", "gene_name": "Tnrc18", "organism": "Mouse", "refseq_name": "trinucleotide repeat-containing gene 18 protein isoform A", "refseq_ac": [ { "id": "NP_001116202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116202", "type": "external" } ], "gene_names_uniprotkb": "Tnrc18; Kiaa1856; Zfp469", "gene_names_refseq": "EG381742; Tnrc18; Zfp469", "protein_names_uniprotkb": "Trinucleotide repeat-containing gene 18 protein; Zinc finger protein 469", "protein_names_refseq": "trinucleotide repeat-containing gene 18 protein isoform A; trinucleotide repeat-containing gene 18 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:231861)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;31219806;34428180;36852467;37774938;37938770;40997131", "class_list": "", "function": "Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia., [RefSeq, PubMed]; Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12. Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZJ7;Q69Z86", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0071168 protein localization to chromatin;GO:0141005 transposable element silencing by heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80WC3-1", "record_type": "protein", "filter_code": "0000000.0100101.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21107-1", "uniprot_id": [ { "id": "TPM3_MOUSE", "url": "https://www.uniprot.org/uniprot/P21107", "type": "external" } ], "mass": 32994.0, "length": 285, "protein_name": "Tropomyosin alpha-3 chain", "gene_name": "Tpm3", "organism": "Mouse", "refseq_name": "tropomyosin alpha-3 chain isoform Tpm3.1cy", "refseq_ac": [ { "id": "NP_001240667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240667", "type": "external" } ], "gene_names_uniprotkb": "Tpm3; Tpm-5; Tpm5", "gene_names_refseq": "TM30nm; TMnm; Tm5NM; Tpm-5; Tpm3; Tpm5; Trop-5; gamma-TM; hTM30nm; hTMnm", "protein_names_uniprotkb": "Tropomyosin alpha-3 chain; Gamma-tropomyosin; Tropomyosin-3", "protein_names_refseq": "gamma-tropomyosin; skalphaTM.2; tropomyosin 5; tropomyosin alpha-3 chain isoform Tpm3.1cy; tropomyosin alpha-3 chain; tropomyosin-3", "tax_id": 10090, "disease": "congenital myopathy 4A (Disease Ontology:DOID:0080102); congenital myopathy 4B (Disease Ontology:DOID:0110926); dilated cardiomyopathy (Disease Ontology:DOID:12930); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:59069); (R-MMU-390522); (R-MMU-445355); (R-MMU-9013424)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10889038;21183079;21750661;2400784;26495903;31219806;33807093;34428180;37453647;8491774", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments., [UniProtKB, UniProtKB]; Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to Reduced Cell Complexity in Cultured Hippocampal Neurons-New Insights into the Role of the C-Terminal Region of Tpm3.1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q09021;Q60606;Q80SW6;Q9EPW3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030426 growth cone", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P21107-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24529-1", "uniprot_id": [ { "id": "TY3H_MOUSE", "url": "https://www.uniprot.org/uniprot/P24529", "type": "external" } ], "mass": 55993.0, "length": 498, "protein_name": "Tyrosine 3-monooxygenase", "gene_name": "Th", "organism": "Mouse", "refseq_name": "tyrosine 3-monooxygenase", "refseq_ac": [ { "id": "NP_033403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033403", "type": "external" } ], "gene_names_uniprotkb": "Th", "gene_names_refseq": "Th", "protein_names_uniprotkb": "Tyrosine 3-monooxygenase; 1.14.16.2; TH; Tyrosine 3-hydroxylase", "protein_names_refseq": "tyrosine 3-hydroxylase; tyrosine 3-monooxygenase", "tax_id": 10090, "disease": "autosomal recessive Segawa syndrome (Disease Ontology:DOID:0051059); withdrawal disorder (Disease Ontology:DOID:0060001); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700); Parkinson's disease (Disease Ontology:DOID:14330); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); middle cerebral artery infarction (Disease Ontology:DOID:3525); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:21823); (R-MMU-209905)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "1361189;15008900;15471880;16051392;16677213;1674869;17296554;18500758;19500577;19683335;21183079;21750661;22430860;22713675;22738763;26509576;27935981;28637871;30936473;33300544;34203471;7715703", "class_list": "", "function": "Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (PubMed:30936473)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.2", "type": "external" } ], "go_molecular_function": "GO:0034617 tetrahydrobiopterin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005790 smooth endoplasmic reticulum;GO:0030424 axon", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0006585 dopamine biosynthetic process from tyrosine;GO:0007507 heart development;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P24529-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58771-1", "uniprot_id": [ { "id": "TPM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P58771", "type": "external" } ], "mass": 32681.0, "length": 284, "protein_name": "Tropomyosin alpha-1 chain", "gene_name": "Tpm1", "organism": "Mouse", "refseq_name": "tropomyosin alpha-1 chain isoform Tpm1.1st", "refseq_ac": [ { "id": "NP_001157720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157720", "type": "external" } ], "gene_names_uniprotkb": "Tpm1; Tpm-1; Tpma", "gene_names_refseq": "TM2; TPM1kappa; Tm3; Tmpa; Tpm-1; Tpm1; alpha-TM", "protein_names_uniprotkb": "Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1", "protein_names_refseq": "alpha-tropomyosin; tropomyosin 1 kappa; tropomyosin alpha-1 chain isoform Tpm1.1st; tropomyosin alpha-1 chain; tropomyosin-1", "tax_id": 10090, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 3 (Disease Ontology:DOID:0110309); dilated cardiomyopathy 1Y (Disease Ontology:DOID:0110457); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:22003); (R-MMU-390522); (R-MMU-445355)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "17242355;21183079;21750661;2521606;25428506;28528544;30084848;3244365;34428180;36288343;37507081;38664789;39214082;39927985;7522680", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments., [UniProtKB, UniProtKB]; Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis., [RefSeq, PubMed]; Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02558;P19354;P46902;P99034", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0003065 positive regulation of heart rate by epinephrine;GO:0001701 in utero embryonic development;GO:0007015 actin filament organization;GO:0045785 positive regulation of cell adhesion;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P58771-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WC1-1", "uniprot_id": [ { "id": "UBN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WC1", "type": "external" } ], "mass": 141740.0, "length": 1314, "protein_name": "Ubinuclein-2", "gene_name": "Ubn2", "organism": "Mouse", "refseq_name": "ubinuclein-2", "refseq_ac": [ { "id": "NP_796159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796159", "type": "external" } ], "gene_names_uniprotkb": "Ubn2; Kiaa2030", "gene_names_refseq": "2900060J04Rik; 6030408G03Rik; D130059P03Rik; Ubn2; mKIAA2030", "protein_names_uniprotkb": "Ubinuclein-2", "protein_names_refseq": "ubinuclein-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320538)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21183079;21750661;22872234;23806337;30084848;30285846;30779550;31219806;32782141;34428180;36084651;36852467;40885482;40997131", "class_list": "", "function": "This study demonstrates that the UBN1 or UBN2 subunit is mainly responsible for specific recognition and direct binding of H3.3 by the HIRA complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z27;Q80ZZ9;Q8BQ40;Q8BRI2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000417 HIR complex", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q80WC1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2I3BR58-1", "uniprot_id": [ { "id": "A0A2I3BR58_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A2I3BR58", "type": "external" } ], "mass": 19219.0, "length": 162, "protein_name": "Predicted gene 5624", "gene_name": "Gm5624", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm5624", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 5624", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2I3BR58-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2I3BPJ2-1", "uniprot_id": [ { "id": "A0A2I3BPJ2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A2I3BPJ2", "type": "external" } ], "mass": 64231.0, "length": 573, "protein_name": "Predicted gene, 30083", "gene_name": "Gm30083", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC102631856 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001361094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001361094", "type": "external" } ], "gene_names_uniprotkb": "Gm30083", "gene_names_refseq": "Gm30083", "protein_names_uniprotkb": "Predicted gene, 30083", "protein_names_refseq": "anthrax toxin receptor-like; uncharacterized protein LOC102631856 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:102631856)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2I3BPJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2I3BPX0-1", "uniprot_id": [ { "id": "A0A2I3BPX0_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A2I3BPX0", "type": "external" } ], "mass": 35880.0, "length": 319, "protein_name": "Olfactory receptor", "gene_name": "Or5d3", "organism": "Mouse", "refseq_name": "olfactory receptor family 5 subfamily D member 3, pseudogene 1", "refseq_ac": [ { "id": "NP_001423052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423052", "type": "external" } ], "gene_names_uniprotkb": "Or5d3; Olfr1177-ps; Olfr1177", "gene_names_refseq": "MOR174-19; Olfr1177-ps; Olfr1177; Or5d3", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-49829472-49828534; olfactory receptor 1177, pseudogene; olfactory receptor family 5 subfamily D member 3, pseudogene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545443)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2I3BPX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A2I3BQG2-1", "uniprot_id": [ { "id": "A0A2I3BQG2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A2I3BQG2", "type": "external" } ], "mass": 197826.0, "length": 1825, "protein_name": "Crystallin beta-gamma domain containing 2", "gene_name": "Crybg2", 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Map3k7ip1", "gene_names_refseq": "2310012M03Rik; Map3k7ip1; Tab1; b2b449Clo", "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1; TGF-beta-activated kinase 1-binding protein 1", "protein_names_refseq": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Tak1-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:66513); (R-MMU-168638); (R-MMU-2871837); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-5357956); (R-MMU-5607764); (R-MMU-5689880); (R-MMU-9020702); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-975163)", "pathway_count": 14, "publication_count": 22, "publication_id_list": "12464436;17205106;17932218;21183079;21750661;22517741;22645316;23443134;24037507;28073917;29237092;30016717;30059200;32782141;32848054;35352799;35822049;36409439;36852467;37832545;40021952;40885482", "class_list": "", "function": "Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1., [RefSeq, PubMed]; Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:12464436, PubMed:28073917). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:24037507). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1., [RefSeq, PubMed]; TAB1 plays an important role in mammalian embryogenesis and is required for TAK1 activation in TGF-beta signaling, [RefSeq, PubMed]; TAB1alpha, but not TAB1beta, plays an important role in the activation of p38 in insulin-producing cells and therefore also in cytokine-induced beta-cell death., [RefSeq, PubMed]; We propose that TAB1 promotes nitric oxide-induced p38 autophosphorylation. In addition, nitric oxide-induced p38 activation seems to promote JNK inhibition and ERK activation, but this effect appears to not require TAB1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQJ5;Q80V65;Q8R0D1", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0030324 lung development;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8CF89-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPQ8-1", "uniprot_id": [ { "id": "TCF20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPQ8", "type": "external" } ], "mass": 215683.0, "length": 1987, "protein_name": "Transcription factor 20", "gene_name": "Tcf20", "organism": "Mouse", "refseq_name": "transcription factor 20 isoform a", "refseq_ac": [ { "id": "NP_001107612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107612", "type": "external" } ], "gene_names_uniprotkb": "Tcf20; Spbp", "gene_names_refseq": "2810438H08Rik; SPBP; Tcf20; mKIAA0292", "protein_names_uniprotkb": "Transcription factor 20; Nuclear factor SPBP; SPRE-binding protein; Stromelysin-1 PDGF-responsive element-binding protein; TCF-20", "protein_names_refseq": "SPRE-binding protein; TCF-20; nuclear factor SPBP; stromelysin PDGF responsive element binding protein transcription factor; stromelysin-1 PDGF-responsive element-binding protein; transcription factor 20 isoform a", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Phelan-McDermid syndrome (Disease Ontology:DOID:0080354)", "pathway": " (mmu:21411)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10849425;10995766;17242355;19144319;21183079;21606357;21750661;22645316;23806337;30084848;32782141;32848054;34428180;35074918;36852467;40885482;7760812;8663478", "class_list": "", "function": "Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders., [RefSeq, PubMed]; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B9EHJ7;Q60792", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9EPQ8-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKD1-1", "uniprot_id": [ { "id": "31F12_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKD1", "type": "external" } ], "mass": 146156.0, "length": 1308, "protein_name": "Spermatogenesis-associated protein 31F1B", "gene_name": "Spata31f1b", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 31F1B isoform 1", "refseq_ac": [ { "id": "NP_001078999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078999", "type": "external" } ], "gene_names_uniprotkb": "Spata31f1b; Fam205a2; Gm13298; Spata31f1-2", "gene_names_refseq": "Fam205a2; Fam205a; Gm13298; Spata31f1-2; Spata31f1b", "protein_names_uniprotkb": "Spermatogenesis-associated protein 31F1B; Protein FAM205A-2; Protein SPATA31F1-2", "protein_names_refseq": "Transmembrane protein C9orf144B homolog; family with sequence similarity 205, member A2; protein FAM205A-2; protein FAM205A; protein SPATA31F1-2; spermatogenesis-associated protein 31F1B isoform 1; spermatogenesis-associated protein 31F1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:545611)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34418053;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2APU8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "C0HKD1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKD2-1", "uniprot_id": [ { "id": "31F13_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKD2", "type": "external" } ], "mass": 146156.0, "length": 1308, "protein_name": "Spermatogenesis-associated protein 31F1C", "gene_name": "Spata31f1c", "organism": "Mouse", "refseq_name": "protein SPATA31F1-3 isoform X1", "refseq_ac": [ { "id": "XP_003688841", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003688841", "type": "external" } ], "gene_names_uniprotkb": "Spata31f1c; Fam205a3; Spata31f1-3", "gene_names_refseq": "Fam205a3; Fam205a; Gm21598; Spata31f1-3; Spata31f1c", "protein_names_uniprotkb": "Spermatogenesis-associated protein 31F1C; Protein FAM205A-3; Protein SPATA31F1-3", "protein_names_refseq": "protein SPATA31F1-3 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545611)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APU8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "C0HKD2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKD3-1", "uniprot_id": [ { "id": "31F14_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKD3", "type": "external" } ], "mass": 146156.0, "length": 1308, "protein_name": "Spermatogenesis-associated protein 31F1D", "gene_name": "Spata31f1d", "organism": "Mouse", "refseq_name": "protein SPATA31F1-4 isoform X1", "refseq_ac": [ { "id": "XP_001481289", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001481289", "type": "external" } ], "gene_names_uniprotkb": "Spata31f1d; Fam205a4; Spata31f1-4", "gene_names_refseq": "Fam205a4; Fam205a; Gm20938; Spata31f1-4; Spata31f1d", "protein_names_uniprotkb": "Spermatogenesis-associated protein 31F1D; Protein FAM205A-4; Protein SPATA31F1-4", "protein_names_refseq": "protein SPATA31F1-4 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545611)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APU8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C0HKD3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00520-1", "uniprot_id": [ { "id": "ABL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P00520", "type": "external" } ], "mass": 122673.0, "length": 1123, "protein_name": "Tyrosine-protein kinase ABL1", "gene_name": "Abl1", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase ABL1 isoform a", "refseq_ac": [ { "id": "NP_001106174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106174", "type": "external" } ], "gene_names_uniprotkb": "Abl1; Abl", "gene_names_refseq": "Abl1; Abl; E430008G22Rik; c-Abl", "protein_names_uniprotkb": "Tyrosine-protein kinase ABL1; 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150", "protein_names_refseq": "Abelson murine leukemia oncogene; Abelson tyrosine-protein kinase 1; abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-abl protein, type III; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1 isoform a; v-abl Abelson murine leukemia oncogene 1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); stomach cancer (Disease Ontology:DOID:10534); Parkinson's disease (Disease Ontology:DOID:14330); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophagus adenocarcinoma (Disease Ontology:DOID:4914); ureteral obstruction (Disease Ontology:DOID:5199); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11350); (R-MMU-2029482); (R-MMU-428890); (R-MMU-525793); (R-MMU-5663213); (R-MMU-5685938); (R-MMU-5693565); (R-MMU-69231); (R-MMU-8939236); (R-MMU-9841922); (R-MMU-9860927)", "pathway_count": 11, "publication_count": 42, "publication_id_list": "10896159;10988075;11114745;11163214;11279004;11279131;11350980;12021275;12107171;12654251;12748290;12775773;14993293;1566087;15686624;17718712;19878872;19895503;19903482;20072125;2065352;2065353;20841568;21690296;21750661;2183353;22810897;25428506;30059200;30084848;30779550;31219806;3283651;3317402;34428180;6319018;7664083;7665185;7780740;8194526;9109492;9636171", "class_list": "glycogene", "function": "Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (By similarity). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. Regulates T-cell differentiation in a TBX21-dependent manner (PubMed:21690296). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (PubMed:22810897). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (PubMed:21690296)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 88, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97896;Q61252;Q61253;Q61254;Q61255;Q61256;Q61257;Q61258;Q61259;Q61260;Q61261;Q6PCM5;Q8C1X4", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.20", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1903055 positive regulation of extracellular matrix organization;GO:0071103 DNA conformation change;GO:0072359 circulatory system development;GO:1903905 positive regulation of establishment of T cell polarity;GO:2000042 negative regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P00520-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923D5-1", "uniprot_id": [ { "id": "WBP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923D5", "type": "external" } ], "mass": 69875.0, "length": 641, "protein_name": "WW domain-binding protein 11", "gene_name": "Wbp11", "organism": "Mouse", "refseq_name": "WW domain-binding protein 11", "refseq_ac": [ { "id": "NP_068360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068360", "type": "external" } ], "gene_names_uniprotkb": "Wbp11; Sipp1", "gene_names_refseq": "2510026P17Rik; D6Wsu113e; Npwbp; SIPP1; Wbp11", "protein_names_uniprotkb": "WW domain-binding protein 11; Splicing factor that interacts with PQBP-1 and PP1; WBP-11", "protein_names_refseq": "Npw38-binding protein; WBP-11; WW domain-binding protein 11; splicing factor that interacts with PQBP-1 and PP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:60321); (R-MMU-72163)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14640981;16162498;17242355;21183079;21540332;21750661;23806337;32923109;33276377;34428180;35820727;9724750", "class_list": "", "function": "Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity., [UniProtKB, PubMed, PubMed]; Identification of SIPP1 as a pre-mRNA splicing factor and a binding partner of protein phosphatase-1., [RefSeq, PubMed]; SIPP1 is a positive regulator of pre-mRNA splicing that is regulated by nucleocytoplasmic shuttling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88539;Q3UMD8;Q8VDI0", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0050699 WW domain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006364 rRNA processing;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q923D5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMB9-1", "uniprot_id": [ { "id": "WASC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMB9", "type": "external" } ], "mass": 136370.0, "length": 1173, "protein_name": "WASH complex subunit 4", "gene_name": "Washc4", "organism": "Mouse", "refseq_name": "WASH complex subunit 4", "refseq_ac": [ { "id": "NP_001028547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547", "type": "external" } ], "gene_names_uniprotkb": "Washc4; Kiaa1033", "gene_names_refseq": "A230046K03Rik; Kiaa1033; Washc4; mKIAA1033", "protein_names_uniprotkb": "WASH complex subunit 4; WASH complex subunit SWIP", "protein_names_refseq": "WASH complex subunit 4; WASH complex subunit 7; WASH complex subunit SWIP", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 43 (Disease Ontology:DOID:0081207); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169)", "pathway": " (mmu:319277)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19922875;21750661;22645316;25428506;30084848;34428180;35820727", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTQ9;Q6ZPZ7;Q8CAK8;Q8CGK0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0071203 WASH complex;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0015031 protein transport;GO:0050890 cognition;GO:0050905 neuromuscular process;GO:0007032 endosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UMB9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64727-1", "uniprot_id": [ { "id": "VINC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64727", "type": "external" } ], "mass": 116717.0, "length": 1066, "protein_name": "Vinculin", "gene_name": "Vcl", "organism": "Mouse", "refseq_name": "vinculin", "refseq_ac": [ { "id": "NP_033528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033528", "type": "external" } ], "gene_names_uniprotkb": "Vcl", "gene_names_refseq": "9430097D22; Vcl", "protein_names_uniprotkb": "Vinculin; Metavinculin", "protein_names_refseq": "metavinculin; vinculin", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 15 (Disease Ontology:DOID:0110321); dilated cardiomyopathy 1W (Disease Ontology:DOID:0110446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:22330); (R-MMU-114608); (R-MMU-445355); (R-MMU-5674135); (R-MMU-6798695); (R-MMU-9764561); (R-MMU-9856530); (R-MMU-9860927); (R-MMU-9958825)", "pathway_count": 9, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10085297;17242355;18630941;19131326;20599708;20610383;21183079;21750661;23386199;25428506;26240176;26359501;26495903;27505886;28316141;30084848;30516436;31219806;33341544;34428180;35820727;36288343;37126682;37507081;37828378;39627609;39927985;7568093;9280281", "class_list": "", "function": "Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP32;Q8BS46;Q922C5;Q922D9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0090636 outer dense plaque of desmosome;GO:0090637 inner dense plaque of desmosome;GO:0061826 podosome ring;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043297 apical junction assembly;GO:0051893 regulation of focal adhesion assembly;GO:1903140 regulation of establishment of endothelial barrier;GO:0007155 cell adhesion;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q64727-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40336-1", "uniprot_id": [ { "id": "VP26A_MOUSE", "url": "https://www.uniprot.org/uniprot/P40336", "type": "external" } ], "mass": 38114.0, "length": 327, "protein_name": "Vacuolar protein sorting-associated protein 26A", "gene_name": "Vps26a", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 26A isoform b", "refseq_ac": [ { "id": "NP_001106826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106826", "type": "external" } ], "gene_names_uniprotkb": "Vps26a; Vps26", "gene_names_refseq": "HB58; Vps26a; Vps26", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 26A; H beta 58; H58 protein; Vesicle protein sorting 26A; mVPS26", "protein_names_refseq": "H beta 58; h58 protein; mVPS26; vacuolar protein sorting 26 homolog A; vacuolar protein sorting-associated protein 26A isoform b; vacuolar protein sorting-associated protein 26A; vacuole protein sorting 26; vesicle protein sorting 26A", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:30930); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "15078902;1638986;18088321;20173027;20875039;21750661;21920005;25136126;25428506;25428507;25605945;26740625;30084848;31219806;34428180;35297035;35820727;37507081;37828378", "class_list": "", "function": "Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (By similarity). Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2 (By similarity). Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (PubMed:25136126)., [UniProtKB, PubMed, UniProtKB, PubMed]; High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGY3;Q3THM5;Q3TW99;Q3UD54;Q8C1E9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40336-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UGF1-1", "uniprot_id": [ { "id": "WDR19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UGF1", "type": "external" } ], "mass": 151457.0, "length": 1341, "protein_name": "WD repeat-containing protein 19", "gene_name": "Wdr19", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 19 isoform a", "refseq_ac": [ { "id": "NP_700440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700440", "type": "external" } ], "gene_names_uniprotkb": "Wdr19; Ift144; Kiaa1638", "gene_names_refseq": "C330027H04Rik; D330023L08Rik; DYF2; Ift144; PWDMP; Wdr19; mKIAA1638", "protein_names_uniprotkb": "WD repeat-containing protein 19; Intraflagellar transport 144 homolog", "protein_names_refseq": "WD repeat membrane protein PWDMP; WD repeat-containing protein 19 isoform a; WD repeat-containing protein 19; intraflagellar transport 144 homolog", "tax_id": 10090, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Caroli disease (Disease Ontology:DOID:0050876); ciliopathy (Disease Ontology:DOID:0060340); spermatogenic failure 72 (Disease Ontology:DOID:0070571); cranioectodermal dysplasia 4 (Disease Ontology:DOID:0080806); asphyxiating thoracic dystrophy 5 (Disease Ontology:DOID:0110089); nephronophthisis 13 (Disease Ontology:DOID:0111121); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:213081); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12906858;16957054;19208653;21750661;22922713;25224227;25860617;34428180;35007346;41018975", "class_list": "", "function": "As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (Probable). Essential for functional IFT-A assembly and ciliary entry of GPCRs (By similarity). Associates with the BBSome complex to mediate ciliary transport (PubMed:22922713)., [UniProtKB, UniProtKB, PubMed, PubMed]; Expressed in normal and neoplastic prostate epithelium and is regulated by androgenic hormones., [RefSeq, PubMed]; Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis, leading to polycystic kidney disease in mice., [RefSeq, PubMed]; Mutations in Ift144, encoding a component of the trafficking machinery of primary cilia assembly, result in a range of embryo patterning defects, affecting the limbs, skeleton and neural system. Here, we show that embryos, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPK8;Q80VQ6;Q8C794;Q8K3R5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0031514 motile cilium;GO:0097730 non-motile cilium;GO:0097228 sperm principal piece", "go_biological_process": "GO:0061055 myotome development;GO:0001701 in utero embryonic development;GO:0050877 nervous system process;GO:0000902 cell morphogenesis;GO:0030326 embryonic limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UGF1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VBE8-1", "uniprot_id": [ { "id": "WDR18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VBE8", "type": "external" } ], "mass": 47211.0, "length": 431, "protein_name": "WD repeat-containing protein 18", "gene_name": "Wdr18", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 18", "refseq_ac": [ { "id": "NP_780659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780659", "type": "external" } ], "gene_names_uniprotkb": "Wdr18", "gene_names_refseq": "2310012I10Rik; Wdr18", "protein_names_uniprotkb": "WD repeat-containing protein 18", "protein_names_refseq": "WD repeat-containing protein 18", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:216156); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22872859;25428506;30084848;31219806;34428180;37828378", "class_list": "", "function": "Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0006364 rRNA processing;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q4VBE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGL7-1", "uniprot_id": [ { "id": "WASC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGL7", "type": "external" } ], "mass": 145311.0, "length": 1334, "protein_name": "WASH complex subunit 2", "gene_name": "Washc2", "organism": "Mouse", "refseq_name": "WASH complex subunit 2", "refseq_ac": [ { "id": "NP_080861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080861", "type": "external" } ], "gene_names_uniprotkb": "Washc2; D6Wsu116e; Fam21; Kiaa0592", "gene_names_refseq": "A130095H06; C530005J20Rik; D6Wsu116e; Fam21; Washc2", "protein_names_uniprotkb": "WASH complex subunit 2", "protein_names_refseq": "WASH complex subunit 2`; WASH complex subunit 2; WASH complex subunit FAM21; family with sequence similarity 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:28006)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17114649;17242355;19131326;19144319;21183079;21750661;25428506;29084197;34428180;36717248;40885482", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L., [UniProtKB, UniProtKB]; FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ99;Q80TW8;Q80UQ4;Q8CAP0", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0036010 protein localization to endosome;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6PGL7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH57-1", "uniprot_id": [ { "id": "WDR48_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH57", "type": "external" } ], "mass": 76007.0, "length": 676, "protein_name": "WD repeat-containing protein 48", "gene_name": "Wdr48", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 48 isoform 1", "refseq_ac": [ { "id": "NP_080512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080512", "type": "external" } ], "gene_names_uniprotkb": "Wdr48; Kiaa1449; Uaf1", "gene_names_refseq": "8430408H12Rik; Uaf1; Wdr48; mKIAA1449", "protein_names_uniprotkb": "WD repeat-containing protein 48; USP1-associated factor 1", "protein_names_refseq": "USP1-associated factor 1; WD repeat-containing protein 48 isoform 1; WD repeat-containing protein 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:67561); (R-MMU-110314); (R-MMU-5689880); (R-MMU-6783310)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "17242355;18034455;21750661;23806337;30084848;31219806;33247121;34428180;36653190;38054892;40021952", "class_list": "", "function": "Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes. Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress., [UniProtKB, UniProtKB]; The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses., [RefSeq, PubMed]; UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression. Publication Status: Online-Only, [RefSeq, PubMed]; USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m[6]A Modification of YAP1 mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80TD4;Q80XI0;Q8BRM0;Q8CBK0;Q922Z9;Q9CRR1;Q9CSL0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003690 double-stranded DNA binding;GO:0043130 ubiquitin binding;GO:0003697 single-stranded DNA binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005770 late endosome;GO:1905368 peptidase complex", "go_biological_process": "GO:1902525 regulation of protein monoubiquitination;GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0035264 multicellular organism growth;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BH57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5H6-1", "uniprot_id": [ { "id": "WASF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5H6", "type": "external" } ], "mass": 61509.0, "length": 559, "protein_name": "Actin-binding protein WASF1", "gene_name": "Wasf1", "organism": "Mouse", "refseq_name": "actin-binding protein WASF1 isoform 1", "refseq_ac": [ { "id": "NP_114083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114083", "type": "external" } ], "gene_names_uniprotkb": "Wasf1; Wave1", "gene_names_refseq": "Scar; WAVE-1; WAVE; Wasf1", "protein_names_uniprotkb": "Actin-binding protein WASF1; Protein WAVE-1; WASP family protein member 1; Wiskott-Aldrich syndrome protein family member 1", "protein_names_refseq": "WAS protein family, member 1; WASP family 1; WASP family protein member 1; actin-binding protein WASF1 isoform 1; actin-binding protein WASF1; protein WAVE-1; wiskott-Aldrich syndrome protein family member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83767); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10970852;12062808;24129315;24153177;26495903;26496209;27605705;29911975;30352064;33300544;35822049", "class_list": "", "function": "Data indicate a molecular protocadherin alpha (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain. Publication Status: Online-Only, [RefSeq, PubMed]; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Also involved in the regulation of mitochondrial dynamics (By similarity)., [UniProtKB, UniProtKB, PubMed]; WAVE-1 restoration improves maze exploration performance of GluN1 knockdown mice Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91W51;Q9ERQ9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0031175 neuron projection development;GO:0030036 actin cytoskeleton organization;GO:0016601 Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R5H6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XU0-1", "uniprot_id": [ { "id": "WRIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XU0", "type": "external" } ], "mass": 71794.0, "length": 660, "protein_name": "ATPase WRNIP1", "gene_name": "Wrnip1", "organism": "Mouse", "refseq_name": "ATPase WRNIP1", "refseq_ac": [ { "id": "NP_084491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084491", "type": "external" } ], "gene_names_uniprotkb": "Wrnip1; Whip", "gene_names_refseq": "4833444L21Rik; WHIP; Wrnip1; Wrnip", "protein_names_uniprotkb": "ATPase WRNIP1; 3.6.1.-; Werner helicase-interacting protein 1", "protein_names_refseq": "ATPase WRNIP1; Werner helicasae interacting protein 1; Werner syndrome homolog interacting protein; werner helicase-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78903)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11301316;16769258;17242355;21183079;21750661;22872234;30084848;31219806;34203471;34428180;36210013", "class_list": "", "function": "Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS., [UniProtKB, UniProtKB]; Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCT7;Q6PDF0;Q8BUW5;Q8BWP6;Q8BY55;Q921W3;Q9EQL3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0045087 innate immune response;GO:0000731 DNA synthesis involved in DNA repair;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91XU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true } ]